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https://www.readbyqxmd.com/read/29043560/optimal-timing-of-dopamine-agonist-withdrawal-in-patients-with-hyperprolactinemia-a-systematic-review-and-meta-analysis
#1
Miao Yun Xia, Xiao Hui Lou, Shao Jian Lin, Zhe Bao Wu
PURPOSE: Dopamine agonists (DAs) are recommended as first-line treatment for patients with hyperprolactinemia. Generally, it is accepted that patients with hyperprolactinemia do not need lifelong medication, but the optimal timing for DA withdrawal has not been determined. The aim of this systematic review and meta-analysis is to assess the impact of DA withdrawal on the clinical outcomes of patients with hyperprolactinemia, and to explore possible factors affecting successful DA withdrawal...
October 17, 2017: Endocrine
https://www.readbyqxmd.com/read/29035904/improvement-in-cognitive-abilities-following-cabergoline-treatment-in-patients-with-a-prolactin-secreting-pituitary-adenoma
#2
Itziar Montalvo, Marta Llorens, Laia Caparrós, Montserrat Pamias, Jordi Torralbas, Olga Giménez-Palop, Assumpta Caixàs, Diego J Palao, Javier Labad
Hyperprolactinaemia may affect sexual and reproductive functioning. However, recent studies suggest that increased prolactin levels may also have negative effects on cognition. We aimed to study whether the reduction in prolactin levels by cabergoline in patients with hyperprolactinaemia is followed by an improvement in cognitive tasks. We studied seven patients with hyperprolactinaemia caused by a prolactinoma that had an indication to start treatment with cabergoline. All patients were assessed twice (baseline and 6-12 months after cabergoline treatment) with a cognitive battery...
October 13, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28973192/pituitary-tumor-suppression-by-combination-of-cabergoline-and-chloroquine
#3
Shao Jian Lin, Ze Rui Wu, Lei Cao, Yong Zhang, Zhi Gen Leng, Yu Hang Guo, Han Bing Shang, Wei Guo Zhao, Xun Zhang, Zhe Bao Wu
CONTEXT: The dopamine agonist cabergoline (CAB) has been used widely in treatment of prolactinomas and other types of pituitary adenomas, but its clinical use is hampered by intolerance in some prolactinoma patients and lack of effectiveness in other pituitary tumor types. Chloroquine (CQ) is an old drug widely used in treatment of malaria. Recent studies, including our own, have revealed that CAB and CQ are involved in induction of autophagy and activation of autophagic cell death. OBJECTIVE: We tested whether CAB and CQ can function cooperatively to suppress growth of pituitary adenomas as well as other cancers...
July 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28964519/inhibiting-prolactin-by-cabergoline-accelerates-mammary-gland-remodeling-during-the-early-dry-period-in-dairy-cows
#4
M Boutinaud, N Isaka, E Gandemer, P Lamberton, S Wiart, A I De Prado Taranilla, L M Sordillo, V Lollivier
The inhibition of prolactin release using cabergoline, a dopamine agonist, is an effective strategy to accelerate the changes in mammary secretion composition after drying-off. The objective of this study was to determine how cabergoline may affect mammary tissue remodeling during early involution. Holstein dairy cows were treated with either a single i.m. administration of 5.6 mg of cabergoline (Velactis, Ceva Santé Animale, Libourne, France, n = 7) or placebo (n = 7) at the time of drying-off. Mammary biopsy samples were collected 1 wk before drying-off (d -6), after 30 h of milk accumulation (d 1), and again 8 d following drying-off (d 8) to determine changes in gene expression, lactoferrin content, and cell turnover...
September 27, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28954263/beneficial-effects-of-high-doses-of-cabergoline-in-the-treatment-of-giant-prolactinoma-resistant-to-dopamine-agonists-a-case-report-with-a-21-year-follow-up
#5
Lucas Faria de Castro, Maria de Fátima Magalhães Gonzaga, Luciana Ansaneli Naves, José Luiz Mendonça, Benicio Oton de Lima, Luiz Augusto Casulari
INTRODUCTION: Prolactinomas are pituitary tumors with a very low prevalence in childhood and adolescence compared to adulthood. This condition is preferentially treated with dopamine agonists. Resistance to these drugs is rare. CASE REPORT: We describe the case of a boy diagnosed with macroadenoma at the age of 9 and followed up for 21 years. He did not fully respond to treatment with dopamine agonists. His initial prolactin level was 2,400 ng/mL (in males, normal values are <16...
September 26, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28931779/the-efficacy-of-medical-treatment-in-patients-with-acromegaly-in-clinical-practice
#6
Seo Young Lee, Jung Hee Kim, Ji Hyun Lee, Yong Hwy Kim, Hyang Jin Cha, Sang Wan Kim, Sun Ha Paek, Chan Soo Shin
Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. The CAB (45...
