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Immune globulin

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https://www.readbyqxmd.com/read/29776608/development-of-a-polyclonal-anti-dugong-immunoglobulin-g-igg-antibody-with-evaluation-of-total-plasma-igg-in-a-living-dugong-dugong-dugon-population
#1
Arthur Wong, Janet M Lanyon, Sara J McKee, Richard Linedale, Lucy Woolford, Trevor Long, Graham R Leggatt
Species-specific antibodies (Ab) for the measurement of immunoglobulins (Ig) are valuable tools for determining the humoral immune status of threatened and endangered wildlife species such as dugongs. However, no studies have reported antibody reagents against dugong immunoglobulin. The object of this study was to develop an Ab with specificity for dugong IgG and apply this tool to survey total IgG levels in plasma samples from a live wild population of dugongs in southern Queensland, Australia. Dugong IgG was isolated from plasma by protein A/G column chromatography and a polyclonal antiserum was successfully raised against the dugong IgG through immunization of mice...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29774984/comments-on-recent-reports-on-infrared-spectral-detection-of-disease-markers-in-blood-components
#2
Max Diem
The search for disease markers in whole blood, or easily accessible blood components by spectral methods is a highly important aspect in the field of biophotonic research for disease diagnostics and screening, since it promises a minimally invasive approach to assess an individual's state of health. Fourier transform infrared spectroscopy, in particular, promises to be a fast, inexpensive method to search for markers of disease, since it detects variation in the proteome, lipidome and metabolome of biofluids, or activation of immune cells...
May 18, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29742565/current-challenges-and-opportunities-in-the-management-of-antibody-mediated-rejection-in-lung-transplantation
#3
Amanda L Hulbert, Elizabeth N Pavlisko, Scott M Palmer
PURPOSE OF REVIEW: There is increasing recognition of the importance of antibody-mediated rejection (AMR) after lung transplantation. The development of donor-specific antibodies, a key feature of AMR, occurs in approximately 30% of lung transplant recipients and is associated with poor posttransplant outcomes. This review highlights recently developed AMR diagnostic criteria in lung transplantation, potential mechanisms that mediate the development of AMR, and discusses current and emerging treatment strategies for this significant, graft-limiting complication...
June 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29740426/multipotent-adult-progenitor-cells-suppress-t-cell-activation-in-in-vivo-models-of-homeostatic-proliferation-in-a-prostaglandin-e2-dependent-manner
#4
Fiona Carty, Jennifer M Corbett, João Paulo M C M Cunha, James L Reading, Timothy I M Tree, Anthony E Ting, Samantha R Stubblefield, Karen English
Lymphodepletion strategies are used in the setting of transplantation (including bone marrow, hematopoietic cell, and solid organ) to create space or to prevent allograft rejection and graft versus host disease. Following lymphodepletion, there is an excess of IL-7 available, and T cells that escape depletion respond to this cytokine undergoing accelerated proliferation. Moreover, this environment promotes the skew of T cells to a Th1 pro-inflammatory phenotype. Existing immunosuppressive regimens fail to control this homeostatic proliferative (HP) response, and thus the development of strategies to successfully control HP while sparing T cell reconstitution (providing a functioning immune system) represents a significant unmet need in patients requiring lymphodepletion...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29733960/effects-of-dietary-glucose-and-starch-levels-on-the-growth-apparent-digestibility-and-skin-associated-mucosal-non-specific-immune-parameters-in-juvenile-blunt-snout-bream-megalobrama-amblycephala
#5
Si-Lei Xia, Xiang-Fei Li, Kenneth Prudence Abasubong, Chao Xu, Hua-Juan Shi, Wen-Bin Liu, Ding-Dong Zhang
A 10-week feeding trial was performed to evaluate the effects of different types and levels of carbohydrates in growth performance, apparent digestibility coefficients and skin-associated mucosal non-specific immune parameters in blunt snout bream (Megalobrama amblycephala). Fish were randomly fed four diets containing two carbohydrates (glucose and starch) diets and two carbohydrates levels (330 and 440 g kg-1 ). High carbohydrate levels remarkably increased the weight gain rate (WGR), apparent digestibility of dry matters, protein and carbohydrates, body crud protein content, plasma levels of aspartate transaminase (AST), and skin-associated mucosal levels of immunoglobulin M (IgM), HDL cholesterol, lysozyme (LZM), advanced the transcriptions of mucin 2 (Muc2), mucin 5b (Muc5b) and apolipoprotein A-I (apoA-I), whereas the opposite was true for feed conversion ratio (FCR), plasma levels of IgM, skin-associated mucosal levels of major histocompatibility complex (MHC) and β-Defensins, and the transcriptions of heat shock protein 60 (Hsp60)...
