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Cesar Amescua-Garcia, Frantz Colimon, Carlos Guerrero, Aziza Jreige Iskandar, Maria Berenguel Cook, Patricia Bonilla, Durval Campos Kraychete, William Delgado Barrera, Jose Alberto Flores Cantisani, John Jairo Hernandez-Castro, Argelia Lara-Solares, Concepcion Perez Hernandez, Maria Antonieta Rico, Maria Del Rocio Guillen Nunez, Manuel Sempertegui Gallegos, Joao Batista Santos Garcia
Objective: Chronic pain conditions profoundly affect the daily living of a significant number of people and are a major economic and social burden, particularly in developing countries. The Change Pain Latin America (CPLA) advisory panel aimed to identify the most appropriate guidelines for the treatment of neuropathic pain (NP) and chronic low back pain (CLBP) for use across Latin America. Methods: Published systematic reviews or practice guidelines were identified by a systematic search of PubMed, the Guidelines Clearinghouse, and Google...
August 24, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Carmen S Mosquera-Vivas, María J Martinez, Glenda García-Santos, Jairo A Guerrero-Dallos
The adsorption-desorption, hysteresis phenomenon, and leachability of tebuconazole were studied for Inceptisol and Histosol soils at the surface (0-10 cm) and in the subsurface (40-50 cm) of an agricultural region from Colombia by the batch-equilibrium method and mathematical approaches. The experimental Kfa and Kd (L kg(-1)) values (7.9-289.2) decreased with depth for the two Inceptisols and increased with depth for the Histosol due to the organic carbon content, aryl and carbonyl carbon types. Single-point and desorption isotherms depended on adsorption reversibility and suggested that tebuconazole showed hysteresis; which can be adequately evaluated with the single-point desorption isotherm and the linear model using the hysteresis index HI...
September 30, 2017: Chemosphere
Andréa S G Figueiredo-Rinhel, Lamartine L de Melo, Leandro O Bortot, Everton O L Santos, Micássio F Andrade, Ana Elisa C S Azzolini, Luciana M Kabeya, Antonio Caliri, Jairo K Bastos, Yara Maria Lucisano-Valim
OBJECTIVES: To examine whether the hydroalcoholic extract from Baccharis dracunculifolia leaves (BdE) modulates the human neutrophil oxidative metabolism, degranulation, phagocytosis and microbial killing capacity. METHODS: In-vitro assays based on chemiluminescence, spectrophotometry, flow cytometry and polarimetry were used, as well as docking calculations. KEY FINDINGS: At concentrations that effectively suppressed the neutrophil oxidative metabolism elicited by soluble and particulate stimuli (<10 μg/ml), without clear signs of cytotoxicity, BdE (1) inhibited NADPH oxidase and myeloperoxidase activity; (2) scavenged H2 O2 and HOCl; (3) weakly inhibited phagocytosis; and (4) did not affect neutrophil degranulation and microbial killing capacity, the expression levels of TLR2, TLR4, FcγRIIa, FcγRIIIb and CR3 and the activity of elastase and lysozyme...
October 10, 2017: Journal of Pharmacy and Pharmacology
Jairo Arturo Pinzón-Cortés, Angelina Perna-Chaux, Nicolás Steven Rojas-Villamizar, Angelica Diaz-Basabe, Diana Carolina Polania-Villanueva, María Fernanda Jacome, Carlos Olimpo Mendivil, Helena Groot, Valeriano López-Segura
Type 2 diabetes mellitus (T2DM) is characterized by oxidative stress that could lead to chronic micro- and macro-vascular complications. We hypothesized that some of the target organ damage is mediated by oxidative alterations in epigenetic mechanisms involving DNA methylation (5mC) and DNA hydroxymethylation (5hmC). We analyzed global DNA methylation and hydroxymethylation in peripheral blood cells in well-controlled and poorly controlled patients with type 2 diabetes mellitus and compared them to healthy controls...
October 9, 2017: Endocrine Connections
Jairo Vinícius Pinto, Thiago C Moulin, Olavo B Amaral
The search for biomarkers has been a leading endeavor in biological psychiatry. To analyze its evolution over the years, we performed a systematic review to evaluate (a) the most studied peripheral molecular markers in major psychiatric disorders, (b) the main features of studies proposing them as biomarkers and (c) whether their patterns of variation are similar across disorders. Of the six molecules most commonly studied as plasmatic markers of schizophrenia, major depressive disorder or bipolar disorder, five (BDNF, TNF-alpha, IL-6, C-reactive protein and cortisol) were the same across diagnoses...
