Georg B Ehret, Youssef Daali, Jocelyne Chabert, Michela Rebsamen, Adriana Wolff, Alain Forster, Fouzia Moursli, Daniel Fritschy, Michel F Rossier, Valérie Piguet, Pierre Dayer, Marianne Gex-Fabry, Jules A Desmeules
BACKGROUND: There is some evidence that dextromethorphan (DM) is effective as a pre-emptive analgesic agent. DM is mainly metabolized to dextrorphan (DOR) by CYP2D6 whose activity can be inhibited by pharmacologic intervention. OBJECTIVES: To investigate the efficacy of DM as a pre-emptive analgesic agent and describe the population pharmacokinetics in the presence of normal and poor CYP2D6 metabolism in acute post-operative pain. STUDY DESIGN: Double blind, randomized, placebo-controlled trial SETTING: Post-surgical analgesic consumption after knee ligament surgery, a setting of acute pain...
January 2013: Pain Physician