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Natalja Vogt, Jean Demaison, Heinz Dieter Rudolph, Marcos Juanes, Jairo Fernández, Alberto Lesarri
The mixed regression method for determination of molecular structures is reviewed and applied to the investigation of ethynylcyclohexane, using both semiexperimental and mass-dependent methods. This methodology provides an efficient and computationally affordable route to obtain accurate molecular reference data, preventing ill-conditioning in the structural least-squares determinations from experimental rotational constants. New supersonic-jet microwave measurements are reported to obtain inertial data for the axial and equatorial species of ethynylcyclohexane, together with all 13 C isotopologues of the equatorial form...
February 14, 2018: Journal of Chemical Physics
Freddy J K Toloza, Jose O Mantilla-Rivas, Maria C Pérez-Matos, Maria L Ricardo-Silgado, Martha C Morales-Alvarez, Jairo A Pinzón-Cortés, Maritza Pérez-Mayorga, Martha L Arévalo-Garcia, Giovanni Tolosa-González, Carlos O Mendivil
Background: Myokines are a group of protein mediators produced by skeletal muscle under stress or physical exertion. Even though their discovery and effects in cell culture and animal models of disease have elicited great enthusiasm, very little is known about their role in human metabolism. We assessed whether plasma concentrations of three known myokines [myonectin, myostatin, and fibroblast-derived growth factor 21 (FGF-21)] would be associated with direct and indirect indicators of insulin resistance (IR) in individuals who did not have a diagnosis of diabetes...
2018: Frontiers in Endocrinology
Maria Bautista, Meilyn Muskus, Adolfo Llinás, Guillermo Bonilla, Carlos Guerrero, Jairo Moyano
BACKGROUND: Previous studies of soft tissue infiltration in hip arthroplasty present variable results. The purpose of this study is to identify whether injection of an analgesic mixture improves pain management during the immediate post-operative period. MATERIALS AND METHODS: This cohort study compared 129 patients that received peri-articular soft tissue injection with 20 ml of 0.25% bupivacaine and 2 ml of ketorolac (30 mg/1 ml) in 28 ml of saline solution, with 71 patients who did not received injections...
February 13, 2018: International Orthopaedics
Andres Rodriguez Zorro, Jairo Hernando Vivas Diaz
Acute appendicitis is one of the most common surgical emergencies in paediatrics. However, acute appendicitis in early infancy is an uncommon condition. Furthermore, strangulation of the small intestine through appendicular knotting is described as very unusual in the literature and is generally not well-diagnosed in the clinical context. This article reports the case of a 23-month-old girl who entered the emergency department with a three-day history of abdominal symptoms and who died in less than 24 hours without receiving surgical intervention...
January 1, 2018: Medicine, Science, and the Law
Romilton Dos Santos Amaral, Elaíze Nídia de Lima Morais, José Araújo Dos Santos Júnior, Arykerne Nascimento Casado da Silva, Jairo Dias Bezerra, Otávio Pereira Dos Santos Junior
A marine phosphorus region with high concentrations of phosphate, coastwise of Pernambuco, Northeast of Brazil, is densely inhabited. Rock phosphate deposits naturally contain uranium ore that produces ionizing radiation from it and its natural descendants, furthermore, its thorium and potassium concentrations are comparable to those usually found in soils. Radiological monitoring of this environment is important to verify the occurrence of harmful effective doses for the adjacent population. This study aimed at the in situ radiometric monitoring in four cities of the north of the Metropolitan Region of Recife-Pernambuco, estimating the effective environmental dose to which the local population is subject...
February 3, 2018: Radiation Protection Dosimetry
Rosimara Gonçalves Leite Vieira, Thaís da Silva Moraes, Larissa de Oliveira Silva, Thamires Chiquini Bianchi, Rodrigo Cassio Sola Veneziani, Sérgio Ricardo Ambrósio, Jairo Kenupp Bastos, Regina Helena Pires, Carlos Henrique Gomes Martins
Background: Patients submitted to hemodialysis therapy are more susceptible to infection, especially to infection by Gram-positive bacteria. Various research works have attempted to discover new antimicrobial agents from plant extracts and other natural products. Methods: The present study aimed to assess the antibacterial activities of Copaifera duckei, C. reticulata, and C. oblongifolia oleoresins; sodium hypochlorite; and peracetic acid against clinical and environmental isolates recovered from a Hemodialysis Unit...
2018: Antimicrobial Resistance and Infection Control
Mohamed Abd El-Salam, Jairo Kenupp Bastos, Jing Jing Han, Daniel Previdi, Eduardo B Coelho, Paulo M Donate, Michael F Romero, John Lieske
The plant metabolite 3,4,5-tri-O-galloylquinic acid methyl ester (TGAME, compound 6) was synthesized and its potential effect on calcium oxalate monohydrate (COM) crystal binding to the surface of Madin-Darby Canine Kidney Cells type I (MDCKI) and crystal growth in a Drosophila melanogaster Malpighian tubule (MT) model was investigated. Membrane, cytosolic and total Annexin A1 (AxA1), α-enolase and heat shock protein 90 (HSP90) amounts were examined by Western blot analysis after subcellular fractionation, then confirmed by immunofluorescence staining of cultured cells...
