keyword
https://read.qxmd.com/read/38522427/fractional-excretion-of-urea-nitrogen-can-identify-true-worsening-renal-function-in-patients-with-heart-failure
#1
JOURNAL ARTICLE
Yukihiro Watanabe, Yoshiaki Kubota, Takuya Nishino, Shuhei Tara, Katsuhito Kato, Daisuke Hayashi, Junya Matsuda, Hideki Miyachi, Yukichi Tokita, Yu-Ki Iwasaki, Kuniya Asai
AIMS: Fractional excretion of urea nitrogen (FEUN), used to differentiate the cause of acute kidney injury, has emerged as a useful fluid index in patients with heart failure (HF). We hypothesized that FEUN could be useful in identifying worsening renal function (WRF) associated with poor outcomes in patients with acute HF (AHF). METHODS AND RESULTS: Overall, 1103 patients with AHF (median age, 78 years; male proportion, 60%) were categorized into six groups according to the presence of WRF and FEUN values (low, ≤32...
March 24, 2024: ESC Heart Failure
https://read.qxmd.com/read/38511624/influences-of-dietary-reduced-nitrogen-n-and-phosphorus-p-on-chemical-body-composition-n-and-p-retention-and-health-traits-of-contemporary-barrows
#2
JOURNAL ARTICLE
Elisabeth Beckmüller, Jeannette Kluess, Liane Hüther, Susanne Kersten, Mareike Kölln, Christian Visscher, Sven Dänicke, Angelika Grümpel-Schlüter
Farmgate balances are used as a tool for monitoring nutrient surpluses at farm level. In Germany, preparation of farmgate balances is legally mandatory and also requires data on chemical body composition, especially concentration of nitrogen (N) and phosphorus (P), of farm animals. It is well known that increased N and P efficiency results in lowered N and P excretions with the manure and therefore mitigates negative consequences of high N and P release into the environment (e.g. eutrophication of surface waters), especially in areas with high livestock density...
March 21, 2024: Archives of Animal Nutrition
https://read.qxmd.com/read/38164041/furosemide-attenuates-tubulointerstitial-injury-and-allows-functional-testing-of-porcine-kidneys-during-normothermic-machine-perfusion
#3
JOURNAL ARTICLE
Baran Ogurlu, Tim L Hamelink, Veerle A Lantinga, Henri G D Leuvenink, Merel B F Pool, Cyril Moers
BACKGROUND: Normothermic machine perfusion (NMP) is a promising pretransplant kidney quality assessment platform, but it remains crucial to increase its diagnostic potential while ensuring minimal additional injury to the already damaged kidney. Interventions that alter tubular transport can influence renal function and injury during perfusion. This study aimed to determine whether furosemide and desmopressin affect renal function and injury during NMP. METHODS: Eighteen porcine kidneys (n = 6 per group) were subjected to 30 min of warm ischemia and 4 h of oxygenated hypothermic perfusion before being subjected to 6 h of NMP...
January 1, 2024: Artificial Organs
https://read.qxmd.com/read/38136813/serum-and-urinary-matrix-metalloproteinase-9-concentrations-in-dehydrated-horses
#4
JOURNAL ARTICLE
Julia N van Spijk, Hsiao-Chien Lo, Roswitha Merle, Ina-Gabriele Richter, Anne Diemar, Sabita D Stoeckle, Heidrun Gehlen
Matrix metalloproteinase-9 is increased in renal tissue in human kidney disease, but its role as a biomarker for kidney disease has not been fully evaluated yet. The aim of this study was to evaluate serum MMP-9 (sMMP-9) and urinary MMP-9 (uMMP-9) concentrations in dehydrated horses. Dehydrated horses were prospectively included. Blood and urinary samples were taken at admission, and after 12, 24, and 48 h (t0, t12, t24, t48), an anti-equine MMP-9 sandwich ELISA was used. Four healthy horses served as the controls...
