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https://www.readbyqxmd.com/read/27914660/radiographic-and-clinical-results-of-tension-suture-fixation-using-two-washers-with-philos-plate-for-proximal-humeral-fractures
#1
Chul-Hyun Cho, Du Han Kim, Beom-Soo Kim
INTRODUCTION: The purpose of this study was to evaluate the radiographic and clinical results of tension suture fixation using two washers with PHILOS plate (Synthes, West Chester, PA, USA) for proximal humeral fractures. PATIENTS AND METHODS: Consecutive 39 patients were included and divided into two groups of adequate and inadequate medial support (MS (+) group vs MS (-) group). The mean follow-up period was 45months (range: 26-69 months). The mean age at the time of surgery was 59 years (range: 17-86 years) and there were 12 men and 27 women...
November 28, 2016: Injury
https://www.readbyqxmd.com/read/27866913/minimally-invasive-plate-osteosynthesis-with-philos-plate-for-proximal-humerus-fractures
#2
Uğur Gönç, Mesut Atabek, Kürşat Teker, Altuğ Tanrıöver
OBJECTIVES: The aim of the present study was to evaluate results, including clinical and radiological outcomes and number of complications, following minimally invasive plate osteosynthesis (MIPO) of proximal humerus fractures, using the PHILOS® proximal humerus internal locking system (Synthes Holding AG, Solothurn, Switzerland). METHODS: Retrospectively evaluated were 31 patients treated with MIPO (12 male, 19 female; average age: 58.4 years). Four patients had 2-part fractures, 14 patients had 3-part fractures, and 13 patients had 4-part fractures, according to Neer classification...
November 18, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27861483/-on-roman-philonium
#3
Guillermo Delgado-García, Carolina Rodríguez-Návarez, Bruno Estañol
The roman philonium (Philonium Romanum) is an example of pharmacological poetry. This opiate was conceived by Philo of Tarsus, who was active during the first century of the Common Era. His antidote was written in elegiac couplets. The conservation of these couplets is owed to Galen, who reproduced them in the ninth book of On the Composition of Medicines according to the Places. Most of this Galenic treatise has not been translated into Spanish. For the first time, we offer this prescription in our language from a French version of the fin de siècle...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27807647/epigenetic-transcriptional-memory
#4
REVIEW
Agustina D'Urso, Jason H Brickner
Organisms alter gene expression to adapt to changes in environmental conditions such as temperature, nutrients, inflammatory signals, and stress (Gialitakis et al. in Mol Cell Biol 30:2046-2056, 2010; Conrath in Trends Plant Sci 16:524-531, 2011; Avramova in Plant J 83:149-159, 2015; Solé et al. in Curr Genet 61:299-308, 2015; Ho and Gasch in Curr Genet 61:503-511, 2015; Bevington et al. in EMBO J 35:515-535, 2016; Hilker et al. in Biol Rev Camb Philos Soc 91:1118-1133, 2016). In some cases, organisms can "remember" a previous environmental condition and adapt to that condition more rapidly in the future (Gems and Partridge 2008)...
November 2, 2016: Current Genetics
https://www.readbyqxmd.com/read/27793135/operative-treatment-of-2-part-surgical-neck-fractures-of-the-proximal-humerus-ao-11-a3-in-the-elderly-cement-augmented-locking-plate-philos%C3%A2-vs-proximal-humerus-nail-multiloc%C3%A2
#5
Tobias Helfen, Georg Siebenbürger, Marcel Mayer, Wolfgang Böcker, Ben Ockert, Florian Haasters
BACKGROUND: Proximal humeral fractures are with an incidence of 4-5 % the third most common fractures in the elderly. In 20 % of humeral fractures there is an indication for surgical treatment according to the modified Neer-Criteria. A secondary varus dislocation of the head fragment and cutting-out are the most common complications of angle stable locking plates in AO11-A3 fractures of the elderly. One possibility to increase the stability of the screw-bone-interface is the cement augmentation of the screw tips...