May 4, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29729174/-substantiation-of-complex-intensive-treatment-of-hepatic-failure-complicated-by-encephalopathy
#6
Mikhaylo M Ivachevsky, Vitalina V Ivachevska
OBJECTIVE: Introduction: Thesis is devoted to the optimization of complex intensive therapy of hepatic insufficiency, complicated by encephalopathy. The aim: Optimization of treatment efficacy in patients with hepatic insufficiency complicated by encephalopathy. PATIENTS AND METHODS: Materials and methods: The results of complex examination and treatment of 73 patients with hepatic insufficiency have been studied and analyzed in this work. The study included patients who had been hospitalized with liver encephalopathy, which developed on the background of hepatic failure, cirrhosis of the liver in particular...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29709493/immune-parameters-in-different-age-classes-of-captive-male-steller-s-eiders-polysticta-stelleri
#7
Katrina L Counihan, Tuula E Hollmén
The immune system is important for host defense against antigens, but little is known about Steller's eider (Polysticta stelleri) immunology. This study compared hematological parameters, serum protein levels, lymphocyte proliferation, heat shock protein levels and oxidative damage in four different age classes of captive male Steller's eiders. The hatch year cohort had significantly higher total white blood cell and lymphocyte counts. The second year cohort had significantly higher albumin, alpha globulins and lymphocyte proliferation, and significantly lower beta globulin levels...
April 27, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29704554/growth-physiological-antioxidants-and-immune-response-of-african-catfish-clarias-gariepinus-b-to-dietary-clove-basil-ocimum-gratissimum-leaf-extract-and-its-susceptibility-to-listeria-monocytogenes-infection
#8
Mohsen Abdel-Tawwab, Ibrahim Adeshina, Adetola Jenyo-Oni, Emmanual K Ajani, Benjami O Emikpe
Clove basil, Ocimum gratissimum, is a native plant to Africa and grows virtually in tropical and subtropical regions. It has good aroma and its leaves have become used as a spicy and in traditional medicine. The use of plant leaves in fish diets may deteriorate their growth because it may content anti-nutritional factors0 Thus, it is better to use plants leaves extract. In the current study, clove basil leaves extract (CBLE) was administrated to African catfish, Clarias gariepinus (B.) for 12 weeks to evaluate its effect on growth performance, physiological, antioxidants, and innate immunity variables...
April 25, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29703032/acetylcholine-receptor-antibody-positive-myasthenia-gravis-associated-with-small-cell-lung-cancer-a-case-report
#9
Masahiro Yamasaki, Kunihiko Funaishi, Naomi Saito, Tomomi Yonekawa, Takemori Yamawaki, Daisuke Ihara, Wakako Daido, Sayaka Ishiyama, Naoko Deguchi, Masaya Taniwaki, Noboru Hattori
RATIONALE: Only few cases of myasthenia gravis (MG) associated with small-cell lung cancer (SCLC) have been reported, and cases positive for acetylcholine receptor antibody (AChR-ab) are even rarer. The efficacy of standard MG treatment, such as cholinesterase inhibitor therapy, immunosuppressive therapy using steroids and immunosuppressive drugs, plasma exchange, and intravenous immune globulin (IVIg), for these cases is unclear. PATIENT CONCERNS AND DIAGNOSES: A 71-year-old man complained of bilateral eyelid ptosis...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29692618/an-evaluation-of-the-budget-impact-of-a-new-20-subcutaneous-immunoglobulin-ig20gly-for-the-management-of-primary-immunodeficiency-diseases-in-switzerland
#10
Richard F Pollock, Lisa M Meckley
Introduction: While most individual primary immunodeficiency diseases (PID) are rare, the collective prevalence of PID results in a substantial economic and clinical burden. The aim of this study was to evaluate the budgetary implications of Ig20Gly (Immune Globulin Subcutaneous [human] 20% solution; CUVITRU ® , Baxalta US Inc, now part of Shire Plc, Westlake Village, CA, USA) as a treatment for PID relative to intravenous immunoglobulin (IVIG) and other subcutaneous immunoglobulin (SCIG) formulations in the Swiss health care setting...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29691272/immune-mediated-necrotising-myopathy-a-rare-cause-of-hyperckaemia
#11
Emily Liang, Mandana Rastegar
Immune-mediated necrotising myopathy (IMNM) is a type of inflammatory myopathy characterised by acute or subacute severe proximal muscle weakness, significantly elevated creatine kinase levels, and prominent myofibre necrosis and regeneration with little or no inflammation. A subtype of IMNM identified by anti-HMG-CoA reductase (HMGCR)antibodies has been shown to be associated with statin exposure. Treatment of IMNM consists of immunosuppression with steroids, steroid-sparing agents, intravenous immune globulin and/or biologics...
