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https://www.readbyqxmd.com/read/28721513/does-pyuria-always-suggest-urinary-tract-infection-with-common-microorganisms-questions
#1
Mehmet Taşdemir, Hüseyin Kaya, Zeynep Atam Taşdemir
Genitourinary system tuberculosis (GUTB) is a chronic granulomatous infection in which tuberculous bacilli affect one or more organs in the genitourinary system. In this report, an unusual presentation of miliary tuberculosis was presented as GUTB. A 15-year-old girl presented with complaints of severe abdominal pain and dysuria. Abdominal examination showed tenderness and defense. Pyuria and microscopic hematuria were observed. Acute abdominal causes could not be excluded through abdominal ultrasound. On abdominal computed tomography, a necrotic lesion was detected in the right kidney...
July 18, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28715978/the-role-of-efflux-pumps-in-tuberculosis-treatment-and-their-promise-as-a-target-in-drug-development-unraveling-the-black-box
#2
Lindsey H M Te Brake, Gerjo J de Knegt, Jurriaan E de Steenwinkel, Teunis J P van Dam, David M Burger, Frans G M Russel, Reinout van Crevel, Jan B Koenderink, Rob E Aarnoutse
Insight into drug transport mechanisms is highly relevant to the efficacious treatment of tuberculosis (TB). Major problems in TB treatment are related to the transport of antituberculosis (anti-TB) drugs across human and mycobacterial membranes, affecting the concentrations of these drugs systemically and locally. Firstly, transporters located in the intestines, liver, and kidneys all determine the pharmacokinetics and pharmacodynamics of anti-TB drugs, with a high risk of drug-drug interactions in the setting of concurrent use of antimycobacterial, antiretroviral, and antidiabetic agents...
July 17, 2017: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28714235/tuberculosis-after-kidney-transplantation-is-associated-with-significantly-impaired-allograft-function
#3
Silvana Daher Costa, Tainá Veras de Sandes-Freitas, Camilla Neves Jacinto, Lorena Vasconcelos Mesquita Martiniano, Yago Sucupira Amaral, Fernando José Villar Nogueira Paes, Maria Luiza de Mattos Brito Oliveira Sales, Ronaldo de Matos Esmeraldo, Elizabeth de Francesco Daher
BACKGROUND: This study aimed to evaluate renal function before, during and after the course of tuberculosis (TB) disease in kidney transplant recipients; and assess the risk factors for non-recovery of baseline renal function. METHODS: We performed a retrospective, single-center cohort study, including all patients with confirmed or presumed TB diagnosis after kidney transplant (n=34, 2.1%). Renal function was assessed by serum creatinine (Cr) and glomerular filtration rate (GFR) adjusted for deaths and graft losses...
July 17, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28698838/tuberculosis-in-kidney-transplant-recipients-a-case-series
#4
Manish Anand, Ekta Nayyar, Beatrice Concepcion, Megha Salani, Heidi Schaefer
Solid organ transplant recipients have an elevated risk of tuberculosis (TB) with high mortality. Data about TB in this population in the United States is sparse. We present four cases of active tuberculosis in kidney transplant recipients at our center. All patients had possible TB exposure prior to transplant and all were diagnosed with active TB within the first year of transplant. Disseminated TB was seen in half of the patients with extra-pulmonary TB being more common affecting lymph nodes, pericardium, and the kidney allograft...
June 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28697838/-hypertension-and-intermittent-convulsions-for-one-month-in-a-school-age-child
#5
Mao-Qiang Tian, Shu-Yi Liu, Juan Li, Xiao-Mei Shu
Childhood polyarteritis nodosa (PAN) is a rare systemic vasculitis and the delayed diagnosis and treatment will cause high incidence of sequelae and high mortality. This article reports a girl with childhood PAN due to posterior reversible encephalopathy syndrome (PRES). The girl aged ten years was admitted to the hospital due to hypertension and convulsions for one month. She had complaints of headache, vomiting, and blurred vision before convulsions. At six months before admission, a mass was observed in the neck...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28655852/role-of-east-6-in-renal-injury-by-regulating-microrna-155-expression-via-tlr4-myd88-signaling-pathway-in-mice-with-mycobacterium-tuberculosis-infection
#6
Zhong-Qi Zhou, Zhi-Kui Wang, Lei Zhang, Yue-Qin Ren, Zhong-Wei Ma, Nan Zhao, Fu-Yun Sun
The study aims to investigate the underlying mechanism involved with the early secretory antigenic target-6 (ESAT-6) in renal injury through regulation of the expression of microRNA-155 (miR-155) through the TLR4/MyD88 signaling pathway in Mycobacterium tuberculosis ( MTB )-infected mice. Sixty C57BL/6 mice with MTB-induced renal injury were randomly assigned into control, MTB, mimic, inhibitor and inhibitor + ESAT6 and inhibitor + ESAT6 + TAK242 groups. Body weight, the ratio of kidney weight to body weight (Kw/Bw), blood urea nitrogen (BUN) and serum creatinine (Scr) of mice were measured...
