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https://www.readbyqxmd.com/read/28343079/population-model-of-bladder-motion-and-deformation-based-on-dominant-eigenmodes-and-mixed-effects-models-in-prostate-cancer-radiotherapy
#1
Richard Rios, Renaud De Crevoisier, Juan D Ospina, Frederic Commandeur, Caroline Lafond, Antoine Simon, Pascal Haigron, Jairo Espinosa, Oscar Acosta
In radiotherapy for prostate cancer irradiation of neighboring organs at risk may lead to undesirable side-effects. Given this setting, the bladder presents the largest inter-fraction shape variations hampering the computation of the actual delivered dose vs. planned dose. This paper proposes a population model, based on longitudinal data, able to estimate the probability of bladder presence during treatment, using only the planning computed tomography (CT) scan as input information. As in previously-proposed principal component analysis (PCA) population-based models, we have used the data to obtain the dominant eigenmodes that describe bladder geometric variations between fractions...
March 8, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28342327/influence-of-terrestrial-radionuclides-on-environmental-gamma-exposure-in-a-uranium-deposit-in-para%C3%A3-ba-brazil
#2
José Araújo Dos Santos Júnior, Romilton Dos Santos Amaral, Rômulo Simões Cezar Menezes, Juan Reinaldo Estevez Álvarez, Josineide Marques do Nascimento Santos, Zahily Herrero Fernández, Jairo Dias Bezerra, Alberto Antônio da Silva, Kennedy Francys Rodrigues Damascena, José de Almeida Maciel Neto
One of the main natural uranium deposits in Brazil is located in the municipality of Espinharas, in the State of Paraíba. This area may present high levels of natural radioactivity due to the presence of these radionuclides. Since this is a populated area, there is need for a radioecological dosimetry assessment to investigate the possible risks to the population. Based on this problem, the objective of this study was to estimate the environmental effective dose outdoors in inhabited areas influenced by the uranium deposit, using the specific activities of equivalent uranium, equivalent thorium and (40)K and conversion factors...
March 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28334176/phylogenomic-systematics-of-ostariophysan-fishes-ultraconserved-elements-support-the-surprising-non-monophyly-of-characiformes
#3
Prosanta Chakrabarty, Brant C Faircloth, Fernando Alda, William B Ludt, Caleb D McMahan, Thomas J Near, Alex Dornburg, James S Albert, Jairo Arroyave, Melanie L J Stiassny, Laurie Sorenson, Michael E Alfaro
Ostariophysi is a superorder of bony fishes including more than 10,300 species in 1,100 genera and 70 families. This superorder is traditionally divided into five major groups (orders): Gonorynchiformes (milkfishes and sandfishes), Cypriniformes (carps and minnows), Characiformes (tetras and their allies), Siluriformes (catfishes), and Gymnotiformes (electric knifefishes). Unambiguous resolution of the relationships among these lineages remains elusive, with previous molecular and morphological analyses failing to produce a consensus phylogeny...
February 27, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28329730/synthesis-of-novel-quinoline-based-4-5-dihydro-1h-pyrazoles-as-potential-anticancer-antifungal-antibacterial-and-antiprotozoal-agents
#4
Jonathan Ramírez-Prada, Sara M Robledo, Iván D Vélez, María Del Pilar Crespo, Jairo Quiroga, Rodrigo Abonia, Alba Montoya, Laura Svetaz, Susana Zacchino, Braulio Insuasty
A new series of N-substituted 2-pyrazolines 9a-f, 10a-f, 11a-f, 12a-f and 13a-f were obtained from the cyclocondensation reaction of [(7-chloroquinolin-4-yl)amino]chalcones 8a-f with hydrazine hydrate and its derivatives. Fourteen of the synthesized compounds including the starting chalcones were selected by US National Cancer Institute (NCI) for testing their anticancer activity against 60 different human cancer cell lines, with the most important GI50 values ranging from 0.28 to 11.7 μM (0.13-6.05 μg/mL) and LC50 values ranging from 2...
