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https://www.readbyqxmd.com/read/27911393/a-detailed-protocol-for-perspiration-monitoring-using-a-novel-small-wireless-device
#1
Kazuhiro Ogai, Masakazu Fukuoka, Kei-Ichiro Kitamura, Kiyoshi Uchide, Tetsu Nemoto
Perspiration monitoring can be utilized for the detection of certain diseases, such as thermoregulation and mental disorders, particularly when the patients are unaware of such disorders or are having difficulty expressing their symptoms. Until now, several devices for perspiration monitoring have been developed; however, such devices tend to have a relatively large exterior, considerable power consumption, and/or less sensitivity. Recently, we developed a small, wireless device for perspiration monitoring...
November 24, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27900330/structural-comparison-between-the-right-and-left-atrial-appendages-using-multidetector-computed-tomography
#2
Koichi Shinoda, Shogo Hayashi, Daisuke Fukuoka, Ryo Torii, Tsuneo Watanabe, Takashi Nakano
The three-dimensional (3D) structures of the right atrial appendage (RAA) and left atrial appendage (LAA) were compared to clarify why thrombus formation less frequently occurs in RAA than in LAA. Morphological differences between RAA and LAA of 34 formalin-preserved cadaver hearts were investigated. Molds of RAA and LAA specimens were made and the neck areas, volumes of the atrial appendages (AA), and amount of pectinate muscles (PMs) were analyzed using multidetector computed tomography. In RAA, most PMs were connected to one another and formed a "dendritic" appearance and the inner surface area was smaller than in LAA...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27888870/latest-advances-in-pancreatic-tumours
#3
José Lariño Noia
Pancreatic cancer continues to have a bleak prognosis. Hardly any therapeutic advances have been made in the last few years and consequently most efforts have focused on preventing its development and on diagnosing precursor lesions. In this regard, the use of statins as a preventive factor and the implementation of screening programmes in high-risk patients are gaining ground. In the field of treatment, there is greater focus on the role of neoadjuvant therapy in pancreatic cancer and on a multimodal approach to the disease, with few advances in effective novel therapies...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27872985/pharmacokinetics-and-histopathological-findings-of-chemoembolization-using-cisplatin-powder-mixed-with-degradable-starch-microspheres-in-a-rabbit-liver-tumor-model
#4
Takeshi Sato, Toshihiro Tanaka, Hideyuki Nishiofuku, Yasushi Fukuoka, Hiroshi Sakaguchi, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami, Masato Takano, Ichiro Yamato, Masayuki Sho, Chiho Ohbayashi, Toshiko Hirai, Kimihiko Kichikawa
PURPOSE: The purpose of this study is to evaluate the pharmacokinetics and histopathological findings of transarterial chemoembolization (TACE) using cisplatin powder mixed with degradable starch microspheres (DSM) (Cis/DSM-TACE) compared with cisplatin arterial infusion (Cis-AI). MATERIALS AND METHODS: Eighteen rabbits with VX2 liver tumors were divided into two groups: Cis/DSM-TACE (n = 9) and Cis-AI (n = 9) groups. In the Cis/DSM-TACE group, a mixture of cisplatin powder and DSM was injected until stasis of hepatic arterial flow was achieved...
November 21, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27867528/age-and-sex-related-differences-in-diastolic-function-and-cardiac-dimensions-in-a-hypertensive-population
#5
Shiro Hoshida, Yukinori Shinoda, Kuniyasu Ikeoka, Hidetada Fukuoka, Hirooki Inui, Tetsuya Watanabe
AIMS: The prevalence of left ventricular diastolic dysfunction increases with age, particularly in hypertensive women. We aimed to determine the age- and sex-related differences in diastolic function, and its relation to alterations of cardiac dimensions in a hypertensive population. METHODS AND RESULTS: We enrolled 479 hypertensive patients with a left ventricular ejection fraction (LVEF) ≥50% (men/women, 267/212) and their echocardiographic parameters regarding LV performance and vascular function were measured...
