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Mefenamic acid

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https://www.readbyqxmd.com/read/28623433/comparison-of-the-effect-of-honey-and-mefenamic-acid-on-the-severity-of-pain-in-women-with-primary-dysmenorrhea
#1
Ë Leila Amiri Farahani, Seyedeh Batool Hasanpoor-Azghdy, Hengameh Kasraei, Tooba Heidari
BACKGROUND AND OBJECTIVE: Primary dysmenorrhea starts simultaneously with menstruation or before it and usually continues for 48-72 h. As a prevalence disorder, it affects about 80-97% of women in the reproductive age. The conventional treatment modalities of primary dysmenorrhea are associated with complications and side effects. In addition, there is a lack of knowledge of the effect of honey on the treatment of primary dysmenorrhea. The objective of this study is to investigate the effect of honey on the severity of pain in women with dysmenorrhea...
June 16, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28586618/non-steroidal-anti-inflammatory-drugs-vs-paracetamol-drug-availability-patients-preference-and-knowledge-of-toxicity
#2
Quratulain Zamir, Amina Nadeem
OBJECTIVE: Self-medication is a common practice which is influenced by level of education, society factors and health care facilities availability. In our region, Pakistan, it is very common and awareness regarding prescription implementation needs to be ensured. Hence the current study highlights the preference, availability and knowledge of toxicity of non-steroidal antiinflammatory medications and paracetamol in Pakistan. METHODS: It was a Descriptive, cross sectional, conducted in Rawalpindi and Islamabad, Pakistan from May to august 2012...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28509850/accessing-mefenamic-acid-form-ii-through-high-pressure-recrystallisation
#3
Nasir Abbas, Iain D H Oswald, Colin R Pulham
High-pressure crystallisation has been successfully used as an alternative technique to prepare Form II of a non-steroidal anti-inflammatory drug, mefenamic acid (MA). A single crystal of Form II, denoted as high-pressure Form II, was grown at 0.3 GPa from an ethanolic solution by using a diamond anvil cell. A comparison of the crystal structures shows that the efficient packing of molecules in Form II was enabled by the structural flexibility of MA molecules. Compression studies performed on a single crystal of Form I resulted in a 14% decrease of unit cell volume up to 2...
May 16, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28498911/different-chromatographic-methods-for-simultaneous-determination-of-mefenamic-acid-and-two-of-its-toxic-impurities
#4
Martha M Morcoss, Nada S Abdelwahab, Nouruddin W Ali, Mohammed T Elsaady
Two sensitive, accurate and precise chromatographic methods mentioned as TLC-densitometric method and RP-HPLC-DAD method, were developed and validated for the simultaneous determination of mefenamic acid (MEF) and its two toxic impurities, benzoic acid (BA) and 2,3-dimethylaniline (DMA). In the proposed TLC-densitometric method a developing system consisting of chloroform:acetone:acetic acid:ammonia solution(70:30:2:2, v/v/v/v) was used, TLC aluminum plates 60 F254 was used as a stationary phase and the separated bands were UV-scanned at 225 nm...
May 11, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28485428/exploring-micropollutant-biotransformation-in-three-freshwater-phytoplankton-species
#5
Michael A Stravs, Francesco Pomati, Juliane Hollender
Phytoplankton constitute an important component of surface water ecosystems; however little is known about their contribution to biotransformation of organic micropollutants. To elucidate biotransformation processes, batch experiments with two cyanobacterial species (Microcystis aeruginosa and Synechococcus sp.) and one green algal species (Chlamydomonas reinhardtii) were conducted. Twenty-four micropollutants were studied, including 15 fungicides and 9 pharmaceuticals. Online solid phase extraction (SPE) coupled with liquid chromatography (LC)-high resolution tandem mass spectrometry (HRMS/MS) was used together with suspect and nontarget screening to identify transformation products (TPs)...
