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https://www.readbyqxmd.com/read/28528135/presymptomatically-applied-ampa-receptor-antagonist-prevents-calcium-increase-in-vulnerable-type-of-motor-axon-terminals-of-mice-modeling-amyotrophic-lateral-sclerosis
#1
Roland Patai, Melinda Paizs, Massimo Tortarolo, Caterina Bendotti, Izabella Obál, József I Engelhardt, László Siklós
Increased intracellular calcium (Ca), which might be the consequence of an excess influx through Ca-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, plays a crucial role in degeneration of motor neurons. Previously we demonstrated that the presymptomatic application of AMPA receptor antagonist, talampanel, could reduce Ca elevation in spinal motor neurons of mice carrying the G93A mutation of superoxide dismutase 1 (SOD1), modeling amyotrophic lateral sclerosis (ALS). It remained to be examined whether the remote, functionally semi-autonomous motor axon terminals could be rescued from the Ca overload, or if the terminals, where the degeneration possibly starts, already experience intractable changes at early time points...
May 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28508810/timed-up-and-go-device-for-unsupervised-functional-assessment-of-elderly-patients
#2
Andreas Ziegl, Robert Modre-Osprian, Alberto Sánchez, Markus Falgenhauer, Peter Kastner, Günter Schreier
Functional evaluation of elderly patients is one key component in a comprehensive Geriatric Assessment. The increased workload and high costs associated to close and continuous monitoring in clinical settings may be counterbalanced by the application of ICT-supported remote follow-up. Although clinical parameters and questionnaires can be supported with smartphones and smart gadgets, physical performance trials pose a challenge for community-based approaches with difficulties arising from setting up trials, the lack of guidance and supervision...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28506500/autonomic-and-electrocardiographic-findings-in-parkinson-s-disease
#3
Christopher H Gibbons, David K Simon, Meilin Huang, Barbara Tilley, Michael J Aminoff, Jacquelyn L Bainbridge, Matthew Brodsky, Roy Freeman, John Goudreau, Robert W Hamill, Sheng T Luo, Carlos Singer, Aleksandar Videnovic, Ivan Bodis-Wollner, Pei S Wong
Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms and signs. Many reports suggest that diminished heart rate variability occurs early, even prior to the cardinal signs of PD. In a longitudinal study of PD, we evaluated whether heart rate variability (HRV) obtained using a 10-second ECG tracing, and the electrocardiographic QT-interval would be associated with PD severity and progression. Subjects were derived from a longitudinal study of 1741 individuals with early, stable PD...
April 14, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28506121/mammalian-circadian-period-but-not-phase-and-amplitude-is-robust-against-redox-and-metabolic-perturbations
#4
Marrit Putker, Priya Crosby, Kevin A Feeney, Nathaniel P Hoyle, Ana S H da Costa, Edoardo Gaude, Christian Frezza, John Stuart O'Neill
AIMS: Circadian rhythms permeate all levels of biology to temporally regulate cell and whole-body physiology, although the cell-autonomous mechanism that confers ~24-hour periodicity is incompletely understood. Reports describing circadian oscillations of over-oxidised peroxiredoxin abundance have suggested redox signaling plays an important role in the timekeeping mechanism. Here, we tested the functional contribution that redox state and primary metabolism make to mammalian cellular timekeeping...
May 15, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28505992/the-influence-of-a-constraint-and-bimanual-training-program-using-a-variety-of-modalities-on-endurance-and-on-the-cardiac-autonomic-regulation-system-of-children-with-unilateral-cerebral-palsy-a-self-control-clinical-trial
#5
Marilyn Cohen-Holzer, Gilad Sorek, Maayan Schweizer, Michal Katz-Leurer
BACKGROUND: An intensive hybrid program, combining constraint with bimanual training, improves upper extremity function as well as walking endurance of children with unilateral cerebral palsy (UCP). Endurance improvement may be associated with the cardiac autonomic regulation system (CARS) adaptation, known to be impaired among these children. OBJECTIVE: To examine the influence of an intensive hybrid program on CARS, walking endurance and the correlation with upper extremity function of children with UCP...
