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https://www.readbyqxmd.com/read/27922833/x-ray-photoelectron-spectroscopy-and-transmission-electron-microscopy-analysis-of-silver-coated-gold-nanorods-designed-for-bionanotechnology-applications
#1
Fumiya Watanabe, Zeid A Nima, Takumi Honda, Masatoshi Mitsuhara, Minoru Nishida, Alexandru S Biris
Multicomponent nano-agents were designed and built via a core-shell approach to enhance their surface enhanced Raman scattering (SERS) signals. These nano-agents had 36 nm × 12 nm gold nanorod cores coated by 4 nm thick silver shell films and a subsequent thin bifunctional thiolated polyethylene glycol (HS-PEG-COOH) layer. Ambient time-lapsed SERS signal measurements of these functionalized nanorods taken over a two-week period indicated no signal degradation, suggesting that large portions of the silver shells remained in pure metallic form...
December 6, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27914059/evolution-inspired-computational-design-of-symmetric-proteins
#2
Arnout R D Voet, David Simoncini, Jeremy R H Tame, Kam Y J Zhang
Monomeric proteins with a number of identical repeats creating symmetrical structures are potentially very valuable building blocks with a variety of bionanotechnological applications. As such proteins do not occur naturally, the emerging field of computational protein design serves as an excellent tool to create them from nonsymmetrical templates. Existing pseudo-symmetrical proteins are believed to have evolved from oligomeric precursors by duplication and fusion of identical repeats. Here we describe a computational workflow to reverse-engineer this evolutionary process in order to create stable proteins consisting of identical sequence repeats...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27905946/chemically-and-thermally-stable-silica-nanowires-with-a-%C3%AE-sheet-peptide-core-for-bionanotechnology
#3
Zahraa S Al-Garawi, George E Kostakis, Louise C Serpell
BACKGROUND: A series of amyloidogenic peptides based on the sequence KFFEAAAKKFFE template the silica precursor, tetraethyl orthosilicate to form silica-nanowires containing a cross-β peptide core. RESULTS: Investigation of the stability of these fibres reveals that the silica layers protect the silica-nanowires allowing them to maintain their shape and physical and chemical properties after incubation with organic solvents such as 2-propanol, ethanol, and acetonitrile, as well as in a strong acidic solution at pH 1...
December 1, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27866626/seaweeds-a-resource-for-marine-bionanotechnology
#4
Sri Ramkumar Vijayan, Prakash Santhiyagu, Ramasubburayan Ramasamy, Pugazhendhi Arivalagan, Gopalakrishnan Kumar, Kannapiran Ethiraj, Babu Rajendran Ramaswamy
Marine bionanotechnology is one of the most promising areas of research in modern science and technology. Although there are multitude methods for the synthesis of nanoparticles (NPs), there is an increasing attention in developing high-yield, low-cost, non-toxic and eco-friendly procedures. The vital advantages of greener synthesis are cost-effective, reduced usage of toxic chemicals and abundant availability of resources. During the last ten years, there have been many biological entities used to elevate novel, greener and affordable methods for the metal NPs synthesis...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27783468/design-of-nanoscale-enzyme-complexes-based-on-various-scaffolding-materials-for-biomass-conversion-and-immobilization
#5
REVIEW
Jeong Eun Hyeon, Sang Kyu Shin, Sung Ok Han
The utilization of scaffolds for enzyme immobilization involves advanced bionanotechnology applications in biorefinery fields, which can be achieved by optimizing the function of various enzymes. This review presents various current scaffolding techniques based on proteins, microbes and nanomaterials for enzyme immobilization, as well as the impact of these techniques on the biorefinery of lignocellulosic materials. Among them, architectural scaffolds have applied to useful strategies for protein engineering to improve the performance of immobilized enzymes in several industrial and research fields...
November 2016: Biotechnology Journal
https://www.readbyqxmd.com/read/27700108/towards-single-electron-nanoelectronics-using-self-assembled-dna-structure
#6
Kosti Tuomas Olavi Tapio, Jenni Leppiniemi, Boxuan Shen, Vesa P Hytönen, Wolfgang Fritzsche, J Jussi Toppari
DNA based structures offer an adaptable and robust way to develop customized nanostructures for various purposes in bionanotechnology. One main aim in this field is to develop a DNA nano-breadboard for a controllable attachment of nanoparticles or biomolecules to form specific nanoelectronic devices. Here we conjugate three gold nanoparticles on a defined size TX-tile assembly into a linear pattern to form nanometer scale isolated islands that could be utilized in a room temperature single electron transistor...
October 4, 2016: Nano Letters
https://www.readbyqxmd.com/read/27569200/antimicrobial-graphene-family-materials-progress-advances-hopes-and-fears
#7
REVIEW
Anna Lukowiak, Anna Kedziora, Wieslaw Strek
Graphene-based materials have become very popular bionanotechnological instruments in the last few years. Since 2010, the graphene family materials have been recognized as worthy of attention due to its antimicrobial properties. Functionalization of graphene (or rather graphene oxide) surface creates the possibilities to obtain efficient antimicrobial agents. In this review, progress and advances in this field in the last few years are described and discussed. Special attention is devoted to materials based on graphene oxide in which specifically selected components significantly modify biological activity of this carbon structure...
