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Mefenamic acid

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https://www.readbyqxmd.com/read/27910834/solvates-of-selected-fenamic-acids-with-substituted-pyridines-structure-thermal-stability-and-desolvation
#1
Jacky S Bouanga Boudiombo, Ayesha Jacobs
Mefenamic acid (MA) formed solvates with 2-picoline (2PIC), 3-picoline (3PIC), 4-picoline (4PIC) and 3-chloropyridine (3CLPYR). The solvates crystallized in the space group P\bar 1 with the carboxylic acid of MA hydrogen-bonded to the nitrogen of the substituted pyridine. Tolfenamic acid (TFA) formed solvates with 2PIC and 3PIC, the crystal structures successfully solved in the space groups P21/n and Pbca, respectively. The fenamate conformation varied depending on the acid and the included solvent. Similarities were observed in the structures involving MA...
December 1, 2016: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/27884916/usual-medical-treatments-or-levonorgestrel-ius-for-women-with-heavy-menstrual-bleeding-long-term-randomised-pragmatic-trial-in-primary-care
#2
Joe Kai, Lee Middleton, Jane Daniels, Helen Pattison, Konstantinos Tryposkiadis, Janesh Gupta
BACKGROUND: Heavy menstrual bleeding (HMB) is a common, chronic problem affecting women and health services. However, long-term evidence on treatment in primary care is lacking. AIM: To assess the effectiveness of commencing the levonorgestrel-releasing intrauterine system (LNG-IUS) or usual medical treatments for women presenting with HMB in general practice. DESIGN AND SETTING: A pragmatic, multicentre, parallel, open-label, long term, randomised controlled trial in 63 primary care practices across the English Midlands...
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27884714/carrier-particle-design-for-stabilization-and-isolation-of-drug-nanoparticles
#3
Teresa Tierney, Katalin Bodnár, Åke Rasmuson, Sarah Hudson
Nanoparticles of poorly water-soluble drugs were prepared in suspension via antisolvent precipitation in order to improve their dissolution behaviour. Insoluble, surface-functionalized, micron-range, clay carrier particles were employed for the dual purpose of stabilizing the nanoparticles in suspended state, and facilitating their unhindered isolation to solid state; often a challenging step in nanoparticle production. The carrier particles, which were functionalized with an optimal level of cationic polymer (protamine), attracted negatively-charged nanoparticles to their surface as a uniform and segregated nanoparticle layer, at drug loadings up to 9% w/w...
November 21, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27785820/central-nervous-system-toxicity-of-mefenamic-acid-overdose-compared-to-other-nsaids-an-analysis-of-cases-reported-to-the-united-kingdom-national-poisons-information-service
#4
A Kamour, S Crichton, G Cooper, D J Lupton, M Eddleston, J A Vale, J P Thompson, S H L Thomas
AIMS: Case reports and small case series suggest increased Central Nervous System (CNS) toxicity especially convulsions, after overdose of mefenamic acid, compared with other NSAIDs, but comparative epidemiological studies have not been conducted. This study compared rates of CNS toxicity after overdose between mefenamic acid, ibuprofen, diclofenac and naproxen, as reported in telephone enquiries to the United Kingdom National Poisons Information Service (NPIS). METHODS: NPIS telephone enquiries related to the four NSAIDs received between January 2007 and December 2013 were analysed, comparing the frequency of reported CNS toxicity (convulsions, altered conscious level, agitation or aggression, confusion or disorientation) using multivariable logistic regression...
October 26, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27773318/ultrasound-assisted-crystallization-of-mefenamic-acid-effect-of-operating-parameters-and-comparison-with-conventional-approach
#5
Sneha R Iyer, Parag R Gogate
The current work investigates the application of low intensity ultrasonic irradiation for improving the cooling crystallization of Mefenamic Acid for the first time. The crystal shape and size has been analyzed with the help of optical microscope and image analysis software respectively. The effect of ultrasonic irradiation on crystal size, particle size distribution (PSD) and yield has been investigated, also establishing the comparison with conventional approach. It has been observed that application of ultrasound not only enhances the yield but also reduces the induction time for crystallization as compared to conventional cooling crystallization technique...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27752935/in-vitro-and-in-vivo-evaluation-of-casein-as-a-drug-carrier-for-enzymatically-triggered-dissolution-enhancement-from-solid-dispersions
#6
Ahmad Bani-Jaber, Iyad Alshawabkeh, Samaa Abdullah, Imad Hamdan, Adel Ardakani, Maha Habash
Due to its unique properties, such as biodegradability, biocompatibility, high amphiphilic property, and micelle formation, casein (CS) has been increasingly studied for drug delivery. We used CS as a drug carrier in solid dispersions (SDs) and evaluated the effect of its degradation by trypsin on drug dissolution from the dispersions. SDs of CS and mefenamic acid (MA) were prepared by physical mixing, kneading, and coprecipitation methods. In comparison to pure MA, the dispersions were evaluated for drug-protein interaction, loss of drug crystalinity, and drug morphology by differential scanning calorimetry, X-ray diffractometry, Fourier transform infrared spectroscopy, and scanning electron microscopy...
