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Mefenamic acid

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https://www.readbyqxmd.com/read/28211324/aqueous-chlorination-of-fenamic-acids-kinetic-study-transformation-products-identification-and-toxicity-prediction
#1
Liyun Ma, Jian Li, Li Xu
Fenamic acids, one important type of non-steroidal anti-inflammatory drugs, are ubiquitous in environmental matrices. Thus it is of high significance to know the fate of them during chlorination disinfection considering their potential toxicity to the environment and humans. In the present study, the chlorination kinetics of three fenamic acids, i.e. mefenamic acid (MEF), tolfenamic acid (TOL) and clofenamic acid (CLO), were examined at different pHs, which followed second-order reaction under studied conditions...
February 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28178610/removal-of-pharmaceuticals-from-municipal-wastewater-by-aerated-submerged-attached-growth-reactors
#2
Y Flores Velázquez, P Mijaylova Nacheva
The performance of four aerated submerged attached growth bioreactors was studied for the removal of three pharmaceutical micro-pollutants (fluoxetine, mefenamic acid and metoprolol) from municipal wastewater. Two packing materials (polyethylene tapes and polyurethane cubes) were compared and the effects of different organic loads (3.0, 6.0, 9.0 and 12 gCOD m(-2) d(-1)) and of the effluent recirculation were investigated. The obtained solid retention times were in the range of 4-37 d. The reactors packed with polyurethane cubes allowed 11-26% higher biomass accumulation than the ones with polyethylene tapes and higher solid retention times...
February 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28159976/screening-and-characterization-of-drugs-that-protect-corneal-endothelial-cells-against-unfolded-protein-response-and-oxidative-stress
#3
Eun Chul Kim, Tetsuya Toyono, Cynthia A Berlinicke, Donald J Zack, Ula Jurkunas, Tomohiko Usui, Albert S Jun
Purpose: To screen for and characterize compounds that protect corneal endothelial cells against unfolded protein response (UPR) and oxidative stress. Methods: Bovine corneal endothelial cells (BCECs) were treated for 48 hours with 640 compounds from a Food and Drug Administration (FDA)-approved drug library and then challenged with thapsigargin or H2O2 to induce UPR or oxidative stress, respectively. Cell viability was measured using the CellTiter-Glo survival assay...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28091995/biodegradability-of-fluoxetine-mefenamic-acid-and-metoprolol-using-different-microbial-consortiums
#4
Yolanda Flores Velázquez, Petia Mijaylova Nacheva
The biodegradation of fluoxetine, mefenamic acid, and metoprolol using ammonium-nitrite-oxidizing consortium, nitrite-oxidizing consortium, and heterotrophic biomass was evaluated in batch tests applying different retention times. The ammonium-nitrite-oxidizing consortium presented the highest biodegradation percentages for mefenamic acid and metoprolol, of 85 and 64% respectively. This consortium was also capable to biodegrade 79% of fluoxetine. The heterotrophic consortium showed the highest ability to biodegrade fluoxetine reaching 85%, and it also had a high potential for biodegrading mefenamic acid and metoprolol, of 66 and 58% respectively...
January 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28091717/bar-adsorptive-microextraction-technique-application-for-the-determination-of-pharmaceuticals-in-real-matrices
#5
Carlos Almeida, Samir M Ahmad, José Manuel F Nogueira
In the present work, bar adsorptive microextraction using miniaturized devices (7.5 × 3.0 mm) coated with suitable sorbent phases, combined with microliquid desorption (100 μL) followed by high-performance liquid chromatography with diode array detection (BAμE-μLD/HPLC-DAD), is proposed for the determination of trace level of six pharmaceuticals (furosemide, mebeverine, ketoprofen, naproxen, diclofenac and mefenamic acid) in environmental water and urine matrices. By comparing ten distinct sorbent materials (five polymeric and five activated carbons), the polymer P5 proved to be the most suitable to achieve the best selectivity and efficiency...
