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https://www.readbyqxmd.com/read/29053921/integrated-kidney-exosome-analysis-ikea-for-the-detection-of-kidney-transplant-rejection
#1
Jongmin Park, Hsing-Ying Lin, Jean Pierre Assaker, Sangmoo Jeong, Chen-Han Huang, Ahmed Kurdi, Kyungheon Lee, Kyle Fraser, Changwook Min, Siawosh Eskandari, Sujit Routray, Bakhos A Tannous, Reza Abdi, Leonardo Riella, Anil Chandraker, Cesar M Castro, Ralph Weissleder, Hakho Lee, Jamil R Azzi
Kidney transplant patients require life-long surveillance to detect allograft rejection. Repeated biopsy, albeit the clinical gold standard, is an invasive procedure with the risk of complications and comparatively high cost. Conversely, serum creatinine or urinary proteins are non-invasive alternatives, but are late markers with low specificity. We here report a new urine-based platform to detect kidney transplant rejection. Termed iKEA (integrated kidney exosome analysis), the approach detects extracellular vesicles (EVs) released by immune cells into urine; we reasoned that T cells, attacking kidney allografts, would shed EVs, which in turn can be used as surrogate marker for inflammation...
October 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29053816/histomorphometric-study-of-the-anterior-latissimus-dorsi-muscle-and-evaluation-of-enzymatic-markers-of-broilers-affected-with-dorsal-cranial-myopathy
#2
R Sesterhenn, F M Siqueira, A C Hamerski, D Driemeier, S F Valle, S L Vieira, L Kindlein, V P Nascimento
Dorsal cranial myopathy (DCM), which affects the anterior latissimus dorsi (ALD) muscles of commercial broilers, is of unknown etiology, and it represents up to 6% of the partial condemnations in Brazilian slaughterhouses. This study was performed to achieve histomorphometric characterizations of the ALD muscles from male Cobb 500 broilers slaughtered at either 35 d or 42 d and to evaluate the effects of DCM on the enzymatic markers aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), and lactate dehydrogenase (LDH) and on uric acid and creatinine metabolites...
September 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053718/optical-coherence-tomography-angiography-vessel-density-in-children-with-type-1-diabetes
#3
Joanna Gołębiewska, Andrzej Olechowski, Marta Wysocka-Mincewicz, Dominik Odrobina, Marta Baszyńska-Wilk, Artur Groszek, Mieczysław Szalecki, Wojciech Hautz
PURPOSE: To assess the optical coherence tomography angiography (OCTA) retinal vessel density and foveal avascular zone (FAZ) in children with type 1 diabetes (T1D) and compare potential pathologic early changes in this population to healthy age-matched controls. METHODS: This study included 130 pubescent children: 94 with T1D (188 eyes) and 36 of their age-matched control group (60 eyes). OCTA was performed using AngioVue (Avanti, Optivue). FAZ area (mm2) in superficial plexus, whole superficial capillary vessel density (wsVD), fovea superficial vessel density (fsVD), parafovea superficial vessel density (psVD), whole deep vessel density (wdVD), fovea deep vessel density (fdVD), parafovea deep vessel density (pdVD), foveal thickness (FT) (μm) and parafoveal thickness (PFT) (μm) were taken into analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29053168/fl-926-16-a-novel-bioavailable-carnosinase-resistant-carnosine-derivative-prevents-onset-and-stops-progression-of-diabetic-nephropathy-in-db-db-mice
#4
Carla Iacobini, Stefano Menini, Claudia Blasetti Fantauzzi, Carlo M Pesce, Andrea Giaccari, Enrica Salomone, Annunziata Lapolla, Marica Orioli, Giancarlo Aldini, Giuseppe Pugliese
BACKGROUND AND PURPOSE: The advanced glycation endproducts (AGEs) participate in the pathogenesis of diabetic nephropathy (DN) by promoting renal inflammation and injury. L-carnosine acts as a quencher of the AGE precursors reactive carbonyl species (RCS), but it is rapidly inactivated by carnosinase. This study evaluated the effect of FL-926-16, a carnosinase-resistant and bioavailable carnosine derivative, on the onset and progression of DN in db/db mice. EXPERIMENTAL APPROACH: Adult male db/db mice and coeval db/m controls were left untreated or treated with FL-926-16 (30 mg·kg(-1) body weight) from week 6 to 20 (prevention protocol) or from week 20 to 34 (regression protocol)...
