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https://www.readbyqxmd.com/read/29241180/high-mobility-group-box1-inhibitor-glycyrrhizic-acid-attenuates-kidney-injury-in-streptozotocin-induced-diabetic-rats
#1
Hong Zhang, Ru Zhang, Juan Chen, Min Shi, Wei Li, Xiangcheng Zhang
BACKGROUND/AIMS: High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and mechanisms of an HMGB1 inhibitor, glycyrrhizic acid (GA), in renal injury with the streptozotocin (STZ)-induced rat model. METHODS: The diabetic rat was generated by intraperitoneal injection of STZ and then treated with the HMGB1 inhibitor GA or saline for 8 weeks...
November 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29240802/systemic-factors-related-to-soluble-pro-renin-receptor-in-plasma-of-patients-with-proliferative-diabetic-retinopathy
#2
Keitaro Hase, Atsuhiro Kanda, Ikuyo Hirose, Kousuke Noda, Susumu Ishida
(Pro)renin receptor [(P)RR], a new component of the tissue renin-angiotensin system (RAS), plays a crucial role in inflammation and angiogenesis in the eye, thus contributing to the development of proliferative diabetic retinopathy (PDR). In this study, we investigated systemic factors related to plasma levels of soluble form of (P)RR [s(P)RR] in patients with PDR. Twenty type II diabetic patients with PDR and 20 age-matched, non-diabetic patients with idiopathic macular diseases were enrolled, and plasma levels of various molecules were measured by enzyme-linked immunosorbent assays...
2017: PloS One
https://www.readbyqxmd.com/read/29240709/prevalence-of-albuminuria-in-children-living-in-a-rural-agricultural-and-fishing-subsistence-community-in-lake-chapala-mexico
#3
Felipe Lozano-Kasten, Erick Sierra-Diaz, Alfredo de Jesus Celis-de la Rosa, María Margarita Soto Gutiérrez, Alejandro Aarón Peregrina Lucano
The occurrence of Chronic Kidney Disease (CKD) of unknown etiology in autochthonous child populations residing along the Lake Chapala lakeshore is endemic (Jalisco, México). The objective of this study was to determine the prevalence of albuminuria in the pediatric population and to measure the glomerular filtration rate in children with two positive albuminuria tests. Urinary albumin was measured in 394 children. Subjects with two or more positive albuminuria test donated blood samples for the determination of serum biomarkers...
December 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29240673/urinary-fractional-excretion-of-phosphorus-in-dogs-with-spontaneous-chronic-kidney-disease
#4
Cínthia Ribas Martorelli, Márcia Mery Kogika, Fernanda Chicharo Chacar, Douglas Segalla Caragelasco, Ana Carolina Brandão de Campos Fonseca Pinto, Carla Aparecida Batista Lorigados, Lúcia Conceição Andrade
The increase of urinary fractional excretion of phosphorus (uFEP) may indicate phosphorus retention before the onset of hyperphosphatemia in the early stages of chronic kidney disease (CKD). The hypothesis of this study is whether uFEP may increase during the early stage of CKD as a compensatory mechanism to prevent hyperphosphatemia as well as whether hyperphosphatemia in the late stages is associated with increase or decrease in uFEP in dogs with naturally occurring CKD; therefore, the aim of this study was to determine the uFEP in CKD dogs with different stages...
December 14, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29240565/platelets-to-lymphocyte-ratio-is-a-good-predictor-of-liver-fibrosis-and-insulin-resistance-in-hepatitis-c-virus-related-liver-disease
#5
Ayman Alsebaey, Mostafa Elhelbawy, Imam Waked
BACKGROUND: Hepatitis C virus (HCV) is a global health problem that is complicated by liver fibrosis and insulin resistance (IR). AIM: The aim of this study was to validate neutrophils-to-lymphocytes ratio (NLR) and platelets-to-lymphocytes ratio (PLR) as indirect biomarkers of liver fibrosis and IR in HCV patients. PATIENTS AND METHODS: One hundred and fifty patients were enrolled. Physical examination, BMI, liver function tests, serum creatinine, complete blood count, serum HCV RNA count by PCR, and abdominal ultrasonography were performed...
