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https://www.readbyqxmd.com/read/29351668/evaluation-of-the-rapid-carbapenem-inactivation-method-rcim-a-phenotypic-screening-test-for-carbapenemase-producing-enterobacteriaceae
#1
Madalina-Maria Muntean, Andrei-Alexandru Muntean, Lauraine Gauthier, Elodie Creton, Garance Cotellon, Mircea Ioan Popa, Rémy A Bonnin, Thierry Naas
Objectives: Fast and accurate diagnostic tests to identify carbapenemase-producing Enterobacteriaceae (CPE) are mandatory for proper antimicrobial therapy and implementing infection control measures. Here, we have developed a rapid Carbapenem Inactivation Method (rCIM) for CPE detection. Methods: The rCIM consists of the incubation of a potential carbapenemase producer with meropenem discs and use of the resulting supernatant to challenge a susceptible indicator strain...
January 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29351659/smoking-status-and-survival-among-a-national-cohort-of-lung-and-colorectal-cancer-patients
#2
Sandra J Japuntich, Pallavi Kumar, Jane Pendergast, Grelda Yazmin Juarez Caballero, Jennifer Malin, Robert Wallace, Elizabeth Chrischilles, Nancy L Keating, Elyse R Park
Introduction: The purpose of this study was to explore the association of smoking status and clinically relevant duration of smoking cessation with long-term survival after lung cancer (LC) or colorectal cancer (CRC) diagnosis. We compared survival of patients with LC and CRC who were never-smokers, long-term, medium-term, and short-term quitters, and current smokers around diagnosis. Methods: We studied 5,575 patients in Cancer Care Outcomes Research and Surveillance (CanCORS), a national, prospective observational cohort study, who provided smoking status information approximately 5 months after LC or CRC diagnosis...
January 17, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29351655/establishing-diagnostic-reference-levels-for-cardiac-computed-tomography-angiography-in-saudi-arabia
#3
Ali B Alhailiy, Peter L Kench, Mark F McEntee, Patrick C Brennan, Elaine A Ryan
Cardiac computed tomography angiography (CCTA) is a commonly used diagnostic imaging tool for cardiovascular disease. Despite constant improvements to imaging technologies, the radiation dose to patients remains a concern when using this procedure. Diagnostic reference levels (DRLs) are used as a trigger to identify and alert individual facilities that are using high doses during CT. This study aims to assess patient radiation dose and establish new national DRLs (NDRL) associated with CCTA in Saudi clinical practices...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29351625/physical-activity-weight-and-functional-limitations-in-elderly-spanish-people-the-national-health-survey-2009-2014
#4
Pedro A Latorre-Román, José A Laredo-Aguilera, Felipe García-Pinillos, Víctor M Soto-Hermoso, Juan M Carmona-Torres
Background: The purpose of this study was to analyze physical activity (PA), functional limitations, weight status, self-perceived health status and disease or chronic health problems in older people aged 65 and over using the European Health Survey in Spain (EHSS) conducted one in 2009 and one in 2014. Methods: This study included 12,546 older people, 6026 [2330 men and 3696 women; age (Mean, SD) =75.61 ± 7.11 years old] in 2009 and 6520 [2624 men and 3896 women; age (Mean, SD) =75...
January 16, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29351607/sector-wide-or-disease-specific-implications-of-trends-in-development-assistance-for-health-for-the-sdg-era
#5
Anne L Buffardi
The record of the Millennium Development Goals broadly reflects the trade-offs of disease-specific financing: substantial progress in particular areas, facilitated by time-bound targets that are easy to measure and communicate, which shifted attention and resources away from other areas, masked inequalities and exacerbated fragmentation. In many ways, the Sustainable Development Goals reflect a profound shift towards a more holistic, system-wide approach. To inform responses to this shift, this article builds upon existing work on aggregate trends in donor financing, bringing together what have largely been disparate analyses of sector-wide and disease-specific financing approaches...