January 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28057544/mixed-micelle-system-produced-by-interaction-between-transglycosylated-stevia-and-an-ionic-surfactant-improves-dissolution-profile-of-mefenamic-acid
#6
Miki Fujimori, Kazunori Kadota, Yuichi Tozuka
Transglycosylated stevia (stevia-G) can effectively improve the dissolution and bioavailability of poorly water-soluble drugs. Furthermore, addition of an ionic surfactant to stevia-G solution has been shown to enhance the dissolution effect of stevia-G on flurbiprofen (FP). Herein, four surfactants, namely sodium dodecyl sulfate (SDS); sodium N-dodecanoylsarcosinate (SLAS); sodium monododecyl phosphate (SMP) and lauryltrimethylammonium chloride (LTAC) were screened to investigate their synergistic effect with stevia-G in enhancing the solubility of mefenamic acid (MFA)...
January 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28042403/comparison-of-the-effect-of-stretching-exercises-and-mefenamic-acid-on-the-reduction-of-pain-and-menstruation-characteristics-in-primary-dysmenorrhea-a-randomized-clinical-trial
#7
Narges Motahari-Tabari, Marjan Ahmad Shirvani, Abbas Alipour
OBJECTIVES: Dysmenorrhea is a common gynecologic disorder. Although non-steroidal anti-inflammatory drugs are commonly used, due to their side effects and lack of response in some individuals, other approaches such as exercise have been considered. This study compared the effect of stretching exercises and mefenamic acid on the reduction of pain and menstruation characteristics in primary dysmenorrhea. METHODS: In this randomized clinical trial, 122 female students with moderate to severe dysmenorrhea were assessed and were placed in either the exercise or mefenamic acid group...
January 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/27910834/solvates-of-selected-fenamic-acids-with-substituted-pyridines-structure-thermal-stability-and-desolvation
#8
Jacky S Bouanga Boudiombo, Ayesha Jacobs
Mefenamic acid (MA) formed solvates with 2-picoline (2PIC), 3-picoline (3PIC), 4-picoline (4PIC) and 3-chloropyridine (3CLPYR). The solvates crystallized in the space group P\bar 1 with the carboxylic acid of MA hydrogen-bonded to the nitrogen of the substituted pyridine. Tolfenamic acid (TFA) formed solvates with 2PIC and 3PIC, the crystal structures successfully solved in the space groups P21/n and Pbca, respectively. The fenamate conformation varied depending on the acid and the included solvent. Similarities were observed in the structures involving MA...
December 1, 2016: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/27884916/usual-medical-treatments-or-levonorgestrel-ius-for-women-with-heavy-menstrual-bleeding-long-term-randomised-pragmatic-trial-in-primary-care
#9
Joe Kai, Lee Middleton, Jane Daniels, Helen Pattison, Konstantinos Tryposkiadis, Janesh Gupta
BACKGROUND: Heavy menstrual bleeding (HMB) is a common, chronic problem affecting women and health services. However, long-term evidence on treatment in primary care is lacking. AIM: To assess the effectiveness of commencing the levonorgestrel-releasing intrauterine system (LNG-IUS) or usual medical treatments for women presenting with HMB in general practice. DESIGN AND SETTING: A pragmatic, multicentre, parallel, open-label, long term, randomised controlled trial in 63 primary care practices across the English Midlands...
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27884714/carrier-particle-design-for-stabilization-and-isolation-of-drug-nanoparticles
#10
Teresa Tierney, Katalin Bodnár, Åke Rasmuson, Sarah Hudson
Nanoparticles of poorly water-soluble drugs were prepared in suspension via antisolvent precipitation in order to improve their dissolution behaviour. Insoluble, surface-functionalized, micron-range, clay carrier particles were employed for the dual purpose of stabilizing the nanoparticles in suspended state, and facilitating their unhindered isolation to solid state; often a challenging step in nanoparticle production. The carrier particles, which were functionalized with an optimal level of cationic polymer (protamine), attracted negatively-charged nanoparticles to their surface as a uniform and segregated nanoparticle layer, at drug loadings up to 9% w/w...
November 21, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27785820/central-nervous-system-toxicity-of-mefenamic-acid-overdose-compared-with-other-nsaids-an-analysis-of-cases-reported-to-the-united-kingdom-national-poisons-information-service
#11
Ashraf Kamour, Siobhan Crichton, Gill Cooper, David J Lupton, Michael Eddleston, J Allister Vale, John P Thompson, Simon H L Thomas
AIMS: Case reports and small case series suggest increased central nervous system (CNS) toxicity, especially convulsions, after overdose of mefenamic acid, compared with other nonsteroidal anti-inflammatory drugs (NSAIDs), although comparative epidemiological studies have not been conducted. The current study compared rates of CNS toxicity after overdose between mefenamic acid, ibuprofen, diclofenac and naproxen, as reported in telephone enquiries to the UK National Poisons Information Service (NPIS)...
