keyword
Keywords degenerative mitral valve insu...

degenerative mitral valve insufficiency

https://read.qxmd.com/read/38352455/decreased-left-atrial-cardiomyocyte-fgf13-expression-increases-vulnerability-to-postoperative-atrial-fibrillation-in-humans
#1
Matthew A Fischer, Adrian Arrieta, Marina Angelini, Elizabeth Soehalim, Douglas J Chapski, Richard J Shemin, Thomas M Vondriska, Riccardo Olcese
Postoperative atrial fibrillation (POAF) is the most common complication after cardiac surgery and a significant cause of increased morbidity and mortality. The development of novel POAF therapeutics has been limited by an insufficient understanding of molecular mechanisms promoting atrial fibrillation. In this observational cohort study, we enrolled 28 patients without a history of atrial fibrillation that underwent mitral valve surgery for degenerative mitral regurgitation and obtained left atrial tissue samples along the standard atriotomy incision in proximity to the right pulmonary veins...
January 31, 2024: bioRxiv
https://read.qxmd.com/read/37688566/the-impact-of-annuloplasty-ring-or-band-implantation-on-post-repair-mitral-valve-hemodynamic-performance
#2
JOURNAL ARTICLE
Anton Tomšič, Elena Sandoval, Maria C Meucci, Takeru Nabeta, Manuel Castella, Anna Muro, Robert J M Klautz, Nina Ajmone Marsan, Daniel Pereda, Meindert Palmen
BACKGROUND: The clinical importance of optimal post-repair mitral valve diastolic performance is increasingly being recognized. The haemodynamic effect of a partial annuloplasty band implantation, in comparison to a full ring, remains insufficiently explored. METHODS: Patients undergoing mitral valve repair for pure degenerative disease between 2011 and 2019 at two experienced heart valve centres were eligible for inclusion. Exclusion criteria were concomitant procedures other than tricuspid valve repair and ablation procedures for atrial fibrillation...
September 9, 2023: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/37456353/transcatheter-mitral-valve-replacement-in-patients-with-mitral-annular-calcification-a-review
#3
REVIEW
Ankit Agrawal, Michael J Reardon, Sachin S Goel
Mitral annular calcification (MAC) is a progressive degenerative calcification of the mitral valve (MV) that is associated with mitral stenosis, regurgitation or both. Patients with MAC are poor candidates for MV surgery because of technical challenges and high peri-operative mortality. Transcatheter MV replacement (TMVR) has emerged as an option for such high surgical risk patients. This has been described with the use of the SAPIEN transcatheter heart valve (valve-in-MAC) and dedicated TMVR devices. Careful anatomic assessment is important to avoid complications of TMVR, such as left ventricular outflow tract obstruction, valve migration, embolization and paravalvular mitral regurgitation...
2023: Heart International
https://read.qxmd.com/read/37354131/escalation-from-impella-5-5-to-ecpella-support-as-a-bridge-to-mitral-valve-surgery-in-a-patient-with-degenerative-mitral-regurgitation
#4
JOURNAL ARTICLE
Vasiliki Gregory, Matan Grunfeld, Arjun Kanwal, Atul D Bali, Stephen Pan, David Spielvogel, Masashi Kai, Suguru Ohira
Severe mitral regurgitation (MR) is an important cause of acute heart failure and significant contributor to morbidity and mortality. Mechanical circulatory support (MCS) devices such as Impella are readily used to hemodynamically stabilize patients with cardiogenic shock (CS) secondary to this valvular pathology. Impella can also be combined with VA-ECMO to an "ECPELLA" configuration if further escalation of hemodynamic support is needed. We report a case of a 57-year-old female who presented with CS secondary to a perforated anterior mitral valve leaflet and non-ischemic cardiomyopathy that did not stabilize with initial choice of Impella 5...