October 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29052906/evaluation-of-adherence-and-tolerability-of-prolonged-release-tacrolimus-advagraf-%C3%A2-in-kidney-transplant-patients-in-germany-a-multicenter-non-interventional-study
#5
Lukas J Lehner, Petra Reinke, Jan Hörstrup, Thomas Rath, Barbara Suwelack, Bernhard K Krämer, Klemens Budde, Bernhard Banas
This study assessed adherence to prolonged-release tacrolimus (PR-T)-based immunosuppression during routine maintenance of renal transplant recipients in Germany. Patients had received PR-T for ≥1 month at inclusion. Data were collected during four visits (V): baseline (V1), 6 (V2), 12 (V3) and 18 (V4) months. Composite primary endpoint: non-adherence at V4, defined as self-reported non-adherence on the Basel Assessment of Adherence with Immunosuppressive Medication Scale (BAASIS©), investigator-rated non-adherence, and/or V4 tacrolimus trough level outside a pre-defined range...
October 20, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29052786/tolvaptan-promotes-urinary-excretion-of-sodium-and-urea-a-retrospective-cohort-study
#6
Satoshi Minami, Takayuki Hamano, Hirotsugu Iwatani, Masayuki Mizui, Yoshiki Kimura, Yoshitaka Isaka
BACKGROUND: Tolvaptan (TLV) promotes aquaresis; however, little is known about its effect on solute excretion in chronic kidney disease (CKD). METHODS: We retrospectively studied CKD patients with decompensated heart failure (HF) or those with autosomal dominant polycystic kidney disease (ADPKD) receiving TLV. Patients with an increased urine volume of more than twice of daily variance were defined as "responders" in HF. We compared the ability of the urinary osmolality (U-OSM) change and urinary creatinine concentration ([U-Cr]) change to discriminate "responders"...
October 20, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29052559/efficacy-and-safety-of-niaoduqing-particles-for-delaying-moderate-to-severe-renal-dysfunction-a-randomized-double-blind-placebo-controlled-multicenter-clinical-study
#7
Ying Zheng, Guang-Yan Cai, Li-Qun He, Hong-Li Lin, Xiao-Hong Cheng, Nian-Song Wang, Gui-Hua Jian, Xu-Sheng Liu, Yu-Ning Liu, Zhao-Hui Ni, Jing-Ai Fang, Han-Lu Ding, Wang Guo, Ya-Ni He, Li-Hua Wang, Ya-Ping Wang, Hong-Tao Yang, Zhi-Ming Ye, Ren-Huan Yu, Li-Juan Zhao, Wen-Hua Zhou, Wen-Ge Li, Hui-Juan Mao, Yong-Li Zhan, Zhao Hu, Chen Yao, Ri-Bao Wei, Xiang-Mei Chen
BACKGROUND: Chronic kidney disease (CKD) with moderate-to-severe renal dysfunction usually exhibits an irreversible course, and available treatments for delaying the progression to end-stage renal disease are limited. This study aimed to assess the efficacy and safety of the traditional Chinese medicine, Niaoduqing particles, for delaying renal dysfunction in patients with stage 3b-4 CKD. METHODS: The present study was a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29052087/does-green-tea-consumption-increase-urinary-oxalate-excretion-results-of-a-prospective-trial-in-healthy-men
#8
Kang Chen, Dong Chen, Chuangxin Lan, Xiongfa Liang, Tao Zeng, Jian Huang, Xiaolu Duan, Zhenzhen Kong, Shujue Li, Hans-Göran Tiselius, Alberto Gurioli, Xiaogang Lu, Guohua Zeng, Wenqi Wu
OBJECTIVE: To investigate the impact of green tea on urinary oxalate excretion in healthy male volunteers. MATERIALS AND METHODS: The oxalate concentrations after different brewing times (2-60 min) of different qualities (2-8 g) of green tea were measured in in vitro experiment. In in vivo experiment, the effects on urine composition were assessed in 12 healthy men with an age of 24-29 years. Each subject was requested to collect two 24-h urine samples under normal dietary conditions...
October 19, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29052086/tissue-and-urinary-kim-1-relate-to-tumor-characteristics-in-patients-with-clear-renal-cell-carcinoma
#9
Mirjana Mijuskovic, Ivan Stanojevic, Novak Milovic, Snezana Cerovic, Dejan Petrovic, Djoko Maksic, Bozidar Kovacevic, Tamara Andjelic, Predrag Aleksic, Brankica Terzic, Mirjana Djukic, Danilo Vojvodic
The objective of this prospective follow-up trial was to ascertain whether the urinary kidney injury molecule-1 (uKIM-1) associates with tumor tissue (tKIM-1) expression and with the pathological characteristics of clear renal cell carcinoma (cRCC) in radically nephrectomized (RN) and/or in partially nephrectomized (PN) patients with cRCC, pre- and postoperatively. This clinical study included 40 patients subjected to RN/PN (cRCC group) and 30 healthy volunteers (control group). Urinary KIM-1 was determined by ELISA TIM-1/KIM-1 kit and normalized by urinary creatinine...