February 6, 2018: Journal of Medicinal Chemistry
Federico Perdomo-Celis, Felipe Romero, Doris M Salgado, Rocío Vega, Jairo Rodríguez, Juana Angel, Manuel A Franco, Harry B Greenberg, Carlos F Narváez
In this study we identified, at the single-cell level, naturally induced cytokine-producing circulating cells (CPCC) in children with dengue virus (DENV) infection ranging clinically from mild to severe disease. Tumor necrosis factor (TNF)-α- and Interleukin (IL)-6-CPCC were detected in children with primary or secondary acute DENV infection and the pattern of these cytokines was similar to that seen in the supernatant of cultured PBMC and partially comparable to that found in the plasma. Monocytes, B cells (BC), and myeloid dendritic cells (mDC) were the primary CPCC detected, and the frequency of mDC was significantly higher in severe disease...
January 30, 2018: Journal of Infectious Diseases
Miguel Saps, Jairo Enrique Moreno-Gomez, Carmen Rossy Ramírez-Hernández, John M Rosen, Carlos A Velasco-Benitez
INTRODUCTION: Functional gastrointestinal disorders (FGIDs) are highly prevalent worldwide and are thought to result from the interplay of multiple factors that can vary from region to region. Nationwide studies can help understand the regional epidemiology and the pathogenesis of FGIDs. The objectives of this study were to determine the prevalence of FGIDs in school-children of Colombia and assess associated factors. METHODS: A cross-sectional study was carried out at twelve private and public schools in ten cities distributed through the four main geographic regions of Colombia...
November 2017: Boletín Médico del Hospital Infantil de México
Fadi Soukarieh, Eduard Vico Oton, Jean-Frédéric Dubern, Janice Gomes, Nigel Halliday, Maria de Pilar Crespo, Jonathan Ramírez-Prada, Braulio Insuasty, Rodrigo Abonia, Jairo Quiroga, Stephan Heeb, Paul Williams, Michael J Stocks, Miguel Cámara
Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis, wound and nosocomial infections, posing a serious burden to public health, due to its antibiotic resistance. The P. aeruginosa Pseudomonas Quinolone System (pqs) quorum sensing system, driven by the activation of the transcriptional regulator, PqsR (MvfR) by alkylquinolone (AQ) signal molecules, is a key player in the regulation of virulence and a potential target for the development of novel antibacterial agents. In this study, we performed in silico docking analysis, coupled with screening using a P...
January 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jairo Greco Garcia, Adriano Martinez, Reynaldo Jesus Garcia Filho, Marcelo Toledo Petrilli, Dan Carai Viola
Objective: Describe the epidemiological profile of patients with primary or secondary neoplastic lesions in the pelvis who required a surgical procedure such as hemipelvectomy. Methods: This study retrospectively evaluated 69 patients located in the database of a São Paulo educational institution, subject to surgical hemipelvectomy treatment between January 1990 and December 2013. All patients had previous diagnosis of bone tumor (primary or metastatic) in the pelvis (ilium, ischium, pubis, and/or sacrum)...
January 2018: Revista Brasileira de Ortopedia
Raimundo Barbosa-Barros, Andrés R Pérez-Riera, Kimmo Koivula, Jairo de Carvalho Santos, Luiz C de Abreu, Kjell Nikus
Aortitis is one of many possible manifestations of tertiary syphilis. Aortic disease is the most common of all cardiovascular syphilitic lesions. Aortic diseases caused by tertiary syphilis include aortitis, aortic root dilation, aneurysm formation, aortic regurgitation and coronary ostial stenosis. A less common manifestation of syphilitic aortitis is coronary artery ostial narrowing related to aortic wall thickening. We report a case of a 40-year-old male patient admitted with a clinical picture of acute coronary syndrome (unstable angina)...
January 21, 2018: Annals of Noninvasive Electrocardiology
Jairo N Fuertes, Michael Moore, Jennifer Ganley
OBJECTIVE: While there has been much research on the role of the working alliance in psychotherapy, researchers only recently began investigating the role of the real relationship in treatment. METHODS: In the current study on therapist and client dyads, we used actor-partner interdependence modeling (APIM) to examine associations between therapists' and clients' ratings of the real relationship, therapist self-disclosure, attachment, and treatment progress. APIM analyses allowed for an examination into how therapists' and clients' views of a particular phenomenon might affect their own ratings (actor), as well as the others' (partner) ratings of that same phenomenon...
January 20, 2018: Psychotherapy Research: Journal of the Society for Psychotherapy Research
Jairo Arturo Noreña, César Daniel Niño, Sabrina Gallego, Carlos Alfonso Builes-Barrera, Diva Cristina Castro, Alejandro Román-González, Camilo Jimenez
Soft-tissue filler (STF) injections have been used worldwide for cosmetic reasons. In most cases, they are not approved by the United States Food and Drug Administration (FDA). Regulatory boards in Latin American countries do not allow the medical use of STF injections; however, these injections are still widely used. A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented. The reported case highlights the consequences of STF use, including calcitriol-mediated hypercalcemia secondary to granulomatous reactions years after an esthetic procedure...