June 24, 2023: Perfusion
https://read.qxmd.com/read/37283912/rapidly-progressive-infective-endocarditis-after-mitraclip-therapy-a-rare-complication-of-transcatheter-edge-to-edge-mitral-valve-repair
#5
Hiroshi Tsunamoto, Hiroyuki Yamamoto, Nobuyuki Takahashi, Tetsuari Onishi, Akiko Masumoto, Hirohisa Murakami, Kunimitsu Kawahara, Hiroya Kawai, Tomofumi Takaya
UNLABELLED: Infective endocarditis (IE) is a rare, life-threatening complication of MitraClip (Abbott, Abbott Park, IL, USA) therapy. We report a case of an 84-year-old male who underwent transcatheter edge-to-edge mitral valve (MV) repair using MitraClip (Abbott, Abbott Park, IL, USA) 4 weeks prior for ventricular functional mitral regurgitation (MR) and returned with unstable hemodynamics and high-grade fever. Transthoracic echocardiography (TTE) on emergency admission showed thickening of the anterior mitral leaflet (AML) without apparent MR deterioration...
June 2023: Journal of Cardiology Cases
https://read.qxmd.com/read/37273862/coaptation-length-as-predictor-of-recurrent-mitral-regurgitation-after-surgical-repair-for-degenerative-mitral-valve-disease-meta-analysis-of-reconstructed-time-to-event-data
#6
JOURNAL ARTICLE
Michel Pompeu Sá, Xander Jacquemyn, Jef Van den Eynde, Ozgun Erten, Tulio Caldonazo, Torsten Doenst, Mateo Marin-Cuartas, Michael A Borger, Marie-Annick Clavel, Philippe Pibarot, Roberto Rodriguez, Basel Ramlawi, Scott Goldman
No abstract text is available yet for this article.
May 2023: Structural heart: the journal of the Heart Team
https://read.qxmd.com/read/37208162/long-term-outcomes-of-concomitant-suture-bicuspidization-technique-to-treat-mild-or-moderate-tricuspid-regurgitation-in-patients-undergoing-mitral-valve-surgery
#7
JOURNAL ARTICLE
Antonio Piperata, Jef Van Den Eynde, Mathieu Pernot, Olivier Busuttil, Martina Avesani, Tomaso Bottio, Stephane Lafitte, Thomas Modine, Louis Labrousse
OBJECTIVES: To investigate the long-term outcomes of concomitant suture bicuspidization to treat mild or moderate tricuspid regurgitation at the time of mitral valve surgery. METHODS: Data from patients who underwent mitral valve surgery for degenerative mitral valve regurgitation with mild or moderate tricuspid regurgitation and annular dilatation between January 2009 and December 2017 were analyzed. The cohort was divided into 2 groups: mitral valve surgery alone and mitral valve surgery with concomitant tricuspid valve repair...
May 19, 2023: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/36943376/left-atrial-function-and-not-volume-predicts-mid-to-late-atrial-fibrillation-after-mitral-valve-repair
#8
JOURNAL ARTICLE
Antonia van Kampen, Yasufumi Nagata, Alex Lin-I Huang, Navyatha Mohan, Jacob P Dal-Bianco, Judy W Hung, Michael A Borger, Robert A Levine, Thoralf M Sundt, Serguei Melnitchouk
OBJECTIVES: Patients undergoing surgical mitral valve repair for degenerative mitral regurgitation are at risk of even late postoperative atrial fibrillation (AF). Left atrial (LA) functionhas been shown superior to LA volume in evaluating risk of AF in diverse cardiac conditions. We therefore investigated the prognostic value of LA function and volume in predicting mid-to-late postoperative AF after mitral valve repair (>30 days postoperatively). METHODS: We retrospectively identified all patients who underwent mitral valve repair for degenerative mitral regurgitation between 2012-2019 at our institution...
