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A Oguz, D Tuzun, M Sahin, K Gul
Prolactinomas are the most common pituitary tumors but rarely seen in adolescent males. There is no indication for surgery both in micro- and macro-adenomas unless an urgent treatment is necessary. First line treatment is always medical with dopamine agonists. In this report, we presented a patient with pubertal arrest and giant prolactinoma that disappeared in a short time with cabergoline treatment.
September 2016: Nigerian Journal of Clinical Practice
PaweĊ‚ Zajdel, Marek Bednarski, Jacek Sapa, Gabriel Nowak
Ergotamine, being a representative of naturally occurring ergoline alkaloids, derived from d-lysergic acid, and nicergoline, a d-lumilysergic acid derivative belonging to semi-synthetic ergot-derived alkaloids, display diversified affinity for adrenergic, serotoninergic, and dopamine receptors. Although introduction of triptans marginalized use of ergotamine, nicergoline is used in cerebral metabolic-vascular disorders, and dementia. Additionally, nicergoline exhibits a safety profile comparable to that of placebo, and none of the reviewed studies reported any incidence of fibrosis or ergotism with nicergoline treatment...
April 2015: Pharmacological Reports: PR
Ummi Nadira, Rizna Abdul Cader, Norella C T Kong, Rozita Mohd, Halim A Gafor
BACKGROUND: Malignancies are more common in patients with systemic lupus erythematosus (SLE) than the general population. SLE patients are recognized to have higher prolactin levels. However, there are very few reported cases of SLE with pituitary adenomas. CASE REPORT: We report the second case of a pituitary adenoma in a patient with underlying SLE. A 51 year old lady presented with blurred vision and magnetic resonance imaging of the brain demonstrated a pituitary macroadenoma with mildly elevated serum prolactin levels...
2012: American Journal of Case Reports
Olufemi T Oladapo, Bukola Fawole
BACKGROUND: Various pharmacologic and non-pharmacologic interventions have been used to suppress lactation after childbirth and relieve associated symptoms. Despite the large volume of literature on the subject, there is currently no universal guideline on the most appropriate approach for suppressing lactation in postpartum women. OBJECTIVES: To evaluate the effectiveness and safety of interventions used for suppression of lactation in postpartum women (who have not breastfed or expressed breastmilk) to determine which approach has the greatest comparative benefits with least risk...
2012: Cochrane Database of Systematic Reviews
Elena Biagini, Alessandra Berardini, Maddalena Graziosi, Stefania Rosmini, Chiara Pazzi, Claudio Rapezzi
The role of a gender effect (that means differences in clinical manifestations, access to therapies and response to treatments according to gender) in cardiomyopathies remains a matter of debate. Although recent studies have evaluated the differences in the clinical features and prognosis between the two sexes, many issues remain to be elucidated. At present, the only sex-specific condition that affects females is peripartum cardiomyopathy. Recent evidence suggests a pathogenetic role of a prolactin derivative, and ongoing clinical trials are investigating the possibility of targeted therapies using prolactin secretion inhibitors, such as bromocriptine and carbegoline...
June 2012: Giornale Italiano di Cardiologia
Ofer Arnon, David Mendes, Eyal Winkler, Jeremy Tamir, Arie Orenstein, Joseph Haik
Galactorrhea complicating wound healing following reduction mammaplasty occurs rarely; only isolated cases have been reported in recent years. We report the case of a 25-year-old woman who presented with delayed healing and dehiscence of surgical wounds 3 weeks following vertical scar reduction mammaplasty. During surgical debridement, spontaneous discharge of milk in the wound was noted. Serum prolactin levels were high, and she was treated with carbegoline, a dopamine agonist, which suppressed the prolactin secretion and led to rapid cessation of lactation...
May 2006: Aesthetic Surgery Journal
Adam W Templeton, Kwabena K Pobi, John Turco, Ajay K Nangia
OBJECTIVE: To present a case of prolactinoma presenting as a failed vasectomy reversal. DESIGN: Case report. SETTING: University-affiliated teaching hospital. PATIENT(S): A 46-year-old male with severe oligospermia after bilateral vasovasostomy and his 31-year-old female partner who had normal cycles. INTERVENTION(S): Bromocriptine, carbegoline, and l IVF. MAIN OUTCOME MEASURE(S): Correction of hyperprolactinoma, improved semen analysis, and pregnancy achieved by assisted reproductive technologies...
November 2007: Fertility and Sterility
V Sarapura, W D Schlaff
Hyperprolactinemia is frequently diagnosed in patients with infertility and menstrual cycle irregularities. Control of prolactin secretion is complex and involves inhibition by dopamine and possibly endothelins, as well as stimulation by serotoninergic and opioidergic pathways, gonadotropin-releasing hormone, and possibly galanin. Some patients with hyperprolactinemia have underlying functional disorders, but by using magnetic resonance imaging, a microprolactinoma can be found in most. Prolactin circulates in a low-bioactivity glycosylated and a nonglycosylated form, and an antibody-bound form is found in a few hyperprolactinemic patients who are relatively asymptomatic...
June 1993: Current Opinion in Obstetrics & Gynecology
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