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https://www.readbyqxmd.com/read/28646688/solar-radiation-and-out-of-hospital-cardiac-arrest-in-japan
#1
Daisuke Onozuka, Akihito Hagihara
BACKGROUND: Although several studies have estimated the effects of temperature on mortality and morbidity, little is known regarding the burden of out-of-hospital cardiac arrest (OHCA) attributable to solar radiation. METHODS: We obtained data for all cases of OHCA and meteorological data reported between 2011 and 2014 in 3 Japanese prefectures: Hokkaido, Ibaraki, and Fukuoka. We first examined the relationship between daily solar radiation and OHCA risk for each prefecture using time-varying distributed lag non-linear models and then pooled the results in a multivariate random-effects meta-analysis...
June 21, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28628504/morphology-and-function-of-meibomian-glands-and-other-tear-film-parameters-in-junior-high-school-students
#2
Takanori Mizoguchi, Reiko Arita, Shima Fukuoka, Naoyuki Morishige
PURPOSE: We measured tear film parameters, including the morphology and function of meibomian glands, in junior high school students at 15 years of age. METHODS: A total of 111 eyes of 111 students (56 males and 55 females) were enrolled in the study. The ocular symptom score (0-14), after-school study time, lipid layer thickness (LLT) of the tear film, partial blink rate, lid margin abnormalities (0-4), tear film breakup time, corneal and conjunctival epithelial damage (fluorescein staining score, 0-9), meiboscore as determined by noncontact meibography (0-6), Schirmer test value, and meibum grade (0-3) were determined...
June 14, 2017: Cornea
https://www.readbyqxmd.com/read/28623914/synaptonemal-complex-protein-3-is-associated-with-lymphangiogenesis-in-non-small-cell-lung-cancer-patients-with-lymph-node-metastasis
#3
Haruhisa Kitano, Joon-Yong Chung, Kyung Hee Noh, Young-Ho Lee, Tae Woo Kim, Seok Hyung Lee, Soo-Heang Eo, Hyung Jun Cho, Chel Hun Choi, Shuhei Inoue, Jun Hanaoka, Junya Fukuoka, Stephen M Hewitt
BACKGROUND: The interaction of vascular endothelial growth factor-C (VEGF-C)/VEGF-D/VEGF receptor-3 is considered to be a major driver of lymphangiogenesis, however the mechanism of this process remains unclear. We aimed to investigate the possible lymphangiogenic significance of synaptonemal complex protein 3 (SCP3) in non-small cell lung cancer (NSCLC). METHODS: The expression of SCP3, VEGF-C, and VEGF-D were measured and examined a correlation between SCP3 and VEGF-C or VEGF-D in various human lung cancer cell lines...
June 17, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28620220/coupling-killing-to-neutralization-combined-therapy-with-ceftriaxone-pep19-2-5-counteracts-sepsis-in-rabbits
#4
Sergio Bárcena-Varela, Guillermo Martínez-de-Tejada, Lukas Martin, Tobias Schuerholz, Ana Gloria Gil-Royo, Satoshi Fukuoka, Torsten Goldmann, Daniel Droemann, Wilmar Correa, Thomas Gutsmann, Klaus Brandenburg, Lena Heinbockel
Sepsis, which is induced by severe bacterial infections, is a major cause of death worldwide, and therapies combating the disease are urgently needed. Because many drugs have failed in clinical trials despite their efficacy in mouse models, the development of reliable animal models of sepsis is in great demand. Several studies have suggested that rabbits reflect sepsis-related symptoms more accurately than mice. In this study, we evaluated a rabbit model of acute sepsis caused by the intravenous inoculation of Salmonella enterica...
June 16, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28619796/draft-genome-sequence-of-campylobacter-jejuni-cam970-and-c-%C3%A2-coli-cam962-associated-with-a-large-outbreak-of-foodborne-illness-in-fukuoka-japan-in-2016
#5
Hiroshi Asakura, Naoto Takahashi, Shiori Yamamoto, Hiroyuki Maruyama
Here, we report the draft genome sequences of Campylobacter jejuni CAM970 and C. coli CAM962, which were associated with a large outbreak of foodborne illness originating from undercooked chicken sushi in Fukuoka, Japan, in May 2016. Their genome sizes were 1,690,901 and 1,704,736 bp, with 22 and 23 rRNAs, 9 and 9 tRNAs, and 411× and 419× coverage for C. jejuni CAM970 and C. coli CAM962, respectively.
