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https://www.readbyqxmd.com/read/29665327/adjuvant-radiotherapy-and-chemotherapy-improve-survival-in-patients-with-pancreatic-adenocarcinoma-receiving-surgery-adjuvant-chemotherapy-alone-is-insufficient-in-the-era-of-intensity-modulation-radiation-therapy
#1
Mao-Chih Hsieh, Wei-Wen Chang, Hsin-Hsien Yu, Chang-Yun Lu, Chia-Lun Chang, Jyh-Ming Chow, Shee-Uan Chen, Yunfeng Cheng, Szu-Yuan Wu
In the era of intensity modulation radiation therapy (IMRT), no prospective randomized trial has evaluated the efficacy of adjuvant therapies such as adjuvant concurrent chemoradiotherapy (CCRT), adjuvant sequential chemotherapy and radiotherapy (CT-RT), and adjuvant CT alone in resectable pancreatic adenocarcinoma (PA). Through propensity score matching, we designed a nationwide, population-based, head-to-head cohort study to determine the effects of dissimilar adjuvant treatments on resectable PA. We minimized the confounding of various adjuvant treatment outcomes among the following resectable PA groups of patients from the Taiwan Cancer Registry database: group 1, adjuvant CCRT; group 2, adjuvant sequential CT-RT; and group 3, adjuvant CT alone...
April 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29650419/comparison-of-pathological-complete-response-rates-after-neoadjuvant-short-course-radiotherapy-or-chemoradiation-followed-by-delayed-surgery-in-locally-advanced-rectal-cancer
#2
Sieske Hoendervangers, Alice M Couwenberg, Martijn P W Intven, Wilhelmina M U van Grevenstein, Helena M Verkooijen
INTRODUCTION: Patients with locally advanced rectal cancer (LARC) who are unfit for chemoradiation (CRT), are often offered short-course radiotherapy followed by delayed surgery (SCRT-delay). This entails a lower radiation dose, no chemotherapy and a shorter treatment period. This may lower their chances for complete tumor response and, as such, organ-sparing approaches. The purpose of this study was to compare the pathological complete response (pCR) rates between neoadjuvant CRT and SCRT-delay in patients with LARC in a nationwide database from the Netherlands...
March 23, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29649611/predictors-of-adverse-discharge-disposition-in-adult-spinal-deformity-and-associated-costs
#3
Peter G Passias, Gregory W Poorman, Cole A Bortz, Rabia Qureshi, Bassel G Diebo, Justin C Paul, Samantha R Horn, Frank A Segreto, Alexandra Pyne, Cyrus M Jalai, Virginie Lafage, Shay Bess, Frank J Schwab, Hamid Hassanzadeh
BACKGROUND CONTEXT: With advances in the understanding of adult spinal deformity (ASD), more complex osteotomy and fusion techniques are being implemented with increasing frequency. Patients undergoing ASD corrections infrequently require extended acute care, longer inpatient stays, and are discharged to supervised care. Given the necessity of value-based health care, identification of clinical indicators for adverse discharge disposition in ASD surgeries is paramount. PURPOSE: On nationwide and surgeon-created databases, identify predictors of adverse discharge disposition after ASD surgeries and view corresponding differences in charges...
