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head neck cancer surgery

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https://www.readbyqxmd.com/read/28812214/the-role-of-human-papillomavirus-on-the-prognosis-and-treatment-of-oropharyngeal-carcinoma
#1
Nicholas Fung, Farhoud Faraji, Hyunseok Kang, Carole Fakhry
Human papillomavirus positive oropharyngeal cancer (HPV-positive OPC) is a distinct subtype of head and neck carcinoma (HNC) distinguished from HPV-negative HNC by its risk factor profile, clinical behavior, and molecular biology. Compared to HPV-negative HNC, HPV-positive OPC exhibits significantly better prognosis and an enhanced response to treatment. Recognition of the survival benefit of HPV-positive tumors has led to therapeutic de-intensification strategies aiming to mitigate treatment-related toxicities while maintaining high response rates...
August 15, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28807072/clavicle-fracture-with-osteomyelitis-after-neck-dissection-and-post-operative-radiotherapy-case-report
#2
R Shodo, Y Sato, H Ota, A Horii
BACKGROUND: Non-traumatic bone fractures in cancer patients are usually pathological fractures due to bone metastases. In head and neck cancer patients, clavicle stress fractures may occur as a result of atrophy of the trapezius muscle after neck dissection in which the accessory nerve becomes structurally or functionally damaged. CASE REPORT: A 71-year-old man underwent modified radical neck dissection with accessory nerve preservation and post-operative radiotherapy for submandibular lymph node metastases of tongue cancer...
August 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28802390/pediatric-head-and-neck-bone-sarcomas-an-analysis-of-204-cases
#3
Jacob S Brady, Sei Y Chung, Emily Marchiano, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park
OBJECTIVES: To analyze the demographics, survival, and treatment efficacy of pediatric sarcomas of the facial skeleton and skull. METHODS: Retrospective study of cases from the US National Cancer Institute's Surveillance, Epidemiology, and End Results database. Pediatric patients between the ages of 0 and 18 diagnosed with a malignant sarcoma of either the mandible or the bones of skull, face, and associated joints from 1973 to 2013 were studied. RESULTS: In total, 204 patients were included in the analysis...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28797451/post-operative-therapy-following-transoral-robotic-surgery-for-unknown-primary-cancers-of-the-head-and-neck
#4
Sapna A Patel, Aarthi Parvathaneni, Upendra Parvathaneni, Jeffrey J Houlton, Ron J Karni, Jay J Liao, Neal D Futran, Eduardo Méndez
OBJECTIVES: Our primary objective is to describe the post- operative management in patients with an unknown primary squamous cell carcinoma of the head and neck (HNSCC) treated with trans-oral robotic surgery (TORS). MATERIALS & METHODS: We conducted a retrospective multi-institutional case series including all patients diagnosed with an unknown primary HNSCC who underwent TORS to identify the primary site from January 1, 2010 to June 30, 2016. We excluded those with recurrent disease, ≤6months of follow up from TORS, previous history of radiation therapy (RT) to the head and neck, or evidence of primary tumor site based on previous biopsies...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28796101/use-of-the-ipsilateral-anteromedial-thigh-flap-for-immediate-rescue-of-nonviable-anterolateral-thigh-flaps-in-head-and-neck-cancer-reconstruction
#5
Hsu-Tang Cheng, Jin-Yi Tian, Yung-Chang Hsu, Hsin-Han Chen, Sophia Chia-Ning Chang
BACKGROUND: It is not always possible to use the anatomically variable free anterolateral thigh (ALT) flap for reconstructive surgery. An anteromedial thigh (AMT) flap serves as a good alternative, and shares the same vascular pedicle as the ALT flap. METHODS: Of 698 reconstructions performed in 2006 to 2013 following head and neck tumor ablation surgery, ALT flaps were used in 653 patients. Eighteen free AMT flaps were harvested to replace variant nonviable ALT flaps...
