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mesenchymal stem cell systemic sclerosis

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https://www.readbyqxmd.com/read/27882538/gene-therapy-with-mesenchymal-stem-cells-expressing-ifn%C3%A3-ameliorates-neuroinflammation-in-experimental-models-of-multiple-sclerosis
#1
C Marin-Bañasco, K Benabdellah, C Melero-Jerez, B Oliver, M J Pinto-Medel, I Hurtado-Guerrero, F de Castro, D Clemente, O Fernández, F Martin, L Leyva, M Suardíaz
BACKGROUND AND PURPOSE: Recombinant IFNß is one of the first line treatments in multiple sclerosis (MS), despite its lack of efficiency in some patients. In this context, mesenchymal stem cells (MSCs) represent a promising therapeutic alternative due to their immunomodulatory properties and multipotency. Moreover, taking advantage of their pathotropism ability, these cells can be genetically modified to be used as carriers for delivering or secreting therapeutic drugs into injured tissues...
November 24, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27714895/gingival-stromal-cells-as-an-in-vitro-model-cannabidiol-modulates-genes-linked-with-amyotrophic-lateral-sclerosis
#2
Thangavelu Soundara Rajan, Domenico Scionti, Francesca Diomede, Gianpaolo Grassi, Federica Pollastro, Adriano Piattelli, Lucio Cocco, Placido Bramanti, Emanuela Mazzon, Oriana Trubiani
Research in recent years has extensively investigated the therapeutic efficacy of mesenchymal stromal cells in regenerative medicine for many neurodegenerative diseases at preclinical and clinical stages. However, the success rate of stem cell therapy remains less at translational phase. Lack of relevant animal models that potentially simulate the molecular etiology of human pathological symptoms might be a reason behind such poor clinical outcomes associated with stem cell therapy. Apparently, self-renewal and differentiation ability of mesenchymal stem cells may help to study the early developmental signaling pathways connected with the diseases, such as Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), etc...
October 7, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27679683/immunomodulation-by-mesenchymal-stem-cells-interplay-between-mesenchymal-stem-cells-and-regulatory-lymphocytes
#3
EDITORIAL
Oscar Ka-Fai Ma, Koon Ho Chan
Mesenchymal stem cells (MSCs) possess immunomodulatory properties, which confer enormous potential for clinical application. Considerable evidence revealed their efficacy on various animal models of autoimmune diseases, such as multiple sclerosis, systemic lupus erythematosus and uveitis. MSCs elicit their immunomodulatory effects by inhibiting lymphocyte activation and proliferation, forbidding the secretion of proinflammatory cytokines, limiting the function of antigen presenting cells, and inducing regulatory T (Treg) and B (Breg) cells...
September 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/27515308/identification-and-validation-of-multiple-cell-surface-markers-of-clinical-grade-adipose-derived-mesenchymal-stromal-cells-as-novel-release-criteria-for-good-manufacturing-practice-compliant-production
#4
Emily T Camilleri, Michael P Gustafson, Amel Dudakovic, Scott M Riester, Catalina Galeano Garces, Christopher R Paradise, Hideki Takai, Marcel Karperien, Simon Cool, Hee-Jeong Im Sampen, A Noelle Larson, Wenchun Qu, Jay Smith, Allan B Dietz, Andre J van Wijnen
BACKGROUND: Clinical translation of mesenchymal stromal cells (MSCs) necessitates basic characterization of the cell product since variability in biological source and processing of MSCs may impact therapeutic outcomes. Although expression of classical cell surface markers (e.g., CD90, CD73, CD105, and CD44) is used to define MSCs, identification of functionally relevant cell surface markers would provide more robust release criteria and options for quality control. In addition, cell surface expression may distinguish between MSCs from different sources, including bone marrow-derived MSCs and clinical-grade adipose-derived MSCs (AMSCs) grown in human platelet lysate (hPL)...
August 11, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27426933/autologous-mesenchymal-stromal-cells-as-a-therapeutic-in-als-and-epilepsy-patients-treatment-modalities-and-ex-vivo-neural-differentiation
#5
REVIEW
Antos Shakhbazau, Michael Potapnev
Stem cell therapy for incurable central nervous system disorders has long been viewed as a promising therapeutic option. In this review, we discuss the existing data and approaches on cell transplantation in the context of the neural differentiation potential of adult autologous stem cells, focusing on those of mesenchymal origin as easily accessible and well studied. Mesenchymal stromal cells (MSCs) are a heterogeneous cell population with a remarkable therapeutic plasticity, demonstrated by their ability to dampen inflammation, inhibit pathogenic immune responses and secrete neuroprotective factors...
