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aspirin pancreas

Maja Dimitrovska, Mirsada Dervisevik, Natasa Cipanovska, Katerina Gerazova, Suzana Dinevska-Kjovkarovska, Biljana Miova
Heat preconditioning (HP) is a powerful adaptive and protective phenomenon and the heat stress proteins (HSPs) it produces are an important determinant for the development of diabetic complications. Aspirin has been reported to modulate heat shock response in different organisms through increased induction of HSPs and is also known to exert antioxidative and radical scavenging effects in diabetes. We estimated the effect of physiological (heat stress: 45 min at 41 ± 0.5 °C) and pharmacological (aspirin treatment) induction of HSP70 on several parameters of oxidative state in the pancreas and liver of diabetic rats...
February 2018: Canadian Journal of Physiology and Pharmacology
Lisa E Vaughan, Anna Prizment, Cindy K Blair, William Thomas, Kristin E Anderson
PURPOSE: Few studies have evaluated the chemopreventive effect of aspirin on the cancer risk in elderly women. We examined associations between frequency, dose, and duration of aspirin use with incidence of 719 aspirin-sensitive cancers (cancers of colon, pancreas, breast, and ovaries) in the Iowa Women's Health Study (IWHS), a prospective cohort of women over 70 years old. METHODS: Aspirin frequency, dose, and duration were self-reported in the 2004 IWHS questionnaire...
November 2016: Cancer Causes & Control: CCC
Thea Veitonmäki, Teemu J Murtola, Kirsi Talala, Kimmo Taari, Teuvo Tammela, Anssi Auvinen
Non-steroidal anti-inflammatory drugs (NSAIDs), especially aspirin, have been associated with lowered cancer incidence and mortality. We examined overall cancer mortality and mortality from specific cancer sites among the 80,144 men in the Finnish Prostate Cancer Screening Trial. Information on prescription drug use was acquired from the national drug reimbursement database. Over-the-counter use information was gathered by a questionnaire. Hazard ratios (HR) and 95% confidence intervals (CI) by prescription and over-the-counter NSAID use for overall and specific cancer deaths were calculated using Cox regression...
2016: PloS One
Thomas W Kensler, Avrum Spira, Judy E Garber, Eva Szabo, J Jack Lee, Zigang Dong, Andrew J Dannenberg, William N Hait, Elizabeth Blackburn, Nancy E Davidson, Margaret Foti, Scott M Lippman
We have entered a transformative period in cancer prevention (including early detection). Remarkable progress in precision medicine and immune-oncology, driven by extraordinary recent advances in genome-wide sequencing, big-data analytics, blood-based technologies, and deep understanding of the tumor immune microenvironment (TME), has provided unprecedented possibilities to study the biology of premalignancy. The pace of research and discovery in precision medicine and immunoprevention has been astonishing and includes the following clinical firsts reported in 2015: driver mutations detected in circulating cell-free DNA in patients with premalignant lesions (lung); clonal hematopoiesis shown to be a premalignant state; molecular selection in chemoprevention randomized controlled trial (RCT; oral); striking efficacy in RCT of combination chemoprevention targeting signaling pathway alterations mechanistically linked to germline mutation (duodenum); molecular markers for early detection validated for lung cancer and showing promise for pancreatic, liver, and ovarian cancer...
January 2016: Cancer Prevention Research
Fajing Yang, Jianming Xie, Weiming Wang, Yangyun Xie, Hongwei Sun, Yuepeng Jin, Dan Xu, Bicheng Chen, Roland Andersson, Mengtao Zhou
OBJECTIVE: Investigate the therapeutic effect of regional arterial infusion (RAI) with Aspirin-Triggered Lipoxin A4 (ATL) in experimental severe acute pancreatitis (SAP) in rats. MATERIALS AND METHODS: SAP was induced by injection of 5% sodium taurocholate into the pancreatic duct. Rats with SAP were treated with ATL (the ATL group) or physiological saline (the SAP group) infused via the left gastric artery 30 min after injection of sodium taurocholate. The sham group was subjected to the same surgical procedure, though without induction of SAP...
2014: PloS One
Samantha A Streicher, Herbert Yu, Lingeng Lu, Mark S Kidd, Harvey A Risch
BACKGROUND: Pancreas-cancer prognosis is dismal, with 5-year survival less than 5%. Significant relationships between aspirin use and decreased pancreas-cancer incidence and mortality have been shown in four of 13 studies. METHODS: To evaluate further a possible association between aspirin use and risk of pancreatic cancer, we used data from a population-based Connecticut study conducted from January 2005 to August 2009, of 362 pancreas-cancer cases frequency matched to 690 randomly sampled controls...
