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https://www.readbyqxmd.com/read/28194115/low-level-laser-application-in-the-early-myocardial-infarction-stage-has-no-beneficial-role-in-heart-failure
#1
Martha T Manchini, Ednei L Antônio, José Antônio Silva Junior, Paulo de Tarso C de Carvalho, Regiane Albertini, Fernando C Pereira, Regiane Feliciano, Jairo Montemor, Stella S Vieira, Vanessa Grandinetti, Amanda Yoshizaki, Marcio Chaves, Móises P da Silva, Rafael do Nascimento de Lima, Danilo S Bocalini, Bruno L de Melo, Paulo J F Tucci, Andrey J Serra
Low-level laser therapy (LLLT) has been targeted as a promising approach that can mitigate post-infarction cardiac remodeling. There is some interesting evidence showing that the beneficial role of the LLLT could persist long-term even after the end of the application, but it remains to be systematically evaluated. Therefore, the present study aimed to test the hypothesis that LLLT beneficial effects in the early post-infarction cardiac remodeling could remain in overt heart failure even with the disruption of irradiations...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28167160/comparative-study-of-the-cytotoxicity-and-genotoxicity-of-kaurenoic-acid-and-its-semi-synthetic-derivatives-methoxy-kaurenoic-acid-and-kaurenol-in-cho-k1-cells
#2
Bruno Limonti Cano Luiz, Monique Rodrigues Moreira, Mirian Oliveira Goulart, Natália Dos Santos Gonçalves, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Raquel Alves Dos Santos
The diterpene kaurenoic acid (KA) has vasorelaxant, antimicrobial, anti-tumoural and anti-leishmanial effects. Semi-synthetic derivatives were obtained to achieve more satisfactory responses. The assessment of genotoxicity is part of the toxicological evaluation of therapeutic compound candidates. The present study investigated the cytotoxicity and genotoxicity of KA and its semi-synthetic derivatives methoxy kaurenoic acid (MKA) and kaurenol (KRN) using the CHO-K1 cell line. The cytotoxicity evaluation demonstrated that treatments with 200 and 400 μM KA reduced cellular proliferation to 36...
February 3, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28166710/latin-american-guidelines-for-opioid-use-in-chronic-nononcologic-pain
#3
Argelia Lara-Solares, Carlos Aguayo Zamora, César Amescua García, João Batista Santos Garcia, María Del Rosario Berenguel Cook, Patricia Bonilla Sierra, Durval Campos Kraychete, José Alberto Flores Cantisani, Carlos Guerrero, María Del Rocío Guillén Núñez, John Jairo Hernández Castro, Andrés Hernández Ortíz, Aziza Jreige Iskandar, Osvandré Lech, Jacqueline Macías Guerra, Gerardo Ramírez Samayoa, Edwin Rangel Morillo, María Antonieta Rico Pazos, Manuel Sempértegui Gallegos
AIM: Latin-American experts in the use of opioids in patients with chronic nononcologic pain (CNOP) have updated existing recommendations to current Latin-American reality. METHODS: Several key opinion leaders from Latin America participated in a face-to-face meeting in Guatemala (April 2015) to discuss the use of opioids in CNOP. Subgroups of experts worked on specific topics, reviewed the literature and shaped the final manuscript. RESULTS: The expert panel developed guidelines taking into consideration the utility of both opioid and nonopioid analgesics and factors pertaining to their efficacy, safety, adherence, administration and risks for abuse/addiction...
February 7, 2017: Pain Management
https://www.readbyqxmd.com/read/28159515/local-enema-treatment-to-inhibit-folh1-gcpii-as-a-novel-therapy-for-inflammatory-bowel-disease
#4
Abhijit A Date, Rana Rais, Taarika Babu, Jairo Ortiz, Pranjali Kanvinde, Ajit G Thomas, Sarah C Zimmermann, Alexandra J Gadiano, Gilad Halpert, Barbara S Slusher, Laura M Ensign
Here we evaluate the potential for local administration of a small molecule FOLH1/GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) as a novel treatment for inflammatory bowel disease (IBD). We found that FOLH1/GCPII enzyme activity was increased in the colorectal tissues of mice with TNBS-induced colitis, and confirmed that 2-PMPA inhibited FOLH1/GCPII enzyme activity ex vivo. In order to maximize local enema delivery of 2-PMPA, we studied the effect of vehicle tonicity on the absorption of 2-PMPA in the colon...