June 27, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28652112/multinational-retrospective-case-control-study-of-risk-factors-for-the-development-of-late-invasive-pulmonary-aspergillosis-following-kidney-transplantation
#7
Francisco López-Medrano, Mario Fernández-Ruiz, José Tiago Silva, Peggy L Carver, Christian van Delden, Esperanza Merino, María José Pérez-Saez, Milagros Montero, Julien Coussement, Milene de Abreu Mazzolin, Carlos Cervera, Lidia Santos, Nuria Sabé, Anne Scemla, Elisa Cordero, Leónidas Cruzado-Vega, Paloma Leticia Martín-Moreno, Óscar Len, Eddison Rudas, Alfredo Ponce de León, Mariano Arriola, Ricardo Lauzurica, Miruna D David, Claudia González-Rico, Fernando Henríquez-Palop, Jesús Fortún, Marcio Nucci, Oriol Manuel, José Ramón Paño-Pardo, Miguel Montejo, Antonio Vena, Beatriz Sánchez-Sobrino, Auxiliadora Mazuecos, Julio Pascual, Juan Pablo Horcajada, Thanh Lecompte, Asunción Moreno, Jordi Carratalà, Marino Blanes, Domingo Hernández, Erick Alejandro Hernández-Méndez, María Carmen Fariñas, Manuel Perelló-Carrascosa, Patricia Muñoz, Amado Andrés, José María Aguado
OBJECTIVES: To assess the risk factors for the development of late-onset invasive pulmonary aspergillosis (IPA) after kidney transplantation (KT). METHODS: We performed a multinational case-control study that retrospectively recruited 112 KT recipients diagnosed with IPA between 2000 and 2013. Controls were matched (1:1 ratio) by center and date of transplantation. Immunosuppression-related events (IREs) included the occurrence of non-ventilator-associated pneumonia, tuberculosis, cytomegalovirus disease and/or de novo malignancy...
June 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28629354/acetone-leaf-extracts-of-some-south-african-trees-with-high-activity-against-escherichia-coli-also-have-good-antimycobacterial-activity-and-selectivity-index
#8
Ishaku L Elisha, Francien S Botha, Balungile Madikizela, Lyndy J McGaw, Jacobus N Eloff
BACKGROUND: Tuberculosis is a world-wide problem affecting humans and animals. There is increasing development of resistance of the pathogens to current antimycobacterial agents. Many authors have investigated activities of extracts and isolated compounds from plants. The traditional uses of plants have frequently been the criterion to select plants investigated. In this contribution, we investigate whether plant extracts with very good activity against Escherichia coli may also be active against mycobacteria...
June 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28627673/release-characteristics-of-bone%C3%A2-like-hydroxyapatite-poly-amino-acid-loaded-with-rifapentine-microspheres-in%C3%A2-vivo
#9
Yuwu Liu, Jiming Zhu, Dianming Jiang
Bone-like hydroxyapatite/poly amino acid (BHA/PAA) is a potential bone repair material. Rifapentine-loaded poly(lactic‑co‑glycolic acid) microspheres (RPMs) are bioactive and efficient controlled‑release delivery systems used in vitro. The aim of the present study was to investigate the in vivo drug release characteristics of RPM‑loaded BHA/PAA on a rabbit model of bone defect. RPM was combined with BHA/PAA to obtain the drug‑loaded, slow‑releasing bioactive material. Bone defects were generated in New Zealand white rabbits and the rabbits were then implanted with RPM‑loaded BHA/PAA...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28591968/-risk-factors-for-mortality-among-patients-with-sepsis-complicated-with-active-tuberculosis
#10
Yang-Ting Li, Xue-Lian Liao, Li Han, Yan Kang
OBJECTIVES: To determine risk factors associated with mortality of patients with sepsis complicated with active tuberculosis (TB) in intensive care units (ICU). METHODS: We reviewed medical records of 61 TB patients whom were admitted to the ICU in West China Hospital of Sichuan University, among whom 19 were dead. Logistic regression models were established to determine predictors of mortality. RESULTS: The acute physiology and chronic health evaluation (APACHE Ⅱ) score, smear-positive sputum, delayed treatment of active TB and acute kidney dysfunction were independent predictors of mortality...
