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Gynaecological cancers

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https://www.readbyqxmd.com/read/29691126/outcome-and-prognostic-impact-of-surgical-staging-in-serous-tubal-intraepithelial-carcinoma-a-cohort-study-and-systematic-review
#1
N M A Van der Hoeven, K Van Wijk, S E Bonfrer, J J Beltman, L A Louwe, C D De Kroon, C J Van Asperen, K N Gaarenstroom
The optimal management of breast cancer susceptibility gene (BRCA)1/2 carriers with isolated serous tubal intraepithelial carcinoma (STIC) found at risk-reducing salpingo-oophorectomy (RRSO) is unclear. The prevalence of occult carcinoma and STIC in a consecutive series of BRCA1/2 carriers undergoing RRSO is reported. The outcome of staging procedures in BRCA1/2 carriers with isolated STIC at RRSO as well as the relationship between staging, chemotherapy treatment and risk of recurrence was assessed via a systematic review of the literature...
April 21, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29688967/the-european-society-of-gynaecological-oncology-european-society-for-radiotherapy-and-oncology-european-society-of-pathology-guidelines-for-the-management-of-patients-with-cervical-cancer
#2
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
BACKGROUND: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer. OBJECTIVE: The European Society of Gynaecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide...
May 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29684351/stat3-activation-by-il-6-from-adipose-derived-stem-cells-promotes-endometrial-carcinoma-proliferation-and-metastasis
#3
Yijing Chu, Yan Wang, Wei Peng, Lin Xu, Meixin Liu, Jing Li, Xiaoyu Hu, Yan Li, Jianxin Zuo, Yuanhua Ye
Endometrial cancer is the most common gynaecological cancer, and its incidence is increasing. Obesity is a well-recognized risk factor for endometrial cancer, and the mechanisms by which adipose tissue influences tumour development remain controversial. In this study, we examined the high IL-6 level in the ADSCs supernatant following treatment of endometrial cancer cell CM. Then, the activation of STAT3, a major tumourigenic IL-6 effector, was examined in endometrial cancer cells. Conditioned ADSC medium was used to stimulate endometrial cancer cell growth in vitro...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29683929/18f-fdg-pet-ct-in-the-evaluation-of-cancer-cervix-where-do-we-stand-today
#4
Shanmuga S Palaniswamy, Chaitanya R Borde, Padma Subramanyam
The incidence of gynecological malignancies is on the rise partly because of the availability of screening programmes, awareness, higher technological advancements, and availability of better medical care. Early diagnosis of any malignancy leads to prompt treatment. Use of 18Fluorine-Fluorodeoxyglucose (F-FDG) PET/CT in the treatment and follow-up of patients with Ca cervix considerably improves patient management. The primary diagnosis of Ca cervix is made either by biopsy of a visible tumor on the cervix or by a cone biopsy of a nonvisible malignant cervical focus...
April 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29682207/racial-differences-in-endometrial-cancer-molecular-portraits-in-the-cancer-genome-atlas
#5
David S Guttery, Kevin Blighe, Konstantinos Polymeros, R Paul Symonds, Salvador Macip, Esther L Moss
Endometrial cancer (EC) is now the most prevalent gynaecological malignancy in the Western world. Black or African American women (BoAA) have double the mortality of Caucasian women, and their tumours tend to be of higher grade. Despite these disparities, little is known regarding the mutational landscape of EC between races. Hence, we wished to investigate the molecular features of ECs within The Cancer Genome Atlas (TCGA) dataset by racial groupings. In total 374 Caucasian, 109 BoAA and 20 Asian patients were included in the analysis...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681775/does-itv-vaginal-procedure-ensure-dosimetric-coverage-during-imrt-of-post-operative-gynaecological-tumours-without-instructions-concerning-rectal-filling
#6
Ramona Verges, Alexandra Giraldo, Alejandro Seoane, Elisabet Toral, M Carmen Ruiz, Ariadna Pons, Jordi Giralt
