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https://www.readbyqxmd.com/read/28238817/the-relationship-between-maternal-responsivity-socioeconomic-status-and-resting-autonomic-nervous-system-functioning-in-mexican-american-children
#1
Megan Johnson, Julianna Deardorff, Elizabeth L Davis, William Martinez, Brenda Eskenazi, Abbey Alkon
Adversity, such as living in poor socioeconomic conditions during early childhood, can become embedded in children's physiology and deleteriously affect their health later in life. On the other hand, maternal responsivity may have adaptive effects on physiology during early childhood development. The current study tested both the additive and interactive effects of socioeconomic status (SES) and maternal responsivity measured at 1year of age on resting autonomic nervous system (ANS) function and trajectory during the first 5years of life...
February 23, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28236615/effects-of-music-therapy-on-endothelial-function-in-patients-with-coronary-artery-disease-participating-in-aerobic-exercise-therapy
#2
Marina Deljanin Ilic, Radmila F Pavlovic, Gordana Kocic, Dejan Simonovic, Gordana Lazarevic
Context • Pleasant music that evokes a positive emotional response may activate brain pathways of the insular cortex, central nucleus of the amygdala, and lateral hypothalamus, which are involved in the integration of emotional and ambient sensory input, with corresponding autonomic responses. Exercise training can improve endothelium-dependent vasodilatation, both in epicardial coronary vessels and in resistance vessels, for patients with coronary heart disease. Objective • The aim of the present study was to evaluate the effects on endothelial function when patients with stable coronary artery disease (CAD) listened to their favorite music...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28235865/deficiency-in-il-1-receptor-type-2-aggravates-k-bxn-serum-transfer-induced-arthritis-in-mice-but-has-no-impact-on-systemic-inflammatory-responses
#3
Praxedis Martin, Gaby Palmer, Emiliana Rodriguez, Christian Alexander Seemayer, Jennifer Palomo, Dominique Talabot-Ayer, Cem Gabay
The biological activity of IL-1 is tightly regulated by the specific receptor antagonist (IL-1Ra) and the decoy receptor IL-1 receptor type 2 (IL-1R2). The role of IL-1Ra has been well demonstrated in IL-1Ra-deficient mice. In contrast, the role of endogenous IL-1R2 remains widely unknown. To define the functional role of endogenous IL-1R2 in the K/BxN serum transfer arthritis model and in IL-1β- or LPS-induced systemic inflammation in vivo, IL-1R2(-/-) mice were created and compared with wild type mice. IL-1R2(-/-) mice bred habitually and exhibited a normal phenotype...
February 24, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28228721/patients-with-chronic-spinal-cord-injury-exhibit-reduced-autonomic-modulation-during-an-emotion-recognition-task
#4
Gonzalo Varas-Díaz, Enzo P Brunetti, Gonzalo Rivera-Lillo, Pedro E Maldonado
Spinal cord injury (SCI) is a devastating event for individuals, who frequently develop motor and sensory impairment as well as autonomic dysfunction. Previous studies reported that autonomic activity plays a major role in social cognition and that difficulties in the ability to interpret social information are commonly observed in a variety of mental disorders, which in turn correlate with a poor autonomic nervous system (ANS) regulation. It is well established that subjects with SCI have an alteration in ANS regulation mechanisms...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28227072/short-term-assessment-of-autonomic-nervous-system-as-a-potential-tool-to-quantify-pain-experience
#5
Arto J Hautala, Jaro Karppinen, Tapio Seppanen, Arto J Hautala, Jaro Karppinen, Tapio Seppanen, Jaro Karppinen, Arto J Hautala, Tapio Seppanen
Various pain conditions may result in altered autonomic nervous system regulation. We evaluated whether autonomic regulation, analyzed with short-term heart rate variability (HRV), differs between low back pain (LBP) patients and healthy controls. Additionally, we tested if short-term HRV recordings are feasible and informative in planning home monitoring of LBP patients. The study population consisted of 16 volunteers (8 LBP patients and 8 healthy subjects) (age 42±10 years, body mass index 26±4 kg/m(2), 7 men and 9 women)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226649/heart-rate-independent-qt-variability-component-can-detect-subclinical-cardiac-autonomic-neuropathy-in-diabetes
#6
