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https://www.readbyqxmd.com/read/29347701/speed-of-light-pulses-in-the-massless-nonlinear-dirac-equation-with-a-potential
#1
Niurka R Quintero, Franz G Mertens, Fred Cooper, Avadh Saxena, A R Bishop
We consider the massless nonlinear Dirac (NLD) equation in 1+1 dimension with scalar-scalar self-interaction g^{2}/2(Ψ[over ¯]Ψ)^{2} in the presence of three external electromagnetic real potentials V(x), a potential barrier, a constant potential, and a potential well. By solving numerically the NLD equation, we find different scenarios depending on initial conditions, namely, propagation of the initial pulse along one direction, splitting of the initial pulse into two pulses traveling in opposite directions, and focusing of two initial pulses followed by a splitting...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345973/r-spondin-2-is-upregulated-in-idiopathic-pulmonary-fibrosis-and-affects-fibroblasts-behavior
#2
Adrián Munguía-Reyes, Yalbi I Balderas-Martínez, Carina Becerril, Marco Checa, Remedios Ramírez, Blanca Ortíz-Quintero, Jorge Meléndez-Zajgla, Annie Pardo, Moisés Selman
Idiopathic pulmonary fibrosis (IPF) is characterized by the expansion of the myofibroblasts population, excessive extracellular matrix accumulation, and destruction of the lung parenchyma. The R-spondins family (RSPO) comprises a group of proteins essential for development. From them, RSPO2 is expressed primarily in the lungs and its mutations cause severe defects in the respiratory tract. Interestingly, RSPO2 participates in the canonical WNT pathway, a critical route in the pathogenesis of IPF. Thus, the aim of this study was to examine the expression and putative role of RSPO2 in this disease...
January 18, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29343858/developmental-pathways-inferred-from-modularity-morphological-integration-and-fluctuating-asymmetry-patterns-in-the-human-face
#3
Mirsha Quinto-Sánchez, Francesc Muñoz-Muñoz, Jorge Gomez-Valdes, Celia Cintas, Pablo Navarro, Caio Cesar Silva de Cerqueira, Carolina Paschetta, Soledad de Azevedo, Virginia Ramallo, Victor Acuña-Alonzo, Kaustubh Adhikari, Macarena Fuentes-Guajardo, Tábita Hünemeier, Paola Everardo, Francisco de Avila, Claudia Jaramillo, Williams Arias, Carla Gallo, Giovani Poletti, Gabriel Bedoya, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Javier Rosique, Andres Ruiz-Linares, Rolando Gonzalez-Jose
Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331636/cell-wall-damage-and-oxidative-stress-in-candida-albicans-atcc10231-and-aspergillus-niger-caused-by-palladium-nanoparticles
#4
Martha Samira Athie-García, Hilda Amelia Piñón-Castillo, Laila Nayzzel Muñoz-Castellanos, Ana Laura Ulloa-Ogaz, Perla Ivonne Martínez-Varela, Armando Quintero-Ramos, Robert Duran, José Guadalupe Murillo-Ramirez, Erasmo Orrantia-Borunda
In this work the toxic effect of Palladium nanoparticles (PdNPs) was investigated in two eukaryotic cell models, Candida albicans and Aspergillus niger. PdNPs were synthesized by chemical reduction method, obtaining spherical NPs with a primary size ranging from 3 to 15 nm. PdNPs showed a hydrodynamic size of 1548 nm in Lee's minimum media. Minimal inhibitory concentration was determined at 200 and 250 ppm for Candida albicans and Aspergillus niger respectively, revealing a significant cell growth inhibition (ANOVA and tukey analysis, α = 0...
January 10, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29331267/identification-and-initial-optimization-of-inhibitors-of-clostridium-difficile-c-difficile-toxin-b-tcdb
#5
Jeffrey J Letourneau, Ilana L Stroke, David W Hilbert, Laurie J Sturzenbecker, Brett A Marinelli, Jorge G Quintero, Joan Sabalski, Linh Ma, David J Diller, Philip D Stein, Maria L Webb
The discovery, synthesis and preliminary structure-activity relationship (SAR) of a novel class of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB) is described. A high throughput screening (HTS) campaign resulted in the identification of moderately active screening hits 1-5 the most potent of which was compound 1 (IC50 = 0.77 µM). In silico docking of an early analog offered suggestions for structural modification which resulted in the design and synthesis of highly potent analogs 13j(IC50 = 1 nM) and 13 l(IC50 = 7 nM) which were chosen as leads for further optimization...