January 31, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28148909/en-bloc-transplant-of-the-liver-kidney-and-pancreas-experience-from-a-latin-american-transplant-center
#5
Luis A Caicedo, Jorge I Villegas, Oscar Serrano, Mauricio Millán, Mauricio Sepúlveda, Diego Jiménez, Jairo García, Juan G Posada, Liliana Mesa, Carlos Duran, Johanna Schweineberg, Diana Dávalos, Eliana Manzi, Angie Sabogal, Ana María Aristizabal, Gabriel J Echeverri
BACKGROUND En-bloc transplantation is a surgical procedure in which multiple organs are transplanted simultaneously. It has some similarities with multi-organ transplantation but offers certain advantages. This report highlights the experience of our interdisciplinary group regarding the treatment and follow-up of patients who received en-bloc transplantation, with the aim of encouraging the development of this surgical technique. CASE REPORT The first case is a 38-year-old patient with type 1 diabetes mellitus, liver cirrhosis, and chronic kidney failure who received an en-bloc transplant of the liver, pancreas, and kidney with no intraoperative complications...
February 2, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28143566/apoe-genotype-differentially-modulates-effects-of-anti-a%C3%AE-passive-immunization-in-app-transgenic-mice
#6
Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, Jennifer Lopez-Contreras, Jungsu Kim, Patrick M Sullivan, David M Holtzman, Martin J Sadowski
BACKGROUND: APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer's disease (AD). Here we investigated how APOE genotype influences response to anti-Aβ immunotherapy. METHODS: APPSW/PS1dE9 (APP) transgenic mice with targeted replacement of the murine Apoe gene for human APOE alleles received 10D5 anti-Aβ or TY11-15 isotype control antibodies between the ages of 12 and 15 months. RESULTS: Anti-Aβ immunization decreased both the load of fibrillar plaques and the load of Aβ immunopositive plaques in mice of all APOE backgrounds...
January 31, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28140314/-traumatic-luxation-of-crystalline-lens
#7
Germán Espil, Jairo Hernández Pinzón, Nebil Larrañaga, Shigeru Kozima
No abstract text is available yet for this article.
2017: Medicina
https://www.readbyqxmd.com/read/28135897/pharmacokinetic-drug-evaluation-of-vorapaxar-for-secondary-prevention-after-acute-coronary-syndrome
#8
Jose-Angel Perez-Rivera, Jairo Monedero-Campo, Clara Cieza-Borrella, Pablo Ruiz-Perez
Vorapaxar is the first protease-activated receptor-1 inhibitor approved for clinical use. Its main indication is the reduction in thrombotic cardiovascular events in patients with previous myocardial infarction or symptomatic peripheral artery disease. Areas covered: This article reviews the pharmacokinetics of vorapaxar and its potential use in secondary prevention after an acute coronary syndrome. Expert opinion: Vorapaxar inhibits platelet aggregation mediated by thrombin. This effect is carried out without affecting to coagulation parameters and bleeding times...
January 30, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28135612/richness-coverage-and-concentration-of-heavy-metals-in-vascular-epiphytes-along-an-urbanization-gradient
#9
Diego Fedrizzi Petry Becker, Rafael Linden, Jairo Lizandro Schmitt
Richness, coverage and concentration of heavy metals in vascular epiphytes were analyzed in isolated trees along an urbanization gradient in Southern Brazil. A total of 20 phorophytes were sampled in the main street of each site. Concentrations of chromium, cadmium, lead, manganese, nickel and zinc were measured in the leaves of Tillandsia recurvata L. using Graphite Furnace Atomic Absorption Spectrophotometry. A decreasing gradient of epiphyte richness and coverage was observed as urbanization increased. Vehicle fleet and demographic density were the parameters most correlated with the reduction of epiphytic diversity...
January 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28125804/cellular-scaling-rules-for-the-brains-of-marsupials-not-as-primitive-as-expected
#10
Sandra E Dos Santos, Jairo Porfirio, Felipe B da Cunha, Paul R Manger, William Tavares, Leila Pessoa, Mary Ann Raghanti, Chet C Sherwood, Suzana Herculano-Houzel
In the effort to understand the evolution of mammalian brains, we have found that common relationships between brain structure mass and numbers of nonneuronal (glial and vascular) cells apply across eutherian mammals, but brain structure mass scales differently with numbers of neurons across structures and across primate and nonprimate clades. This suggests that the ancestral scaling rules for mammalian brains are those shared by extant nonprimate eutherians - but do these scaling relationships apply to marsupials, a sister group to eutherians that diverged early in mammalian evolution? Here we examine the cellular composition of the brains of 10 species of marsupials...