April 9, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29628978/basic-findings-regarding-breast-cancer-in-korea-in-2015-data-from-a-breast-cancer-registry
#4
REVIEW
Sang Yull Kang, Yoo Seok Kim, Zisun Kim, Hyun-Yul Kim, Se Kyung Lee, Kyu-Won Jung, Hyun Jo Youn
The Korean Breast Cancer Society (KBCS) has established a nationwide breast cancer database using an online registration program in 1996. The present study aimed to analyze the basic findings and trends of breast cancer in Korea in 2015 using the data provided by the Korea Central Cancer Registry and the KBCS. In 2015, a total of 22,550 patients were newly diagnosed with breast cancer, of which 3,331 were carcinoma in situ cases and 19,219 were invasive cancer cases. The incidence rate of breast cancer in Korea has steadily increased since the nationwide database was established, and the crude rate and age-standardized rate including that of carcinoma in situ , were 88...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29620642/in-hospital-mortality-and-morbidity-of-pediatric-scoliosis-surgery-in-japan-analysis-using-a-national-inpatient-database
#5
Yuki Taniguchi, Takeshi Oichi, Junichi Ohya, Hirotaka Chikuda, Yasushi Oshima, Yoshitaka Matsubayashi, Hiroki Matsui, Kiyohide Fushimi, Sakae Tanaka, Hideo Yasunaga
Several previous reports have elucidated the mortality and incidence of complications after pediatric scoliosis surgery using nationwide databases. However, all of these studies were conducted in North America. Hence, this study aimed to identify the incidence and risk factors for in-hospital mortality and morbidity in pediatric scoliosis surgery, utilizing the Diagnosis Procedure Combination database, a national inpatient database in Japan.We retrospectively extracted data for patients aged less than 19 years who were admitted between 01 June 2010 and 31 March 2013 and underwent scoliosis surgery with fusion...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29614656/exposure-to-general-anesthesia-and-risk-of-dementia-a-nationwide-population-based-cohort-study
#6
Clara Tammy Kim, Woojae Myung, Matthew Lewis, Hyewon Lee, Satbyul Estella Kim, Kyungsang Lee, Chunsoo Lee, Junbae Choi, Ho Kim, Bernard J Carroll, Doh Kwan Kim
BACKGROUND: There is a growing concern that general anesthesia could increase the risk of dementia. However, the relationship between anesthesia and subsequent dementia is still undetermined. OBJECTIVE: To determine whether the risk of dementia increases after exposure to general anesthesia. METHODS: A population-based prospective cohort study analyzing the Korean National Health Insurance Service-National Sample Cohort database was conducted of all persons aged over 50 years (n = 219,423) from 1 January 2003 and 31 December 2013...
March 29, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29609841/the-safety-and-risk-factors-of-revision-adenoidectomy-in-children-and-adolescents-a-nationwide-retrospective-population-based-cohort-study
#7
Dai-Lou Lin, Chuan-Song Wu, Chao-Hsiun Tang, Ting-Yu Kuo, Tzong-Yang Tu
OBJECTIVE: To investigate the safety of adenoidectomy and risk factors of re-adenoidectomy, and intend to provide evidence-based information to clinicians for further consideration. METHODS AND MATERIALS: This study was based on data obtained from Taiwan's National Health Insurance Research Database from the period 2002-2011. We utilized that data from the hospitalization group and collected information regarding those individuals who accepted adenoidectomy with or without tonsillectomy and post-adenoidectomy bleeding...
March 30, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29608531/-pathways-to-academic-leadership-in-plastic-surgery-a-nationwide-survey-of-program-directors-division-chiefs-and-department-chairs-of-plastic-surgery
#8
Jordan E Fishman, John Henry Y Pang, Joseph E Losee, J Peter Rubin, Vu T Nguyen
BACKGROUND: While plastic surgeons and plastic surgery residents aspire to leadership in academic plastic surgery, there is no well-established pathway. METHODS: Plastic surgery residencies and program directors(PDs) were obtained from the AMA's FREIDA database. The division chief or department chair (academic head) of every academic plastic surgery program was identified. One internet-based survey was distributed to academic heads, another to PDs. RESULTS: 90 academic heads were identified, 35 of whom also serve as PD...
March 21, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29607559/neck-hematoma-after-major-head-and-neck-surgery-risk-factors-costs-and-resource-utilization
#9
Shivani Shah-Becker, Erin K Greenleaf, Melissa M Boltz, Christopher S Hollenbeak, Neerav Goyal
BACKGROUND: Postoperative cervical hematoma after major head and neck surgery is a feared complication. However, risk factors for developing this complication and attributable costs are not well-established. METHODS: The Nationwide Inpatient Sample database was utilized compare patients with and without postoperative cervical hematoma. Logistic regression was used to analyze risk factors for hematoma formation and 30-day mortality. Total inpatient length of stay (LOS) and costs were fit to generalized linear models...
April 1, 2018: Head & Neck
https://www.readbyqxmd.com/read/29606641/is-transcatheter-aortic-valve-replacement-better-than-surgical-aortic-valve-replacement-in-patients-with-chronic-obstructive-pulmonary-disease-a-nationwide-inpatient-sample-analysis
#10
Tomo Ando, Oluwole Adegbala, Emmanuel Akintoye, Said Ashraf, Mohit Pahuja, Alexandros Briasoulis, Hisato Takagi, Cindy L Grines, Luis Afonso, Theodore Schreiber
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients are at increased risk of respiratory related complications after cardiac surgery. It is unclear whether transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) results in favorable outcomes among COPD patients. METHODS AND RESULTS: Patients were identified from the Nationwide Inpatient Sample database from 2011 to 2014. Patients with age ≥60, COPD, and either went transarterial TAVR or SAVR were included in the analysis...