January 5, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29320800/risks-of-preterm-premature-rupture-of-membranes-and-preterm-birth-post-fetoscopy-based-on-location-of-trocar-insertion-site
#6
Ramen H Chmait, Andrew H Chon, Lisa M Korst, Arlyn Llanes, Eftichia V Kontopoulos, Ruben A Quintero
OBJECTIVE:  The objective of this study was to assess whether the location of the trocar insertion site for laser treatment of twin-twin transfusion syndrome was associated with preterm-premature rupture of membranes (PPROM) and preterm birth (PTB). STUDY DESIGN:  In this study trocar location was documented in the operating room. Lower uterine segment (LUS) location was defined as any insertion <10 cm vertically from the pubic symphysis. Lateral location was defined as ≥5 cm horizontally from the midline...
January 10, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29316200/formation-of-nanotubular-tio2-structures-with-varied-surface-characteristics-for-biomaterial-applications
#7
Robinson Aguirre, Mónica Echeverry-Rendón, David Quintero, Juan G Castaño, Martin C Harmsen, Sara Robledo, Félix Echeverría E
Nanotubular structures were generated on the surface of titanium c.p. by anodization technique in an aqueous solution of acetic acid (14% v/v) with different sources of fluoride ion (HF, NaF, NH4 F). The aim of using these three different compounds is to study the effect of the counterion (H+ , Na+ and NH4+ ) on the morphology, wettability and surface free energy of the modified surface. Nanotubes were generated at 10 and 15 V for each anodizing solution. To further improve surface characteristics, the samples were heat-treated at 600°C for 4 hours and at 560°C for 3 hours...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29315659/the-role-of-glutamate-signaling-in-incentive-salience-second-by-second-glutamate-recordings-in-awake-sprague-dawley-rats
#8
Seth R Batten, Francois Pomerleau, Jorge Quintero, Greg A Gerhardt, Joshua S Beckmann
The attribution of incentive salience to reward-predictive stimuli has been shown to be associated with substance abuse-like behavior such as increased drug taking. Evidence suggests that glutamate neurotransmission and sequential N-methyl-D-aspartate (NMDA) activation are involved in the attribution of incentive salience. Here we further explore the role of second-by-second glutamate neurotransmission in the attribution of incentive salience to reward-predictive stimuli by measuring sign-tracking behavior during a Pavlovian conditioned approach procedure using ceramic-based microelectrode arrays configured for sensitive measures of extracellular glutamate in awake behaving Sprague Dawley rats...
January 8, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29314321/percutaneous-fetoscopic-closure-of-large-open-spina-bifida-using-a-bilaminar-skin-substitute
#9
Denise A Lapa Pedreira, Gregório L Acacio, Rodrigo T Gonçalves, Renato Augusto M Sá, Reynaldo A Brandt, Ramen Chmait, Eftichia Kontopoulos, Ruben A Quintero
OBJECTIVE: We have previously described our percutaneous fetoscopic technique for the treatment of open spina bifida (OSB). However, approximately 20-30% of OSB defects are too large to allow primary skin closure. We hereby describe a modification of our standard technique using a bilaminar skin substitute to allow closure of such large spinal defects. The aim of this study was to report our clinical experience with the use of a bilaminar skin substitute and a percutaneous fetoscopic technique for the prenatal closure of large spina bifida defects...
January 4, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29295804/-primary-well-differentiated-neuroendocrine-tumor-of-the-filum-terminale-case-report-and-literature-review
#10
Juan Manuel Revuelta Barbero, Anwar Saab Mazzei, Carlos Cotúa Quinteros, Laura de Reina
OBJECTIVE: To present a case of a well-differentiated primary intradural-extramedullary neuroendocrine tumor of the filum terminale and to conduct a literature review. CASE: A 68-years old patient was assessed after presenting lower back pain and sciatica with ineffective pain relief. The patient presented an intradural-extramedullary lumbar lesion arising from the filum terminale, which was partially resected. The pathology diagnosis was a well-differentiated primary neuroendocrine tumor (carcinoid tumor)...
