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https://www.readbyqxmd.com/read/29790404/clinical-and-neurophysiological-changes-after-targeted-intrathecal-injections-of-bone-marrow-stem-cells-in-a-c3-tetraplegic-subject
#1
Andrea Jimena Santamaria, Francisco D Benavides, Darcy L DiFede, Aisha Khan, Marietsy V Pujol, W Dalton Dietrich, Antonio Marttos, Barth A Green, Joshua M Hare, James Guest
High-level quadriplegia is a devastating condition with limited treatment options. Bone marrow derived stem cells (BMSCs) are reported to have immunomodulatory and neurotrophic effects in spinal cord injury (SCI). We report a subject with complete C2 SCI who received 3 anatomically targeted intrathecal infusions of BMSCs under a single-patient expanded access IND. She underwent intensive physical therapy and was followed for over 2 years. At end-point, her AIS grade improved from A to B and she recovered focal pressure touch sensation over several body areas...
May 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29782509/maternal-cardiovascular-and-endothelial-function-from-first-trimester-to-postpartum
#2
Vassiliki Kolovetsiou-Kreiner, Manfred Georg Moertl, Ilona Papousek, Karin Schmid-Zalaudek, Uwe Lang, Dietmar Schlembach, Mila Cervar-Zivkovic, Helmut Karl Lackner
OBJECTIVE: To explore noninvasively the complex interactions of the maternal hemodynamic system throughout pregnancy and the resulting after-effect six weeks postpartum. METHODS: Eighteen women were tested beginning at the 12th week of gestation at six time-points throughout pregnancy and six weeks postpartum. Heart rate, heart rate variability, blood pressure, pulse transit time (PTT), respiration, and baroreceptor sensitivity were analyzed in resting conditions...
2018: PloS One
https://www.readbyqxmd.com/read/29781840/cardiovascular-autonomic-profile-in-women-with-constitutional-hypotension
#3
Giris Jacob, Franca Barbic, Meytal Glago, Franca Dipaola, Alberto Porta, Raffaello Furlan
BACKGROUND: Constitutional hypotension (CHT) is defined as a SBP below 105 mmHg. As autonomic-related symptoms are frequently reported in CHT, these symptoms suggest that the cardiovascular autonomic control is perturbed in individuals with CHT. METHODS: We investigated the autonomic cardiovascular control of 15 women with CHT and 12 women with NBP (SBP >110 mmHg). We monitored BP and ECG for autonomic function test. Supine and head up tilt (HUT) spectral analysis of RR interval and BP variability, baroreflex sensitivity and plasma levels of plasma renin activity and aldosterone were determined...
May 16, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29781516/cardiac-autonomic-modulation-and-long-term-use-of-amiodarone-in-patients-with-chronic-chagasic-cardiopathy
#4
Henriette Elana Fortes Silva, Renan Sandoval de Almeida, Danilo Batista Silveira, Maurício Llaguno, Luiz Antônio Pertili Rodrigues Resende, Valdo José Dias da Silva, Dalmo Correia
BACKGROUND: Patients with chronic Chagas cardiopathy (CCC), which may be associated with cardiac arrhythmias, frequently use amiodarone, an anti-arrhythmic drug that, experimentally, appears to modulate the cardiac autonomic function. OBJECTIVE: The present cross-sectional observational study aimed to evaluate autonomic cardiac modulation in patients with CCC undergoing chronic amiodarone therapy. METHODS: Three groups were investigated: Group 1 included patients with CCC not treated with amiodarone (n = 27); Group 2 included patients with CCC with prolonged use (at least 6 months) of amiodarone (n = 16); and Group 3 including non-chagasic control patients (n = 23)...
May 21, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29778242/cardiovascular-responses-to-isometric-handgrip-exercise-in-young-patients-with-recurrent-vasovagal-syncope
#5
Juan Idiaquez, Juan Francisco Idiaquez, Rodrigo Iturriaga
OBJECTIVE: Arterial blood pressure (BP) increased in healthy humans in response to isometric handgrip (IHG), but the pattern of the relative contribution of cardiac output (CO) and total peripheral resistance (TPR) changes to the pressor response is different among individuals. We investigated weather patients with recurrent vasovagal syncope (VVS) have a similar pattern of individual CO, TPR and pressor responses to IHG, as healthy subjects. METHODS: 32 patients (27...
