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Awakening

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https://www.readbyqxmd.com/read/29329340/cognitive-control-moderates-parenting-stress-effects-on-children-s-diurnal-cortisol
#1
Laurel Raffington, Florian Schmiedek, Christine Heim, Yee Lee Shing
This study investigated associations between parenting stress in parents and self-reported stress in children with children's diurnal cortisol secretion and whether these associations are moderated by known stress-regulating capacities, namely child cognitive control. Salivary cortisol concentrations were assessed from awakening to evening on two weekend days from 53 6-to-7-year-old children. Children completed a cognitive control task and a self-report stress questionnaire with an experimenter, while parents completed a parenting stress inventory...
2018: PloS One
https://www.readbyqxmd.com/read/29325842/use-of-dexmedetomidine-in-cardiothoracic-and-vascular-anesthesia
#2
REVIEW
Lucía Gallego-Ligorit, Marc Vives, Jorge Vallés-Torres, T Alberto Sanjuán-Villarreal, Azucena Pajares, Mario Iglesias
Dexmedetomidine is a highly selective α2-adrenergic agonist with analgesic and sedative properties. In the United States, the Food and Drug Administration approved the use of the drug for short-lasting sedation (24 h) in intensive care units (ICUs) in patients undergoing mechanical ventilation and endotracheal intubation. In October 2008, the Food and Drug Administration extended use of the drug for the sedation of nonintubated patients before and during surgical and nonsurgical procedures. In the European Union, the European Medicine Agency approved the use of dexmedetomidine in September 2011 with a single recognized indication: ICU adult patients requiring mild sedation and awakening in response to verbal stimulus...
December 2, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29317806/profile-of-sugammadex-for-reversal-of-neuromuscular-blockade-in-the-elderly-current-perspectives
#3
REVIEW
Michele Carron, Francesco Bertoncello, Giovanna Ieppariello
The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of perioperative morbidity and mortality. Complications related to postoperative residual neuromuscular blockade, such as muscle weakness, airway obstruction, hypoxemia, atelectasis, pneumonia, and acute respiratory failure, are more frequent in older than in younger patients...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29317768/ultrafast-syn-eruptive-degassing-and-ascent-trigger-high-energy-basic-eruptions
#4
Marisa Giuffrida, Marco Viccaro, Luisa Ottolini
Lithium gradients in plagioclase are capable of recording extremely short-lived processes associated with gas loss from magmas prior to extrusion at the surface. We present SIMS profiles of the 7Li/30Si ion ratio in plagioclase crystals from products of the paroxysmal sequence that occurred in the period 2011-2013 at Mt. Etna (Italy) in an attempt to constrain the final ascent and degassing processes leading to these powerful eruptions involving basic magma. The observed Li concentrations reflect cycles of Li addition to the melt through gas flushing, and a syn-eruptive stage of magma degassing driven by decompression that finally produce significant Li depletion from the melt...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317179/-adaptation-and-study-of-the-measurement-properties-of-a-sleep-questionnaire-for-infants-and-pre-school-children
#5
Pia Cassanello, Ana Díez-Izquierdo, Nuria Gorina, Nuria Matilla-Santander, Jose M Martínez-Sanchez, Albert Balaguer
INTRODUCTION: Although sleep disturbances in infants and toddlers are common, there is no suitable validated tool in Spanish to evaluate sleep disorders. The Brief Infant Sleep Questionnaire (BISQ) is a well-established multidimensional questionnaire widely used internationally. OBJECTIVES: To adapt the BISQ questionnaire to Spanish and analyse its reliability and validity. To explore its feasibility, both in the clinical context, and in epidemiological research...
January 6, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29310828/-sedation-using-dexmedetomidine-and-remifentanil-with-local-anesthesia-for-intraoperative-speech-monitoring-a-case-report
#6
Leonardo Riedi de Andrade, Yara Marcondes Machado Castiglia
BACKGROUND AND OBJECTIVE: Some surgical procedures such as laryngoplasty require patients to remain conscious during the intraoperative phase in order to enable speech monitoring. Dexmedetomidine and remifentanil were used in this study, since they promote appropriate patient collaboration with facilitated awakening, and are rapidly eliminated. CASE REPORT: The patient complained of dysphonia, which had resulted from unilateral vocal fold paralysis after previous thyroidectomy...
January 5, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29309685/long-range-alpha-beta-and-short-range-gamma-eeg-synchronization-distinguishes-phasic-and-tonic-rem-periods
#7
Péter Simor, Ferenc Gombos, Borbála Blaskovich, Róbert Bódizs
Rapid Eye Movement (REM) sleep is characterized by the alternation of two markedly different microstates, phasic and tonic REM. These periods differ in awakening and arousal thresholds, sensory processing, and spontaneous cortical oscillations. Previous studies indicate that whereas in phasic REM, cortical activity is independent of the external environment, attentional functions and sensory processing are partially maintained during tonic periods. Large-scale synchronization of oscillatory activity, especially in the alpha and beta frequency ranges can accurately distinguish different states of vigilance and cognitive processes of enhanced alertness and attention...
