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https://www.readbyqxmd.com/read/28657755/simultaneous-enhancement-of-photoluminescence-mri-relaxivity-and-ct-contrast-by-tuning-the-interfacial-layer-of-lanthanide-heteroepitaxial-nanoparticles
#1
Sha He, Noah J J Johnson, Viet Anh Nguyen Huu, Esther Cory, Yuran Huang, Robert L Sah, Jesse V Jokerst, Adah Almutairi
Nanoparticle (NP) based exogenous contrast agents assist biomedical imaging by enhancing the target visibility against the background. However, it is challenging to design a single type of contrast agents that are simultaneously suitable for various imaging modalities. The simple integration of different components into a single NP contrast agent does not guarantee the optimized properties of each individual components. Herein, we describe lanthanide-based core-shell-shell (CSS) NPs as triple-modal contrast agents that have concurrently enhanced performance compared to their individual components in photoluminescence (PL) imaging, magnetic resonance imaging (MRI), and computed tomography (CT)...
July 7, 2017: Nano Letters
https://www.readbyqxmd.com/read/28650446/exosomes-from-plasmodium-infected-hosts-inhibit-tumor-angiogenesis-in-a-murine-lewis-lung-cancer-model
#2
Y Yang, Q Liu, J Lu, D Adah, S Yu, S Zhao, Y Yao, L Qin, L Qin, X Chen
Previous research to investigate the interaction between malaria infection and tumor progression has revealed that malaria infection can potentiate host immune response against tumor in tumor-bearing mice. Exosomes may play key roles in disseminating pathogenic host-derived molecules during infection because several studies have shown the involvement and roles of extracellular vesicles in cell-cell communication. However, the role of exosomes generated during Plasmodium infection in tumor growth, progression and angiogenesis has not been studied either in animals or in the clinics...
June 26, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28599597/simultaneous-knockout-of-cxcr4-and-ccr5-genes-in-cd4-t-cells-via-crispr-cas9-confers-resistance-to-both-x4-and-r5-tropic-human-immunodeficiency-virus-type-1-infection
#3
Songlin Yu, Yongchao Yao, Hongkui Xiao, Jiaojiao Li, Quan Liu, Yijun Yang, Dickson Adah, Junnan Lu, Siting Zhao, Li Qin, Xiaoping Chen
Previous research has proven that disruption of either the CCR5 or the CXCR4 gene confers resistance to R5-tropic or X4-tropic human immunodeficiency virus type 1 (HIV-1) infection, respectively. However, the urgent need to ablate both of the co-receptors in individual post-thymic CD4+ T cells for dual protection remains. This study ablated the CCR5 and CXCR4 genes in human CD4+ cell lines and primary CD4+ T cells simultaneously using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9, a well-developed, highly efficient genetic engineering tool...
June 9, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28445973/plasmodium-parasite-as-an-effective-hepatocellular-carcinoma-antigen-glypican-3-delivery-vector
#4
Quan Liu, Yijun Yang, Xuefang Tan, Zhu Tao, Dickson Adah, Songlin Yu, Junnan Lu, Siting Zhao, Limei Qin, Li Qin, Xiaoping Chen
We have previously demonstrated that malaria parasite infection has an anti-tumor effect in a mouse model. This research aimed to investigate the possibility of using Plasmodium parasite as a novel vaccine vector for hepatocellular carcinoma (HCC) immunotherapy. We constructed a Plasmodium yoelii 17XNL strain (P.y) expressing murine glypican-3 (GPC3) protein (P.y-GPC3), and examined its therapeutic potency in a murine Hepa1-6-induced hepatoma model that highly expressed GPC3 protein. The prerequisites for invoking a CD8+ T cell response were assessed after P...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28433935/distinct-on-off-fluorescence-signals-from-dual-responsive-activatable-nanoprobes-allows-detection-of-inflammation-with-improved-contrast
#5
Mathieu L Viger, Guillaume Collet, Jacques Lux, Viet Anh Nguyen Huu, Monica Guma, Alexandra Foucault-Collet, Jason Olejniczak, Shivanjali Joshi-Barr, Gary S Firestein, Adah Almutairi
Visualization of biochemical changes associated with disease is of great clinical significance, as it should allow earlier, more accurate diagnosis than structural imaging, facilitating timely clinical intervention. Herein, we report combining stimuli-responsive polymers and near-infrared fluorescent dyes (emission max: 790 nm) to create robust activatable fluorescent nanoprobes capable of simultaneously detecting acidosis and oxidative stress associated with inflammatory microenvironments. The spectrally-resolved mechanism of fluorescence activation allows removal of unwanted background signal (up to 20-fold reduction) and isolation of a pure activated signal, which enables sensitive and unambiguous localization of inflamed areas; target-to-background ratios reach 22 as early as 3 h post-injection...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28318449/through-the-lens-of-attachment-relationship-stable-did-active-did-and-other-trauma-based-mental-disorders
#6
Adah Sachs
Some people with DID, despite years of DID-specific therapy (using the three-phase approach, ISSTD, 2011), seem unable to get better. In particular, they seem unable to remain physically safe ("Phase One") and report continued exposure to abuse. As every fresh hurt causes fresh dissociation, their DID becomes further entrenched over time. Moreover, as dissociation makes the person more vulnerable to being re-abused, they become caught up in a vicious cycle, which further obstructs their efforts toward recovery...
