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Avish P Sharma, Laura A Garvican-Lewis, Brad Clark, Jamie Stanley, Eileen Y Robertson, Philo U Saunders, Kevin G Thompson
PURPOSE: This investigation sought to determine the effect of training at 2100 metres natural altitude on running speed (RS) during training sessions over a range of intensities relevant to middle-distance running performance. METHODS: In an observational study, 19 elite middle-distance runners (mean ± SD; Age, 25 ± 5 years; VO2 max, 71 ± 5 completed either 4-6 weeks of sea-level training (CON, n = 7), or a 4-5 week natural altitude training camp living at 2100 m and training at 1400-2700 m (ALT, n = 12) following a period of sea-level training...
October 13, 2016: International Journal of Sports Physiology and Performance
Yvonne Gunning, Andrew D Watson, Neil M Rigby, Mark Philo, Joshua K Peazer, E Kate Kemsley
We describe a simple protocol for identifying and quantifying the two components in binary mixtures of species possessing one or more similar proteins. Central to the method is the identification of 'corresponding proteins' in the species of interest, in other words proteins that are nominally the same but possess species-specific sequence differences. When subject to proteolysis, corresponding proteins will give rise to some peptides which are likewise similar but with species-specific variants. These are 'corresponding peptides'...
2016: Journal of Visualized Experiments: JoVE
Ashok S Gavaskar, Bhupesh Karthik B, Naveen C Tummala, Parthasarathy Srinivasan, Hitesh Gopalan
OBJECTIVES: Humeral head sacrificing procedures are more favored in elderly patients with complex proximal humerus fractures because of high incidence of failures and complications with osteosynthesis. The purpose of this study is to assess the outcome of second generation locked plating techniques in 3 and 4 part fractures in active elderly patients >70years with an emphasis on function and complications. MATERIALS AND METHODS: 29 patients with displaced 3 and 4 part proximal humerus fractures were treated using the principles of second-generation proximal humerus locked plating...
August 24, 2016: Injury
Genevieve Young-Southward, Christopher Philo, Sally-Ann Cooper
BACKGROUND: Transition to adulthood might be a risk period for poor health in people with intellectual disabilities. However, the present authors could find no synthesis of evidence on health and well-being outcomes during transition in this population. This review aimed to answer this question. METHOD: PRISMA/MOOSE guidelines were followed. Search terms were defined, electronic searches of six databases were conducted, reference lists and key journals were reviewed, and grey literature was searched...
August 24, 2016: Journal of Applied Research in Intellectual Disabilities: JARID
J W Wu, H L Shen, L M Liu, Z H Gao
OBJECTIVE: To analyze the reasons of early failure of the PHILOS in proximal humerus fractures. METHODS: From Nov. 2010 to Nov. 2014, there were 117 patients with humerus fractures treated with PHILOS locking plate in Department of Orthopaedics, Xuanwu Hospital. All of the patients were treated with the plate by open reduction internal fixation, and we analyzed these cases retrospectively. After the operation, we removed the drainage tube within 48 h, and the patients were allowed to do the passive motion 3 days after the surgery if the X-Ray showed the plate and screws were reliable...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Ji-Yong Kwak, Hyung-Bin Park, Gu-Hee Jung
OBJECTIVES: The purpose of this study was to identify the optimal position for a precontoured-locking plating (PHILOS(®)) of the proximal humerus in Asians in terms of conformity and to determine the prevalence of screw exits in the position of the highest conformity. METHODS: Twenty adult humeri and 14 cadaveric shoulders were included in this study. After placing the precontoured plate in the well-fitted position on the humerus, we measured the distance between the upper margin of the plate and the tip of greater tuberosity (GT) (distance A) and the distance between the anterior margin of the plate and lateral border of the bicipital groove (BG) (distance B)...
October 2016: Archives of Orthopaedic and Trauma Surgery
Amy L Woods, Avish P Sharma, Laura A Garvican-Lewis, Philo Saunders, Tony Rice, Kevin G Thompson
High altitude exposure can increase resting metabolic rate (RMR) and induce weight loss in obese populations, but there is a lack of research regarding RMR in athletes at moderate elevations common to endurance training camps. The present study aimed to determine whether four weeks of classical altitude training affects RMR in middle-distance runners. Ten highly-trained athletes were recruited for four weeks of endurance training undertaking identical programs at either 2200m in Flagstaff, Arizona (ALT, n=5) or 600m in Canberra, Australia (CON, n=5)...