December 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27846765/adult-onset-still-s-disease-like-manifestation-accompanied-by-the-cancer-recurrence-after-long-term-resting-state
#6
Kazuhito Fukuoka, Ayako Miyamoto, Yuko Ozawa, Noriko Ikegaya, Tomohiro Maesono, Yoshinori Komagata, Shinya Kaname, Yoshihiro Arimura
A 72-year-old woman presented nine months ago with skin rash on her bilateral forearms, which was followed by intermittent high fever, and stiffness and swelling of her bilateral fingers. She was diagnosed with seronegative rheumatoid arthritis (RA). She had a past history of breast cancer and had undergone breast preservation surgery 13 years previously. During admission in our hospital, she developed high fever and leukocytosis with a relapsing skin rash, sore throat, polyarthralgia and increased levels of serum ALT/AST and ferritin, all of which fulfilled Yamaguchi's criteria for adult-onset Still's disease (AOSD)...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27830830/ethnic-differences-in-glucose-homeostasis-markers-between-the-kyushu-okinawa-population-study-and-the-framingham-offspring-study
#7
Hiroaki Ikezaki, Masumi Ai, Ernst J Schaefer, Seiko Otokozawa, Bela F Asztalos, Katsuyuki Nakajima, Yanhua Zhou, Ching-Ti Liu, Paul F Jacques, L Adrienne Cupples, Norihiro Furusyo
We compared markers of glucose homeostasis and their association with diabetes and impaired fasting glucose (IFG) in Fukuoka, Japanese subjects (n = 1108) and age-, gender- and menopausal status-matched participants in the Framingham Offspring Study (n = 1096). The markers examined included fasting glucose, insulin, adiponectin, and glycated albumin, as well as body mass index (BMI), use of medications, and history of diabetes. The results showed that IFG prevalence in Japanese men (15.9%) and women (7...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27820747/the-impact-of-age-related-cataract-on-measures-of-frailty-in-an-aging-global-population
#8
Hideki Fukuoka, Natalie A Afshari
PURPOSE OF REVIEW: To review the associations among age-related cataract, frailty, and frailty outcomes (e.g., disabilities). RECENT FINDINGS: It is predicted that the proportion of the population aged 65 and older, in developed and developing nations alike, will rise until at least 2050. The proportion of patients suffering from cataracts and frailty is expected to increase, as are age-related diseases. Although there are many papers reporting on the association between frailty outcomes, cataract, and visual impairment, there is a relative paucity of papers describing associations between frailty markers, cataract, and visual impairment...
January 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27811333/short-term-exposure-to-fine-particulate-matter-and-risk-of-ischemic-stroke
#9
Ryu Matsuo, Takehiro Michikawa, Kayo Ueda, Tetsuro Ago, Hiroshi Nitta, Takanari Kitazono, Masahiro Kamouchi
BACKGROUND AND PURPOSE: There is a strong association between ambient concentrations of particulate matter (PM) and cardiovascular disease. However, it remains unclear whether acute exposure to fine PM (PM2.5) triggers ischemic stroke events and whether the timing of exposure is associated with stroke risk. We, therefore, examined the association between ambient PM2.5 and occurrence of ischemic stroke. METHODS: We analyzed data for 6885 ischemic stroke patients from a multicenter hospital-based stroke registry in Japan who were previously independent and hospitalized within 24 hours of stroke onset...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27799653/-reboa-is-it-really-safe-a-case-with-massive-intracranial-hemorrhage-possibly-due-to-endovascular-balloon-occlusion-of-the-aorta-reboa
#10
Hayaki Uchino, Nobuichiro Tamura, Ryosuke Echigoya, Tetsunori Ikegami, Toshio Fukuoka
BACKGROUND Non-compressible torso hemorrhage continues to be the leading cause of preventable death in trauma patients. Recent case series report that resuscitative endovascular balloon occlusion of the aorta (REBOA) in the trauma population is a technically feasible method to manage the patients with exsanguinating hemorrhage. On the other hand, it seems that REBOA is being widely promoted prematurely. Complications due to REBOA haven't been reported much in the literature, and they could have been underestimated...
November 1, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27799141/survival-of-lung-adenocarcinoma-patients-predicted-from-expression-of-pd-l1-galectin-9-and-xage1-gaged2a-on-tumor-cells-and-tumor-infiltrating-t-cells
#11
Yoshihiro Ohue, Koji Kurose, Ryohei Nozawa, Midori Isobe, Yumi Nishio, Tomonori Tanaka, Yoshinori Doki, Takashi Hori, Junya Fukuoka, Mikio Oka, Eiichi Nakayama
The immune status of tumors varies, and this may affect the overall survival (OS) of patients. We examined tumors from 120 patients with lung adenocarcinomas with a tissue microarray for T-cell infiltration and the expression of PD-L1 and Galectin-9 (both ligands for inhibitory receptors on T cells), and cancer/testis (CT) antigen XAGE1 (GAGED2a; a tumor antigen often found on lung tumors) expression, to determine their relevance to OS. Patients defined as pStage I-IIIA could be grouped, based on the expression profiles of PD-L1, Galectin-9, and XAGE1, into cluster A, who had prolonged survival, and cluster B, who had shorter survival...
