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https://www.readbyqxmd.com/read/29234095/enclaves-of-genetic-diversity-resisted-inca-impacts-on-population-history
#1
Chiara Barbieri, José R Sandoval, Jairo Valqui, Aviva Shimelman, Stefan Ziemendorff, Roland Schröder, Maria Geppert, Lutz Roewer, Russell Gray, Mark Stoneking, Ricardo Fujita, Paul Heggarty
The Inca Empire is claimed to have driven massive population movements in western South America, and to have spread Quechua, the most widely-spoken language family of the indigenous Americas. A test-case is the Chachapoyas region of northern Peru, reported as a focal point of Inca population displacements. Chachapoyas also spans the environmental, cultural and demographic divides between Amazonia and the Andes, and stands along the lowest-altitude corridor from the rainforest to the Pacific coast. Following a sampling strategy informed by linguistic data, we collected 119 samples, analysed for full mtDNA genomes and Y-chromosome STRs...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228012/correction-positively-selected-amino-acid-replacements-within-the-rubisco-enzyme-of-oak-trees-are-associated-with-ecological-adaptations
#2
Carmen Hermida-Carrera, Mario A Fares, Ángel Fernández, Eustaquio Gil-Pelegrín, Maxim V Kapralov, Arnau Mir, Arántzazu Molins, José Javier Peguero-Pina, Jairo Rocha, Domingo Sancho-Knapik, Jeroni Galmés
[This corrects the article DOI: 10.1371/journal.pone.0183970.].
2017: PloS One
https://www.readbyqxmd.com/read/29206122/synthesis-of-spiro-indoline-3-3-pyrrolizines-by-1-3-dipolar-reactions-between-isatins-l-proline-and-electron-deficient-alkenes
#3
Jairo Quiroga, Pablo Romo, Justo Cobo, Christopher Glidewell
Two spiro[indoline-3,3'-pyrrolizine] derivatives have been synthesized in good yield with high regio- and stereospecificity using one-pot reactions between readily available starting materials, namely L-proline, substituted 1H-indole-2,3-diones and electron-deficient alkenes. The products have been fully characterized by elemental analysis, IR and NMR spectroscopy, mass spectrometry and crystal structure analysis. In (1'RS,2'RS,3SR,7a'SR)-2'-benzoyl-1-hexyl-2-oxo-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizine]-1'-carboxylic acid, C28H32N2O4, (I), the unsubstituted pyrrole ring and the reduced spiro-fused pyrrole ring adopt half-chair and envelope conformations, respectively, while in (1'RS,2'RS,3SR,7a'SR)-1',2'-bis(4-chlorobenzoyl)-5,7-dichloro-2-oxo-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizine], which crystallizes as a partial dichloromethane solvate, C28H20Cl4N2O3·0...
December 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29199411/the-phospholipid-linoleoylglycerophosphocholine-as-a-biomarker-of-directly-measured-insulin-resistance
#4
Maria Camila Pérez-Matos, Martha Catalina Morales-Álvarez, Freddy Jean Karlo Toloza, Maria Laura Ricardo-Silgado, Jose Oscar Mantilla-Rivas, Jairo Arturo Pinzón-Cortes, Maritza Perez-Mayorga, Elizabeth Jiménez, Edwin Guevara, Carlos O Mendivil
BACKGROUND: Plasma concentrations of some lysophospholipids correlate with metabolic alterations in humans, but their potential as biomarkers of insulin resistance (IR) is insufficiently known. We aimed to explore the association between plasma linoleoylglycerophosphocholine (LGPC) and objective measures of IR in adults with different metabolic profiles. METHODS: We studied 62 men and women, ages 30 to 69 years, (29% normal weight, 59% overweight, 12% obese). Participants underwent a 5-point oral glucose tolerance test (5p-OGTT) from which we calculated multiple indices of IR and insulin secretion...
November 27, 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29196122/venoms-of-centruroides-and-tityus-species-from-panama-and-their-main-toxic-fractions
#5
Marcos H Salazar, Iván Arenas, Ligia L Corrales-García, Roberto Miranda, Sara Vélez, Jairo Sánchez, Karla Mendoza, John Cleghorn, Fernando Z Zamudio, Adolfo Castillo, Lourival D Possani, Gerardo Corzo, Hildaura Acosta
The scorpionism in Panama is notorious for the confluence and coexistence of buthid scorpions from the genera Centruroides and Tityus. This communication describes an overview of the larger representative toxic venom fractions from eight dangerous buthid scorpion species of Panama: Centruroides (C. granosus, C. bicolor, C. limbatus and C. panamensis) and Tityus (T. (A.) asthenes, T. (A.) festae, T. (T.) cerroazul and T. (A.) pachyurus). Their venoms were separated by HPLC and the corresponding sub-fractions were tested for lethality effects on mice and insects...