May 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28318395/the-abused-and-the-abuser-victim-perpetrator-dynamics
#7
Warwick Middleton, Adah Sachs, Martin J Dorahy
No abstract text is available yet for this article.
May 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28169535/direct-evidence-for-coupled-surface-and-concentration-quenching-dynamics-in-lanthanide-doped-nanocrystals
#8
Noah J J Johnson, Sha He, Shuo Diao, Emory M Chan, Hongjie Dai, Adah Almutairi
Luminescence quenching at high dopant concentrations generally limits the dopant concentration to less than 1-5 mol% in lanthanide-doped materials, and this remains a major obstacle in designing materials with enhanced efficiency/brightness. In this work, we provide direct evidence that the major quenching process at high dopant concentrations is the energy migration to the surface (i.e., surface quenching) as opposed to the common misconception of cross-relaxation between dopant ions. We show that after an inert epitaxial shell growth, erbium (Er(3+)) concentrations as high as 100 mol% in NaY(Er)F4/NaLuF4 core/shell nanocrystals enhance the emission intensity of both upconversion and downshifted luminescence across different excitation wavelengths (980, 800, and 658 nm), with negligible concentration quenching effects...
February 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28039365/complete-prevalence-of-malignant-primary-brain-tumors-registry-data-in-the-united-states-compared-with-other-common-cancers-2010
#9
Adah S Zhang, Quinn T Ostrom, Carol Kruchko, Lisa Rogers, David M Peereboom, Jill S Barnholtz-Sloan
Background.: Complete prevalence proportions illustrate the burden of disease in a population. This study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) histology groups, and compares the brain tumor prevalence estimates to the complete prevalence of other common cancers as determined by the Surveillance, Epidemiology, and End Results Program (SEER) by age at prevalence (2010): children (0-14 y), adolescent and young adult (AYA) (15-39 y), and adult (40+ y)...
May 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/27981322/biorthogonal-click-chemistry-on-poly-lactic-co-glycolic-acid-polymeric-particles
#10
Jason Olejniczak, Guillaume Collet, Viet Anh Nguyen Huu, Minnie Chan, Sangeun Lee, Adah Almutairi
Biodegradable polymeric materials are a key area of investigation in drug delivery and disease treatment. This is due to their proven clinical potential for payload protection, responsivity, and surface modification imparted by the versatile array of polymers available for their formulation. Here, we employ a novel biodegradable azide containing polymer in the formulation of polymeric nanoparticles and show that these particles can then be functionalized, with biorthogonal click reactions, to alter their surface appearance and their ability to interact with biological systems...
