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Gynaecological cancers

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https://www.readbyqxmd.com/read/29039136/cancer-risk-management-in-tasmanian-women-with-brca1-and-brca2-mutations
#1
Stephanie Kearton, Karen Wills, Michael Bunting, Penny Blomfield, Paul A James, Jo Burke
Women carrying germline mutations in BRCA1 or BRCA2 have significantly increased lifetime risks of breast and tubo-ovarian cancer. To manage the breast cancer risk women may elect to have breast screening by MRI/mammogram from age 30, to take risk-reducing medication, or to have a prophylactic bilateral mastectomy. To manage the tubo-ovarian cancer risk, the only effective strategy is to have a bilateral salpingo-oophorectomy, recommended by age 40 (BRCA1) or 'around' age 40 (BRCA2). Early studies suggested that uptake of these cancer risk-reducing strategies was low...
October 16, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29031311/nurses-perceptions-of-providing-psychosexual-care-for-women-experiencing-gynaecological-cancer
#2
Natalie F Williams, Yvonne L Hauck, Anna M Bosco
PURPOSE: To gain insight into how Western Australian nurses conceptualise the provision of psychosexual care for women undergoing gynaecological cancer treatment and how this aligns with nurses globally. METHODS: A qualitative descriptive design was chosen to facilitate insight into nurses' perspectives of their reality. Seventeen nurses working at a tertiary women's hospital in Western Australia participated in one-on-one interviews and were asked to describe their perceptions and identify factors that facilitate or challenge psychosexual care provision...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29020396/perception-and-use-of-pap-smear-screening-among-rural-and-urban-women-in-romania
#3
Mihaela Grigore, Razvan Popovici, Anda Pristavu, Ana Maria Grigore, Mioara Matei, Dumitru Gafitanu
Background: In 2012 the National Screening Program for all women between 25 and 64 years of age was launched in Romania. Public awareness is an important factor in the success of a screening program. For this reason, we intended to assess the perception and the level of awareness of Romanian women regarding the Pap test in the prevention of cervical cancer. Methods: A cross-sectional study was conducted among 454 women from rural and urban areas. For our study, we used a questionnaire covering general characteristics, awareness, knowledge and practices regarding cervical cancer and Pap smear...
August 4, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29017913/the-use-of-natural-compounds-for-the-targeting-and-chemoprevention-of-ovarian-cancer
#4
Francesca Pistollato, Ruben Calderón Iglesias, Roberto Ruiz, Silvia Aparicio, Jorge Crespo, Luis Dzul Lopez, Francesca Giampieri, Maurizio Battino
Among gynaecological cancers, ovarian cancer represents the leading cause of death in women. Current treatment for ovarian cancer entails surgery followed by combined chemotherapy with platinum and taxane, which are associated, particularly cisplatin, with severe side effects. While this treatment approach appears to be initially effective in a high number of patients, nearly 70% of them suffer a relapse within a few months after initial treatment. Therefore, more effective and better-tolerated treatment options are clearly needed...
October 7, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29017363/a-survey-on-the-use-of-topical-steroids-in-patients-treated-for-lichen-sclerosus-associated-vulval-squamous-cell-carcinoma
#5
Rachel Pounds, Sanna Tahir, Christopher Dawson, Ciaran Woodman, David Luesley, Jason Yap
Evidence suggests that lichen sclerosus (LS) is the primary aetiological factor for local vulval recurrence (LVR) in vulval squamous cell carcinoma (VSCC). The long-term application of topical corticosteroids is believed to prevent LVR. Patients treated for LS-associated VSCC at a gynaecological cancer centre were invited to complete a questionnaire to evaluate whether they are receiving corticosteroids. 55 of the 95 eligible patients (58%) completed the questionnaire; LS was treated in 69%, with steroids given to 84...