November 28, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29195910/dispelling-myths-about-connexins-pannexins-and-p2%C3%A3-7-in-hypoxic-ischemic-central-nervous-system
#6
REVIEW
Pedro Henrique Moreira de Freitas, Natiele Carla da Silva Ferreira, Jairo Guedes Fioravante-Rezende, Laura de Menezes Santos, Luiz Anastacio Alves, Renato Rozental
In membrane physiology, as in other fields, myths or speculations may be repeated so often and so widely that they are perceived as facts. To some extent, this has occurred with regard to gap junctions, hemichannels, pannexin channels and P2×7 (ionotropic receptors), especially concerning the interpretation of the individual role of these channels in hypoxic-ischemic CNS since these channels may be closed by the same pharmacological blockers. Significance of existing controversial data are highlighted and contradictory views from different groups are critically discussed herein...
November 28, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29172838/in-vitro-schistosomicidal-activity-of-the-lignan-6-6-dinitrohinokinin-dnhk-loaded-into-poly-lactic-co-glycolic-acid-nanoparticles-against-schistosoma-mansoni
#7
Thaís C Lima, Rodrigo Lucarini, Priscilla P Luz, Emerson H de Faria, Liziane Marçal, Lizandra G Magalhães, Fernanda R Badoco, Viviane R Esperandim, Eduardo F Molina, Rosangela S Laurentz, Regiane G Lima, Wilson R Cunha, Jairo K Bastos, Marcio L Andrade Silva
CONTEXT: (-)-6,6'-Dinitrohinokinin (DNHK) display remarkable antiparasitic activity and was, therefore, incorporated into a nanoparticle formulation. OBJECTIVE: Incorporation of DNHK in poly lactic-co-glycolic acid (PLGA) nanoparticles aiming to improve its biological activities. MATERIALS AND METHODS: Synthesis, characterization and incorporation of DNHK into glycolic acid (PLGA) nanoparticles by nanoprecipitation method. The nanoparticles were characterized by ultraviolet-visible spectroscopy, X-ray diffraction, field emission electron microscopic scanning mansoni (FESEM), and dynamic light scattering (DLS)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29169733/use-of-copaifera-multijuga-for-acute-corneal-repair-after-chemical-injury-a-clinical-histopathological-and-toxicogenetic-study
#8
Fernanda Gosuen Gonçalves Dias, Adriana Torrecilhas Jorge, Lucas de Freitas Pereira, Ricardo Andrade Furtado, Sérgio Ricardo Ambrósio, Jairo Kenupp Bastos, Salvador Boccaletti Ramos, Fernando Chahud, Luis Gustavo Gosuen Gonçalves Dias, Cristiane Dos Santos Honsho, Denise Crispim Tavares
Copaiba oil is widely used in medicine, but there are no reports regarding its application in ophthalmology. Therefore, the objective of this study was to evaluate the clinical, histopathological and toxicogenetic effects of eye drops containing 0.1 and 0.5% of Copaifera multijuga Hayne oil on superficial corneal ulcers induced with alkali in the left eye of rats. For histological analysis, the percent reduction in ulcers and thickness of the corneal epithelium and stroma were evaluated 48 and 72 h after ulcer induction...
November 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29141790/cerebral-toxoplasmosis-in-an-ms-patient-receiving-fingolimod
#9
Alejandro Enriquez-Marulanda, Jaime Valderrama-Chaparro, Laura Parrado, Juan Diego Vélez, Ana Maria Granados, Jorge Luis Orozco, Jairo Quiñones
Multiple Sclerosis (MS) is an autoimmune disease in which lymphocytes target putative myelin antigens in the CNS, causing inflammation and neurodegeneration. Fingolimod (FTY720) is an immunosuppressive drug used as a second line therapy for relapsing forms of MS due to its safety profile and good response to treatment. Despite its safety, there are still concerns about the possibility of Fingolimod being linked to the development of opportunistic infections like disseminated varicella zoster infections and herpes simplex encephalitis...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29136791/a-flow-injection-procedure-using-layered-double-hydroxide-for-on-line-pre-concentration-of-fluoride
#10
Diego P Rocha, Gabriel C Terra, Thaís S Nery, Jairo Tronto, Frederico G Pinto, Sidnei G Silva, Nívia M M Coelho
This work showed a flow system designed with solenoid valves for preconcentration of fluoride using SPADNS method in water samples. The analyte was preconcentrated in a mini-column coated with Layered Double Hydroxides (LDH) used as adsorbent. Then, the fluoride ions were eluted with 0.5molL(-1) sodium hydroxide and determined by spectrophotometry. The variables that affect the system such adsorbent mass, type of eluent, solutions flow rate, reagent concentration and pH effect were critically evaluated. Under optimized conditions, the detection limit, coefficient of variation, linear range and preconcentration factor were estimated at 15µgL(-1) (99...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29125022/number-of-days-required-for-reliably-estimating-physical-activity-and-sedentary-behaviour-from-accelerometer-data-in-older-adults
#11
Jeffer Eidi Sasaki, Jairo Hélio Júnior, Joilson Meneguci, Sheilla Tribess, Moacir Marocolo Júnior, Antonio Stabelini Neto, Jair Sindra Virtuoso Júnior
The purpose of the study was to examine the minimum number of monitoring days for reliably estimating physical activity (PA) and sedentary behaviour (SB) from accelerometer data in older adults. Forty-two older adults from a local senior centre participated in this study. Participants wore an ActiGraph wGT3X-BT on the right hip for 7 consecutive days. Accelerometer data were downloaded to a computer and converted to activity count data in 60s epochs. Time spent in SB and different PA intensity categories were estimated with commonly used activity count cut-points...
