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Vinícius Menezes Tunholi-Alves, Victor Menezes Tunholi, Juberlan Garcia, Esther Maria Mota, Rosane Nora Castro, Emerson Guedes Pontes, Jairo Pinheiro
For the first time, alterations in the oxidative metabolism of Achatina fulica experimentally infected with different parasite loads of Angiostrongylus cantonensis were determined. For this, the hemolymph activities of lactate dehydrogenase (LDH) and hexokinase and the glucose concentrations in the hemolymph, as well as the polysaccharide reserves in the digestive gland and cephalopedal mass, were assessed. Additionally, the contents of some carboxylic acids in the hemolymph of infected and uninfected snails were determined by high-performance liquid chromatography (HPLC), permitting a better understanding of the alterations related to the host's oxidative metabolism...
April 21, 2018: Parasitology Research
Fernando de Castro Jacinavicius, Ricardo Bassini-Silva, Jairo Alfonso Mendoza-Roldan, Almir Rogério Pepato, Ronald Ochoa, Cal Welbourn, Darci Moraes Barros-Battesti
A checklist of the family Trombiculidae and Leeuwenhoekiidae is presented, containing 63 species in 30 genera of chiggers from 80 different hosts and 146 localities in Brazil. The type locality and depository are provided, including new locality and host records for the country.
2018: ZooKeys
Andrés Jenuer Matta, Diana Carolina Zambrano, Alvaro Jairo Pazos
AIM: To characterize punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori ( H. pylori ) and determine their association with therapeutic failure. METHODS: PCR products of 23S rRNA gene V domain of 74 H. pylori isolates; 34 resistant to clarithromycin (29 from a low-risk gastric cancer (GC) population: Tumaco-Colombia, and 5 from a high-risk population: Tuquerres-Colombia) and 40 from a susceptible population (28 from Tumaco and 12 from Túquerres) were sequenced using capillary electrophoresis...
April 14, 2018: World Journal of Gastroenterology: WJG
Carina Diniz Rocha, Mayara Mafra Soares, Deize de Cássia Antonino, Jairo Melo Júnior, Renata Ferreira Freitas Mohallem, Ana Paula Ribeiro Rodrigues, José Ricardo Figueiredo, Marcelo Emílio Beletti, José Octavio Jacomini, Benner Geraldo Alves, Kele Amaral Alves
This study aimed to evaluate whether the addition of resveratrol to vitrification/thawing medium improves the cryotolerance of preantral follicles enclosed in bovine ovarian fragments. Ovarian fragments were obtained from bovine fetuses and distributed to the following groups: fresh ovarian fragments (control), vitrified (VIT), and vitrified with resveratrol (VIT + RESV). Overall, the mean percentage of normal follicles was greater (P < 0.05) in the VIT + RESV compared to the VIT group. Moreover, the probability of finding normal follicles was 2...
April 6, 2018: Theriogenology
Herwin Speckter, José Bido, Giancarlo Hernandez, Diones Rivera, Luis Suazo, Santiago Valenzuela, Rafael Fermin, Jairo Oviedo, Bernd Foerster, Cesar Gonzalez, Peter Stoeter
Introduction: In Gamma Knife Radiosurgery (GKRS) of suprasellar lesions, the exact localization of the visual pathways is important to avoid radiation induced optic neuropathy (RION). Reliable identification of the optic nerve, chiasm and tracts can be challenging using routine magnetic resonance imaging, especially in patients with lesions compressing the optic structures or in patients who had prior operation of suprasellar tumors. This study investigates the application of inversion recovery sequences (Fast gray and white matter acquisition T1 inversion recovery, FGATIR) to improve identification of the optic pathway...
2018: Journal of Radiosurgery and SBRT
Jairo A Fonseca, Jessica N McCaffery, Juan Caceres, Elena Kashentseva, Balwan Singh, Igor P Dmitriev, David T Curiel, Alberto Moreno
INTRODUCTION: Cellular and humoral immune responses are both involved in protection against Plasmodium infections. The only malaria vaccine available, RTS,S, primarily induces short-lived antibodies and targets only a pre-erythrocytic stage antigen. Inclusion of erythrocytic stage targets and enhancing cellular immunogenicity are likely necessary for developing an effective second-generation malaria vaccine. Adenovirus vectors have been used to improve the immunogenicity of protein-based vaccines...
April 12, 2018: Vaccine
Victor Pena Ribeiro, Caroline Arruda, Mohamed Abd El-Salam, Jairo Kenupp Bastos
CONTEXT: Inflammatory disorders are common in modern life, and medicinal plants provide an interesting source for new compounds bearing anti-inflammatory properties. In this regard, Brazilian medicinal plants are considered to be a promising supply of such compounds due to their great biodiversity. OBJECTIVES: To undertake a review on Brazilian medicinal plants with corroborated anti-inflammatory activities by selecting data from the literature reporting the efficacy of plants used in folk medicine as anti-inflammatory, including the mechanisms of action of their extracts and isolated compounds...