Mohammad H Imam, Chandan K Karmakar, Ahsan H Khandoker, Herbert F Jelinek, M Palaniswami, Mohammad H Imam, Chandan K Karmakar, Ahsan H Khandoker, Herbert F Jelinek, M Palaniswami, Ahsan H Khandoker, Herbert F Jelinek, Chandan K Karmakar, Mohammad H Imam, M Palaniswami
Cardiac autonomic neuropathy (CAN) may lead to life threatening arrhythmia due to denervation of both the parasympathetic and sympathetic branches of autonomic nervous system innervating the heart. CAN is a frequently under diagnosed complication of diabetes, because a patient can have asymptomatic CAN for several years before it is clinically apparent. However, detection of CAN at the early or subclinical stage leads to more effective treatment outcomes. Cardiac autonomic reflex tests (CART) (i.e. Ewing test battery) are normally used for the detection and staging of CAN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222894/the-relationship-between-left-ventricular-deformation-and-heart-rate-variability-in-patients-with-systemic-sclerosis-two-and-three-dimensional-strain-analysis
#7
Marijana Tadic, Maja Zlatanovic, Cesare Cuspidi, Branislava Ivanovic, Ana Stevanovic, Nemanja Damjanov, Vesna Kocijancic, Vera Celic
OBJECTIVE: We sought to investigate left ventricular (LV) function and deformation, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). METHODS: The study included 49 SSc patients and 38 age-matched healthy subjects. All patients underwent clinical examination, serological tests, 24-h Holter monitoring, and comprehensive two- and three-dimensional echocardiography (2DE and 3DE). RESULTS: 2DE and 3DE LV global longitudinal and circumferential strain, as well as 3DE area strains are significantly reduced in SSc patients comparing with controls...
February 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28216645/a-3-5-exonuclease-activity-embedded-in-the-helicase-core-domain-of-candida-albicans-pif1-helicase
#8
Xiao-Bin Wei, Bo Zhang, Nicolas Bazeille, Ying Yu, Na-Nv Liu, Brigitte René, Olivier Mauffret, Xu-Guang Xi
3'-5' exonucleases are frequently found to be associated to polymerases or helicases domains in the same enzyme or could function as autonomous entities. Here we uncovered that Candida albicans Pif1 (CaPif1) displays a 3'-5' exonuclease activity besides its main helicase activity. These two latter activities appear to reside on the same polypeptide and the new exonuclease activity could be mapped to the helicase core domain. We clearly show that CaPif1 displays exclusively exonuclease activity and unambiguously establish the directionality of the exonuclease activity as the 3'-to-5' polarity...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28213205/sensory-trigeminal-ulf-tens-stimulation-reduces-hrv-response-to-experimentally-induced-arithmetic-stress-a-randomized-clinical-trial
#9
Annalisa Monaco, Ruggero Cattaneo, Eleonora Ortu, Marian Vladimir Constantinescu, Davide Pietropaoli
Ultra Low Frequency Transcutaneous Electric Nervous Stimulation (ULF-TENS) is extensively used for pain relief and for the diagnosis and treatment of temporomandibular disorders (TMD). In addition to its local effects, ULF-TENS acts on the autonomic nervous system (ANS), with particular reference to the periaqueductal gray (PAG), promoting the release of endogenous opioids and modulating descending pain systems. It has been suggested that the PAG participates in the coupling between the emotional stimulus and the appropriate behavioral autonomic response...
February 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28196692/shisa6-confers-resistance-to-differentiation-promoting-wnt-%C3%AE-catenin-signaling-in-mouse-spermatogenic-stem-cells
#10
Moe Tokue, Kanako Ikami, Seiya Mizuno, Chiyo Takagi, Asuka Miyagi, Ritsuko Takada, Chiyo Noda, Yu Kitadate, Kenshiro Hara, Hiroko Mizuguchi, Takuya Sato, Makoto Mark Taketo, Fumihiro Sugiyama, Takehiko Ogawa, Satoru Kobayashi, Naoto Ueno, Satoru Takahashi, Shinji Takada, Shosei Yoshida
In the seminiferous tubules of mouse testes, a population of glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRα1)-positive spermatogonia harbors the stem cell functionality and supports continual spermatogenesis, likely independent of asymmetric division or definitive niche control. Here, we show that activation of Wnt/β-catenin signaling promotes spermatogonial differentiation and reduces the GFRα1(+) cell pool. We further discovered that SHISA6 is a cell-autonomous Wnt inhibitor that is expressed in a restricted subset of GFRα1(+) cells and confers resistance to the Wnt/β-catenin signaling...
