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cyp2d6 vs postoperative analgesia

Ulrike M Stamer, Frank Musshoff, Frank Stüber, Jürgen Brockmöller, Michael Steffens, Mladen V Tzvetkov
The organic cation transporter OCT1 (SLC22A1) mediates uptake and metabolism of the active tramadol metabolite (+)O-desmethyltramadol in the liver. In this study, the influence of OCT1 genetic polymorphisms on pharmacokinetics and analgesic efficacy of tramadol in patients recovering from surgery was analyzed in addition to the CYP2D6 genotype. Postoperative patients who received tramadol through patient-controlled analgesia were enrolled. Genotypes resulting in 0, 1, or 2 active OCT1 alleles were determined as well as CYP2D6 genotypes...
November 2016: Pain
Georg B Ehret, Youssef Daali, Jocelyne Chabert, Michela Rebsamen, Adriana Wolff, Alain Forster, Fouzia Moursli, Daniel Fritschy, Michel F Rossier, Valérie Piguet, Pierre Dayer, Marianne Gex-Fabry, Jules A Desmeules
BACKGROUND: There is some evidence that dextromethorphan (DM) is effective as a pre-emptive analgesic agent.  DM is mainly metabolized to dextrorphan (DOR) by CYP2D6 whose activity can be inhibited by pharmacologic intervention. OBJECTIVES: To investigate the efficacy of DM as a pre-emptive analgesic agent and describe the population pharmacokinetics in the presence of normal and poor CYP2D6 metabolism in acute post-operative pain. STUDY DESIGN: Double blind, randomized, placebo-controlled trial SETTING: Post-surgical analgesic consumption after knee ligament surgery, a setting of acute pain...
January 2013: Pain Physician
O Slanar, P Dupal, O Matouskova, H Vondrackova, P Pafko, F Perlik
OBJECTIVES: The aim of our study was to evaluate impact of CYP2D6 and MDR1 polymorphisms on the analgesic efficacy of tramadol in patients after a knee arthroscopy. BACKGROUND: Pharmacokinetics of tramadol and its metabolites is stereoselective and displays high interindividual variability correlating with polymorphic CYP2D6 in the population. Available data provide controversial results regarding the analgesic efficacy of tramadol in subjects with different CYP2D6 genotypes...
2012: Bratislavské Lekárske Listy
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