March 21, 2023: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/36750353/predictors-of-mitral-valve-haemodynamics-after-mitral-valve-repair-for-degenerative-mitral-regurgitation
#9
JOURNAL ARTICLE
Rawan K Rumman, Subodh Verma, Vincent Chan, David Mazer, Adrian Quan, Makoto Hibino, Benoit De Varennes, Michael W A Chu, David Latter, Hwee Teoh, Bobby Yanagawa, Howard Leong-Poi, Kim A Connelly
OBJECTIVE: Intraoperative predictors of functional mitral valve (MV) stenosis after surgical repair of mitral regurgitation (MR) caused by prolapse remain poorly characterised. This study evaluated the effect of annuloplasty size on postoperative MV haemodynamics during exercise and evaluated predictors of MV hemodynamics. METHODS: 104 patients were randomly assigned to leaflet resection or preservation for surgical repair of MR in the Canadian Mitral Research Alliance CardioLink-2 study...
February 7, 2023: Heart
https://read.qxmd.com/read/36573420/the-mida-q-mortality-risk-score-a-quantitative-prognostic-tool-for-the-mitral-valve-prolapse-spectrum
#10
JOURNAL ARTICLE
Benjamin Essayagh, Giovanni Benfari, Clemence Antoine, Francesco Grigioni, Thierry Le Tourneau, Jean-Christian Roussel, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan, Aniek van Wijngaarden, Christophe Tribouilloy, Dan Rusinaru, Aviram Hochstadt, Yan Topilsky, Prabin Thapa, Hector I Michelena, Maurice Enriquez-Sarano
BACKGROUND: Mitral valve prolapse (MVP) is responsible for a considerable disease burden but is widely heterogeneous. The lack of a comprehensive prognostic instrument covering the entire MVP spectrum, encompassing the quantified consequent degenerative mitral regurgitation (DMR), hinders clinical management and therapeutic trials. METHODS: The new Mitral Regurgitation International Database Quantitative (MIDA-Q) registry enrolled 8187 consecutive patients (ages 63±16 years, 47% women, follow-up 5...
March 7, 2023: Circulation
https://read.qxmd.com/read/36483610/robotic-and-endoscopic-mitral-valve-repair-for-degenerative-disease
#11
JOURNAL ARTICLE
Akhil Rao, Karissa Tauber, Wilson Y Szeto, W Clark Hargrove, Pavan Atluri, Michael Acker, Todd Crawford, Michael E Ibrahim
BACKGROUND: Minimally invasive mitral valve repair has been proven to be a safe alternative to open sternotomy and may be accomplished through classic endoscopic and robotic endoscopic approaches. Outcomes across different minimally invasive techniques have been insufficiently described. We compare early and late clinical outcomes across matched patients undergoing robotic endoscopic and classic endoscopic repair. METHODS: From 2011 to 2020, 786 patients underwent minimally invasive mitral surgery, from which we were able to generate 124 matched patients (62 patients in each cohort)...
November 2022: Annals of Cardiothoracic Surgery
https://read.qxmd.com/read/36168574/surgical-mitral-valve-repair-technique-considerations-based-on-the-available-evidence
#12
REVIEW
Tolga Can, Hristo Kirov, Tulio Caldonazo, Murat Mukharyamov, Gloria Färber, Torsten Doenst
Mitral valve regurgitation is the second most common valve disease in the western world. Surgery is currently the best tool for generating a long-lasting elimination of mitral valve regurgitation. However, the mitral valve apparatus is a complex anatomical and functional structure, and repair results and durability show substantial heterogeneity. This is not only due to differences in the underlying mitral valve regurgitation pathophysiology but also due to differences in repair techniques. Repair philosophies differ substantially from one surgeon to the other, and consensus for the technically best repair strategy has not been reached yet...
