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https://www.readbyqxmd.com/read/29344161/uvb-radiation-represses-cyld-expression-in-melanocytes
#1
Silke Kuphal, Nadja Schneider, Ramin Massoumi, Claus Hellerbrand, Anja Katrin Bosserhoff
CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B-cell lymphoma-3/p50/p52-dependent nuclear factor-κB activation, which in turn triggers the expression of genes such as cyclin D1 and N-cadherin...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343685/the-protective-role-of-dot1l-in-uv-induced-melanomagenesis
#2
Bo Zhu, Shuyang Chen, Hongshen Wang, Chengqian Yin, Changpeng Han, Cong Peng, Zhaoqian Liu, Lixin Wan, Xiaoyang Zhang, Jie Zhang, Christine G Lian, Peilin Ma, Zhi-Xiang Xu, Sharon Prince, Tao Wang, Xiumei Gao, Yujiang Shi, Dali Liu, Min Liu, Wenyi Wei, Zhi Wei, Jingxuan Pan, Yongjun Wang, Zhenyu Xuan, Jay Hess, Nicholas K Hayward, Colin R Goding, Xiang Chen, Jun Zhou, Rutao Cui
The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis. Here, we demonstrate that, in contrast to MLL-rearranged leukemia, DOT1L plays a protective role in ultraviolet radiation (UVR)-induced melanoma development. Specifically, the DOT1L gene is located in a frequently deleted region and undergoes somatic mutation in human melanoma. Specific mutations functionally compromise DOT1L methyltransferase enzyme activity leading to reduced H3K79 methylation...
January 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29341894/protective-effects-of-antioxidin-rl-from-odorrana-livida-against-ultraviolet-b-irradiated-skin-photoaging
#3
Di Qin, Wen-Hui Lee, Zhiqin Gao, Weifen Zhang, Meiyu Peng, Tongyi Sun, Yuanyuan Gao
The unavoidable daily exposure of the skin to ultraviolet (UV) B radiation is proven to have deleterious effects. The action mechanism of antioxidin-RL, an antioxidant peptide purified from skin secretions of frog Odorrana livida with amino acid sequence of AMRLTYNRPCIYAT, is well characterized by NMR titration and mutation based on ABTS+ scavenging activities. In order to explore the protective effects of antioxidin-RL against UVB-irradiated skin photoaging, cell uptake assay was used to detect the location of antioxidin-RL molecules serving various biological functions in the cells...
January 13, 2018: Peptides
https://www.readbyqxmd.com/read/29340384/kinetics-of-the-a-c3h5-o2-reaction-investigated-by-photoionization-using-synchrotron-radiation
#4
D Schleier, P Constantinidis, N Faßheber, I Fischer, G Friedrichs, P Hemberger, E Reusch, B Sztáray, K Voronova
The kinetics of the combustion-relevant reaction of the allyl radical, a-C3H5, with molecular oxygen has been studied in a flow tube reactor at the vacuum ultraviolet (VUV) beamline of the Swiss Light Source storage ring, using the CRF-PEPICO (Combustion Reactions Followed by Photoelectron Photoion Coincidence Spectroscopy) setup. The ability to measure threshold photoelectron spectra enables a background-free detection of reactive species as well as an isomer-specific analysis of reaction products. Allyl was generated by direct photodissociation of allyl iodide at 266 nm and 213 nm and indirectly by the reaction of propene with Cl atoms, which were generated by photolysis from oxalyl chloride at 266 nm...
January 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29339305/modelling-ros-formation-in-boreal-lakes-from-interactions-between-dissolved-organic-matter-and-absorbed-solar-photon-flux
#5
Raoul Wolf, Jan-Erik Thrane, Dag Olav Hessen, Tom Andersen
Concentrations of dissolved organic matter (DOM) are increasing in a large number of lakes across the Northern hemisphere. This browning serves a dual role for biota by protecting against harmful ultraviolet radiation, while also absorbing photosynthetically active radiation. The photochemical activation of DOM and subsequent formation of reactive oxygen species (ROS) is a potentially harmful side effect, but can be difficult to measure directly in situ. In this study, we combine a data set of physico-chemical properties from 71 Nordic lakes with in vitro ROS formation quantum yields to predict ROS formations across a representative boreal ecosystem gradient...