December 7, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38129773/recurrent-exercise-induced-acute-kidney-injury-associated-with-hypouricemia-a-case-report-and-literature-review
#5
REVIEW
Jie Zhou, Min Zhang, Qionghong Xie, Ningxin Xu, Mingxin Li, Ming Zhang, Chuanming Hao
BACKGROUND: Hereditary renal hypouricemia (RHUC) is a heterogenous disorder characterized by defective uric acid (UA) reabsorption resulting in hypouricemia and increased fractional excretion of UA. RHUC is an important cause of exercise-induced acute kidney injury (EIAKI), nephrolithiasis and posterior reversible encephalopathy syndrome (PRES). We present here an unusual case of a patient with RHUC who presented with recurrent EIAKI and had two heterozygous mutations in the SLC2A9 gene...
December 21, 2023: BMC Nephrology
https://read.qxmd.com/read/37724354/measurement-of-plasma-protein-and-whole-body-protein-metabolism-using-15-n-glycine-in-a-young-adult-man-a-pilot-study
#6
JOURNAL ARTICLE
Peter Junghans, Gerhard Zuz, Hans Faust
A novel simplified method is presented for the estimation of the metabolism of plasma proteins (albumin, fibrinogen, α , β and γ -globulin, glycoprotein) with regard to the whole body protein metabolism in a young male volunteer (22 years, 81 kg body mass). This method is based on multiple oral administration of [15 N]glycine followed by measurement of 15 N in plasma proteins, total free amino acids, urea and excreted urinary N. The fractional synthesis rate of albumin was estimated to 6...
September 19, 2023: Isotopes in Environmental and Health Studies
https://read.qxmd.com/read/37562644/whey-protein-peptides-pew-and-llw-synergistically-ameliorate-hyperuricemia-and-modulate-gut-microbiota-in-potassium-oxonate-and-hypoxanthine-induced-hyperuricemic-rats
#7
JOURNAL ARTICLE
Xiaofen Qi, Kaifang Guan, Chunhong Liu, Haoran Chen, Ying Ma, Rongchun Wang
PEW and LLW are peptides derived from whey protein digestive products; both peptides exhibit xanthine oxidase inhibitory activity in vitro. However, it remains unclear whether these peptides can alleviate hyperuricemia (HUA) in vivo. In this study, we investigated the roles of PEW and LLW, both individually and in combination, in alleviating HUA induced by potassium oxonate and hypoxanthine. Together, PEW and LLW exhibited synergistic effects in reducing the serum levels of uric acid (UA), creatinine, and blood urea nitrogen, as well as increasing the fractional excretion of UA...
August 8, 2023: Journal of Dairy Science
https://read.qxmd.com/read/37452960/evaluation-of-simple-diagnostic-parameters-in-acute-kidney-injury-in-hospitalized-patients-diagnostic-recommendations-for-non-nephrologists
#8
JOURNAL ARTICLE
Anna Buckenmayer, Nadja Siebler, Christian S Haas
Acute kidney injury (AKI) is very common in hospitalized patients, affecting patient's mortality and morbidity. Major causes are prerenal AKI and acute tubular necrosis (ATN). Even though a variety of parameters/indices exist, their reliability and practicability are controversial: in fact, there is a need for a simple diagnostic approach for AKI in in-patients with parameters easily obtained in any hospital. The objective of the study was: (1) to assess reliability of simple laboratory parameters/indices to differentiate pre-/intrarenal AKI; (2) to evaluate the most reliable and feasible parameters/indices; and (3) to identify the possible impact of confounding factors...
September 2023: Internal and Emergency Medicine
https://read.qxmd.com/read/37384889/fractional-excretion-of-sodium-and-urea-are-useful-tools-in-the-evaluation-of-aki-commentary
#9
JOURNAL ARTICLE
Robert S Brown
No abstract text is available yet for this article.
June 1, 2023: Kidney360
https://read.qxmd.com/read/37384888/fractional-excretion-of-sodium-and-urea-are-useful-tools-in-the-evaluation-of-aki-con
#10
JOURNAL ARTICLE
Abraham W Aron, Jonathan G Amatruda
No abstract text is available yet for this article.
June 1, 2023: Kidney360
https://read.qxmd.com/read/37384887/fractional-excretion-of-sodium-and-urea-are-useful-tools-in-the-evaluation-of-aki-pro
#11
JOURNAL ARTICLE
Abdurrahman Hamadah, Kamel Gharaibeh
No abstract text is available yet for this article.
