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https://www.readbyqxmd.com/read/29342127/enhancement-in-corneal-permeability-of-dissolved-carteolol-by-its-combination-with-magnesium-hydroxide-nanoparticles
#1
Noriaki Nagai, Sakie Yamaoka, Yuya Fukuoka, Miyu Ishii, Hiroko Otake, Kazutaka Kanai, Norio Okamoto, Yoshikazu Shimomura
We prepared magnesium hydroxide (MH) nanoparticles, and investigated their effect when combined with dissolved carteolol on the bioavailability and intraocular pressure (IOP)-reducing effect of carteolol. The carteolol was solved in saline containing additives (0.5% methylcellulose, 0.001% benzalkonium chloride, 0.5% mannitol; CRT-solution). MH nanoparticles were prepared by a bead mill method with additives. Then carteolol/MH microparticle and carteolol/MH nanoparticle fixed combinations (mCMFC and nCMFC) were prepared by mixing the CRT-solution and MH particles...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29328238/2%C3%A2-%C3%A2-%C3%AE-m-doppler-wind-lidar-with-a-tm-fiber-laser-pumped-ho-ylf-laser
#2
Kohei Mizutani, Shoken Ishii, Makoto Aoki, Hironori Iwai, Ryohei Otsuka, Hirotake Fukuoka, Takayoshi Isikawa, Atsushi Sato
A 2 μm Ho-doped ytrrium lithium fluoride (Ho:YLF) laser end-pumped by a 1.94 μm Tm:fiber laser was developed. A laser system of a ring resonator oscillator and amplifier was operated at repetition rates of 200-5000 Hz at room temperature. The Q-switched outputs were 7.4 W at 5000 Hz and 4.25 W at 200 Hz. Injection seeding was applied to the ring resonator, and single-mode laser emission was obtained. The Tm:fiber-laser-pumped Ho:YLF laser was first used for Doppler wind lidar measurements, and wind profiles were obtained up to ranges of about 15 km in a range resolution of 96 m and an integration time of 1 s...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29323878/electrical-matching-at-metal-molecule-contacts-for-efficient-heterogeneous-charge-transfer
#3
Shino Sato, Shigeru Iwase, Kotaro Namba, Tomoya Ono, Kenji Hara, Atsushi Fukuoka, Kohei Uosaki, Katsuyoshi Ikeda
In a metal/molecule hybrid system, unavoidable electrical mismatch exists between metal continuum states and frontier molecular orbitals. This causes energy loss in the electron conduction across the metal/molecule interface. For efficient use of energy in a metal/molecule hybrid system, it is necessary to control interfacial electronic structures. Here we demonstrate that electrical matching between a gold substrate and π-conjugated molecular wires can be obtained by using monoatomic foreign metal interlayers, which can change the degree of d-π* back donation at metal/anchor contacts...
January 11, 2018: ACS Nano
https://www.readbyqxmd.com/read/29317979/a-case-of-multifaceted-assessment-in-an-elderly-patient-with-acute-decompensated-heart-failure
#4
Hideto Sako, Midori Miyazaki, Yasunori Suematsu, Rie Koyoshi, Yuhei Shiga, Takashi Kuwano, Ken Kitajima, Atsushi Iwata, Katsura Yorinaga, Kanta Fujimi, Shin-Ichiro Miura
Heart failure (HF) is a common health problem worldwide, including in Japan. Unfortunately, patient outcomes remain poor, with a 5-year survival rate of approximately 50%. Therefore, we need to assess the precise conditions, including cardiac function, in patients with HF, particularly in the elderly. We performed a multifaceted assessment in an elderly patient with HF on admission and at discharge using eight different evaluations (the mean life expectancy using the Seattle Heart Failure Model (SHFM), the severity of dementia, nutrition, medication adherence, biomarker (the level of brain natriuretic peptide in blood), sociality, performance and comorbidity)...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29314767/laparoscopic-repair-of-bowel-herniation-into-the-space-between-the-obturator-nerve-and-the-umbilical-artery-after-pelvic-lymphadenectomy-for-cervical-cancer
#5
Hironori Minami, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Yoshiya Fujimoto, Satoshi Nagayama, Yosuke Fukunaga, Hironori Fukuoka, Masashi Ueno
Bowel herniation through the space between the exposed structures after pelvic lymphadenectomy is a very rare cause of postoperative bowel obstruction. Here, a case of laparoscopic release of bowel migration into the space after pelvic lymphadenectomy is described. This is the seventh such reported case in the world. A 38-year-old woman who had a history of undergoing laparoscopic radical hysterectomy and bilateral pelvic lymphadenectomy for cervical cancer was diagnosed with strangulated bowel obstruction...