October 2016: Cytotherapy
https://www.readbyqxmd.com/read/27335539/clinical-trial-perspective-for-adult-and-juvenile-huntington-s-disease-using-genetically-engineered-mesenchymal-stem-cells
#6
REVIEW
Peter Deng, Audrey Torrest, Kari Pollock, Heather Dahlenburg, Geralyn Annett, Jan A Nolta, Kyle D Fink
Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells (MSC) to secrete brain-derived neurotrophic factor (BDNF) supports our plan to submit an Investigational New Drug application to the Food and Drug Administration for the future planned Phase 1 safety and tolerability trial of MSC/BDNF in patients with Huntington's disease (HD). There are also potential applications of this approach beyond HD. Our biological delivery system for BDNF sets the precedent for adult stem cell therapy in the brain and could potentially be modified for other neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), spinocerebellar ataxia (SCA), Alzheimer's disease, and some forms of Parkinson's disease...
May 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27256975/stem-cell-transplantation-and-mesenchymal-cells-to-treat-autoimmune-diseases
#7
Alan Tyndall, Jacob M van Laar
Since the start of the international stem cell transplantation project in 1997, over 2000 patients have received a haematopoietic stem cell transplant (HSCT), mostly autologous, as treatment for a severe autoimmune disease, the majority being multiple sclerosis (MS), systemic sclerosis (SSc) and Crohn's disease. There was an overall 85% 5-year survival and 43% progression-free survival. Around 30% of patients in all disease subgroups had a complete response, often durable despite full immune reconstitution...
June 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27252423/perivascular-cells-in-diffuse-cutaneous-systemic-sclerosis-overexpress-activated-adam12-and-are-involved-in-myofibroblast-transdifferentiation-and-development-of-fibrosis
#8
Paola Cipriani, Paola Di Benedetto, Piero Ruscitti, Vasiliki Liakouli, Onorina Berardicurti, Francesco Carubbi, Francesco Ciccia, Giuliana Guggino, Francesca Zazzeroni, Edoardo Alesse, Giovanni Triolo, Roberto Giacomelli
OBJECTIVE: Microvascular damage is pivotal in the pathogenesis of systemic sclerosis (SSc), preceding fibrosis, and whose trigger is not still fully understood. Perivascular progenitor cells, with profibrotic activity and function, are identified by the expression of the isoform 12 of ADAM (ADAM12) and this molecule may be upregulated by transforming growth factor-β (TGF-β). The goal of this work was to evaluate whether pericytes in the skin of patients with diffuse cutaneous SSc (dcSSc) expressed ADAM12, suggesting their potential contribution to the fibrotic process, and whether TGF-β might modulate this molecule...
July 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27250994/mesenchymal-stromal-stem-cells-do-not-ameliorate-experimental-autoimmune-encephalomyelitis-and-are-not-detectable-in-the-central-nervous-system-of-transplanted-mice
#9
Pierre Abramowski, Susanne Krasemann, Thomas Ernst, Claudia Lange, Harald Ittrich, Michaela Schweizer, Axel R Zander, Roland Martin, Boris Fehse
Mesenchymal stromal/stem cells (MSCs) constitute progenitor cells that can be isolated from different tissues. Based on their immunomodulatory and neuroprotective functions, MSC-based cell-therapy approaches have been suggested to antagonize inflammatory activity and neuronal damage associated with autoimmune disease of the central nervous system (CNS), for example, multiple sclerosis (MS). Intravenous MSC transplantation was reported to ameliorate experimental autoimmune encephalomyelitis (EAE), the murine model of MS, within days after transplantation...
August 1, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27207172/adipose-derived-mesenchymal-stem-cells-in-autoimmune-disorders-state-of-the-art-and-perspectives-for-systemic-sclerosis
#10
Alexandre T J Maria, Marie Maumus, Alain Le Quellec, Christian Jorgensen, Danièle Noël, Philippe Guilpain
Mesenchymal stromal/stem cells (MSC) are non-hematopoietic multipotent progenitor cells, first described in bone marrow in the middle of last century. Since then, MSC have been the objects of a myriad of publications, progressively increasing our knowledge on their potentialities and bringing high expectancies for their regenerative properties. During the same period, numerous tissues, such as adipose tissue, placenta, or umbilical cord, have been used as alternative sources of MSC in comparison with bone marrow...