December 13, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29240010/well-preserved-renal-function-in-children-with-untreated-chronic-liver-disease
#6
Ulla B Berg, Antal Németh
OBJECTIVES: Based on studies with hepatorenal syndrome, it is widely regarded that renal function is impacted in chronic liver disease. Therefore we investigated renal function in our children with chronic liver disease. METHODS: In a retrospective study of 277 children with chronic liver disease, renal function was investigated as glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), measured as clearance of inulin and para-amino hippuric acid or clearance of iohexol...
December 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29239217/effects-of-occupational-exposure-to-aluminium-on-some-oxidative-stress-and-dna-damage-parameters
#7
A M Samir, L A Rashed
AIM: The aim of this work was to investigate the relationships between aluminium levels, oxidative status and DNA damage in workers occupationally exposed to aluminium. SUBJECTS AND METHODS: This study was conducted in a secondary aluminium smelter. It included 96 male workers occupationally exposed to aluminium fume and dust compared to 96 male nonexposed individuals. Full history and clinical examination were done for all participants. Laboratory investigations in the form of serum aluminium, total antioxidant capacity (TAC), urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and comet assay test were performed...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29239058/maternal-alcohol-consumption-during-pregnancy-and-its-association-with-offspring-renal-function-at-30-years-observation-from-a-birth-cohort-study
#8
Sumon Kumar Das, Harold David McIntyre, Rosa Alati, Abdullah Al Mamun
AIM: Prenatal exposure to alcohol has adverse ramifications on foetal development resulting in developmental abnormalities and major congenital anomalies. Experimental studies have documented effects on kidney structure and function among offspring exposed to alcohol during foetal life; however, human evidence is scarce. Thus, the present study aimed to determine the development of CKD among a cohort of 30-year-old Australian offspring whose mothers reported consumption of alcohol during pregnancy...
December 14, 2017: Nephrology
https://www.readbyqxmd.com/read/29239056/association-of-body-mass-index-and-weight-gain-patterns-with-albumin-excretion-in-pregnancy
#9
Özlem B Tulmaç, Zeynep Ö Dağ, Funda Erdoğan, Cemile D Sayan, Nevin Sağsöz
AIM: We examined body mass index (BMI) and gestational weight gain (GWG) patterns of pregnant women and investigated the impact of these factors on the urinary albumin-creatinine ratio (ACR) during pregnancy. METHODS: The data of 163 women whose basal BMI and ACR were measured during the first trimester were used in this study. Body weight alone between 12-16 weeks and body weight together with ACR after 37 weeks of gestation were measured. RESULTS: Overall, 46% of women were overweight or obese, 60...
December 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29238962/population-pharmacokinetics-of-polymyxin-b
#10
Pooja Manchandani, Visanu Thamlikitkul, Yanina Dubrovskaya, Jessica T Babic, David C Lye, Lawrence S Lee, Vincent H Tam
Polymyxin B is used as a last treatment resort for multidrug-resistant Gram-negative bacterial infections. The objectives of this study were to examine the population pharmacokinetics of polymyxin B and investigate factor(s) influencing pharmacokinetic variability. Four serial blood samples each were collected from 35 adult patients at steady state. The concentrations of individual polymyxin B components were analyzed using a validated LCMS/MS assay and combined to derive total concentrations. A maximum likelihood expectation maximization approach was used to fit the data...