June 21, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28401228/environmental-photochemistry-of-fenamate-nsaids-and-their-radical-intermediates
#6
Caroline A Davis, Paul R Erickson, Kristopher McNeill, Elisabeth M L Janssen
Fenamates are a class of nonsteroidal anti-inflammatory drugs (NSAIDs) that are not fully removed during wastewater treatment and can be released to surface waters. Here, near-surface photochemical half-lives were evaluated to range from minutes to hours of four fenamates and the closely related diclofenac. While quantum yields for direct photochemical reactions at the water surface vary widely from 0.071 for diclofenac to <0.001 for mefenamic acid, all fenamates showed significant reactivity towards singlet oxygen and hydroxyl radical with bimolecular reaction rate constants of 1...
May 24, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28398095/influence-of-drug-load-on-dissolution-behavior-of-tablets-containing-a-poorly-water-soluble-drug-estimation-of-the-percolation-threshold
#7
Tim Wenzel, Cordula Stillhart, Peter Kleinebudde, Anikó Szepes
Drug load plays an important role in the development of solid dosage forms, since it can significantly influence both processability and final product properties. The percolation threshold of the active pharmaceutical ingredient (API) corresponds to a critical concentration, above which an abrupt change in drug product characteristics can occur. The objective of this study was to identify the percolation threshold of a poorly water-soluble drug with regard to the dissolution behavior from immediate release tablets...
April 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28370591/mefenamic-acid-decreases-inflammation-but-not-joint-lesions-in-experimental-osteoarthritis
#8
Grazielle C Aguiar, Celso M Queiroz-Junior, Giovana L Sitta, Flávio A Amaral, Mauro M Teixeira, Marcelo V Caliari, Anderson J Ferreira
Mefenamic acid is a non-steroidal anti-inflammatory drug able to control the symptoms of osteoarthritis (OA), but its effects on protection of cartilage and bone are still unclear. This study aimed to investigate whether the control of inflammation by mefenamic acid translates into decreased joint lesions in experimental OA in rats. OA was induced by injecting 1 mg of monosodium iodoacetate (MIA) into the joints of rats. The animals were treated with mefenamic acid (50 mg/kg, daily, oral gavage) either pre-MIA injection (preventive) or post-MIA injection (therapeutic)...
December 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28291611/degradation-kinetics-of-pharmaceuticals-and-personal-care-products-in-surface-waters-photolysis-vs-biodegradation
#9
Rosa María Baena-Nogueras, Eduardo González-Mazo, Pablo A Lara-Martín
Poor removal of many pharmaceuticals and personal care products (PPCPs) in sewage treatment leads to their discharge into the receiving waters, where they may cause negative effects. Their elimination from the water column depends of several processes, including photochemical and biological degradation. We have focused this research on comparing the degradation kinetics of a wide number (n=33) of frequently detected PPCPs considering different types of water, pH and solar irradiation. For those compounds that were susceptible of photodegradation, their rates (k) varied from 0...
March 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28287743/a-systematic-study-of-molecular-interactions-of-anionic-drugs-with-a-dimethylaminoethyl-methacrylate-copolymer-regarding-solubility-enhancement
#10
Wiebke Saal, Alfred Ross, Nicole Wyttenbach, Jochem Alsenz, Martin Kuentz
The methacrylate-copolymer Eudragit EPO (EPO) has raised interest in solubility enhancement of anionic drugs. Effects on aqueous drug solubility at rather low polymer concentrations are barely known despite their importance upon dissolution and dilution of oral dosage forms. We provide evidence for substantial enhancement (factor 4-230) of aqueous solubility of poorly water-soluble anionic drugs induced by low (0.1-5% (w/w)) concentration of EPO for a panel of seven acidic crystalline drugs. Diffusion data (determined by (1)H nuclear magnetic resonance spectroscopy) indicate that the solubility increasing effect monitored by quantitative ultraperformance liquid chromatography was caused primarily by molecular API polymer interactions in the bulk liquid phase...
