keyword
https://read.qxmd.com/read/37611920/virus-based-pyroelectricity
#21
JOURNAL ARTICLE
Han Kim, Kento Okada, Inseok Chae, Butaek Lim, Seungwook Ji, Yoonji Kwon, Seung-Wuk Lee
We present the first observation of heat-induced electrical potential generation on a virus and its detection through pyroelectricity. Specifically, we investigate the pyroelectric properties of the M13 phage, which possesses inherent dipole structures derived from the noncentrosymmetric arrangement of the major coat protein (pVIII) with an α-helical conformation. We achieve unidirectional polarization of the phage through genetic engineering of the tail protein (pIII) and template-assisted self-assembly techniques...
August 23, 2023: Advanced Materials
https://read.qxmd.com/read/37601908/biofabrication-of-novel-silver-and-zinc-oxide-nanoparticles-from-fusarium-solani-ior-825-and-their-potential-application-in-agriculture-as-biocontrol-agents-of-phytopathogens-and-seed-germination-and-seedling-growth-promoters
#22
JOURNAL ARTICLE
Joanna Trzcińska-Wencel, Magdalena Wypij, Artur P Terzyk, Mahendra Rai, Patrycja Golińska
Introduction: Plant pathogenic microorganisms adversely affect the growth and yield of crops, which consequently leads to losses in food production. Metal-based nanoparticles (MNPs) can be a remedy to solve this problem. Methods: Novel silver nanoparticles (AgNPs) and zinc oxide nanoparticles (ZnONPs) were biosynthesized from Fusarium solani IOR 825 and characterized using Dynamic Light Scattering (DLS), Fourier Transform Infrared (FTIR) spectroscopy, Transmission Electron Microscopy (TEM), X-ray diffraction (XRD) and measurement of Zeta potential...
2023: Frontiers in Chemistry
https://read.qxmd.com/read/37579187/docksurf-a-molecular-modeling-software-for-the-prediction-of-protein-surface-adhesion
#23
JOURNAL ARTICLE
Florent Barbault, Eric Brémond, Julien Rey, Pierre Tufféry, François Maurel
The elucidation of structural interfaces between proteins and inorganic surfaces is a crucial aspect of bionanotechnology development. Despite its significance, the interfacial structures between proteins and metallic surfaces are yet to be fully understood, and the lack of experimental investigation has impeded the development of many devices. To overcome this limitation, we suggest considering the generation of protein/surface structures as a molecular docking problem with a homogenous plan as the target...
August 14, 2023: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/37500780/development-of-epistatic-yes-and-and-protein-logic-gates-and-their-assembly-into-signalling-cascades
#24
JOURNAL ARTICLE
Zhong Guo, Oleh Smutok, Cagla Ergun Ayva, Patricia Walden, Jake Parker, Jason Whitfield, Claudia E Vickers, Jacobus P J Ungerer, Evgeny Katz, Kirill Alexandrov
The construction and assembly of artificial allosteric protein switches into information and energy processing networks connected to both biological and non-biological systems is a central goal of synthetic biology and bionanotechnology. However, designing protein switches with the desired input, output and performance parameters is challenging. Here we use a range of reporter proteins to demonstrate that their chimeras with duplicated receptor domains produce YES gate protein switches with large (up to 9,000-fold) dynamic ranges and fast (minutes) response rates...
July 27, 2023: Nature Nanotechnology
https://read.qxmd.com/read/37449032/sequence-rules-for-gold-binding-peptides
#25
JOURNAL ARTICLE
Jose Isagani B Janairo
Metal-binding peptides play a central role in bionanotechnology, wherein they are responsible for directing growth and influencing the resulting properties of inorganic nanomaterials. One of the key advantages of using peptides to create nanomaterials is their versatility, wherein subtle changes in the sequence can have a dramatic effect on the structure and properties of the nanomaterial. However, precisely knowing which position and which amino acid should be modified within a given sequence to enhance a specific property can be a daunting challenge owing to combinatorial complexity...