October 26, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27773318/ultrasound-assisted-crystallization-of-mefenamic-acid-effect-of-operating-parameters-and-comparison-with-conventional-approach
#12
Sneha R Iyer, Parag R Gogate
The current work investigates the application of low intensity ultrasonic irradiation for improving the cooling crystallization of Mefenamic Acid for the first time. The crystal shape and size has been analyzed with the help of optical microscope and image analysis software respectively. The effect of ultrasonic irradiation on crystal size, particle size distribution (PSD) and yield has been investigated, also establishing the comparison with conventional approach. It has been observed that application of ultrasound not only enhances the yield but also reduces the induction time for crystallization as compared to conventional cooling crystallization technique...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27752935/in-vitro-and-in-vivo-evaluation-of-casein-as-a-drug-carrier-for-enzymatically-triggered-dissolution-enhancement-from-solid-dispersions
#13
Ahmad Bani-Jaber, Iyad Alshawabkeh, Samaa Abdullah, Imad Hamdan, Adel Ardakani, Maha Habash
Due to its unique properties, such as biodegradability, biocompatibility, high amphiphilic property, and micelle formation, casein (CS) has been increasingly studied for drug delivery. We used CS as a drug carrier in solid dispersions (SDs) and evaluated the effect of its degradation by trypsin on drug dissolution from the dispersions. SDs of CS and mefenamic acid (MA) were prepared by physical mixing, kneading, and coprecipitation methods. In comparison to pure MA, the dispersions were evaluated for drug-protein interaction, loss of drug crystalinity, and drug morphology by differential scanning calorimetry, X-ray diffractometry, Fourier transform infrared spectroscopy, and scanning electron microscopy...
October 17, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27750166/mass-loading-and-removal-of-pharmaceuticals-and-personal-care-products-including-psychoactives-antihypertensives-and-antibiotics-in-two-sewage-treatment-plants-in-southern-india
#14
Bikram Subedi, Keshava Balakrishna, Derrick Ian Joshua, Kurunthachalam Kannan
Environmental contamination by pharmaceuticals and personal care products (PPCPs) is barely studied in India despite being one of the largest global producers and consumers of pharmaceuticals. In this study, 29 pharmaceuticals and six metabolites were determined in sewage treatment plants (STPs) in Udupi (STPU: population served ∼150,000) and Mangalore (STPM: population served ∼450,000); the measured mean concentrations ranged from 12 to 61,000 ng/L and 5.0 to 31,000 ng/L, respectively. Atorvastatin (the most prescribed antihypercholesterolemic in India), mefenamic acid, and paraxanthine were found for the first time in wastewater in India at the mean concentrations of 395 ng/L, 1100 ng/L, and 13,000 ng/L, respectively...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27681773/micellar-hplc-method-for-simultaneous-determination-of-ethamsylate-and-mefenamic-acid-in-presence-of-their-main-impurities-and-degradation-products
#15
Fawzia Ibrahim, Mohie K Sharaf El-Din, Asmaa Kamal El-Deen, Kuniyoshi Shimizu
An eco-friendly sensitive, rapid and less hazardous micellar liquid chromatographic method was developed and validated for the simultaneous analysis of ethamsylate (ETM) and mefenamic acid (MFA) in the presence of hydroquinone (HQ) and 2,3-dimethylaniline (DMA) the main impurities of ETM and MFA, respectively. Good chromatographic separation was attained using Eclipse XDB-C8 column (150 mm × 4.6 mm, 5 μm particle size) adopting UV detection at 300 nm with micellar mobile phase consisting of 0.12 M sodium dodecyl sulfate, 0...