April 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28262313/high-performance-liquid-chromatography-mass-spectrometry-analysis-of-the-parent-drugs-and-their-metabolites-in-extracts-from-cress-lepidium-sativum-grown-hydroponically-in-water-containing-four-non-steroidal-anti-inflammatory-drugs
#11
Lisa Emhofer, Markus Himmelsbach, Wolfgang Buchberger, Christian W Klampfl
In this paper the metabolism of four non-steroidal anti-inflammatory drugs, (ketoprofen, mefenamic acid, naproxen, and diclofenac) by cress (Lepidium sativum) is described. Cress was cultivated hydroponically in water spiked with the parent drugs at levels ranging from 0.01mgL(-1) to 1mgL(-1). Employing an approach based on the analysis of the plant extracts by HPLC coupled either with quadrupole-time-of-flight mass spectrometry, or Orbitrap MS or triple quadrupole (QqQ) MS allowed the identification of twenty substances (sixteen metabolites and four parent drugs)...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28259989/mefenamic-acid-enhances-anticancer-drug-sensitivity-via-inhibition-of-aldo-keto-reductase-1c-enzyme-activity
#12
Masashi Shiiba, Hitomi Yamagami, Ayumi Yamamoto, Yasuyuki Minakawa, Atsushi Okamoto, Atsushi Kasamatsu, Yosuke Sakamoto, Katsuhiro Uzawa, Yuichi Takiguchi, Hideki Tanzawa
Resistance to anticancer medications often leads to poor outcomes. The present study explored an effective approach for enhancing chemotherapy targeted against human cancer cells. Real-time quantitative real-time polymerase chain reaction (qRT-PCR) analysis revealed overexpression of members of aldo-keto reductase (AKR) 1C family, AKR1C1, AKR1C2, AKR1C3, and AKR1C4, in cisplatin, cis-diamminedichloroplatinum (II) (CDDP)-resistant human cancer cell lines, HeLa (cervical cancer cells) and Sa3 (oral squamous cell carcinoma cells)...
April 2017: Oncology Reports
https://www.readbyqxmd.com/read/28259712/molecular-docking-synthesis-and-biological-screening-of-mefenamic-acid-derivatives-as-anti-inflammatory-agents
#13
Jignasa K Savjani, Suja Mulamkattil, Bhavesh Variya, Snehal Patel
Drug induced gastrointestinal ulceration, renal side effects and hepatotoxicity are the main causes of numerous Non-Steroidal Anti-inflammatory Drugs (NSAIDs). Cyclooxygenase-2 (COX-2) inhibitors discovered to decrease the gastrointestinal issues, but unfortunately, most of them are associated with major cardiovascular adverse effects. Along these lines, various new strategies and frameworks were developed wherein basic alterations of the present medications were accounted for. The aim of the study was to prepare derivatives of mefenamic acid to evaluate anti-inflammatory activity with fewer adverse reactions...
April 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28213245/one-pot-synthesis-of-gold-carbon-dots-nanocomposite-and-its-application-for-cytosensing-of-metals-for-cancer-cells
#14
Hani Nasser Abdelhamid, Abuo Talib, Hui-Fen Wu
Cytosensing of biological transition metals is paramount important for cancer research. One-pot synthesis of the nanocomposite of carbon dots (CDs) and gold nanoparticles (AuNPs) is reported and has been applied for metal cytosensing. The nanocomposite (GCDs) is synthesized using citric acid (CA) and L-cysteine as precursors in the presence of chloroauric acid. The synthesis procedure exhibits many advantages including simple one step, green approach (solvent free method) and requires cheap chemical precursors...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28211324/aqueous-chlorination-of-fenamic-acids-kinetic-study-transformation-products-identification-and-toxicity-prediction
#15
Liyun Ma, Jian Li, Li Xu
Fenamic acids, one important type of non-steroidal anti-inflammatory drugs, are ubiquitous in environmental matrices. Thus it is of high significance to know the fate of them during chlorination disinfection considering their potential toxicity to the environment and humans. In the present study, the chlorination kinetics of three fenamic acids, i.e. mefenamic acid (MEF), tolfenamic acid (TOL) and clofenamic acid (CLO), were examined at different pHs, which followed second-order reaction under studied conditions...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28178610/removal-of-pharmaceuticals-from-municipal-wastewater-by-aerated-submerged-attached-growth-reactors
#16
Y Flores Velázquez, P Mijaylova Nacheva
The performance of four aerated submerged attached growth bioreactors was studied for the removal of three pharmaceutical micro-pollutants (fluoxetine, mefenamic acid and metoprolol) from municipal wastewater. Two packing materials (polyethylene tapes and polyurethane cubes) were compared and the effects of different organic loads (3.0, 6.0, 9.0 and 12 gCOD m(-2) d(-1)) and of the effluent recirculation were investigated. The obtained solid retention times were in the range of 4-37 d. The reactors packed with polyurethane cubes allowed 11-26% higher biomass accumulation than the ones with polyethylene tapes and higher solid retention times...