December 16, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27718336/characterization-of-foot-and-mouth-disease-viruses-collected-in-nigeria-between-2007-and-2014-evidence-for-epidemiological-links-between-west-and-east-africa
#11
H G Ularamu, J O Ibu, B A Wood, J N Abenga, D D Lazarus, Y S Wungak, N J Knowles, J Wadsworth, V Mioulet, D P King, D Shamaki, M I Adah
This study describes the molecular characterization of 47 foot-and-mouth disease (FMD) viruses recovered from field outbreaks in Nigeria between 2007 and 2014. Antigen ELISA of viral isolates was used to identify FMD virus serotypes O, A and SAT 2. Phylogenetic analyses of VP1 nucleotide sequences provide evidence for the presence of multiple sublineages of serotype SAT 2, and O/EAST AFRICA 3 (EA-3) and O/WEST AFRICA topotypes in the country. In contrast, for serotype A, a single monophyletic cluster of viruses has persisted within Nigeria (2009-2013)...
October 7, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27588579/compact-micellization-a-strategy-for-ultrahigh-t1-magnetic-resonance-contrast-with-gadolinium-based-nanocrystals
#12
Noah J J Johnson, Sha He, Viet Anh Nguyen Huu, Adah Almutairi
Paramagnetic gadolinium (Gd(3+))-based nanocrystals (NCs) with a large number of confined gadolinium ions can be expected to heavily enhance the longitudinal (T1) relaxation of water protons compared to clinical gadolinium complexes with only a single paramagnetic center. However, paramagnetic Gd(3+)-NCs reported to date show only a modest T1 relaxivity of ∼10 mM(-1) s(-1) per Gd(3+) at 1.5 T, only about 3-times higher than clinical Gd(3+) complexes. Here we demonstrate a strategy that achieves ultrahigh T1 relaxivity that is about 25-times higher than clinical Gd(3+) complexes by controlling the proximity of water protons to a paramagnetic NC surface...
September 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27410563/enhanced-uv-upconversion-emission-using-plasmonic-nanocavities
#13
Ahmed El Halawany, Sha He, Hossein Hodaei, Ahmed Bakry, Mir A N Razvi, Ahmed Alshahrie, Noah J J Johnson, Demetrios N Christodoulides, Adah Almutairi, Mercedeh Khajavikhan
Upconversion of near infrared (NIR) into ultraviolet (UV) radiation could lead to a number of applications in bio-imaging, diagnostics and drug delivery. However, for bare nanoparticles, the conversion efficiency is extremely low. In this work, we experimentally demonstrate strongly enhanced upconversion emission from an ensemble of β-NaYF<sub>4</sub>:Gd<sup>3+</sup>/Yb<sup>3+</sup>/Tm<sup>3+</sup> @NaLuF<sub>4</sub> core-shell nanoparticles trapped in judiciously designed plasmonic nanocavities...
June 27, 2016: Optics Express
https://www.readbyqxmd.com/read/27398218/nanogels-as-imaging-agents-for-modalities-spanning-the-electromagnetic-spectrum
#14
Minnie Chan, Adah Almutairi
In the past few decades, advances in imaging equipment and protocols have expanded the role of imaging in in vivo diagnosis and disease management, especially in cancer. Traditional imaging agents have rapid clearance and low specificity for disease detection. To improve accuracy in disease identification, localization and assessment, novel nanomaterials are frequently explored as imaging agents to achieve high detection specificity and sensitivity. A promising material for this purpose are hydrogel nanoparticles, whose high hydrophilicity, biocompatibility, and tunable size in the nanometer range make them ideal for imaging...
January 21, 2016: Materials Horizons
https://www.readbyqxmd.com/read/27302094/whole-genomic-analysis-of-human-and-bovine-g8p-1-rotavirus-strains-isolated-in-nigeria-provides-evidence-for-direct-bovine-to-human-interspecies-transmission
#15
Satoshi Komoto, Mohammed Ignatius Adah, Tomihiko Ide, Tetsushi Yoshikawa, Koki Taniguchi
Bovine group A rotavirus (RVA) G8P[1] strains have been rarely detected in humans. Two Nigerian G8P[1] strains, HMG035 (RVA/Human-tc/NGA/HMG035/1999/G8P[1]) and NGRBg8 (RVA/Cow-tc/NGA/NGRBg8/1998/G8P[1]), were previously suggested to have the VP7, VP4, and NSP1 genes of bovine origin. In order to obtain precise information on the origin and evolution of these G8P[1] strains, the complete nucleotide sequences of the whole genomes of strains HMG035 and NGRBg8 were determined and analyzed in the present study...
