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mesenchymal stem cell therapy

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https://www.readbyqxmd.com/read/29678576/aging-impairs-beige-adipocyte-differentiation-of-mesenchymal-stem-cells-via-the-reduced-expression-of-sirtuin-1
#1
Vuong Cat Khanh, Amin Firman Zulkifli, Chiho Tokunaga, Toshiharu Yamashita, Yuji Hiramatsu, Osamu Ohneda
In the body, different types of adipose tissue perform different functions, with brown and beige adipose tissues playing unique roles in dissipating energy. Throughout life, adipocytes are regenerated from progenitors, and this process is impaired by aging. One of the progenitors of adipocytes are mesenchymal stem cells (MSCs), which have recently become a promising tool for stem cell therapy. However, whether or not aging impairs the brown/beige adipocyte differentiation of adipose tissue-derived MSCs (AT-MSCs) remains unclear...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678523/safety-and-efficacy-of-mesenchymal-stem-cells-for-radiation-induced-xerostomia-a-randomized-placebo-controlled-phase-1-2-trial-mesrix
#2
Christian Grønhøj, David H Jensen, Peter Vester-Glowinski, Siri Beier Jensen, Allan Bardow, Roberto S Oliveri, Lea Munthe Fog, Lena Specht, Carsten Thomsen, Sune Darkner, Michael Jensen, Vera Müller, Katalin Kiss, Tina Agander, Elo Andersen, Anne Fischer-Nielsen, Christian von Buchwald
BACKGROUND: Salivary gland hypofunction and xerostomia are major complications to head and neck radiotherapy. This trial assessed the safety and efficacy of adipose tissue-derived mesenchymal stem cell (ASC) therapy for radiation-induced xerostomia. PATIENT AND METHODS: This randomized, placebo-controlled phase 1/2 trial included 30 patients, randomized in a 1:1 ratio to receive ultrasound-guided transplantation of ASCs or placebo to the submandibular glands. Patients had previously received radiotherapy for a T1-2, N0-2A, human papillomavirus-positive, oropharyngeal squamous cell carcinoma...
March 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29677537/the-rescue-effect-of-mesenchymal-stem-cell-on-sodium-iodate-induced-retinal-pigment-epithelial-cell-death-through-deactivation-of-nf-%C3%AE%C2%BAb-mediated-nlrp3-inflammasome
#3
Xiying Mao, Ting Pan, Han Shen, Huiyu Xi, Songtao Yuan, Qinghuai Liu
Age-related macular degeneration (AMD) is a multifactorial disease resulting in the gradual loss of retinal pigment epithelium (RPE) and the permanent visual damage. Various risk factors, including oxidative stress, form a complex network at the confluence of inflammation. Mesenchymal stem cell (MSC) is a well-studied population of adult stem cell with strong neuroprotective and immunoregulatory properties. Here, we reported the protective effect of MSC on sodium iodate (NaIO3)-triggered RPE degeneration. Sodium iodate (NaIO3)-induced RPE cell death was remarkably reduced when cocultured with MSC...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29675492/endometrial-mesenchymal-stem-stromal-cells-in-mature-and-immature-sheep-an-in-vitro-study
#4
Farnaz Ghobadi, Farhad Rahmanifar, Davood Mehrabani, Amin Tamadon, Mehdi Dianatpour, Shahrokh Zare, Iman Razeghian Jahromi
Background: Endometrial mesenchymal stem stromal cells (EnMSCs) are critical for uterine function, repair, and regeneration. Objective: This study introduced isolation technique of EnMSCs and compared the characteristics of EnMSCs in mature and immature ewes. Materials and Methods: Endometrial tissue samples from the uterus of 10 ewes were collected from the slaughterhouse. Endometrial cells were isolated from tissue using cold incubation and then chopping and treating was performed with collagenase type I...
February 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29675269/translation-of-remote-control-regenerative-technologies-for-bone-repair
#5
Hareklea Markides, Jane S McLaren, Neil D Telling, Noura Alom, E'atelaf A Al-Mutheffer, Richard O C Oreffo, Andrew Zannettino, Brigitte E Scammell, Lisa J White, Alicia J El Haj
The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of in vitro bone tissue engineering strategies and provides an effective means of controlling cell behaviour towards therapeutic outcomes. However, the delivery of mechanical stimuli to exogenous MSC populations, post implantation, poses a significant translational hurdle...