Aim: To find out whether the internal target volume (ITV) vaginal procedure ensures dosimetric coverage during intensity-modulated radiation therapy (IMRT) of post-operative gynaecological tumours without instructions on rectal filling. Background: The ITV vaginal procedure does not necessarily include all movements of the bladder, and does not include changes in the rectal volume. We should know if the vaginal ITV is a useful tool in maintaining CTV coverage during treatment...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29673836/effects-of-lifestyle-modification-on-cancer-recurrence-overall-survival-and-quality-of-life-in-gynaecological-cancer-survivors-a-systematic-review-and-meta-analysis
#7
REVIEW
Ladan Yeganeh, Cheryce Harrison, Amanda J Vincent, Helena Teede, Jacqueline A Boyle
The benefits of lifestyle interventions for women who have survived gynaecological cancer (GC) remain unclear. This systematic review aimed to determine the effect of lifestyle interventions on cancer recurrence, overall survival and quality of life (QoL) in women with GC. We searched Medline, Embase, PsycINFO and EBM Reviews from June to July 2016 to identify relevant literature. We included randomized controlled trials in which a lifestyle intervention (diet, weight loss, physical activity and/or behavioural interventions) were compared with a control condition (usual care, placebo or other lifestyle interventions) in women who had survived endometrial or ovarian cancer...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29670294/the-surgical-intelligent-knife-distinguishes-normal-borderline-and-malignant-gynaecological-tissues-using-rapid-evaporative-ionisation-mass-spectrometry-reims
#8
David L Phelps, Júlia Balog, Louise F Gildea, Zsolt Bodai, Adele Savage, Mona A El-Bahrawy, Abigail Vm Speller, Francesca Rosini, Hiromi Kudo, James S McKenzie, Robert Brown, Zoltán Takáts, Sadaf Ghaem-Maghami
BACKGROUND: Survival from ovarian cancer (OC) is improved with surgery, but surgery can be complex and tumour identification, especially for borderline ovarian tumours (BOT), is challenging. The Rapid Evaporative Ionisation Mass Spectrometric (REIMS) technique reports tissue histology in real-time by analysing aerosolised tissue during electrosurgical dissection. METHODS: Aerosol produced during diathermy of tissues was sampled with the REIMS interface. Histological diagnosis and mass spectra featuring complex lipid species populated a reference database on which principal component, linear discriminant and leave-one-patient-out cross-validation analyses were performed...
April 19, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29663291/apatinib-a-review-in-advanced-gastric-cancer-and-other-advanced-cancers
#9
Lesley J Scott
Apatinib [AiTan™ (China); Rivoceranib® (global)] is a novel, small molecule, selective vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor and is the second anti-angiogenic drug to be approved in China for the treatment of advanced or metastatic gastric cancer. This article summarizes the pharmacological properties of apatinib and reviews its clinical use in chemotherapy-experienced patients with advanced gastric adenocarcinoma, including gastroesophageal adenocarcinoma (GEA), or with other advanced cancers such as non-small cell lung cancer (NSCLC), breast cancer, gynaecological cancers, hepatocellular carcinoma (HCC), thyroid cancer and sarcomas...
April 16, 2018: Drugs
https://www.readbyqxmd.com/read/29662533/highlights-from-the-10th-breast-gynaecological-and-immunotherapy-international-cancer-conference-bgicc-18-19-january-2018-cairo-egypt
#10
Hesham El-Ghazaly, Adel Aref, Nermeen Bahie-Eldin
During the 10th Breast, Gynaecological and Immunotherapy International Cancer Conference (BGICC), which was held on 18 and 19 of January, 2018, in Cairo, Egypt, around 100 international, regional and national experts presented the latest updates in breast cancer, gynaecological cancers and immunotherapy in oncology. Through this report, we will try to highlight the important data and consensus issues that were discussed during the conference.
