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https://www.readbyqxmd.com/read/29779285/-advances-in-the-molecular-mechanisms-of-perineural-invasion-in-salivary-adenoid-cystic-carcinoma
#1
Mei Zhang, Xin-Hua Liang, Ya-Ling Tang
Salivary adenoid cystic carcinoma is a very common malignant neoplasm in the salivary glands. One of the most important features of salivary cystic carcinoma is perineural invasion, which renders its complete removal is very difficult through clinical surgery. Consequently, tumor recurrence occurs easily after clinical surgery. Therefore, the molecular mechanisms of perineural invasion in salivary adenoid cystic carcinoma are necessary to explore. These mechanisms are reviewed in this paper.
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29779115/the-first-recombinant-viper-three-finger-toxins-inhibition-of-muscle-and-neuronal-nicotinic-acetylcholine-receptors
#2
Ya V Makarova, E V Kryukova, I V Shelukhina, D S Lebedev, T V Andreeva, D Yu Ryazantsev, S V Balandin, T V Ovchinnikova, V I Tsetlin, Yu N Utkin
Genes encoding two three-finger toxins TFT-AF and TFT-VN, nucleotide sequences of which were earlier determined by cloning cDNA from venom glands of vipers Azemiops feae and Vipera nikolskii, respectively, were expressed for the first time in E. coli cells. The biological activity of these toxins was studied by electrophysiological techniques, calcium imaging, and radioligand analysis. It was shown for the first time that viper three-finger toxins are antagonists of nicotinic acetylcholine receptors of neuronal and muscle type...
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29779047/over-diagnosis-of-potential-malignant-behavior-in-men-2a-associated-pheochromocytomas-using-the-pass-and-gapp-algorithms
#3
Adam Stenman, Jan Zedenius, Carl Christofer Juhlin
PURPOSE: Pheochromocytomas (PCCs) exhibit malignant potential, but current histological modalities for the proper detection of aggressive behavior are debated. The two most widespread algorithms are the "Pheochromocytoma of the Adrenal Gland Scaled Score" (PASS) and the "Grading System for Adrenal Pheochromocytoma and Paraganglioma" (GAPP), both which mostly rely on histological parameters to identify PCC patients at risk of disseminated disease. Since the algorithms are derived from studies using predominantly sporadic PCCs, little is known whether the PASS or GAPP scores can predict malignant potential in hereditary cases...
May 19, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29779010/low-mir200b-5p-levels-in-minor-salivary-glands-a-novel-molecular-marker-predicting-lymphoma-development-in-patients-with-sj%C3%A3-gren-s-syndrome
#4
Efstathia K Kapsogeorgou, Aristea Papageorgiou, Athanase D Protogerou, Michael Voulgarelis, Athanasios G Tzioufas
OBJECTIVES: Development of non-Hodgkin's lymphoma (NHL) is the major adverse outcome of Sjögren's syndrome (SS) affecting both morbidity and mortality. Preliminary evidence suggested that, although not deregulated compared with sicca controls, miR200b-5p levels are decreased in the minor salivary glands (MSGs) of SS patients with NHL. The aim of the current study was to evaluate the MSG expression of miR200b-5p in SS-associated NHLs and its potential predictive value for the identification of patients with SS susceptible to develop NHL...
May 19, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29778636/surgeon-performed-ultrasound-for-the-assessment-of-parotid-masses
#5
Melissa Zheng, Karolina A Plonowska, Madeleine P Strohl, William R Ryan
BACKGROUND: Studies on parotid gland ultrasound assessments performed specifically by surgeons are seldom reported. METHODS: Retrospective series of a single academic surgeon experience, analyzing 70 new parotid masses with evaluable preoperative SP-US characteristics, location measurements, and perioperative events. RESULTS: 31/70 masses were malignant. SP-US characteristics significantly associated with both malignancy and positive margins included extraparenchymal extension, irregular borders, hypervascularity, infiltration, and the lack of deep enhancement...