February 7, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28196077/enhancer-of-polycomb-coordinates-multiple-signaling-pathways-to-promote-both-cyst-and-germline-stem-cell-differentiation-in-the-drosophila-adult-testis
#11
Lijuan Feng, Zhen Shi, Xin Chen
Stem cells reside in a particular microenvironment known as a niche. The interaction between extrinsic cues originating from the niche and intrinsic factors in stem cells determines their identity and activity. Maintenance of stem cell identity and stem cell self-renewal are known to be controlled by chromatin factors. Herein, we use the Drosophila adult testis which has two adult stem cell lineages, the germline stem cell (GSC) lineage and the cyst stem cell (CySC) lineage, to study how chromatin factors regulate stem cell differentiation...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28190795/progress-in-understanding-the-molecular-functions-of-ddx3y-dby-in-male-germ-cell-development-and-maintenance
#12
Alexei A Kotov, Oxana M Olenkina, Baira K Godneeva, Vladimir E Adashev, Ludmila V Olenina
Human DDX3 paralogs are housed on the X chromosome (DDX3X) as well as in the non- recombining region Yq11 of the Y-chromosome (DDX3Y or DBY). A gene encoding RNA helicase DDX3Y is located in the AZoospermia Factor a (AZFa) region of the Y-chromosome and expressed only in male germ cells. Deletions encompassing the DDX3Y gene lead to azoospermia and cause Sertoli Cell-Only Syndrome (SCOS) in humans. SCOS is characterized by a complete germ cell lack with preservation of somatic Sertoli cells. This review summarizes current advances in the study of DDX3Y functions in maintenance and development of early male germ cells...
February 12, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28186393/chronic-fatigue-in-ehlers-danlos-syndrome-hypermobile-type
#13
Alan Hakim, Inge De Wandele, Chris O'Callaghan, Alan Pocinki, Peter Rowe
Chronic fatigue is an important contributor to impaired health-related quality of life in Ehlers-Danlos syndrome. There is overlap in the symptoms and findings of EDS and chronic fatigue syndrome. A proportion of those with CFS likely have EDS that has not been identified. The evaluation of chronic fatigue in EDS needs to include a careful clinical examination and laboratory testing to exclude common causes of fatigue including anemia, hypothyroidisim, and chronic infection, as well as dysfunction of major physiological or organ systems...
February 10, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28184201/long-term-high-fat-diet-treatment-an-appropriate-approach-to-study-the-sex-specificity-of-the-autonomic-and-cardiovascular-responses-to-obesity-in-mice
#14
Thiago Bruder-Nascimento, Obioma J Ekeledo, Ruchi Anderson, Huy B Le, Eric J Belin de Chantemèle
Obesity-related cardiovascular disease (CVD) involves increased sympathetic activity in men and male animals. Although women exhibit increased visceral fat, metabolic disorders, inflammation and CVD with obesity, whether body weight gain affects autonomic control of cardiovascular function in females remain unknown. Due to the lack of adequate model to mimic the human pathology, this study aimed to develop a murine model, which would allow studying the sex-specificity of the response of the autonomic nervous system to obesity and identifying the origin of potential sex-differences...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28181258/cardiac-diastolic-and-autonomic-dysfunction-are-aggravated-by-central-chemoreflex-activation-in-hfpef-rats
#15
Camilo Toledo, David C Andrade, Claudia Lucero, Alexis Arce-Alvarez, Hugo S Díaz, Valentín Aliaga, Harold D Schultz, Noah J Marcus, Mónica Manríquez, Marcelo Faúndez, Rodrigo Del Rio
Heart failure (HF) patients with preserved ejection fraction (HFpEF) display irregular breathing, sympatho-vagal imbalance, arrhythmias, and diastolic dysfunction. It has been shown that tonic activation of central and peripheral chemoreflex pathway plays a pivotal role in the pathophysiology of HF with reduced ejection fraction. In contrast, no studies to date have addressed chemoreflex function or its effect on cardiac function in HFpEF. Therefore, we tested whether peripheral and central chemoreflexes are hyperactive in HFpEF and if chemoreflex activation exacerbates cardiac dysfunction and autonomic imbalance...