March 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28316267/efficacy-of-a-computer-based-cognitive-training-program-in-older-people-with-subjective-memory-complaints-a-randomized-study
#5
Angela J Pereira-Morales, Andrés F Cruz Salinas, Jairo Aponte Melo, Francisco Pereira Manrique
OBJECTIVE: the aim of this study was to investigate the effect of computer-assisted cognitive training in healthy older adults with subjective memory complaints. METHODS: 40 older adults, mean age (standard Deviation) = 66.4 (5.6) with subjective memory complaints, were included in this study. Participants were randomly assigned to an Integrated Psychostimulation Program (IPP) (N = 17), a Computerized Cognitive Training (CCT) (N = 12) or a control group (N = 11)...
March 20, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28303543/accelerometer-data-collection-and-processing-criteria-to-assess-physical-activity-and-other-outcomes-a-systematic-review-and-practical-considerations
#6
REVIEW
Jairo H Migueles, Cristina Cadenas-Sanchez, Ulf Ekelund, Christine Delisle Nyström, Jose Mora-Gonzalez, Marie Löf, Idoia Labayen, Jonatan R Ruiz, Francisco B Ortega
BACKGROUND: Accelerometers are widely used to measure sedentary time, physical activity, physical activity energy expenditure (PAEE), and sleep-related behaviors, with the ActiGraph being the most frequently used brand by researchers. However, data collection and processing criteria have evolved in a myriad of ways out of the need to answer unique research questions; as a result there is no consensus. OBJECTIVES: The purpose of this review was to: (1) compile and classify existing studies assessing sedentary time, physical activity, energy expenditure, or sleep using the ActiGraph GT3X/+ through data collection and processing criteria to improve data comparability and (2) review data collection and processing criteria when using GT3X/+ and provide age-specific practical considerations based on the validation/calibration studies identified...
March 16, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28287250/changes-in-the-expression-of-cyclin-dependent-kinase-inhibitors-during-differentiation-of-immortalized-fibroblasts-into-adipocytes
#7
Ibon Alonso, Antonio Baroja, Blanca Fernández, Raquel Vielba, Jon Elorriaga, Jairo Pérez-Sanz, Juan Aréchaga, Juan J Goiriena de Gandarias, Carmen de la Hoz
The mechanisms implicated in the differentiation of fibroblastic precursors into adipocytes can be analyzed in vitro using cell models, such as the 3T3-L1 cell line. Since cell differentiation involves an exit from the cell cycle, it is likely that molecules that inhibit proliferation participate in the control of adipogenesis. This study was aimed at determining the role, if any, of several cyclin-dependent kinase (CDK)-inhibitors and the transcription factor C/EBPα in the process of adipocyte differentitation...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/28251289/determination-of-volatile-compounds-in-cider-apple-juices-using-a-covalently-bonded-ionic-liquid-coating-as-the-stationary-phase-in-gas-chromatography
#8
Jairo Pello-Palma, Jaime González-Álvarez, María Dolores Gutiérrez-Álvarez, Enrique Dapena de la Fuente, Juan José Mangas-Alonso, Daniel Méndez-Sánchez, Vicente Gotor-Fernández, Pilar Arias-Abrodo
A chromatographic method for the separation of volatile compounds in Asturian cider apple juices has been developed. For this separation purpose, a monocationic imidazolium-based ionic liquid bearing a reactive terminal iodine atom was synthesized by a quaternization-anion exchange chemical sequence. Next, the gas chromatography (GC) stationary phase was prepared by covalently linking the imidazolium monolith to the reactive silanol groups of the inner capillary wall at 70 °C. This coated GC column exhibited good thermal stability (290 °C), as well as good efficiency (2000 plates/m) in the separation of volatile compounds from Asturian apple cider juices, and was characterized using the Abraham solvation parameter model...
April 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28242591/critique-of-physical-activity-assessment-between-consumer-and-research-grade-accelerometers-a-comparative-study-in-free-living-conditions
#9
Jairo H Migueles, Cristina Cadenas-Sanchez, Francisco B Ortega
No abstract text is available yet for this article.
February 27, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28240663/68-ga-dotatate-pet-ct-in-nonneuroendocrine-tumors-a-pictorial-essay
#10
Lilian Yuri Itaya Yamaga, Jairo Wagner, Marcelo Buarque de Gusmão Funari
PET-CT with somatostatin analogs labeled with Ga is increasingly recognized as the best imaging modality for the evaluation of well-differentiated neuroendocrine tumors (NETs). However, somatostatin receptor (SSR) is not an exclusive marker for NET. A variety of tumors other than NETs express SSR, leading to a significant risk of false-positive PET/CT results. We illustrate false-positive Ga-DOTATATE PET/CT findings due to high uptake by non-Hodgkin lymphoma, metastatic meningioma, breast cancer, thyroid adenoma, and papillary carcinoma...