January 4, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29311456/-a-survey-of-the-adverse-effects-and-influence-of-concomitant-drugs-for-methotrexate-intrathecal-administration
#6
Masanobu Uchiyama, Miho Ueno, Yasushi Takamatsu, Koichi Matsuo, Osamu Imakyure, Hidetoshi Kamimura
 In general, the intraventricular administration of cytotoxic antitumor drugs provides a high drug concentration in the cerebrospinal fluid with a reduced risk of systemic adverse reactions. Methotrexate (MTX) high-dose therapy requires close monitoring when performed in combination with trimethoprim-sulfamethoxazole (ST) therapy and proton pump inhibitor (PPI) and nonsteroidal anti-inflammatory drug administration for excretion delay and toxicity enhancement. While the frequency of systemic side effects is thought to be low with intrathecal administration, such effects do rarely but occasionally occur...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29295981/circulating-exosomes-suppress-the-induction-of-regulatory-t-cells-via-let-7i-in-multiple-sclerosis
#7
Kimitoshi Kimura, Hirohiko Hohjoh, Masashi Fukuoka, Wakiro Sato, Shinji Oki, Chiharu Tomi, Hiromi Yamaguchi, Takayuki Kondo, Ryosuke Takahashi, Takashi Yamamura
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system. Foxp3+ regulatory T (Treg) cells are reduced in frequency and dysfunctional in patients with MS, but the underlying mechanisms of this deficiency are unclear. Here, we show that induction of human IFN-γ-IL-17A-Foxp3+CD4+ T cells is inhibited in the presence of circulating exosomes from patients with MS. The exosomal miRNA profile of patients with MS differs from that of healthy controls, and let-7i, which is markedly increased in patients with MS, suppresses induction of Treg cells by targeting insulin like growth factor 1 receptor (IGF1R) and transforming growth factor beta receptor 1 (TGFBR1)...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29291522/aqueous-and-organic-extract-of-pm2-5-collected-in-different-seasons-and-cities-of-japan-differently-affect-respiratory-and-immune-systems
#8
Pratiti Home Chowdhury, Hitoshi Okano, Akiko Honda, Hitomi Kudou, Gaku Kitamura, Sho Ito, Kayo Ueda, Hirohisa Takano
Particulate matter with diameters <2.5 μm (i.e., PM2.5) has multiple natural and anthropological sources. The association between PM2.5 and the exacerbation of respiratory allergy and asthma has been well studied, but the components of PM2.5 that are responsible for allergies have not yet been determined. Here, we elucidated the effects of aqueous and organic extract of PM2.5 collected during four seasons in November 2014-December 2015 in two cities (Kawasaki, an industrial area and Fukuoka, an urban area affected by transboundary pollution matter) of Japan on respiratory health...
December 28, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29288851/flat-posterior-cranial-fossa-affects-outcomes-of-microvascular-decompression-for-trigeminal-neuralgia
#9
Toshiki Fukuoka, Yusuke Nishimura, Masahito Hara, Kei Nomura, Hiroshi Ryu, Satoshi Yoshikawa, Toshihiko Wakabayashi
OBJECTIVE: The aim of this study was to investigate prognostic factors for microvascular decompression (MVD) in patients with primary trigeminal neuralgia (TN), with a particular focus on the morphology of the posterior cranial fossa (PCF). METHODS: The present study investigated 126 surgically treated primary TN patients with more than 1-year follow-up who underwent high-resolution magnetic resonance imaging between April 2003 and September 2015. We retrospectively reviewed clinical information and operative findings...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29282038/the-prognostic-value-of-tp53-mutations-in-hypopharyngeal-squamous-cell-carcinoma
#10
Go Omura, Mizuo Ando, Yasuhiro Ebihara, Yuki Saito, Kenya Kobayashi, Osamu Fukuoka, Ken Akashi, Masafumi Yoshida, Takahiro Asakage, Tatsuya Yamasoba
BACKGROUND: TP53 is the most frequently mutated gene in human cancers. Previous studies reported that TP53 mutations correlated with poor prognoses in patients with head and neck squamous cell carcinoma (HNSCC). However, the relationship between TP53 mutations and hypopharyngeal squamous cell carcinoma (HPSCC) is not known. The current study aimed to evaluate TP53 mutation status as a predictive biomarker in patients with HPSCC. METHODS: We retrospectively reviewed the clinical charts of 57 HPSCC patients treated with initial surgery between 2008 and 2014...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29279303/fine-mapping-of-quick-rooting1-and-2-quantitative-trait-loci-increasing-root-length-in-rice
#11
Yuka Kitomi, Emari Nakao, Sawako Kawai, Noriko Kanno, Tsuyu Ando, Shuichi Fukuoka, Kenji Irie, Yusaku Uga
The volume that the root system can occupy is associated with the efficiency of water and nutrient uptake from soil. Genetic improvement of root length, which is a limiting factor for root distribution, is necessary for increasing crop production. In this report, we describe identification of two QTLs for maximal root length, QUICK ROOTING 1 (QRO1) on chromosome 2 and QRO2 on chromosome 6 in cultivated rice (Oryza sativa L.). We measured the maximal root length in 26 lines carrying chromosome segments from the long-rooted upland rice cultivar Kinandang Patong in the genetic background of the short-rooted lowland cultivar IR64...