December 30, 2017: Neurocirugía
https://www.readbyqxmd.com/read/29291214/in-silico-design-and-molecular-docking-evaluation-of-peptides-derivatives-from-bacteriocins-and-porcine-beta-defensin-2-as-inhibitors-of-hepatitis-e-virus-capsid-protein
#11
Carolina Quintero-Gil, Jaime Parra-Suescún, Albeiro Lopez-Herrera, Sergio Orduz
Hepatitis E virus (HEV) is considered the main etiological agent that causes acute hepatitis. It is estimated that 20 million cases occur annually worldwide, reaching mortality rates of 28% in pregnant women. To date, available treatments and vaccines have not been entirely effective. In this study, six antiviral peptides derived from the sequences of porcine Beta-Defensin-2 and bacteriocins Nisin and Subtilosin were generate using in silico tools in order to propose new antiviral agents. Through the use of molecular docking, interactions between the HEV capsid protein and the six new antiviral peptide candidates were evaluated...
September 2017: Virusdisease
https://www.readbyqxmd.com/read/29289175/effects-of-transients-in-ligo-suspensions-on-searches-for-gravitational-waves
#12
M Walker, T D Abbott, S M Aston, G González, D M Macleod, J McIver, B P Abbott, R Abbott, C Adams, R X Adhikari, S B Anderson, A Ananyeva, S Appert, K Arai, S W Ballmer, D Barker, B Barr, L Barsotti, J Bartlett, I Bartos, J C Batch, A S Bell, J Betzwieser, G Billingsley, J Birch, S Biscans, C Biwer, C D Blair, R Bork, A F Brooks, G Ciani, F Clara, S T Countryman, M J Cowart, D C Coyne, A Cumming, L Cunningham, K Danzmann, C F Da Silva Costa, E J Daw, D DeBra, R T DeRosa, R DeSalvo, K L Dooley, S Doravari, J C Driggers, S E Dwyer, A Effler, T Etzel, M Evans, T M Evans, M Factourovich, H Fair, A Fernández Galiana, R P Fisher, P Fritschel, V V Frolov, P Fulda, M Fyffe, J A Giaime, K D Giardina, E Goetz, R Goetz, S Gras, C Gray, H Grote, K E Gushwa, E K Gustafson, R Gustafson, E D Hall, G Hammond, J Hanks, J Hanson, T Hardwick, G M Harry, M C Heintze, A W Heptonstall, J Hough, K Izumi, R Jones, S Kandhasamy, S Karki, M Kasprzack, S Kaufer, K Kawabe, N Kijbunchoo, E J King, P J King, J S Kissel, W Z Korth, G Kuehn, M Landry, B Lantz, N A Lockerbie, M Lormand, A P Lundgren, M MacInnis, S Márka, Z Márka, A S Markosyan, E Maros, I W Martin, D V Martynov, K Mason, T J Massinger, F Matichard, N Mavalvala, R McCarthy, D E McClelland, S McCormick, G McIntyre, G Mendell, E L Merilh, P M Meyers, J Miller, R Mittleman, G Moreno, G Mueller, A Mullavey, J Munch, L K Nuttall, J Oberling, M Oliver, P Oppermann, Richard J Oram, B O'Reilly, D J Ottaway, H Overmier, J R Palamos, H R Paris, W Parker, A Pele, S Penn, M Phelps, V Pierro, I Pinto, M Principe, L G Prokhorov, O Puncken, V Quetschke, E A Quintero, F J Raab, H Radkins, P Raffai, S Reid, D H Reitze, N A Robertson, J G Rollins, V J Roma, J H Romie, S Rowan, K Ryan, T Sadecki, E J Sanchez, V Sandberg, R L Savage, R M S Schofield, D Sellers, D A Shaddock, T J Shaffer, B Shapiro, P Shawhan, D H Shoemaker, D Sigg, B J J Slagmolen, B Smith, J R Smith, B Sorazu, A Staley, K A Strain, D B Tanner, R Taylor, M Thomas, P Thomas, K A Thorne, E Thrane, C I Torrie, G Traylor, D Tuyenbayev, G Vajente, G Valdes, A A van Veggel, A Vecchio, P J Veitch, K Venkateswara, T Vo, C Vorvick, R L Ward, J Warner, B Weaver, R Weiss, P Weßels, B Willke, C C Wipf, J Worden, G Wu, H Yamamoto, C C Yancey, Hang Yu, Haocun Yu, L Zhang, M E Zucker, J Zweizig
This paper presents an analysis of the transient behavior of the Advanced LIGO (Laser Interferometer Gravitational-wave Observatory) suspensions used to seismically isolate the optics. We have characterized the transients in the longitudinal motion of the quadruple suspensions during Advanced LIGO's first observing run. Propagation of transients between stages is consistent with modeled transfer functions, such that transient motion originating at the top of the suspension chain is significantly reduced in amplitude at the test mass...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29280649/waist-to-height-ratio-and-its-relation-with-cardiometabolic-risk-factors-in-children-from-bucaramanga-colombia
