Cecile Riviere-Cazaux, Karishma Rajani, Masum Rahman, Juhee Oh, Desmond A Brown, Jaclyn F White, Benjamin T Himes, Ignacio Jusue-Torres, Moses Rodriguez, Arthur E Warrington, Sani H Kizilbash, William F Elmquist, Terry C Burns
BACKGROUND: Microdialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in primary malignant brain tumors known as gliomas. Gliomas are mainly accessible at the time of surgery, but have rarely been analyzed via interstitial fluid collected via microdialysis. To that end, we obtained an investigational device exemption for high molecular weight catheters (HMW, 100 kDa) and a variable flow rate pump to perform microdialysis at flow rates amenable to an intra-operative setting...
December 19, 2023: Fluids and Barriers of the CNS