April 24, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29688045/effect-of-different-levels-of-essential-oils-satureja-hortensis-in-diet-on-improvement-growth-blood-biochemical-and-immunity-of-angelfish-pterophyllum-scalare-schultze-1823
#12
Hamed Ghafari Farsani, Mohammad Hasan Gerami, Mehdi Naderi Farsani, Ghasem Rashidiyan, Neda Mehdipour, Mona Ghanad, Caterina Faggio
The aim of this study was designed to analyse the effect of Savoury essential oil (Satureja hortensis) on growth performance, biochemical parameters and immunity of angelfish (Pterophyllum scalare). The angelfishes (average body weight of 5.12 ± 0.01 g) were treated with three effective dosage of Savoury essential oil 100, 200 and 400 mg/kg in three separated aquaria water with one control group for 60 days. At the end of experiment, the angelfishes treated with 400 mg/kg Satureja showed minimum Feed Conversion Ratio, maximum Specific Growth Rate and Survival Rate...
April 24, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29686051/cutting-edge-identification-of-marginal-reticular-cells-as-phagocytes-of-apoptotic-b-cells-in-germinal-centers
#13
Kazuki Sato, Shin-Ichiro Honda, Akira Shibuya, Kazuko Shibuya
Germinal centers (GCs) in secondary lymphoid organs generate large numbers of apoptotic B cells that must be eliminated by phagocytes to prevent the development of autoimmune diseases. Although tingible body macrophages engulf apoptotic GC B cells, whether stromal cells are also involved in this process is unclear. In this study, we identified marginal reticular cells (MRCs) as novel nonprofessional phagocytes for the clearance of apoptotic GC B cells in the spleen. We used CD19eGFP (CD19cre Z/EG) mice, which express enhanced GFP (eGFP) under the control of CD19cre expression, to track B cells in the GCs after immunization with NP-chicken γ globulin plus aluminum salt...
April 23, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29684602/trans-cinnamic-acid-application-for-rainbow-trout-oncorhynchus-mykiss-i-effects-on-haematological-serum-biochemical-non-specific-immune-and-head-kidney-gene-expression-responses
#14
Sevdan Yilmaz, Sebahattin Ergün
The present study investigated the effects of dietary trans-cinnamic acid (CA) on pre- and post-challenge haematological, serum biochemical, non-specific immune and head kidney gene expression responses of rainbow trout, Oncorhynchus mykiss juveniles. In this regard, fish with an average weight of 17.01 ± 0.05 g were divided into five groups, and fed daily with an additive free basal diet (control); 250, 500, 750 or 1500 mg kg-1  CA for a 60-day period. Fish were sampled every 20 days during the experiment...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684566/eltrombopag-for-the-treatment-of-of-refractory-pure-red-cell-aplasia-after-major-abo-incompatible-hematopoietic-stem-cell-transplantation
#15
Alessandro Busca, Chiara Dellacasa, Luisa Giaccone, Sara Manetta, Lucia Biale, Laura Godio, Semra Aydin, Moreno Festuccia, Lucia Brunello, Benedetto Bruno
Pure red cell aplasia (PRCS) is a well-recognized complication after allogeneic hematopoietic stem cell transplantation (HSCT). Many therapeutic options are available to treat this condition, including erythropoietin, rituximab, bortezomib, plasma exchange, immunoadsorption, donor lymphocyte infusion, mesenchymal stem cells, anti-thymocyte globulin and high-dose steroids; however treatment outcomes are often variable and can sometimes lead to disappointing results. In this brief article we report our experience with two patients with PRCA after major AB0-incompatible HSCT who were resistant to multiple therapeutic interventions and who eventually benefited from treatment with eltrombopag, a thrombopoietin mimetic approved by the Food and Drug Administration for the treatment of patients with immune thrombocytopenic purpura or severe aplastic anemia (SAA), refractory to immunosuppressive agents or not eligible to HSCT...