April 1, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29606044/impact-of-preoperative-endovascular-embolization-on-immediate-meningioma-resection-outcomes
#11
Michael G Brandel, Robert C Rennert, Arvin R Wali, David R Santiago-Dieppa, Jeffrey A Steinberg, Christian Lopez Ramos, Peter Abraham, J Scott Pannell, Alexander A Khalessi
OBJECTIVE Preoperative embolization of meningiomas can facilitate their resection when they are difficult to remove. The optimal use and timing of such a procedure remains controversial given the risk of embolization-linked morbidity in select clinical settings. In this work, the authors used a large national database to study the impact of immediate preoperative embolization on the immediate outcomes of meningioma resection. METHODS Meningioma patients who had undergone elective resection were identified in the National (Nationwide) Inpatient Sample (NIS) for the period 2002-2014...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29602550/minimally-invasive-repair-of-pectus-excavatum-analysis-of-the-nsqip-database-and-the-use-of-thoracoscopy
#12
Oswald Tetteh, Daniel S Rhee, Emily Boss, Samuel M Alaish, Alejandro V Garcia
BACKGROUND: The minimally invasive repair of pectus excavatum (MIRPE) has been widely accepted and has become a viable alternative to the open Ravitch technique. MIRPE has evolved over time with some advocating that a safe repair can be accomplished without direct visualization utilizing thoracoscopy. The MIRPE with and without a thoracoscopic approach has not been previously analyzed from a nationwide database to determine differences in safety and short-term outcomes. METHODS: The American College of Surgeons National Surgical Quality Improvement Program-Pediatric (NSQIP-P) 2012-2015 database was used in identifying patients that had MIRPE using Current Procedural Terminology (CPT) codes and ICD-9CM/ICD-10CM postoperative diagnosis codes...
March 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29596692/the-three-peaks-in-age-distribution-of-females-with-pneumothorax-a-nationwide-database-study-in-japan
#13
Noriko Hiyama, Yusuke Sasabuchi, Taisuke Jo, Tetsuya Hirata, Yutaka Osuga, Jun Nakajima, Hideo Yasunaga
OBJECTIVES: Women are the minority among patients with spontaneous pneumothorax, but catamenial pneumothorax (CP) is unique to them. We aimed to clarify the clinical characteristics of female patients with spontaneous pneumothorax using a nationwide database. METHODS: Medical records from the Japanese Diagnosis Procedure Combination database for inpatients with pneumothorax between July 2010 and March 2016 were retrospectively reviewed. Age, underlying diseases, body mass index, smoking status, laterality, number of hospitalizations and treatments were studied...
March 27, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29596101/intravenous-acetaminophen-does-not-reduce-inpatient-opioid-prescription-or-opioid-related-adverse-events-among-patients-undergoing-spine-surgery
#14
Eva E Mörwald, Jashvant Poeran, Nicole Zubizarreta, Crispiana Cozowicz, Madhu Mazumdar, Stavros G Memtsoudis
BACKGROUND: Having entered the US market relatively recently, the perioperative role of intravenous acetaminophen (ivAPAP) remains to be established for several surgeries. Using national data, we therefore assessed current utilization and whether it reduces inpatient opioid prescription and opioid-related side effects in a procedure with relatively high opioid utilization. METHODS: Patients undergoing a lumbar/lumbosacral spinal fusion (n = 117,269; 2011-2014) were retrospectively identified in a nationwide database and categorized by the amount and timing of ivAPAP administration (1 or >1 dose on postoperative day [POD] 0, 1, or 1+)...
March 27, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29594911/analyzing-the-impact-of-compliance-with-national-guidelines-for-pancreatic-cancer-care-using-the-national-cancer-database
#15
Kathryn Jaap, Marcus Fluck, Marie Hunsinger, Jeffrey Wild, Tania Arora, Mohsen Shabahang, Joseph Blansfield
IMPORTANCE: Management of pancreatic cancer is complex, requiring coordination of multiple providers. National Comprehensive Cancer Network guidelines, developed for standardization and quality improvement, recommend a multimodal approach. OBJECTIVE: This study analyzed national rates of compliance with National Comprehensive Cancer Network recommendations, assessed factors affecting compliance, and evaluated whether compliance with evidence-based guidelines improved overall survival...