January 11, 2018: Water Research
https://www.readbyqxmd.com/read/29339217/effects-of-rutin-on-the-physicochemical-properties-of-skin-fibroblasts-membrane-disruption-following-uv-radiation
#6
Izabela Dobrzyńska, Agnieszka Gęgotek, Ewelina Gajko, Elżbieta Skrzydlewska, Zbigniew A Figaszewski
Human skin provides the body's first line of defense against physical and environmental assaults. This study sought to determine how rutin affects the membrane electrical properties, sialic acid content, and lipid peroxidation levels of fibroblast membranes after disruption by ultraviolet (UV) radiation. Changes in cell function may affect the basal electrical surface properties of cell membranes, and changes can be detected by electrokinetic measurements. The charge density of the fibroblast membrane surface was measured as a function of pH...
January 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29338879/identifying-lost-surgical-needles-with-visible-and-near-infrared-fluorescent-light-emitting-microscale-coating
#7
Erin P Ward, Jian Yang, Jonathan C Delong, Tsai-Wen Sung, James Wang, Chris Barback, Natalie Mendez, Santiago Horgan, William Trogler, Andrew C Kummel, Sarah L Blair
BACKGROUND: Retained foreign bodies (RFOs) have substantial clinical and financial consequences. In laparoscopic surgery, RFOs can be a cause of needing to convert a minimally invasive surgery (MIS) procedure to an open operation. A coating for surgical models was developed to augment localization of needles using fluorescence appropriate for open and minimally invasive surgeries procedures. METHODS: An epoxy matrix containing both dansyl chloride and indocyanine green was coated as visible and near infrared labels, respectively...
January 12, 2018: Surgery
https://www.readbyqxmd.com/read/29336831/ultraviolet-radiation-significantly-enhances-the-molecular-response-to-dispersant-and-sweet-crude-oil-exposure-in-nematostella-vectensis
#8
Ann M Tarrant, Samantha L Payton, Adam M Reitzel, Danielle T Porter, Matthew J Jenny
Estuarine organisms are subjected to combinations of anthropogenic and natural stressors, which together can reduce an organisms' ability to respond to either stress or can potentiate or synergize the cellular impacts for individual stressors. Nematostella vectensis (starlet sea anemone) is a useful model for investigating novel and evolutionarily conserved cellular and molecular responses to environmental stress. Using RNA-seq, we assessed global changes in gene expression in Nematostella in response to dispersant and/or sweet crude oil exposure alone or combined with ultraviolet radiation (UV)...
January 4, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29328978/sun-behaviour-on-the-beach-monitored-by-webcam-photos
#9
I M Heerfordt, P A Philipsen, H C Wulf
OBJECTIVES: To prevent skin cancer, the general population is recommended to limit time in the sun, to wear clothes and to seek shade around noon. This study aimed to investigate the number of beachgoers, the duration of sun exposure, and clothing worn during the day on a beach in Copenhagen. STUDY DESIGN: Observational, descriptive study. METHODS: On 11 beach days in 2014 and 2015, beachgoers were counted every hour from 8:00 to 20:00. It was noted if they wore clothes or swimwear...
January 9, 2018: Public Health
https://www.readbyqxmd.com/read/29328366/expression-of-dna-damage-response-proteins-in-gastric-cancer-comprehensive-protein-profiling-and-histological-analysis
#10
Hiroki Arai, Ryuichi Wada, Kousuke Ishino, Mitsuhiro Kudo, Eiji Uchida, Zenya Naito
Gastric cancer is the third major cause of cancer-related mortality in Japan. The aim of this study was to identify a factor implicated in the biology of gastric cancer by comprehensive protein profiling. Protein profiling was carried out by liquid chromatography-tandem mass spectrometry, using formalin-fixed paraffin-embedded specimens of 17 gastric cancer cases. Pathway analysis and orthogonal partial least square-discriminant analysis suggested the significant expression of ribonucleoproteins, heterogeneous nuclear ribonucleoproteins, interleukin binding factor 2 (ILF2), KU70 and KU80, which are involved in DNA damage response (DDR)...