June 1, 2023: Kidney360
https://read.qxmd.com/read/37316471/biological-variation-of-biochemical-urine-and-serum-analytes-in-healthy-dogs
#12
JOURNAL ARTICLE
Anna K Selin, Inger Lilliehöök, Johannes Forkman, Anders Larsson, Lena Pelander, Emma M Strage
BACKGROUND: Biological variation (BV) of urinary (U) biochemical analytes has not been described in absolute terms, let alone as a ratio of the U-creatinine or fractional excretion in healthy dogs. These analytes are potential diagnostic tools for different types of kidney damage and electrolyte disorders in dogs. OBJECTIVES: We aimed to investigate the BV of specific gravity, osmolality, creatinine, urea, protein, glucose, chloride, sodium, potassium, calcium, and phosphate in urine from healthy pet dogs...
September 2023: Veterinary Clinical Pathology
https://read.qxmd.com/read/37108668/renal-disturbances-during-and-after-radioligand-therapy-of-neuroendocrine-tumors-extended-analysis-of-potential-acute-and-chronic-complications
#13
JOURNAL ARTICLE
Marek Saracyn, Adam Daniel Durma, Barbara Bober, Arkadiusz Lubas, Maciej Kołodziej, Waldemar Kapusta, Beata Dmochowska, Grzegorz Kamiński
Neuroendocrine tumors (NEN) are a group of neoplasms that arise from hormonal and neural cells. Despite a common origin, their clinical symptoms and outcomes are varied. They are most commonly localized in the gastrointestinal tract. Targeted radioligand therapy (RLT) is a treatment option which has proven to be successful in recent studies. However, the possible outcomes and true safety profile of the treatment need to be fully determined, especially by new, more sensitive methods. Our study aimed to present an extended analysis of acute and chronic renal complications during and after radioligand therapy using, for the first time in the literature, innovative and complex renal parameters...
April 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37033701/a-step-by-step-guide-for-the-diagnosis-and-management-of-hyponatraemia-in-patients-with-stroke
#14
REVIEW
Fotios Barkas, Georgia Anastasiou, George Liamis, Haralampos Milionis
Hyponatraemia is common in patients with stroke and associated with adverse outcomes and increased mortality risk. The present review presents the underlying causes and provides a thorough algorithm for the diagnosis and management of hyponatraemia in stroke patients. Concomitant diseases and therapies, such as diabetes, chronic kidney disease and heart failure, along with diuretics, antidepressants and proton pump inhibitors are the most common causes of hyponatraemia in community. In the setting of acute stroke, the emergence of hyponatraemia might be attributed to the administration of hypotonic solutions and drugs (ie...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/36823779/utility-of-fractional-excretion-of-urea-nitrogen-in-heart-failure-patients-with-chronic-kidney-disease
#15
JOURNAL ARTICLE
Yukihiro Watanabe, Yoshiaki Kubota, Takuya Nishino, Shuhei Tara, Katsuhito Kato, Daisuke Hayashi, Kosuke Mozawa, Junya Matsuda, Yukichi Tokita, Masahiro Yasutake, Kuniya Asai, Yu-Ki Iwasaki
AIMS: Maintenance of euvolaemia with diuretics is critical in heart failure (HF) patients with chronic kidney disease (CKD); however, it is challenging because no reliable marker of volume status exists. Fractional excretion of urea nitrogen (FEUN) is a useful index of volume status in patients with renal failure. We aimed to examine whether FEUN is a surrogate marker of volume status for risk stratification in HF patients with CKD. METHODS AND RESULTS: We examined 516 HF patients with CKD (defined as discharge estimated glomerular filtration rate < 60 mL/min/1...
June 2023: ESC Heart Failure
https://read.qxmd.com/read/36583434/bedside-prognostication-in-decompensated-heart-failure-no-easy-button
#16
EDITORIAL
Madhumathi Rao
No abstract text is available yet for this article.