#13
Edna Magaly Gamboa Delgado, Clara Lucía Domínguez Urrego, Doris Cristina Quintero Lesmes
BACKGROUND: Currently, the waist-to-height ratio (WHtR) has emerged as a practical and useful indicator for identifying cardiometabolic risk in child and adolescent population. OBJECTIVE: To evaluate the association between the WHtR and cardiometabolic risk factors (CMRFs) in a cohort of children in Bucaramanga, Colombia. METHODS: Analytical cross-sectional study. Child population between 6-10 years old from Bucaramanga (n = 1,282). Dependent variables: hypertension, pre-hypertension, overweight/obesity, impaired glucose, insulin resistance and dyslipidemia...
November 16, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29258392/validation-of-a-patient-completed-caprini-risk-assessment-tool-for-spanish-arabic-and-polish-speakers
#14
Luis H Paz Rios, Harry E Fuentes, Diana M Oramas, Xavier A Andrade, Ahmed Al-Ogaili, Mina Iskander, Fady Iskander, Amir Nagui Abdalla Iskandar, Wictoria Kowacz, Adam Iwanski, Christine Acob, Luis Diaz Quintero, Juan Pablo Salazar-Adum, Alfonso Tafur, Joseph A Caprini
Targeted prophylaxis for venous thromboembolism (VTE) using the Caprini risk score (CRS) is effective reducing postoperative VTE. Despite its availability as preventive strategy, risk scoring remains underutilized. Critics to the CRS contend the time it takes to complete, and its limitation to English language. Aim is to create and validate patient-completed CRS tools for Spanish, Arabic, and Polish speakers. We translated the first patient-completed CRS to Spanish, Arabic, and Polish. We conducted a pilot study followed by the validation study...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29248723/iodine-prevents-the-increase-of-testosterone-induced-oxidative-stress-in-a-model-of-rat-prostatic-hyperplasia
#15
Michelle Quintero-García, Evangelina Delgado-González, Ana Sánchez-Tusie, Mario Vázquez, Carmen Aceves, Brenda Anguiano
Oxidative stress and inflammation are involved in the development and/or progression of benign prostatic hyperplasia (BPH). Molecular iodine (I2) induces antiproliferative and apoptotic effects in prostate cancer cells, but it is unknown if I2 regulates oxidative stress in the normal and/or tumoral prostate. The purpose of this study was to analyze the effects of I2 and celecoxib (Cxb) on oxidative stress and inflammation in a model of prostatic hyperplasia. Cxb was used as positive control of cyclooxygenase-2 (COX-2) inhibition...
December 14, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29248591/strategies-of-biochemical-adaptation-for-hibernation-in-a-south-american-marsupial-dromiciops-gliroides-3-activation-of-pro-survival-response-pathways
#16
Bryan E Luu, Sanoji Wijenayake, Jing Zhang, Shannon N Tessier, Julian F Quintero-Galvis, Juan Diego Gaitán-Espitia, Roberto F Nespolo, Kenneth B Storey
The South American marsupial, monito del monte (Dromiciops gliroides) uses both daily torpor and multi-day hibernation to survive in its southern Chile native environment. The present study leverages multiplex technology to assess the contributions of key stress-inducible cell cycle regulators and heat shock proteins to hibernation in liver, heart, and brain of monito del monte in a comparison of control versus 4day hibernating conditions. The data indicate that MDM2, a stress-responsive ubiquitin ligase, plays a crucial role in marsupial hibernation since all three tissues showed statistically significant increases in MDM2 levels during torpor (1...