January 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27614980/simultaneous-determination-of-12-pharmaceuticals-in-water-samples-by-ultrasound-assisted-dispersive-liquid-liquid-microextraction-coupled-with-ultra-high-performance-liquid-chromatography-with-tandem-mass-spectrometry
#16
Jin Guan, Chi Zhang, Yang Wang, Yiguang Guo, Peiting Huang, Longshan Zhao
A new analytical method was developed for simultaneous determination of 12 pharmaceuticals using ultrasound-assisted dispersive liquid-liquid microextraction (DLLME) followed by ultra-high performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS). Six nonsteroidal anti-inflammatory drugs (NSAIDs, ketoprofen, mefenamic acid, tolfenamic acid, naproxen, sulindac, and piroxicam) and six antibiotics (tinidazole, cefuroxime axetil, ciprofloxacin, sulfamethoxazole, sulfadiazine, and chloramphenicol) were extracted by ultrasound-assisted DLLME using dichloromethane (800 μL) and methanol/acetonitrile (1:1, v/v, 1200 μL) as the extraction and dispersive solvents, respectively...
November 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27602398/in-vitro-cytotoxic-effects-of-celecoxib-mefenamic-acid-aspirin-and-indometacin-on-several-cells-lines
#17
Maryam Alsadat Hashemipour, Hoda Mehrabizadeh Honarmand, Farideh Falsafi, Mehrnaz Tahmasebi Arashlo, Saied Rajabalian, Sayed Amir Hossein Gandjalikhan Nassab
STATEMENT OF THE PROBLEM: Use of cyclooxygenase inhibitors as chemotherapy agents has attracted the attention of a large number of investigators in recent years. Given the importance of cancer therapy, only a limited number of studies have been carried out to investigate the effects of cyclooxygenase inhibitors on specific cell lines. PURPOSE: This research aimed to determine the in vitro cytotoxic effects of cyclooxygenase inhibitors (COX-1 and COX-2 inhibitors) on KB, Saos-2, 1321N, U-87MG, SFBF-PI 39 cell lines...
September 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27591645/screening-determination-of-pharmaceutical-pollutants-in-different-water-matrices-using-dual-channel-capillary-electrophoresis-coupled-with-contactless-conductivity-detection
#18
Minh Duc Le, Hong Anh Duong, Manh Huy Nguyen, Jorge Sáiz, Hung Viet Pham, Thanh Duc Mai
In this study, the employment of purpose-made dual-channel compact capillary electrophoresis (CE) instrument with capacitively coupled contactless conductivity detection (C(4)D) as a simple and inexpensive solution for screening determination of various pharmaceutical pollutants frequently occurring in surface water and hospital wastewater in Hanoi, Vietnam is reported. Five negatively charged pharmaceutically active compounds, namely ibuprofen, diclofenac, bezafibrate, ketoprofen and mefenamic acid were determined using the first channel whereas three positively charged ones, namely diphenhydramine, metoprolol and atenolol were determined with the second channel of the CE-C(4)D instrument...
November 1, 2016: Talanta
https://www.readbyqxmd.com/read/27590546/simultaneous-extraction-of-acidic-and-basic-drugs-via-on-chip-electromembrane-extraction
#19
Yousef Abdossalami Asl, Yadollah Yamini, Shahram Seidi, Maryam Rezazadeh
In the present work, a on-chip electromembrane extraction (CEME) was designed and employed for simultaneous extraction of mefenamic acid (MEF) and diclofenac (DIC), as acidic model analytes, and betaxolol (BET), as a basic model analyte, followed by HPLC-UV. The CEME consists of two polymethyl methacrylate (PMMA) parts which each part consists of two separated microfluidic channels. A polypropylene sheet membrane impregnated with an organic solvent was sandwiched between the parts. One of the parts was used as the flow path for the sample solution and the other one as holder for the acceptor phases...
September 21, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27578463/nonsteroidal-anti-inflammatory-drug-nsaid-exacerbated-respiratory-disease-phenotype-topical-nsaid-and-asthma-control-a-possible-oversight-link
#20
Jessica Han Ying Tan, Anne Ann Ling Hsu
BACKGROUND: Patients with aspirin-exacerbated respiratory disease (AERD) also recently known as nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease (NERD) must avoid aspirin and all other oral NSAIDs. The effect of topical NSAID (tNSAID), especially salicylates which are commonly present in topical medicated preparations, on asthma control of this phenotype is studied. METHODS: The study inclusion criteria were adults with: 1) NSAID hypersensitivity; 2) nasal polyposis/chronic rhinosinusitis; 3) not well-/poorly controlled asthma and 4) exposure to tNSAID...
September 2016: Respiratory Medicine
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