November 10, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29120094/visitor-effect-on-the-behavior-of-a-group-of-spider-monkeys-ateles-geoffroyi-maintained-at-an-island-in-lake-catemaco-veracruz-mexico
#12
Sergio Pérez-Galicia, Manuel Miranda-Anaya, Domingo Canales-Espinosa, Jairo Muñoz-Delgado
We analyzed the effect of human visitors on the behavior of a group of spider monkeys (Ateles geoffroyi) kept on a small tourist island. Although the spider monkey is a common species in zoos, there are very few specific studies on visitor effects on these monkeys. We conducted behavioral observations on the group of spider monkeys to evaluate the effect of visitors. We also used actimetry devices to measure the variations in the spider monkeys' locomotor activity associated with human presence. With regard to the effect on behavior, we found an increase in self-directed behaviors and a decrease in vocalization, both associated with human presence...
November 9, 2017: Zoo Biology
https://www.readbyqxmd.com/read/29110098/do-hydrodynamically-assisted-binary-collisions-lead-to-orientational-ordering-of-microswimmers
#13
Norihiro Oyama, John Jairo Molina, Ryoichi Yamamoto
We have investigated the onset of collective motion in systems of model microswimmers, by performing a comprehensive analysis of the binary collision dynamics using three-dimensional direct numerical simulations (DNS) with hydrodynamic interactions. From this data, we have constructed a simplified binary collision model (BCM) which accurately reproduces the collective behavior obtained from the DNS for most cases. Thus, we show that global alignment can mostly arise solely from binary collisions. Although the agreement between both models (DNS and BCM) is not perfect, the parameter range in which notable differences appear is also that for which strong density fluctuations are present in the system (where pseudo-sound mound can be observed (N...
November 8, 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29106570/the-ucsc-genome-browser-database-2018-update
#14
Jonathan Casper, Ann S Zweig, Chris Villarreal, Cath Tyner, Matthew L Speir, Kate R Rosenbloom, Brian J Raney, Christopher M Lee, Brian T Lee, Donna Karolchik, Angie S Hinrichs, Maximilian Haeussler, Luvina Guruvadoo, Jairo Navarro Gonzalez, David Gibson, Ian T Fiddes, Christopher Eisenhart, Mark Diekhans, Hiram Clawson, Galt P Barber, Joel Armstrong, David Haussler, Robert M Kuhn, W James Kent
The UCSC Genome Browser (https://genome.ucsc.edu) provides a web interface for exploring annotated genome assemblies. The assemblies and annotation tracks are updated on an ongoing basis-12 assemblies and more than 28 tracks were added in the past year. Two recent additions are a display of CRISPR/Cas9 guide sequences and an interactive navigator for gene interactions. Other upgrades from the past year include a command-line version of the Variant Annotation Integrator, support for Human Genome Variation Society variant nomenclature input and output, and a revised highlighting tool that now supports multiple simultaneous regions and colors...
November 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29105850/cost-effectiveness-analysis-of-interventions-for-prevention-of-invasive-aspergillosis-among-leukemia-patients-during-hospital-construction-activities
#15
Juan Felipe Combariza, Luis Fernando Toro, John Jairo Orozco, Marcos Arango
OBJECTIVES: Invasive Aspergillosis (IA) is a serious problem among hematological patients and it is associated with high mortality. This situation can worsen at times of hospital construction, however there are several preventive measures available. This work aims to define the cost-effectiveness of some of these interventions. PATIENTS AND METHODS: A decision tree model was used, it was divided into four arms according to each one of the interventions performed...