December 2018: Pharmaceutical Biology
Jairo Rodríguez-Medina, Henar Rodríguez-Navarro, Víctor Arias, Benito Arias, M Teresa Anguera
This mixed-methods study examined differences in social interaction patterns between a school-age boy with autism and his friends, non-reciprocal friends, and non-friends during recess time at a mainstream school (third grade of elementary school). Through a combination of observational methodology and social network analysis with an idiographic, follow-up and multidimensional design approach, we used lag sequential and polar coordinate analysis to ascertain the associations between various interactive behaviors as a function of type of friendship relation...
April 11, 2018: Journal of Autism and Developmental Disorders
Ricardo Andrade Furtado, Pollyanna Francielli de Oliveira, Juliana Marques Senedese, Saulo Duarte Ozelin, Larissa Daniela Ribeiro de Souza, Luís Fernando Leandro, Wendel Luiz de Oliveira, Jonas Joaquim Mangabeira da Silva, Larissa Costa Oliveira, Hervé Rogez, Sérgio Ricardo Ambrósio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Denise Crispim Tavares
The uses of Copaifera species in folk medicine are related to a wide variety of pharmacological properties. This paper reports the cytotoxic and genotoxic analyses of oleoresins and leaves extracts of Copaifera species: C. duckei, C. multijuga, C. paupera, C. pubiflora, C. reticulata and C. trapezifolia. In vitro assays were performed using Chinese hamster lung fibroblasts (V79 cells). The clonogenic efficiency and cytokinesis-block micronucleus assays were employed for the cytotoxicity and genotoxicity assessment, respectively...
April 3, 2018: Journal of Ethnopharmacology
Jairo A Rodríguez, Carlos F Narváez
Hereditary angioedema (HAE) is a heterogeneous genetic disease caused by a deficit in C1 inhibitor (C1-INH) and clinically characterized by sudden events of edema, swelling, and pruritus. Here, we describe the first SERPING1 genotyping in 22 subjects from 4 non-related families, all from southern Colombia. The previously reported heterozygous gene mutations, c.1081C>T (p.Gln361*), c.1396C>G (p.Arg466Gly), c.1029+84G>A, or c.106_107del (p.Ser36Phefs*21), were found in 12 patients. Of note, a single patient clinically characterized as severe HAE type 2 expressed mutations in exon 8 and intron 6, whereas all the others have type 1 HAE and expressed one pathogenic variant...
April 5, 2018: Journal of Clinical Immunology
Reinel Castrillón, Jairo J Pérez, Henry Andrade-Caicedo
BACKGROUND: Wearable textile electrodes for the detection of biopotentials are a promising tool for the monitoring and early diagnosis of chronic diseases. We present a comparative study of the electrical characteristics of four textile electrodes manufactured from common fabrics treated with a conductive polymer, a commercial fabric, and disposable Ag/AgCl electrodes. These characteristics will allow identifying the performance of the materials when used as ECG electrodes. The electrodes were subjected to different electrical tests, and complemented with conductivity calculations and microscopic images to determine their feasibility in the detection of ECG signals...
April 2, 2018: Biomedical Engineering Online
Ivan Mauricio Muñoz-Galindo, Jairo Alexander Moreno Calderón, Natalia Elizabeth Guarín Téllez, Helbert Orlando Arévalo Roa, Jorge Augusto Díaz Rojas
BACKGROUND: There have been many studies on the cost of multiple sclerosis in countries with high prevalence, whereas in Latin America such analyses are few. Taking into consideration the burden of this disease and the high financial impact of treatment on the health care system, it is necessary to know the behavior of cost of illness. OBJECTIVES: To describe the direct costs associated with health care in patients with multiple sclerosis affiliated with a health insurer in Colombia...
March 29, 2018: Value in Health Regional Issues
Santiago Parra Palacio, Clara Elisa Giraldo Hoyos, Camilo Arias Rodríguez, Daniel Mejía Arrieta, John Jairo Vargas Gómez, Alicia Krikorian
PURPOSE: To describe the practice of palliative sedation (PS) in patients with advanced cancer in a specialized palliative care (PC) unit in Colombia. METHODS: Descriptive prospective study including all adults with cancer hospitalized under PS in a cancer institute between January and July 2015 in Colombia. Variables examined were diagnosis, physical functioning, symptoms at the start of sedation, medications and dosages used, and type, level, and time of sedation...
March 29, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Graciela Rodríguez-Sevilla, Marta García-Coca, David Romera-García, John Jairo Aguilera-Correa, Ignacio Mahíllo-Fernández, Jaime Esteban, Concepción Pérez-Jorge
Lung disease in cystic fibrosis (CF) is characterized by the progressive colonization of the respiratory tract by different bacteria, which develop polymicrobial biofilms. In the past decades, there has been an increase in the number of CF patients infected with Non-Tuberculous Mycobacteria (NTM). Although Mycobacterium abscessus is the main NTM isolated globally, little is known about M. abscessus multispecies biofilm formation. In the present study we developed an in vitro model to study the phenotypic characteristics of biofilms formed by M...