September 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27157248/implications-of-mdscs-targeting-in-lung-cancer-chemo-immunotherapeutics
#16
REVIEW
Dickson Adah, Muzammal Hussain, Limei Qin, Li Qin, Jiancun Zhang, Xiaoping Chen
Despite advances in chemotherapy and immunotherapy, advanced lung cancer remains an incurable disease. Novel trends in anticancer therapeutics focus on harnessing the therapeutically-targeted tumor-related immune suppression. In this respect, myeloid-derived suppressor cells (MDSCs) have captured considerable attention in the last few years, as they are vividly implicated in tumor immune escape mechanisms. In this review, we specifically discuss the multifaceted roles of MDSCs in lung tumor microenvironment, encompassing lung tumor growth and progression via suppression of anti-tumor immunity, association with worse prognosis, and hampering the efficacy of lung cancer chemotherapy and immunotherapy...
August 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27014436/efficient-red-light-photo-uncaging-of-active-molecules-in-water-upon-assembly-into-nanoparticles
#17
Carl-Johan Carling, Jason Olejniczak, Alexandra Foucault-Collet, Guillaume Collet, Mathieu L Viger, Viet Anh Nguyen Huu, Brendan M Duggan, Adah Almutairi
We introduce a means of efficiently photo-uncaging active compounds from amino-1,4-benzoquinone in aqueous environments. Aqueous photochemistry of this photocage with one-photon red light is typically not efficient unless the photocaged molecules are allowed to assemble into nanoparticles. A variety of biologically active molecules were functionalized with the photocage and subsequently formulated into water-dispersible nanoparticles. Red light irradiation through various mammalian tissues achieved efficient photo-uncaging...
March 2016: Chemical Science
https://www.readbyqxmd.com/read/26944080/layered-hydrogels-accelerate-ipsc-derived-neuronal-maturation-and-reveal-migration-defects-caused-by-mecp2-dysfunction
#18
Zhen-Ning Zhang, Beatriz C Freitas, Hao Qian, Jacques Lux, Allan Acab, Cleber A Trujillo, Roberto H Herai, Viet Anh Nguyen Huu, Jessica H Wen, Shivanjali Joshi-Barr, Jerome V Karpiak, Adam J Engler, Xiang-Dong Fu, Alysson R Muotri, Adah Almutairi
Probing a wide range of cellular phenotypes in neurodevelopmental disorders using patient-derived neural progenitor cells (NPCs) can be facilitated by 3D assays, as 2D systems cannot entirely recapitulate the arrangement of cells in the brain. Here, we developed a previously unidentified 3D migration and differentiation assay in layered hydrogels to examine how these processes are affected in neurodevelopmental disorders, such as Rett syndrome. Our soft 3D system mimics the brain environment and accelerates maturation of neurons from human induced pluripotent stem cell (iPSC)-derived NPCs, yielding electrophysiologically active neurons within just 3 wk...
March 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26640598/haptotaxis-is-cell-type-specific-and-limited-by-substrate-adhesiveness
#19
Jessica H Wen, Onkiu Choi, Hermes Taylor-Weiner, Alexander Fuhrmann, Jerome V Karpiak, Adah Almutairi, Adam J Engler
Motile cells navigate through tissue by relying on tactile cues from gradients provided by extracellular matrix (ECM) such as ligand density or stiffness. Mesenchymal stem cells (MSCs) and fibroblasts encounter adhesive or 'haptotactic' gradients at the interface between healthy and fibrotic tissue as they migrate towards an injury site. Mimicking this phenomenon, we developed tunable RGD and collagen gradients in polyacrylamide hydrogels of physiologically relevant stiffness using density gradient multilayer polymerization (DGMP) to better understand how such ligand gradients regulate migratory behaviors...
December 1, 2015: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/26445896/light-triggered-chemical-amplification-to-accelerate-degradation-and-release-from-polymeric-particles
#20
Jason Olejniczak, Viet Anh Nguyen Huu, Jacques Lux, Madeleine Grossman, Sha He, Adah Almutairi
We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.
December 11, 2015: Chemical Communications: Chem Comm
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