April 16, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29778483/effect-of-replacing-maize-silage-with-red-clover-silage-in-the-diet-on-milk-fatty-acid-composition-in-cows
#6
Franziska Schulz, Edwin Westreicher-Kristen, Joachim Molkentin, Karin Knappstein, Andreas Susenbeth
This study aimed to evaluate the effect of replacing maize silage plus soybean meal with red clover silage (RCS) plus wheat on the fatty acid (FA) profile in the milk fat of cows. Forty-four lactating German Holstein cows were used in a 4 × 4 Latin square design with 21-d periods composed of 13 d of adaptation to diets followed by an 8-d sampling phase. Experimental diets offered as total mixed ration consisted of a constant forage-to-concentrate ratio (75:25) with target proportions of RCS to maize silage of 15:60 (RCS15 ), 30:45 (RCS30 ), 45:30 (RCS45 ), and 60:15 (RCS60 ) on a dry matter basis...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29778482/randomized-noninferiority-field-trial-evaluating-cephapirin-sodium-for-treatment-of-nonsevere-clinical-mastitis
#7
T Tomazi, T A F Lopes, V Masson, J M Swinkels, M V Santos
The general objective of this study was to evaluate whether cephapirin sodium is noninferior compared with a positive control broad-spectrum product formulated with a combination of antimicrobials for intramammary treatment of nonsevere clinical mastitis. In addition, we compared the efficacy of treatments on the cure risks of pathogen groups (gram-positive, gram-negative, and cultures with no growth) based on culture results. A total of 346 cows distributed in 31 commercial dairy herds were selected to participate in the study, although only 236 met the criteria for evaluation of microbiological cure...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29778321/submandibular-gland-sparing-when-irradiating-neck-level-ib-in-the-treatment-of-oral-squamous-cell-carcinoma
#8
William C Jackson, Peter G Hawkins, George S Arnould, John Yao, Charles Mayo, Michelle Mierzwa
Patients with oral squamous cell carcinoma (OSqCCA) frequently require postoperative radiation (PORT), which may include contralateral level IB within the clinical target volume (CTV). The submandibular gland (SMG) is typically included within the level IB CTV; however, the SMG does not contain lymph nodes or lymphatic vessels. We hypothesized that level IB could be adequately irradiated while sparing the SMG to reduce xerostomia. Twelve patients with OSqCCA receiving PORT, which included the contralateral level IB within the planning target volume (PTV), were retrospectively reviewed and replanned using volumetric modulated arc therapy...
May 16, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29778320/simultaneously-avoiding-the-hippocampus-and-hypothalamic-pituitary-axis-during-whole-brain-radiotherapy-a-planning-study
#9
Xing-Wen Fan, Juan-Qi Wang, Jun-Lan Wu, Hong-Bing Wang, Kai-Liang Wu
Whole brain radiotherapy (WBRT) is the preferred treatment for multiple brain metastases, and patients with limited-stage small cell lung cancer undergo prophylactic cranial irradiation after complete remission. However, neurotoxicity remains a complication. In addition to protecting the hippocampus from irradiation to preserve cognitive function, it is also critical to avoid irradiating the hypothalamic-pituitary axis to preserve endocrine and immune function. This study aimed to evaluate the feasibility of delivering WBRT while protecting the hippocampus and hypothalamic-pituitary axis...
May 16, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29778280/influence-of-cataract-surgery-on-meibomian-gland-dysfunction
#10
A El Ameen, S Majzoub, G Vandermeer, P-J Pisella
PURPOSE: To evaluate the influence of cataract surgery on Meibomian gland dysfunction, in particular on postoperative functional symptoms. PATIENTS AND METHODS: Thirty patients who underwent cataract surgery were included in the study. A clinical examination (OSDI questionnaire, measurement of tear break-up time (TBUT), corneal staining, Meibomian gland expression test) and a paraclinical evaluation (Meibomian gland loss [MGL] measured using ImageJ on Meibography, conjunctival hyperemia and non-invasive keratograph break-up time [NIK-BUT]) were performed preoperatively and at 1month and 3months after phacoemulsification...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29777899/congenital-dyshormonogenic-hypothyroidism-with-goiter-caused-by-a-sodium-iodide-symporter-slc5a5-mutation-in-a-family-of-shih-tzu-dogs
#11
E A Soler Arias, V A Castillo, J D Garcia, J C Fyfe
An iodide transport defect (ITD) in the thyroid gland was determined to cause congenital dyshormonogenic hypothyroidism with goiter (CDHG) in 2 members of a family of Shih-Tzu dogs. Strikingly, both dogs were also diagnosed with dilated cardiomyopathy at 24 and 1.5 mo of age. The only sign of hypothyroidism was a moderate growth delay in the adult dog. The ITD was recognized by the absence of uptake of technetium-99m in the salivary glands (sg) and goiter observed by scintigraphy. In the same scan, radiopharmaceutical uptake was found in the anterior mediastinum of both dogs and in the right axillary lymph node in the oldest dog...