December 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27798874/prognostic-significance-of-microrna-21-expression-in-patients-with-unresectable-metastatic-colon-cancer
#12
Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Tetsuro Ikeya, Shinji Matsutani, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira
BACKGROUND/AIM: MicroRNA (miR)-21 is overexpressed in most solid tumors and a high expression of miR-21 in tumor tissue is associated with a poor clinical outcome. The aim of this study was to clarify the association between the miR-21 expression in the tumor and the chemotherapeutic outcomes and survival for unresectable metastatic colon cancer (CC). MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded (FFPE) samples of primary tumor were obtained from 32 patients who underwent primary tumor resection and received palliative chemotherapy for unresectable metastatic CC...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27793846/molecular-chaperone-hsp90-is-necessary-to-prevent-cellular-senescence-via-lysosomal-degradation-of-p14arf
#13
Su Yeon Han, Aram Ko, Haruhisa Kitano, Chel Hun Choi, Min-Sik Lee, Jinho Seo, Junya Fukuoka, Soo-Youl Kim, Stephen M Hewitt, Joon-Yong Chung, Jaewhan Song
The tumor suppressor function of p14ARF is regulated at a post-translational level via mechanisms yet to be fully understood. Here we report the identification of an unconventional p14ARF degradation pathway induced by the chaperone HSP90 in association with the E3 ubiquitin ligase CHIP. The ternary complex of HSP90, CHIP and p14ARF was required to induce the lysosomal degradation of p14ARF by a ubiquitination-independent but LAMP2A-dependent mechanism. Depletion of HSP90 or CHIP induced p14ARF-dependent senescence in human fibroblasts...
October 28, 2016: Cancer Research
https://www.readbyqxmd.com/read/27780748/prophylactic-use-of-oral-dexamethasone-to-alleviate-fatigue-during-regorafenib-treatment-for-patients-with-metastatic-colorectal-cancer
#14
Shota Fukuoka, Kohei Shitara, Masaaki Noguchi, Akihito Kawazoe, Yasutoshi Kuboki, Hedeaki Bando, Wataru Okamoto, Takashi Kojima, Toshihiko Doi, Atsushi Ohtsu, Takayuki Yoshino
BACKGROUND: Fatigue is the most common toxicity of all grade toxicities with regorafenib, was the second most common toxicity in the CORRECT (regorafenib monotherapy for previously treated metastatic colorectal cancer) study, and is a major reason for early dose modification. The results from a recent randomized study suggested that dexamethasone (DEX) can improve cancer-related fatigue. PATIENTS AND METHODS: We retrospectively analyzed the effect of prophylactic use of an oral DEX on fatigue during regorafenib treatment in patients with metastatic colorectal cancer (mCRC)...
August 18, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27776043/risk-factors-for-malignancy-of-branch-duct-intraductal-papillary-mucinous-neoplasms-a-critical-evaluation-of-the-fukuoka-guidelines-with-a-systematic-review-and-meta-analysis
#15
Claudio Ricci, Riccardo Casadei, Giovanni Taffurelli, Elia Zani, Nico Pagano, Carlo Alberto Pacilio, Carlo Ingaldi, Selene Bogoni, Donatella Santini, Marina Migliori, Mariacristina Di Marco, Carla Serra, Lucia Calculli, Roberto De Giorgio, Francesco Minni
OBJECTIVES: This study aimed to evaluate the accuracy of the risk factors proposed by Fukuoka guidelines in detecting malignancy of branch-duct intraductal papillary mucinous neoplasms. METHOD: Diagnostic meta-analysis of cohort studies. A systematic literature search was conducted using MEDLINE, the Cochrane Library, Scopus, and the ISI-Web of Science databases to identify all studies published up to 2014. RESULTS: Twenty-five studies (2025 patients) were suitable for the meta-analysis...