October 10, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28984277/a-multicentre-audit-of-hdr-pdr-brachytherapy-absolute-dosimetry-in-association-with-the-interlace-trial-nct015662405
#6
Patricia Diez, Edwin G A Aird, Thorsten Sander, Clare A Gouldstone, Peter H G Sharpe, Christopher D Lee, Gerry Lowe, Russell A S Thomas, Tania Simnor, Peter Bownes, A Margaret Bidmead, Laura Gandon, David J Eaton, Antony L Palmer
A UK multicentre audit to evaluate HDR and PDR brachytherapy has been performed using alanine absolute dosimetry. This is the first national UK audit performing an absolute dose measurement at a clinically relevant distance (20 mm) from the source. It was performed in both INTERLACE (a phase III multicentre trial in cervical cancer) and non-INTERLACE brachytherapy centres treating gynaecological tumours. Forty-seven UK centres (including the National Physical Laboratory) were visited. A simulated line source was generated within each centre's treatment planning system and dwell times calculated to deliver 10 Gy at 20 mm from the midpoint of the central dwell (representative of Point A of the Manchester system)...
October 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28980114/cancer-survivors-social-context-in-the-return-to-work-process-narrative-accounts-of-social-support-and-social-comparison-information
#7
M Armaou, L Schumacher, E A Grunfeld
Purpose Returning to work is a process that is intertwined with the social aspects of one's life, which can influence the way in which that person manages their return to work and also determines the support available to them. This study aimed to explore cancer patients' perceptions of the role of their social context in relation to returning to work following treatment. Methods Twenty-three patients who had received a diagnosis of either urological, breast, gynaecological, or bowel cancer participated in semi-structured interviews examining general perceptions of cancer, work values and perceptions of the potential impact of their cancer diagnosis and treatment on work...
October 4, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28976616/a-prospective-evaluation-of-the-iota-logistic-regression-models-lr1-and-lr2-in-comparison-to-subjective-pattern-recognition-for-the-diagnosis-of-ovarian-cancer-in-the-outpatient-setting
#8
Natalie Nunes, Gareth Ambler, Xulin Foo, Martin Widschwendter, Davor Jurkovic
OBJECTIVES: To determine whether IOTA diagnostic models developed for pre-operative diagnosis of ovarian cancer could also be used to differentiate between benign and malignant adnexal tumours in the population of women attending gynaecology outpatient clinics. METHODS: All women referred to our outpatient clinic were first examined by a Level II ultrasound operator. In those diagnosed with adnexal tumours the IOTA LR1/2 protocol was used to evaluate the masses...
October 4, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28976125/in-human-alleles-specific-variation-of-mthfr-c677t-and-a1298c-associated-risk-factor-for-the-development-of-ovarian-cancer
#9
Anupama Singh, S Pandey, L K Pandey, Ajit K Saxena
Etiopathology of tumor biology is highly complex and ovarian cancer is one of the important gynaecological neoplasia associated with <b>high risk<b> of mortality rate. Methlenetetrahydrofolate reductase (MTHFR) mutation are commonly linked to folate metabolism with increased risk factor for the development of neural tube defects, recurrent pregnancy loss and development of several type of cancer but genetic interaction between two alleles of MTHFR has been poorly defined in ovarian cancer in India...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28969260/tamoxifen-induced-pancreatitis-an-unusual-complication-of-commonly-used-drug
#10
Pritam Suresh Chandra Kataria, Pradip Piraji Kendre, Apurva Ashok Patel, Murtaza Zoher Bohra, Nahush Tahiliani
Tamoxifen is a selective oestrogen receptor modulator used for the treatment of oestrogen/progesterone receptor positive breast cancer. It possess antagonistic or agonistic activity depending on the tissue location i.e., antagonistic action on breast but agonist action on endometrium and bones. The side effects of tamoxifen include hot flushes, gynaecologic symptoms (vaginal dryness, vaginal discharge), depression, forgetfulness, sleep alterations, weight gain, alteration of lipoprotein metabolism, thromboembolic disorder...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28969237/evaluation-of-iota-simple-ultrasound-rules-to-distinguish-benign-and-malignant-ovarian-tumours
