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Awakening

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https://www.readbyqxmd.com/read/28619111/two-minute-disconnection-technique-with-a-double-lumen-tube-to-speed-the-collapse-of-the-non-ventilated-lung-for-one-lung-ventilation-in-thoracoscopic-surgery
#1
Qiongzhen Li, Xiaofeng Zhang, Jingxiang Wu, Meiying Xu
BACKGROUND: Thoracic surgery requires the effective collapse of the non-ventilated lung. In the majority of cases, we accomplished, accelerated lung collapse using a double-lumen tube (DLT). We hypothesized that using the two-minute disconnection technique with a DLT would improve lung collapse during subsequent one-lung ventilation. METHODS: Fifty patients undergoing thoracoscopic surgery with physical classification I or II according to the American Society of Anesthesiologists were randomly divided into two groups for respiratory management of one-lung ventilation (OLV)...
June 15, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28619090/truffle-renaissance-in-poland-history-present-and-prospects
#2
REVIEW
Aleksandra Rosa-Gruszecka, Dorota Hilszczańska, Wojciech Gil, Bogusław Kosel
The use of truffles in Poland has a long tradition, yet due to some historical aspects, this knowledge was lost. Currently, truffles and truffle orchards are again receiving attention, and thanks to, e.g., historical data, they have solid foundations to be established. Publications relating to truffles between 1661 and 2017 were searched for in international and national databases, such as the database of PhD theses, Google Scholar, and catalogues of the National Library of Poland, the Jagiellonian Digital Library, the University Library of J...
June 15, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28608136/early-impairment-of-intracranial-conduction-time-predicts-mortality-in-deeply-sedated-critically-ill-patients-a-prospective-observational-pilot-study
#3
Eric Azabou, Benjamin Rohaut, Nicholas Heming, Eric Magalhaes, Régine Morizot-Koutlidis, Stanislas Kandelman, Jeremy Allary, Guy Moneger, Andrea Polito, Virginie Maxime, Djillali Annane, Frederic Lofaso, Fabrice Chrétien, Jean Mantz, Raphael Porcher, Tarek Sharshar
BACKGROUND: Somatosensory (SSEP) and brainstem auditory (BAEP) evoked potentials are neurophysiological tools which, respectively, explore the intracranial conduction time (ICCT) and the intrapontine conduction time (IPCT). The prognostic values of prolonged cerebral conduction times in deeply sedated patients have never been assessed. Sedated patients are at risk of developing new neurological complications, undetected. In this prospective observational bi-center pilot study, we investigated whether early impairment of SSEP's ICCT and/or BAEP's IPCT could predict in-ICU mortality or altered mental status (AMS), in deeply sedated critically ill patients...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28604115/a-randomized-controlled-trial-comparing-a-xyloglucan-based-nasal-spray-with-saline-in-adults-with-symptoms-of-rhinosinusitis
#4
Alessandro Allegrini, Daniele Pavone, Fulvio Carluccio
BACKGROUND: This study assessed the efficacy, safety and tolerability of a xyloglucan-based nasal spray in the treatment of symptoms of rhinosinusitis. METHODOLOGY: In this randomized, double-blind study, 40 patients with itching, nasal congestion or continuous sneezing and a Total Nasal Symptom Score (TNSS) of ≥8 were randomized to 2 weeks' treatment with a xyloglucan-based nasal spray ('xyloglucan') or a physiological saline nasal spray ('saline'). Assessments included the TNSS, rhinosinusitis severity index, nocturnal awakenings, use of rescue medication, safety and tolerability...