2018: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29674780/-advanced-medicinal-products-medical-therapy-based-on-mesenchymal-stem-cells
#6
Szydlak Renata
No abstract text is available yet for this article.
2018: Farmacja Polska
https://www.readbyqxmd.com/read/29674661/donor-dependent-variation-of-human-umbilical-cord-blood-mesenchymal-stem-cells-in-response-to-hypoxic-preconditioning-and-amelioration-of-limb-ischemia
#7
Insung Kang, Byung-Chul Lee, Soon Won Choi, Jin Young Lee, Jae-Jun Kim, Bo-Eun Kim, Da-Hyun Kim, Seung Eun Lee, Nari Shin, Yoojin Seo, Hyung-Sik Kim, Dong-Ik Kim, Kyung-Sun Kang
With the rapidly growing demand for mesenchymal stem cell (MSC) therapy, numerous strategies using MSCs for different diseases have been studied and reported. Because of their immunosuppressive properties, MSCs are commonly used as an allogeneic treatment. However, for the many donors who could potentially be used, it is important to understand the capacity for therapeutic usage with donor-to-donor heterogeneity. In this study, we aimed to investigate MSCs as a promising therapeutic strategy for critical limb ischemia...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29674627/ciap1-regulates-the-egfr-snai2-axis-in-triple-negative-breast-cancer-cells
#8
Maria Teresa Majorini, Giacomo Manenti, Miguel Mano, Loris De Cecco, Annalisa Conti, Patrizia Pinciroli, Enrico Fontanella, Elda Tagliabue, Claudia Chiodoni, Mario Paolo Colombo, Domenico Delia, Daniele Lecis
Inhibitor of apoptosis (IAP) proteins constitute a family of conserved molecules that regulate both apoptosis and receptor signaling. They are often deregulated in cancer cells and represent potential targets for therapy. In our work, we investigated the effect of IAP inhibition in vivo to identify novel downstream genes expressed in an IAP-dependent manner that could contribute to cancer aggressiveness. To this end, immunocompromised mice engrafted subcutaneously with the triple-negative breast cancer MDA-MB231 cell line were treated with SM83, a Smac mimetic that acts as a pan-IAP inhibitor, and tumor nodules were profiled for gene expression...
April 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29673400/long-noncoding-rna-h19-upregulates-vascular-endothelial-growth-factor-a-to-enhance-mesenchymal-stem-cells-survival-and-angiogenic-capacity-by-inhibiting-mir-199a-5p
#9
Jingying Hou, Lingyun Wang, Quanhua Wu, Guanghui Zheng, Huibao Long, Hao Wu, Changqing Zhou, Tianzhu Guo, Tingting Zhong, Lei Wang, Xuxiang Chen, Tong Wang
BACKGROUND: Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs) transplantation for the treatment of cardiovascular disease is not satisfactory. The low viability and angiogenic capacity of the implanted cells in the local infarct tissues restrict their further application. Evidence shows that long noncoding RNA H19 (lncRNA-H19) mediates cell survival and angiogenesis. Additionally, it is also involved in MSCs biological activities. This study aimed to explore the functional role of lncRNA-H19 in MSCs survival and angiogenic capacity as well as the underlying mechanism...
April 19, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29673394/transplantation-of-adipose-derived-mesenchymal-stem-cells-attenuates-pulmonary-fibrosis-of-silicosis-via-anti-inflammatory-and-anti-apoptosis-effects-in-rats
#10
Shangya Chen, Guanqun Cui, Cheng Peng, Martin F Lavin, Xiaoying Sun, Enguo Zhang, Ye Yang, Yingjun Guan, Zhongjun Du, Hua Shao
BACKGROUND: Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured. Recent advances in stem cell research have made possible the treatment of various diseases including lung fibrosis. The application of stem cell therapy in occupational diseases, in particular the use of adipose-derived mesenchymal stem cells (AD-MSCs) in treatment of silicosis, has not yet been reported. The aim of the study is to explore the intervening effect of silica-induced lung fibrosis in rats...
