keyword
MENU ▼
Read by QxMD icon Read
search

Ultraviolet radiation

keyword
https://www.readbyqxmd.com/read/29786078/targeting-the-upstream-transcriptional-activator-of-pd-l1-as-an-alternative-strategy-in-melanoma-therapy
#1
Bo Zhu, Liming Tang, Shuyang Chen, Chengqian Yin, Shiguang Peng, Xin Li, Tongzheng Liu, Wei Liu, Changpeng Han, Lukasz Stawski, Zhi-Xiang Xu, Guangbiao Zhou, Xiang Chen, Xiumei Gao, Colin R Goding, Nan Xu, Rutao Cui, Peng Cao
Programmed cell death ligand 1 (PD-L1) interacts with programmed cell death protein-1 (PD-1) as an immune checkpoint. Reactivating the immune response by inhibiting PD-L1 using therapeutic antibodies provides substantial clinical benefits in many, though not all, melanoma patients. However, transcriptional suppression of PD-L1 expression as an alternative therapeutic anti-melanoma strategy has not been exploited. Here we provide biochemical evidence demonstrating that ultraviolet radiation (UVR) induction of PD-L1 in skin is directly controlled by nuclear factor E2-related transcription factor 2 (NRF2)...
May 22, 2018: Oncogene
https://www.readbyqxmd.com/read/29780610/a-randomised-controlled-clinical-trial-of-narrowband-uvb-phototherapy-for-clinically-isolated-syndrome-the-phocis-study
#2
Prue H Hart, Anderson P Jones, Stephanie Trend, Lilian Cha, Marzena J Fabis-Pedrini, Matthew N Cooper, Catherine d'Este, Sian Geldenhuys, William M Carroll, Scott N Byrne, David R Booth, Judith M Cole, Robyn M Lucas, Allan G Kermode
Background: The natural history of multiple sclerosis (MS) typically presents with the clinically isolated syndrome (CIS), an episode of neurological symptoms caused by central nervous system inflammation or demyelination that does not fulfil the diagnostic criteria for MS. Objective: As preclinical studies have suggested that exposure to ultraviolet radiation (UVR) could regulate the development of MS, the Phototherapy for CIS (PhoCIS trial) was established to examine the effects of narrowband UVB phototherapy on patients with CIS, and their conversion to MS...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29779986/photodynamic-therapy-corrects-abnormal-cancer-associated-gene-expression-observed-in-actinic-keratosis-lesions-and-induces-a-remodeling-effect-in-photodamaged-skin
#3
Florence Joly, Sophie Deret, Bastien Gamboa, Corinne Menigot, Paul Fogel, Carine Mounier, Pascale Reiniche, Farzaneh Sidou, Jérome Aubert, John Lear, Anthony A Fryer, Francesca Zolezzi, Johannes J Voegel
BACKGROUND: Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant Recipients (OTR) have an increased risk of developing SCC as a consequence of long-term immunosuppressive therapy. The aim of this study was to determine the molecular signature of AKs from OTR prior to treatment with methyl aminolevulinate-photodynamic therapy (MAL-PDT), and to assess what impact the treatment has on promoting remodeling of the photo-damaged skin...
May 17, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29779004/cancer-incidence-among-merchant-seafarers-an-extended-follow-up-of-a-danish-cohort
#4
Kajsa Ugelvig Petersen, Julie Volk, Linda Kaerlev, Henrik Lyngbeck Hansen, Johnni Hansen
OBJECTIVES: While maritime safety generally has improved dramatically over the last century, modern seafarers are still faced with numerous occupational hazards potentially affecting their risk of chronic diseases such as cancer. The aim of this study is to offer updated information on the incidence of specific cancers among both male and female seafarers. METHODS: Using records from the Danish Seafarer Registry, all seafarers employed on Danish ships during 1986-1999 were identified, resulting in a cohort of 33 084 men and 11 209 women...
May 19, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29777583/predicting-phototoxicity-of-alkylated-pahs-pahs-mixtures-and-water-accommodated-fractions-of-neat-and-weathered-petroleum-with-the-phototoxic-target-lipid-model
#5
Solmaz Marzooghi, Bryson E Finch, William A Stubblefield, Dominic M Di Toro
The toxicity of petroleum can increase considerably when exposed to solar radiation. It occurs when certain components in the mixture, including polycyclic aromatic hydrocarbons (PAHs), absorb light in ultraviolet and visible portions of the solar radiation spectrum. A phototoxic target lipid model (PTLM), previously developed to predict phototoxicity of single PAHs, is validated for four species: Americamysis bahia, Rhepoxynius abronius, Daphnia magna, and Pimephales promelas exposed to 12 compounds that are components of petroleum, including alkylated PAHs and dibenzothiophene...