March 28, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29590304/long-term-thromboembolic-risk-in-patients-with-postoperative-atrial-fibrillation-after-coronary-artery-bypass-graft-surgery-and-patients-with-nonvalvular-atrial-fibrillation
#16
Jawad H Butt, Ying Xian, Eric D Peterson, Peter Skov Olsen, Rasmus Rørth, Anna Gundlund, Jonas B Olesen, Gunnar H Gislason, Christian Torp-Pedersen, Lars Køber, Emil L Fosbøl
Importance: New-onset postoperative atrial fibrillation (POAF) is a common complication of coronary artery bypass graft (CABG) surgery. However, the long-term risk of thromboembolism in patients who develop POAF after CABG surgery remains unknown. In addition, information on stroke prophylaxis in this setting is lacking. Objective: To examine stroke prophylaxis and the long-term risk of thromboembolism in patients with new-onset POAF after first-time isolated CABG surgery compared with patients with nonsurgical, nonvalvular atrial fibrillation (NVAF)...
March 28, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29584554/national-trends-in-vestibular-schwannoma-surgery-influence-of-patient-characteristics-on-outcomes
#17
Jonathan L Hatch, Michael J Bauschard, Shaun A Nguyen, Paul R Lambert, Ted A Meyer, Theodore R McRackan
Objective To characterize current vestibular schwannoma (VS) surgery outcomes with a nationwide database and identify factors associated with increased complications and prolonged hospital course. Study Design Retrospective review utilizing the University HealthSystem Consortium national inpatient database. Setting US academic health centers. Subjects and Methods Data from patients undergoing VS surgery were analyzed over a 3-year time span (October 2012 to September 2015). Surgical outcomes, such as length of stay (LOS), complications, and mortality, were analyzed on the basis of race, sex, age, and comorbidities during the 30-day postoperative period...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29567515/in-hospital-complication-rate-following-microendoscopic-versus-open-lumbar-laminectomy-a-propensity-score-matched-analysis
#18
Takeshi Oichi, Yasushi Oshima, Hirotaka Chikuda, Junichi Ohya, Hiroki Matsui, Kiyohide Fushimi, Sakae Tanaka, Hideo Yasunaga
BACKGROUND CONTEXT: The incidence of postoperative complications after microendoscopic laminectomy (MEL) has not been compared with that of open laminectomy in a large study, so it is not clear whether MEL is a safer procedure. PURPOSE: To compare postoperative morbidity and mortality following lumbar laminectomy between patients treated with MEL and open laminectomy. STUDY DESIGN: Retrospective cohort study with propensity score-matched analysis...
March 19, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29554443/hospitalization-outcomes-of-cleft-lip-repair-in-neonates-across-the-united-states
#19
Min Kyeong Lee, Stephen L-K Yen, Veerasathpurush Allareddy
OBJECTIVE: Cleft lip repair surgeries in neonates have shown to be effective and safe, resulting in less scarring and excellent aesthetic outcomes. However, existing studies are based on single-center experiences with limited numbers of patients and surgeons. Complication rates and hospital outcomes of neonatal lip repair have not yet been established at the national level. The objective of this study was to examine the association between age at cleft lip repair and hospital outcomes...
April 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29544411/verification-of-data-accuracy-in-japan-congenital-cardiovascular-surgery-database-including-its-postprocedural-complication-reports
#20
Arata Takahashi, Hiraku Kumamaru, Ai Tomotaki, Goki Matsumura, Eriko Fukuchi, Yasutaka Hirata, Arata Murakami, Hideki Hashimoto, Minoru Ono, Hiroaki Miyata
BACKGROUND: Japan Congenital Cardiovascluar Surgical Database (JCCVSD) is a nationwide registry whose data are used for health quality assessment and clinical research in Japan. We evaluated the completeness of case registration and the accuracy of recorded data components including postprocedural mortality and complications in the database via on-site data adjudication. METHODS: We validated the records from JCCVSD 2010 to 2012 containing congenital cardiovascular surgery data performed in 111 facilities throughout Japan...
March 2018: World Journal for Pediatric & Congenital Heart Surgery
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