April 19, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29671652/effects-of-educated-monocytes-with-xenogeneic-mesenchymal-stem-cell-derived-conditioned-medium-in-a-mouse-model-of-chronic-asthma
#11
Hadi Esmaili Gourvarchin Galeh, Seyyed Meysam Abtahi Froushani, Nahideh Afzale Ahangaran, Siamak Naji Hadai
BACKGROUND: This study was conducted to determine the potential of the monocytes educated with rat bone marrow mesenchymal stem cell-derived conditioned medium (MCM) in ameliorating animal model of asthma. METHODS: Chronic asthma was induced in the BALB/c mice using ovalbumin (OVA) sensitization. The monocytes were isolated from blood of mice and supplemented with 50% MCM or negative control media. After 24 h, the cells were designated as "non-educated or educated"...
April 19, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29670878/matrix-metalloproteinase-2-impairs-homing-of-intracoronary-delivered-mesenchymal-stem-cells-in-a-porcine-reperfused-myocardial-infarction-comparison-with-intramyocardial-cell-delivery
#12
Katrin Zlabinger, Dominika Lukovic, Rayyan Hemetsberger, Alfred Gugerell, Johannes Winkler, Ljubica Mandic, Denise Traxler, Andreas Spannbauer, Susanne Wolbank, Gerald Zanoni, Christoph Kaun, Aniko Posa, Andrea Gyenes, Zsolt Petrasi, Örs Petnehazy, Imre Repa, Renate Hofer-Warbinek, Rainer de Martin, Florian Gruber, Silvia Charwat, Kurt Huber, Noemi Pavo, Imre J Pavo, Noemi Nyolczas, Dara L Kraitchman, Mariann Gyöngyösi
Background: Intracoronary (IC) injection of mesenchymal stem cells (MSCs) results in a prompt decrease of absolute myocardial blood flow (AMF) with late and incomplete recovery of myocardial tissue perfusion. Here, we investigated the effect of decreased AMF on oxidative stress marker matrix metalloproteinase-2 (MMP-2) and its influence on the fate and homing and paracrine character of MSCs after IC or intramyocardial cell delivery in a closed-chest reperfused myocardial infarction (MI) model in pigs...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29670281/identification-of-the-tumour-transition-states-occurring-during-emt
#13
Ievgenia Pastushenko, Audrey Brisebarre, Alejandro Sifrim, Marco Fioramonti, Tatiana Revenco, Soufiane Boumahdi, Alexandra Van Keymeulen, Daniel Brown, Virginie Moers, Sophie Lemaire, Sarah De Clercq, Esmeralda Minguijón, Cédric Balsat, Youri Sokolow, Christine Dubois, Florian De Cock, Samuel Scozzaro, Federico Sopena, Angel Lanas, Nicky D'Haene, Isabelle Salmon, Jean-Christophe Marine, Thierry Voet, Panagiota A Sotiropoulou, Cédric Blanpain
In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour stemness, metastasis and resistance to therapy. It has recently been proposed that, rather than being a binary process, EMT occurs through distinct intermediate states. However, there is no direct in vivo evidence for this idea. Here we screen a large panel of cell surface markers in skin and mammary primary tumours, and identify the existence of multiple tumour subpopulations associated with different EMT stages: from epithelial to completely mesenchymal states, passing through intermediate hybrid states...
April 18, 2018: Nature
https://www.readbyqxmd.com/read/29670130/a-novel-s100a8-a9-induced-fingerprint-of-mesenchymal-stem-cells-associated-with-enhanced-wound-healing
#14
Abhijit Basu, Saira Munir, Medanie A Mulaw, Karmveer Singh, Benedikt Herold, Diana Crisan, Anca Sindrilaru, Nicolai Treiber, Meinhard Wlaschek, Markus Huber-Lang, Florian Gebhard, Karin Scharffetter-Kochanek
We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pretreated with the calcium-binding DAMP protein S100A8/A9 into murine full-thickness wounds, we observed a significant acceleration of healing even exceeding that of non-treated MSCs. This correlates with a fundamental reprogramming of the transcriptome in S100A8/A9 treated MSCs as deduced from RNA-seq analysis and its validation...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669248/niches-for-hematopoietic-stem-cells-and-their-progeny
#15
REVIEW
Qiaozhi Wei, Paul S Frenette
Steady-state hematopoietic stem cells' (HSCs) self-renewal and differentiation toward their mature progeny in the adult bone marrow is tightly regulated by cues from the microenvironment. Recent insights into the cellular and molecular constituents have uncovered a high level of complexity. Here, we review emerging evidence showing how HSCs and their progeny are regulated by an interdependent network of mesenchymal stromal cells, nerve fibers, the vasculature, and also other hematopoietic cells. Understanding the interaction mechanisms in these intricate niches will provide great opportunities for HSC-related therapies and immune modulation...