June 15, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28615923/changes-in-meibomian-gland-morphology-and-ocular-higher-order-aberrations-in-eyes-with-chalazion
#6
Shima Fukuoka, Reiko Arita, Rika Shirakawa, Naoyuki Morishige
PURPOSE: To examine the changes in meibomian gland morphology and ocular higher-order aberrations (HOAs) in eyes with chalazion and its excision. METHODS: Seven male patients with previous history of chalazion excision and seven control male subjects were enrolled. Changes in meibomian gland morphology (meiboscores, gland dropout, and shortening) were evaluated by using meibography equipped in a wavefront analyzer KR-1W and in a slit-lamp device BG-4M. Ocular HOAs were measured sequentially with KR-1W...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28602321/changes-in-corneal-astigmatism-during%C3%A2-20%C3%A2-years-after-cataract-surgery
#7
Ken Hayashi, Shin-Ichi Manabe, Akira Hirata, Koichi Yoshimura
PURPOSE: To examine how corneal astigmatism changes with age over 20 years after cataract surgery and to assess whether the changes differ from those in eyes that did not have surgery. SETTING: Hayashi Eye Hospital, Fukuoka, Japan. DESIGN: Retrospective case study. METHODS: Using an autokeratometer, corneal astigmatism was measured preoperatively, at baseline (the day the surgically induced astigmatism stabilized), and 10 years and 20 years after baseline...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28593459/impact-of-surgery-and-surveillance-in-the-management-of-branch-duct-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-according-to-fukuoka-guidelines-the-bologna-experience
#8
Riccardo Casadei, Claudio Ricci, Giovanni Taffurelli, Carlo Alberto Pacilio, Marina Migliori, Francesco Minni
The objective of the study was to evaluate the Fukuoka guidelines in indicating the proper management for recognising the risk factors of malignancy. Data of patients with branch duct intraductal papillary mucinous neoplasms who underwent pancreatic resection or surveillance according to the Fukuoka risk parameters were collected in a prospective database. The clinical outcome (development of pancreatic cancer, overall and disease-specific survival) and pathological results were evaluated in all patients and in resected cases, respectively...
June 7, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28588393/quantitative-trait-loci-analysis-of-blast-resistance-in-oryza-sativa-l-hokuriku-193
#9
Ichiro Nagaoka, Hideki Sasahara, Hiroaki Tabuchi, Akiko Shigemune, Kei Matsushita, Hideo Maeda, Akitoshi Goto, Shuichi Fukuoka, Tsuyu Ando, Kiyoyuki Miura
To investigate the genetic background responsible for blast resistance in Oryza sativa L. 'Hokuriku 193', QTL analysis was conducted using the F3 lines from the cross [ms-bo] Nekken 2 × Hokuriku 193 that were artificially infected with rice blast fungus (Magnaporthe grisea). QTLs were detected on chromosomes 1, 4, 6 and 12 that correlated with greater blast resistance in the Hokuriku 193-type lines. Notably, the QTL on chromosome 12 had a major effect and localized to the same region where Pi20(t), a broad-spectrum blast resistance gene, is positioned, suggesting strongly that the blast resistance of Hokuriku 193 was controlled by Pi20(t)...