June 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28603433/evaluation-of-effectiveness-and-safety-of-a-herbal-compound-in-primary-insomnia-symptoms-and-sleep-disturbances-not-related-to-medical-or-psychiatric-causes
#5
Giancarlo Palmieri, Paola Contaldi, Giuseppe Fogliame
BACKGROUND AND PURPOSE: Sleep disturbances and related daytime activities impairment are common diseases nowadays. General practitioners are often the first health care professional asked to alleviate sleep disturbances and primary insomnia symptoms. Beyond a wide class of hypnotic drugs, botanicals can represent an alternative treatment for those kinds of symptoms. The scope of the present study is to evaluate safety and effectiveness of a herbal compound composed of valerian, hop, and jujube (Vagonotte(®)) on primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28601752/daily-positive-events-and-diurnal-cortisol-rhythms-examination-of-between-person-differences-and-within-person-variation
#6
Nancy L Sin, Anthony D Ong, Robert S Stawski, David M Almeida
Growing evidence from field studies has linked daily stressors to dysregulated patterns of diurnal cortisol. Less is known about whether naturally-occurring positive events in everyday life are associated with diurnal cortisol. The objectives of this study were to evaluate daily positive events as predictors of between-person differences and within-person (day-to-day) variations in diurnal cortisol parameters, in addition to daily positive events as buffers against the associations between daily stressors and cortisol...
June 3, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28599586/how-children-with-cerebral-palsy-master-bimanual-activities-from-a-parental-perspective
#7
Git Lidman, Kate Himmelmann, Gunilla Gosman-Hedström, Marie Peny-Dahlstrand
BACKGROUND: During childhood, children learn the daily life activities they want and need to do. Children with unilateral spastic cerebral palsy often have difficulties performing activities requiring two hands. AIM: To describe parental reasoning on how children with unilateral spastic cerebral palsy learn to master the performance of bimanual activities in everyday life. MATERIAL AND METHODS: Sixteen parents participated in focus groups, a qualitative research approach with its own methodological criteria and research methods...
June 9, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28599531/physiological-effects-of-railway-vibration-and-noise-on-sleep
#8
Michael G Smith, Ilona Croy, Mikael Ögren, Oscar Hammar, Eva Lindberg, Kerstin Persson Waye
This paper evaluates the relative contribution of vibration and noise from railway on physiological sleep outcomes. Vibration from railway freight often accompanies airborne noise, yet is almost totally absent in the existing literature. In an experimental investigation, 23 participants, each sleeping for six nights in the laboratory, were exposed to 36 simulated railway freight pass-bys per night with vibration alone (aWd,max = 0.0204 ms(-2)), noise alone (LAF,max = 49.8 dB), or both vibration and noise simultaneously...
May 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28593904/on-the-data-stirring-role-of-the-dentate-gyrus-of-the-hippocampus
#9
REVIEW
Charles R Legéndy
Understanding hippocampal (HC) function, as it is presently known, includes exploring the HC role in episodic memory storage. As pointed out by Teyler and DiScenna in the 1980s, the apparatus needed for recalling a stored episode, and awakening all its components in a coordinated manner, by necessity includes a triggering device able to reach each of the mental entities that must be awakened. In the context of neuronal networks, the triggering device in question takes the form of a large cell assembly, a separate one made for every new episode stored...
April 7, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28589964/hpa-axis-genes-and-their-interaction-with-childhood-maltreatment-are-related-to-cortisol-levels-and-stress-related-phenotypes
#10
Lotte Gerritsen, Yuri Milaneschi, Christiaan Vinkers, Bert van Hemert, Laura van Velzen, Lianne Schmaal, Brenda Wjh Penninx
Stress responses are controlled by the hypothalamus pituitary adrenal (HPA)-axis and maladaptive stress responses are associated with the onset and maintenance of stress-related disorders such as major depressive disorder (MDD). Genes that play a role in the HPA-axis regulation may likely contribute to the relation between relevant neurobiological substrates and stress-related disorders. Therefore, we performed gene-wide analyses for 30 a-priori literature-based genes involved in HPA-axis regulation in 2014 subjects (34% male; mean age: 42...