April 24, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29777417/effects-of-dietary-microencapsulated-cymbopogon-flexuosus-essential-oil-on-reproductive-related-parameters-in-male-rhamdia-quelen
#12
Carine de Freitas Souza, Cristine Rampelotto, Bruno Bianchi Loureiro, Fernanda Alves Pereira, Adriane Erbice Bianchini, Carine Dahl Corcini, Antonio Sergio Varela Junior, Tatiana Emanuelli, Leila Picolli da Silva, Sílvio Teixeira da Costa, Kalyne Bertolin, Monique Tomazele Rovani, Paulo Bayard Dias Gonçalves, Berta Maria Heinzmann, Bernardo Baldisserotto
In aquaculture, nutrition and supplemented diets have been shown to affect broodstock reproductive performance. In this study, we investigated the effects of dietary supplementation with Cymbopogon flexuosus essential oil (CFEO) microcapsules on reproductive-related parameters in silver catfish (Rhamdia quelen) male broodfish. Adult male broodstocks were separated into three groups according to the concentrations of supplemented CFEO (0.0 = control; 1.0 or 3.0 mL per kg of diet). After 20 days under experimental conditions, the animals were euthanized and the gonads were harvested for gonadosomatic index, sperm analysis, oxidative stress, and histopathology; testosterone levels were measured in the plasma; gene expression of prl, smtl, pomca, and pomcb was assessed in the pituitary gland by real-time PCR...
May 18, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29776997/turning-workers-into-false-queens-the-role-of-exogenous-pheromones-in-regulating-reproduction-in-worker-honey-bees
#13
Abdullahi A Yusuf, Robin M Crewe, Christian W W Pirk
One of the responses that honey bee workers can make in the event of queen loss is to develop into false queens. False queens are workers that exhibit both behavioural and physiological traits similar to those of a true queen. However, the presence of more than one false queen in a colony distorts the established hierarchies. As transformation into a false queen occurs after emergence as an adult, we tested the effect of worker mobile pheromone carriers (PCs) treated with exogenously supplied pheromones on their nestmates...
May 18, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29776996/effects-of-chronic-exposure-to-12%C3%A2-saltwater-on-the-endocrine-physiology-of-juvenile-american-alligator-alligator-mississippiensis
#14
P C Faulkner, M L Burleson, L Simonitis, C Marshall, D Hala, L H Petersen
American alligator ( Alligator mississippiensis , Linnaeus) habitats are prone to saltwater intrusion following major storms, hurricanes or droughts. Anthropogenic impacts affecting hydrology of freshwater systems may exacerbate saltwater intrusion into freshwater habitats. The endocrine system of alligators is susceptible to changes in the environment but it is currently not known how the crocodilian physiological system responds to environmental stressors such as salinity. Juvenile alligators were exposed to 12‰ saltwater for 5 weeks to determine effects of chronic exposure to saline environments...
May 18, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29776947/rectal-mucocele-in-the-anterior-wall-of-the-rectum
#15
Daisuke Ishii, Takanori Aoki, Satoshi Inaba, Hidehiko Yabuki
An 84-year-old man presented in 2009 with a sensation of discomfort in his anus, combined with difficulty in urination. He had previously undergone a haemorrhoidectomy in 1964. After examination, he was diagnosed with a rectal mucosal cyst and followed up for observation. In 2015, he presented to our hospital complaining that the cyst was prolapsing from his anus. CT revealed a 48×41 mm cystic mass in the anterior wall of the rectum. Tumour extirpation, via a transanal route, was performed. The postoperative pathological diagnosis confirmed a rectal mucocele...