February 24, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28236418/one-year-observational-study-of-palivizumab-prophylaxis-on-infants-at-risk-for-respiratory-syncytial-virus-infection-in-latin-america
#11
Leandro Martin Castillo, Gabriela Bugarin, Juan Carlos Arias, Jairo Israel Barajas Rangel, Maria Elina Serra, Nestor Vain
OBJECTIVE: This study aims to describe real world palivizumab use and effectiveness in high-risk Latin American infants and young children. METHOD: Prospective, multicenter observational study with infants at risk for severe RSV infection who received palivizumab according to routine clinical practice. Subjects were followed for one year with monthly visits after the first dose of palivizumab. An infant was considered adherent if receiving all the expected injections or five or fewer injections within appropriate inter-dose intervals...
February 22, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28223724/genomic-variability-of-helicobacter-pylori-isolates-of-gastric-regions-from-two-colombian-populations
#12
Andrés Jenuer Matta, Alvaro Jairo Pazos, Javier Andrés Bustamante-Rengifo, Luis Eduardo Bravo
AIM: To compare the genomic variability and the multiple colonization of Helicobacter pylori (H. pylori) in patients with chronic gastritis from two Colombian populations with contrast in the risk of developing gastric cancer (GC): Túquerres-Nariño (High risk) and Tumaco-Nariño (Low risk). METHODS: Four hundred and nine patients from both genders with dyspeptic symptoms were studied. Seventy-two patients were included in whom H. pylori was isolated from three anatomic regions of the gastric mucosa, (31/206) of the high risk population of GC (Túquerres) and (41/203) of the low risk population of GC (Tumaco)...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28223327/what-is-the-structural-abnormality-in-this-patient
#13
Andrés F Miranda-Arboleda, Jairo Gándara-Ricardo, Edwin F Arévalo-Guerrero, Edison Muñoz-Ortiz
No abstract text is available yet for this article.
February 21, 2017: Circulation
https://www.readbyqxmd.com/read/28194115/low-level-laser-application-in-the-early-myocardial-infarction-stage-has-no-beneficial-role-in-heart-failure
#14
Martha T Manchini, Ednei L Antônio, José Antônio Silva Junior, Paulo de Tarso C de Carvalho, Regiane Albertini, Fernando C Pereira, Regiane Feliciano, Jairo Montemor, Stella S Vieira, Vanessa Grandinetti, Amanda Yoshizaki, Marcio Chaves, Móises P da Silva, Rafael do Nascimento de Lima, Danilo S Bocalini, Bruno L de Melo, Paulo J F Tucci, Andrey J Serra
Low-level laser therapy (LLLT) has been targeted as a promising approach that can mitigate post-infarction cardiac remodeling. There is some interesting evidence showing that the beneficial role of the LLLT could persist long-term even after the end of the application, but it remains to be systematically evaluated. Therefore, the present study aimed to test the hypothesis that LLLT beneficial effects in the early post-infarction cardiac remodeling could remain in overt heart failure even with the disruption of irradiations...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28167160/comparative-study-of-the-cytotoxicity-and-genotoxicity-of-kaurenoic-acid-and-its-semi-synthetic-derivatives-methoxy-kaurenoic-acid-and-kaurenol-in-cho-k1-cells
#15
COMPARATIVE STUDY
Bruno Limonti Cano, Monique Rodrigues Moreira, Mirian Oliveira Goulart, Natália Dos Santos Gonçalves, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Raquel Alves Dos Santos
The diterpene kaurenoic acid (KA) has vasorelaxant, antimicrobial, anti-tumoural and anti-leishmanial effects. Semi-synthetic derivatives were obtained to achieve more satisfactory responses. The assessment of genotoxicity is part of the toxicological evaluation of therapeutic compound candidates. The present study investigated the cytotoxicity and genotoxicity of KA and its semi-synthetic derivatives methoxy kaurenoic acid (MKA) and kaurenol (KRN) using the CHO-K1 cell line. The cytotoxicity evaluation demonstrated that treatments with 200 and 400 μM KA reduced cellular proliferation to 36...
