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https://www.readbyqxmd.com/read/28810595/sudoscan-an-effective-tool-for-screening-chronic-kidney-disease-in-patients-with-type-2-diabetes
#1
Fei Mao, Siying Liu, Xiaona Qiao, Hangping Zheng, Qian Xiong, Jie Wen, Shuo Zhang, Zhaoyun Zhang, Hongying Ye, Hongli Shi, Bin Lu, Yiming Li
SUDOSCAN is a non-invasive method of measuring peripheral small fiber and autonomic nerve activity by detection of abnormal sweat gland function through electrochemical skin conductance. It has been reported to be an effective screening tool in early detection of microvascular type 2 diabetes mellitus (T2DM) complications including diabetic neuropathy and nephropathy in recent studies. However, previous studies used estimated glomerular filtration rate (eGFR) as the golden standard, which has a 90% chance of being within 30% of the measured GFR at best...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807718/autonomic-regulation-of-systemic-inflammation-in-humans-a-multi-center-blinded-observational-cohort-study
#2
Gareth L Ackland, Gary Minto, Martin Clark, John Whittle, Robert Cm Stephens, Thomas Owen, Pradeep Prabhu, Ana Gutierrez Del Arroyo
OBJECTIVE: Experimental animal models demonstrate that autonomic activity regulates systemic inflammation. By contrast, human studies are limited in number and exclusively use heart rate variability (HRV) as an index of cardiac autonomic regulation. HRV measures are primarily dependent on, and need to be corrected for, heart rate. Thus, independent autonomic measures are required to confirm HRV-based findings. Here, the authors sought to replicate the findings of preceding HRV-based studies by using HRV-independent, exercise-evoked sympathetic and parasympathetic measures of cardiac autonomic regulation to examine the relationship between autonomic function and systemic inflammation...
August 11, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28802637/blood-pressure-responses-to-dietary-sodium-association-with-autonomic-cardiovascular-function-in-normotensive-adults
#3
Evan L Matthews, Michael S Brian, David G Edwards, Sean D Stocker, Megan M Wenner, William B Farquhar
Blood pressure responses to dietary sodium vary widely person-to-person. Salt sensitive rodent models display altered autonomic function, a trait thought to contribute to poor cardiovascular health. Thus, we hypothesized that increased salt sensitivity (SS) in normotensive humans would be associated with increased muscle sympathetic nerve activity (MSNA), decreased high frequency heart rate variability (HF-HRV), and decreased baroreflex sensitivity. Healthy normotensive men and women completed 1week of high (300mmol·day(-1)) and 1week of low (20mmol·day(-1)) dietary sodium (random order) with 24h mean arterial pressure (MAP) assessed on the last day of each diet to assess SS...
August 6, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28800081/autonomic-dysfunction-after-mild-traumatic-brain-injury
#4
Dmitry Esterov, Brian D Greenwald
A mild traumatic brain injury (mTBI) is a complex pathophysiologic process that has a systemic effect on the body aside from solely an impairment in cognitive function. Dysfunction of the autonomic nervous system (ANS) has been found to induce abnormalities in organ systems throughout the body, and may contribute to cardiovascular dysregulation and increased mortality. Autonomic dysfunction, also known as dysautonomia, has been studied in moderate and severe TBI, and has emerged as a major contributing factor in the symptomatology in mTBI as well...
August 11, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28798722/autonomic-neuropathy-and-albuminocytologic-dissociation-in-cerebrospinal-fluid-as-the-presenting-features-of-primary-amyloidosis-a-case-report
#5
Jingjing Li, Yi Li, Hongbing Chen, Shihui Xing, Huiyu Feng, Dawei Liu, Dilong Wang, Jinsheng Zeng, Yuhua Fan
OBJECTIVE: Primary amyloidosis is a disease with a poor prognosis and multi-organ involvement. Here, we report the clinical and pathological features of a patient with primary amyloidosis featuring autonomic neuropathy as the initial symptom and albuminocytologic dissociation in the cerebrospinal fluid (CSF). METHODS: The patient was a 60-year-old Chinese male with numbness, orthostatic hypotension, and gastrointestinal symptoms. For diagnosis, we performed an electromyogram (EMG), lumbar puncture, Bence Jones protein urine test, serum electrophoresis blood test, sural nerve and rectal membrane biopsies, transthyretin (TTR) gene sequencing, and bone marrow puncture...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28798255/benefits-of-oxytocin-administration-in-obstructive-sleep-apnea
#6
Vivek Jain, Joseph Marbach, Shawn Kimbro, David C Andrade, Arad Jain, Eleanor Capozzi, Kyle Mele, Rodrigo Del Rio, Matthew W Kay, David Mendelowitz
Activation of oxytocin receptors has shown benefits in animal models of Obstructive Sleep Apnea (OSA). We tested if nocturnal oxytocin administration could have beneficial effects in OSA patients. 8 patients diagnosed with OSA were administered intranasal oxytocin (40 i.u.). Changes in cardiorespiratory events during sleep, including apnea and hypopnea durations and frequency, risk of event-associated arousals, and heart rate variability were assessed. Oxytocin significantly increased indices of parasympathetic activity, including heart rate variability, total sleep time, and the Post-Polysommogram Sleep Assessment (PPSA) score, an index of self-reported sleep satisfaction...