August 24, 2016: International Journal of Sport Nutrition and Exercise Metabolism
Neil Baum, Erich N Brockmann, Kenneth J Lacho
Entrepreneurs are known for opportunity recognition--that is, "How can I start a business to make money from this opportunity?" However, once a commercial entity is formed to take advantage of an opportunity, the leadership priority shifts from entrepreneurial to strategic. A strategic perspective leverages limited resources to position a business for future success relative to rivals in a competitive environment. Often, the talents needed for one priority are not the same as those needed for the other. This article, the first part of a two-part article, intends to simplify the transition from an entrepreneurial to a strategic focus...
May 2016: Journal of Medical Practice Management: MPM
James I Dower, Johanna M Geleijnse, Paul A Kroon, Mark Philo, Marco Mensink, Daan Kromhout, Peter C H Hollman
SCOPE: Cocoa, rich in flavan-3-ols, improves vascular function, but the contribution of specific flavan-3-ols is unknown. We compared the effects of pure epicatechin, a major cocoa flavan-3-ol, and chocolate. METHODS AND RESULTS: In a randomised crossover study, twenty healthy men (40-80 years) were supplemented with: 1) 70g dark chocolate (150 mg epicatechin) with placebo capsules; 2) pure epicatechin capsules (2×50 mg epicatechin) with 75g white chocolate; and 3) placebo capsules with 75g white chocolate (0 mg epicatechin)...
June 22, 2016: Molecular Nutrition & Food Research
Jeffrey Cui, Len Philo, Phirum Nguyen, Heather Hofflich, Carolyn Hernandez, Ricki Bettencourt, Lisa Richards, Joanie Salotti, Archana Bhatt, Jonathan Hooker, William Haufe, Catherine Hooker, David A Brenner, Claude B Sirlin, Rohit Loomba
BACKGROUND & AIMS: Uncontrolled studies show sitagliptin, an oral DPP-4 inhibitor, may improve alanine aminotransferase and liver histology in non-alcoholic fatty liver disease (NAFLD) patients. We aimed to compare sitagliptin vs. the efficacy of a placebo in reducing liver fat measured by MRI-derived proton density-fat fraction (MRI-PDFF). METHODS: This randomized, double-blind, allocation-concealed, placebo-controlled trial included 50 NAFLD patients with prediabetes or early diabetes randomized to sitagliptin orally 100mg/day or placebo for 24weeks...
August 2016: Journal of Hepatology
Victor L Serebruany, Ales Tomek, Yury Pya, Makhabbat Bekbossynova, Moo Hyun Kim
Long-awaiting PHILO trial, conducted in 2011-2012 has been submitted and published late in 2015. In contrast to overall PLATO results, but similar to PLATO-US cohort, PHILO revealed numerical inferiority of ticagrelor with regard to death, myocardial infarction, stroke, and bleeding over clopidogrel. Hence, we comprehend the PHILO results in light of the PLATO-US evidence. To assess the PHILO (n=801) outcomes, applied statistics, and trial conduct, matching them with the PLATO-US (n=1413) patients. The Asian, predominantly Japanese ticagrelor patients had worsened outcomes even when compared to the negative American cohort with regard to death (OR=1...
July 15, 2016: International Journal of Cardiology
Gundolf Schenk, Brad Krajina, Andrew Spakowitz, Sebastian Doniach
In vivo chromosomal behavior is dictated by the organization of genomic DNA at length scales ranging from nanometers to microns. At these disparate scales, the DNA conformation is influenced by a range of proteins that package, twist and disentangle the DNA double helix, leading to a complex hierarchical structure that remains undetermined. Thus, there is a critical need for methods of structural characterization of DNA that can accommodate complex environmental conditions over biologically relevant length scales...
March 30, 2016: Modern Physics Letters. B, Condensed Matter Physics, Statistical Physics, Applied Physics
Alberto Naoki Miyazaki, José Renato Depari Estelles, Marcelo Fregoneze, Pedro Doneux Santos, Luciana Andrade da Silva, Guilherme do Val Sella, Fábio Eduardo Ishioka, João Polydoro Rosa, Sergio Luiz Checchia
OBJECTIVE: To evaluate the complications from surgical treatment using a locking plate among patients with fractures of the proximal extremity of the humerus. METHODS: Between July 2004 and December 2009, 56 patients with fractures of the proximal extremity of the humerus were treated using the PHILOS(®) plate. There were 19 male patients and 37 female patients, with a mean age of 62 years (range: 30 to 92 years). All the cases had a mean postoperative followup period of 12 months...