October 17, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27750166/mass-loading-and-removal-of-pharmaceuticals-and-personal-care-products-including-psychoactives-antihypertensives-and-antibiotics-in-two-sewage-treatment-plants-in-southern-india
#7
Bikram Subedi, Keshava Balakrishna, Derrick Ian Joshua, Kurunthachalam Kannan
Environmental contamination by pharmaceuticals and personal care products (PPCPs) is barely studied in India despite being one of the largest global producers and consumers of pharmaceuticals. In this study, 29 pharmaceuticals and six metabolites were determined in sewage treatment plants (STPs) in Udupi (STPU: population served ∼150,000) and Mangalore (STPM: population served ∼450,000); the measured mean concentrations ranged from 12 to 61,000 ng/L and 5.0 to 31,000 ng/L, respectively. Atorvastatin (the most prescribed antihypercholesterolemic in India), mefenamic acid, and paraxanthine were found for the first time in wastewater in India at the mean concentrations of 395 ng/L, 1100 ng/L, and 13,000 ng/L, respectively...
October 14, 2016: Chemosphere
https://www.readbyqxmd.com/read/27681773/micellar-hplc-method-for-simultaneous-determination-of-ethamsylate-and-mefenamic-acid-in-presence-of-their-main-impurities-and-degradation-products
#8
Fawzia Ibrahim, Mohie K Sharaf El-Din, Asmaa Kamal El-Deen, Kuniyoshi Shimizu
An eco-friendly sensitive, rapid and less hazardous micellar liquid chromatographic method was developed and validated for the simultaneous analysis of ethamsylate (ETM) and mefenamic acid (MFA) in the presence of hydroquinone (HQ) and 2,3-dimethylaniline (DMA) the main impurities of ETM and MFA, respectively. Good chromatographic separation was attained using Eclipse XDB-C8 column (150 mm × 4.6 mm, 5 μm particle size) adopting UV detection at 300 nm with micellar mobile phase consisting of 0.12 M sodium dodecyl sulfate, 0...
September 27, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27614980/simultaneous-determination-of-12-pharmaceuticals-in-water-samples-by-ultrasound-assisted-dispersive-liquid-liquid-microextraction-coupled-with-ultra-high-performance-liquid-chromatography-with-tandem-mass-spectrometry
#9
Jin Guan, Chi Zhang, Yang Wang, Yiguang Guo, Peiting Huang, Longshan Zhao
A new analytical method was developed for simultaneous determination of 12 pharmaceuticals using ultrasound-assisted dispersive liquid-liquid microextraction (DLLME) followed by ultra-high performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS). Six nonsteroidal anti-inflammatory drugs (NSAIDs, ketoprofen, mefenamic acid, tolfenamic acid, naproxen, sulindac, and piroxicam) and six antibiotics (tinidazole, cefuroxime axetil, ciprofloxacin, sulfamethoxazole, sulfadiazine, and chloramphenicol) were extracted by ultrasound-assisted DLLME using dichloromethane (800 μL) and methanol/acetonitrile (1:1, v/v, 1200 μL) as the extraction and dispersive solvents, respectively...
November 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27602398/in-vitro-cytotoxic-effects-of-celecoxib-mefenamic-acid-aspirin-and-indometacin-on-several-cells-lines
#10
Maryam Alsadat Hashemipour, Hoda Mehrabizadeh Honarmand, Farideh Falsafi, Mehrnaz Tahmasebi Arashlo, Saied Rajabalian, Sayed Amir Hossein Gandjalikhan Nassab
STATEMENT OF THE PROBLEM: Use of cyclooxygenase inhibitors as chemotherapy agents has attracted the attention of a large number of investigators in recent years. Given the importance of cancer therapy, only a limited number of studies have been carried out to investigate the effects of cyclooxygenase inhibitors on specific cell lines. PURPOSE: This research aimed to determine the in vitro cytotoxic effects of cyclooxygenase inhibitors (COX-1 and COX-2 inhibitors) on KB, Saos-2, 1321N, U-87MG, SFBF-PI 39 cell lines...