June 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28587997/long-term-follow-up-of-two-siblings-with-adult-onset-neuronal-ceroid-lipofuscinosis-kufs-type-a
#11
Çiğdem Özkara, Ayşegül Gündüz, Tülin Coşkun, Bengi Gül Alpaslan, Burcu Zeydan, Şakir Delil, Mikko Muona, Anna-Elina Lehesjoki, Meral E Kızıltan
Reports on the clinical presentation of adult-onset neuronal ceroid lipofuscinoses (NCL) are scarce compared to infantile- and childhood-onset forms. Here, we aimed to present detailed temporal evolution of clinical and electrophysiological features of two siblings with adult-onset NCL and homozygous mutation in the CLN6 gene. We retrospectively analysed medical records and electrophysiological data in order to delineate evolution of clinical and electrophysiological findings. Electrophysiological studies included routine EEG and video-EEG, as well as polymyographic analysis of myoclonus and brainstem reflex studies...
June 6, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28584913/effects-of-different-doses-of-triazolam-in-the-middle-of-the-night-insomnia-a-double-blind-randomized-parallel-group-study
#12
Luigi Ferini Strambi, Sara Marelli, Marco Zucconi, Andrea Galbiati, Giovanni Biggio
It has been reported that insomnia characterized by difficulty returning to sleep following a nocturnal awakening, otherwise defined as the middle-of-the-night (MOTN) insomnia, is a common form of insomnia in adults with growing prevalence by increasing age. The aim of this study is to evaluate the efficacy and safety of different dosages of triazolam in insomnia patients when taken after a MOTN awakening with difficulty returning to sleep. In this double-blind, randomized, parallel group study, 24 patients (mean age 41...
June 5, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28584696/redefining-acute-relapses-in-multiple-sclerosis-implications-for-phase-3-clinical-trials-and-treatment-algorithms
#13
EDITORIAL
Jagannadha Avasarala
Relapses in multiple sclerosis are defined as periods of clinical worsening and radiological progression. Magnetic resonance imaging data, however, are not always supportive of "clinical worsening," and clinical symptoms of worsening may not always be present in cases of acute relapse. In the pharmaceutical domain, this discordance between "clinical worsening" and "radiological progression" has never been fully elucidated, and no Phase 3 clinical study has addressed this conundrum. Thus, the true number of acute relapse cases enrolled in Phase 3 clinical studies remains unclear...
March 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/28583511/blood-count-values-and-ratios-for-predicting-sleep-apnea-in-obese-children
#14
Ibrahim Erdim, Omer Erdur, Fatih Oghan, Fatih Mete, Mustafa Celik
OBJECTIVES: To detect whether the mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are contributing factors in the diagnosis and severity of sleep apnea in obese children. INTRODUCTION: Obesity is a public health problem, and its prevalence increases daily. Although PSG is the gold standard test in the investigation of sleep apnea, the application of this test requires equipment, personnel, time, and cost. There is no simple laboratory test for diagnosing and determining the severity of sleep apnea...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28583396/a-novel-endpoint-for-exacerbations-in-asthma-to-accelerate-clinical-development-a-post-hoc-analysis-of-randomised-controlled-trials
#15
Anne L Fuhlbrigge, Thomas Bengtsson, Stefan Peterson, Alexandra Jauhiainen, Göran Eriksson, Carla A Da Silva, Anthony Johnson, Tariq Sethi, Nicholas Locantore, Ruth Tal-Singer, Malin Fagerås
BACKGROUND: Occurrence of severe asthma exacerbations are the cornerstone of the evaluation of asthma management, but severe asthma exacerbations are rare events. Therefore, trials that assess drug efficacy on exacerbations are done late in clinical development programmes. We aimed to establish an endpoint capturing clinically relevant deteriorations (diary events) that, when combined with severe exacerbations, create a composite outcome (CompEx). CompEx needs to strongly mirror results seen with the severe exacerbation-validated outcome, to allow the design of clinical trials of shorter duration and that include fewer patients than trials assessing severe exacerbations...