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29660578/implementing-the-risk-of-endometrial-malignancy-algorithm-rem-adding-obesity-as-a-predictive-factor-results-of-rem-b-in-a-single-center-survey
#11
Francesco Plotti, Stella Capriglione, Giuseppe Scaletta, Daniela Luvero, Salvatore Lopez, Francesca Fiori Nastro, Corrado Terranova, Carlo De Cicco Nardone, Roberto Montera, Roberto Angioli
OBJECTIVE: In 2013, our group assessed a risk stratification tool of endometrial cancer (EC), called REM (Risk of Endometrial Malignancy). A well known risk factor for EC is body mass index (BMI). In fact, (BMI > 30 and <35 kg/m2) and severe obesity (BMI > 35 kg/m2) were associated with a 2.6-fold and a 4.7-fold increase in EC risk, respectively. Therefore, in the present study we aim to improve the performance of REM, including BMI and developing a new scoring system, called REM-B (Risk of Endometrial Malignancy score associated to BMI), to classify patients into high risk or low risk groups for EC...
April 7, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29659191/optimised-arid1a-immunohistochemistry-is-an-accurate-predictor-of-arid1a-mutational-status-in-gynaecological-cancers
#12
Saira Khalique, Kalnisha Naidoo, Ayoma D Attygalle, Divya Kriplani, Frances Daley, Anne Lowe, James Campbell, Thomas Jones, Michael Hubank, Kerry Fenwick, Nicholas Matthews, Alistair G Rust, Christopher J Lord, Susana Banerjee, Rachael Natrajan
ARID1A is a tumour suppressor gene that is frequently mutated in clear cell and endometrioid carcinomas of the ovary and endometrium and is an important clinical biomarker for novel treatment approaches for patients with ARID1A defects. However, the accuracy of ARID1A immunohistochemistry (IHC) as a surrogate for mutation status has not fully been established for patient stratification in clinical trials. Here we tested whether ARID1A immunohistochemistry could reliably predict ARID1A mutations identified by next-generation sequencing...
April 16, 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29651778/cost-consequence-analysis-alongside-a-randomised-controlled-trial-of-hospital-versus-telephone-follow-up-after-treatment-for-endometrial-cancer
#13
Padraig Dixon, Kinta Beaver, Susan Williamson, Chris Sutton, Pierre Martin-Hirsch, William Hollingworth
BACKGROUND: Regular outpatient follow-up programmes are usually offered to patients following treatment for gynaecological and other cancers. Despite the substantial resources involved in providing these programmes, there is evidence that routine follow-up programmes do not affect survival or the likelihood of detecting recurrence and may not meet patient needs. Alternative follow-up modalities may offer the same outcomes at lower cost. We examined the costs of using telephone-based routine follow-up of women treated for endometrial cancer undertaken by specialist gynaecology oncology nurses in comparison to routine hospital-based follow-up...
April 12, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29648645/does-human-endometrial-lgr5-gene-expression-suggest-the-existence-of-another-hormonally-regulated-epithelial-stem-cell-niche
#14
N Tempest, A M Baker, N A Wright, D K Hapangama
STUDY QUESTION: Is human endometrial leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) gene expression limited to the postulated epithelial stem cell niche, stratum basalis glands, and is it hormonally regulated? SUMMARY ANSWER: LGR5 expressing cells are not limited to the postulated stem cell niche but LGR5 expression is hormonally regulated. WHAT IS KNOWN ALREADY: The human endometrium is a highly regenerative tissue; however, endometrial epithelial stem cell markers are yet to be confirmed...
April 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29621923/laparoscopic-hysterectomy-for-endometrial-cancer-impact-of-age-on-clinical-outcomes
#15
W W Ee, V Nellore, W McMullen, K Ragupathy
INTRODUCTION: Improvement in preoperative care for the ageing population has resulted in an increasing number of elderly patients to be considered for surgery. With an increased incidence of endometrial cancer, it is inevitable that a significant number of elderly patients are referred for surgery, despite the concerns over co-morbid conditions and diminished cardiopulmonary reserves. AIM: To evaluate the clinical outcomes of laparoscopic hysterectomy for elderly women operated on for endometrial cancer with comparison to younger patients...