April 2018: International Journal of Medical Microbiology: IJMM
Lilian Cristina Pereira, Murilo Pazin, Mariana Furio Franco-Bernardes, Airton da Cunha Martins, Gustavo Rafael Mazzaron Barcelos, Márcio Cesar Pereira, João Paulo Mesquita, Jairo Lisboa Rodrigues, Fernando Barbosa, Daniel Junqueira Dorta
Nanotechnology is a growing branch of science that deals with the development of structural features bearing at least one dimension in the nano range. More specifically, nanomaterials are defined as objects with dimensions that range from 1 to 100 nm, which give rise to interesting properties. In particular, silver and titanium nanoparticles (AgNPs and TiNPs, respectively) are known for their biological and biomedical properties and are often used in consumer products such as cosmetics, food additives, kitchen utensils, and toys...
May 2018: Journal of Trace Elements in Medicine and Biology
Joel Cramer, Felix Fuhrmann, Ulrike Ritzmann, Vanessa Gall, Tomohiko Niizeki, Rafael Ramos, Zhiyong Qiu, Dazhi Hou, Takashi Kikkawa, Jairo Sinova, Ulrich Nowak, Eiji Saitoh, Mathias Kläui
Information transport and processing by pure magnonic spin currents in insulators is a promising alternative to conventional charge-current-driven spintronic devices. The absence of Joule heating and reduced spin wave damping in insulating ferromagnets have been suggested for implementing efficient logic devices. After the successful demonstration of a majority gate based on the superposition of spin waves, further components are required to perform complex logic operations. Here, we report on magnetization orientation-dependent spin current detection signals in collinear magnetic multilayers inspired by the functionality of a conventional spin valve...
March 14, 2018: Nature Communications
Alfredo Perales-Puchalt, Jairo Perez-Sanz, Kyle K Payne, Nikolaos Svoronos, Michael J Allegrezza, Ricardo A Chaurio, Carmen Anadon, Joseph Calmette, Subir Biswas, Jessica A Mine, Tara Lee Costich, Logan Nickels, Jayamanna Wickramasinghe, Melanie R Rutkowski, Jose R Conejo-Garcia
Due to their cytotoxic activities, many anticancer drugs cause extensive damage to the intestinal mucosa and have antibiotic activities. Here, we show that cisplatin induces significant changes in the repertoire of intestinal commensal bacteria that exacerbate mucosal damage. Restoration of the microbiota through fecal-pellet gavage drives healing of cisplatin-induced intestinal damage. Bacterial translocation to the blood stream is correspondingly abrogated, resulting in a significant reduction in systemic inflammation, as evidenced by decreased serum IL-6 and reduced mobilization of granulocytes...
March 14, 2018: Journal of Leukocyte Biology
Raquel Bernardelli Iamaguchi, Renan Lyuji Takemura, Gustavo Bersani Silva, Jairo Andre de Oliveira Alves, Luciano Ruiz Torres, Alvaro Baik Cho, Teng Hsiang Wei, Marcelo Rosa de Rezende, Rames Mattar
INTRODUCTION: Indication of free tissue transfer for limb reconstruction continues to grow, and despite the good results with this treatment option, complications can impair the functional results and cause a raise in health costs, with prolonged hospitalization. Therefore, peri-operative surgical information and comorbidities were described and analyzed, for identification of independent risk factors for complications of free flaps results for traumatic wounds. For our knowledge, intraoperative ischemia time of free flap was not previously studied for post-traumatic limb reconstruction, which could influence results, in these traumatic cases, with the highest rates of complications among microsurgical flap reconstructions...
March 13, 2018: International Orthopaedics
Andréa Silva Garcia de Figueiredo-Rinhel, Micássio Fernandes de Andrade, Ana Paula Landi-Librandi, Ana Elisa Caleiro Seixas Azzolini, Luciana Mariko Kabeya, Jairo Kenupp Bastos, Yara Maria Lucisano-Valim
The aerial parts of Baccharis dracunculifolia (BdE) is used in the Brazilian folk medicine to treat inflammatory conditions. Here we examined the ability of free and liposomal BdE to modulate reactive oxygen species generation in human neutrophils in vitro and zymosan-induced acute joint inflammation in Wistar rats. We prepared biocompatible liposomes of soya phosphatidylcholine and cholesterol with low diameter, homogeneous size distribution, and neutral surface charge. Free BdE decreased joint swelling, total leucocyte and neutrophil infiltration, and the synovial levels of tumour necrosis factor-α and interleukins 6 and 1β...
March 12, 2018: Natural Product Research
Marie Hervé, Bertrand Dupé, Rafael Lopes, Marie Böttcher, Maximiliano D Martins, Timofey Balashov, Lukas Gerhard, Jairo Sinova, Wulf Wulfhekel
Skyrmions are topologically protected non-collinear magnetic structures. Their stability is ideally suited to carry information in, e.g., racetrack memories. The success of such a memory critically depends on the ability to stabilize and manipulate skyrmions at low magnetic fields. The non-collinear Dzyaloshinskii-Moriya interaction originating from spin-orbit coupling drives skyrmion formation. It competes with Heisenberg exchange and magnetic anisotropy favoring collinear states. Isolated skyrmions in ultra-thin films so far required magnetic fields as high as several Tesla...
March 9, 2018: Nature Communications
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