July 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28583573/kidney-transplantation-in-korean-patients-with-end-stage-renal-disease-aged-65-and-older-a-single-center-experience
#11
S S Kang, W Y Park, K Jin, S B Park, S Han
BACKGROUND: The mean age of patients starting dialysis in Korea has increased to older than 60 years and the proportion of patients aged 65 and older exceeded 40% in 2014. Although the number of elderly dialysis patients is increasing rapidly, percentages of elderly patients undergoing kidney transplantation (KT) are very low. METHODS: We retrospectively reviewed the medical records of patients who underwent KT at Keimyung University Dongsan Medical Center between 1982 and 2016...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28579016/executive-summary-of-the-gesida-national-aids-plan-consensus-document-on-antiretroviral-therapy-in-adults-infected-by-the-human-immunodeficiency-virus-updated-january-2017
#12
(no author information available yet)
Antiretroviral therapy (ART) is recommended for all patients infected by HIV-1. The objective of ART is to achieve an undetectable plasma viral load (PVL). Initial ART should be based on a combination of 3 drugs, including 2 nucleoside reverse transcriptase inhibitors (tenofovir in either of its two formulations plus emtricitabine or abacavir plus lamivudine) and another drug from a different family. Four of the recommended regimens, all of which have an integrase inhibitor as the third drug (dolutegravir, elvitegravir boosted with cobicistat or raltegravir), are considered preferential, whereas a further 3 regimens (based on elvitegravir/cobicistat, rilpivirine, or darunavir boosted with cobicistat or ritonavir) are considered alternatives...
May 31, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28577928/renal-tuberculosis-following-intravesical-bcg-for-high-grade-non-muscle-invasive-bladder-cancer
#13
Neha Sihra, Nonaka Diasuke, Ramesh Thurairaja, Muhammad Shamim Khan, Sachin Malde
A 47-year-old man presented to the urology department with visible haematuria. He was found to have a high-grade non-muscle-invasive transitional cell carcinoma of the bladder and was subsequently treated with intravesical BCG instillations. On routine surveillance CT scan following treatment he was found to have multiple rounded areas of low density in the right kidney, suspicious for renal malignancy. He underwent renal biopsy which revealed necrotising granulomatous inflammation suggestive of mycobacterial infection...
May 31, 2017: Urology
https://www.readbyqxmd.com/read/28526681/adoptive-transfer-of-phosphoantigen-specific-%C3%AE-%C3%AE-t-cell-subset-attenuates-mycobacterium-tuberculosis-infection-in-nonhuman-primates
#14
Arwa Qaqish, Dan Huang, Crystal Y Chen, Zhuoran Zhang, Richard Wang, Shengpu Li, Enzhuoa Yang, Yang Lu, Michelle H Larsen, William R Jacobs, Lixia Qian, James Frencher, Ling Shen, Zheng W Chen
The dominant Vγ2Vδ2 T cell subset recognizes phosphoantigen and exists only in humans and nonhuman primates. Despite the discovery of γδ T cells >30 y ago, a proof-of-concept study has not been done to prove the principle that the Vγ2Vδ2 T cell subset is protective against Mycobacterium tuberculosis and other infections. In this study, we used an adoptive cell-transfer strategy to define the protective role of Vγ2Vδ2 T cells in a primate tuberculosis (TB) model. Vγ2Vδ2 T cells for adoptive transfer displayed central/effector memory and mounted effector functions, including the production of anti-M...