January 5, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29324843/beta-hpv38-oncoproteins-act-with-a-hit-and-run-mechanism-in-ultraviolet-radiation-induced-skin-carcinogenesis-in-mice
#11
Daniele Viarisio, Karin Müller-Decker, Rosita Accardi, Alexis Robitaille, Matthias Dürst, Katrin Beer, Lars Jansen, Christa Flechtenmacher, Matthias Bozza, Richard Harbottle, Catherine Voegele, Maude Ardin, Jiri Zavadil, Sandra Caldeira, Lutz Gissmann, Massimo Tommasino
Cutaneous beta human papillomavirus (HPV) types are suspected to be involved, together with ultraviolet (UV) radiation, in the development of non-melanoma skin cancer (NMSC). Studies in in vitro and in vivo experimental models have highlighted the transforming properties of beta HPV E6 and E7 oncoproteins. However, epidemiological findings indicate that beta HPV types may be required only at an initial stage of carcinogenesis, and may become dispensable after full establishment of NMSC. Here, we further investigate the potential role of beta HPVs in NMSC using a Cre-loxP-based transgenic (Tg) mouse model that expresses beta HPV38 E6 and E7 oncogenes in the basal layer of the skin epidermis and is highly susceptible to UV-induced carcinogenesis...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29324427/lemons-in-the-arizona-sunshine-the-effects-of-furocoumarins-leading-to-phytophotodermatitis-and-burn-like-injuries
#12
Marc R Matthews, Joel C VanderVelde, Daniel M Caruso, Kevin N Foster
INTRODUCTION: Phytophototoxic dermatitis is a strong phototoxic reaction to ultraviolet A (UV-A) radiation exposure after cutaneous contact with citrus fruit containing furocoumarins, leading to skin injury. At the Arizona Burn Center (Phoenix, AZ), the majority of these injuries are managed in the outpatient setting. CASE REPORT: The authors present a pediatric admission for burn-like injuries following prolonged cutaneous exposure to lemons while playing in the Arizona sunshine...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29323733/photo-induced-toxicity-following-exposure-to-crude-oil-and-ultraviolet-radiation-in-two-australian-fishes
#13
Lauren E Sweet, Andrew T Revill, Joanna Strzelecki, Sharon E Hook, Jeffrey M Morris, Aaron P Roberts
Some polycyclic aromatic hydrocarbons (PAHs), a component of crude oil, are known to cause increased toxicity when organisms are co-exposed with ultraviolet radiation, resulting in photo-induced toxicity. The photodynamic characteristic of some PAHs are of particular concern to places like Australia with high ultraviolet radiation levels. The objective of this study was to characterize the photo-induced toxicity of an Australian Northwest Shelf oil to early life stage yellowtail kingfish (Seriola lalandi) and black bream (Acanthopagrus butcheri)...
January 11, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29323251/vitamin-e-inhibits-the-uvai-induction-of-light-and-dark-cyclobutane-pyrimidine-dimers-and-oxidatively-generated-dna-damage-in-keratinocytes
#14
George J Delinasios, Mahsa Karbaschi, Marcus S Cooke, Antony R Young
Solar ultraviolet radiation (UVR)-induced DNA damage has acute, and long-term adverse effects in the skin. This damage arises directly by absorption of UVR, and indirectly via photosensitization reactions. The aim of the present study was to assess the effects of vitamin E on UVAI-induced DNA damage in keratinocytes in vitro. Incubation with vitamin E before UVAI exposure decreased the formation of oxidized purines (with a decrease in intracellular oxidizing species), and cyclobutane pyrimidine dimers (CPD)...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321610/physiological-effects-of-short-acute-uvb-treatments-in-chenopodium-quinoa-willd
#15
Thais Huarancca Reyes, Andrea Scartazza, Antonella Castagna, Eric G Cosio, Annamaria Ranieri, Lorenzo Guglielminetti
Increased ultraviolet B (UVB) radiation due to global change can affect plant growth and metabolism. Here, we evaluated the capacity of quinoa to resist under short acute UVB irradiation. Quinoa was daily exposed for 30 or 60 min to 1.69 W m-2 UVB. The results showed that 30 min exposure in 9 d-course did not cause severe alterations on photosynthetic pigments and flavonoids, but a significant increase of antioxidant capacity was observed. Otherwise, 60 min UVB in 5 d-course reduced almost all these parameters except for an increase in the de-epoxidation of xanthophyll cycle pigments and led to the death of the plants...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318223/investigating-isomer-specific-photoprotection-in-a-model-plant-sunscreen
#16
M D Horbury, A L Flourat, S E Greenough, F Allais, V G Stavros
Sinapate esters are used throughout the plant kingdom, for example in photoprotection from ultraviolet radiation. Sinapate esters are naturally produced in their E-isomeric form; however, upon exposure to ultraviolet radiation, photoisomerization drives Z-isomer formation. To elucidate the photoprotection capacity of E vs. Z forms of sinapate esters, we explore the photochemistry of the model system, Z-ethyl sinapate. Following a novel Z-ethyl sinapate synthesis, we demonstrate that photoprotection is isomer independent...