January 16, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29351596/freedom-solo%C3%A2-versus-trifecta%C3%A2-bioprostheses-clinical-and-haemodynamic-evaluation-after-propensity-score-matching
#6
Rui J Cerqueira, Renata Raimundo, Soraia Moreira, Francisca A Saraiva, Marta Andrade, Elson Salgueiro, Jorge Almeida, Mário Jorge Amorim, Paulo Pinho, André P Lourenço, Adelino Leite-Moreira
OBJECTIVES: The goal of this study was to compare the stentless Freedom Solo® (FS) and the stented Trifecta® (TF) aortic bioprostheses with regard to haemodynamic profile, left ventricular mass regression and early and late postoperative outcomes and survival. METHODS: A longitudinal cohort study of consecutive patients undergoing aortic valve replacement (2009-16) with either the FS or TF at 1 centre was performed. Local databases and national records were queried...
January 16, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29351572/differential-susceptibility-in-ambient-particle-related-first-ever-stroke-onset-risk-findings-from-a-national-case-crossover-study
#7
Tianjia Guan, Tao Xue, Yuanli Liu, Yixuan Zheng, Siyuan Fan, Kebin He, Qiang Zhang
Different populations may respond differently to ambient fine particulate (PM2.5) exposure; however, less is known about the distribution of susceptible individuals among the entire population. We conducted a time-stratified case-crossover design to assess associations between stroke risk and PM2.5. During 2013-2015, 1,356 first-ever stroke onset events were derived from a large representative sample, the China National Stroke Screening Survey (CNSSS) database; daily PM2.5 averages with a spatial resolution of 0...
January 17, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29351505/helping-mediating-and-gaining-recognition-the-everyday-identity-work-of-romanian-health-social-workers
#8
Alexandra Ciocănel, Florin Lazăr, Shari Munch, Cara Harmon, Georgiana-Cristina Rentea, Daniela Gaba, Anca Mihai
Health social work is a field with challenges, opportunities, and ways of professing social work that may vary between different national contexts. In this article, we look at how Romanian health social workers construct their professional identity through their everyday identity work. Drawing on a qualitative study based on interviews with 21 health social workers working in various organizational contexts, we analyze what health social workers say they do and how this shapes their self-conception as professionals...
January 19, 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29351403/project-on-the-good-physician-further-evidence-for-the-validity-of-a-moral-intuitionist-model-of-virtuous-caring
#9
G Michael Leffel, Ross A Oakes Mueller, Sandra A Ham, Kyle E Karches, Farr A Curlin, John D Yoon
THEORY: In the Project on the Good Physician, the authors propose a moral intuitionist model of virtuous caring that places the virtues of Mindfulness, Empathic Compassion, and Generosity at the heart of medical character education. HYPOTHESES: Hypothesis 1a: The virtues of Mindfulness, Empathic Compassion, and Generosity will be positively associated with one another (convergent validity). Hypothesis 1b: The virtues of Mindfulness and Empathic Compassion will explain variance in the action-related virtue of Generosity beyond that predicted by Big Five personality traits alone (discriminant validity)...
January 19, 2018: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/29351363/carers-experiences-of-home-enteral-feeding-a-survey-exploring-medicines-administration-challenges-and-strategies
#10
D Alsaeed, D Furniss, A Blandford, F Smith, M Orlu
WHAT IS KNOWN AND OBJECTIVES: The use of enteral tube feeding at home is becoming more widespread, with patients ranging in age and diseases. Dysphagia and swallowing difficulties can compromise nutritional intake and the administration of oral medications, affecting therapeutic outcomes negatively. Carers' experiences of medicines administration and medicines optimization have not been explored fully. The objectives of this study were to identify issues carers experience in medicines administration; the strategies they have developed to cope; and suggestions to improve the medicines administration process...