March 2017: Breeding Science
https://www.readbyqxmd.com/read/28584671/hybrid-desmoplastic-follicular-ameloblastoma-of-the-mandible-a-case-report-and-review-of-the-literature
#10
Masayasu Iwase, Airi Fukuoka, Yoko Tanaka, Naoyuki Saida, Eriko Onaka, Sanae Bando, Gen Kondo
Desmoplastic ameloblastoma (DA) is one of the 6 histopathological subtypes of ameloblastoma. Hybrid lesions in which histopathologically conventional ameloblastoma coexists with areas of DA are rare. A 40-year-old male was referred to our hospital complaining of a swelling in the right premolar region of the mandible. A panoramic radiograph showed an area of radiolucency with a well-defined corticated border, whereas computed tomography revealed a unilocular radiolucent lesion and buccal expansion together with cortical perforation...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28583114/the-peripheral-monocyte-count-is-associated-with-the-density-of-tumor-associated-macrophages-in-the-tumor-microenvironment-of-colorectal-cancer-a-retrospective-study
#11
Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shigetomi Nakao, Shinji Matsutani, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Inflammation is widely recognized to play an important role in cancer progression, and the peripheral monocyte count has been reported to correlate with the prognosis in patients with colorectal cancer. This is based on the hypothesis that the peripheral monocyte level and the density of tumor-associated macrophages (TAMs) in the cancer microenvironment correlate with each other. However, the influence of TAMs on the prognosis and the correlation between the peripheral monocyte count and the density of TAMs have not yet been elucidated...
June 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28580699/prognostic-value-of-lymphovascular-invasion-of-the-primary-tumor-in-hypopharyngeal-carcinoma-after-total-laryngopharyngectomy
#12
Yuki Saito, Go Omura, Kazuo Yasuhara, Ryoko Rikitake, Ken Akashi, Osamu Fukuoka, Masafumi Yoshida, Mizuo Ando, Takahiro Asakage, Tatsuya Yamasoba
BACKGROUND: We aimed to determinate the prognostic value of lymphovascular invasion in the specimens resected during total laryngopharyngectomy for hypopharyngeal carcinoma. METHODS: Patients who underwent total laryngopharyngectomy at our institution between 2004 and 2014 were included in this study and retrospectively analyzed. We then discriminated for vascular invasion and lymphatic invasion of the primary tumor in all cases. RESULTS: We reviewed 135 records (120 men and 15 women; age range, 36-84 years)...
June 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28575019/clinicopathologic-significance-of-the-cxcl1-cxcr2-axis-in-the-tumor-microenvironment-of-gastric-carcinoma
#13
Hiroaki Kasashima, Masakazu Yashiro, Hirohisa Nakamae, Go Masuda, Haruhito Kinoshita, Tamami Morisaki, Tatsunari Fukuoka, Tsuyoshi Hasegawa, Takahiko Nakane, Masayuki Hino, Kosei Hirakawa, Masaichi Ohira
PURPOSE: It was reported that the chemokine (C-X-C motif) ligand 1 (CXCL1) from cancer cells stimulated the recruitment of bone marrow-derived mesenchymal cells (BM-MCs) into tumor stroma via chemokine (C-X-C motif) receptor 2 (CXCR2) signaling. We conducted this retrospective study to determine the clinicopathologic significance of the CXCL1-CXCR2 axis in human gastric cancer. METHODS: The correlations between the clinicopathological features of 270 primary gastric carcinomas and CXCL1 in cancer cells and CXCR2 in stromal cells were analyzed in immunohistochemical studies...
2017: PloS One
https://www.readbyqxmd.com/read/28555661/risk-factors-for-severe-dysphagia-in-acute-cervical-spinal-cord-injury
#14
T Hayashi, Y Fujiwara, H Sakai, T Maeda, T Ueta, K Shiba
STUDY DESIGN: A retrospective, consecutive case series. OBJECTIVES: The relationship between dysphagia and acute cervical spinal cord injury (CSCI) has been recently reported; however, the cause and mechanism of dysphagia are still not well understood. No definitive factors have yet been established according to multivariate analysis. The objective is to elucidate the incidence and risk factors of dysphagia in patients with acute CSCI. SETTING: Spinal Injuries Center, Fukuoka, Japan...
May 30, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28551037/a-child-with-acute-transverse-myelitis-requiring-permanent-pacemaker-implantation
#15
Masataka Fukuoka, Ichiro Kuki, Asako Horino, Kiyohiro Kim, Yuka Hattori, Hitomi Tsuji, Megumi Nukui, Shin Okazaki, Hisashi Kawawaki, Yoko Yoshida, Jyunichi Ishikawa, Hiroshi Rinka
We diagnosed a 3-year-old girl with acute transverse myelitis (ATM). She presented with weakness of the limbs and developed urination difficulty and respiratory disturbance. Magnetic resonance imaging revealed a symmetric area of high signal intensity on T2-weighted images involving the lower end of the medulla oblongata to the level of the fourth thoracic vertebra. Anti-aquaporin-4 antibody was negative. She was treated with intravenous methylprednisolone pulse therapy, immunoglobulin therapy, and plasmapheresis; however, her clinical symptoms did not change...