May 20, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27158466/update-on-the-pathogenesis-of-scleroderma-focus-on-circulating-progenitor-cells
#11
REVIEW
Alexandra Maria Giovanna Brunasso, Cesare Massone
In systemic sclerosis (SSc), the development of fibrosis seems to be a consequence of the initial ischemic process related to an endothelial injury. The initial trigger event in SSc is still unknown, but circulating progenitor cells (CPCs) might play a key role. Such cells have the ability to traffic into injury sites, exhibiting inflammatory features of macrophages, tissue remodeling properties of fibroblasts, and vasculogenesis functions of endothelial cells. The different subsets of CPCs described thus far in SSc arise from a pool of circulating monocyte precursors (CD14 (+) cells) and probably correspond to a different degree of differentiation of a single cell of origin...
2016: F1000Research
https://www.readbyqxmd.com/read/27052182/human-adipose-mesenchymal-stem-cells-as-potent-anti-fibrosis-therapy-for-systemic-sclerosis
#12
Alexandre T J Maria, Karine Toupet, Marie Maumus, Guillaume Fonteneau, Alain Le Quellec, Christian Jorgensen, Philippe Guilpain, Danièle Noël
OBJECTIVES: Displaying immunosuppressive and trophic properties, mesenchymal stem/stromal cells (MSC) are being evaluated as promising therapeutic options in a variety of autoimmune and degenerative diseases. Although benefits may be expected in systemic sclerosis (SSc), a rare autoimmune disease with fibrosis-related mortality, MSC have yet to be evaluated in this specific condition. While autologous approaches could be inappropriate because of functional alterations in MSC from patients, the objective of the present study was to evaluate allogeneic and xenogeneic MSC in the HOCl-induced model of diffuse SSc...
June 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/26987803/restrained-th17-response-and-myeloid-cell-infiltration-into-the-central-nervous-system-by-human-decidua-derived-mesenchymal-stem-cells-during-experimental-autoimmune-encephalomyelitis
#13
Beatriz Bravo, Marta I Gallego, Ana I Flores, Rafael Bornstein, Alba Puente-Bedia, Javier Hernández, Paz de la Torre, Elena García-Zaragoza, Raquel Perez-Tavarez, Jesús Grande, Alicia Ballester, Sara Ballester
BACKGROUND: Multiple sclerosis is a widespread inflammatory demyelinating disease. Several immunomodulatory therapies are available, including interferon-β, glatiramer acetate, natalizumab, fingolimod, and mitoxantrone. Although useful to delay disease progression, they do not provide a definitive cure and are associated with some undesirable side-effects. Accordingly, the search for new therapeutic methods constitutes an active investigation field. The use of mesenchymal stem cells (MSCs) to modify the disease course is currently the subject of intense interest...
2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/26981093/mesenchymal-stem-cells-require-the-peripheral-immune-system-for-immunomodulating-effects-in-animal-models-of-multiple-sclerosis
#14
Laura Salinas Tejedor, Thomas Skripuletz, Martin Stangel, Viktoria Gudi
No abstract text is available yet for this article.
January 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/26791480/mesenchymal-stem-cells-of-dental-origin-their-potential-for-anti-inflammatory-and-regenerative-actions-in-brain-and-gut-damage
#15
Anna Földes, Kristóf Kádár, Beáta Kerémi, Ákos Zsembery, Klára Gyires, Zoltán S Zádori, Gábor Varga
Alzheimer's disease, Parkinson's disease, traumatic brain and spinal cord injury and neuro inflammatory multiple sclerosis are diverse disorders of the central nervous system. However, they are all characterized by various levels of inappropriate inflammatory/immune response along with tissue destruction. In the gastrointestinal system, inflammatory bowel disease (IBD) is also a consequence of tissue destruction resulting from an uncontrolled inflammation. Interestingly, there are many similarities in the immune patho mechanisms of these CNS disorders and the various forms of IBD...