July 2014: Cancer Epidemiology, Biomarkers & Prevention
M N Sela, M Lahav, N Ne'eman, Z Duchan, I Ginsburg
Lysis of(14)C-labeledStaph. aureus by human blood leukocyte lysates, by extracts of rabbit small intestines and pancreas, and by the "cocktail" of enzymes (containing trypsin, lysolecithin, and lysozyme) is strongly inhibited by anionic polyelectrolytes (e.g., heparin, chondroitin sulfate, liquoid (polyanethole sulfonic acid), and DNA). Most of the lytic agents employed were inhibited by cationic polyelectrolytes (e.g., histone, protamin sulfate and polylysin), as well as by gold thiomalate, normal human serum, synovial fluids obtained from patients with knee-joint trauma, extracts of coffee, tea, and cocoa, Ultracorten- and Dexamethasone...
March 1975: Inflammation
Ibrahim Akyazi, Evren Eraslan, Ahmet Gülçubuk, Elif Ergül Ekiz, Zeynep L Cırakli, Damla Haktanir, Deniz Aktaran Bala, Mete Ozkurt, Erdal Matur, Mukaddes Ozcan
AIM: To investigate the effects of long term pretreatment with low-, medium- and high-dose aspirin (acetylsalicylic acid, ASA) on a model of acute pancreatitis (AP) induced in rats. METHODS: Forty male Wistar rats were used. Three experimental groups, each consisting of eight animals, received low- (5 mg/kg per day), medium- (150 mg/kg per day) and high-dose (350 mg/kg per day) ASA in supplemented pellet chow for 100 d. Eight animals, serving as the AP-control group, and another eight, serving as reference value (RV) group, were fed with standard pellet chow for the same period...
May 21, 2013: World Journal of Gastroenterology: WJG
H Yıldız, H Oztas, D Yıldız, A Koc, E Kalipci
We investigated short (6 months) and long (12 months) term inhibitory effects of low (200 ppm) and high (400 ppm) dosages of acetylsalicylic acid (aspirin) on exocrine pancreatic carcinogenesis. It is known that exocrine pancreatic carcinogenesis can be detected by the presence of atypical acinar cell foci (AACF) in pancreas. We investigated possible inhibitory effects of acetylsalicylic acid in an azaserine-treated rat model. AACF were produced in rats by injection with azaserine according to previous studies...
May 2013: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Chinthalapally V Rao, Altaf Mohammed, Naveena B Janakiram, Qian Li, Rebekah L Ritchie, Stan Lightfoot, Awasthi Vibhudutta, Vernon E Steele
Nitric oxide-releasing aspirin (NO-aspirin) represents a novel class of promising chemopreventive agents. Unlike conventional nonsteroidal anti-inflammatory drugs, NO-aspirin seems to be free of adverse effects while retaining the beneficial activities of its parent compound. The effect of NO-aspirin on pancreatic carcinogenesis was investigated by assessing the development of precursor pancreatic lesions and adenocarcinomas in Kras(G12D/+) transgenic mice that recapitulate human pancreatic cancer progression...
September 2012: Neoplasia: An International Journal for Oncology Research
Dimo Dimov, Kamen Kanev, Ivanka Dimova
Butyrylcholinesterase (BChE) is synthesized in the liver and found in high concentrations in blood plasma, liver, heart, pancreas, vascular endothelium, skin, brain white matter, smooth muscle cells and adipocytes. BChE is a non specific enzyme that hydrolyzes different choline esters (succinylcholine, mivacurium) and many other drugs such as aspirin, cocaine and procaine. The enzyme is also considered as a bioscavenger due to its ability to neutralize the toxic effects of organophosphorus compounds (nervous system fs agents) such as soman...
2012: Acta Biochimica Polonica
Li Gao, Jennie L Williams
NO-aspirin (NO-ASA), consisting of aspirin and a nitric oxide-releasing group, is safer than aspirin and effective in colon cancer prevention. Here, we examined the mechanism of action of NO-ASA by focusing primarily on its effects on the cell cycle. NO-ASA reduced the growth of several cell lines from colon, pancreas, skin, cervix and breast cancer much more potently than aspirin, with 24-h IC(50) values of 133-268 µM, while those of ASA were >1,000 µM. NO-ASA elevated the intracellular levels of reactive oxygen species, generating a state of oxidative stress...
