Ahmed Abdelhak, Franziska Petermeier, Pascal Benkert, Sabine Schädelin, Johanna Oechtering, Aleksandra Maleska Maceski, Michael Kabesch, Tobias Geis, Otto Laub, Georg Leipold, Claudio Gobbi, Chiara Zecca, Ari Green, Hayrettin Tumani, Eline Willemse, Heinz Wiendl, Cristina Granziera, Ludwig Kappos, David Leppert, Emmanuelle Waubant, Sven Wellmann, Jens Kuhle
BACKGROUND: Neurological conditions represent an important driver of paediatric disability burden worldwide. Measurement of serum neurofilament light chain (sNfL) concentrations, a specific marker of neuroaxonal injury, has the potential to contribute to the management of children with such conditions. In this context, the European Medicines Agency recently declared age-adjusted reference values for sNfL a top research priority. We aimed to establish an age-adjusted sNfL reference range database in a population of healthy children and adolescents, and to validate this database in paediatric patients with neurological conditions to affirm its clinical applicability...
September 2023: Lancet Neurology