October 19, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29051476/independent-factors-predicting-postoperative-30-day-mortality-in-101-infants-following-liver-transplantation
#10
Chan Woo Cho, Sanghoon Lee, Jong Man Kim, Gyu-Seong Choi, Choon Hyuck David Kwon, Jae-Won Joh, Suk-Koo Lee
BACKGROUND Liver transplantation (LT) in infants is a challenging procedure. This study was designed to identify risk factors of 30-day mortality of infant LT recipients. MATERIAL AND METHODS A total of 101 infants treated between May 1997 and March 2015 were assigned to one of two groups, a deceased infant group (n=9) or a live infant group (n=92), according to their mortality status at 30 days after LT. RESULTS Patient characteristics of height, weight, preoperative total bilirubin, creatinine clearance, primary diagnosis, and graft-to-recipient weight ratio (GRWR) were significantly different between the two groups...
October 20, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29051443/vitis-vinifera-extract-ameliorate-hepatic-and-renal-dysfunction-induced-by-dexamethasone-in-albino-rats
#11
Nabil A Hasona, Ahmed A Alrashidi, Thamer Z Aldugieman, Ali M Alshdokhi, Mohammed Q Ahmed
This study was conducted to evaluate the biochemical effects of grape seed extract against dexamethasone-induced hepatic and renal dysfunction in a female albino rat. Twenty-eight adult female rats were divided randomly into four equal groups: Group 1: animals were injected subcutaneously with saline and consider as normal control one. Group 2: animals were injected subcutaneously with dexamethasone in a dose of 0.1 mg/kg body weight. Group 3: animals were injected subcutaneously with 0.1 mg/kg body weight of dexamethasone, and then treated with a grape seed extract in a dose of 200 mg/kg body weight by oral gavage...
April 11, 2017: Toxics
https://www.readbyqxmd.com/read/29051435/urinary-naphthol-as-a-biomarker-of-exposure-results-from-an-oral-exposure-to-carbaryl-and-workers-occupationally-exposed-to-naphthalene
#12
Craig Sams
Urinary naphthol is an established human biomarker used for assessing both occupational and environmental exposure. However, 1-naphthol is a metabolite of the insecticide carbaryl while both the 1- and 2-isomers are metabolites of naphthalene. Thus, urinary 1-naphthol levels will reflect combined exposure to both substances, particularly at environmental levels. The interpretation of biomarkers is aided by knowledge of levels following well-characterised exposure scenarios. This study reports urinary 1-naphthol levels in five volunteers administered an oral dose of carbaryl at the acceptable daily intake (ADI, 0...
January 6, 2017: Toxics
https://www.readbyqxmd.com/read/29051431/haematological-biochemical-and-antioxidant-changes-in-wistar-rats-exposed-to-dichlorvos-based-insecticide-formulation-used-in-southeast-nigeria
#13
Kingsley C Kanu, Solomon N Ijioma, Odudu Atiata
The indiscriminate use of pesticide is a treat to non-target organisms. This study evaluates the haematological and biochemical changes induced by inhalation of local Nigerian dichlorvos insecticide on rats. The rats were randomly assigned to a control group which received only food and water and a test group which, in addition to food and water, was exposed to the pesticide for a period of 4 h daily for 28 days, after which exposure was discontinued for seven days. Five animals were sacrificed from each group on days 1, 7, 14, 21, 28 and 35, and blood was collected by cardiac puncture for haematological, biochemical and antioxidant analysis...
November 29, 2016: Toxics
https://www.readbyqxmd.com/read/29051307/effect-of-renal-denervation-on-urine-angiotensinogen-excretion-in-prenatally-programmed-rats
#14
Asifhusen Mansuri, Susan K Legan, Jyoti Jain, Issa Alhamoud, Jyothsna Gattineni, Michel Baum
Prenatal programming results in an increase in blood pressure in adult offspring. We have shown that compared to control adult offspring whose mothers were fed a 20% protein diet, programmed adults whose mothers were fed a 6% protein diet during the last half of pregnancy have an increase in renal sympathetic nerve activity and urinary angiotensinogen/creatinine levels. We hypothesized that the increase in urinary angiotensinogen was mediated by renal sympathetic nerve activity in programmed rats. In this study performed in 3 month old rats, renal denervation resulted in normalization of blood pressure in the 6% programmed group (150 ± 3 Hg in 6% sham vs...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29051146/apol1-risk-variants-incident-proteinuria-and-subsequent-egfr-decline-in-blacks-with-hypertension-attributed-ckd
#15
Teresa K Chen, Adrienne Tin, Carmen A Peralta, Lawrence J Appel, Michael J Choi, Michael S Lipkowitz, Cheryl A Winkler, Michelle M Estrella
BACKGROUND AND OBJECTIVES: The natural history of kidney disease among blacks who carry the APOL1 high-risk variants varies, with only a subgroup progressing to ESRD. We aimed to determine whether the APOL1 risk variants are associated with incident proteinuria in the context of hypertension-attributed CKD, and whether subsequent kidney function decline after the onset of proteinuria differs by APOL1 risk status. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using Cox models, we studied the association between APOL1 risk status and incident proteinuria (defined as a doubling of urine protein-to-creatinine ratio to a level ≥0...