May 19, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29774387/ultraviolet-radiation-induces-melan-a-expressing-cells-in-interfollicular-epidermis-in-wild-type-mice
#6
David A De Luca, Barbara Sterniczky, Susanne Kimeswenger, Dagmar Födinger, Agatha Schwarz, Thomas Schwarz, Christian Jantschitsch
Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated mouse models used for melanoma research limitations, including an altered immune system and selection of affected pathways, lead to tumors phenotypically quite different from naturally occurring melanomas. We compared the distribution of epidermal melanocytes in UVR and not-UVR-exposed wild-type C57BL/6 mice...
May 17, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29773811/coherent-control-schemes-for-the-photoionization-of-neon-and-helium-in-the-extreme-ultraviolet-spectral-region
#7
Luca Giannessi, Enrico Allaria, Kevin C Prince, Carlo Callegari, Giuseppe Sansone, Kiyoshi Ueda, Toru Morishita, Chien Nan Liu, Alexei N Grum-Grzhimailo, Elena V Gryzlova, Nicolas Douguet, Klaus Bartschat
The seeded Free-Electron Laser (FEL) FERMI is the first source of short-wavelength light possessing the full coherence of optical lasers, together with the extreme power available from FELs. FERMI provides longitudinally coherent radiation in the Extreme Ultraviolet and soft x-ray spectral regions, and therefore opens up wide new fields of investigation in physics. We first propose experiments exploiting this property to provide coherent control of the photoionization of neon and helium, carry out numerical calculations to find optimum experimental parameters, and then describe how these experiments may be realized...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768722/genoprotective-effect-of-phyllanthus-orbicularis-extract-against-uva-uvb-and-solar-radiation
#8
Marioly Vernhes Tamayo, André Passaglia Schuch, Teiti Yagura, Luis Baly Gil, Carlos Frederico Martins Menck, Angel Sánchez-Lamar
One approach to protect the human skin against harmful effects of solar ultraviolet (UV) radiation is to use natural products as photoprotectors. In this work, the extract from specie Phyllanthus orbicularis K was evaluated as a protective agent against the photodamage by UVB, UVA artificial lamps and environmental sunlight exposure. The plasmid DNA solutions were exposed to radiations using the DNA-dosimeter system in presence of plant extract. The DNA repair enzymes, E. coli Formamidopyrimidine-DNA glycosylase (Fpg) and T4 bacteriophage endonuclease V (T4-endo V), were employed to discriminate oxidized DNA damage and cyclobutane pyrimidine dimers (CPD) respectively...
May 16, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29764149/vacuum-ultraviolet-photoionization-cross-section-of-the-hydroxyl-radical
#9
Leah G Dodson, John D Savee, Samer Gozem, Linhan Shen, Anna I Krylov, Craig A Taatjes, David L Osborn, Mitchio Okumura
The absolute photoionization spectrum of the hydroxyl (OH) radical from 12.513 to 14.213 eV was measured by multiplexed photoionization mass spectrometry with time-resolved radical kinetics. Tunable vacuum ultraviolet (VUV) synchrotron radiation was generated at the Advanced Light Source. OH radicals were generated from the reaction of O(1 D) + H2 O in a flow reactor in He at 8 Torr. The initial O(1 D) concentration, where the atom was formed by pulsed laser photolysis of ozone, was determined from the measured depletion of a known concentration of ozone...
May 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29763564/inhibitors-of-melanogenesis-an-updated-review
#10
Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Manoj Manickam, Sang Hun Jung
Melanins are pigment molecules that determine the skin, eye, and hair color of the human subject to its amount, quality and distribution. Melanocytes synthesize melanin and provide epidermal protection from various stimuli, such as harmful ultraviolet radiation, through the complex process called melanogenesis. However, a serious dermatological problems occur when the excessive production of melanin in different parts of the human body. These include freckles, melasma, senile lentigo, pigmented acne scars and cancer...