August 8, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28794691/biological-role-of-long-non-coding-rna-in-head-and-neck-cancers
#6
REVIEW
Tomasz Kolenda, Kacper Guglas, Marcel Ryś, Marta Bogaczyńska, Anna Teresiak, Renata Bliźniak, Izabela Łasińska, Jacek Mackiewicz, Katarzyna M Lamperska
Head and neck squamous cell carcinoma (HNSCC) are one of the worst prognosis cancers with high mortality of patients. The treatment strategy is primarily based on surgery and radiotherapy but chemotherapy is also used. Every year the knowledge concerning HNSCC biology is updated with new elements such as the recent discovered molecules - long non-coding RNAs. Long non-coding RNAs are involved in regulatory processes in the cells. It has been revealed that the expression levels of lncRNAs are disturbed in tumor cells what results in the acquisition of their specific phenotype...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28792850/literature-review-of-criteria-for-defining-recipient-site-infection-after-oral-oncologic-surgery-with-simultaneous-reconstruction
#7
Masaya Akashi, Junya Kusumoto, Akiko Sakakibara, Kazunobu Hashikawa, Shungo Furudoi, Takahide Komori
BACKGROUND: The lack of uniformity of criteria for defining recipient-site infection after oral oncologic surgery with simultaneous reconstruction is problematic despite numerous studies on this issue. This study aimed to investigate the difference in the criteria for defining recipient-site infection after oral oncologic surgery with reconstruction. METHODS: A Medline search was performed via PUBMED using the following combinations of key terms that were tagged in the title, abstract, or both: "surgical site infection-head neck," "surgical site infection-oral cancer," "antibiotic prophylaxis-head neck," and "surgical site infection-oral carcinoma...
August 9, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28791405/silibinin-suppresses-bladder-cancer-cell-malignancy-and-chemoresistance-in-an-nf-%C3%AE%C2%BAb-signal-dependent-and-signal-independent-manner
#8
Yi Sun, Zhenfeng Guan, Wencai Zhao, Yazhuo Jiang, Qing Li, Yongyi Cheng, Yonggang Xu
Because bladder cancer (BCa) is the 9th most common malignant tumor and 13th leading cause of death due to cancer, therapeutic approaches have attracted a great deal of attention from both clinicians and BCa patients. Although the development of surgery and targeted drugs has brought new challenges for the traditional concept of BCa therapy, various types of chemotherapy remain the final treatment method for many BCa patients. However, chemoresistance inevitably appears, leading to the failure of chemotherapy...
August 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28771728/quality-of-life-outcomes-of-transoral-robotic-surgery-with-or-without-adjuvant-therapy-for-oropharyngeal-cancer
#9
Rishabh Sethia, Ali C Yumusakhuylu, Isa Ozbay, Virginia Diavolitsis, Nicole V Brown, Songzhu Zhao, Lai Wei, Matthew Old, Amit Agrawal, Theodoros N Teknos, Enver Ozer
OBJECTIVES/HYPOTHESIS: To compare quality of life (QOL) of patients who underwent transoral robotic surgery (TORS) alone, with adjuvant radiation therapy (RT), or adjuvant chemoradiation therapy (CRT) in the treatment of oropharyngeal squamous cell cancer (OPSCCA). STUDY DESIGN: Prospective cohort study. METHODS: Medical records were reviewed for 111 patients treated for OPSCCA from 2008 to 2015. Patients were administered the Head and Neck Cancer Inventory (HNCI) to evaluate QOL preoperatively, and at 3 weeks, 3 months, 6 months, and 1 year postsurgery...
August 3, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28770621/longitudinal-perioperative-pain-assessment-in-head-and-neck-cancer-surgery
#10
Marisa R Buchakjian, Andrew B Davis, Sebastian J Sciegienka, Nitin A Pagedar, Steven M Sperry
OBJECTIVE: To evaluate perioperative pain in patients undergoing major head and neck cancer surgery and identify associations between preoperative and postoperative pain characteristics. METHODS: Patients undergoing head and neck surgery with regional/free tissue transfer were enrolled. Preoperative pain and validated screens for symptoms (neuropathic pain, anxiety, depression, fibromyalgia) were assessed. Postoperatively, patients completed a pain diary for 4 weeks...