October 28, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27787334/temperate-performance-benefits-after-heat-but-not-combined-heat-and-hypoxic-training
#6
Erin L McCleave, Katie M Slattery, Rob Duffield, Philo U Saunders, Avish P Sharma, Stephen J Crowcroft, Aaron J Coutts
INTRODUCTION: Independent heat and hypoxic exposure can enhance temperate endurance performance in trained athletes, although their combined effects remain unknown. This study examined whether the addition of heat interval training during 'Live High, Train Low' (LHTL) hypoxic exposure would result in enhanced performance and physiological adaptations as compared to heat or temperate training. METHODS: Twenty-six well-trained runners completed three weeks of interval training assigned to one of three conditions: 1) LHTL hypoxic exposure plus heat training (H+H; 3000 m for 13 h·day, train at 33°C, 60% RH), 2) heat training with no hypoxic exposure (HOT, live at <600m and train at 33°C, 60% RH), or 3) temperate training with no hypoxic exposure (CONT; live at <600m and train at 14°C, 55% RH)...
October 27, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27736249/training-at-2100-m-altitude-affects-running-speed-and-session-rpe-at-different-intensities-in-elite-middle-distance-runners
#7
Avish P Sharma, Laura A Garvican-Lewis, Brad Clark, Jamie Stanley, Eileen Y Robertson, Philo U Saunders, Kevin G Thompson
PURPOSE: This investigation sought to determine the effect of training at 2100 metres natural altitude on running speed (RS) during training sessions over a range of intensities relevant to middle-distance running performance. METHODS: In an observational study, 19 elite middle-distance runners (mean ± SD; Age, 25 ± 5 years; VO2 max, 71 ± 5 ml.kg.min-1) completed either 4-6 weeks of sea-level training (CON, n = 7), or a 4-5 week natural altitude training camp living at 2100 m and training at 1400-2700 m (ALT, n = 12) following a period of sea-level training...
October 13, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27685654/species-determination-and-quantitation-in-mixtures-using-mrm-mass-spectrometry-of-peptides-applied-to-meat-authentication
#8
Yvonne Gunning, Andrew D Watson, Neil M Rigby, Mark Philo, Joshua K Peazer, E Kate Kemsley
We describe a simple protocol for identifying and quantifying the two components in binary mixtures of species possessing one or more similar proteins. Central to the method is the identification of 'corresponding proteins' in the species of interest, in other words proteins that are nominally the same but possess species-specific sequence differences. When subject to proteolysis, corresponding proteins will give rise to some peptides which are likewise similar but with species-specific variants. These are 'corresponding peptides'...
September 20, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27594168/second-generation-locked-plating-for-complex-proximal-humerus-fractures-in-very-elderly-patients
#9
Ashok S Gavaskar, Bhupesh Karthik B, Naveen C Tummala, Parthasarathy Srinivasan, Hitesh Gopalan
OBJECTIVES: Humeral head sacrificing procedures are more favored in elderly patients with complex proximal humerus fractures because of high incidence of failures and complications with osteosynthesis. The purpose of this study is to assess the outcome of second generation locked plating techniques in 3 and 4 part fractures in active elderly patients >70years with an emphasis on function and complications. MATERIALS AND METHODS: 29 patients with displaced 3 and 4 part proximal humerus fractures were treated using the principles of second-generation proximal humerus locked plating...
August 24, 2016: Injury
https://www.readbyqxmd.com/read/27554952/what-effect-does-transition-have-on-health-and-well-being-in-young-people-with-intellectual-disabilities-a-systematic-review
#10
Genevieve Young-Southward, Christopher Philo, Sally-Ann Cooper
BACKGROUND: Transition to adulthood might be a risk period for poor health in people with intellectual disabilities. However, the present authors could find no synthesis of evidence on health and well-being outcomes during transition in this population. This review aimed to answer this question. METHOD: PRISMA/MOOSE guidelines were followed. Search terms were defined, electronic searches of six databases were conducted, reference lists and key journals were reviewed, and grey literature was searched...