September 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27591645/screening-determination-of-pharmaceutical-pollutants-in-different-water-matrices-using-dual-channel-capillary-electrophoresis-coupled-with-contactless-conductivity-detection
#11
Minh Duc Le, Hong Anh Duong, Manh Huy Nguyen, Jorge Sáiz, Hung Viet Pham, Thanh Duc Mai
In this study, the employment of purpose-made dual-channel compact capillary electrophoresis (CE) instrument with capacitively coupled contactless conductivity detection (C(4)D) as a simple and inexpensive solution for screening determination of various pharmaceutical pollutants frequently occurring in surface water and hospital wastewater in Hanoi, Vietnam is reported. Five negatively charged pharmaceutically active compounds, namely ibuprofen, diclofenac, bezafibrate, ketoprofen and mefenamic acid were determined using the first channel whereas three positively charged ones, namely diphenhydramine, metoprolol and atenolol were determined with the second channel of the CE-C(4)D instrument...
November 1, 2016: Talanta
https://www.readbyqxmd.com/read/27590546/simultaneous-extraction-of-acidic-and-basic-drugs-via-on-chip-electromembrane-extraction
#12
Yousef Abdossalami Asl, Yadollah Yamini, Shahram Seidi, Maryam Rezazadeh
In the present work, a on-chip electromembrane extraction (CEME) was designed and employed for simultaneous extraction of mefenamic acid (MEF) and diclofenac (DIC), as acidic model analytes, and betaxolol (BET), as a basic model analyte, followed by HPLC-UV. The CEME consists of two polymethyl methacrylate (PMMA) parts which each part consists of two separated microfluidic channels. A polypropylene sheet membrane impregnated with an organic solvent was sandwiched between the parts. One of the parts was used as the flow path for the sample solution and the other one as holder for the acceptor phases...
September 21, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27578463/nonsteroidal-anti-inflammatory-drug-nsaid-exacerbated-respiratory-disease-phenotype-topical-nsaid-and-asthma-control-a-possible-oversight-link
#13
Jessica Han Ying Tan, Anne Ann Ling Hsu
BACKGROUND: Patients with aspirin-exacerbated respiratory disease (AERD) also recently known as nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease (NERD) must avoid aspirin and all other oral NSAIDs. The effect of topical NSAID (tNSAID), especially salicylates which are commonly present in topical medicated preparations, on asthma control of this phenotype is studied. METHODS: The study inclusion criteria were adults with: 1) NSAID hypersensitivity; 2) nasal polyposis/chronic rhinosinusitis; 3) not well-/poorly controlled asthma and 4) exposure to tNSAID...
September 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27563318/evaluation-of-mint-efficacy-regarding-dysmenorrhea-in-comparison-with-mefenamic-acid-a-double-blinded-randomized-crossover-study
#14
Seyedeh Zahra Masoumi, Horieh Rezvani Asl, Jalal Poorolajal, Mohammad Hosseini Panah, Seyedeh Reyhaneh Oliaei
BACKGROUND: Menthol is the most important active material in mint and different mechanisms have been suggested for the way mint functions, most of which emphasize its analgesic effect owing to the presence of a group of temporary protein receptors. This study investigates the efficacy of peppermint capsule in the treatment of primary dysmenorrhea, in comparison with Mefenamic Acid and placebo. MATERIALS AND METHODS: This was a prospective, double-blinded, crossover study and was conducted on 127 girl students studying in Hamadan University of Medical Sciences who had experienced primary dysmenorrhea...
July 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/27556594/reflection-of-socioeconomic-changes-in-wastewater-licit-and-illicit-drug-use-patterns
#15
Nikolaos S Thomaidis, Pablo Gago-Ferrero, Christoph Ort, Niki C Maragou, Nikiforos A Alygizakis, Viola L Borova, Marilena E Dasenaki
The economic crisis plaguing Greece was expected to impact consumption of pharmaceuticals and illicit drugs - a priori to an unknown extent. We quantified the change of use for various classes of licit and illicit drugs by monitoring Athens' wastewater from 2010 to 2014. A high increase in the use of psychoactive drugs was detected between 2010 and 2014, especially for antipsychotics (35-fold), benzodiazepines (19-fold), and antidepressants (11-fold). This directly reflects the perceived increase of incidences associated with mental illnesses in the population, as a consequence of severe socioeconomic changes...