December 23, 2017: Sleep
https://www.readbyqxmd.com/read/29308828/propofol-for-the-promotion-of-sleep-in-adults-in-the-intensive-care-unit
#8
REVIEW
Sharon R Lewis, Oliver J Schofield-Robinson, Phil Alderson, Andrew F Smith
BACKGROUND: People in the intensive care unit (ICU) experience sleep deprivation caused by environmental disruption, such as high noise levels and 24-hour lighting, as well as increased patient care activities and invasive monitoring as part of their care. Sleep deprivation affects physical and psychological health, and people perceive the quality of their sleep to be poor whilst in the ICU. Propofol is an anaesthetic agent which can be used in the ICU to maintain patient sedation and some studies suggest it may be a suitable agent to replicate normal sleep...
January 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29308315/blockade-of-pd-1-effectively-inhibits-in-vivo-malignant-transformation-of-oral-mucosa
#9
Yichen Chen, Qiusheng Li, Xinye Li, Da Ma, Juan Fang, Liqun Luo, Xiangqi Liu, Xi Wang, Vivian Wai Yan Lui, Juan Xia, Bin Cheng, Zhi Wang
Curbing PD-1 immunosuppressive signaling represents an effective immune awakening or immune-reactivation approach for tumor eradication for many cancers. Yet, the potential involvement of this critical PD-1 immunosuppressive signaling in de novo malignant transformation of epithelial cells to pre-cancerous or cancerous lesions is largely unknown. In this study, we demonstrate that PD-1 signaling is critically involved in de novo malignant transformation of oral mucosa upon carcinogen exposure in vivo. Our findings revealed that 4NQO-treated mice had almost double the numbers of PD-1-positive CD4+ cells and PD-1-positive CD8+ cells in peripheral blood lymphocytes as well as elevated PD-1 expression in tumor infiltrating lymphocytes (when compared to that of control-treated mice), strongly supportive of a general immune-suppression induced by carcinogen challenges in vivo...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29306774/the-cortisol-awakening-response-predicts-response-inhibition-in-the-afternoon-of-the-same-day
#10
Xia Shi, Xiaofang Sun, Zhuxi Yao, Yiran Yuan, Jianhui Wu, Angela Clow
The cortisol awakening response (CAR) is the rapid increase of cortisol levels 30-45 min after awakening in the morning. Numerous studies have indicated the relationship between the CAR and cognition. However, little is known about daily variation in the CAR and cognitive function in healthy adults. The aim of the present study was to investigate whether the CAR predicted the response inhibition function on the same day in both behaviour and the dynamic time course of brain processing. The saliva samples of 47 healthy men were collected at three time points: immediately on awakening, 30 min and 45 min post-awakening in the morning...
December 21, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29306691/sleep-behavior-and-depression-findings-from-the-china-kadoorie-biobank-of-0-5-million-chinese-adults
#11
Xiaoyan Sun, Bang Zheng, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhenwang Fu, Hong Guo, Peng Liang, Zhengming Chen, Junshi Chen, Canqing Yu, Liming Li
BACKGROUND: Mixed results have shown the association between sleep behavior and depression, but evidence relating the joint effect of sleep duration and sleep disturbances is limited, especially in Chinese population. METHODS: A total of 512,891 adults aged 30-79 years from China Kadoorie Biobank (CKB) were included. Depression was defined by Composite International Diagnostic Inventory-short form (CIDI-SF). Sleep duration and sleep disturbances, including difficulty initiating and maintaining sleep (DIMS), early morning awakening (EMA), daytime dysfunction (DDF) and any sleep disturbances (ASD), were obtained by a self-reported questionnaire...
December 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29304108/a-four-state-markov-model-of-sleep-wakefulness-dynamics-along-light-dark-cycle-in-mice
#12
Leonel Perez-Atencio, Nicolas Garcia-Aracil, Eduardo Fernandez, Luis C Barrio, Juan A Barios
Behavioral states alternate between wakefulness (wk), rapid eye movement (rem) and non-rem (nrem) sleep at time scale of hours i.e., light and dark cycle rhythms and from several tens of minutes to seconds (i.e., brief awakenings during sleep). Using statistical analysis of bout duration, Markov chains of sleep-wk dynamics and quantitative EEG analysis, we evaluated the influence of light/dark (ld) changes on brain function along the sleep-wk cycle. Bout duration (bd) histograms and Kaplan-Meier (km) survival curves of wk showed a bimodal statistical distribution, suggesting that two types of wk do exist: brief-wk (wkb) and long-wk (wkl)...
