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https://www.readbyqxmd.com/read/29094012/managing-extremely-distal-periprosthetic-femoral-supracondylar-fractures-of-total-knee-replacements-a-new-philos-ophy
#1
Kevin J Donnelly, Adam Tucker, Angel Ruiz, Neville W Thompson
We report two cases where a proximal humeral locking plate was used for the fixation of an extremely distal, type III peri-prosthetic femoral fractures in relation to a total knee replacement (TKR). In each case there was concern regarding the fixation that could be achieved using the available anatomic distal femoral plates due to the size and bone quality of distal fragment. The design of the Proximal Humeral Internal Locking System (PHILOS) allows nine 3.5-mm locking screws to be placed over a small area in multiple directions...
October 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28970985/fluoroscopic-technique-for-open-reduction-and-internal-fixation-of-proximal-humeral-fracture-using-the-proximal-humeral-locking-plate-proposal-of-plate-and-screw-views
#2
Wichan Kanchanatawan, Sunikom Suppauksorn, Worawit Densiri-Aksorn, Piyabuth Kittithamvongs, Warongporn Pongpinyopap
Proximal humeral fractures are common injuries with increasing incidence, particularly in the aging population. Nondisplaced or minimally displaced fractures can be treated conservatively whereas surgical fixation is usually indicated in the cases of displaced fractures. Various surgical options have been used for treatment of these fractures. Good outcomes have been reported with use of the Proximal Humeral Internal Locking System (PHILOS plate; Synthes, Zuchwil, Switzerland) as the implant of choice. However many complications have been reported, including varus malalignment, excessive retroversion of the articular part of the humerus, penetration of screws, and avascular necrosis of the humeral head...
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28939999/our-genes-our-selves-hereditary-breast-cancer-and-biological-citizenship-in-norway
#3
Pål Møller, Eivind Hovig
The concept 'hereditary breast cancer' is commonly used to delineate a group of people genetically at risk for breast cancer-all of whom also having risk for other cancers. People carrying pathogenic variants of the BRCA1 and BRCA2 genes are often referred to as those having predisposition for 'hereditary breast cancer'. The two genes, however, are when altered, associated with different risks for and dying from breast cancer. The main risk for dying for carriers of both genes is from ovarian cancer. These biological facts are of philosophical interest, because they are the facts underlying the public debate on BRCA1/2 genetic testing as a model for the discussion of how to implement genetic knowledge and technologies in personalized medicine...
September 22, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28918309/health-and-wellbeing-during-transition-to-adulthood-for-young-people-with-intellectual-disabilities-a-qualitative-study
#4
Genevieve Young-Southward, Sally-Ann Cooper, Christopher Philo
BACKGROUND: Transition to adulthood may have negative consequences for health and wellbeing in individuals with intellectual disabilities (ID), but this aspect of transition has received little investigation. This qualitative study aimed to explore the transition experiences of individuals with ID from their own perspectives, and from that of their parents, in order to identify health or wellbeing implications of transition. METHOD: Semi-structured interviews were conducted with 17 young people with mild, moderate and severe ID aged 16-27 years and with 23 parents of young people with mild, moderate, severe and profound ID aged 16-26 years...
September 14, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28895262/physical-and-mental-health-of-young-people-with-and-without-intellectual-disabilities-cross-sectional-analysis-of-a-whole-country-population
#5
G Young-Southward, E Rydzewska, C Philo, S-A Cooper
BACKGROUND: Transition to adulthood may be a period of vulnerability for health for individuals with intellectual disabilities. No large-scale studies have compared the health of individuals with and without intellectual disabilities undergoing transition. The aims of this study were (1) to compare health during transition for individuals with and without intellectual disabilities across a whole country population and (2) to establish whether transition is associated with health in the population with intellectual disabilities...
October 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28892988/treatment-of-proximal-humerus-fractures-using-philos-plate
#6
Chintan Doshi, Gaurav Mahesh Sharma, Lokesh Gudda Naik, Krishna Sudhakar Badgire, Faisal Qureshi
INTRODUCTION: Treatment of proximal humerus fractures always holds a dilemma for the treating surgeon. AIM: To assess the functional outcome of proximal humerus fractures treated with Proximal Humerus Internal Locking System (PHILOS) plating. MATERIAL AND METHODS: Fifty three consecutive patients were treated with PHILOS plating between August 2013 and August 2014. The inclusion criteria were skeletally matured patients with closed fracture proximal humerus with displacement >1 cm and varus angulation of >45(0)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28845833/early-stage-radiological-critical-analysis-of-unsuccessful-cases-following-a-four-part-fracture-osteosynthesis-of-the-proximal-humerus-focus-on-the-p-sign
#7
Georgios Touloupakis, Wilfried Stuflesser, Fabrizio Ferrara, Alessio Maione, Guido Antonini, Cornelio Crippa
Radiological evaluation of complex intra-articular fractures of the proximal humerus is still challenging. Here, we describe the post-operative "P" sign as a reproducible radiographical mark of a varus reduction, performed by assembling a head-shaft angulation of less than 130 degrees. Our retrospective study was conducted in a group of subjects who previously suffered from proximal humerus four-part fractures. We evaluated the post-operative evolution of specific radiographical parameters that are of crucial prognostic significance: Cervix-diaphysis angle (HHSA), quality level of the orthopaedic reduction (insufficient, sufficient and good) based on a radiological generalized subjective overview, presence of calcar screws through the Philos plate...