#11
Sugandha Garg, Amarjit Kaur, Jaswinder Kaur Mohi, Preet Kanwal Sibia, Navkiran Kaur
INTRODUCTION: IOTA stands for International Ovarian Tumour Analysis group. Ovarian cancer is one of the common cancers in women and is diagnosed at later stage in majority. The limiting factor for early diagnosis is lack of standardized terms and procedures in gynaecological sonography. Introduction of IOTA rules has provided some consistency in defining morphological features of ovarian masses through a standardized examination technique. AIM: To evaluate the efficacy of IOTA simple ultrasound rules in distinguishing benign and malignant ovarian tumours and establishing their use as a tool in early diagnosis of ovarian malignancy...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28968482/lymphadenectomy-for-the-management-of-endometrial-cancer
#12
REVIEW
Jonathan A Frost, Katie E Webster, Andrew Bryant, Jo Morrison
BACKGROUND: This is an update of a previous Cochrane review published in Issue 1, 2010 and updated in Issue 9, 2015. The role of lymphadenectomy in surgical management of endometrial cancer remains controversial. Lymph node metastases can be found in approximately 10% of women who before surgery are thought to have cancer confined to the womb. Removal of all pelvic and para-aortic lymph nodes (lymphadenectomy) at initial surgery has been widely advocated, and pelvic and para-aortic lymphadenectomy remains part of the FIGO (International Federation of Gynaecology and Obstetrics) staging system for endometrial cancer...
October 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28967199/levels-and-determinants-of-breast-and-cervical-cancer-screening-uptake-in-hiv-infected-women-compared-with-the-general-population-in-france
#13
L Tron, F Lert, B Spire, R Dray-Spira
OBJECTIVES: Cancer is a growing concern for HIV-infected people, and screening plays a major role in alleviating the burden it causes. We sought to investigate the levels and determinants of breast cancer screening (BCS) and cervical cancer screening (CCS) in HIV-infected women as compared with the general population. METHODS: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)-Vespa2 study was conducted in 2011 in a national representative sample of 3022 HIV-infected hospital out-patients in France...
March 2017: HIV Medicine
https://www.readbyqxmd.com/read/28954500/quality-of-life-in-long-term-survivors-of-early-stage-endometrial-cancer
#14
Bożena Dobrzycka, Robert Terlikowski, Bożena Kulesza-Brończyk, Jacek Niklinski, Slawomir Jerzy Terlikowsk
INTRODUCTION: Endometrial cancer (EC) is the most common gynaecological malignancy in developed countries. Effective treatment of the early stage of the disease is achieved by surgery alone. An increasing number of patients with EC become long-term survivors; therefore, the purpose of this study was to investigate the quality-of-life (QOL) of EC survivors. MATERIALS AND METHOD: A total of 328 survivors who had completed cancer treatment more than 3 years ago, and had previously completed questionnaires concerning QOL - European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and depression - Beck Depression Inventory-II (BDI-II)...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28952201/a-phase-ii-randomised-study-to-evaluate-the-efficacy-of-aprepitant-plus-palonosetron-for-preventing-delayed-phase-cinv-associated-with-tc-therapy-in-gynaecological-cancer
#15
Yayoi Sugimori, Tsuyoshi Ota, Takafumi Ujihira, Tomonori Ishiguro, Daiki Ogishima
AIM: Chemotherapy-induced nausea and vomiting (CINV) is one of the most frequently encountered side effects of cancer treatment. Severe CINV can lead patients to refuse chemotherapy, which ultimately affects cancer outcomes. The development of fairly new antiemetic agents, 5-hydroxytryptamine-3 receptor antagonists, palonosetron and neurokinin-1 receptor antagonists and aprepitant has reduced the risk and incidence of CINV. In this study, we assessed the efficacy of aprepitant plus palonosetron against palonosetron for CINV in patients receiving moderately emetic cancer chemotherapy (paclitaxel and carboplatin combination [TC] therapy)...