2018: PloS One
https://www.readbyqxmd.com/read/29302618/time-restricted-feeding-improves-circadian-dysfunction-as-well-as-motor-symptoms-in-the-q175-mouse-model-of-huntington-s-disease
#13
Huei-Bin Wang, Dawn H Loh, Daniel S Whittaker, Tamara Cutler, David Howland, Christopher S Colwell
Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction. Disturbances in sleep/wake cycles are common among HD patients with reports of delayed sleep onset, frequent bedtime awakenings, and fatigue during the day. The heterozygous Q175 mouse model of HD has been shown to phenocopy many HD core symptoms including circadian dysfunctions. Because circadian dysfunction manifests early in the disease in both patients and mouse models, we sought to determine if early intervention that improve circadian rhythmicity can benefit HD and delay disease progression...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29301922/budesonide-formoterol-maintenance-and-reliever-therapy-in-adolescent-patients-with-asthma
#14
Carin Jorup, Dan Lythgoe, Hans Bisgaard
Asthma control is often suboptimal in adolescents, but few studies have evaluated asthma treatments in this population.This post hoc analysis assessed the efficacy and safety of budesonide/formoterol (BUD/FORM) maintenance and reliever therapy (MART) for treatment of persistent asthma in adolescent (age 12-17 years) subgroups within six randomised, double-blind trials. The primary end-point was time to first severe exacerbation. Secondary end-points included number of severe exacerbations, asthma-related symptoms, night-time awakenings, morning peak expiratory flow, forced expiratory volume in 1 s, as-needed medication use and five-item asthma control questionnaire scores...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29299434/the-effect-of-hydro-alcoholic-of-phoenix-dactylifera-extract-on-sleep-and-eeg-in-rat
#15
Sahar Rahimi, Hojjatollah Alaei, Parham Reisi, Behzad Zolfaghari, Zahra Siahmard, Aliasghar Pourshanazari
Objective: Hard envelope of date palm pollen is used as a sedative and calmative compounds in Iranian traditional medicine. We tried to study the effects of Phoenix dactylifera (Tarooneh) extract on sleep time and Brian waves. Materials and Methods: Rats were divided into control and test groups in sleep experiment. Control groups included intact group (without any injection), negative control group (saline) and positive control group (midazolam 0.1 mg/kg). Test groups received three doses of Tarooneh extract (62...
November 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29295971/special-k-with-no-license-to-kill-accidental-ketamine-overdose-on-induction-of-general-anesthesia
#16
Lindsay L Warner, Nathan Smischney
BACKGROUND Ketamine is used as an induction and sedation agent in emergency departments and operating rooms throughout the country. Despite its widespread clinical use, there are few cases of significant morbidity and mortality attributed to ketamine overdose in the clinical setting. CASE REPORT The anesthesia provider in the room was an oral maxillofacial surgeon who inadvertently took out a more highly concentrated bottle of ketamine that is typically used for pediatric patients. The patient received 950 mg (100 mg/ml concentration) of intravenous ketamine instead of the intended 95 mg (10 mg/ml concentration)...
January 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29289660/early-life-stress-and-cortisol-a-meta-analysis
#17
REVIEW
Nia Fogelman, Turhan Canli
Given the high prevalence of early life stress (ELS) and the potential physiological dysregulation such experiences can lead to, this meta-analysis tested the relationship between ELS and cortisol. Search terms related to ELS and cortisol were entered in to PsycINFO and PubMed. Effect sizes were extracted for four outcomes variables: cortisol awakening response (CAR), baseline cortisol (cortisol at one time point), non-stressed cortisol over time (cortisol captured at two or more time points), and cortisol reactivity to an acute stressor...
December 28, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29288732/blood-derivatives-awaken-in-regenerative-medicine-strategies-to-modulate-wound-healing
#18
Bárbara B Mendes, Manuel Gómez-Florit, Pedro S Babo, Rui L Reis, Rui M A Domingues, Manuela E Gomes
Blood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awaken as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms...
December 27, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29283242/correction-to-global-awakening-of-cryptic-biosynthetic-gene-clusters-in-burkholderia-thailandensis
#19
Ashish Gupta, Renesh Bedre, Sudarshan Singh Thapa, Afsana Sabrin, Guannan Wang, Maheshi Dassanayake, Anne Grove
No abstract text is available yet for this article.
December 28, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29282768/effects-of-pain-treatment-on-sleep-in-nursing-home-patients-with-dementia-and-depression-a-multicenter-placebo-controlled-randomized-clinical-trial
#20
Kjersti Marie Blytt, Bjørn Bjorvatn, Bettina Husebo, Elisabeth Flo
OBJECTIVE: To investigate the effects of pain treatment on sleep in nursing home (NH) patients with dementia and depression. METHODS: A multicenter, 2-armed, double-blinded, placebo-controlled, randomized clinical trial conducted between August 2014 and September 2016. One hundred six long-term patients from 47 NHs in Norway with dementia and depression according to the Mini-Mental State Examination and the Cornell Scale for Depression in Dementia were included...
December 28, 2017: International Journal of Geriatric Psychiatry
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