October 3, 2017: Neuroscience and Biobehavioral Reviews
Caroline Arruda, Daniele de Souza Eugênio, Monique Rodrigues Moreira, Guilherme Venâncio Símaro, Jairo Kenupp Bastos, Carlos Henrique Gomes Martins, Márcio Luís Andrade Silva, Rodrigo Cássio Sola Veneziani, Paula Bruzadelle Vieira, Sérgio R Ambrósio
The biotransformation of the lignan (-)-cubebin by filamentous fungi Aspergillus terreus and Aspergillus niger is an efficient bioprocess for obtaining (-)-hinokinin and (-)-parabenzlactone. The relevance of getting (-)-hinokinin is due to its promising effect against oral pathogens, especially S. sanguinis (both MIC and MBC 12.5 μg/mL), and other previous reported effects against Chagas disease and as anti-inflammatory. The advantage of using fungal transformation is the use of non-toxic and/or non-pollutant reagents and/or solvents in comparison with semi-synthesis...
October 6, 2017: Natural Product Research
Leila das Graças Siqueira, Andréa Maria Eleutério de Barros Lima Martins, Cláudia Mendes Campos Versiani, Lyllian Aparecida Vieira Almeida, Claudemilson da Silva Oliveira, Jairo Evangelista Nascimento, Bárbara Paloma Almeida Alecrim, Rafaela Caetano Bezerra
OBJECTIVE: to assess the quality of the organization and operation of vaccine rooms in Montes Claros, Minas Gerais, Brazil, in 2015. METHODS: descriptive evaluation study on the quality of vaccine rooms, based on the technical guidelines and standards recommended by the National Immunization Program, using a questionnaire adapted from the Evaluation Program of the Vaccine Room Supervision Tool (PAISSV 2.0). RESULTS: all 18 vaccine rooms in the municipality were assessed; regarding the quality concept of the vaccine rooms, six of them were considered ideal, five good, four regular, and three as insufficient...
July 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Ji H Yang, Rui M B Maciel, Claudia C D Nakabashi, Carolina C P S Janovsky, Rosalia P Padovani, Danielle Macellaro, Cléber P Camacho, Akemi Osawa, Jairo Wagner, Rosa Paula M Biscolla
OBJECTIVE: To evaluate the clinical utility of 18F-FDG PET/CT in patients with high-risk DTC. SUBJECTS AND METHODS: Single-center retrospective study with 74 patients with high-risk differentiated thyroid cancer (DTC), classified in 4 groups. Group 1: patients with positive sTg or TgAb, subdivided in Group 1A: negative RxWBS and no foci of metastases identified at conventional image (n = 9); Group 1B: RxWBS not compatible with suspicious foci at conventional image or not proportional to sTg level (n = 13); Group 2: patients with histological findings of aggressive DTC variants (n = 21) and Group 3: patients with positive RxWBS (n = 31)...
September 18, 2017: Archives of Endocrinology and Metabolism
Jairo Castillo-Valenzuela, Edith Martinez-Guerra, Veera Gnaneswar Gude
This article provides an update on the wastewater treatment technologies, which utilize natural processes or passive components to remove various pollutants. The focus is on the wetland systems and their applications in wastewater treatment (as an advanced treatment unit or a decentralized system), and nutrient and pollutant removal (heavy and hazardous metals, industrial and emerging pollutants including pharmaceutical and personal care products and endocrine disrupting chemicals). A summary of studies involving the effects of vegetation, wetland design and operation, modeling, hybrid and innovative systems, storm water treatment, sludge treatment, landfill leachate treatment, and pathogen removal is also included...
October 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
Oscar Hidalgo-Lanussa, Marco Ávila-Rodriguez, Eliana Baez-Jurado, Jairo Zamudio, Valentina Echeverria, Luis Miguel Garcia-Segura, George E Barreto
High concentrations of palmitic acid in plasma increase both the inflammation associated with obesity and the susceptibility to develop a neurodegenerative event. In the brain, the inflammatory response is mediated by activated microglial cells, which undergo morphological and biochemical changes and can directly affect cell viability. Recent evidence shows that the use of estrogenic compounds can control microglia-induced inflammation with promising results. In this study, we explored the actions of the synthetic steroid tibolone on BV-2 microglia cells stimulated with palmitic acid...