January 19, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29351349/survey-research-with-a-random-digit-dial-national-mobile-phone-sample-in-ghana-methods-and-sample-quality
#11
Kelly L'Engle, Eunice Sefa, Edward Akolgo Adimazoya, Emmanuel Yartey, Rachel Lenzi, Cindy Tarpo, Nii Lante Heward-Mills, Katherine Lew, Yvonne Ampeh
INTRODUCTION: Generating a nationally representative sample in low and middle income countries typically requires resource-intensive household level sampling with door-to-door data collection. High mobile phone penetration rates in developing countries provide new opportunities for alternative sampling and data collection methods, but there is limited information about response rates and sample biases in coverage and nonresponse using these methods. We utilized data from an interactive voice response, random-digit dial, national mobile phone survey in Ghana to calculate standardized response rates and assess representativeness of the obtained sample...
2018: PloS One
https://www.readbyqxmd.com/read/29351338/stockouts-of-hiv-commodities-in-public-health-facilities-in-kinshasa-barriers-to-end-hiv
#12
Tinne Gils, Claire Bossard, Kristien Verdonck, Philip Owiti, Ilse Casteels, Maria Mashako, Gilles Van Cutsem, Tom Ellman
Stockouts of HIV commodities increase the risk of treatment interruption, antiretroviral resistance, treatment failure, morbidity and mortality. The study objective was to assess the magnitude and duration of stockouts of HIV medicines and diagnostic tests in public facilities in Kinshasa, Democratic Republic of the Congo. This was a cross-sectional survey involving visits to facilities and warehouses in April and May 2015. All zonal warehouses, all public facilities with more than 200 patients on antiretroviral treatment (ART) (high-burden facilities) and a purposive sample of facilities with 200 or fewer patients (low-burden facilities) in Kinshasa were selected...
2018: PloS One
https://www.readbyqxmd.com/read/29351327/a-novel-risk-classification-system-for-30-day-mortality-in-children-undergoing-surgery
#13
Oguz Akbilgic, Max R Langham, Arianne I Walter, Tamekia L Jones, Eunice Y Huang, Robert L Davis
A simple, objective and accurate way of grouping children undergoing surgery into clinically relevant risk groups is needed. The purpose of this study, is to develop and validate a preoperative risk classification system for postsurgical 30-day mortality for children undergoing a wide variety of operations. The National Surgical Quality Improvement Project-Pediatric participant use file data for calendar years 2012-2014 was analyzed to determine preoperative variables most associated with death within 30 days of operation (D30)...
2018: PloS One
https://www.readbyqxmd.com/read/29351303/automated-inverse-optimization-facilitates-lower-doses-to-normal-tissue-in-pancreatic-stereotactic-body-radiotherapy
#14
Ivaylo B Mihaylov, Eric A Mellon, Raphael Yechieli, Lorraine Portelance
PURPOSE: Inverse planning is trial-and-error iterative process. This work introduces a fully automated inverse optimization approach, where the treatment plan is closely tailored to the unique patient anatomy. The auto-optimization is applied to pancreatic stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: The automation is based on stepwise reduction of dose-volume histograms (DVHs). Five uniformly spaced points, from 1% to 70% of the organ at risk (OAR) volumes, are used...
2018: PloS One
https://www.readbyqxmd.com/read/29351283/decreased-mir-17-in-glioma-cells-increased-cell-viability-and-migration-by-increasing-the-expression-of-cyclin-d1-p-akt-and-akt
#15
Guangwei Sun, Guozhong SiMa, Chunhui Wu, Yongzhong Fan, Yong Tan, Zhong Wang, Gang Cheng, Jie Li
BACKGROUND: The activating mutations of micro RNA (miR)-17 have been revealed in tumors such as human non-Hodgkin's lymphoma and T cell leukemia. However, it is unclear about the role of miR-17 in glioma cells. The current study aimed to investigate effects of miR-17 mimics or inhibitor on the viability and migration of rat glioma C6 cells, and explore possible mechanisms. METHODS: The expression of miR-17 in rat glioma C6 cells and normal brain tissue was detected by quantitative PCR...