August 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28790913/the-dual-role-of-microglia-in-als-mechanisms-and-therapeutic-approaches
#7
REVIEW
Maria Concetta Geloso, Valentina Corvino, Elisa Marchese, Alessia Serrano, Fabrizio Michetti, Nadia D'Ambrosi
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a non-cell autonomous motor neuron loss. While it is generally believed that the disease onset takes place inside motor neurons, different cell types mediating neuroinflammatory processes are considered deeply involved in the progression of the disease. On these grounds, many treatments have been tested on ALS animals with the aim of inhibiting or reducing the pro-inflammatory action of microglia and astrocytes and counteract the progression of the disease...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28783049/an-optimized-data-distribution-service-based-solution-for-reliable-data-exchange-among-autonomous-underwater-vehicles
#8
Jesús Rodríguez-Molina, Sonia Bilbao, Belén Martínez, Mirgita Frasheri, Baran Cürüklü
Major challenges are presented when managing a large number of heterogeneous vehicles that have to communicate underwater in order to complete a global mission in a cooperative manner. In this kind of application domain, sending data through the environment presents issues that surpass the ones found in other overwater, distributed, cyber-physical systems (i.e., low bandwidth, unreliable transport medium, data representation and hardware high heterogeneity). This manuscript presents a Publish/Subscribe-based semantic middleware solution for unreliable scenarios and vehicle interoperability across cooperative and heterogeneous autonomous vehicles...
August 5, 2017: Sensors
https://www.readbyqxmd.com/read/28782130/left-atrial-phasic-function-and-heart-rate-variability-in-patients-with-systemic-sclerosis-a-new-part-of-the-old-puzzle
#9
Marijana Tadic, Maja Zlatanovic, Cesare Cuspidi, Ana Stevanovic, Vesna Kocijancic, Sinisa U Pavlovic, Nemanja Damjanov, Vera Celic
OBJECTIVE: We aimed to research left atrial (LA) phasic function and heart rate variability (HRV), as well as their relationship, in subjects with uncomplicated systemic sclerosis (SSc). METHODS: The investigation involved 44 SSc patients and 33 age-matched healthy controls. All participants underwent clinical examination, serological tests, 24-hours Holter monitoring, and echocardiographic examination including strain analysis. RESULTS: Maximum, minimum, and pre-A LA volumes and volume indices were higher in the SSc patients than in the controls...
August 7, 2017: Echocardiography
https://www.readbyqxmd.com/read/28779873/spatially-defined-motor-deficits-in-people-with-unilateral-complex-regional-pain-syndrome
#10
Emily J Reid, Felicity A Braithwaite, Sarah B Wallwork, Daniel Harvie, K Jane Chalmers, Charles Spence, Alberto Gallace, G Lorimer Moseley
OBJECTIVE: Spatially-defined disruption of autonomic and sensory function has been identified in Complex Regional Pain Syndrome (CRPS). This study aimed to determine whether motor performance is also disrupted in a spatially-defined manner in people with CRPS. METHODS: Thirteen people with CRPS type 1 of the upper limb participated in two motor experiments. In Experiment 1 participants performed a circle drawing task that primarily tested motor accuracy. In Experiment 2 participants performed a button pressing task that tested motor co-ordination...