September 20, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28904504/role-of-serpine-gene-polymorphism-in-recurrent-implantation-failure-and-preeclampsia
#7
Nidhi Sharma, Jayashree K Srinivasan, Margeret Harriet Priya, Venkatachalam Sibiya
This is a rare case of serpine gene polymorphism causing thrombophilia and recurrent implantation failure following intrauterine insemination. SERPINE1 gene encodes plasminogen activator inhibitor type 1 and inhibits fibrinolysis, or clot dissolution. The 4G variant results in increased expression of SERPINE1 and consequently higher inhibition of fibrinolysis, thus leading to thrombophilia. The patient had unexplained primary infertility for 9 years. Ovulation induction was done with gonadotropin releasing hormone (GnRH) agonist long protocol...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28885368/successful-management-of-octreotide-insensitive-thyrotropin-secreting-pituitary-adenoma-with-bromocriptine-and-surgery-a-case-report-and-literature-review
#8
REVIEW
Chengxian Yang, Huanwen Wu, Jing Wang, Mingming Hu, Xiaoping Xing, Xinjie Bao, Renzhi Wang
RATIONALE: Case reports concerning the value of dopamine agonists in the treatment of patients with thyrotropin-secreting pituitary adenoma (TSHoma) are limited. Herein, we present a rare case of octreotide-insensitive TSHoma responding to bromocriptine therapy. PATIENT CONCERNS: A 45-year-old Chinese man was admitted to Peking Union Medical College Hospital with marked clinical manifestations of hyperthyroidism. DIAGNOSES: Thyroid function tests demonstrated elevated concentrations of free thyroid hormones in the presence of normal thyrotropin...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28867888/efficacy-of-combined-cabergoline-and-metformin-compared-to-metformin-alone-on-cycle-regularity-in-patients-with-polycystic-ovarian-disease-with-hyperprolactinemia-a-randomized-clinical-trial
#9
Mervat Ali Mohamed Elsersy
PURPOSE: Polycystic ovarian syndrome (PCOS) is a common reproductive disorder. Increasing serum prolactin in these patients could be detected in both follicular and luteal phase of the normal and stimulated cycles. Hyperprolactinemia affects the hypothalamic-pituitary-ovarian axis causing anovulation and abnormal uterine bleeding. In this study, the efficacy of combined cabergoline and metformin therapy was compared to metformin therapy alone in patients with PCOS on the body mass index, androgen profile and menstrual cycle regulation...
October 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28845563/in-this-issue-september-2017-identifying-bloodlines-of-animals-with-mutations%C3%A2-%C3%A2-%C3%A2-sexed-semen-in-dairy-cows%C3%A2-%C3%A2-%C3%A2-conventional-vs-automatic-milking-systems%C3%A2-%C3%A2-%C3%A2-overground-endoscopy-in-thoroughbred-horses%C3%A2-%C3%A2-%C3%A2-honeys-for-wound-healing%C3%A2-%C3%A2-%C3%A2-cabergoline-in-anoestrous
#10
EDITORIAL
https://www.readbyqxmd.com/read/28845559/use-of-cabergoline-for-oestrus-induction-in-multiparous-anoestrous-beagle-bitches
#11
Y Shimatsu
OBJECTIVE: The purpose of this study was to examine the efficacy of daily cabergoline administration on oestrus induction in bitches. METHODS AND RESULTS: Of 20 multiparous Beagle bitches, 15 were not mated with sires in their last oestrus and 5 bitches that had been mated whelped. All bitches were in early or mid-anoestrus and received 5 μg/kg/day cabergoline PO. Oestrus was induced in the mid-anoestrus bitches at a higher rate than in the early anoestrus bitches...
September 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28845230/screening-for-valve-disease-in-patients-with-hyperprolactinaemia-disorders-prescribed-cabergoline-a-service-evaluation-and-literature-review
#12
REVIEW
David Gamble, Rachel Fairley, Roderick Harvey, Colin Farman, Nathan Cantley, Stephen J Leslie
OBJECTIVES: The indication for screening for valvular heart disease in patients taking cabergoline is based on evidence from patients with Parkinson's disease on high-dose medication. However, current patients take much lower doses for indications such as hyperprolactinaemia disorders. Contemporary guidelines for echocardiogram monitoring in patients taking cabergoline are conflicting. This study aimed to review current clinical practice in our area regarding echocardiographic screening and to review the literature examining the evidence of valvular heart disease in patients taking lower dose cabergoline...