June 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28512022/synthesis-antimycobacterial-activity-and-docking-study-of-2-aroyl-1-benzopyrano-4-3-c-pyrazol-4-1h-one-derivatives-and-related-hydrazide-hydrazones
#15
Violina T Angelova, Violeta Valcheva, Tania Pencheva, Yulian Voynikov, Nikolay Vassilev, Rositsa Mihaylova, Georgi Momekov, Boris Shivachev
A new convenient method for preparation of 2-aroyl-[1]benzopyrano[4,3-c]pyrazol-4(1H)-one derivatives 5b-g and coumarin containing hydrazide-hydrazone analogues 4a-e was presented. The antimycobacterial activity against reference strain Mycobacterium tuberculosis H37Rv and cytotoxicity against the human embryonic kidney cell line HEK-293 were tested in vitro. All compounds demonstrated significant minimum inhibitory concentrations (MIC) ranging 0.28-1.69μM, which were comparable to those of isoniazid. The cytotoxicity (IC50>200µM) to the "normal cell" model HEK-293T exhibited by 2-aroyl-[1]benzopyrano[4,3-c]pyrazol-4(1H)-one derivatives 5b-e, was noticeably milder compared to that of their hydrazone analogues 4a-e (IC50 33-403µM)...
May 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28488732/involvement-of-the-warburg-effect-in-non-tumor-diseases-processes
#16
REVIEW
Zhe Chen, Meiqing Liu, Lanfang Li, Linxi Chen
Warburg effect, as an energy shift from mitochondrial oxidative phosphorylation to aerobic glycolysis, is extensively found in various cancers. Interestingly, increasing researchers show that Warburg effect plays a crucial role in non-tumor diseases. For instance, inhibition of Warburg effect can alleviate pulmonary vascular remodeling in the process of pulmonary hypertension. Interference of Warburg effect improves mitochondrial function and cardiac function in the process of cardiac hypertrophy and heart failure...
May 10, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28487118/pittosporum-viridiflorum-sims-pittosporaceae-a-review-on-a-useful-medicinal-plant-native-to-south-africa-and-tropical-africa
#17
REVIEW
B Madikizela, L J McGaw
ETHNOPHARMACOLOGICAL RELEVANCE: Pittosporum viridiflorum Sims, a Pittosporaceae species, is used extensively in African traditional medicine (ATM) by various tribes. This review is an appraisal of the information concerning the description, distribution, conservation status, traditional uses, phytochemistry, pharmacology and toxicology of this species with the aim of reconciling it with its traditional use. MATERIALS AND METHODS: A wide-ranging literature search was conducted using database platforms such as Scopus, Google Scholar, Web of Science, ScienceDirect, PubMed and books including local reports and thesis submissions...
May 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28462170/renal-tuberculosis-in-a-9-months-old-case-report-and-review-of-the-literature
#18
Ariadna Fabià Mayans, Oriol Angerri Feu, Helena Ascaso Til, Yolanda Arce Terroba, Rebeca Blanco Fernández, Anna Bujons Tur, Jorge Caffaratti Sfulcini
A nine months old girl with prenatal diagnosis of bilateral hydronephrosis underwent serious studies and in view of the presumed diagnosis of right functional annulment, a right laparoscopic nephroureterectomy was performed. The anatomopatological result was suggestive of tuberculosis without previous contact with the disease. Postoperatively, the child received antituberculosis therapy (ATT) for a full 8 months (isoniazid, rifampin, pyrazinamide and ethambutol for 2 months and isoniazid and rifampin for 6 months) and the follow-up tests revealed improvement of ureterohydronephrosis in left kidney...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28438256/clinical-profile-and-outcome-of-patients-with-biopsy-proven-acute-interstitial-nephritis-in-cape-town-a-10-year-review%C3%A2
#19
Emmanuel E Effa, Udeme E Ekrikpo, Megan Borkum, Brian L Rayner, Peter Heering, Ikechi G Okpechi
BACKGROUND: Acute interstitial nephritis (AIN) is a common cause of acute kidney injury that has not been adequately characterized in Sub-Saharan Africa (SSA) despite an increasing use of potentially inciting agents for the treatment of human immunodeficiency virus (HIV) and tuberculosis in the region. METHODS: A retrospective audit of records of patients with biopsy-proven AIN diagnosed at Groote Schuur Hospital, Cape Town from the 1st of January, 2006, to the 31st of December, 2015...
April 25, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28423031/comorbidities-of-rheumatoid-arthritis-results-from-the-korean-national-health-and-nutrition-examination-survey
#20
Hyemin Jeong, Sun Young Baek, Seon Woo Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha
This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South Korea using interviews and basic health assessment, was analyzed retrospectively. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed in patients with RA compared with the non-RA population. The overall weighted (n = 37,453,158) prevalence of RA was 1...
2017: PloS One
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