April 2022: Türk Göğüs Kalp Damar Cerrahisi Dergisi
https://read.qxmd.com/read/35882521/long-term-outcomes-in-distinct-phenogroups-of-patients-with-primary-mitral-regurgitation-undergoing-valve-surgery
#13
JOURNAL ARTICLE
Soongu Kwak, Seung-Ah Lee, Jaehyun Lim, Seokhun Yang, Hong-Mi Choi, In-Chang Hwang, Sahmin Lee, Yeonyee Elizabeth Yoon, Jun-Bean Park, Hyung-Kwan Kim, Yong-Jin Kim, Jong-Min Song, Goo-Yeong Cho, Kyung-Hwan Kim, Duk-Hyun Kang, Dae-Hee Kim, Seung-Pyo Lee
OBJECTIVES: Patients with mitral regurgitation (MR) may be heterogeneous with different risk profiles. We aimed to identify distinct phenogroups of patients with severe primary MR and investigate their long-term prognosis after mitral valve (MV) surgery. METHODS: The retrospective cohort of patients with severe primary MR undergoing MV surgery (derivation, n=1629; validation, n=692) was analysed. Latent class analysis was used to classify patients into subgroups using 15 variables...
January 27, 2023: Heart
https://read.qxmd.com/read/35717232/severe-mitral-valve-insufficiency-caused-by-standard-surgical-aortic-valve-implantation-and-its-reparation-using-suture-less-prosthesis
#14
JOURNAL ARTICLE
Mahmoud Al-Obeidallah, Kohut Marián, Milan Štengl
BACKGROUND: Aortic valve stenosis is the most frequent cardiac valve pathology in the western world. Surgical aortic valve replacement is the gold standard for the treatment of significant degenerative aortic valve diseases. CASE PRESENTATION: This case report highlights an unexpected abnormal iatrogenic shortening of the aorto-mitral continuity and its deformity, during traditional AVR using sutured stented aortic prosthesis as the first choice, which caused significant mitral valve regurgitation...
June 18, 2022: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/35691867/iberian-experience-with-pascal-transcatheter-edge-to-edge-repair-for-mitral-valve-regurgitation
#15
JOURNAL ARTICLE
Chi-Hion Pedro Li, Rodrigo Estévez-Loureiro, Xavier Freixa, Rui Teles, Ana I Molina-Ramos, Manuel Pan, Luis Nombela-Franco, Bruno Melica, Ignacio J Amat-Santos, Ignacio Cruz-González, Lluís Asmarats, Robert Alarcón, Laura Sanchis, Estefanía Fernández-Peregrina, José Antonio Baz, Xavier Millán, Irene Menduiña, Dabit Arzamendi
INTRODUCTION AND OBJECTIVES: The PASCAL system is a novel device for transcatheter mitral valve repair based on the edge-to-edge concept. The unique features of this device might have a relevant impact on the repair outcomes. There are few data on clinical outcomes in real-life registries. The aim of this study was to report the early Iberian experience (Spain and Portugal) of the PASCAL system. METHODS: Procedural and 30-day outcomes were investigated in consecutive patients with symptomatic severe mitral regurgitation (MR) treated with the PASCAL system at 10 centers...
June 10, 2022: Revista Española de Cardiología
https://read.qxmd.com/read/35464518/a-rare-presentation-of-systolic-anterior-motion-occurring-eight-years-after-mitral-valve-replacement
#16
Olushola O Ogunleye, Hussain Dalal, Khalid Mahmood, Siyamek Neragi-Miandoab, Aarti Campo
Systolic anterior motion (SAM) is the dynamic displacement of mitral valve leaflets anteriorly toward the left ventricular outflow tract (LVOT) during systole. SAM-like physiology has been reported to occur shortly after mitral valve replacement (MVR) surgery; occurrence beyond two years after surgery is very rare. A 55-year-old woman who had bioprosthetic MVR eight years earlier for non-rheumatic mitral stenosis presented to the emergency room with progressive dyspnea and sudden-onset chest pressure. Physical examination noted a grade 3/6 systolic murmur at the cardiac apex, a soft diastolic murmur at the left sternal border, and diffuse expiratory wheezing...