December 26, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29275313/tumor-infiltrating-lymphocytes-predict-the-chemotherapeutic-outcomes-in-patients-with-stage-iv-colorectal-cancer
#12
Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Yasuhito Iseki, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa, Masaichi Ohira
BACKGROUND/AIM: The anticancer immune response has been reported to contribute to the success of chemotherapy. The aim of this study was to evaluate the significance of the measurement of tumor-infiltrating lymphocytes (TILs) in the primary tumor using the method proposed by the International TILs Working Group as a prognostic marker of chemotherapeutic outcomes in patients with stage IV colorectal cancer (CRC). PATIENTS AND METHODS: A total of 57 patients with stage IV CRC who underwent palliative chemotherapy after resection of the primary tumor were enrolled...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29274060/biosynthesis-of-mono-acylated-mannosylerythritol-lipid-in-an-acyltransferase-gene-disrupted-mutant-of-pseudozyma-tsukubaensis
#13
Azusa Saika, Yu Utashima, Hideaki Koike, Shuhei Yamamoto, Takahide Kishimoto, Tokuma Fukuoka, Tomotake Morita
The basidiomycetous yeast genus Pseudozyma produce large amounts of mannosylerythritol lipids (MELs), which are biosurfactants. A few Pseudozyma strains produce mono-acylated MEL as a minor compound using excess glucose as the sole carbon source. Mono-acylated MEL shows higher hydrophilicity than di-acylated MEL and has great potential for aqueous applications. Recently, the gene cluster involved in the MEL biosynthesis pathway was identified in yeast. Here, we generated an acyltransferase (PtMAC2) deletion strain of P...
December 23, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29259803/preliminary-evidence-supports-circulating-micrornas-as-prognostic-biomarkers-for-type-2-diabetes
#14
E Flowers, A M Kanaya, Y Fukuoka, I E Allen, B Cooper, B E Aouizerat
Background: Circulating microRNAs are emerging as potential prognostic biomarkers for the development of type 2 diabetes. However, microRNAs are also associated with complications from impaired glucose metabolism (e.g. endothelial cell function). Prior studies have not evaluated for associations between trajectories of circulating microRNAs with trajectories of fasting blood glucose over time and the responses to behavioral interventions to reduce risk. This study performed longitudinal assessment of microRNAs and fasting blood glucose and identified relationships between microRNAs and behavioral risk reduction interventions...
December 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/29247350/development-of-pumping-emulsification-device-with-glass-membrane-to-form-ideal-lipiodol-emulsion-in-transarterial-chemoembolization
#15
Toshihiro Tanaka, Tetsuya Masada, Hideyuki Nishiofuku, Yasushi Fukuoka, Takeshi Sato, Shota Tatsumoto, Nagaaki Marugami, Shushi Higashi, Kimihiko Kichikawa
PURPOSE: To evaluate a pumping emulsification device that can improve the physiochemical properties and stability of lipiodol emulsion for conventional transarterial chemoembolization. MATERIALS AND METHODS: A pumping emulsification device constructed of a glass membrane with a hydrophobic surface with pore size of 50 μm in diameter was placed between two syringe adaptors. Epirubicin solutions were mixed with lipiodol with pumping exchanges using the emulsification device or a three-way cock...