September 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28766791/symptom-burden-and-patient-characteristics-association-with-quality-of-life-in-patients-with-head-and-neck-cancer-undergoing-radiotherapy
#11
Guro Lindviksmoen Astrup, Tone Rustøen, Kristin Hofsø, Jon Michael Gran, Kristin Bjordal
BACKGROUND: Patients with head and neck cancer (HNC) experience diminished quality of life (QOL) during and after treatment. This study examined which characteristics were associated with QOL over time. METHODS: One hundred thirty-three patients with HNC from a study of 534 oncology patients rated physical and mental QOL using the Short Form-12 5 times from the initiation of radiotherapy (RT) through the following 6 months. Linear mixed model analyses examined changes over time and associated characteristics...
August 2, 2017: Head & Neck
https://www.readbyqxmd.com/read/28766109/treatment-of-medication-related-osteonecrosis-of-the-jaw-and-its-impact-on-a-patient-s-quality-of-life-a-single-center-10-year-experience-from-southern-italy
#12
Giacomo Oteri, Gianluca Trifirò, Matteo Peditto, Loredana Lo Presti, Ilaria Marcianò, Francesco Giorgianni, Janet Sultana, Antonia Marcianò
INTRODUCTION: No official guidelines are available for the management of medication-related osteonecrosis of the jaw (MR-ONJ). The additional benefit of surgery after pharmacological treatment is debated by both clinicians and patients. OBJECTIVE: The aim of this study was to evaluate the changes in patients' MR-ONJ-related quality of life (QoL) after pharmacological treatment with or without surgery in a large cohort affected by MR-ONJ. METHODS: Anonymized data on patients diagnosed with MR-ONJ were extracted from the database of the Osteonecrosis of the Jaw Treatment Center (University of Messina, Italy) in the years 2005-2015...
August 1, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28755704/it-takes-two-one-resects-one-reconstructs
#13
REVIEW
Shabnam Ghazizadeh, Edward C Kuan, Jon Mallen-St Clair, Elliot Abemayor, Quang Luu, Vishad Nabili, Maie A St John
Care of patients with advanced head and neck cancer is a multidisciplinary effort through all phases of care. Head and neck cancer surgery involves balancing oncologic control, functional preservation, and aesthetics. Given the advances in free tissue reconstruction, the majority of defects can be reconstructed using free tissue transfer flaps. A 2-team approach allows for early, continual communication and meticulous operative planning. Operations can be combined into a single effort. This approach maximizes efficiency and enables multidisciplinary collaboration for comprehensive surgical treatment...
August 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28755160/successful-video-assisted-thoracoscopic-surgery-in-prone-position-in-patients-with-esophageal-cancer-and-aberrant-right-subclavian-artery-report-of-three-cases
#14
Koji Shindo, Eishi Nagai, Toshinaga Nabae, Toru Eguchi, Taiki Moriyama, Kenoki Ohuchida, Tatsuya Manabe, Takao Ohtsuka, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura
BACKGROUND: An aberrant right subclavian artery (ARSA) with an associated nonrecurrent right inferior laryngeal nerve (NRILN) is a relatively rare anomaly that occurs at a frequency of 0.3 to 2.0% of the general population. NRILN has been mainly documented in the head and neck region; it has been rarely described in patients with esophageal cancer, especially those undergoing thoracoscopic surgery. Video-assisted thoracoscopic surgery for esophageal cancer (VATS-E) is becoming more widespread as a reliable minimally invasive surgical procedure associated with reduced perioperative complications...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28740894/postoperative-radiation-therapy-is-associated-with-a-reduced-risk-of-local-recurrence-among-low-risk-merkel-cell-carcinomas-of-the-head-and-neck
#15
Seesha R Takagishi, Tessa E Marx, Christopher Lewis, Erica S Tarabadkar, Ilsa D Juhlin, Astrid Blom, Jayasri G Iyer, Jay J Liao, Yolanda D Tseng, Teresa Fu, Paul Nghiem, Upendra Parvathaneni