February 8, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28174525/cardiac-signals-are-independently-associated-with-temporal-discounting-and-time-perception
#16
Bowen J Fung, Damien L Crone, Stefan Bode, Carsten Murawski
Cardiac signals reflect the function of the autonomic nervous system (ANS) and have previously been associated with a range of self-regulatory behaviors such as emotion regulation and memory recall. It is unknown whether cardiac signals may also be associated with self-regulation in the temporal domain, in particular impulsivity. We assessed both decision impulsivity (temporal discounting, TD) and time perception impulsivity (duration reproduction, DR) in 120 participants while they underwent electrocardiography in order to test whether cardiac signals were related to these two aspects of impulsivity...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28167918/quantifying-effects-of-pharmacological-blockers-of-cardiac-autonomous-control-using-variability-parameters
#17
Renata Miyabara, Karsten Berg, Jan F Kraemer, Ovidiu C Baltatu, Niels Wessel, Luciana A Campos
Objective: The aim of this study was to identify the most sensitive heart rate and blood pressure variability (HRV and BPV) parameters from a given set of well-known methods for the quantification of cardiovascular autonomic function after several autonomic blockades. Methods: Cardiovascular sympathetic and parasympathetic functions were studied in freely moving rats following peripheral muscarinic (methylatropine), β1-adrenergic (metoprolol), muscarinic + β1-adrenergic, α1-adrenergic (prazosin), and ganglionic (hexamethonium) blockades...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28166944/recover-of-peripheral-nerve-function-after-prolong-hypothermic-cardiac-arrest-in-a-porcine-model-with-extra-corporeal-life-support
#18
Benedict Kjaergaard, Cristian Sevcencu, Sigridur Olga Magnusdottir, Henrik Bygum Krarup, Thomas Nørgaard Nielsen
OBJECTIVES: Surviving long lasting cardiac arrest following accidental hypothermia has been reported after treatment with extra corporeal life support (ECLS), but there is a risk of neurologic injury. Most surviving hypothermia patients have a prolonged stay in the intensive care unit, where most patients experience polyneuropathy. Theoretically, accidental hypothermic cardiac arrest may in itself contribute to polyneuropathy. This study was designed to examine the impact of three hours of cardiac arrest at a core temperature of 20°C followed by reanimation of peripheral nerve function...
February 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28166422/relation-of-heart-rate-recovery-after-exercise-testing-to-coronary-artery-calcification
#19
Sae Young Jae, Sudhir Kurl, Jari A Laukkanen, Eun Sun Yoon, Yoon-Ho Choi, Bo Fernhall, Barry A Franklin
BACKGROUND: We examined whether slow heart rate recovery (HRR) after exercise testing as an estimate of impaired autonomic function is related to coronary artery calcification (CAC), an emerging marker of coronary atherosclerosis. METHODS: We evaluated 2088 men who participated in a health screening program that included measures of CAC and peak or symptom-limited cardiopulmonary exercise testing. HRR was calculated as the difference between peak heart rate during exercise testing and the heart rate at 2 minutes of recovery after peak exercise...
February 6, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28160388/cardiovascular-autonomic-dysfunction-in-ehlers-danlos-syndrome-hypermobile-type
#20
Alan Hakim, Chris O'Callaghan, Inge De Wandele, Lauren Stiles, Alan Pocinki, Peter Rowe
Autonomic dysfunction contributes to health-related impairment of quality of life in the hypermobile type of Ehlers-Danlos syndrome (hEDS). Typical signs and symptoms include tachycardia, hypotension, gastrointestinal dysmotility, and disturbed bladder function and sweating regulation. Cardiovascular autonomic dysfunction may present as Orthostatic Intolerance, Orthostatic Hypotension, Postural Orthostatic Tachycardia Syndrome, or Neurally Mediated Hypotension. The incidence, prevalence, and natural history of these conditions remain unquantified, but observations from specialist clinics suggest they are frequently seen in hEDS...
February 4, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
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