Zhaoyi Zhong, Yangting Zhang, Yuan Wei, Xiaona Li, Lisheng Ren, Yan Li, Xueqian Zhang, Chengyu Chen, Xueru Yin, Run Liu, Qiuzhen Wang
Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Fucoidan, a polysaccharide containing fucose and sulfate group, ameliorates DN. However, the underlying mechanism has not been fully understood. This study aimed to explore the effects and mechanism of fucoidan on DN in high-fat diet-induced diabetic mice. A total of 90 C57BL/6J mice were randomly assigned to six groups ( n = 15) as follows: normal control (NC), diabetes mellitus (DM), metformin (MTF), low-dose fucoidan (LFC), medium-dose fucoidan (MFC), and high-dose fucoidan (HFC)...
April 18, 2024: Journal of Agricultural and Food Chemistry