PURPOSE: Merkel cell carcinoma (MCC) is a rare and often aggressive skin cancer. Typically, surgery is the primary treatment. Postoperative radiation therapy (PORT) is often recommended to improve local control. It is unclear whether PORT is indicated in patients with favorable Stage IA head and neck (HN) MCC. METHODS AND MATERIALS: We conducted a retrospective analysis of 46 low-risk HN MCC cases treated between 2006 and 2015. Inclusion criteria were defined as a primary tumor size of ≤ 2 cm, negative pathological margins, negative sentinel lymph node biopsy, and no immunosuppression...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740764/multiple-free-flap-reconstructions-of-head-and-neck-defects-due-to-oral-cancer
#16
Yumi Mochizuki, Hiroyuki Harada, Hiroaki Shimamoto, Hirofumi Tomioka, Hideaki Hirai
OBJECTIVE: We studied complications following multiple free flap reconstructions in the head and neck. METHODS: In this cohort, 26 patients (14 men and 12 women) who underwent multiple microvascular free flap reconstructions were included in the study. The reasons for secondary reconstruction were recurrence of tumor (12 cases), necrosis of transferred skin and/or bone (6 cases), reconstruction plate fracture or exposure (4 cases), and others (4 cases). A third reconstruction in 4 cases and a fourth reconstruction in 1 case were performed...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28738193/degree-of-keratinization-is-an-independent-prognostic-factor-in-oral-squamous-cell-carcinoma
#17
Susanne Wolfer, Stefan Elstner, Stefan Schultze-Mosgau
PURPOSE: Keratinization is a routinely reported histologic feature in head and neck cancer. In contrast to numerous clinicopathologic parameters, the prognostic value of keratinization in oral squamous cell carcinoma (OSCC) is rarely reported in the literature. The purpose of this study was to review the outcome of patients with OSCC with a special focus on the degree of keratinization. PATIENTS AND METHODS: In this retrospective cohort study, we evaluated the medical records at the Department of Oral and Maxillofacial Surgery, Jena University Hospital, and investigated the outcome of patients with OSCC with disease-free survival and disease-specific survival according to the degree of keratinization...
June 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28737019/clinical-outcomes-for-patients-presenting-with-n3-head-and-neck-squamous-cell-carcinoma-analysis-of-the-national-cancer-database
#18
Huaising C Ko, Shuai Chen, Aaron M Wieland, Menggang Yu, Andrew M Baschnagel, Gregory K Hartig, Paul M Harari, Matthew E Witek
BACKGROUND: There is a paucity of data regarding head and neck squamous cell carcinomas (HNSCCs) and N3 nodal disease. METHODS: Retrospective analysis of patients with N3 HNSCC identified in the National Cancer Database (NCDB) was performed. RESULTS: We identified 4867 patients with N3 HNSCC treated with primary surgery or chemoradiotherapy (CRT). Propensity-adjusted median survival was 54.2 and 44.8 months for surgery and CRT, respectively (P = ...
July 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28736725/intraoperative-radiation-therapy-a-promising-treatment-modality-in-head-and-neck-cancer
#19
REVIEW
Lara Hilal, Karine A Al Feghali, Paul Ramia, Ibrahim Abu Gheida, Jean-Pierre Obeid, Wassim Jalbout, Bassem Youssef, Fady Geara, Youssef H Zeidan
Every year, almost 62,000 are diagnosed with a head and neck cancer (HNC) and 13,000 will succumb to their disease. In the primary setting, intraoperative radiation therapy (IORT) can be used as a boost in select patients in order to optimize local control. Addition of external beam radiation to limited volumes results in improved disease control over surgery and IORT alone. In the recurrent setting, IORT can improve outcomes from salvage surgery especially in patients previously treated with external beam radiation...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28731497/the-effect-of-frailty-on-short-term-outcomes-after-head-and-neck-cancer-surgery
#20
Carrie L Nieman, Karen T Pitman, Anthony P Tufaro, David W Eisele, Kevin D Frick, Christine G Gourin
OBJECTIVE: To determine the relationship between frailty and comorbidity, in-hospital mortality, postoperative complications, length of hospital stay (LOS), and costs in head and neck cancer (HNCA) surgery. STUDY DESIGN: Cross-sectional analysis. METHODS: Discharge data from the Nationwide Inpatient Sample for 159,301 patients who underwent ablative surgery for a malignant oral cavity, laryngeal, hypopharyngeal, or oropharyngeal neoplasm in 2001 to 2010 was analyzed using cross-tabulations and multivariate regression modeling...
July 21, 2017: Laryngoscope
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