May 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28491040/association-between-carotid-intima-media-thickness-and-heart-rate-variability-in-adults-at-increased-cardiovascular-risk
#6
Valter L Pereira, Mirela Dobre, Sandra G Dos Santos, Juliana S Fuzatti, Carlos R Oliveira, Luciana A Campos, Andrei Brateanu, Ovidiu C Baltatu
Background: Atherosclerotic carotid intima-media thickness (IMT) may be associated with alterations in the sensitivity of carotid baroreceptors. The aim of this study was to investigate the association between carotid IMT and the autonomic modulation of heart rate variability (HRV). Methods: A total of 101 subjects were enrolled in this prospective observational study. The carotid IMT was determined by duplex ultrasonography. The cardiac autonomic function was determined through HRV measures during the Deep Breathing Test...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28489609/heart-rate-based-window-segmentation-improves-accuracy-of-classifying-posttraumatic-stress-disorder-using-heart-rate-variability-measures
#7
Erik Reinertsen, Shamim Nemati, Adriana N Vest, Viola Vaccarino, Rachel Lampert, Amit J Shah, Gari D Clifford
OBJECTIVE: Heart rate variability (HRV) characterizes changes in autonomic nervous system function and varies with posttraumatic stress disorder (PTSD). In this study we developed a classifier based on heart rate (HR) and HRV measures, and improved classifier performance using a novel HR-based window segmentation. APPROACH: Single-channel ECG data were collected from 23 subjects with current PTSD, and 25 control subjects with no history of PTSD over 24 h. RR intervals were derived from these data, cleaned, and used to calculate HR and HRV metrics...
May 10, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28487967/comparative-analysis-of-the-beneficial-effects-of-treadmill-training-and-electroacupuncture-in-a-rat-model-of-neonatal-hypoxia-ischemia
#8
Ha Neui Kim, Malk Eun Pak, Myung Jun Shin, Soo Yeon Kim, Yong Beom Shin, Young Ju Yun, Hwa Kyoung Shin, Byung Tae Choi
In the present study, we investigated whether treadmill training and electroacupuncture (EA) have autonomous or synergistic beneficial effects on deficits caused by neonatal hypoxia‑ischemia in Sprague-Dawley rats. For this purpose, rats subjected to hypoxia-ischemia underwent treadmill training and EA stimulation from 4 to 8 weeks of age. Conventional EA (CEA) and scalp EA (SEA) were delivered by electrical stimulation (2 Hz, 1 mA) at traditional acupoints and at the scalp to the primary motor area, respectively...
June 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28487375/pulmonary-fibrosis-requires-cell-autonomous-mesenchymal-fibroblast-growth-factor-fgf-signaling
#9
Robert D Guzy, Ling Li, Craig Smith, Samuel J Dorry, Hyun Young Koo, Lin Chen, David M Ornitz
Idiopathic Pulmonary Fibrosis (IPF) is characterized by progressive pulmonary scarring, decline in lung function, and often results in death within three to five years after diagnosis. Fibroblast Growth Factor (FGF) signaling has been implicated in the pathogenesis of IPF; however, the mechanism through which FGF signaling contributes to pulmonary fibrosis remains unclear. We hypothesized that FGF receptor (FGFR) signaling in fibroblasts is required for the fibrotic response to bleomycin. To test this, mice with mesenchyme-specific tamoxifen-inducible inactivation of FGF receptors 1, 2, and 3 (Col1α2-CreER; TCKO mice) were lineage labeled and administered intratracheal bleomycin...
May 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28481623/does-japanese-citrus-fruit-yuzu-citrus-junos-sieb-ex-tanaka-fragrance-have-lavender-like-therapeutic-effects-that-alleviate-premenstrual-emotional-symptoms-a-single-blind-randomized-crossover-study
#10
Tamaki Matsumoto, Tetsuya Kimura, Tatsuya Hayashi
OBJECTIVE: A majority of menstruating women experience some degree of regular recurrences of diverse symptoms-commonly known as premenstrual syndrome (PMS)-during the days before menstruation. Given the multifactorial etiology of PMS, no single treatment is universally recognized as effective, and many women turn to alternative modalities, including aromatherapy. The present study investigated therapeutic effects on premenstrual symptoms using fragrance from yuzu, a Japanese citrus fruit (Citrus junos Sieb...