April 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28166710/latin-american-guidelines-for-opioid-use-in-chronic-nononcologic-pain
#16
Argelia Lara-Solares, Carlos Aguayo Zamora, César Amescua García, João Batista Santos Garcia, María Del Rosario Berenguel Cook, Patricia Bonilla Sierra, Durval Campos Kraychete, José Alberto Flores Cantisani, Carlos Guerrero, María Del Rocío Guillén Núñez, John Jairo Hernández Castro, Andrés Hernández Ortíz, Aziza Jreige Iskandar, Osvandré Lech, Jacqueline Macías Guerra, Gerardo Ramírez Samayoa, Edwin Rangel Morillo, María Antonieta Rico Pazos, Manuel Sempértegui Gallegos
AIM: Latin-American experts in the use of opioids in patients with chronic nononcologic pain (CNOP) have updated existing recommendations to current Latin-American reality. METHODS: Several key opinion leaders from Latin America participated in a face-to-face meeting in Guatemala (April 2015) to discuss the use of opioids in CNOP. Subgroups of experts worked on specific topics, reviewed the literature and shaped the final manuscript. RESULTS: The expert panel developed guidelines taking into consideration the utility of both opioid and nonopioid analgesics and factors pertaining to their efficacy, safety, adherence, administration and risks for abuse/addiction...
February 7, 2017: Pain Management
https://www.readbyqxmd.com/read/28159515/local-enema-treatment-to-inhibit-folh1-gcpii-as-a-novel-therapy-for-inflammatory-bowel-disease
#17
Abhijit A Date, Rana Rais, Taarika Babu, Jairo Ortiz, Pranjali Kanvinde, Ajit G Thomas, Sarah C Zimmermann, Alexandra J Gadiano, Gilad Halpert, Barbara S Slusher, Laura M Ensign
Here we evaluate the potential for local administration of a small molecule FOLH1/GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) as a novel treatment for inflammatory bowel disease (IBD). We found that FOLH1/GCPII enzyme activity was increased in the colorectal tissues of mice with TNBS-induced colitis, and confirmed that 2-PMPA inhibited FOLH1/GCPII enzyme activity ex vivo. In order to maximize local enema delivery of 2-PMPA, we studied the effect of vehicle tonicity on the absorption of 2-PMPA in the colon...
January 31, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28148909/en-bloc-transplant-of-the-liver-kidney-and-pancreas-experience-from-a-latin-american-transplant-center
#18
Luis A Caicedo, Jorge I Villegas, Oscar Serrano, Mauricio Millán, Mauricio Sepúlveda, Diego Jiménez, Jairo García, Juan G Posada, Liliana Mesa, Carlos Duran, Johanna Schweineberg, Diana Dávalos, Eliana Manzi, Angie Sabogal, Ana María Aristizabal, Gabriel J Echeverri
BACKGROUND En-bloc transplantation is a surgical procedure in which multiple organs are transplanted simultaneously. It has some similarities with multi-organ transplantation but offers certain advantages. This report highlights the experience of our interdisciplinary group regarding the treatment and follow-up of patients who received en-bloc transplantation, with the aim of encouraging the development of this surgical technique. CASE REPORT The first case is a 38-year-old patient with type 1 diabetes mellitus, liver cirrhosis, and chronic kidney failure who received an en-bloc transplant of the liver, pancreas, and kidney with no intraoperative complications...
February 2, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28143566/apoe-genotype-differentially-modulates-effects-of-anti-a%C3%AE-passive-immunization-in-app-transgenic-mice
#19
Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, Jennifer Lopez-Contreras, Jungsu Kim, Patrick M Sullivan, David M Holtzman, Martin J Sadowski
BACKGROUND: APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer's disease (AD). Here we investigated how APOE genotype influences response to anti-Aβ immunotherapy. METHODS: APPSW/PS1dE9 (APP) transgenic mice with targeted replacement of the murine Apoe gene for human APOE alleles received 10D5 anti-Aβ or TY11-15 isotype control antibodies between the ages of 12 and 15 months. RESULTS: Anti-Aβ immunization decreased both the load of fibrillar plaques and the load of Aβ immunopositive plaques in mice of all APOE backgrounds...
January 31, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28140314/-traumatic-luxation-of-crystalline-lens
#20
Germán Espil, Jairo Hernández Pinzón, Nebil Larrañaga, Shigeru Kozima
No abstract text is available yet for this article.
2017: Medicina
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