July 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29778071/anxious-distress-in-depressed-outpatients-prevalence-comorbidity-and-incremental-validity
#6
Anthony J Rosellini, Michelle L Bourgeois, Jeannette Correa, Esther S Tung, Svetlana Goncharenko, Timothy A Brown
The goals of this study were to estimate the prevalence of the DSM-5 anxious distress specifier (AD) among depressed outpatients, to examine associations of AD with comorbid diagnoses, and to test the incremental validity of AD over comorbidity in predicting functional impairment and severity of anxiety and depression symptoms. The sample was 237 outpatients diagnosed with major depressive disorder (MDD) or persistent depressive disorder (PDD), with and without AD, using the Anxiety and Related Disorders Interview Schedule for DSM-5...
May 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29765005/heart-rate-recovery-physical-activity-level-and-functional-status-in-subjects-with-copd
#7
Andrea A Morita, Laís K O Silva, Gianna W Bisca, Joice M Oliveira, Nidia A Hernandes, Fabio Pitta, Karina C Furlanetto
BACKGROUND: A normal heart rate reflects the balance between the sympathetic and parasympathetic autonomic nervous system. When the difference between heart rate at the end of an exercise test and after 1 min of recovery, known as the 1-min heart rate recovery, is ≤ 12 beats/min, this may indicate an abnormal delay. We sought to compare physical activity patterns and subjects' functional status with COPD with or without delayed 1-min heart rate recovery after the 6-min walk test (6MWT)...
May 15, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29757410/chronic-kidney-disease-and-peripheral-nerve-function-in-the-health-aging-and-body-composition-study
#8
Ranjani N Moorthi, Simit Doshi, Linda F Fried, Sharon M Moe, Mark J Sarnak, Suzanne Satterfield, Ann V Schwartz, Michael Shlipak, Brittney S Lange-Maia, Tamara B Harris, Anne B Newman, Elsa S Strotmeyer
Background: Chronic kidney disease (CKD) is associated with poor mobility. Peripheral nerve function alterations play a significant role in low mobility. We tested the hypothesis that early CKD is associated with altered sensory, motor and autonomic nerve function. Methods: Participants in the Health, Aging and Body Composition cohort who had kidney function measures in Year 3 (1999-2000) and nerve function measurements at Year 4 (2000-01) were analyzed (n = 2290)...
May 10, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29753372/the-relations-among-serum-ghrelin-motilin-and-gastric-emptying-and-autonomic-function-in-autoimmune-gastritis
#9
Çağdaş Kalkan, Irfan Soykan
BACKGROUND: Gastric emptying (GE) of solids is delayed and autonomic dysfunction is detected in autoimmune gastritis (AIG). The goals of this study were to: (1) compare serum levels of ghrelin and motilin in subjects with delayed and normal GE and (2) investigate whether circulating antimyenteric antibodies (CAA), serum ghrelin levels and motilin levels have any effect on autonomic function. MATERIALS AND METHODS: Noninvasive cardiovascular reflex tests were used in order to evaluate the autonomic function...
May 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29751603/agent-based-intelligent-interface-for-wheelchair-movement-control
#10
Alberto L Barriuso, Javier Pérez-Marcos, Diego M Jiménez-Bravo, Gabriel Villarrubia González, Juan F De Paz
People who suffer from any kind of motor difficulty face serious complications to autonomously move in their daily lives. However, a growing number research projects which propose different powered wheelchairs control systems are arising. Despite of the interest of the research community in the area, there is no platform that allows an easy integration of various control methods that make use of heterogeneous sensors and computationally demanding algorithms. In this work, an architecture based on virtual organizations of agents is proposed that makes use of a flexible and scalable communication protocol that allows the deployment of embedded agents in computationally limited devices...
May 11, 2018: Sensors
https://www.readbyqxmd.com/read/29745872/effects-of-autonomic-dysfunction-on-exercise-tolerance-in-systemic-sclerosis-patients-without-clinical-and-instrumental-evidence-of-cardiac-and-pulmonary-involvement
#11
Marcello Di Paolo, Antonietta Gigante, Marta Liberatori, Liborio Sardo, Paolo Marinelli, Marco Rossetti, Paolo Palange, Luigi Tubani, Edoardo Rosato
OBJECTIVES: Autonomic dysfunction (AD) in systemic sclerosis (SSc) was already confirmed through heart rate variability (HRV) analysis. Cardio-pulmonary exercise testing (CPET) is a useful tool in early detection of exercise tolerance in SSc patients. Aim of the study was to assess the relationships existing between AD and exercise tolerance. METHODS: Thirty-two [4 M, 28 F; median age: 47.5 (20-65) years] consecutive SSc patients were enrolled. All patients underwent pulmonary function testing, incremental symptom-limited CPET and twenty-four hours ECG Holter recording with HRV analysis in time and frequency domain...