July 12, 2023: RSC Advances
https://read.qxmd.com/read/37427368/how-nanotherapeutic-platforms-play-a-key-role-in-glioma-a-comprehensive-review-of-literature
#26
REVIEW
Yongqing Yang, Nianlan Cheng, Qiao Luo, Ni Shao, Xiaocong Ma, Jifeng Chen, Liangping Luo, Zeyu Xiao
Glioblastoma (GBM), a highly aggressive form of brain cancer, is considered one of the deadliest cancers, and even with the most advanced medical treatments, most affected patients have a poor prognosis. However, recent advances in nanotechnology offer promising avenues for the development of versatile therapeutic and diagnostic nanoplatforms that can deliver drugs to brain tumor sites through the blood-brain barrier (BBB). Despite these breakthroughs, the use of nanoplatforms in GBM therapy has been a subject of great controversy due to concerns over the biosafety of these nanoplatforms...
2023: International Journal of Nanomedicine
https://read.qxmd.com/read/37421430/nanocargos-designed-with-synthetic-and-natural-polymers-for-ovarian-cancer-management
#27
REVIEW
Sharon Sofini Ps, Arina Guha, Balasubramanian Deepika, Saranya Udayakumar, Moupriya Nag, Dibyajit Lahiri, Agnishwar Girigoswami, Koyeli Girigoswami
Ovarian cancer cells usually spread in the peritoneal region, and if chemotherapeutic drugs can be given in these regions with proximity, then the anticancer property of the chemotherapeutic drugs can enhance. However, chemotherapeutic drug administrations are hindered by local toxicity. In the drug delivery system, microparticles or nanoparticles are administered in a controlled manner. Microparticles stay in a close vicinity while nanoparticles are smaller and can move evenly in the peritoneum. Intravenous administration of the drug evenly distributes the medicine in the target places and if the composition of the drug has nanoparticles it will have more specificity and will have easy access to the cancer cells and tumors...
July 8, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37375226/molecular-engineering-of-e-coli-bacterioferritin-a-versatile-nanodimensional-protein-cage
#28
JOURNAL ARTICLE
Anton M van der Ven, Hawa Gyamfi, Uthaiwan Suttisansanee, Muhammad S Ahmad, Zhengding Su, Robert M Taylor, Amanda Poole, Sorina Chiorean, Elisabeth Daub, Taylor Urquhart, John F Honek
Currently, intense interest is focused on the discovery and application of new multisubunit cage proteins and spherical virus capsids to the fields of bionanotechnology, drug delivery, and diagnostic imaging as their internal cavities can serve as hosts for fluorophores or bioactive molecular cargo. Bacterioferritin is unusual in the ferritin protein superfamily of iron-storage cage proteins in that it contains twelve heme cofactors and is homomeric. The goal of the present study is to expand the capabilities of ferritins by developing new approaches to molecular cargo encapsulation employing bacterioferritin...
June 9, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37368306/from-synthesis-to-clinical-trial-novel-bioinductive-calcium-deficient-ha-%C3%AE-tcp-bone-grafting-nanomaterial
#29
JOURNAL ARTICLE
Oleg Mishchenko, Anna Yanovska, Oksana Sulaieva, Roman Moskalenko, Mykola Pernakov, Yevheniia Husak, Viktoriia Korniienko, Volodymyr Deineka, Oleksii Kosinov, Olga Varakuta, Simonas Ramanavicius, Suren Varzhapetjan, Almira Ramanaviciene, Dzanna Krumina, Gundega Knipše, Arunas Ramanavicius, Maksym Pogorielov
Maxillary sinus augmentation is a commonly used procedure for the placement of dental implants. However, the use of natural and synthetic materials in this procedure has resulted in postoperative complications ranging from 12% to 38%. To address this issue, we developed a novel calcium deficient HA/β-TCP bone grafting nanomaterial using a two-step synthesis method with appropriate structural and chemical parameters for sinus lifting applications. We demonstrated that our nanomaterial exhibits high biocompatibility, enhances cell proliferation, and stimulates collagen expression...