August 24, 2016: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/27538152/-analysis-of-early-failure-of-the-philos-in-proximal-humerus-fractures
#11
J W Wu, H L Shen, L M Liu, Z H Gao
OBJECTIVE: To analyze the reasons of early failure of the PHILOS in proximal humerus fractures. METHODS: From Nov. 2010 to Nov. 2014, there were 117 patients with humerus fractures treated with PHILOS locking plate in Department of Orthopaedics, Xuanwu Hospital. All of the patients were treated with the plate by open reduction internal fixation, and we analyzed these cases retrospectively. After the operation, we removed the drainage tube within 48 h, and the patients were allowed to do the passive motion 3 days after the surgery if the X-Ray showed the plate and screws were reliable...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27492633/accurate-application-of-a-precontoured-locking-plate-for-proximal-humeral-fractures-in-asians-a-cadaveric-study
#12
Ji-Yong Kwak, Hyung-Bin Park, Gu-Hee Jung
OBJECTIVES: The purpose of this study was to identify the optimal position for a precontoured-locking plating (PHILOS(®)) of the proximal humerus in Asians in terms of conformity and to determine the prevalence of screw exits in the position of the highest conformity. METHODS: Twenty adult humeri and 14 cadaveric shoulders were included in this study. After placing the precontoured plate in the well-fitted position on the humerus, we measured the distance between the upper margin of the plate and the tip of greater tuberosity (GT) (distance A) and the distance between the anterior margin of the plate and lateral border of the bicipital groove (BG) (distance B)...
October 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27459673/four-weeks-of-classical-altitude-training-increases-resting-metabolic-rate-in-highly-trained-middle-distance-runners
#13
Amy L Woods, Avish P Sharma, Laura A Garvican-Lewis, Philo Saunders, Tony Rice, Kevin G Thompson
High altitude exposure can increase resting metabolic rate (RMR) and induce weight loss in obese populations, but there is a lack of research regarding RMR in athletes at moderate elevations common to endurance training camps. The present study aimed to determine whether four weeks of classical altitude training affects RMR in middle-distance runners. Ten highly-trained athletes were recruited for four weeks of endurance training undertaking identical programs at either 2200m in Flagstaff, Arizona (ALT, n=5) or 600m in Canberra, Australia (CON, n=5)...
August 24, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27443061/strategic-planning-a-practical-primer-for-the-healthcare-provider-part-i
#14
Neil Baum, Erich N Brockmann, Kenneth J Lacho
Entrepreneurs are known for opportunity recognition--that is, "How can I start a business to make money from this opportunity?" However, once a commercial entity is formed to take advantage of an opportunity, the leadership priority shifts from entrepreneurial to strategic. A strategic perspective leverages limited resources to position a business for future success relative to rivals in a competitive environment. Often, the talents needed for one priority are not the same as those needed for the other. This article, the first part of a two-part article, intends to simplify the transition from an entrepreneurial to a strategic focus...
May 2016: Journal of Medical Practice Management: MPM
https://www.readbyqxmd.com/read/27329037/does-epicatechin-contribute-to-the-acute-vascular-function-effects-of-dark-chocolate-a-randomized-crossover-study
#15
James I Dower, Johanna M Geleijnse, Paul A Kroon, Mark Philo, Marco Mensink, Daan Kromhout, Peter C H Hollman
SCOPE: Cocoa, rich in flavan-3-ols, improves vascular function, but the contribution of specific flavan-3-ols is unknown. We compared the effects of pure epicatechin, a major cocoa flavan-3-ol, and chocolate. METHODS AND RESULTS: In a randomized crossover study, twenty healthy men (40-80 years) were supplemented with: (1) 70g dark chocolate (150 mg epicatechin) with placebo capsules; (2) pure epicatechin capsules (2 × 50 mg epicatechin) with 75g white chocolate; and (3) placebo capsules with 75 g white chocolate (0 mg epicatechin)...