January 27, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28108940/the-working-alliance-in-psychiatric-care-agreement-communication-and-trust-in-action
#11
Jairo N Fuertes, Arielle Toporovsky, Mariela Reyes
The physician-patient working alliance has been associated with improved patient satisfaction and adherence. However, up until now there has only been a patient form with which to assess the working alliance in medicine. The current study presents the provider form of the physician-patient working alliance, along with psychometric evidence and support. Participants were 106 psychiatrists (61 men and 45 women). They were selected from a database of providers in the Northeast of the U.S. and were asked to complete a mailed survey and to return it in stamped addressed envelope...
January 21, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28107537/correction-gaze-following-is-modulated-by-expectations-regarding-others-action-goals
#12
Jairo Perez-Osorio, Hermann J Müller, Eva Wiese, Agnieszka Wykowska
[This corrects the article DOI: 10.1371/journal.pone.0143614.].
2017: PloS One
https://www.readbyqxmd.com/read/28099864/satb1-expression-governs-epigenetic-repression-of-pd-1-in-tumor-reactive-t-cells
#13
Tom L Stephen, Kyle K Payne, Ricardo A Chaurio, Michael J Allegrezza, Hengrui Zhu, Jairo Perez-Sanz, Alfredo Perales-Puchalt, Jenny M Nguyen, Ana E Vara-Ailor, Evgeniy B Eruslanov, Mark E Borowsky, Rugang Zhang, Terri M Laufer, Jose R Conejo-Garcia
Despite the importance of programmed cell death-1 (PD-1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that the chromatin organizer special AT-rich sequence-binding protein-1 (Satb1) restrains PD-1 expression induced upon T cell activation by recruiting a nucleosome remodeling deacetylase (NuRD) complex to Pdcd1 regulatory regions. Satb1 deficienct T cells exhibited a 40-fold increase in PD-1 expression. Tumor-derived transforming growth factor β (Tgf-β) decreased Satb1 expression through binding of Smad proteins to the Satb1 promoter...
January 17, 2017: Immunity
https://www.readbyqxmd.com/read/28096517/the-nucleoside-analog-clitocine-is-a-potent-and-efficacious-readthrough-agent
#14
Westley J Friesen, Christopher R Trotta, Yuki Tomizawa, Jin Zhuo, Briana Johnson, Jairo Sierra, Bijoyita Roy, Marla Weetall, Jean Hedrick, Josephine Sheedy, James Takasugi, Young-Choon Moon, Suresh Babu, Ramil Baiazitov, John D Leszyk, Thomas W Davis, Stuart W Peltz, Ellen M Welch
Nonsense mutations resulting in a premature stop codon in an open reading frame occur in critical tumor suppressor genes in a large number of the most common forms of cancers and are known to cause or contribute to the progression of disease. Low molecular weight compounds that induce readthrough of nonsense mutations offer a new means of treating patients with genetic disorders or cancers resulting from nonsense mutations. We have identified the nucleoside analog clitocine as a potent and efficacious suppressor of nonsense mutations...
January 17, 2017: RNA
https://www.readbyqxmd.com/read/28051327/are-there-potential-safety-issues-concerning-the-safe-usage-of-electronic-personal-tracking-devices-the-experience-of-a-multi-sport-elite-club
#15
Daniel Medina, Eduard Pons, Antonio Gomez, Marc Guitart, Andres Martin, Jairo Vazquez-Guerrero, Ismael Camenforte, Berta Carles, Roger Font
Despite approval of the use of electronic personal tracking devices (EPTD) during competition by the International Football Association Board (IFAB), other team sport organizations and leagues have banned its use due to "safety concerns", with no evidence to support this assertion. The aim of the current brief report is to provide empirical evidence to support the wide-spread usage across all sports by examining safety issues concerning the use of EPTD in a multi-team sports club. A total of 5 outdoor football teams (first team, second team, under 19, under 18 and first team female) and 3 indoor multi-sport (basketball, futsal and handball) teams have been monitored; accounting for a total of 63...