December 30, 2022: Journal of the American Heart Association
https://read.qxmd.com/read/36583422/new-classification-for-the-combined-assessment-of-the-fractional-excretion-of-urea-nitrogen-and-estimated-plasma-volume-status-in-acute-heart-failure
#17
JOURNAL ARTICLE
Kazutaka Nogi, Tomoya Ueda, Takuya Nakamura, Maki Nogi, Satomi Ishihara, Yasuki Nakada, Yukihiro Hashimoto, Hitoshi Nakagawa, Taku Nishida, Ayako Seno, Kenji Onoue, Makoto Watanabe, Yoshihiko Saito
Background The fractional excretion of urea nitrogen (FEUN) has been used as a renal blood flow index related to cardiac output, and the estimated plasma volume status (ePVS) as a body fluid volume index. However, the usefulness of their combination in acute decompensated heart failure (HF) management is unclear. We investigated the effect of 4 hemodynamic categories according to the high and low FEUN and ePVS values at discharge on the long-term prognosis of patients with acute decompensated HF. Methods and Results Between April 2011 and December 2018, we retrospectively identified 466 patients with acute decompensated HF with FEUN and ePVS values at discharge...
December 30, 2022: Journal of the American Heart Association
https://read.qxmd.com/read/36477240/kidney-functions-adaptations-of-professional-soccer-players-in-response-to-an-entire-game-season
#18
JOURNAL ARTICLE
Rodrigo A S Peres, Irnak Marcelo Barbosa, Igor R Arouca, Karen V Paiva, Tainá B Coutinho, Victor C Tadeu, Anderson P Morales, Beatriz G Ribeiro, Natália Martins Feitosa, Cintia M DE Barros, Rodrigo N DA Fonseca, Jackson DE Souza-Menezes
This study investigated the renal function of soccer players after an entire game-season. Thirty-five athletes recruited to play for the Macae Futebol Clube were invited for this study, of which 18 athletes completed the entire game season. Blood and 24-hour urine were collected at the beginning (Pre-Season) and the end of the game season (Post-Season). Kidney functions were assessed by calculating the urinary excretion, clearance, and fractional excretion of the selected solutes. Plasma creatinine, sodium, total protein, and osmolality were lower in the Post-Season ...
2022: Anais da Academia Brasileira de Ciências
https://read.qxmd.com/read/36125096/hypouricemic-effect-of-gallic-acid-a-bioactive-compound-from-sonneratia-apetala-leaves-and-branches-on-hyperuricemic-mice
#19
JOURNAL ARTICLE
Linyun Jiang, Yulin Wu, Chang Qu, Yinsi Lin, Xiaoqing Yi, Changjun Gao, Jian Cai, Ziren Su, Huifang Zeng
As a tropical medicinal plant, Sonneratia apetala is mainly distributed in the southeast coastal areas of China. Recently, the hypouricemic effect of Sonneratia apetala leaves and branches (SAL) has been reported, but the active compound and its mechanism are unclear. Thus, this study aims to explore the effective fraction of SAL and the mechanism of its active compound on uric acid formation and excretion. SAL was extracted with ethyl acetate and concentrated to obtain solvent-free extracts (SAL-EA). The remains fraction (SAL-E) and the supernatant fraction (SAL-S) of SAL resulting from water extraction and alcohol precipitation were collected and dried...
September 20, 2022: Food & Function
https://read.qxmd.com/read/36065144/leucine-rich-alpha-2-glycoprotein-lrg-1-as-a-potential-kidney-injury-marker-in-kidney-transplant-recipients
#20
JOURNAL ARTICLE
Anna Popova, Aiga Vasiļvolfa, Kārlis Rācenis, Renārs Erts, Baiba Šlisere, Anna Jana Saulīte, Ieva Ziedina, Inese Folkmane, Harijs Čerņevskis, Juta Kroiča, Aivars Pētersons, Viktorija Kuzema
BACKGROUND Kidney transplantation is the treatment of choice for most patients with end-stage renal disease. To improve patient and transplant survival, non-invasive diagnostic methods for different pathologies are important. Leucine-rich alpha-2-glycoprotein (LRG-1) is an innovative biomarker that is elevated in cases of angiogenesis, inflammation, and kidney injury. However, there are limited data about the diagnostic role of LRG-1 in kidney transplant recipients. The aim of this study was to evaluate the association between serum LRG-1, urine LRG-1, and kidney transplant function and injury...
September 6, 2022: Annals of Transplantation: Quarterly of the Polish Transplantation Society
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