keyword
MENU ▼
Read by QxMD icon Read
search

diabetes obesity hormones

keyword
https://www.readbyqxmd.com/read/29780358/sex-and-gender-differences-in-prevention-of-type-2-diabetes
#1
REVIEW
Jürgen Harreiter, Alexandra Kautzky-Willer
Lifestyle intervention programs are effective in the prevention of type 2 diabetes mellitus (T2DM) in high risk populations. However, most studies only give limited information about the influence of sex and/or gender effectiveness of these interventions. So far, similar outcome was reported for diabetes progression and weight loss. Nevertheless, long-term data on cardiovascular outcome are sparse but favoring women regarding all-cause and cardiovascular mortality. In both men and women, sex hormone imbalances and reproductive disorders are associated with a higher risk of T2DM development...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29768196/loss-of-abhd15-impairs-the-anti-lipolytic-action-of-insulin-by-altering-pde3b-stability-and-contributes-to-insulin-resistance
#2
Wenmin Xia, Ariane R Pessentheiner, Dina C Hofer, Melina Amor, Renate Schreiber, Gabriele Schoiswohl, Thomas O Eichmann, Evelyn Walenta, Bianca Itariu, Gerhard Prager, Hubert Hackl, Thomas Stulnig, Dagmar Kratky, Thomas Rülicke, Juliane G Bogner-Strauss
Elevated circulating fatty acids (FAs) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. We show that α/β-hydrolase domain-containing 15 (ABHD15) is required for the anti-lipolytic action of insulin in white adipose tissue (WAT). Neither insulin nor glucose treatments can suppress FA mobilization in global and conditional Abhd15-knockout (KO) mice. Accordingly, insulin signaling is impaired in Abhd15-KO adipocytes, as indicated by reduced AKT phosphorylation, glucose uptake, and de novo lipogenesis...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29767698/mechanisms-by-which-dietary-fatty-acids-regulate-mitochondrial-structure-function-in-health-and-disease
#3
E Madison Sullivan, Edward Ross Pennington, William D Green, Melinda A Beck, David A Brown, Saame Raza Shaikh
Mitochondria are the energy-producing organelles within a cell. Furthermore, mitochondria have a role in maintaining cellular homeostasis and proper calcium concentrations, building critical components of hormones and other signaling molecules, and controlling apoptosis. Structurally, mitochondria are unique because they have 2 membranes that allow for compartmentalization. The composition and molecular organization of these membranes are crucial to the maintenance and function of mitochondria. In this review, we first present a general overview of mitochondrial membrane biochemistry and biophysics followed by the role of different dietary saturated and unsaturated fatty acids in modulating mitochondrial membrane structure-function...
May 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29764860/membrane-initiated-estrogen-receptor-signaling-mediates-metabolic-homeostasis-via-central-activation-of-protein-phosphatase-2a
#4
Kazutaka Ueda, Eiki Takimoto, Qing Lu, Pangyen Liu, Nobuaki Fukuma, Yusuke Adachi, Ryo Suzuki, Shengpu Chou, Wendy Baur, Mark J Aronovitz, Andrew S Greenberg, Issei Komuro, Richard H Karas
Women gain weight and their diabetes risk increases as they transition through menopause; these changes can in part be reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen receptor (ER) pathway was employed, and we found that the lack of this pathway precipitated excessive weight gain and glucose intolerance independent of food intake, and that this was accompanied by impaired adaptive thermogenesis and reduced physical activity...
May 15, 2018: Diabetes
https://www.readbyqxmd.com/read/29758041/acute-effects-of-insulin-on-circulating-natriuretic-peptide-levels-in-humans
#5
Katherine N Bachmann, Serpil Muge Deger, Aseel Alsouqi, Shi Huang, Meng Xu, Jane F Ferguson, Yan Ru Su, Kevin D Niswender, T Alp Ikizler, Thomas J Wang
BACKGROUND: The natriuretic peptide hormones play an important role in salt and blood pressure regulation. In observational studies, obesity and insulin resistance have been consistently associated with lower concentrations of natriuretic peptides. It has been proposed that insulin influences natriuretic peptide production. OBJECTIVE: We sought to determine the acute effects of insulin administration on natriuretic peptide concentrations. METHODS: 31 men and women (11 lean, 10 overweight, and 10 obese), ages 30-70 years, without cardiovascular disease or overt diabetes underwent a hyperinsulinemic-euglycemic insulin clamp...