May 8, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28480859/the-effects-of-non-functional-overreaching-and-overtraining-on-autonomic-nervous-system-function-in-highly-trained-athletes
#11
T Kajaia, L Maskhulia, K Chelidze, V Akhalkatsi, Z Kakhabrishvili
Aim of the study was to compare the ANS functioning, as measured by heart rate variability (HRV), in athletes with non-functional overreaching (NFO) and overtraining syndrome (OTS) and in athletes without NFO/OTS. In 43 athletes with NFO/OTS, 40 athletes without NFO/OTS, as well as in 35 sedentary subjects the ANS function was evaluated with the Autonomic Balance Test, based on the HRV analysis of resting heart rate recordings. Results of the study show lower HRV and lower vagal influence along with increased sympathetic cardiovascular control in athletes with non-functional overreaching and particularly in athletes with overtraining, than in highly trained athletes without NFO/OTS...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28475588/widespread-position-specific-conservation-of-synonymous-rare-codons-within-coding-sequences
#12
Julie L Chaney, Aaron Steele, Rory Carmichael, Anabel Rodriguez, Alicia T Specht, Kim Ngo, Jun Li, Scott Emrich, Patricia L Clark
Synonymous rare codons are considered to be sub-optimal for gene expression because they are translated more slowly than common codons. Yet surprisingly, many protein coding sequences include large clusters of synonymous rare codons. Rare codons at the 5' terminus of coding sequences have been shown to increase translational efficiency. Although a general functional role for synonymous rare codons farther within coding sequences has not yet been established, several recent reports have identified rare-to-common synonymous codon substitutions that impair folding of the encoded protein...
May 5, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28468842/novel-mutations-in-dystonin-provide-clues-to-the-pathomechanisms-of-hsan-vi
#13
Fiore Manganelli, Silvia Parisi, Maria Nolano, Feifei Tao, Simona Paladino, Chiara Pisciotta, Stefano Tozza, Claudia Nesti, Adriana P Rebelo, Vincenzo Provitera, Filippo M Santorelli, Michael E Shy, Tommaso Russo, Stephan Zuchner, Lucio Santoro
OBJECTIVE: To describe a second hereditary sensory autonomic neuropathy type VI (HSAN-VI) family harboring 2 novel heterozygous mutations in the dystonin (DST) gene and to evaluate their effect on neurons derived from induced pluripotent stem cells (iPSC). METHODS: The family consisted of 3 affected siblings from nonconsanguineous healthy parents. All members underwent clinical and electrophysiologic evaluation and genetic analysis. Two patients underwent quantitative sensory testing (QST), cardiovascular reflexes, dynamic sweat test, and skin biopsy to evaluate somatic and autonomic cutaneous innervation and to get fibroblast cultures for developing iPSC-derived neurons...
May 3, 2017: Neurology
https://www.readbyqxmd.com/read/28462685/effect-of-heat-exposure-on-cognition-in-persons-with-tetraplegia
#14
John P Handrakis, Zhen Ni Guan, John W Nulty, Oriana Tascione, Dwindally Rosado-Rivera, Daniel White, Charlene Bang, Ann Spungen, William A Bauman
Individuals with cervical spinal cord injury (SCI) have impaired thermoregulatory mechanisms due to interruption of motor, sensory, and autonomic neuropathways. To determine the effects of heat exposure on core body temperature (Tcore) and cognitive performance in persons with tetraplegia, eight individuals with chronic tetraplegia (C3-C7, AIS A-B) and 9 able-bodied controls were acclimated to 27°C at baseline (BL) before being exposed to 35°C for up to 120 minutes (Heat Challenge). Rectal temperature (Tcore), distal skin temperatures (Tsk<sub>avg</sub>), sweat rate (QS<sub>avg</sub>), microvascular skin perfusion (LDF<sub>avg</sub>), and plasma norepinephrine (NE) were measured...
May 2, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28462079/loss-of-hepatic-deptor-alters-the-metabolic-transition-to-fasting
#15
Alexandre Caron, Mathilde Mouchiroud, Nicolas Gautier, Sébastien M Labbé, Romain Villot, Laurie Turcotte, Blandine Secco, Guillaume Lamoureux, Michael Shum, Yves Gélinas, André Marette, Denis Richard, David M Sabatini, Mathieu Laplante
OBJECTIVE: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions into distinct protein complexes (mTORC1 and mTORC2) that regulates growth and metabolism. DEP-domain containing mTOR-interacting protein (DEPTOR) is part of these complexes and is known to reduce their activity. Whether DEPTOR loss affects metabolism and organismal growth in vivo has never been tested. METHODS: We have generated a conditional transgenic mouse allowing the tissue-specific deletion of DEPTOR...