June 17, 2023: Nanomaterials
https://read.qxmd.com/read/37250164/cell-derived-nanovesicles-from-mesenchymal-stem-cells-as-extracellular-vesicle-mimetics-in-wound-healing
#30
JOURNAL ARTICLE
Yub Raj Neupane, Harish K Handral, Syed Abdullah Alkaff, Wei Heng Chng, Gopalakrishnan Venkatesan, Chenyuan Huang, Choon Keong Lee, Jiong-Wei Wang, Gopu Sriram, Rhonnie Austria Dienzo, Wen Feng Lu, Yusuf Ali, Bertrand Czarny, Giorgia Pastorin
Wound healing is a dynamic process that involves a series of molecular and cellular events aimed at replacing devitalized and missing cellular components and/or tissue layers. Recently, extracellular vesicles (EVs), naturally cell-secreted lipid membrane-bound vesicles laden with biological cargos including proteins, lipids, and nucleic acids, have drawn wide attention due to their ability to promote wound healing and tissue regeneration. However, current exploitation of EVs as therapeutic agents is limited by their low isolation yields and tedious isolation processes...
May 2023: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/37234111/photoactivated-artificial-molecular-motors
#31
REVIEW
Stefano Corra, Massimiliano Curcio, Alberto Credi
Accurate control of long-range motion at the molecular scale holds great potential for the development of ground-breaking applications in energy storage and bionanotechnology. The past decade has seen tremendous development in this area, with a focus on the directional operation away from thermal equilibrium, giving rise to tailored man-made molecular motors. As light is a highly tunable, controllable, clean, and renewable source of energy, photochemical processes are appealing to activate molecular motors...
May 22, 2023: JACS Au
https://read.qxmd.com/read/37180257/a-review-on-nanoparticles-characteristics-synthesis-applications-and-challenges
#32
REVIEW
Khadijah A Altammar
The significance of nanoparticles (NPs) in technological advancements is due to their adaptable characteristics and enhanced performance over their parent material. They are frequently synthesized by reducing metal ions into uncharged nanoparticles using hazardous reducing agents. However, there have been several initiatives in recent years to create green technology that uses natural resources instead of dangerous chemicals to produce nanoparticles. In green synthesis, biological methods are used for the synthesis of NPs because biological methods are eco-friendly, clean, safe, cost-effective, uncomplicated, and highly productive...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37120846/an-ultra-stable-self-assembled-antibacterial-nanospears-made-of-protein
#33
JOURNAL ARTICLE
Christian K O Dzuvor, Bhuvana K Shanbhag, Hsin-Hui Shen, Victoria S Haritos, Lizhong He
Protein-based nanomaterials have broad applications in the biomedical and bionanotechnological sectors owing to their outstanding properties such as high biocompatibility and biodegradability, structural stability, sophisticated functional versatility, and being environmentally benign. They have gained considerable attention in drug delivery, cancer therapeutics, vaccines, immunotherapies, biosensing and biocatalysis. However, so far, in the battle against the increasing reports of antibiotic resistance and emerging drug-resistant bacteria, unique nanostructures of this kind are lacking, hindering their potential next-generation antibacterial agents...
April 30, 2023: Advanced Materials
https://read.qxmd.com/read/37106512/applications-of-silver-nanoparticles-in-patent-research
#34
JOURNAL ARTICLE
Ana Paula G B Azevedo, Nathalia Müller, Celso Sant Anna
BACKGROUND: Silver nanoparticles (AgNPs) have been widely applied in research and industrial fields, finding applications in nanomedicine, drug delivery, biomedical devices, electronics, the energy sector, and environmental protection. Patents provide information on the industrial viability of product technologies, and the number of patent documents provides an estimate of the evolution of a specific technological field. AIMS: The present work aims to describe the current trends in AgNPs patent applications...
April 27, 2023: Recent Patents on Nanotechnology
https://read.qxmd.com/read/37103908/role-of-membrane-features-on-the-permeability-behavior-of-polymersomes-and-the-potential-impacts-on-drug-encapsulation-and-release
#35
JOURNAL ARTICLE
Fernando A de Oliveira, Carin Cristina da Silva Batista, Peter Černoch, Vladimir Sincari, Alessandro Jäger, Eliézer Jäger, Fernando C Giacomelli
Self-assembled bilayer structures such as those produced from amphiphilic block copolymers (polymersomes) are potentially useful in a wide array of applications including the production of artificial cells and organelles, nanoreactors, and delivery systems. These constructs are of important fundamental interest, and they are also frequently considered toward advances in bionanotechnology and nanomedicine. In this framework, membrane permeability is perhaps the most important property of such functional materials...