September 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27509875/fenamate-nsaids-inhibit-the-nlrp3-inflammasome-and-protect-against-alzheimer-s-disease-in-rodent-models
#16
Michael J D Daniels, Jack Rivers-Auty, Tom Schilling, Nicholas G Spencer, William Watremez, Victoria Fasolino, Sophie J Booth, Claire S White, Alex G Baldwin, Sally Freeman, Raymond Wong, Clare Latta, Shi Yu, Joshua Jackson, Nicolas Fischer, Violette Koziel, Thierry Pillot, James Bagnall, Stuart M Allan, Pawel Paszek, James Galea, Michael K Harte, Claudia Eder, Catherine B Lawrence, David Brough
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in many inflammatory diseases. Here we show that several clinically approved and widely used NSAIDs of the fenamate class are effective and selective inhibitors of the NLRP3 inflammasome via inhibition of the volume-regulated anion channel in macrophages, independently of COX enzymes...
2016: Nature Communications
https://www.readbyqxmd.com/read/27495788/sunitinib-ddi-with-paracetamol-diclofenac-mefenamic-acid-and-ibuprofen-shows-sex-divergent-effects-on-the-tissue-uptake-and-distribution-pattern-of-sunitinib-in-mice
#17
Siok Yean Tan, Mei Mei Wong, Angela Lu Wun Tiew, Yai Wen Choo, Suat Hun Lim, Ing Hong Ooi, Pilar Modamio, Cecilia Fernández, Eduardo L Mariño, Ignacio Segarra
PURPOSE: Pharmacokinetic interaction of sunitinib with diclofenac, paracetamol, mefenamic acid and ibuprofen was evaluated due to their P450 mediated metabolism and OATP1B1, OATP1B3, ABCB1, ABCG2 transporters overlapping features. METHODS: Male and female mice were administered 6 sunitinib doses (60 mg/kg) PO every 12 h and 30 min before the last dose were administered vehicle (control groups), 250 mg/kg paracetamol, 30 mg/kg diclofenac, 50 mg/kg mefenamic acid or 30 mg/kg ibuprofen (study groups), euthanized 6 h post last administration and sunitinib plasma, liver, kidney, brain concentrations analyzed...
October 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27494650/formulation-and-evaluation-of-novel-controlled-release-of-topical-pluronic-lecithin-organogel-of-mefenamic-acid
#18
Vikas Jhawat, Sumeet Gupta, Vipin Saini
In the present study, pluronic lecithin based organogels (PLO gels) were formulated as topical carrier for controlled delivery of mefenamic acid. Ten organogel formulations were prepared by a method employing lecithin as lipophilic phase and pluronic F-127 as hydrophilic phase in varying concentrations to study various parameters using in vitro diffusion study and in vivo studies. All formulations were found to be off-white, homogenous, and reluctant to be washed easily and have pH value within the range of 5...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27468710/use-of-non-selective-non-steroidal-anti-inflammatory-drugs-in-relation-to-cardiovascular-events-a-systematic-pharmacoepidemiological-review
#19
Christos Kontogiorgis, Ioannis Valikeserlis, Dimitra Hadjipavlou-Litina, Evangelia Nena, Theodoros C Constantinidis
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used, having numerous indications. However, despite their therapeutic role, they are associated with serious cardiovascular (CV) adverse events. Objectives-Methods: This review comprising recent observational studies and meta-analyses over the past few years aims at updating the assessment of CV adverse events, namely stroke, myocardial infarction (MI), CV death, atrial fibrillation (AF), serious bleeding and heart failure related to the use of 4 of the most widely prescribed NSAIDs: ibuprofen, naproxen, diclofenac and mefenamic acid...
July 27, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27443568/menstrual-loss-of-renal-function-a-case-of-mefenamic-acid-induced-renal-cortical-necrosis
#20
Terry King-Wing Ma, Jack Kit-Chung Ng, Bonnie Ching-Ha Kwan, Cheuk Chun Szeto, Philip Kam-Tao Li
No abstract text is available yet for this article.
September 2016: Clinical Nephrology
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