2018: PloS One
https://www.readbyqxmd.com/read/29752333/the-endocrinology-of-male-breast-cancer
#6
REVIEW
Ian S Fentiman
Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E2 ) levels from hepatic conversion of androgen...
June 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29744905/insulin-resistance-and-sex-hormone-binding-globulin-are-independently-correlated-with-low-free-testosterone-levels-in-obese-males
#7
P Souteiro, S Belo, S C Oliveira, J S Neves, D Magalhães, J Pedro, R Bettencourt-Silva, M M Costa, A Varela, J Queirós, P Freitas, D Carvalho
Male obesity is associated with decreased testosterone levels but the pathophysiological mechanisms behind this association are not completely understood. This study aimed to investigate the impact of hyperglycaemia/insulin resistance and sex hormone-binding globulin (SHBG) levels on testosterone levels in a population of obese men. We investigated the impact of several clinical, anthropometric and analytic measures on testosterone levels in 150 obese males. Testosterone deficiency was present in 52.0% of the enrolled patients...
May 9, 2018: Andrologia
https://www.readbyqxmd.com/read/29737067/-correlation-between-testosterone-and-metabolic-index-in-male-patients-with-type-2-diabetes-mellitus
#8
Wen Cao, Ren-Dong Zheng, Yao-Fu Fan, Chao Liu
OBJECTIVE: To determine the effect of testosterone on serum glucose,lipid,uric acid and insulin metabolism in male patients with type 2 diabetes mellitus. METHODS: A total of 205 male patients with type 2 diabetes participated in this study. They were divided into two groups: those with normal testosterone (TT) (TT≥12 nmol/L, n =135) and those with low TT (TT<12 nmol/L, n =70). Their body mass,waist circumference (WC),body mass index (BMI),blood glucose, total cholesterol (TC), triglycerides (TG), serum uric acid (SUA),insulin,testosterone,luteinizing hormone (LH),follicle stimulating hormone (FSH),estradiol (E2),and sex hormone binding globulin (SHBG) were measured...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29731021/pathophysiological-links-between-diabetes-and-blood-pressure
#9
REVIEW
Renata Libianto, Duygu Batu, Richard J MacIsaac, Mark E Cooper, Elif I Ekinci
Hypertension is highly prevalent among people with diabetes, and the presence of diabetes among those with hypertension portends an increase in cardiovascular risk. In this review we aim to explore the pathophysiological links between diabetes and hypertension. Renal sodium handling differs in diabetes because there is an upregulation of sodium transporters in the kidneys. The renin-angiotensin-aldosterone system may be upregulated in diabetes, leading to hypertension through a direct effect mediated by angiotensin II, as well as indirectly through upregulation of sympathetic activity...
May 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29728598/glucagon-like-peptide-1-in-health-and-disease
#10
REVIEW
Andreas Andersen, Asger Lund, Filip K Knop, Tina Vilsbøll
In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates insulin release and suppresses glucagon secretion in response to the ingestion of nutrients. GLP1 also delays gastric emptying and increases satiety. In patients with type 2 diabetes mellitus (T2DM), supraphysiological doses of GLP1 normalize the endogenous insulin response during a hyperglycaemic clamp. Owing to the short plasma half-life of native GLP1, several GLP1 receptor agonists (GLP1RAs) with longer half-lives have been developed for the treatment of T2DM...