September 25, 2017: Molecular Neurobiology
Lucas Fernando Sérgio Gushiken, Carlos Alberto Hussni, Jairo Kenupp Bastos, Ariane Leite Rozza, Fernando Pereira Beserra, Ana Júlia Vieira, Carlos Roberto Padovani, Marivane Lemos, Maurilio Polizello Junior, Jonas Joaquim Mangabeira da Silva, Rafael Henrique Nóbrega, Emanuel Ricardo Monteiro Martinez, Cláudia Helena Pellizzon
The wound healing is a complex process which, sometimes, can be a problem in public health because of the possibility of physical disability or even death. Due to the lack of a gold standard drug in skin wound treatment and aiming at the discovery of new treatments in skin repair and the mechanisms involved in the process, we used oleoresin (OR) from Copaifera langsdorffii and hydroalcoholic extract of the leaves (EH) to treat rat skin wounds. For that, male Wistar rats were divided into groups (n = 8): Lanette, Collagenase, 10% EH, or 10% OR and, after anesthesia, one wound of 2 cm was made in the back of animals...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Mauricio Garcia-Romero, Claudia Geraldine Rita-Gáfaro, Jairo Quintero-Manzano, Anderson Bermon Angarita
INTRODUCTION: An emergency department (ED) is considered to be "overcrowded" when the number of patients exceeds its treatment capacity and it does not have the conditions to meet the needs of the next patient to be treated. This study evaluates overcrowding in the emergency department of a hospital in Colombia. OBJECTIVE: To compare the objective NEDOCS scale with a subjective evaluation by ED health staff in order to evaluate the differences between the two. METHODS: The NEDOCS scale was applied and a subjective overcrowding survey was administered to the medical staff and the charge nurse on duty 6 times per day (6:00 a...
June 30, 2017: Colombia Médica: CM
Hélio Ribeiro, João Paulo C Trigueiro, Wellington M Silva, Cristiano F Woellner, Peter S Owuor, Alin Cristian Chipara, Magnovaldo C Lopes, Chandra S Tiwary, Jairo J Pedrotti, Rodrigo Villegas Salvatierra, James M Tour, Nitin Chopra, Ihab N Odeh, Glaura G Silva, Pulickel M Ajayan
Two-dimensional (2D) nanomaterials as molybdenum disulfide (MoS2), hexagonal boron nitride (h-BN), and their hybrid (MoS2/h-BN) were employed as fillers to improve the physical properties of epoxy composites. Nanocomposites were produced in different concentrations and studied in their microstructure, mechanical and thermal properties. The hybrid 2D mixture imparted efficient reinforcement to the epoxy leading to increases of up to 95% in tensile strength, 60% in ultimate strain, and 58% in Young's modulus...
September 26, 2017: ACS Applied Materials & Interfaces
Laryssa Pinheiro Costa Silva, Jairo Pinto Oliveira, Wanderson Juvencio Keijok, André Romero da Silva, Anderson Rocha Aguiar, Marco Cesar Cunegundes Guimarães, Carolina Magri Ferraz, Jackson Victor Araújo, Fernando Luiz Tobias, Fábio Ribeiro Braga
The biosynthesis of metallic nanoparticles (NPs) using biological systems such as fungi has evolved to become an important area of nanobiotechnology. Herein, we report for the first time the extracellular synthesis of highly stable silver NPs (AgNPs) using the nematophagous fungus Duddingtonia flagrans (AC001). The fungal cell-free filtrate was analyzed by the Bradford method and 3,5-dinitrosalicylic acid assay and used to synthesize the AgNPs in the presence of a 1 mM AgNO3 solution. They have been characterized by UV-Vis spectroscopy, X-ray diffraction, transmission electron microscopy, dynamic light scattering, Zeta potential measurements, Fourier-transform infrared, and Raman spectroscopes...