May 15, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29761935/the-application-of-transcriptional-benchmark-dose-modeling-for-deriving-thresholds-of-effects-associated-with-solar-simulated-ultraviolet-radiation-exposure
#11
Sami S Qutob, Vinita Chauhan, Byron Kuo, Andrew Williams, Carole L Yauk, James P McNamee, B Gollapudi
Considerable data has been generated to elucidate the transcriptional response of cells to ultraviolet radiation (UVR) exposure providing a mechanistic understanding of UVR-induced cellular responses. However, using these data to support standards development has been challenging. In this study, we apply benchmark dose (BMD) modeling of transcriptional data to derive thresholds of gene responsiveness following exposure to solar-simulated UVR. Human epidermal keratinocytes were exposed to three doses (10, 20, 150 kJ/m2 ) of solar simulated UVR and assessed for gene expression changes 6 and 24 hr postexposure...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29761305/uv-b-susceptibility-and-photoreactivation-in-embryonic-development-of-the-two-spotted-spider-mite-tetranychus-urticae
#12
Yoshio Yoshioka, Tetsuo Gotoh, Takeshi Suzuki
Developmental errors are often induced in the embryos of many organisms by environmental stress. Ultraviolet-B radiation (UV-B) is one of the most serious environmental stressors in embryonic development. Here, we investigated susceptibility to UV-B (0.5 kJ m-2 ) in embryos of the two-spotted spider mite, Tetranychus urticae, to examine the potential use of UV-B in control of this important agricultural pest worldwide. Peak susceptibility to UV-B (0% hatchability) was found in T. urticae eggs 36-48 h after oviposition at 25 °C, which coincides with the stages of morphogenesis forming the germ band and initial limb primordia...
May 14, 2018: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29758545/protection-against-uv-induced-oxidative-stress-and-dna-damage-by-amazon-moss-extracts
#13
A S Fernandes, J L Mazzei, H Evangelista, M R C Marques, E R A Ferraz, I Felzenszwalb
Amazon mosses, such as Holomitriopsis laevifolia and Leucobryum sp. are naturally exposed to high levels of solar ultraviolet (UV) radiation. Theoretically, under environmental stress conditions these mosses have developed protective chemical and metabolic strategies against UV damage, by way of biosynthesis of secondary metabolites, such as flavonoids. The present paper aimed to evaluate the free-radical scavenging activity, and the photoprotective, mutagenic and photomutagenic potencies of the methanolic (ME), aqueous (AE), hydroalcoholic (HE), ethanolic (EE) extracts of H...
April 27, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29757234/effect-of-uvc-radiation-on-hydrated-and-desiccated-cultures-of-slightly-halophilic-and-non-halophilic-methanogenic-archaea-implications-for-life-on-mars
#14
Navita Sinha, Timothy A Kral
Methanogens have been considered models for life on Mars for many years. In order to survive any exposure at the surface of Mars, methanogens would have to endure Martian UVC radiation. In this research, we irradiated hydrated and desiccated cultures of slightly halophilic Methanococcus maripaludis and non-halophilic Methanobacterium formicicum for various time intervals with UVC (254 nm) radiation. The survivability of the methanogens was determined by measuring methane concentrations in the headspace gas samples of culture tubes after re-inoculation of the methanogens into their growth-supporting media following exposure to UVC radiation...
May 12, 2018: Microorganisms
https://www.readbyqxmd.com/read/29755205/enumerating-viable-phytoplankton-using-a-culture-based-most-probable-number-assay-following-ultraviolet-c-treatment
#15
Hugh L MacIntyre, John J Cullen, Trina J Whitsitt, Brian Petri
Ballast water management systems (BWMS) must be tested to assess their compliance with standards for the discharge of organisms, for example in the ≥ 10- and < 50-μm size category, which is dominated by phytoplankton. Assessment of BWMS performance with the vital stains fluorescein diacetate + 5-chlorofluorescein diacetate, required by regulations in the USA, is problematic in the case of ultraviolet-C (UVC) radiation. This is because UVC targets nucleotides-and thus reproduction, hence viability-rather than membrane integrity, which is assayed by the stains...