September 2012: Revista Brasileira de Ortopedia
A Scherf, A Kauffmann, S Kauffmann-Weiss, T Scherer, X Li, F Stein, M Heilmaier
Fe-Al alloys in the aluminium range of 55-65 at.% exhibit a lamellar microstructure of B2-ordered FeAl and triclinic FeAl2, which is caused by a eutectoid decomposition of the high-temperature Fe5Al8 phase, the so-called ∊ phase. The orientation relationship of FeAl and FeAl2 has previously been studied by Bastin et al. [J. Cryst. Growth (1978 ▸), 43, 745] and Hirata et al. [Philos. Mag. Lett. (2008 ▸), 88, 491]. Since both results are based on different crystallographic data regarding FeAl2, the data are re-evaluated with respect to a recent re-determination of the FeAl2 phase provided by Chumak et al...
April 1, 2016: Journal of Applied Crystallography
Stefanie Theuring, Laura F Jefferys, Philo Nchimbi, Paulina Mbezi, Julius Sewangi
In many Sub-Saharan African settings male partner involvement in antenatal care (ANC) remains low, although great benefits for maternal and infant health outcomes have been long recognised, in particular regarding the prevention of HIV transmission. Yet there is paucity on evidence regarding the effectiveness of strategies to increase male partner involvement. This controlled intervention trial in Ruanda Health Centre in Mbeya, Tanzania, assessed the effectiveness of invitation letters for male involvement in ANC...
2016: PloS One
M Kilian, R Zamborský, I Chandoga, M Budaj, S Vajczikova
INTRODUCTION: Proximal humerus fractures account for about 45% of all fractures. Treatment of 3- and 4-part fractures is difficult, and the optimal treatment option remains controversial. The aim of the study was to compare surgical and non-surgical treatments of 3- and 4-part fractures of the proximal humerus in adults. METHOD: A prospective study of surgical and non-surgical treatments of 3- and 4-part fractures of the proximal humerus was conducted at the 2nd Department of Orthopedics and Traumatology, University Hospital Bratislava, from September 2010 until September 2013...
February 2016: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Marcio Cohen, Marcus Vinicius Amaral, Martim Monteiro, Bruno Lobo Brandão, Geraldo Rocha Motta Filho
UNLABELLED: Describe the results of proximal humeral fractures surgically treated with the Philos locking plate system. METHOD: Between March 2003 and October 2004 we prospectively reviewed 24 of 26 patients with proximal humerus fractures treated with a Philos plate. The mean follow-up time was 12 months and the mean age of patients was 57 years. Six patients had four-part proximal humerus fractures, 11 patients had three-part proximal humerus fractures, and nine patients had two-part proximal humerus fractures...
January 2009: Revista Brasileira de Ortopedia
Alexandrina Stirbet, Govindjee
In higher plants, algae, and cyanobacteria, chlorophyll (Chl) a fluorescence induction (ChlFI) has a fast (under a second) increasing OJIP phase and a slow (few minutes) PS(M)T phase, where O is for origin, the minimum fluorescence, J and I for intermediate levels, P for peak, S for a semi-steady state, M for a maximum (which is sometimes missing), and T for the terminal steady-state level. We have used a photosynthesis model of Ebenhöh et al. (Philos Trans R Soc B, 2014, doi: 10.1098/rstb.2013.0223 ) in an attempt to simulate the slow PS(M)T phase and to determine the origin of the S-M rise in Chlamydomonas (C...
March 19, 2016: Photosynthesis Research
Alexander D Shearman, Kyriacos Iordanis Eleftheriou, Akash Patel, Rajib Pradhan, Peter Francis Rosenfeld
Arthrodesis of the ankle and hindfoot in the setting of major deformity is challenging and associated with substantial risks. Patients often have significant comorbidities that lead to unforgiving soft tissues, poor vascularity, and poor bone quality. This creates the high-risk scenario of poor wound healing and poor implant fixation. Complications can be devastating, leading to loss of the limb and sepsis. The use of locking plate technology might provide biomechanical and operative technique advantages in such patients...
May 2016: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
D Fattoretto, A Borgo, C Iacobellis
Complex proximal humerus fractures are often difficult to treat. Their frequency is high, especially in the elderly, and their treatment is still controversial. The aim of this study was to analyze the clinical and radiological results achieved by patients with complex proximal humerus fractures, treated with PHILOS plate only. A cohort of 55 patients was selected. The mean age was 63.4 (range 33-89), while the mean follow-up time was 21.5 months (range 6-75). Clinical outcome was evaluated with the "Constant-Murley shoulder score...
August 2016: Musculoskeletal Surgery
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