October 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/27540604/durable-proteo-hybrid-vesicles-for-the-extended-functional-lifetime-of-membrane-proteins-in-bionanotechnology
#8
Sanobar Khan, Mengqiu Li, Stephen P Muench, Lars J C Jeuken, Paul A Beales
The full capabilities of membrane proteins in bionanotechnology can only be realised through improvements in their reconstitution environments that combine biocompatibility to support function and durability for long term stability. We demonstrate that hybrid vesicles composed of natural phospholipids and synthetic diblock copolymers have the potential to achieve these criteria.
September 21, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27524092/receptor-ligand-interactions-advanced-biomedical-applications
#9
REVIEW
Ivan Guryanov, Stefano Fiorucci, Tatiana Tennikova
Receptor-ligand interactions (RLIs) are at the base of all biological events occurring in living cells. The understanding of interactions between complementary macromolecules in biological systems represents a high-priority research area in bionanotechnology to design the artificial systems mimicking natural processes. This review summarizes and analyzes RLIs in some cutting-edge biomedical fields, in particular, for the preparation of novel stationary phases to separate complex biological mixtures in medical diagnostics, for the design of ultrasensitive biosensors for identification of biomarkers of various diseases at early stages, as well as in the development of innovative biomaterials and approaches for regenerative medicine...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27426103/protein-cages-and-synthetic-polymers-a-fruitful-symbiosis-for-drug-delivery-applications-bionanotechnology-and-materials-science
#10
Martin Rother, Martin G Nussbaumer, Kasper Renggli, Nico Bruns
Protein cages are hollow protein nanoparticles, such as viral capsids, virus-like particles, ferritin, heat-shock proteins and chaperonins. They have well-defined capsule-like structures with a monodisperse size. Their protein subunits can be modified by genetic engineering at predetermined positions, allowing for example site-selective introduction of attachment points for functional groups, catalysts or targeting ligands on their outer surface, in their interior and between subunits. Therefore, protein cages have been extensively explored as functional entities in bionanotechnology, as drug-delivery or gene-delivery vehicles, as nanoreactors or as templates for the synthesis of organic and inorganic nanomaterials...
July 18, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27340498/the-role-of-alkyl-substituents-in-deazaadenine-based-diarylethene-photoswitches
#11
Christopher Sarter, Michael Heimes, Andres Jäschke
Diarylethenes are an important class of reversible photoswitches and often claimed to require two alkyl substituents at the carbon atoms between which the bond is formed or broken in the electrocyclic rearrangement. Here we probe this claim by the synthesis and characterization of four pairs of deazaadenine-based diarylethene photoswitches with either one or two methyl groups at these positions. Depending on the substitution pattern, diarylethenes with one alkyl group can exhibit significant photochromism, but they generally show poor stability towards extended UV irradiation, low thermal stability, and decreased fatigue resistance...
2016: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27322198/efficient-formation-of-site-specific-protein-dna-hybrids-using-copper-free-click-chemistry
#12
Ann Mukhortava, Michael Schlierf
Protein-DNA hybrids have become increasingly popular molecular building blocks in bionanotechnology and single-molecule studies to synergistically combine the programmability of DNA with the chemical diversity of proteins. The growing demand for protein-DNA hybrids requires powerful strategies for their conjugation. Here, we present an efficient two-step method for protein-DNA assembly based on copper-free click chemistry. The method allows site-specificity and high coupling efficiency, while maintaining the conservation of protein activity...
July 20, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27159899/directional-regulation-of-enzyme-pathways-through-the-control-of-substrate-channeling-on-a-dna-origami-scaffold
#13
Guoliang Ke, Minghui Liu, Shuoxing Jiang, Xiaodong Qi, Yuhe Renee Yang, Shaun Wootten, Fei Zhang, Zhi Zhu, Yan Liu, Chaoyong James Yang, Hao Yan
Artificial multi-enzyme systems with precise and dynamic control over the enzyme pathway activity are of great significance in bionanotechnology and synthetic biology. Herein, we exploit a spatially addressable DNA nanoplatform for the directional regulation of two enzyme pathways (G6pDH-MDH and G6pDH-LDH) through the control of NAD(+) substrate channeling by specifically shifting NAD(+) between the two enzyme pairs. We believe that this concept will be useful for the design of regulatory biological circuits for synthetic biology and biomedicine...