May 4, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29727594/fibroblast-growth-factor-21-a-versatile-regulator-of-metabolic-homeostasis
#11
Lucas D BonDurant, Matthew J Potthoff
Fibroblast growth factor 21 (FGF21) is an endocrine hormone derived from the liver that exerts pleiotropic effects on the body to maintain overall metabolic homeostasis. During the past decade, there has been an enormous effort made to understand the physiological roles of FGF21 in regulating metabolism and to identify the mechanism for its potent pharmacological effects to reverse diabetes and obesity. Through both human and rodent studies, it is now evident that FGF21 levels are dynamically regulated by nutrient sensing, and consequently FGF21 functions as a critical regulator of nutrient homeostasis...
May 4, 2018: Annual Review of Nutrition
https://www.readbyqxmd.com/read/29725251/glucagon-like-peptide-1-receptor-agonist-and-glucagon-increase-glucose-stimulated-insulin-secretion-in-beta-cells-via-distinct-adenylyl-cyclases
#12
Young-Sun Lee, Hee-Sook Jun
Diabetes mellitus is a chronic disease in which the pancreas no longer produces enough insulin. Pancreatic alpha cell mass increases in response to insufficient insulin secretion. However, the reason for this increase is not clear. It is possible that the increased alpha-cells may stimulate compensatory insulin release in response to the insufficient insulin such as insulin resistance. In this study, we investigated whether glucagon and glucagon-like peptide-1 (GLP-1), hormones produced by alpha cells, contribute to insulin secretion in INS-1 cells, a beta cell line...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29723655/effects-of-aging-and-insulin-resistant-states-on-protein-anabolic-responses-in-older-adults
#13
REVIEW
Jose A Morais, Kathryn Jacob, Stéphanie Chevalier
Insulin is the principal postprandial anabolic hormone and resistance to its action could contribute to sarcopenia. We developed different types of hyperinsulinemic clamp protocols to measure glucose and protein metabolism in insulin resistant states (older adults, obesity, diabetes, etc.). To define effects of healthy aging in response to insulin, we employed the hyperinsulinemic, euglycemic and isoaminoacidemic (HYPER-1) clamp. The net whole-body anabolic (protein balance) response to hyperinsulinemia was lower in the elderly vs young (p = 0...
April 30, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29723152/-the-role-of-single-nucleotide-polymorphisms-in-gipr-gene-in-the-changes-of-secretion-in-hormones-and-adipokines-in-patients-with-obesity-with-type-2-diabetes
#14
D A Skuratovskaia, M A Vulf, E V Kirienkova, N I Mironyuk, P A Zatolokin, L S Litvinova
The relationship between the rs2302382, rs8111428 and Glu354Gln (rs1800437) polymorphisms in GIPR (glucosedependent insulinotropic polypeptide receptor) gene and plasma levels of mediators involved in the regulation of carbohydrate metabolism in obese patients with type 2 diabetes (before and after a test breakfast) was investigated. The contribution of polymorphic variants of rs2302382, rs8111428 in GIPR gene in the predisposition to type 2 diabetes in individuals belonging to the Slavic population of Russia was found...