January 4, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28013356/diuretic-effect-of-extracts-fractions-and-two-compounds-2%C3%AE-3%C3%AE-19%C3%AE-trihydroxy-urs-12-en-28-oic-acid-and-5-hydroxy-3-6-7-8-4-pentamethoxyflavone-from-rubus-rosaefolius-sm-rosaceae-leaves-in-rats
#16
Priscila de Souza, Thaise Boeing, Lincon Bordignon Somensi, Camile Cecconi Cechinel-Zanchett, Jairo Kenupp Bastos, Marcel Petreanu, Rivaldo Niero, Valdir Cechinel-Filho, Luisa Mota da Silva, Sérgio Faloni de Andrade
Although diuretics have been widely used to treat hypertension along with others cardiovascular and renal disorders, no scientific data have been recorded to support the diuretic properties of Rubus rosaefolius Sm. (Rosaceae), a plant popularly used in Brazil to treat hypertension. Male Wistar rats were orally treated with: vehicle; hydrochlorothiazide; aqueous (AERR) and methanolic (MERR) extracts; dichloromethane (DCM), hexane (HEX) and ethyl acetate (EA) fractions; and the isolated compounds 2α,3β,19α-trihydroxy-urs-12-en-28-oic acid (TUA) and 5-hydroxy-3,6,7,8,4'-pentamethoxyflavone (PMF)...
December 24, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28007311/-multivariate-adaptive-regression-splines-mars-an-alternative-for-the-analysis-of-time-series
#17
Jairo Vanegas, Fabián Vásquez
Multivariate Adaptive Regression Splines (MARS) is a non-parametric modelling method that extends the linear model, incorporating nonlinearities and interactions between variables. It is a flexible tool that automates the construction of predictive models: selecting relevant variables, transforming the predictor variables, processing missing values and preventing overshooting using a self-test. It is also able to predict, taking into account structural factors that might influence the outcome variable, thereby generating hypothetical models...
December 19, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27987677/is-there-scientific-evidence-favoring-the-substitution-of-commercially-pure-titanium-with-titanium-alloys-for-the-manufacture-of-dental-implants
#18
REVIEW
Jairo M Cordeiro, Valentim A R Barão
The development of Ti alloys to manufacture dental implants has emerged in recent years due to the increased failure of commercially pure titanium (cpTi) implants. Thus, this study reviews existing information about the mechanical, chemical, electrochemical, and biological properties of the main Ti alloys developed over the past few years to provide scientific evidence in favor of using Ti-based alloys as alternative to cpTi. Ti alloys may be considered viable substitutes in the fabrication of dental implants...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27986193/cost-effectiveness-of-a-care-program-for-hiv-aids-patients-affiliated-with-a-health-insurer-in-colombia-comparing-three-health-care-providers-nationwide
#19
Natalia Elizabeth Guarín Téllez, Jairo Alexander Moreno Calderón, Ivan Mauricio Muñoz-Galindo, Jorge Augusto Díaz Rojas, Helbert Orlando Arévalo Roa
BACKGROUND: In Colombia, HIV and AIDS constitute one of the major diseases of high cost to the health system, making necessary health risk management of patients with this disease through comprehensive health care programs with their respective evaluation of results. OBJECTIVE: To evaluate the relative cost-effectiveness of a care program for patients with HIV/AIDS affiliated to a health insurer in Colombia, comparing their results in three Health care provider (HCP)...
December 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27982286/-healthcare-and-maternal-morbidity-and-mortality-a-hospital-based-case-control-study-in-two-regions-of-colombia-bogot%C3%A3-and-antioquia-2009-2011
#20
Francisco J Yepes, Joaquin G Gómez, John Jairo Zuleta, Juan Luis Londoño, Jorge Luis Acosta-Reyes, Luz Helena Sánchez-Gómez, Marta L Ramírez
The study aimed to identify whether payment forms and insurance schemes are associated with severe obstetric complications and maternal mortality. A hospital-based case-control study was conducted in two regions of Colombia, 2009-2011. Data were obtained from each woman's clinical history. Unconditional logistic regression was used. The sample included 1,011 patients: 337 cases and 674 controls. No quality component was statistically significant in either region. In Bogotá, the risk of obstetric complications was significantly higher in the contributive insurance scheme than in subsidized coverage or uninsured; Antioquia showed similar associations, but not statistically significant...
November 1, 2016: Cadernos de Saúde Pública
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