April 27, 2023: Biomacromolecules
https://read.qxmd.com/read/37101573/ferritin-a-promising-nanoreactor-and-nanocarrier-for-bionanotechnology
#36
REVIEW
Abhinav Mohanty, Akankshika Parida, Rohit Kumar Raut, Rabindra K Behera
The essence of bionanotechnology lies in the application of nanotechnology/nanomaterials to solve the biological problems. Quantum dots and nanoparticles hold potential biomedical applications, but their inherent problems such as low solubility and associated toxicity due to their interactions at nonspecific target sites is a major concern. The self-assembled, thermostable, ferritin protein nanocages possessing natural iron scavenging ability have emerged as a potential solution to all the above-mentioned problems by acting as nanoreactor and nanocarrier...
June 15, 2022: ACS Bio Med Chem Au
https://read.qxmd.com/read/37093216/stability-of-dna-origami-nanostructures-in-physiological-media-the-role-of-molecular-interactions
#37
REVIEW
Veikko Linko, Adrian Keller
Programmable, custom-shaped, and nanometer-precise DNA origami nanostructures have rapidly emerged as prospective and versatile tools in bionanotechnology and biomedicine. Despite tremendous progress in their utilization in these fields, essential questions related to their structural stability under physiological conditions remain unanswered. Here, DNA origami stability is explored by strictly focusing on distinct molecular-level interactions. In this regard, the fundamental stabilizing and destabilizing ionic interactions as well as interactions involving various enzymes and other proteins are discussed, and their role in maintaining, modulating, or decreasing the structural integrity and colloidal stability of DNA origami nanostructures is summarized...
April 24, 2023: Small
https://read.qxmd.com/read/37017562/achieving-higher-hierarchical-structures-by-cooperative-assembly-of-tripeptides-with-reverse-sequences
#38
JOURNAL ARTICLE
Zhongyan Wang, Yuna Shang, Hongjing Luo, Cuihong Yang, Zhimou Yang, Chunhua Ren, Jianfeng Liu
Hierarchical self-assembly based on peptides in nature is a multi-component interaction process, providing a broad platform for various bionanotechnological applications. However, the study of controlling the hierarchical structure transformation via the cooperation rules of different sequences is still rarely reported. Herein, we report a novel strategy of achieving higher hierarchical structures through cooperative self-assembly of hydrophobic tripeptides with reverse sequences. We unexpectedly found that Nap-FVY and its reverse sequence Nap-YVF self-assembled into nanospheres, respectively, while their mixture formed nanofibers, obviously exhibiting a low-to-high hierarchical structure transformation...
April 5, 2023: Nanoscale
https://read.qxmd.com/read/36881522/electrostatic-theory-of-the-acidity-of-the-solution-in-the-lumina-of-viruses-and-virus-like-particles
#39
JOURNAL ARTICLE
H J Muhren, Paul van der Schoot
Recently, Maassen et al. measured an appreciable pH difference between the bulk solution and the solution in the lumen of virus-like particles, self-assembled in an aqueous buffer solution containing the coat proteins of a simple plant virus and polyanions (Maassen, S. J.; et al. Small 2018 , 14 , 1802081). They attribute this to the Donnan effect, caused by an imbalance between the number of negative charges on the encapsulated polyelectrolyte molecules and the number of positive charges on the RNA binding domains of the coat proteins that make up the virus shell or capsid...
March 7, 2023: Journal of Physical Chemistry. B
https://read.qxmd.com/read/36836866/bionanotechnology-in-agriculture-a-one-health-approach
#40
REVIEW
Mayara Santana Dos Santos, Sérgio Antunes Filho, Bianca Pizzorno Backx
Healthy eating habits are one of the requirements for the health of society. In particular, in natura foods are increasingly encouraged, since they have a high concentration of nutrients. However, these foods are often grown in the presence of agrochemicals, such as fertilizers and pesticides. To increase crop productivity and achieve high vigor standards in less time, farmers make excessive use of agrochemicals that generate various economic, environmental, and clinical problems. In this way, bionanotechnology appears as an ally in developing technologies to improve planting conditions, ranging from the health of farmers and consumers to the production of new foods and functional foods...
February 12, 2023: Life
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