March 2022: Curēus
https://read.qxmd.com/read/35343608/role-of-matrix-metalloproteinases-in-mitral-valve-regurgitation-association-between-the-of-mmp-1-mmp-9-timp-1-and-timp-2-expression-degree-of-mitral-valve-insufficiency-and-pathologic-etiology
#17
JOURNAL ARTICLE
Marc Irqsusi, Azza Labene Mansouri, Anette Ramaswamy, Peter Rexin, Midhat Salman, Saqib Mahmood, Nikolas Mirow, Tamer Ghazi, Rabia Ramzan, Ardawan J Rastan, Sebastian Vogt
BACKGROUND: The pathogenesis of mitral valve insufficiency is not yet fully understood. Several studies stressed the role of matrix metalloproteinases (MMPs) in the emergence of valvular pathologies. The primary objective of the present study is to analyze the role of selected MMPs and their inhibitors in mitral valve insufficiency. PATIENTS AND METHODS: Eighty patients (33 female/47 male, mean age 67 years) underwent cardiopulmonary bypass surgery for mitral valve reconstruction between 2007 and 2015...
March 28, 2022: Journal of Cardiac Surgery
https://read.qxmd.com/read/35128318/aortic-valve-insufficiency-due-to-myxomatous-degeneration-a-case-report-and-literature-review
#18
Basel Abdelazeem, Rachel M Hollander, Tyler M Gresham, Rudin Gjeka, Arvind Kunadi
Myxomatous degeneration is a non-inflammatory degenerative process leading to disruption of the fibrosa layer of the valve with acid mucopolysaccharide accumulation. This type of degeneration commonly affects the mitral valve leading to mitral regurgitation; however, few cases have been reported regarding myxomatous degeneration of the aortic valve leading to acute decompensated heart failure. We report a case of myxomatous degeneration of the aortic valve as an etiology of acute decompensated heart failure to highlight the importance of considering myxomatous degeneration as an underlying etiology of symptomatic aortic insufficiency...
2022: AME Case Reports
https://read.qxmd.com/read/34767705/concomitant-tricuspid-repair-in-patients-with-degenerative-mitral-regurgitation
#19
RANDOMIZED CONTROLLED TRIAL
James S Gammie, Michael W A Chu, Volkmar Falk, Jessica R Overbey, Alan J Moskowitz, Marc Gillinov, Michael J Mack, Pierre Voisine, Markus Krane, Babatunde Yerokun, Michael E Bowdish, Lenard Conradi, Steven F Bolling, Marissa A Miller, Wendy C Taddei-Peters, Neal O Jeffries, Michael K Parides, Richard Weisel, Mariell Jessup, Eric A Rose, John C Mullen, Samantha Raymond, Ellen G Moquete, Karen O'Sullivan, Mary E Marks, Alexander Iribarne, Friedhelm Beyersdorf, Michael A Borger, Arnar Geirsson, Emilia Bagiella, Judy Hung, Annetine C Gelijns, Patrick T O'Gara, Gorav Ailawadi
BACKGROUND: Tricuspid regurgitation is common in patients with severe degenerative mitral regurgitation. However, the evidence base is insufficient to inform a decision about whether to perform tricuspid-valve repair during mitral-valve surgery in patients who have moderate tricuspid regurgitation or less-than-moderate regurgitation with annular dilatation. METHODS: We randomly assigned 401 patients who were undergoing mitral-valve surgery for degenerative mitral regurgitation to receive a procedure with or without tricuspid annuloplasty (TA)...
January 27, 2022: New England Journal of Medicine
https://read.qxmd.com/read/34473777/characterization-of-the-spontaneous-degenerative-mitral-valve-disease-in-fvb-mice
#20
JOURNAL ARTICLE
Estelle Ayme-Dietrich, Sylvia Da Silva, Ghina Alame Bouabout, Alizée Arnoux, Jérôme Guyonnet, Guillaume Becker, Laurent Monassier
BACKGROUND: The development of new non-surgical treatments dedicated to mitral valve degeneration is limited by the absence of relevant spontaneous and rapidly progressing animal experimental models. ANIMALS: We characterized the spontaneous mitral valve degeneration in two inbred FVB mouse strains compared to C57BL/6J and investigated a contribution of the serotonergic system. METHODS: Males and females FVB/NJ and FVB/NRj were compared to the putative C57BL/6J control at 12, 16, 20 and 24 weeks of age...
2021: PloS One
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