July 2012: International Journal of Oncology
C Bosetti, V Rosato, S Gallus, J Cuzick, C La Vecchia
BACKGROUND: Aspirin has been associated to a reduced risk of colorectal and possibly of a few other common cancers. METHODS: To provide an up-to-date quantification of this association, we conducted a meta-analysis of all observational studies on aspirin and 12 selected cancer sites published up to September 2011. RESULTS: Regular aspirin is associated with a statistically significant reduced risk of colorectal cancer [summary relative risk (RR) from random effects models = 0...
June 2012: Annals of Oncology: Official Journal of the European Society for Medical Oncology
José Lariño Noia
Pancreatic cancer (PC) continues to have a poor prognosis. New epidemiological trials have suggested that there may be protective factors, such as aspirin or oleic acid intake. The main diagnostic tool for PC is endoscopic ultrasound (EUS), and new EUS-related technologies have appeared, such as quantitative elastography (strain ratio and hue histogram analysis), intravenous contrasts, and the new procore needles to help in the differential diagnosis with other diseases (mainly chronic pancreatitis). In the next few years, intratumoral confocal endomicroscopy will be used for the diagnosis of PC and cystic tumors, by inserting a miniprobe inside the 19G needle of the echoendoscope...
October 2011: Gastroenterología y Hepatología
Alan C Farney, Jeffrey Rogers, Robert J Stratta
PURPOSE OF REVIEW: Pancreas graft thrombosis remains one of the most common reasons for pancreas transplant loss. Patients with a history of thrombotic events should be identified and evaluated for thrombophilia to identify transplant candidates at highest risk. RECENT FINDINGS: Early after transplant, vascular thrombosis is multifactorial, but beyond 2 weeks, inflammation or acute rejection predominate as the cause of thrombosis. Most pancreas transplant centers utilize some form of anticoagulation following transplantation...
February 2012: Current Opinion in Organ Transplantation
W A Nasif, M Lotfy, M R Mahmoud
OBJECTIVES: The current study was carried out to examine the influence of aspirin (400 mg/kg of body weight) and gum acacia (one g/day) and their combination on pancreatic, intestinal mucosal enzymes, intestinal tissue iron and zinc after 21 days of treatment on experimental rats. MATERIALS AND METHODS: The treated rats were sacrificed and the pancreatic and intestinal lipase and amylase were measured photometrically. Moreover, zinc and iron level were determined using atomic absorption spectrometry...
March 2011: European Review for Medical and Pharmacological Sciences
Thomas D Atwell, Ryan L Smith, Gina K Hesley, Matthew R Callstrom, Cathy D Schleck, W Scott Harmsen, J William Charboneau, Timothy J Welch
OBJECTIVE: The objective of our study was to report the incidence of bleeding after imaging-guided percutaneous core biopsy at a single center using a standardized technique. MATERIALS AND METHODS: We performed a retrospective review of percutaneous core biopsies performed at our institution from January 2002 through February 2008. Data were collected at the time of biopsy, and clinical information was obtained 24 hours and 3 months after the biopsy. The specific information that was collected included the results of coagulation studies, aspirin use, the organ biopsied, the size of the biopsy needle, and the number of needle passes...
March 2010: AJR. American Journal of Roentgenology
S Martha, K R Devarakonda, R N R Anreddy, N Pantam
In the present study, we aimed to investigate the role of aspirin in preventing type 2 diabetes in rats. At 5 days old, rat pups were divided into four groups. Group I pups received citrate buffer solution and served as control; group II was treated only with streptozotocin (80 mg/kg i.p.) and served as the diabetic control; groups III and IV were treated with aspirin (10 mg/kg/day p.o.) for 1 and 2 months, respectively, after streptozotocin treatment and served as treated groups. During weeks 8 and 10, blood samples were collected from all animals and fasting blood sugar, fasting insulin, insulin resistance and insulin sensitivity were determined...
June 2009: Methods and Findings in Experimental and Clinical Pharmacology
Wenping Zhao, Gerardo G Mackenzie, Onika T Murray, Zhiquan Zhang, Basil Rigas
Aspirin is chemopreventive against colon and probably other cancers, but this effect is relatively weak and its chronic administration to humans is associated with significant side effects. Because of these limitations, extensive effort has been exerted to improve the pharmacological properties of aspirin. We have determined the anticancer activity and mechanisms of action of the novel para positional isomer of phosphoaspirin [P-ASA; MDC-43; 4-((diethoxyphosphoryloxy)methyl)phenyl 2-acetoxybenzoate]. P-ASA inhibited the growth of 10 human cancer cell lines originating from colon, lung, liver, pancreas and breast, at least 18- to 144-fold more potently than conventional aspirin...
March 2009: Carcinogenesis
Guillermo Robles-Díaz, Daniela Fastag
No abstract text is available yet for this article.
November 2007: Revista de Gastroenterología de México
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