January 10, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29317335/integrated-case-control-and-somatic-germline-interaction-analyses-of-melanoma-susceptibility-genes
#17
Yao Yu, Hao Hu, Jiun-Sheng Chen, Fulan Hu, Jerry Fowler, Paul Scheet, Hua Zhao, Chad D Huff
While a number of genes have been implicated in melanoma susceptibility, the role of protein-coding variation in melanoma development and progression remains underexplored. To better characterize the role of germline coding variation in melanoma, we conducted a whole-exome case-control and somatic-germline interaction study involving 322 skin cutaneous melanoma cases from The Cancer Genome Atlas and 3607 controls of European ancestry. We controlled for cross-platform technological stratification using XPAT and conducted gene-based association tests using VAAST 2...
January 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29316160/luminescence-properties-of-tm3-ions-single-doped-yf3-materials-in-an-unconventional-excitation-region
#18
Yuan Chen, Qing Liu, Han Lin, Xiaohong Yan
According to the spectral distribution of solar radiation at the earth's surface, under the excitation region of 1150 to 1350 nm, the up-conversion luminescence of Tm3+ ions was investigated. The emission bands were matched well with the spectral response region of silicon solar cells, achieved by Tm3+ ions single-doped yttrium fluoride (YF3 ) phosphor, which was different from the conventional Tm3+ /Yb3+ ion couple co-doped materials. Additionally, the similar emission bands of Tm3+ ions were achieved under excitation in the ultraviolet region...
January 9, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29315607/the-solar-ultraviolet-environment-at-the-ocean
#19
Curtis D Mobley, Brian L Diffey
Atmospheric and oceanic radiative transfer models were used to compute spectral radiances between 285 and 400 nm onto horizontal and vertical plane surfaces over water. The calculations kept track of the contributions by the sun's direct beam, by diffuse sky radiance, by radiance reflected from the sea surface, and by water-leaving radiance. Clear, hazy, and cloudy sky conditions were simulated for a range of sun zenith angles, wind speeds, and atmospheric ozone concentrations. The radiances were used to estimate erythemal exposures due to the sun and sky, as well as from radiation reflected by the sea surface and backscattered from the water column...
January 8, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29313597/vitamin-d-and-vitamin-d-receptor-in-patients-with-ophthalmic-pterygium
#20
Cristina Maxia, Daniela Murtas, Michela Corrias, Ignazio Zucca, Luigi Minerba, Franca Piras, Cristiana Marinelli, Maria Teresa Perra
Pterygium, an ultraviolet radiation (UV)-related disease, is a relatively benign process, but since it displays tumor-like features, it has been proposed to be a neoplastic- like growth disorder. Vitamin D performs a number of functions in addition to calcium homeostasis, as inhibition of cell proliferation, activation of apoptotic pathways, and inhibition of angiogenesis. Since the antitumor actions of vitamin D are mediated primarily through the nuclear vitamin D receptor (VDR), the aim of the present study was to investigate vitamin D status in patients with pterygium and in control subjects, and VDR immunohistochemical expression in samples of pterygium and normal conjunctiva in order to evaluate a possible role of vitamin D pathway in the pathogenesis of the disease...
October 30, 2017: European Journal of Histochemistry: EJH
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