July 14, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28774735/an-autonomous-automated-and-mobile-device-to-concurrently-assess-several-cognitive-functions-in-group-living-non-human-primates
#11
Fizet Jonas, Rimele Adam, Pebayle Thierry, Cassel Jean-Christophe, Kelche Christian, Meunier Hélène
Research methods in cognitive neuroscience using non-human primates have undergone notable changes over the last decades. Recently, several research groups have described freely accessible devices equipped with a touchscreen interface. Two characteristics of such systems are of particular interest: some apparatuses include automated identification of subjects, while others are mobile. Here, we designed, tested and validated an experimental system that, for the first time, combine automatization and mobility...
July 31, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28770543/feasibility-and-safety-of-virtual-reality-based-early-neurocognitive-stimulation-in-critically-ill-patients
#12
Marc Turon, Sol Fernandez-Gonzalo, Mercè Jodar, Gemma Gomà, Jaume Montanya, David Hernando, Raquel Bailón, Candelaria de Haro, Victor Gomez-Simon, Josefina Lopez-Aguilar, Rudys Magrans, Melcior Martinez-Perez, Joan Carles Oliva, Lluís Blanch
BACKGROUND: Growing evidence suggests that critical illness often results in significant long-term neurocognitive impairments in one-third of survivors. Although these neurocognitive impairments are long-lasting and devastating for survivors, rehabilitation rarely occurs during or after critical illness. Our aim is to describe an early neurocognitive stimulation intervention based on virtual reality for patients who are critically ill and to present the results of a proof-of-concept study testing the feasibility, safety, and suitability of this intervention...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28770033/epicardial-fat-thickness-is-correlated-with-vagal-hyperactivity-in-patients-with-neurally-mediated-syncope
#13
Kyoung Im Cho, Young Soo Lee, Byong Kyu Kim, Bong Joon Kim, Kee Sik Kim
BACKGROUND: Epicardial fat tissue has unique endocrine and paracrine functions that affect the cardiac autonomic system. The head-up tilt test (HUTT) is a simple non-invasive measurement that assesses autonomic nervous system dysfunction. We investigated the association between epicardial fat thickness (EFT) and autonomic neural tone, such as vagal tone. METHODS: A total of 797 consecutive patients (mean age 46.5 years, male: 45.7%) who underwent HUTT and echocardiography between March 2006 and June 2015 were enrolled...
June 2017: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28766984/long-term-effect-of-parasympathetic-or-sympathetic-denervation-on-intestinal-epithelial-cell-proliferation-and-apoptosis
#14
Elizabeth A Davis, Martha C Washington, Emily R Yaniz, Heidi Phillips, Ayman I Sayegh, Megan J Dailey
Intestinal epithelial tissue is constantly regenerated as a means to maintain proper tissue function. Previous studies have demonstrated that denervation of the parasympathetic or sympathetic nervous system to the intestine alters this process. However, results are inconsistent between studies, showing both increases and decreases in proliferation after denervation of the parasympathetic or sympathetic. The effect appears to correlate with (1) the timing post-denervation, (2) denervation-induced changes in food intake, (3) the denervation technique used, and (4) which intestinal segment is investigated...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28765629/subthalamic-nucleus-stimulation-and-levodopa-modulate-cardiovascular-autonomic-function-in-parkinson-s-disease
#15
Kai Li, Rocco Haase, Heinz Rüdiger, Manja Reimann, Heinz Reichmann, Martin Wolz, Tjalf Ziemssen
We aimed to explore the effects of bilateral subthalamic nucleus stimulation and levodopa on cardiovascular autonomic function in Parkinson's disease. Twenty-six Parkinson's disease patients with bilateral subthalamic nucleus stimulation in a stable state were tested under stimulation off and dopaminergic medication off (OFF-OFF), stimulation on and dopaminergic medication off (ON-OFF), and stimulation on and medication (levodopa) on (ON-ON) conditions by recording continuously blood pressure, ECG, and respiration at rest, during metronomic deep breathing, and head-up tilt test...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764300/effect-of-pranayama-on-ppar-%C3%AE-nf-%C3%AE%C2%BAb-expressions-and-red-complex-microorganisms-in-patients-with-chronic-periodontitis-a-clinical-trial
#16
Jaideep Mahendra, Little Mahendra, R Ananthalakshmi, Prathahini S Parthiban, Sandhya Cherukuri, Mohammed Junaid