August 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28842863/an-analysis-of-waves-underlying-grid-cell-firing-in-the-medial-enthorinal-cortex
#8
Mayte Bonilla-Quintana, Kyle C A Wedgwood, Reuben D O'Dea, Stephen Coombes
Layer II stellate cells in the medial enthorinal cortex (MEC) express hyperpolarisation-activated cyclic-nucleotide-gated (HCN) channels that allow for rebound spiking via an [Formula: see text] current in response to hyperpolarising synaptic input. A computational modelling study by Hasselmo (Philos. Trans. R. Soc. Lond. B, Biol. Sci. 369:20120523, 2013) showed that an inhibitory network of such cells can support periodic travelling waves with a period that is controlled by the dynamics of the [Formula: see text] current...
August 25, 2017: Journal of Mathematical Neuroscience
https://www.readbyqxmd.com/read/28840517/ultimate-and-proximate-explanations-of-strong-reciprocity
#9
Jack Vromen
Strong reciprocity (SR) has recently been subject to heated debate. In this debate, the "West camp" (West et al. in Evol Hum Behav 32(4):231-262, 2011), which is critical of the case for SR, and the "Laland camp" (Laland et al. in Science, 334(6062):1512-1516, 2011, Biol Philos 28(5):719-745, 2013), which is sympathetic to the case of SR, seem to take diametrically opposed positions. The West camp criticizes advocates of SR for conflating proximate and ultimate causation. SR is said to be a proximate mechanism that is put forward by its advocates as an ultimate explanation of human cooperation...
August 23, 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28830630/false-positive-immunoassay-for-acetyl-choline-receptor-antibody-achr-ab-in-patients-exposed-to-polyvalent-antisnake-venom
#10
Kaushik Sundar, Shankar Venkatasubramanian, Sundar Shanmugam, Preetam Arthur, Ramakrishnan Subbaraya, Philo Hazeena
Acute flaccid paralysis is a neuromuscular emergency characterized by rapidly worsening weakness that evolves quickly to cause diaphragmatic failure. The challenge for the treating physician is to stabilize the patient, generate the differential diagnosis and determine the management; all in quick time. Neurotoxic snake bites have inadequate signs of inflammation and are easily missed. Myasthenic crisis, on the other hand, could be the first sign of myasthenia gravis in up to 20% of patients. Both present with acute respiratory failure and inadequate history...
October 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28799364/overview-homogeneous-nucleation-from-the-vapor-phase-the-experimental-science
#11
Barbara E Wyslouzil, Judith Wölk
Homogeneous nucleation from the vapor phase has been a well-defined area of research for ∼120 yr. In this paper, we present an overview of the key experimental and theoretical developments that have made it possible to address some of the fundamental questions first delineated and investigated in C. T. R. Wilson's pioneering paper of 1897 [C. T. R. Wilson, Philos. Trans. R. Soc., A 189, 265-307 (1897)]. We review the principles behind the standard experimental techniques currently used to measure isothermal nucleation rates, and discuss the molecular level information that can be extracted from these measurements...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28738797/tibiotalocalcaneal-ttc-arthrodesis-with-reverse-philos-plate-and-medial-cannulated-screws-with-lateral-approach
#12
Jian Fan, X Zhang, Y Luo, G W You, W K Ng, Y F Yang
BACKGROUND: Tibiotalocalcaneal arthrodesis is most common and effective surgical treatment for severe hindfoot pathology, but the fusion rate is often lower than the ordinary tibiotalar arthrodesis because of the more serious joint disease associated with obvious deformity and osteoporosis. Recent literature describe tibiotalocalcaneal arthrodesis with reverse PHILOS plate with good clinical outcome result, though some patients non-union, due to eccentric force of the plate may be hidden...
July 24, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28716078/cognate-comparative-gene-annotation-characterizer
#13
Jeanne Wilbrandt, Bernhard Misof, Oliver Niehuis
BACKGROUND: The comparison of gene and genome structures across species has the potential to reveal major trends of genome evolution. However, such a comparative approach is currently hampered by a lack of standardization (e.g., Elliott TA, Gregory TR, Philos Trans Royal Soc B: Biol Sci 370:20140331, 2015). For example, testing the hypothesis that the total amount of coding sequences is a reliable measure of potential proteome diversity (Wang M, Kurland CG, Caetano-Anollés G, PNAS 108:11954, 2011) requires the application of standardized definitions of coding sequence and genes to create both comparable and comprehensive data sets and corresponding summary statistics...