2018: PloS One
https://www.readbyqxmd.com/read/29351257/modifications-in-the-consumption-of-energy-sugar-and-saturated-fat-among-the-mexican-adult-population-simulation-of-the-effect-when-replacing-processed-foods-that-comply-with-a-front-of-package-labeling-system
#16
Rosario Mendoza, Lizbeth Tolentino-Mayo, Lucia Hernández-Barrera, Claudia Nieto, Eric A Monterrubio-Flores, Simón Barquera
A Mexican Committee of Nutrition Experts (MCNE) from the National Institute of Public Health (INSP), free from conflict of interest, established food content standards to place the front-of-package (FOP) logo on foods that meet these nutrition criteria. The objectives were to simulate the effect on nutrient intake in the Mexican adult population (20-59 years old) after replacing commonly consumed processed foods with those that meet the FOP nutrition-labeling criteria. Twenty-four hour dietary recalls were collected from the 2012 Mexican National Health and Nutrition Survey (n = 2164 adults)...
January 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29351249/utilizing-dietary-micronutrient-ratios-in-nutritional-research-may-be-more-informative-than-focusing-on-single-nutrients
#17
Owen J Kelly, Jennifer C Gilman, Jasminka Z Ilich
The 2015 US dietary guidelines advise the importance of good dietary patterns for health, which includes all nutrients. Micronutrients are rarely, if ever, consumed separately, they are not tissue specific in their actions and at the molecular level they are multitaskers. Metabolism functions within a seemingly random cellular milieu however ratios are important, for example, the ratio of adenosine triphosphate to adenosine monophosphate, or oxidized to reduced glutathione. Health status is determined by simple ratios, such as the waist hip ratio, or ratio of fat mass to lean mass...
January 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29351244/school-contextual-features-of-social-disorder-and-mental-health-complaints-a-multilevel-analysis-of-swedish-sixth-grade-students
#18
Bitte Modin, Stephanie Plenty, Sara B Låftman, Malin Bergström, Marie Berlin, Per A Gustafsson, Anders Hjern
This study addressed school-contextual features of social disorder in relation to sixth-grade students' experiences of bullying victimization and mental health complaints. It investigated, firstly, whether the school's concentrations of behavioural problems were associated with individual students' likelihood of being bullied, and secondly, whether the school's concentrations of behavioural problems and bullying victimization predicted students' emotional and psychosomatic health complaints. The data were derived from the Swedish National Survey of Mental Health among Children and Young People, carried out among sixth-grade students (approximately 12-13 years old) in Sweden in 2009...
January 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29351207/diabetic-retinopathy-screening-a-systematic-review-on-patients-non-attendance
#19
REVIEW
Rahima Muhammad Kashim, Paul Newton, Omorogieva Ojo
Diabetic Retinopathy is a microvascular complication of diabetes, that can go undetected and unnoticed until irreversible damage and even blindness has occurred. Effective screening for diabetic retinopathy has been proven to reduce the risk of sight loss. The National Health Service (NHS) which provides healthcare for all UK citizens, implemented systematic retinal screening for diabetic retinopathy in England in 2003, with the aim of identifying and treating all patients with sight threatening retinopathy...
January 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29351193/restricted-social-engagement-among-adults-living-with-chronic-conditions
#20
Kayla P Meek, Caroline D Bergeron, Samuel D Towne, SangNam Ahn, Marcia G Ory, Matthew Lee Smith
Background: Social engagement is key to health and quality of life. Little is known about social engagement patterns of middle-aged and older adults who live with one or more chronic illnesses. This study investigated social engagement restrictions among middle-aged and older adults with chronic conditions and factors associated with these restrictions. Methods: Cross-sectional representative data from the National Council on Aging Chronic Care Survey were examined for relationships between social engagement restrictions and chronic conditions, health status, support, quality of life implications, self-care barriers, caregiving, and demographics...
January 19, 2018: International Journal of Environmental Research and Public Health
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