INTRODUCTION: Sudarshankriya pranayama is the control of breathing movements to regulate the energy flow throughout the body, which has shown to positively affect immune function, autonomic nervous system and psychologic-neuro pathways. The practice of pranayama has been proven to show several benefits such as reduction in stress levels, relieves anxiety and depression, increase in antioxidant levels, reduces insulin resistance and improves respiratory function. AIM: The objective of the study was to evaluate the levels of Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ), Nuclear Factor-Kappa B (NF-κB) and the presence of Red Complex Microorganisms (RCM) such as Treponema denticola, Porphyromonas gingivalis and Tannerella forsythia in the subgingivalpl aque samples of chronic periodontitis subjects before and after intervention with pranayama as an adjunct to Scaling and Root Planing (SRP)...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28752607/reproducibility-of-heart-rate-recovery-in-patients-with-intermittent-claudication
#17
Rafael Yokoyama Fecchio, Marcel Chehuen, Tiago Peçanha, Gabriel Grizzo Cucato, Luiz Augusto Riani Costa, Anthony Scott Leicht, Raphael Mendes Ritti-Dias, Nelson Wolosker, Cláudia Lúcia de Moraes Forjaz
BACKGROUND: Postexercise heart rate recovery (HRR) is a non-invasive tool for cardiac autonomic function assessment. Reproducibility of HRR has been established in healthy subjects; however, no study has evaluated this reproducibility in clinical populations who may present autonomic dysfunction. Patients with peripheral artery disease and intermittent claudication (IC) often present altered cardiac autonomic function and HRR could be an interesting tool for evaluating autonomic responses to interventions in this population...
July 28, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28747449/loss-of-cutaneous-large-and-small-fibers-in-naive-and-l-dopa-treated-pd-patients
#18
Maria Nolano, Vincenzo Provitera, Fiore Manganelli, Rosa Iodice, Annamaria Stancanelli, Giuseppe Caporaso, Annamaria Saltalamacchia, Francesca Califano, Bernardo Lanzillo, Marina Picillo, Paolo Barone, Lucio Santoro
OBJECTIVE: To study small and large fiber pathology in drug-naive and l-dopa-treated patients affected by Parkinson disease (PD) in early phases, before the occurrence of neuropathic electrophysiologic abnormalities. METHODS: We enrolled 85 patients with idiopathic PD (male/female 49/36, age 61.3 ± 9.7 years) without electrophysiologic signs of neuropathy, including 48 participants naive to l-dopa treatment. All patients underwent clinical, functional, and morphologic assessment of sensory and autonomic nerves through dedicated questionnaires, quantitative sensory testing, sympathetic skin response, dynamic sweat test, and punch biopsies from glabrous and hairy skin...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28742137/water-immersion-decreases-sympathetic-skin-response-during-color-word-stroop-test
#19
Daisuke Sato, Yudai Yamazaki, Akari Takahashi, Yoshihito Uetake, Saki Nakano, Kaho Iguchi, Yasuhiro Baba, Rio Nara, Yoshimitsu Shimoyama
Water immersion alters the autonomic nervous system (ANS) response in humans. The effect of water immersion on executive function and ANS responses related to executive function tasks was unknown. Therefore, this study aimed to determine whether water immersion alters ANS response during executive tasks. Fourteen healthy participants performed color-word-matching Stroop tasks before and after non-immersion and water immersion intervention for 15 min in separate sessions. The Stroop task-related skin conductance response (SCR) was measured during every task...
2017: PloS One
https://www.readbyqxmd.com/read/28741870/impact-of-functional-training-on-geometric-indices-and-fractal-correlation-property-of-heart-rate-variability-in-postmenopausal-women
#20
Marianne P da C de Rezende Barbosa, Luiz C M Vanderlei, Lucas M Neves, Carolina Takahashi, Paula R Dos S Torquato, Ana Claúdia de S Fortaleza, Ismael F Freitas Júnior, Isabel C E Sorpreso, Luiz C Abreu, Andrés R Pérez Riera
BACKGROUND: To evaluate the influence of functional training on the geometric indices of heart rate variability (HRV) and fractal correlation properties of the dynamics of heart rate in menopausal women. METHODS: Of 39 women who were in the period of menopause for more than a year and who did not practice any regular physical activity were divided into: Functional training group (FTG = 50 ± 4.5 years; 67.64 ± 11.64 kg; 1.5 ± 0.05 m) that executed the functional training (FT) and all proposals by reviews and the Control group (58...
July 25, 2017: Annals of Noninvasive Electrocardiology
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