May 4, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29742982/the-nfe2-related-transcription-factor-2-nrf2-coordinates-antioxidant-defense-with-thyroglobulin-production-and-iodination-in-the-thyroid-gland
#12
Panos G Ziros, Ioannis Habeos, Dionysios V Chartoumpekis, Eleni Ntalampyra, Emmanuel Somm, Cédric O Renaud, Massimo Bongiovanni, Ioannis P Trougakos, Masayuki Yamamoto, Thomas W Kensler, Pilar Santisteban, Nancy Carrasco, Carrie Ris-Stalpers, Elena Amendola, Xiao-Hui Liao, Luciano Rossich, Lisa Thomasz, Guillermo Juan Juvenal, Samuel Refetoff, Gerasimos P Sykiotis
BACKGROUND: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation in order to maintain normal function. Although antioxidant and detoxification enzymes presumably aid thyroid cells to maintain homeostasis by ameliorating oxidative insults, including under conditions of exposure to excess iodide, the factors that coordinate their expression with the cellular redox status are not known...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29738572/ciliary-margin-derived-bmp4-does-not-have-a-major-role-in-ocular-development
#13
Rebecca L Rausch, Richard T Libby, Amy E Kiernan
Heterozygous Bmp4 mutations in humans and mice cause severe ocular anterior segment dysgenesis (ASD). Abnormalities include pupil displacement, corneal opacity, iridocorneal adhesions, and variable intraocular pressure, as well as some retinal and vascular defects. It is presently not known what source of BMP4 is responsible for these defects, as BMP4 is expressed in several developing ocular and surrounding tissues. In particular, BMP4 is expressed in the ciliary margins of the optic cup which give rise to anterior segment structures such as the ciliary body and iris, making it a good candidate for the required source of BMP4 for anterior segment development...
2018: PloS One
https://www.readbyqxmd.com/read/29737432/assessment-of-sudomotor-function
#14
REVIEW
Sylvia J Buchmann, Ana Isabel Penzlin, Marie Luise Kubasch, Ben Min-Woo Illigens, Timo Siepmann
PURPOSE: To review the currently available literature on clinical autonomic tests of sudomotor function. METHODS: We searched PubMED/MEDLINE for articles on technical principles and clinical applications of sudomotor tests with a focus on their drawbacks and perspectives in order to provide a narrative review. RESULTS: The quantitative sudomotor axon reflex sweat test (QSART) is the most widely used test of sudomotor function. The technique captures pathology with low intra- and inter-subject variability but is limited by technical demands...
May 8, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29734566/hyperbaric-oxygen-for-post-concussive-symptoms-in-united-states-military-service-members-a-randomized-clinical-trial
#15
Lindell K Weaver, Steffanie H Wilson, Anne S Lindblad, Susan Churchill, Kayla Deru, Robert C Price, Chris S Williams, William W Orrison, James M Walker, Anna Meehan, Susan Mirow
Background: In prior military randomized trials, participants with persistent symptoms after mild traumatic brain injury (TBI) reported improvement regardless of receiving hyperbaric oxygen (HBO₂) or sham intervention. This study's objectives were to identify outcomes for future efficacy trials and describe changes by intervention. Methods: This Phase II, randomized, double-blind, sham-controlled trial enrolled military personnel with mild TBI and persistent post-concussive symptoms...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29731622/chronic-obstructive-pulmonary-disease-severity-and-its-association-with-obstructive-sleep-apnea-syndrome-impact-on-cardiac-autonomic-modulation-and-functional-capacity
#16
Katiany Thays Lopes Zangrando, Renata Trimer, Luiz Carlos Soares de Carvalho, Guilherme Peixoto Tinoco Arêas, Flávia Cristina Rossi Caruso, Ramona Cabiddu, Meliza Goi Roscani, Fabíola Paula Galhardo Rizzatti, Audrey Borghi-Silva