January 20, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/26765769/human-mesenchymal-stem-cells-genetically-engineered-to-overexpress-brain-derived-neurotrophic-factor-improve-outcomes-in-huntington-s-disease-mouse-models
#16
Kari Pollock, Heather Dahlenburg, Haley Nelson, Kyle D Fink, Whitney Cary, Kyle Hendrix, Geralyn Annett, Audrey Torrest, Peter Deng, Joshua Gutierrez, Catherine Nacey, Karen Pepper, Stefanos Kalomoiris, Johnathon D Anderson, Jeannine McGee, William Gruenloh, Brian Fury, Gerhard Bauer, Alexandria Duffy, Theresa Tempkin, Vicki Wheelock, Jan A Nolta
Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric disease that causes neuronal death and is characterized by progressive striatal and then widespread brain atrophy. Brain-derived neurotrophic factor (BDNF) is a lead candidate for the treatment of HD, as it has been shown to prevent cell death and to stimulate the growth and migration of new neurons in the brain in transgenic mouse models. BDNF levels are reduced in HD postmortem human brain. Previous studies have shown efficacy of mesenchymal stem/stromal cells (MSC)/BDNF using murine MSCs, and the present study used human MSCs to advance the therapeutic potential of the MSC/BDNF platform for clinical application...
May 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/26757144/adipose-derived-mesenchymal-stem-cells-modulate-the-immune-response-in-chronic-experimental-autoimmune-encephalomyelitis-model
#17
REVIEW
Sally M Shalaby, Norhan A Sabbah, Taisir Saber, Reda A Abdel Hamid
Multiple sclerosis (MS) is an autoimmune inflammatory neurodegenerative disease of the central nervous system (CNS) that disrupts the myelin sheath, leading to dysfunction of the brain and spinal cord. No curative treatment is known for MS. Mesenchymal stem cells, through their immunomodulatory effects, represent a promising therapeutic approach for MS. The aim of this article is to explore the impact of human adipose-derived mesenchymal stem cells (ASCs) on chronic experimental autoimmune encephalomyelitis (EAE) model of MS when injected after a disease entered an irreversible clinical course...
February 2016: IUBMB Life
https://www.readbyqxmd.com/read/26729060/alternative-source-of-stem-cells-derived-from-human-periodontal-ligament-a-new-treatment-for-experimental-autoimmune-encephalomyelitis
#18
Oriana Trubiani, Sabrina Giacoppo, Patrizia Ballerini, Francesca Diomede, Adriano Piattelli, Placido Bramanti, Emanuela Mazzon
BACKGROUND: Multiple sclerosis is a demyelinating disease mostly of autoimmune origin that affects and damages the central nervous system, leading to a disabling condition. The aim of the present study was to investigate whether administration of mesenchymal stem cells from human periodontal ligament (hPDLSCs) could ameliorate multiple sclerosis progression by exerting neuroprotective effects in an experimental model of autoimmune encephalomyelitis (EAE). METHODS: EAE was induced by immunization with myelin oligodendroglial glycoprotein peptide (MOG)35-55 in C57BL/6 mice...
January 4, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/26652928/mesenchymal-stem-cells-potential-for-therapy-and-treatment-of-chronic-non-healing-skin-wounds
#19
Giovanni Marfia, Stefania Elena Navone, Clara Di Vito, Nicola Ughi, Silvia Tabano, Monica Miozzo, Carlo Tremolada, Gianni Bolla, Chiara Crotti, Francesca Ingegnoli, Paolo Rampini, Laura Riboni, Roberta Gualtierotti, Rolando Campanella
Wound healing is a complex physiological process including overlapping phases (hemostatic/inflammatory, proliferating and remodeling phases). Every alteration in this mechanism might lead to pathological conditions of different medical relevance. Treatments for chronic non-healing wounds are expensive because reiterative treatments are needed. Regenerative medicine and in particular mesenchymal stem cells approach is emerging as new potential clinical application in wound healing. In the past decades, advance in the understanding of molecular mechanisms underlying wound healing process has led to extensive topical administration of growth factors as part of wound care...
2015: Organogenesis
https://www.readbyqxmd.com/read/26651832/human-mesenchymal-stem-cells-target-adhesion-molecules-and-receptors-involved-in-t-cell-extravasation
#20
Federica Benvenuto, Adriana Voci, Enrico Carminati, Francesca Gualandi, Gianluigi Mancardi, Antonio Uccelli, Laura Vergani
INTRODUCTION: Systemic delivery of bone marrow-derived mesenchymal stem cells (MSC) seems to be of benefit in the treatment of multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) sustained by migration of T cells across the brain blood barrier (BBB) and subsequent induction of inflammatory lesions into CNS. MSC have been found to modulate several effector functions of T cells. In this study, we investigated the effects of MSC on adhesion molecules and receptors on T cell surface that sustain their transendothelial migration...
2015: Stem Cell Research & Therapy
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