June 20, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27151830/metal-ion-induced-self-assembly-of-a-multi-responsive-block-copolypeptide-into-well-defined-nanocapsules
#14
Mark B van Eldijk, Lise Schoonen, Jeroen J L M Cornelissen, Roeland J M Nolte, Jan C M van Hest
Protein cages are an interesting class of biomaterials with potential applications in bionanotechnology. Therefore, substantial effort is spent on the development of capsule-forming designer polypeptides with a tailor-made assembly profile. The expanded assembly profile of a triblock copolypeptide consisting of a metal ion chelating hexahistidine-tag, a stimulus-responsive elastin-like polypeptide block, and a pH-responsive morphology-controlling viral capsid protein is presented. The self-assembly of this multi-responsive protein-based block copolymer is triggered by the addition of divalent metal ions...
May 2016: Small
https://www.readbyqxmd.com/read/27128167/highly-hybridizable-spherical-nucleic-acids-by-tandem-glutathione-treatment-and-polythymine-spacing
#15
Jing Sun, Dennis Curry, Qipeng Yuan, Xu Zhang, Hao Liang
Gold nanoparticle (AuNP)-templated spherical nucleic acids (SNAs) have been demonstrated as an important functional material in bionanotechnology. Fabrication of SNAs having high hybridization capacity to their complementary sequences is critical to ensure their applicability in areas such as antisense gene therapy and cellular sensing. The traditional salt-aging procedure is effective but tedious, requiring 1-3 days to complete. The rapid low-pH assisted protocol is efficient, but causes concerns related to nonspecific DNA adsorption to the AuNP core...
May 18, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27127837/cell-in-shell-hybrids-chemical-nanoencapsulation-of-individual-cells
#16
Ji Hun Park, Daewha Hong, Juno Lee, Insung S Choi
Nature has developed a fascinating strategy of cryptobiosis ("secret life") for counteracting the stressful, and often lethal, environmental conditions that fluctuate sporadically over time. For example, certain bacteria sporulate to transform from a metabolically active, vegetative state to an ametabolic endospore state. The bacterial endospores, encased within tough biomolecular shells, withstand the extremes of harmful stressors, such as radiation, desiccation, and malnutrition, for extended periods of time and return to a vegetative state by breaking their protective shells apart when their environment becomes hospitable for living...
May 17, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27119124/cellular-processing-and-destinies-of-artificial-dna-nanostructures
#17
Di Sheng Lee, Hang Qian, Chor Yong Tay, David Tai Leong
Since many bionanotechnologies are targeted at cells, understanding how and where their interactions occur and the subsequent results of these interactions is important. Changing the intrinsic properties of DNA nanostructures and linking them with interactions presents a holistic and powerful strategy for understanding dual nanostructure-biological systems. With the recent advances in DNA nanotechnology, DNA nanostructures present a great opportunity to understand the often convoluted mass of information pertaining to nanoparticle-biological interactions due to the more precise control over their chemistry, sizes, and shapes...
August 7, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27114062/physical-ingredients-controlling-stability-and-structural-selection-of-empty-viral-capsids
#18
María Aznar, David Reguera
One of the crucial steps in the viral replication cycle is the self-assembly of its protein shell. Typically, each native virus adopts a unique architecture, but the coat proteins of many viruses have the capability to self-assemble in vitro into different structures by changing the assembly conditions. However, the mechanisms determining which of the possible capsid shapes and structures is selected by a virus are still not well-known. We present a coarse-grained model to analyze and understand the physical mechanisms controlling the size and structure selection in the assembly of empty viral capsids...
July 7, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27080924/nanoparticles-and-dna-a-powerful-and-growing-functional-combination-in-bionanotechnology
#19
REVIEW
Anirban Samanta, Igor L Medintz
Functionally integrating DNA and other nucleic acids with nanoparticles in all their different physicochemical forms has produced a rich variety of composite nanomaterials which, in many cases, display unique or augmented properties due to the synergistic activity of both components. These capabilities, in turn, are attracting greater attention from various research communities in search of new nanoscale tools for diverse applications that include (bio)sensing, labeling, targeted imaging, cellular delivery, diagnostics, therapeutics, theranostics, bioelectronics, and biocomputing to name just a few amongst many others...
April 28, 2016: Nanoscale
https://www.readbyqxmd.com/read/27060934/ultrastable-liquid-liquid-interface-as-viable-route-for-controlled-deposition-of-biodegradable-polymer-nanocapsules
#20
Raffaele Vecchione, Giulia Iaccarino, Paolo Bianchini, Roberto Marotta, Francesca D'autilia, Vincenzo Quagliariello, Alberto Diaspro, Paolo A Netti
Liquid-liquid interfaces are highly dynamic and characterized by an elevated interfacial tension as compared to solid-liquid interfaces. Therefore, they are gaining an increasing interest as viable templates for ordered assembly of molecules and nanoparticles. However, liquid-liquid interfaces are more difficult to handle compared to solid-liquid interfaces; their intrinsic instability may affect the assembly process, especially in the case of multiple deposition. Indeed, some attempts have been made in the deposition of polymer multilayers at liquid-liquid interfaces, but with limited control over size and stability...
June 2016: Small
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