May 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29776537/comparative-study-on-metabolite-level-in-tissue-specific-human-mesenchymal-stem-cells-by-an-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#16
Seul Ji Lee, TacGhee Yi, Soo Hyun Ahn, Dong Kyu Lim, Si-Na Kim, Hyun-Joo Lee, Yun-Kyoung Cho, Jae-Yol Lim, Jong-Hyuk Sung, Jeong-Ho Yun, Johan Lim, Sun U Song, Sung Won Kwon
Mesenchymal stem cells (MSCs) are a promising therapeutic option for cell-based therapy due to their immunomodulatory and regenerative properties. They can be isolated from various adult tissues, including bone marrow, fat, dental tissue, and glandular tissue. Although they share common characteristics, little is known about the biological differences between MSC populations derived from different tissues. In this study, we used MS to compare the endogenous metabolite level in the human MSCs originating from the bone marrow, adipose tissue, periodontal ligaments, and salivary glands...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29775577/caspase-3-regulates-yap-dependent-cell-proliferation-and-organ-size
#17
Yahav Yosefzon, Despina Soteriou, Alona Feldman, Lana Kostic, Elle Koren, Samara Brown, Roi Ankawa, Egor Sedov, Fabian Glaser, Yaron Fuchs
Apoptosis culminates in the activation of caspase-3, which plays an important role in implementing the cell death program. Here, we reveal a non-apoptotic role of caspase-3 as a key regulator of cell proliferation and organ size. Caspase-3 is specifically activated in the proliferating cells of the sebaceous gland, but does not instruct cell elimination. Deletion or chemical inhibition of caspase-3 diminishes cell proliferation, decreases cell number and reduces sebaceous gland size in vivo. Exploring the underlying mechanism, we demonstrate that α-catenin is cleaved by caspase-3, thus facilitating the activation and nuclear translocation of yes-associated protein (YAP), a vital regulator of organ size...
May 17, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29775567/characterization-of-the-gonadotropin-releasing-hormone-system-in-the-neotropical-teleost-steindachneridion-parahybae-during-the-annual-reproductive-cycle-in-captivity
#18
Renato Massaaki Honji, Danilo Caneppele, Matias Pandolfi, Fabiana Laura Lo Nostro, Renata Guimarães Moreira
This study evaluated by immunohistochemical and western blot methods, the distribution of two distinct gonadotropin-releasing hormones (GnRHs), corresponding to catfish GnRH (cfGnRH or GnRH1) and chicken-II GnRH (cGnRH-II or GnRH2), in Steindachneridion parahybae females in captivity, focusing these analyses on the reproductive cycle by semi-quantification of optical density (OD). Further, we found that the GnRH neuronal systems co-localized with their respective GnRH-associated peptides (GAPs). A group of neurons immunoreactive (ir) to GnRH1 were identified along the ventral region of the olfactory bulb (vOB) in the telencephalon (vTel) and in the main areas of the diencephalon (especially the medial basal hypothalamus, HBM), including fibers extending into the pituitary gland...
May 15, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29775456/maternal-obesogenic-diet-induces-endometrial-hyperplasia-an-early-hallmark-of-endometrial-cancer-in-a-diethylstilbestrol-mouse-model
#19
Theresa O Owuor, Michaela Reid, Lauren Reschke, Ian Hagemann, Suellen Greco, Zeel Modi, Kelle H Moley
Thirty-eight percent of US adult women are obese, meaning that more children are now born of overweight and obese mothers, leading to an increase in predisposition to several adult onset diseases. To explore this phenomenon, we developed a maternal obesity animal model by feeding mice a diet composed of high fat/ high sugar (HF/HS) and assessed both maternal diet and offspring diet on the development of endometrial cancer (ECa). We show that maternal diet by itself did not lead to ECa initiation in wildtype offspring of the C57Bl/6J mouse strain...
2018: PloS One
https://www.readbyqxmd.com/read/29775122/nitration-of-mnsod-in-the-carotid-body-and-adrenal-gland-induced-by-chronic-intermittent-hypoxia
#20
Esteban A Moya, Paulina Arias, Rodrigo Iturriaga
Chronic intermittent hypoxia (CIH), main feature of obstructive sleep apnea, produces nitro-oxidative stress, which contributes to potentiate carotid body (CB) chemosensory discharges and sympathetic-adrenal-axis activity, leading to hypertension. The MnSOD enzymatic activity, a key enzyme on oxidative stress control, is reduced by superoxide-induced nitration. However, the effects of CIH-induced nitration on MnSOD enzymatic activity in the CB and adrenal gland are not known. We studied the effects of CIH on MnSOD protein and immunoreactive (MnSOD-ir) levels in the CB, adrenal gland and superior cervical ganglion (SCG), and on 3-nitrotyrosine (3-NT-ir), CuZnSOD (CuZnSOD-ir), MnSOD nitration, and its enzymatic activity in the CB and adrenal gland from male Sprague-Dawley rats exposed to CIH for 7 days...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
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