December 14, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29238727/glycyrrhizic-acid-prevents-diabetic-nephropathy-by-activating-ampk-sirt1-pgc-1%C3%AE-signaling-in-db-db-mice
#11
Shaozhang Hou, Ting Zhang, Yuan Li, Fengying Guo, Xiu Jin
Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD). Glycyrrhizic acid (GA) is an effective inhibitor of reactive oxygen species (ROS) production. We investigated the role of GA in the progression of renal injury in DN. Albumin (Alb)/creatinine (crea) levels were significantly lower, and renal histopathology was attenuated in the diabetic db/db mice that were treated with GA (15 mg/kg via intraperitoneal injection) once per day for eight weeks. These changes were associated with significantly lower levels of α-smooth muscle actin (α-SMA) and transforming growth factor β1 (TGF-β1) expression...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29238603/early-proteinuria-response-a-valid-real-life-situation-predictor-of-long-term-lupus-renal-outcome-in-an-ethnically-diverse-group-with-severe-biopsy-proven-nephritis
#12
Michelle R Ugolini-Lopes, Luciana Parente C Seguro, Maitê Xavier F Castro, Danielle Daffre, Alex C Lopes, Eduardo F Borba, Eloisa Bonfá
Objective: Two recent important lupus nephritis trials reported that proteinuria was a good predictor of renal outcome in Caucasians, but data on real-life situation, other races and severe nephritis are lacking to substantiate this finding as a simple test to guide clinical practice. The aim of this study was to validate proteinuria as a predictor of long-term renal outcome in real-life situation in a racially diverse group of patients with severe nephritis. Methods: Proteinuria, serum creatinine (SCr) and urine red blood cells were assessed at baseline and after 3, 6 and 12 months, as early predictors of long-term renal outcome (SCr <1...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29238432/renal-function-during-an-open-label-prospective-observational-trial-of-sitagliptin-in-patients-with-diabetes-a-sub-analysis-of-the-jamp-study
#13
Osamu Tomonaga, Hiroshi Sakura, Naotake Hashimoto, Kazuo Sasamoto, Hiroshi Ohashi, Sumiko Hasumi, Noriko Ujihara, Tadasu Kasahara, Hideo Nunome, Masashi Honda, Yasuhiko Iwamoto
Background: The aim of the study was to determine the effects of sitagliptin on renal function in a diabetic population including patients with normal renal function. Methods: We analyzed the association between 12-month, 50 mg/day sitagliptin and renal function in outpatients with type 2 diabetes mellitus and poor blood glucose control in a subset of patients in the larger Januvia Multicenter Prospective Trial in Type 2 Diabetes observational study. Stratified analyses of changes in estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) were performed...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29238166/cardiovascular-liver-and-renal-toxicity-associated-with-an-intravenous-ferric-carboxymaltose-similar-versus-the-originator-compound
#14
Jorge E Toblli, Gabriel Cao, Luis Rico, Margarita Angerosa
Background: Ferric carboxymaltose (FCM) is a stable, non-dextran-based intravenous iron complex used to treat iron deficiency of various etiologies. As FCM is a nonbiological complex drug and cannot be fully characterized by physicochemical analyses, it is important to demonstrate in nonclinical models that FCM similars (FCMS) have similar biodistribution. Materials and methods: A total of 30 nonanemic rats were treated weekly with 40 mg iron/kg body weight intravenous FCM, FCMS, or isotonic saline (controls) for 4 weeks...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29237422/mdrd-vs-ckd-epi-in-comparison-to-51chromium-edta-a-cross-sectional-study-of-malaysian-ckd-cohort
#15
Maisarah Jalalonmuhali, Soo Kun Lim, Mohammad Nazri Md Shah, Kok Peng Ng
BACKGROUND: Accurate measurement of renal function is important: however, radiolabelled gold standard measurement of GFR is highly expensive and can only be used on a very limited scale. We aim to compare the performance of Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations in the multi-ethnic population attending University Malaya Medical Centre (UMMC). METHODS: This is a cross-sectional study recruiting patients, who attend UMMC Nephrology clinics on voluntary basis...