June 2, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28580858/suboptimal-palliative-sedation-in-primary-care-an-exploration
#16
Peter Pype, Inge Teuwen, Fien Mertens, Marij Sercu, An De Sutter
OBJECTIVES: Palliative sedation is a therapeutic option to control refractory symptoms in terminal palliative patients. This study aims at describing the occurrence and characteristics of suboptimal palliative sedations in primary care and at exploring the way general practitioners (GPs) experience suboptimal palliative sedation in their practice. METHODS: We conducted a mixed methods study with a quantitative prospective survey in primary care and qualitative semi-structured interviews with GPs...
June 5, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28575467/arousability-and-fall-risk-during-forced-awakenings-from-nocturnal-sleep-among-healthy-males-following-administration-of-zolpidem-10-mg-and-doxepin-6-mg-a-randomized-placebo-controlled-four-way-crossover-trial
#17
Christopher L Drake, Heith Durrence, Philip Cheng, Thomas Roth, Vivek Pillai, Edward L Peterson, Meeta Singh, Kieulinh Michelle Tran
Study Objectives: To examine and compare the arousability threshold and fall risk upon awakening of doxepin (6 mg) versus zolpidem (10 mg). Methods: A total of 52 healthy adult males were included in a double-blind, placebo-controlled, 4-way crossover study. The experimental procedure included four nights with polysomnography in the lab (zolpidem, doxepin, and their respective placebo conditions). Arousability was measured using an auditory awakening threshold delivered at the peak-plasma concentration for the active hypnotics and at matched times for the respective placebo conditions...
June 1, 2017: Sleep
https://www.readbyqxmd.com/read/28574579/the-effect-of-a-maternal-history-of-childhood-abuse-on-adrenocortical-attunement-in-mothers-and-their-toddlers
#18
Anna Fuchs, Eva Moehler, Franz Resch, Michael Kaess
We investigated circadian mother-child adrenocortical attunement in the context of a maternal history of childhood abuse (HoA). Mothers were screened after birth using the Childhood Trauma Questionnaire. Women reporting moderate or severe abuse formed the HoA group (n = 37; HoAG) and were compared with a non-maltreated comparison group (n = 45; CG). Three years later, cortisol awakening response (CAR) and diurnal slope (DSL) were assessed. Mother-child interaction was coded using the Emotional Availability Scales at 12 months of age...
June 2, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28573658/an-approach-to-understanding-sleep-and-depressed-mood-in-adolescents-person-centred-sleep-classification
#19
Tamar Shochat, David H Barker, Katherine M Sharkey, Eliza Van Reen, Brandy M Roane, Mary A Carskadon
Depressive mood in youth has been associated with distinct sleep dimensions, such as timing, duration and quality. To identify discrete sleep phenotypes, we applied person-centred analysis (latent class mixture models) based on self-reported sleep patterns and quality, and examined associations between phenotypes and mood in high-school seniors. Students (n = 1451; mean age = 18.4 ± 0.3 years; 648 M) completed a survey near the end of high-school. Indicators used for classification included school night bed- and rise-times, differences between non-school night and school night bed- and rise-times, sleep-onset latency, number of awakenings, naps, and sleep quality and disturbance...
June 2, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28570945/the-impact-of-short-term-clinical-placement-in-a-developing-country-on-nursing-students-a-qualitative-descriptive-study
#20
Ingeborg Ulvund, Elin Mordal
BACKGROUND: Offering nursing students' international clinical placement during the educational program is one response to meet the need of cultural competence among nurses. This paper provides insight into the impact of clinical placement, in a developing country, on third year nursing students. In the study we investigated how short term international clinical placement impacted Norwegian nursing students' development of cultural competency. DESIGN AND METHODS: In this study we utilised a qualitative descriptive design and used individual interviews with eighteen Norwegian nursing students who had all participated in an international clinical placement...
August 2017: Nurse Education Today
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