November 6, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29102177/a-schmidt-rearrangement-mediated-synthesis-of-novel-tetrahydro-benzo-1-4-diazepin-5-ones-as-potential-anticancer-and-antiprotozoal-agents
#16
Daniel Insuasty, Sara M Robledo, Iván D Vélez, Paola Cuervo, Braulio Insuasty, Jairo Quiroga, Manuel Nogueras, Justo Cobo, Rodrigo Abonia
Novel tetrahydro-5H-benzo[e][1,4]diazepin-5-ones, several of them, containing the quinoline pharmacophore, were synthesized via a Schmidt rearrangement from their corresponding 1,2,3,4-tetrahydro-4-quinolones mediated by the NaN3/H2SO4 reaction conditions. Twelve of the obtained compounds were in vitro screened by the US National Cancer Institute (NCI) for their ability to inhibit 60 different human tumor cell lines, where compound 24a presented a remarkable activity against 58 of the 60 cancer cell lines, with the most important GI50 values ranging from 0...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29100179/modeling-whole-body-trace-metal-concentrations-in-aquatic-invertebrate-communities-a-trait-based-approach
#17
Dorothea Hug Peter, Sylvain Sardy, Jairo Diaz Rodriguez, Emmanuel Castella, Vera I Slaveykova
Trace metal risk assessment and environmental quality standard definition require realistic models that quantify metal exposure and accumulation by biota. In the present study we propose a novel trait-based approach to predict whole body concentrations of metals in aquatic invertebrates from concentrations measured in different environmental compartments. Field data from a large riverine floodplain was used to calibrate and test the model. The prediction performance of the trait-based model was unbiased and uncertainty was below the twofold of measured concentrations for the four studied metals (Ni, Cu, Cd, Pb)...
October 31, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29069139/elemental-composition-of-vegetables-cultivated-over-coal-mining-waste
#18
Jairo J Zocche, Paula Rohr, Adriani P Damiani, Daniela D Leffa, Miriam C Martins, Caroline M Zocche, Karina O Teixeira, Gabriela D Borges, Maiellen M DE Jesus, Carla E I Dos Santos, Johnny F Dias, Vanessa M DE Andrade
We assessed elemental composition of the liver in mice subjected to one-time or chronic consumption of the juice of vegetables cultivated in a vegetable garden built over deposits of coal waste. Lactuca sativa L. (lettuce), Beta vulgaris L. (beet), Brassica oleracea L. var. italica (broccoli) and Brassica oleracea L. var. acephala (kale) were collected from the coal-mining area and from a certified organic farm (control). Elemental composition was analyzed by particle-induced X-ray emission (PIXE) method. Concentrations of Mg, S, and Ca of mice subjected to one-time consumption of broccoli and concentrations of these same elements plus Si of mice receiving kale were higher in the coal-mining area...
October 23, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29058169/chronic-exercise-reduces-cetp-and-mesterolone-treatment-counteracts-exercise-benefits-on-plasma-lipoproteins-profile-studies-in-transgenic-mice
#19
Andrea Camargo Casquero, Jairo Augusto Berti, Laura Lauand Sampaio Teixeira, Helena Coutinho Franco de Oliveira
Regular exercise and anabolic androgenic steroids have opposing effects on the plasma lipoprotein profile and risk of cardio-metabolic diseases in humans. Studies in humans and animal models show conflicting results. Here, we used a mice model genetically modified to mimic human lipoprotein profile and metabolism. They under-express the endogenous LDL receptor gene (R1) and express a human transgene encoding the cholesteryl ester transfer protein (CETP), normally absent in mice. The present study was designed to evaluate the independent and interactive effects of testosterone supplementation, exercise training and CETP expression on the plasma lipoprotein profile and CETP activity...
October 20, 2017: Lipids
https://www.readbyqxmd.com/read/29047160/mutations-in-the-genes-for-keratin-4-and-13-in-swedish-patients-with-white-sponge-nevus
#20
Maria Westin, Elham Rekabdar, Lena Blomstrand, Per Klintberg, Mats Jontell, Jairo Robledo-Sierra
BACKGROUND: White sponge nevus is a rare autosomal dominant disorder that affects the non-keratinised stratified squamous epithelium. Mutations in the genes that encode mucosa-specific keratins 4 and 13 are strongly linked to the manifestation of white sponge nevus. This study involved mutational analysis of the genes encoding keratin-4 and keratin-13 in two Swedish families with white sponge nevus. METHODS: The diagnosis of white sponge nevus was based on disease history, clinical characteristics of the lesions and, in the majority of the cases, histopathological examination...
October 19, 2017: Journal of Oral Pathology & Medicine
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