March 2018: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29720835/combination-of-garcinia-cambogia-extract-and-pear-pomace-extract-additively-suppresses-adipogenesis-and-enhances-lipolysis-in-3t3-l1-cells
#15
Kushal Sharma, Siwon Kang, Dalseong Gong, Sung-Hwa Oh, Eun-Young Park, Min-Ho Oak, Eunyoung Yi
Background: Inhibition of adipogenesis has been a therapeutic target for reducing obesity and obesity-related disorders such as diabetes, hypertension, atherosclerosis, and cancer. For decades, anti-adipogenic potential of many herbal extracts has been investigated. One example is Garcinia cambogia extract (GE) containing (-)-hydroxycitric acid as an active ingredient. GE is currently marketed as a weight loss supplement, used alone or with other ingredients. Pear pomace extract (PE), another natural product, has been also shown to have anti-adipogenic activity in a recent report...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29717162/growth-differentiation-factor-15-ameliorates-nonalcoholic-steatohepatitis-and-related-metabolic-disorders-in-mice
#16
Kook Hwan Kim, Seong Hun Kim, Dai Hoon Han, Young Suk Jo, Yong-Ho Lee, Myung-Shik Lee
Growth differentiation factor 15 (GDF15) is an endocrine hormone belonging to the TGFβ superfamily member. GDF15 administration or GDF15 overexpression has been reported to have anti-obesity and anti-diabetic effects. Although non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is frequently associated with obesity and insulin resistance, the functional role of endogenous GDF15 and therapeutic effect of GDF15 overexpression in NASH and related metabolic deterioration have not been evaluated...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29716897/prospective-randomized-biomarker-study-of-metformin-and-lifestyle-intervention-for-prevention-in-obese-women-at-increased-risk-for-endometrial-cancer
#17
Melinda S Yates, Adriana M Coletta, Qian Zhang, Rosemarie E Schmandt, Meena Medepalli, Denise R Nebgen, Beth Soletsky, Andrea Milbourne, Erma Levy, Bryan M Fellman, Diana L Urbauer, Ying Yuan, Russell R Broaddus, Karen Basen-Engquist, Karen Lu
Obesity increases risk of endometrial cancer through dysregulation of estrogen and insulin signaling. The primary aim of this study was to evaluate the impact of metformin or lifestyle intervention on endometrial proliferation in postmenopausal obese women. Secondary aims included evaluating obesity-related biomarkers and adverse events experienced. Obese, postmenopausal women with pre-diabetes were randomized into four groups for a 16-week intervention using a 2 (metformin 1700 mg/day vs placebo) x 2 (lifestyle intervention vs no lifestyle intervention) factorial design...
May 1, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29713614/the-relation-of-obesity-related-hormonal-and-cytokine-levels-with-multiple-myeloma-and-non-hodgkin-lymphoma
#18
REVIEW
H Dean Hosgood, Marc J Gunter, Neil Murphy, Thomas E Rohan, Howard D Strickler
This article presents the first detailed overview of the mechanisms that may underlie the relation of obesity with B-cell non-Hodgkin lymphomas (NHLs) and multiple myeloma (MM). Epidemiologic studies, including meta-analyses of prospective cohorts, have reported that the risks of NHL and MM are significantly increased in obese, relative to normal weight, women and men. Accumulating experimental and clinical evidence suggests that inflammatory cytokines, hyperinsulinemia, and sex hormones could play a role in the association of obesity with B-cell NHL and MM carcinogenesis...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29710852/association-of-insulin-resistance-with-bone-strength-and-bone-turnover-in-menopausal-chinese-singaporean-women-without-diabetes
#19
Maria Kalimeri, Francesca Leek, Nan Xin Wang, Huann Rong Koh, Nicole C Roy, David Cameron-Smith, Marlena C Kruger, Christiani Jeyakumar Henry, John J Totman
Insulin resistance (IR) is accompanied by increased areal or volumetric bone mineral density (aBMD or vBMD), but also higher fracture risk. Meanwhile, imbalances in bone health biomarkers affect insulin production. This study investigates the effect of IR on proximal femur and lumbar spine BMD, femoral neck bending, compressive and impact strength indices (Composite Strength Indices) and circulating levels of parathyroid hormone (PTH), C-telopeptide of Type I collagen (CTx-1) and 25(OH) Vitamin D₃, in a cohort of 97 healthy, non-obese, menopausal Chinese-Singaporean women...
April 30, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29708829/the-impact-of-testosterone-replacement-therapy-on-glycemic-control-vascular-function-and-components-of-the-metabolic-syndrome-in-obese-hypogonadal-men-with-type-2-diabetes
#20
Kristina Groti, Ivan Žuran, Blaž Antonič, Lidija Foršnarič, Marija Pfeifer
OBJECTIVE: This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2). STUDY DESIGN: Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n = 28) was treated with testosterone undecanoate (1000 mg i...
April 30, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
keyword
keyword
113770
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"