December 15, 2017: European Radiology
https://www.readbyqxmd.com/read/29243002/comprehending-the-three-dimensional-mandibular-morphology-of-facial-asymmetry-patients-with-mandibular-prognathism
#16
Hideki Kamata, Norihisa Higashihori, Hiroki Fukuoka, Momotoshi Shiga, Tatsuo Kawamoto, Keiji Moriyama
BACKGROUND: The purpose of this study was to elucidate the factors that cause facial asymmetry by comparing the characteristics of the mandibular morphology in patients with mandibular prognathism with or without facial asymmetry using three-dimensional computed tomography (3D-CT). METHODS: We studied 28 mandibular prognathism patients whose menton deviated by ≥ 4 mm from the midline (FA group, n = 14) and those with a < 4-mm deviation (NA group, n = 14)...
December 15, 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/29239011/relationship-between-serum-anti-varicella-zoster-virus-antibody-titer-and-time-from-onset-of-herpes-zoster
#17
Honoka Ihara, Motoko Miyachi, Shinichi Imafuku
Herpes zoster is an internal reactivation of varicella zoster virus, and its onset depends on immunity against this virus. We have previously reported that antiviral antibody titers are inversely correlated with patient numbers. In this study, we hypothesized that patients with higher titers may be late visitors to the clinic, whose antibodies were already boosted at presentation because of the time lapse between onset of zoster and measurement of antibodies. We analyzed antibody titers of patients with acute herpes zoster who visited Fukuoka University Hospital from January 2009 to May 2016 (n = 141, 62 males and 79 females)...
December 14, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29233789/predictive-performance-of-four-programmed-cell-death-ligand-1-assay-systems-on-nivolumab-response-in-previously-treated-patients-with-non-small-cell-lung-cancer
#18
Daichi Fujimoto, Yuki Sato, Keiichiro Uehara, Kaori Ishida, Junya Fukuoka, Takeshi Morimoto, Hayato Kawachi, Ryobu Mori, Munehiro Ito, Shunsuke Teraoka, Kazuma Nagata, Atsushi Nakagawa, Kojiro Otsuka, Yukihiro Imai, Keisuke Tomii
INTRODUCTION: Nivolumab has demonstrated efficacy against metastatic non-small cell lung cancer (NSCLC). Four programmed cell death ligand 1 (PD-L1) immunohistochemistry (IHC) assay systems are available for identification of responders among patients with NSCLC, and these assays show some differing characteristics. Accordingly, in this study, we evaluated the ability of these assays to identify responders to nivolumab therapy. METHODS: We retrospectively analyzed patients with previously treated advanced NSCLC, who received nivolumab between January 2016 and September 2016...
December 9, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29233102/the-gene-treatment-interaction-of-paraoxonase-1-gene-polymorphism-and-statin-therapy-on-insulin-secretion-in-japanese-patients-with-type-2-diabetes-fukuoka-diabetes-registry
#19
Akiko Sumi, Udai Nakamura, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Yuji Komorita, Masahito Yoshinari, Yoichiro Hirakawa, Atsushi Hirano, Michiaki Kubo, Takanari Kitazono
BACKGROUND: Although statins deteriorate glucose metabolism, their glucose-lowering effects have emerged in some situations. Here, we assessed whether these effects are a consequence of statins' interaction with paraoxonase (PON)1 enzyme polymorphism. METHODS: Adult Japanese type 2 diabetes patients (n = 3798) were enrolled in a cross-sectional study. We used Q192R polymorphism of the PON1 gene as a representative single-nucleotide polymorphism and focused on the effects of the wild-type Q allele, in an additive manner...
December 12, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29205682/sibling-visitations-and-viral-infections-in-the-neonatal-intensive-care-unit
#20
Yuho Horikoshi, Kaoru Okazaki, Shigeko Miyokawa, Kazue Kinoshita, Hiroshi Higuchi, Junichi Suwa, Yuta Aizawa, Kahoru Fukuoka
BACKGROUND: Sibling visitations to the neonatal intensive care unit (NICU) are a part of family-centered care, which is now being increasingly endorsed as a positive development in patient care. However, sibling visitations pose a risk of viral infections such that many NICUs in Japan impose strict limits on the practice. The aim of our study was to assess whether sibling visitations to the NICU are related to an increase in the nosocomial viral infection rate. METHODS: This retrospective study was conducted between April 2012 and March 2017 at Tokyo Metropolitan Children's Medical Center in Japan...
December 5, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
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