April 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29673941/use-of-hepatitis-a-vaccine-for-post-exposure-prophylaxis-in-individuals-over-40-years-of-age-a-systematic-review-of-published-studies-and-recommendations-for-vaccine-use
#16
REVIEW
Ruth Link-Gelles, Megan G Hofmeister, Noele P Nelson
INTRODUCTION: Hepatitis A can cause widespread outbreaks. Until 2018, postexposure prophylaxis (PEP) in the United States for individuals >40 years consisted of immune globulin (IG) administered as soon as possible after exposure, ideally within 14 days whereas those aged ≤40 should receive hepatitis A (HepA) vaccine. However, state health departments reporting difficulty quickly accessing and administering IG, costs of higher IG doses and importance of long-term HAV protection prompted CDC to review immunogenicity data for use of HepA vaccine for PEP in older adults...
April 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29668540/aplastic-anemia-as-an-immune-mediated-complication-of-thymoma-a-case-report
#17
Ersin Toret, Bengü Demirag, Sultan A Köker, Onur Doyurgan, Malik Ergin, Sinan Genc, Tuba H Karapinar, Yilmaz Ay, Yeşim Oymak, Canan Vergin
Thymomas are the most common masses located in the anterior mediastinum, and they are often associated with autoimmune disorders including myasthenia gravis, polymyositis, and aplastic anemia (AA). Autoreactive T-cell clones generated by the thymoma may lead to autoimmune disorders. We report the case of a 14-year-old boy who was examined for AA, and the underlying cause was determined to be an immune-mediated complication of thymoma. He had no matched sibling donors. He underwent thymectomy, and 3 months later he was treated with immunosuppressive therapy (IST), consisting of antithymocyte globulin and cyclosporine A...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29664567/memory-control-by-the-b-cell-antigen-receptor
#18
REVIEW
Niklas Engels, Jürgen Wienands
The generation of memory B cells (MBCs) that have undergone immunoglobulin class switching from IgM, which dominates primary antibody responses, to other immunoglobulin isoforms is a hallmark of immune memory. Hence, humoral immunological memory is characterized by the presence of serum immunoglobulins of IgG subtypes known as the γ-globulin fraction of blood plasma proteins. These antibodies reflect the antigen experience of B lymphocytes and their repeated triggering. In fact, efficient protection against a previously encountered pathogen is critically linked to the production of pathogen-specific IgG molecules even in those cases where the primary immune response required cellular immunity, for example, T cell-mediated clearance of intracellular pathogens such as viruses...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29657700/misleading-hepatitis-b-serology-following-rho-d-immune-globulin-human-injection-and-influenza-vaccine
#19
Xuanxuan Chen
Having a hepatitis B surface antibody (HBsAb) titre of more than 10 mIU/mL after hepatitis B vaccination is generally considered to confer immunity to hepatitis B. This case report discusses an unusual case of a false positive hepatitis B core total antibody (HBcAb) following administration of either Rho (D) immune globulin (Human) injection or influenza vaccine in a patriuent who was previously immunised against hepatitis B.
March 28, 2018: Clinics and Practice
https://www.readbyqxmd.com/read/29603406/metaphylactic-effect-of-minerals-on-the-immune-response-biochemical-variables-and-antioxidant-status-of-newborn-calves
#20
T Tomasi, A Volpato, W A B Pereira, L H Debastiani, N B Bottari, V M Morsch, M R C Schetinger, M L R Leal, G Machado, A S Da Silva
The aim of this study was to evaluate whether injectable zinc and copper affect host immune responses and antioxidant status of newborn calves. For this study, 19 newborn calves were divided into two groups. The control group consisted of 10 animals; and the treated group consisted of nine animals that received copper edetate (Cu-ed) and zinc edetate (Zn-ed) subcutaneously at the first day of life at doses of 0.3 mg/kg and 1.0 mg/kg respectively. Blood and faecal samples were collected for laboratory analyses (seric biochemistry, proteinogram, antioxidant enzymes and parasitological examination) on days 10, 20 and 30 after birth...
March 30, 2018: Journal of Animal Physiology and Animal Nutrition
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