June 22, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27151177/sitagliptin-vs-placebo-for-non-alcoholic-fatty-liver-disease-a-randomized-controlled-trial
#16
Jeffrey Cui, Len Philo, Phirum Nguyen, Heather Hofflich, Carolyn Hernandez, Ricki Bettencourt, Lisa Richards, Joanie Salotti, Archana Bhatt, Jonathan Hooker, William Haufe, Catherine Hooker, David A Brenner, Claude B Sirlin, Rohit Loomba
BACKGROUND & AIMS: Uncontrolled studies show sitagliptin, an oral DPP-4 inhibitor, may improve alanine aminotransferase and liver histology in non-alcoholic fatty liver disease (NAFLD) patients. We aimed to compare sitagliptin vs. the efficacy of a placebo in reducing liver fat measured by MRI-derived proton density-fat fraction (MRI-PDFF). METHODS: This randomized, double-blind, allocation-concealed, placebo-controlled trial included 50 NAFLD patients with prediabetes or early diabetes randomized to sitagliptin orally 100mg/day or placebo for 24weeks...
August 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27128564/inferiority-of-ticagrelor-in-the-philo-trial-play-of-chance-in-east-asians-or-nightmare-confirmation-of-plato-usa
#17
EDITORIAL
Victor L Serebruany, Ales Tomek, Yury Pya, Makhabbat Bekbossynova, Moo Hyun Kim
Long-awaiting PHILO trial, conducted in 2011-2012 has been submitted and published late in 2015. In contrast to overall PLATO results, but similar to PLATO-US cohort, PHILO revealed numerical inferiority of ticagrelor with regard to death, myocardial infarction, stroke, and bleeding over clopidogrel. Hence, we comprehend the PHILO results in light of the PLATO-US evidence. To assess the PHILO (n=801) outcomes, applied statistics, and trial conduct, matching them with the PLATO-US (n=1413) patients. The Asian, predominantly Japanese ticagrelor patients had worsened outcomes even when compared to the negative American cohort with regard to death (OR=1...
July 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27127310/potential-for-measurement-of-the-distribution-of-dna-folds-in-complex-environments-using-correlated-x-ray-scattering
#18
Gundolf Schenk, Brad Krajina, Andrew Spakowitz, Sebastian Doniach
In vivo chromosomal behavior is dictated by the organization of genomic DNA at length scales ranging from nanometers to microns. At these disparate scales, the DNA conformation is influenced by a range of proteins that package, twist and disentangle the DNA double helix, leading to a complex hierarchical structure that remains undetermined. Thus, there is a critical need for methods of structural characterization of DNA that can accommodate complex environmental conditions over biologically relevant length scales...
March 30, 2016: Modern Physics Letters. B, Condensed Matter Physics, Statistical Physics, Applied Physics
https://www.readbyqxmd.com/read/27047867/evaluation-of-the-complications-of-surgical-treatment-of-fractures-of-the-proximal-extremity-of-the-humerus-using-a-locking-plate
#19
Alberto Naoki Miyazaki, José Renato Depari Estelles, Marcelo Fregoneze, Pedro Doneux Santos, Luciana Andrade da Silva, Guilherme do Val Sella, Fábio Eduardo Ishioka, João Polydoro Rosa, Sergio Luiz Checchia
OBJECTIVE: To evaluate the complications from surgical treatment using a locking plate among patients with fractures of the proximal extremity of the humerus. METHODS: Between July 2004 and December 2009, 56 patients with fractures of the proximal extremity of the humerus were treated using the PHILOS(®) plate. There were 19 male patients and 37 female patients, with a mean age of 62 years (range: 30 to 92 years). All the cases had a mean postoperative followup period of 12 months...
September 2012: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/27047304/orientation-relationship-of-eutectoid-feal-and-feal2
#20
A Scherf, A Kauffmann, S Kauffmann-Weiss, T Scherer, X Li, F Stein, M Heilmaier
Fe-Al alloys in the aluminium range of 55-65 at.% exhibit a lamellar microstructure of B2-ordered FeAl and triclinic FeAl2, which is caused by a eutectoid decomposition of the high-temperature Fe5Al8 phase, the so-called ∊ phase. The orientation relationship of FeAl and FeAl2 has previously been studied by Bastin et al. [J. Cryst. Growth (1978 ▸), 43, 745] and Hirata et al. [Philos. Mag. Lett. (2008 ▸), 88, 491]. Since both results are based on different crystallographic data regarding FeAl2, the data are re-evaluated with respect to a recent re-determination of the FeAl2 phase provided by Chumak et al...
April 1, 2016: Journal of Applied Crystallography
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