April 6, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29595758/surgical-treatment-of-early-stage-cervical-cancer-a-multi-institution-experience-in-2124-cases-in-the-netherlands-over-a-30-year-period
#16
Marloes Derks, Jacobus van der Velden, Cornelis D de Kroon, Hans W Nijman, Luc R C W van Lonkhuijzen, Ate G J van der Zee, Aeilko H Zwinderman, Gemma G Kenter
OBJECTIVE: This study aimed to describe the pattern of recurrence and survival related to prognostic variables, including type of surgery as a clinical variable, in patients surgically treated for early cervix cancer. METHODS: Records of 2124 patients who underwent a radical hysterectomy for International Federation of Gynaecology and Obstetrics stage I/IIA cervical cancer between 1982 and 2011 were reviewed. Clinical-pathologic prognostic variables, also including extent of parametrectomy, were identified and used in a multivariable Cox proportional hazard model to explore associations between disease-free survival (DFS) and prognostic variables...
March 27, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29588102/women-treated-for-gynaecological-cancer-during-young-adulthood-a-mixed-methods-study-of-perceived-psychological-distress-and-experiences-of-support-from-health-care-following-end-of-treatment
#17
Elisabet Mattsson, Kim Einhorn, Lisa Ljungman, Inger Sundström-Poromaa, Karin Stålberg, Anna Wikman
OBJECTIVE: To investigate the prevalence and predictors of cancer-related distress in younger women treated for gynaecological cancer, and to explore women's needs and experiences of psychosocial support following end-of-treatment. METHODS: Data were collected from 337 gynaecological cancer survivors, 19-39years at diagnosis, using a study-specific questionnaire and the Swedish Quality Register of Gynaecologic Cancer. Predictors of distress were investigated with multivariable logistic regression analysis...
March 24, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29575880/modifiable-lifestyle-factors-and-ovarian-cancer-incidence-in-women
#18
Katarzyna Plagens-Rotman, Karolina Chmaj-Wierzchowska, Beata Pięta, Iwona Bojar
INTRODUCTION: A correct diet plays an important role in the prevention of malignant tumours. The risk of the disease may be reduced by introducing a number of changes to the daily diet. The most important changes concern the amount of fat in the diet, dietary fibre, antioxidants in the food and the reduction of substances having a significant impact on the development of malignant tumours. OBJECTIVE: The aim of the study is to analyse the role of selected modifiable lifestyle factors affecting the development of ovarian cancer...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29569937/the-role-of-micrornas-and-nanoparticles-in-ovarian-cancer-a-review
#19
Leila Kafshdooz, Hojjat Pourfathi, Abolfazl Akbarzadeh, Taiebeh Kafshdooz, Zohre Razban, Roghayeh Sheervalilou, Naser Ebrahimi Sadr, Rovshan Khalilov, Siamak Saghfi, Taras Kavetskyy, Lala Mammadova, Masoud Mehrizadeh, Samaneh Ghasemali
MicroRNAs (miRNAs) have had a revolutionary impact on cancer research over the recent years. They emerge as important players in tumourigenesis, leading to a paradigm shift in oncology. Ovarian cancer is the leading cause of death among gynaecologic malignancies. Therefore, there is a strong need for prognostic and predictive markers for early diagnosis which helps optimize and personalize treatment. Asymptomatically, ovarian cancer is often diagnosed at advanced and incurable stages. Efficient targeting and sustained release of miRNAs/anti-miRNAs using nanoparticles conjugated with antibodies and/or peptides could reduce the required therapeutic dosage while minimizing systemic and cellular toxicity...
March 23, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29565053/-quality-of-life-and-chemotherapy-predictive-factors-in-a-sample-of-gynaecological-cancer-patients
#20
Valentina Elisabetta Di Mattei, Letizia Carnelli, Paola Taranto, Martina Mazzetti, Paola Maria Vittoria Rancoita, Alice Bergamini, Micaela Petrone, Emanuela Rabaiotti, Lucio Sarno, Massimo Candiani
INTRODUCTION: Diagnosis and treatment of gynaecological cancer still entail significant impairment in quality of life. The present study aims at monitoring it during chemotherapy treatment and at identifying variables significantly associated with it. METHODS: 87 patients who attended the San Raffaele Hospital completed the EORTC QLQ-C30 and the Multidimensional Scale of Perceived Social Support before their first and third chemotherapy infusion. A self-report questionnaire was created in order to collect socio-demographic and medical information...
March 2018: Recenti Progressi in Medicina
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