2017: International Journal of Nanomedicine
David R Janz, Matthew W Semler, Aaron M Joffe, Jonathan D Casey, Robert J Lentz, Bennett P deBoisblanc, Yasin A Khan, Jairo I Santanilla, Itay Bentov, Todd W Rice
BACKGROUND: Hypoxemia and hypotension are common complications during endotracheal intubation of critically ill adults. Verbal performance of a written, preintubation checklist may prevent these complications. We compared a written, verbally performed, preintubation checklist with usual care regarding lowest arterial oxygen saturation or lowest systolic BP experienced by critically ill adults undergoing endotracheal intubation. METHODS: A multicenter trial in which 262 adults undergoing endotracheal intubation were randomized to a written, verbally performed, preintubation checklist (checklist) or no preintubation checklist (usual care)...
September 14, 2017: Chest
Airton da Cunha Martins, Lara Ferreira Azevedo, Cecília Cristina de Souza Rocha, Maria Fernanda Hornos Carneiro, Vinicius Paula Venancio, Mara Ribeiro de Almeida, Lusânia Maria Greggi Antunes, Rodrigo de Carvalho Hott, Jairo Lisboa Rodrigues, Abayomi T Ogunjimi, Joseph A Adeyemi, Fernando Barbosa
The increasing production of silver nanoparticles (AgNPs) and titanium dioxide nanoparticles (TiO2NPs) has resulted in their elevated concentrations in the environment. This study was, therefore, aimed at determining the distribution, redox parameters, and genotoxic effects in male Wistar rats that were treated with either AgNP or TiO2NP individually, as well as under a co-exposure scenario. Animals were exposed via oral gavage to either sodium citrate buffer (vehicle), 0.5 mg/kg/day TiO2NP, 0.5 mg/kg/day AgNP or a mixture of TiO2NPs and AgNPs...
September 11, 2017: Journal of Toxicology and Environmental Health. Part A
Sizina Aguiar G Sales, Maria Luiza Santos, Renato Assis Machado, Verônica Oliveira Dias, Jairo Evangelista Nascimento, Mario Sérgio Oliveira Swerts, Hercílio Martelli Júnior, Daniella Reis Barbosa Martelli
INTRODUCTION: Bifid uvula is a frequently observed anomaly in the general population and can be regarded as a marker for submucous cleft palate. OBJECTIVE: In this study aimed to determine the frequency of bifid uvula and submucous cleft palate and their relationship with oral clefts in a Brazilian population. METHODS: We conducted a transversal, descriptive and quantitative study of 1206 children between August 2014 and December 2015. A clinical examination of the children was conducted by means of inspection of the oral cavity with the aid of a tongue depressor and directed light...
August 24, 2017: Brazilian Journal of Otorhinolaryngology
Daniel Cardona-Correa, Alejandro Ochoa, Edison Muñoz-Ortiz, Jairo Gándara-Ricardo, Juan Pablo Flórez Muñoz
No abstract text is available yet for this article.
September 2, 2017: Archivos de Cardiología de México
Carmen Hermida-Carrera, Mario A Fares, Ángel Fernández, Eustaquio Gil-Pelegrín, Maxim V Kapralov, Arnau Mir, Arántzazu Molins, José Javier Peguero-Pina, Jairo Rocha, Domingo Sancho-Knapik, Jeroni Galmés
Phylogenetic analysis by maximum likelihood (PAML) has become the standard approach to study positive selection at the molecular level, but other methods may provide complementary ways to identify amino acid replacements associated with particular conditions. Here, we compare results of the decision tree (DT) model method with ones of PAML using the key photosynthetic enzyme RuBisCO as a model system to study molecular adaptation to particular ecological conditions in oaks (Quercus). We sequenced the chloroplast rbcL gene encoding RuBisCO large subunit in 158 Quercus species, covering about a third of the global genus diversity...
2017: PloS One
Jairo A Navarrete, Pablo Dartnell
Category Theory, a branch of mathematics, has shown promise as a modeling framework for higher-level cognition. We introduce an algebraic model for analogy that uses the language of category theory to explore analogy-related cognitive phenomena. To illustrate the potential of this approach, we use this model to explore three objects of study in cognitive literature. First, (a) we use commutative diagrams to analyze an effect of playing particular educational board games on the learning of numbers. Second, (b) we employ a notion called coequalizer as a formal model of re-representation that explains a property of computational models of analogy called "flexibility" whereby non-similar representational elements are considered matches and placed in structural correspondence...
August 2017: PLoS Computational Biology
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