April 17, 2018: Immunity
https://www.readbyqxmd.com/read/29668637/successful-mesenchymal-stem-cell-treatment-of-leg-ulcers-complicated-by-behcet-disease-a-case-report-and-literature-review
#16
Yanhong Li, Zhongming Wang, Yi Zhao, Yubin Luo, Wangdong Xu, Tony N Marion, Yi Liu
RATIONALE: Behçet disease (BD) is a recurrent vasculitis characterized by oral and genital mucous membrane ulcers, uveitis, and skin lesions but only rarely leg ulcers. To our knowledge, no efficacious therapy has been described for BD patients with complicating, destructive leg ulcers. PATIENT CONCERNS: Here, We report the case of a 55-year-old woman with generalized erythema nodosum-like, papulopustular lesions, recurrent oral and genital ulcers accompanied with recurrent leg ulcers and trouble walking...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667344/concise-review-aggressive-colorectal-cancer-role-of-epithelial-cell-adhesion-molecule-in-cancer-stem-cells-and-epithelial-to-mesenchymal-transition
#17
REVIEW
Maximilian Boesch, Gilbert Spizzo, Andreas Seeber
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In spite of various attempts to ameliorate outcome by escalating treatment, significant improvement is lacking particularly in the adjuvant setting. It has been proposed that cancer stem cells (CSCs) and the epithelial-to-mesenchymal transition (EMT) are at least partially responsible for therapy resistance in CRC. The epithelial cell adhesion molecule (EpCAM) was one of the first CSC antigens to be described. Furthermore, an EpCAM-specific antibody (edrecolomab) has the merit of having launched the era of monoclonal antibody treatment in oncology in the 1990s...
April 17, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29667069/the-versatile-role-of-exosomes-in-cancer-progression-diagnostic-and-therapeutic-implications
#18
REVIEW
Vignesh Sundararajan, Fazlul H Sarkar, Thamil Selvee Ramasamy
BACKGROUND: Recent advances in cancer biology have highlighted the relevance of exosomes and nanovesicles as carriers of genetic and biological messages between cancer cells and their immediate and/or distant environments. It has been found that these molecular cues may play significant roles in cancer progression and metastasis. Cancer cells secrete exosomes containing diverse molecules that can be transferred to recipient cells and/or vice versa to induce a plethora of biological processes, including angiogenesis, metastasis formation, therapeutic resistance, epithelial-mesenchymal transition and epigenetic/stemness (re)programming...
April 17, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29665002/three-dimensional-collagenous-niche-and-azacytidine-selectively-promote-time-dependent-cardiomyogenesis-from-human-bone-marrow-derived-msc-spheroids
#19
Jyotsna Joshi, Gautam Mahajan, Chandrasekhar R Kothapalli
Endogenous adult cardiac regenerative machinery is not capable of replacing the lost cells following myocardial infarction, often leading to permanent alterations in structure-function-mechanical properties. Regenerative therapies based on delivering autologous stem cells within an appropriate 3D milieu could meet such demand, by enabling homing and directed differentiation of the transplanted cells into lost specialized cell populations. Since type I collagen is the predominant cardiac tissue matrix protein, we here optimized the 3D niche which could promote time-dependent evolution of cardiomyogenesis from human bone marrow-derived mesenchymal stem cells (BM-MSC)...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29662192/capillary-morphogenesis-gene-2-maintains-gastric-cancer-stem-like-cell-phenotype-by-activating-a-wnt-%C3%AE-catenin-pathway
#20
Chengdong Ji, Lang Yang, Weijing Yi, Dongfang Xiang, Yanxia Wang, Zhihua Zhou, Feng Qian, Yong Ren, Wei Cui, Xia Zhang, Peng Zhang, Ji Ming Wang, Youhong Cui, Xiuwu Bian
A growing body of evidence shows that the development and progression of gastric cancer (GC) is mainly associated to the presence of gastric cancer stem-like cells (GCSLCs). However, it is unclear how GCSLC population is maintained. This study aimed to explore the role of capillary morphogenesis gene 2 (CMG2) in GCSLC maintenance and the relevance to GC progression. We found that CMG2 was highly expressed in GC tissues and the expression levels were associated with the invasion depth and lymph node metastasis of GC, and inversely correlated with the survival of GC patients...
April 17, 2018: Oncogene
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