May 24, 2017: Brain & Development
https://www.readbyqxmd.com/read/28549915/isolated-hypoglossal-paralysis-caused-by-ischemic-infarction-in-the-centrum-semiovale
#16
Takuya Fukuoka, Yoshihiko Nakazato, Naotoshi Tamura, Nobuo Araki, Toshimasa Yamamoto
In the present report, we discuss the case of a 66-year-old woman with isolated unilateral hypoglossal paralysis due to cerebral infarction in the centrum semiovale. To date, it has hardly been discussed where the corticolingual tract passes through in the centrum semiovale. Brain magnetic resonance imaging revealed a small ischemic infarction in the contralateral centrum semiovale. We could demonstrate a route of the corticolingual tract.
May 23, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28541554/activation-of-group-2-innate-lymphoid-cells-exacerbates-and-confers-corticosteroid-resistance-to-mouse-nasal-type-2-inflammation
#17
Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Koubun Yasuda, Naruhito Iwasaki, Shoko Akasaki, Shigeharu Fujieda, Tomohiro Yoshimoto
Both Th2 cells and group 2 innate lymphoid cells (ILC2s) contribute to allergic diseases. However, their exact role and relationship in nasal allergic disorders is unclear. In this study, we investigated the cooperation of Th2 cells and ILC2s in a mouse model of nasal allergic disorder. To differentially activate Th2 cells and/or ILC2s in nasal mucosa, mice were intranasally administered ovalbumin (OVA) antigen, papain, an ILC2-activator, or both for 2 weeks. Epithelial thickness and number of eosinophils in the nasal mucosa were evaluated at 24 hours after the final challenge...
May 25, 2017: International Immunology
https://www.readbyqxmd.com/read/28540931/hyperkalemia-in-both-surgically-and-medically-treated-patients-with-primary-aldosteronism
#18
N Wada, Y Shibayama, H Umakoshi, T Ichijo, Y Fujii, K Kamemura, T Kai, R Sakamoto, A Ogo, Y Matsuda, T Fukuoka, M Tsuiki, T Suzuki, M Naruse
Hyperkalemia is an important complication of adrenalectomy for patients with primary aldosteronism (PA). The frequency of hyperkalemia after medication using mineralocorticoid receptor antagonists (MRAs) for PA is unclear. The aim of this study is to investigate the frequency and the risk factors of hyperkalemia after surgery and medication for PA. The data of 376 patients with PA registered in a multicentre-collaborative study in Japan, including surgically treated patients (group A; n=142) and medically treated patients with MRAs (group B; n=234) were studied...
May 25, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28540626/cross-sectional-prevalence-of-pancreatic-cystic-lesions-in-patients-with-acromegaly-a-single-center-experience
#19
Yukiko Odake, Hidenori Fukuoka, Masaaki Yamamoto, Yoshifumi Arisaka, Junya Konishi, Kenichi Yoshida, Ryusaku Matsumoto, Hironori Bando, Kentaro Suda, Hitoshi Nishizawa, Genzo Iguchi, Shozo Yamada, Wataru Ogawa, Yutaka Takahashi
PURPOSE: Acromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported that GNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study...
May 24, 2017: Pituitary
https://www.readbyqxmd.com/read/28530535/hair-regeneration-therapy-using-proteins-secreted-by-adipose-derived-stem-cells
#20
Hirotaro Fukuoka, Keigo Narita, Hirotaka Suga
Adipose-derived stem cells secrete various cytokines that promote hair growth. We have used adipose-derived stem cell-conditioned medium to treat alopecia and reported good results. In this article, we describe our experience of the hair regeneration therapy including characteristics of the commercialized conditioned medium, treatment methods, and future directions. Treatment using adipose-derived stem cell-conditioned medium is highly effective and may represent a new therapy for alopecia.
May 21, 2017: Current Stem Cell Research & Therapy
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