July 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28819518/-a-rare-case-of-giant-galactocele-associated-with-prolactinoma
#13
Mariam Tayae, Jihad Jamor
Galactocele is a rare cystic formation, a benign breast lesion, occurring when breast duct is blocked and engorged. It generally affects postpartum women, either breastfeeding or not. Only a few cases have been reported in the literature and they were not related to lactation, as in the case of postmenopausal women or of men; moreover, their relationship to the overproduction of prolactin, a growth factor stimulating mammary epithelial cells, is not very well defined at this time. We here report the unusual case of a 30-year old patient with no personal history of childbirth or abortion...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28812531/prolactinoma-in-a-dog
#14
Cristina Cosio, Elena Sartori, Marcello Garatti, Lorenzo Luccardini, G C M Grinwis, Hans S Kooistra, Federico Fracassi
A 12-year-old male Yorkshire Terrier was presented because of decreased appetite. Physical examination revealed mammary gland swelling and galactorrhea. Contrast-enhanced computed tomographic scanning of the skull indicated an enlarged pituitary gland, compatible with a pituitary tumor. The serum prolactin concentration was markedly elevated. One week after the start of treatment with the dopamine agonist cabergoline, the serum prolactin concentration normalized and the galactorrhea resolved. Cabergoline was administered for approximately 4 months and then discontinued...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28791188/an-intact-dopamine-sensitivity-in-the-brain-a-necessity-to-recover-hyperprolactinemia-and-galactorrhea-in-a-female-hemodialysis-patient
#15
Eva Philipse, Ester Philipse, Theodorus Twickler, Amaryllis Van Craenenbroeck, Marie Madeleine Couttenye, Luc Van Gaal
A female hemodialysis patient with galactorrhea due to hyperprolactinemia was treated with different dialysis modalities to assess the effect on prolactin levels. A single session of both high-flux hemodialysis and hemodiafiltration resulted in decreased prolactin levels (16,6% and 77,2%, resp.). However, baseline prolactin levels measured immediately before the next dialysis session did not change markedly. After cabergoline treatment was started, prolactin levels normalized and galactorrhea disappeared. Thus, dopaminergic inhibition of prolactin secretion might be reduced in patients with end-stage renal disease...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/28774283/effectiveness-of-spinal-cord-stimulation-for-painful-camptocormia-with-pisa-syndrome-in-parkinson-s-disease-a-case-report
#16
Hisanao Akiyama, Saki Nukui, Masashi Akamatu, Yasuhiro Hasegawa, Osamu Nishikido, Soichiro Inoue
BACKGROUND: Spinal cord stimulation (SCS) has recently been reported to be effective for truncal postural abnormalities such as camptocormia and Pisa syndrome in Parkinson's disease. In this case report, we describe a case of a woman with Parkinson's disease in whom SCS was effective for painful camptocormia with Pisa syndrome. CASE PRESENTATION: A 65-year-old woman was admitted to our hospital because of painful camptocormia. She had noticed resting tremor in the left upper limb and aprosody at 48 years of age...
August 3, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28750784/the-clinical-follow-up-of-estradiol-benzoate-priming-during-induction-of-estrus-with-cabergoline-in-dogs
#17
Asghar Mogheiseh, Mohammad Javad Mosavi Ghiri, Esmaeil Bandarian
Induction of estrus is used to improve reproductive efficiency of female dogs. In this study, 11 adult healthy female dogs were selected at anestrus stage. The dogs were assigned to treatment (6 dogs) and control groups (5 dogs). Single dose of estradiol benzoate was injected in treatment group at day 0 (0.01mg/kg, IM). Dogs in both groups received cabergoline (5μg/kg orally) from day 7 to the onset of proestrus. Vaginal cytology and blood samples were taken twice a week during study. Average time to the onset of proestrus was 10...
March 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28750783/effects-of-cabergoline-on-thyroid-hormones-and-semen-quality-of-dog
#18
Asghar Mogheiseh, Negar Vara, Mohammad Ayaseh, Parvin Jalali
In this study, the concentration of prolactin, FT4, and semen quality were investigated in 5 clinically healthy fertile mixed-breed dogs (1-3 years old) treated with cabergoline (5μg/kg) during 9 weeks. Semen analysis was performed for volume, live or dead, concentration, and motility factors every week. The results indicated that cabergoline administration caused a minor but significant reduction of the mean prolactin concentration (P < .05) and did not affect the secretion of FT4 (P > .05). Further, there was not a significant effect of cabergoline on semen quality, statistically...
March 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28721221/pasireotide-successful-treatment-of-a-sparsely-granulated-tumour-in-a-resistant-case-of-acromegaly
#19
W K M G Amarawardena, K D Liyanarachchi, J D C Newell-Price, R J M Ross, D Iacovazzo, M Debono
The granulation pattern of somatotroph adenomas is well known to be associated with differing clinical and biochemical characteristics, and it has been shown that sparsely granulated tumours respond poorly to commonly used somatostatin receptor ligands (SRLs). We report a challenging case of acromegaly with a sparsely granulated tumour resistant to multiple modalities of treatment, ultimately achieving biochemical control with pasireotide. A 26-year-old lady presented with classical features of acromegaly, which was confirmed by an oral glucose tolerance test...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28710189/use-of-cabergoline-for-the-management-of-persistent-cushing-s-disease-in-pregnancy
#20
Kathleen Su-Yen Sek, Doddabele Srinivasa Deepak, Kok Onn Lee
Cushing's disease (CD) is rare during pregnancy and is associated with significant maternal and fetal complications. It is important to control hypercortisolism during pregnancy, either surgically or medically, for a successful maternal and fetal outcome. We report a patient with recurrent CD who was treated with low-dose cabergoline (CAB) for persistent hypercortisolism throughout pregnancy. A 36-year-old woman was diagnosed with CD at the age of 23. She underwent trans-sphenoidal surgery with initial complete remission...
July 14, 2017: BMJ Case Reports
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