December 14, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29247846/strategies-of-biochemical-adaptation-for-hibernation-in-a-south-american-marsupial-dromiciops-gliroides-2-control-of-the-akt-pathway-and-protein-translation-machinery
#17
Bryan E Luu, Sanoji Wijenayake, Jing Zhang, Shannon N Tessier, Julian F Quintero-Galvis, Juan Diego Gaitán-Espitia, Roberto F Nespolo, Kenneth B Storey
When faced with harsh environmental conditions, the South American marsupial, monito del monte (Dromiciops gliroides), reduces its body temperature and uses either daily torpor or multiday hibernation to survive. This study used ELISA and multiplex assays to characterize the responses to hibernation by three regulatory components of protein translation machinery [p-eIF2α(S51), p-eIF4E(S209), p-4EBP(Thr37/46)] and eight targets involved in upstream signaling control of translation [p-IGF-1R(Tyr1135/1136), PTEN(S380), p-Akt(S473), p-GSK-3α(S21), p-GSK-3β(S9), p-TSC2(S939), p-mTOR(S2448), and p70S6K(T412)]...
December 13, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29247845/strategies-of-biochemical-adaptation-for-hibernation-in-a-south-american-marsupial-dromiciops-gliroides-1-mitogen-activated-protein-kinases-and-the-cell-stress-response
#18
Sanoji Wijenayake, Bryan E Luu, Jing Zhang, Shannon N Tessier, Julian F Quintero-Galvis, Juan Diego Gaitán-Espitia, Roberto F Nespolo, Kenneth B Storey
Hibernation is a period of torpor and heterothermy that is typically associated with a strong reduction in metabolic rate, global suppression of transcription and translation, and upregulation of various genes/proteins that are central to the cellular stress response such as protein kinases, antioxidants, and heat shock proteins. The current study examined cell signaling cascades in hibernating monito del monte, Dromiciops gliroides, a South American marsupial of the Order Microbiotheria. Responses to hibernation by members of the mitogen-activated protein kinase (MAPK) pathways, and their roles in coordinating hibernator metabolism were examined in liver, kidney, heart and brain of control and versus hibernating (4days continuous torpor) D...
December 13, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29247844/strategies-of-biochemical-adaptation-for-hibernation-in-a-south-american-marsupial-dromiciops-gliroides-4-regulation-of-pyruvate-dehydrogenase-complex-and-metabolic-fuel-selection
#19
Sanoji Wijenayake, Bryan E Luu, Jing Zhang, Shannon N Tessier, Julian F Quintero-Galvis, Juan Diego Gaitán-Espitia, Roberto F Nespolo, Kenneth B Storey
Mammalian hibernation is characterized by extensive adjustments to metabolism that typically include suppression of carbohydrate catabolism and a switch to triglycerides as the primary fuel during torpor. A crucial locus of control in this process is the pyruvate dehydrogenase complex that gates carbohydrate entry into the tricarboxylic acid cycle. Within the complex, the E1 enzyme pyruvate dehydrogenase (PDH) is the main regulatory site and is subject to inhibitory phosphorylation at three serine residues (S232, S293, S300)...
December 13, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29247640/effects-of-a-novel-microtubule-depolymerizer-on-pro-inflammatory-signaling-in-raw264-7macrophages
#20
Samuel P Gilmore, Anna L K Gonye, Elizabeth C Li, Santiago Espinosa de Los Reyes, John T Gupton, Omar A Quintero, Krista Fischer-Stenger
The Nuclear Factor-kappa B (NF-κB) pathway is vital for immune system regulation and pro-inflammatory signaling. Many inflammatory disorders and diseases, including cancer, are linked to dysregulation of NF-κB signaling. When macrophages recognize the presence of a pathogen, the signaling pathway is activated, resulting in the nuclear translocation of the transcription factor, NF-κB, to turn on pro-inflammatory genes. Here, we demonstrate the effects of a novel microtubule depolymerizer, NT-07-16, a polysubstituted pyrrole compound, on this process...
December 13, 2017: Chemico-biological Interactions
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