October 2016: Pancreas
https://www.readbyqxmd.com/read/27744292/walking-economy-at-simulated-high-altitude-in-human-healthy-young-male-lowlanders
#16
Masahiro Horiuchi, Yoko Handa, Daijiro Abe, Yoshiyuki Fukuoka
We measured oxygen consumption during walking per unit distance (Cw) values for 12 human healthy young males at six speeds from 0.667 to 1.639 m s(-1) (four min per stage) on a level gradient under normobaric normoxia, moderate hypoxia (15% O2), and severe hypoxia (11% O2). Muscle deoxygenation (HHb) was measured at the vastus lateralis muscle using near-infrared spectroscopy. Economical speed which can minimize the Cw in each individual was calculated from a U-shaped relationship. We found a significantly slower economical speed (ES) under severe hypoxia [1...
October 15, 2016: Biology Open
https://www.readbyqxmd.com/read/27743415/targeted-use-of-prednisolone-with-second-ivig-for-refractory-kawasaki-disease
#17
Mitsuaki Kimura, Masashi Harazaki, Tetsuya Fukuoka, Isao Asakura, Hidemasa Sakai, Tsutomu Kamimaki, Ichiro Ohkawara, Naoe Akiyama, Satoshi Tsurui, Satoru Iwashima, Masaki Shimomura, Hideaki Morishita, Takaaki Meguro, Shiro Seto
BACKGROUND: Prednisolone (PSL) has been suggested to be useful for the treatment of patients with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG). However, much remains to be elucidated regarding its proper use. METHODS: Two-stage multicenter prospective studies involving 1,087 subjects were performed to study the effects of acute phase therapy on IVIG-resistant KD. Subjects resistant to the first dose of IVIG were classified into high (≥ 10 mg/dL) and low (< 10 mg/dL) CRP groups according to serum CRP levels after the first dose of IVIG...
October 15, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27742059/cxcl1-chemokine-c-x-c-motif-receptor-2-signaling-stimulates-the-recruitment-of-bone-marrow-derived-mesenchymal-cells-into-diffuse-type-gastric-cancer-stroma
#18
Hiroaki Kasashima, Masakazu Yashiro, Hirohisa Nakamae, Kisyu Kitayama, Go Masuda, Haruhito Kinoshita, Tatsunari Fukuoka, Tsuyoshi Hasegawa, Takahiko Nakane, Masayuki Hino, Kosei Hirakawa, Masaichi Ohira
Tumor stromal cells play a critical role in the progression of diffuse-type gastric cancer (DGC). The aim of this study was to clarify where tumor stromal cells originate from and which factor(s) recruits them into the tumor stroma. Immunodeficient mice with bone marrow transplantation from the cytomegalovirus enhancer/chicken β-actin promoter-enhanced green fluorescent protein mice were used for the in vivo experiments. An in vitro study analyzed the chemotaxis-stimulating factor from DGC cells using bone marrow-derived mesenchymal cells (BM-MCs)...
October 8, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27725548/drug-induced-pneumonitis-following-the-administration-of-tas-102
#19
Yoshikazu Hasegawa, Takayo Ota, Hiroshi Tsukuda, Tomohiro Suzumura, Masahiro Fukuoka
A 59-year-old woman, diagnosed with advanced rectal cancer, presented with a low-grade fever and dyspnea on exertion after the 2nd cycle of TAS-102. TAS-102 has promising efficacy in patients with metastatic colorectal cancer. A CT scan revealed mosaic patterns with bilateral ground-glass opacities. The drug lymphocyte stimulation test for TAS-102 was strongly positive and serum β-D glucan level was elevated. The clinical course was compatible with TAS-102-induced pneumonitis combined with pneumocystis pneumonia (PCP)...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27725420/molecular-mechanism-of-developmental-origins-of-health-and-disease-dohad
#20
Hideoki Fukuoka, Fumihiro Sata
Epigenetic modification takes place in many types of environment. Undesirable epigenetic changes for the postnatal life at the developmental stage are induced in utero by exposure to harsh environment such as endocrine disruptors, severe psychological stress and insufficient or excessive nutrition. Some of these changes continues even for a long time after birth from womb to tomb. Under these circumstances with an unhealthy life style, such as higher caloric intake, insufficient exercise, or stress, there is a higher risk of developing various illnesses including lifestyle-related diseases, such as essential hypertension, type 2 diabetes mellitus, dyslipidemia, psychological disorders and cancers...
2016: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
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