September 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28952173/impact-of-endometriosis-on-risk-of-further-gynaecological-surgery-and-cancer-a-national-cohort-study
#16
L Saraswat, D Ayansina, K G Cooper, S Bhattacharya, A W Horne, S Bhattacharya
OBJECTIVE: To evaluate the long-term risk of further gynaecological surgery and cancer in women with endometriosis. DESIGN: Cohort study. SETTING: Scotland. PARTICIPANTS: 281 937 women with nearly 5 million person years (4 923 628) of follow up from 1981 to 2010. METHODS: In this national population-based study we compared 17 834 women with a new surgical diagnosis of endometriosis with 83 303 women with no evidence of endometriosis at laparoscopy, 162 966 women who underwent laparoscopic sterilisation, and 17 834 age-matched women from the general population...
September 27, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28951521/isoflurane-promotes-glucose-metabolism-through-upregulation-of-mir-21-and-suppresses-mitochondrial-oxidative-phosphorylation-of-ovarian-cancer-cells
#17
Nai-Liang Guo, Jing-Hua Tan, Jing-Ping Wu, Ying-Hua Xu
Ovarian cancer is one of the most lethal gynecologic malignancies in women. Isoflurane is one of volatile anesthetics used extensively for inhalational anesthesia and gynaecological surgery. However, the effects of isoflurane on ovarian cancer have not been fully elucidated. It is wildly studied that one of the biochemical fingerprints of cancer cells is the altered energy metabolism which is characterized by preferential dependence on glycolysis for energy production in an oxygen-independent manner. In this study, we explored the roles of isoflurane in the regulation of cellular metabolism of ovarian cancer cells...
September 26, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28939343/effects-of-nurse-led-home-based-exercise-cognitive-behavioral-therapy-on-reducing-cancer-related-fatigue-in-patients-with-ovarian-cancer-during-and-after-chemotherapy-a-randomized-controlled-trial
#18
Qi Zhang, Feng Li, Han Zhang, Xiuli Yu, Yunfeng Cong
BACKGROUND: High levels of fatigue have been documented in ovarian cancer patients. However, increased levels of fatigue are positively associated with a high risk of sleep disturbance and depression. OBJECTIVE: To investigate the feasibility of a nurse-led home-based exercise and cognitive behavioral therapy (E&CBT) for ovarian cancer adults with cancer-related fatigue on outcomes of fatigue, plus other secondary outcomes (sleep disturbance and depression), either during or after completion of primary cancer treatment...
August 24, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28936272/hereditary-gynaecologic-cancers-in-nepal-a-proposed-model-of-care-to-serve-high-risk-populations-in-developing-countries
#19
Hanoon P Pokharel, Neville F Hacker, Lesley Andrews
BACKGROUND: Endometrial, ovarian and breast cancers are paradigms for global health disparity. Women living in the developing world continue to present in later stages of disease and have fewer options for treatment than those in developed countries. Risk reducing surgery is of proven benefit for women at high risk of gynaecological cancer. There is no specific model for identification and management of such women in the developing world. METHODS: We have integrated data from our published audit of a major gynaecological oncology centre at Royal Hospital for Women in Australia, with data from our survey and a focus group discussion of Nepalese gynaecological health care professionals regarding genetic testing, and findings from the literature...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28933580/the-role-of-cediranib-in-ovarian-cancer
#20
Cecilia Orbegoso, Gloria Marquina, Angela George, Susana Banerjee
Treatment options for relapsed ovarian cancer have increased over the decade with the addition of targeted agents, such as PARP inhibitors and antiangiogenic agents. Bevacizumab, a monoclonal antibody binding vascular endothelial growth factor (VEGF), was the first anti-angiogenic agent to be incorporated in the ovarian cancer treatment landscape. Other molecules utilising different mechanisms of action to target angiogenesis have been developed, including cediranib, an oral potent inhibitor of VEGF Tyrosine Kinase Inhibitor that has demonstrated activity in both phase II and phase III studies...
October 2017: Expert Opinion on Pharmacotherapy
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