May 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28159976/screening-and-characterization-of-drugs-that-protect-corneal-endothelial-cells-against-unfolded-protein-response-and-oxidative-stress
#17
Eun Chul Kim, Tetsuya Toyono, Cynthia A Berlinicke, Donald J Zack, Ula Jurkunas, Tomohiko Usui, Albert S Jun
Purpose: To screen for and characterize compounds that protect corneal endothelial cells against unfolded protein response (UPR) and oxidative stress. Methods: Bovine corneal endothelial cells (BCECs) were treated for 48 hours with 640 compounds from a Food and Drug Administration (FDA)-approved drug library and then challenged with thapsigargin or H2O2 to induce UPR or oxidative stress, respectively. Cell viability was measured using the CellTiter-Glo survival assay...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28091995/biodegradability-of-fluoxetine-mefenamic-acid-and-metoprolol-using-different-microbial-consortiums
#18
Yolanda Flores Velázquez, Petia Mijaylova Nacheva
The biodegradation of fluoxetine, mefenamic acid, and metoprolol using ammonium-nitrite-oxidizing consortium, nitrite-oxidizing consortium, and heterotrophic biomass was evaluated in batch tests applying different retention times. The ammonium-nitrite-oxidizing consortium presented the highest biodegradation percentages for mefenamic acid and metoprolol, of 85 and 64% respectively. This consortium was also capable to biodegrade 79% of fluoxetine. The heterotrophic consortium showed the highest ability to biodegrade fluoxetine reaching 85%, and it also had a high potential for biodegrading mefenamic acid and metoprolol, of 66 and 58% respectively...
March 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28091717/bar-adsorptive-microextraction-technique-application-for-the-determination-of-pharmaceuticals-in-real-matrices
#19
Carlos Almeida, Samir M Ahmad, José Manuel F Nogueira
In the present work, bar adsorptive microextraction using miniaturized devices (7.5 × 3.0 mm) coated with suitable sorbent phases, combined with microliquid desorption (100 μL) followed by high-performance liquid chromatography with diode array detection (BAμE-μLD/HPLC-DAD), is proposed for the determination of trace level of six pharmaceuticals (furosemide, mebeverine, ketoprofen, naproxen, diclofenac and mefenamic acid) in environmental water and urine matrices. By comparing ten distinct sorbent materials (five polymeric and five activated carbons), the polymer P5 proved to be the most suitable to achieve the best selectivity and efficiency...
January 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28057544/mixed-micelle-system-produced-by-interaction-between-transglycosylated-stevia-and-an-ionic-surfactant-improves-dissolution-profile-of-mefenamic-acid
#20
Miki Fujimori, Kazunori Kadota, Yuichi Tozuka
Transglycosylated stevia (stevia-G) can effectively improve the dissolution and bioavailability of poorly water-soluble drugs. Furthermore, addition of an ionic surfactant to stevia-G solution has been shown to enhance the dissolution effect of stevia-G on flurbiprofen. Herein, 4 surfactants, namely sodium dodecyl sulfate, sodium N-dodecanoylsarcosinate, sodium monododecyl phosphate, and lauryltrimethylammonium chloride (LTAC) were screened to investigate their synergistic effect with stevia-G in enhancing the solubility of mefenamic acid (MFA)...
January 3, 2017: Journal of Pharmaceutical Sciences
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