Background: The study was conducted to determine the impact of chronic obstructive pulmonary disease (COPD) in association with obstructive sleep apnea syndrome (OSAS) on cardiac autonomic control and functional capacity. Subjects and methods: The study was a cross-sectional prospective controlled clinical study. Heart rate variability indices of 24 COPD (n = 12) and COPD+OSAS (n = 12) patients were evaluated and compared by electrocardiographic recordings acquired during rest, active postural maneuver (APM), respiratory sinus arrhythmia maneuver (RSA-m), and the 6-minute walk test (6MWT)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29730509/protein-restriction-diet-during-the-suckling-phase-programs-rat-metabolism-against-obesity-and-insulin-resistance-exacerbation-induced-by-a-high-fat-diet-in-adulthood
#17
Isabela Peixoto Martins, Júlio Cezar de Oliveira, Audrei Pavanello, Camila Cristina Ianoni Matiusso, Carina Previate, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Claudinéia Conationi da Silva Franco, Rosiane Aparecida Miranda, Kelly Valério Prates, Vander Silva Alves, Flávio Andrade Francisco, Ana Maria Praxedes de Moraes, Paulo Cezar de Freitas Mathias, Ananda Malta
Protein restriction during the suckling phase can malprogram rat offspring to a lean phenotype associated with metabolic dysfunctions later in life. We tested whether protein-caloric restriction during lactation can exacerbate the effect of a high-fat (HF) diet at adulthood. To test this hypothesis, we fed lactating Wistar dams with a low-protein (LP; 4% protein) diet during the first 2 weeks of lactation or a normal-protein (NP; 23% protein) diet throughout lactation. Rat offspring from NP and LP mothers received a normal-protein diet until 60 days old...
April 3, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29728527/disrupted-hypothalamic-functional-connectivity-in-patients-with-pd-and-autonomic-dysfunction
#18
Eran Dayan, Miriam Sklerov, Nina Browner
OBJECTIVE: To test whether symptoms of autonomic dysfunction in Parkinson disease (PD) are associated with alterations in intrinsic hypothalamic functional connectivity, given the regulatory role of the hypothalamus (HTH) in the autonomic nervous system. METHODS: Resting-state fMRI scans from patients with PD were analyzed, comparing patients with the highest (n = 24) and lowest (n = 28) quartile scores in a questionnaire assessing autonomic dysfunction in PD (Scales for Outcomes in Parkinson's Disease-Autonomic [SCOPA-AUT]), obtained from a larger pool of patients (n = 93)...
May 4, 2018: Neurology
https://www.readbyqxmd.com/read/29720474/functional-and-genomic-characterization-of-a-xenograft-model-system-for-the-study-of-metastasis-in-triple-negative-breast-cancer
#19
Cameron N Johnstone, Andrew D Pattison, Kylie L Gorringe, Paul F Harrison, David R Powell, Peter Lock, David Baloyan, M Ernst, Alastair G Stewart, Traude H Beilharz, Robin L Anderson
Triple-negative breast cancer represents 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to other subtypes. Hence, new molecular targets for therapeutic intervention are necessary. Analyses of panels of human or mouse cancer lines derived from the same individual that differ in their cellular phenotypes but not in genetic background have been instrumental in defining the molecular players that drive the various hallmarks of cancer.To determine the molecular regulators of metastasis in triple-negative breast cancer, we completed a rigorous in vitro and in vivo characterization of four populations of the MDA-MB-231 human breast cancer line ranging in aggressiveness from non-metastatic to spontaneously metastatic to lung, liver, spleen and lymph node...
April 30, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29706494/is-there-a-role-for-genes-in-exercise-induced-atrial-cardiomyopathy
#20
REVIEW
Diane Fatkin, Charles D Cox, Inken G Huttner, Boris Martinac
In endurance athletes, prolonged high intensity exercise participation can have deleterious effects on the myocardium with subsequent structural and electrical remodelling. In a subset of athletes, there is a predilection for atrial involvement and the risk of atrial fibrillation (AF) is increased. The mechanisms underpinning exercise-induced atrial cardiomyopathy have yet to be fully elucidated and the contribution of an individual's genetic makeup is unknown. Some athletes may have rare genetic variants that are sufficient to cause AF irrespective of exercise exposure...
April 9, 2018: Heart, Lung & Circulation
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