September 2017: Clinical Cases in Mineral and Bone Metabolism
Julio Acuña, Jhoan Piermattey, Daneiva Caro, Sven Bannwitz, Luis Barrios, Jairo López, Yanet Ocampo, Ricardo Vivas-Reyes, Fabio Aristizábal, Ricardo Gaitán, Klaus Müller, Luis Franco
Colorectal cancer (CRC) is a disease with high incidence and mortality, constituting the fourth most common cause of death from cancer worldwide. Naphthoquinones are attractive compounds due to their biological and structural properties. In this work, 36 naphthoquinone derivatives were synthesized and their activity evaluated against HT-29 cells. Overall, high to moderate anti-proliferative activity was observed in most members of the series, with 15 compounds classified as active (1.73 < IC50 < 18.11 μM)...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Kyoung-Whan Kim, Kyung-Jin Lee, Jairo Sinova, Hyun-Woo Lee, M D Stiles
We use a perturbative approach to study the effects of interfacial spin-orbit coupling in magnetic multilayers by treating the two-dimensional Rashba model in a fully three-dimensional description of electron transport near an interface. This formalism provides a compact analytic expression for current-induced spin-orbit torques in terms of unperturbed scattering coefficients, allowing computation of spin-orbit torques for various contexts, by simply substituting scattering coefficients into the formulas. It applies to calculations of spin-orbit torques for magnetic bilayers with bulk magnetism, those with interface magnetism, a normal metal/ferromagnetic insulator junction, and a topological insulator/ferromagnet junction...
September 2017: Physical Review. B
Jacqueline Morais Alves, Luís Fernando Leandro, Juliana Marques Senedese, Pâmela Tinti de Castro, Daiane Eleutério Pereira, Flávia Aparecida Resende, Débora Leite Campos, Jonas Joaquim Mangabeira da Silva, Eliana Aparecida Varanda, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Denise Crispim Tavares
In view of the biological activities and growing therapeutic interest in oleoresin obtained from Copaifera multijuga, this study aimed to determine the genotoxic and antigenotoxic potential of this oleoresin (CMO) and its chemical marker, diterpene (-)-copalic acid (CA). The micronucleus (MN) assay in V79 cell cultures and the Ames test were used for in vitro analyses, as well as MN and comet assays in Swiss mice for in vivo analyses. The in vitro genotoxicity/mutagenicity results showed that either CMO (30, 60, or 120 µg/ml-MN assay; 0...
December 29, 2017: Journal of Toxicology and Environmental Health. Part A
Patricia Martin-Romano, Iosune Baraibar, Jaime Espinós, Jairo Legaspi, Jose M López-Picazo, Jose Manuel Aramendía, Oscar A Fernández, Marta Santisteban
The combination of Pegylated Liposomal Doxorubicin (PLD) plus Gemcitabine (GEM) has been previously investigated in the treatment of metastatic breast cancer (MBC). PLD is a doxorubicin formulation with prolonged circulation time and better tissue distribution. GEM is a nucleoside analog with nonoverlapping toxicity compared to PLD. The aim of our study was to assess efficacy, toxicity, and long-term outcome of this combination. Patients with heavily treated MBC were retrospectively analyzed. Chemotherapy consisted of PLD 25 mg/m2 and GEM 800 mg/m2 day 1, on a three-week schedule...
December 29, 2017: Breast Journal
Jose D Alarcon, Andres M Rubiano, David O Okonkwo, Jairo Alarcón, Maria José Martinez-Zapata, Gerard Urrútia, Xavier Bonfill Cosp
BACKGROUND: Traumatic brain injury (TBI) is a major public health problem and a fundamental cause of morbidity and mortality worldwide. The burden of TBI disproportionately affects low- and middle-income countries. Intracranial hypertension is the most frequent cause of death and disability in brain-injured people. Special interventions in the intensive care unit are required to minimise factors contributing to secondary brain injury after trauma. Therapeutic positioning of the head (different degrees of head-of-bed elevation (HBE)) has been proposed as a low cost and simple way of preventing secondary brain injury in these people...
December 28, 2017: Cochrane Database of Systematic Reviews
Luis Alberto Illicachi, Joel José Montalvo-Acosta, Alberto Insuasty, Jairo Quiroga, Rodrigo Abonia, Maximiliano Sortino, Susana Zacchino, Braulio Insuasty
Novel (E)-1-(aryl)-3-(4-(2-(dimethylamino)ethoxy)-3-methoxyphenyl) prop-2-en-1-ones 4 were synthesized by a Claisen-Schmidt reaction of 4-(2-(dimethylamino)ethoxy)-3-methoxy-benzaldehyde (2) with several acetophenone derivatives 3. Subsequently, cyclocondensation reactions of chalcones 4 with hydrazine hydrate afforded the new racemic 3-aryl-5-(4-(2-(dimethylamino)ethoxy)-3-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehydes 5 when the reaction was carried out in formic acid. The antifungal activity of both series of compounds against eight fungal species was determined...
September 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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