December 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29237417/red-cell-distribution-width-associated-with-adverse-cardiovascular-outcomes-in-patients-with-chronic-kidney-disease
#16
Yueh-An Lu, Pei-Chun Fan, Cheng-Chia Lee, Victor Chien-Chia Wu, Ya-Chung Tian, Chih-Wei Yang, Yung-Chang Chen, Chih-Hsiang Chang
BACKGROUND: Recent studies have demonstrated that red cell distribution width (RDW) is associated with cardiovascular (CV) events and mortality. Patients with chronic kidney disease (CKD) are often anemic and have high RDW levels. In this study, we investigated the effect of RDW on major composite CV outcomes among patients with CKD. METHODS: We retrospectively analyzed patients with CKD who were admitted to the department of cardiology of a tertiary hospital in 2011...
December 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29237046/exposure-to-contrast-media-in-the-perioperative-period-confers-no-additional-risk-of-acute-kidney-injury-in-surgical-patients
#17
Ian Zealley, Huan Wang, Peter T Donnan, Samira Bell
Background: Iodinated contrast media (CM) used in angiography and computed tomography (CT) scans is an important cause of acute kidney injury (AKI) in hospitalized patients undergoing surgery. Contrast-induced nephropathy leads to AKI soon after CM administration. The aim of the study was to determine whether the timing of contrast media exposure related to diagnostic imaging during the immediate perioperative period influences the risk of post-operative AKI. Methods: All patients aged 18 years or above who underwent diagnostic imaging within 7 days of non-cardiac surgery between 1 January 2003 and 31 December 2013 in the Tayside region of Scotland, UK were included in the analysis...
December 9, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29236997/impact-of-fire-suit-ensembles-on-firefighter-pah-exposures-as-assessed-by-skin-deposition-and-urinary-biomarkers
#18
Håkan Wingfors, Jenny Rattfelt Nyholm, Roger Magnusson, Cecilia Hammar Wijkmark
Over the past 10 years, a number of safety measures for reducing firefighters' exposure to combustion particles have been introduced in Sweden. The most important measure was the reduction in the time firefighters wear suits and handle contaminated equipment after turn-outs involving smoke diving. This study was divided into two parts, those being to investigate the level of protection obtained by multiple garment layers and to assess exposure during a standardized smoke diving exercise. First, realistic work protection factors (WPFs) were calculated by comparing air concentrations of the full suite of gaseous and particle-bound polycyclic aromatic hydrocarbons (PAHs) inside and outside structural ensembles, including jacket and thick base layer, during a tough fire extinguishing exercise using wood as the fuel...
December 10, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29236674/citrullus-colocynthis-linn-fruit-extract-ameliorates-cisplatin-induced-hepato-renal-toxicity-in-rats
#19
Olufunmilayo O Adeyemi, Ismail O Ishola, Ifeoluwa D Ajani
Background Cisplatin-induced acute liver and kidney injuries are serious problems in cancer patients during treatment of solid tumours. Objective This study sought to investigate possible protective effect of ethanolic fruit extract of Citrullus colocynthis (CC) against cisplatin-induced hepato-renal toxicity in rats. Methods Thirty male albino rats (150-200 g) were divided into five groups (n=6) and treated as follows: group 1: vehicle (10 mL/kg, p.o.; normal control); group 2: vehicle (10 mL/kg); groups 3-5: CC (100, 200 or 400 mg/kg, p...
December 13, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29236656/secondary-syphilis-associated-with-membranous-nephropathy-and-acute-hepatitis-in-a-patient-with-hiv-a-case-report
#20
Zhou Zhang, Aviv Hever, Nitin Bhasin, Dean A Kujubu
INTRODUCTION: We present a case of membranous nephropathy associated with a secondary syphilis infection in a patient with HIV. CASE PRESENTATION: A 37-year-old white man with HIV who was receiving highly active antiretroviral therapy presented to the Emergency Department with 6 weeks of rectal pain. He had a CD3-CD4 count of 656 cells/mm3 and an undetectable viral load. On admission, he was found to have an anal ulcer, a serum creatinine of 1.4 mg/dL (baseline 0...
2017: Permanente Journal
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