July 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28696762/composite-dislocations-in-smectic-liquid-crystals
#14
Hillel Aharoni, Thomas Machon, Randall D Kamien
Smectic liquid crystals are characterized by layers that have a preferred uniform spacing and vanishing curvature in their ground state. Dislocations in smectics play an important role in phase nucleation, layer reorientation, and dynamics. Typically modeled as possessing one line singularity, the layer structure of a dislocation leads to a diverging compression strain as one approaches the defect center, suggesting a large, elastically determined melted core. However, it has been observed that for large charge dislocations, the defect breaks up into two disclinations [C...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28643131/strong-comma-free-codes-in-genetic-information
#15
Elena Fimmel, Christian J Michel, Lutz Strüngmann
Comma-free codes constitute a class of circular codes, which has been widely studied, in particular by Golomb et al. (Biologiske Meddelelser, Kongelige Danske Videnskabernes Selskab 23:1-34, 1958a, Can J Math 10:202-209, 1958b), Michel et al. (Comput Math Appl 55:989-996, 2008a, Theor Comput Sci 401:17-26, 2008b, Inf Comput 212:55-63, 2012), Michel and Pirillo (Int J Comb 2011:659567, 2011), and Fimmel and Strüngmann (J Theor Biol 389:206-213, 2016). Based on a recent approach using graph theory to study circular codes Fimmel et al...
June 22, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28618529/completeness-of-inertial-modes-of-an-incompressible-inviscid-fluid-in-a-corotating-ellipsoid
#16
George Backus, Michel Rieutord
Inertial modes are the eigenmodes of contained rotating fluids restored by the Coriolis force. When the fluid is incompressible, inviscid, and contained in a rigid container, these modes satisfy Poincaré's equation that has the peculiarity of being hyperbolic with boundary conditions. Inertial modes are, therefore, solutions of an ill-posed boundary-value problem. In this paper, we investigate the mathematical side of this problem. We first show that the Poincaré problem can be formulated in the Hilbert space of square-integrable functions, with no hypothesis on the continuity or the differentiability of velocity fields...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28585834/acute-consumption-of-flavan-3-ol-enriched-dark-chocolate-affects-human-endogenous-metabolism
#17
Luisa M Ostertag, Mark Philo, Ian J Colquhoun, Henri S Tapp, Shikha Saha, Garry G Duthie, E Kate Kemsley, Baukje de Roos, Paul A Kroon, Gwénaëlle Le Gall
Flavan-3-ols and methylxanthines have potential beneficial effects on human health including reducing cardiovascular risk. We performed a randomized controlled crossover intervention trial to assess the acute effects of consumption of flavan-3-ol-enriched dark chocolate, compared with standard dark chocolate and white chocolate, on the human metabolome. We assessed the metabolome in urine and blood plasma samples collected before and at 2 and 6 h after consumption of chocolates in 42 healthy volunteers using a nontargeted metabolomics approach...
July 7, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28567159/humeral-tip-apex-distance-as-a-prognostic-marker-for-proximal-humeral-fractures-in-203-patients
#18
Dominik Saul, Tobias Himmelmann, Klaus Dresing
BACKGROUND: Humeral head fractures and their postoperative outcome remain a challenging problem in surgical daily routine. Predictive factors for loss of fixation are rare. OBJECTIVE: Determination of predictive factors for the failure of osteosynthesis with the loss of fixation or migration of screws in humeral head fractures. METHOD: From 1995 to 2011, 408 patients with proximal humeral fractures [mean age 66.6 years, 50.9-82.3 years] and osteosynthesis were analyzed...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28523552/epigenetics-of-huntington-s-disease
#19
REVIEW
Silvia Bassi, Takshashila Tripathi, Alan Monziani, Francesca Di Leva, Marta Biagioli
Huntington's disease (HD) is a genetic, fatal autosomal dominant neurodegenerative disorder typically occurring in midlife with symptoms ranging from chorea, to dementia, to personality disturbances (Philos Trans R Soc Lond Ser B Biol Sci 354:957-961, 1999). HD is inherited in a dominant fashion, and the underlying mutation in all cases is a CAG trinucleotide repeat expansion within exon 1 of the HD gene (Cell 72:971-983, 1993). The expanded CAG repeat, translated into a lengthened glutamine tract at the amino terminus of the huntingtin protein, affects its structural properties and functional activities...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28432516/the-tower-of-london-tol-in-italy-standardization-of-the-tol-test-in-an-italian-population
#20
Maddalena Boccia, Dario Marin, Giovanni D'Antuono, Paola Ciurli, Chiara Incoccia, Gabriella Antonucci, Cecilia Guariglia, Laura Piccardi
Deficit in planning and problem-solving, affecting a wide range of neuropsychological patients, has been widely investigated using the Tower of London (ToL) test, as developed by Shallice (Philos Trans R Soc Lond Ser B Biol Sci 298:199-209, 1). The ToL taps on several executive functions (EF), such as planning, time for planning or rule breaks, which may be usefully indexed by different ToL measurements. However, in its original version, the different aspects involved in ToL are not evaluated in a specific way...
July 2017: Neurological Sciences
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