May 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28460334/maximal-exhaustive-treadmill-test-features-in-patients-with-temporal-lobe-epilepsy-search-for-sudden-unexpected-death-biomarkers
#16
Guilherme L Fialho, Arthur G Pagani, Roger Walz, Peter Wolf, Katia Lin
Autonomic dysfunction may account for sudden unexpected death in patients with epilepsy (PWE). On the other hand, low cardiovascular fitness, which may affect autonomic function, is a risk factor for sudden death and all-cause mortality in the general population. Little is known about autonomic variables and cardiovascular response to exercise in PWE. We submitted thirty consecutive PWE with no known cardiovascular diseases to maximal treadmill test, comparing them with matched controls. All individuals were submitted to clinical assessment, 12-lead electrocardiogram (ECG) and echocardiogram to exclude cardiovascular disease...
April 24, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28456497/smoking-before-isometric-exercise-amplifies-myocardial-stress-and-dysregulates-baroreceptor-sensitivity-and-cerebral-oxygenation
#17
Panagiota Anyfanti, Eleftheria Triantafyllidou, Stavros Papadopoulos, Areti Triantafyllou, Michalis G Nikolaidis, Antonios Kyparos, Ioannis S Vrabas, Stella Douma, Andreas Zafeiridis, Konstantina Dipla
This crossover study examined whether acute cardiovascular responses, baroreceptor sensitivity (BRS), and brain oxygenation during isometric exercise are altered after cigarette smoking. Twelve young, habitual smokers randomly performed a smoking and a control protocol, during which participants smoked one cigarette (0.9 mg nicotine) or a sham cigarette, before exercise. Testing involved baseline, a 5-minute smoking, a 10-minute post-smoking rest, 3-minute handgrip exercise (30% maximum voluntary contraction), and recovery...
April 14, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28452146/autonomic-testing-for-prediction-of-competition-performance-in-paralympic-athletes
#18
Jordan W Squair, Aaron A Phillips, Katharine D Currie, Cameron Gee, Andrei V Krassioukov
PURPOSE: While we now appreciate that autonomic dysfunction can impact Wheelchair Rugby performance, this is currently not being assessed during classification, largely due to lack of a standardized and evidence-based strategy to assess autonomic function. Our aim, therefore, was to establish the optimal autonomic testing protocol that best predicts cardiovascular capacity during competition by comprehensively examining autonomic function in elite Wheelchair Rugby athletes with cervical SCI and thereby enhance the standardized classification...
April 27, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28451646/chronotropic-incompetence-and-risk-of-atrial-fibrillation-the-henry-ford-exercise-testing-fit-project
#19
Wesley T O'Neal, Waqas T Qureshi, Michael J Blaha, Zeina A Dardari, Jonathan K Ehrman, Clinton A Brawner, Elsayed Z Soliman, Mouaz H Al-Mallah
OBJECTIVES: To examine the association between chronotropic incompetence and incident atrial fibrillation (AF). BACKGROUND: Patients with inadequate heart rate response during exercise may have abnormalities in sinus node function or autonomic tone that predispose to the development of AF. METHODS: We examined the association between heart rate response and incident AF in 57,402 (mean age=54±13 years, 47% female, 64% white) patients free of baseline AF who underwent exercise-treadmill stress testing from the Henry Ford ExercIse Testing (FIT) Project...
November 2016: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28450143/crosstalk-between-nuclear-and-g-protein-coupled-estrogen-receptors
#20
REVIEW
Shannon N Romano, Daniel A Gorelick
In 2005, two groups independently discovered that the G protein-coupled receptor GPR30 binds estradiol in cultured cells and, in response, initiates intracellular signaling cascades Revankar et al. (2005), Thomas et al. (2005). GPR30 is now referred to as GPER, the G-protein coupled estrogen receptor Prossnitz and Arterburn (2015). While studies in animal models are illuminating GPER function, there is controversy as to whether GPER acts as an autonomous estrogen receptor in vivo, or whether GPER interacts with nuclear estrogen receptor signaling pathways in response to estrogens...
April 25, 2017: General and Comparative Endocrinology
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