2018: Journal of Applied Phycology
https://www.readbyqxmd.com/read/29754196/painful-stimulation-of-a-sensitized-site-in-the-forearm-inhibits-ipsilateral-trigeminal-nociceptive-blink-reflexes
#16
Peter D Drummond, Ashlea Bell, Lechi Vo
Exposure to moderate levels of ultraviolet B radiation (UVB) is painless but nevertheless induces an inflammatory response that sensitizes primary afferent nociceptors. Subsequently, heating the UVB-treated site can sensitize spinal nociceptors. We used a repeated-measures design to determine whether heating the UVB-treated site also triggers ipsilateral inhibitory controls. Specifically, a 2-cm diameter site on the forearm of 20 participants was exposed to UVB at twice the minimum erythema dose. 48 h later mechanical and thermal sensitivity had increased at the UVB-treated site, indicating primary hyperalgesia...
May 12, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29752876/quantifying-direct-dna-damage-in-the-basal-layer-of-skin-exposed-to-uv-radiation-from-sunbeds
#17
Isla Rose Mary Barnard, Patrick Tierney, Catherine Louise Campbell, Lewis McMillan, Harry Moseley, Ewan Eadie, Christian Tom Alcuin Brown, Kenneth Wood
Non-melanoma and melanoma skin cancers are attributable to DNA damage caused by ultraviolet (UV) radiation exposure. One DNA photoproduct, the Cyclobutane Pyrimidine Dimer (CPD), is believed to lead to DNA mutations caused by UV radiation. Using radiative transfer simulations, we compare the number of CPDs directly induced by UV irradiation from artificial and natural UV sources (a standard sunbed and the midday summer Mediterranean sun) for skin types I and II on the Fitzpatrick scale. We use Monte Carlo Radiative Transfer (MCRT) modelling to track the progression of UV photons through a multi-layered three dimensional (3D) grid that simulates the upper layers of the skin...
May 12, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29751729/unravelling-the-photoprotection-properties-of-mycosporine-amino-acid-motifs
#18
Jack Matthew Woolley, Michael Staniforth, Michael D Horbury, Gareth W Richings, Martin Wills, Vasilios G Stavros
Photoprotection from harmful ultraviolet (UV) radiation exposure is a key problem in modern society. Mycosporine like amino acids found in fungi, cyanobacteria, macroalgae, phytoplankton and humans, are already presenting a promising form of natural photoprotection in sunscreen formulations. Using time-resolved transient electronic absorption spectroscopy and guided by complementary ab initio calculations, we help to unravel how the core structures of these molecules perform under UV irradiation. Through such detailed insight into the relaxation mechanisms of these ubiquitous molecules, we hope to inspire new thinking in developing next generation sun protecting molecules...
May 11, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29750411/effect-of-uv-b-irradiation-on-water-suspended-metarhizium-anisopliae-s-l-hypocreales-clavicipitaceae-conidia-and-their-larvicidal-activity-in-aedes-aegypti-diptera-culicidae
#19
Marianel L Falvo, Patricia Albornoz Medina, Juscelino Rodrigues, Claudia C López Lastra, Juan J García, Éverton K K Fernandes, Christian Luz
Ultraviolet (UV) radiation is a key limiting factor for biological pest control with entomopathogenic fungi. While little is known about the impact of UV on Metarhizium anisopliae Metchnikoff (Sorokin) (Hypocreales: Clavicipitaceae) conidia in aquatic mosquito-breeding sites, this study determined the effect of UV-B on the viability and virulence of M. anisopliae sensu lato (s.l.) strain IP 46 in the laboratory against Aedes aegypti (L.) (Diptera: Culicidae) larvae. Conidia were treated in cups under defined water depths (0, 1, 2, and 3 cm) to six different UV-B doses (0, 0...
May 10, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29748690/untargeted-lipidomic-analysis-of-primary-human-epidermal-melanocytes-acutely-and-chronically-exposed-to-uv-radiation
#20
Núria Dalmau, Nathalie Andrieu-Abadie, Romà Tauler, Carmen Bedia
Ultraviolet (UV) radiation present in sunlight has been related to harmful effects on skin such as premature aging and skin cancer. In order to study the effects of UV radiation on skin, many investigations have been carried out at transcriptomic and proteomic levels. However, studies on the effects of UV radiation on lipid composition are scarce. In this work, primary cultures of melanocytes were exposed to UV radiation in a similar UVA/UVB ratio to that found in solar light. The UV exposure was carried out twice a week and different endpoints were investigated at 0...
May 11, 2018: Molecular omics
keyword
keyword
113806
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"