October 19, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29051143/health-care-costs-associated-with-aki
#16
David Collister, Neesh Pannu, Feng Ye, Matthew James, Brenda Hemmelgarn, Betty Chui, Braden Manns, Scott Klarenbach
BACKGROUND AND OBJECTIVES: An understanding of the health care resource use associated with AKI is needed to frame the investment and cost-effectiveness of strategies to prevent AKI and promote kidney recovery. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We assembled population-based cohort of adults hospitalized in Alberta between November of 2002 and March of 2009 without ESRD or an eGFR<15 ml/min per 1.73 m(2). Outpatient serum creatinine measurements 6 months preceding admission defined baseline kidney function, and serum creatinine during the first 14 days of hospitalization defined Acute Kidney Injury Network stage; kidney recovery defined as serum creatinine within 25% of baseline and independence from dialysis was assessed at 90 days after AKI...
October 19, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29051111/perspectives-on-using-a-multiplex-human-kidney-safety-biomarker-panel-to-detect-cisplatin-induced-tubular-toxicity-in-male-and-female-cynomolgus-monkeys
#17
Yafei Chen, J Dale Thurman, Lewis B Kinter, Russell Bialecki, J Eric McDuffie
Multiplex biomarker panel assays would enable early de-risking of discovery compound related kidney safety liabilities. The objective of this study was to evaluate the usefulness of the Myriad RBM Human KidneyMAP (Multi-Analyte Profile)® v.1.0 panel to detect experimental nephrotoxicity in Cynomolgus monkeys following a single intravenous administration of cisplatin (2.5mg/kg). Urine samples were collected at baseline on day -2; at approximately 4hr post-dose on day 1; and on days 4, 9, 15 and/or 20. Blood samples were collected at predose on day -2; at 4hr post-dose on day 1; and on days 2, 5, 10 and/or 21...
October 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29051004/assessing-time-of-full-renal-recovery-following-minimally-invasive-partial-nephrectomy
#18
Mark T Dawidek, Ernest Chan, Shawna L Boyle, Alp Sener, Patrick P Luke
OBJECTIVE: To assess renal function in the operated kidney at different time points post partial nephrectomy (PN) and establish the time in which optimal recovery occurs. Recovery of renal function post-PN has received significant attention. However, the optimal time to determine full recovery has not been clearly established. METHODS: Renal function following minimally invasive (laparoscopic and robotic) PNs performed between 2002 and 2015 was reviewed. Patients included in this study had renal function assessed pre-operatively as well as 3 days, 6-12 weeks, and 1 year post-PN, using a combination of estimated glomerular filtration rate (eGFR) from serum creatinine and relative renal uptake (RRU) from Tc99m-MAG3 renal scintigraphy...
October 16, 2017: Urology
https://www.readbyqxmd.com/read/29050721/acute-kidney-injury-secondary-to-cell-saver-in-posterior-spinal-fusion
#19
Anas A Minkara, Albert Y Lin, Michael G Vitale, David P Roye
BACKGROUND: Autologous blood transfusion, commonly referred to as cell saver, is frequently used in spinal fusion to salvage red blood cells because of the risk of significant intraoperative blood loss. This case report describes a case of acute kidney injury (AKI) secondary to cell saver use. Our objective is to increase the knowledge about the process of red blood cell salvage and this exceedingly rare complication. METHODS: Chart and renal biopsy results for a single case were reviewed and reported in this retrospective study...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29050702/relationship-between-a-fragmented-qrs-and-microalbuminuria-in-patients-with-type-2-diabetes-mellitus
#20
Sukru Cetin, Suleyman Sezai Yıldız, Emrah Erkan Mazı, Kudret Keskin, Gokhan Cetinkal, Ahmet Gurdal, Umut Karabay, Kadriye Orta Kilickesmez
INTRODUCTION: Microalbuminuria (MAU), a complication of diabetes, is closely related to cardiovascular events. A fragmented QRS (fQRS) in the electrocardiogram (ECG) was found to be strongly associated to cardiovascular morbidity and mortality. OBJECTIVE: The aim of this study was to assess the association between a fQRS and MAU in patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: One hundred and twenty-seven patients (mean age, 50...
November 2017: Endocrinología, diabetes y nutrición
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