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blepharitis ivermectin

Leon H Kircik, James Q Del Rosso, Alison M Layton, Jürgen Schauber
Although the broad-spectrum anti-parasitic effects of the avermectin derivative ivermectin are well documented, its anti-inflammatory activity has only recently been demonstrated. For over 25 years, ivermectin has been used to treat parasitic infections in mammals, with a good safety profile that may be attributed to its high affinity to invertebrate neuronal ion channels and its inability to cross the blood-brain barrier in humans and other mammals. Numerous studies report low rates of adverse events, as an oral treatment for parasitic infections, scabies and head lice...
March 2016: Journal of Drugs in Dermatology: JDD
S Hirsch-Hoffmann, C Kaufmann, P B Bänninger, M A Thiel
BACKGROUND: Demodex mites are microscopic parasites that live around hair follicles or sebaceous glands and may cause chronic blepharitis. The aim of this outcome analysis was to assess the efficacy and patient preferences with regard to the currently recommended treatment options. METHODS: All patients with microscopic evidence for Demodex blepharitis were informed about the currently published treatments and instructed about daily lid hygiene. Additional topical treatment options included tea tree oil (TTO) 5%, a cleansing foam containing 0...
April 2015: Klinische Monatsblätter Für Augenheilkunde
Doaa Abdel-Badie Salem, Atef El-Shazly, Nairmen Nabih, Youssef El-Bayoumy, Sameh Saleh
OBJECTIVE: To evaluate the efficacy of ivermectin and combined ivermectin-metronidazole therapy in the treatment of ocular and skin lesions of Demodex folliculorum. METHODS: One hundred twenty patients with skin lesions and anterior blepharitis, whose infestation was treatment-resistant and who had a Demodex count >5 mites/cm² for skin lesions or ≥ 3 mites at the root of each eyelash, were recruited. The treatment regimens were ivermectin and ivermectin-metronidazole combined therapy...
May 2013: International Journal of Infectious Diseases: IJID
Paulo Pimenta, Luís Cardoso, Maria J Pereira, Luís Maltez, Teresa Coutinho, Maria S Alves, Domenico Otranto
Ocular thelaziosis caused by Thelazia callipaeda is a vector-borne disease affecting dogs and humans. We report a case of thelaziosis in a 10-year-old German Shepherd dog from Vila Real city (Portugal). Ophthalmological examination revealed bulbar and nictitating membrane conjunctival hyperemia with serous discharge noted at the left medial canthus and blepharitis. Schirmer tear test value and intraocular pressure were within the reference ranges in both eyes, and biomicroscopy showed a transparent cornea without lesions or edema and no inflammatory reaction in the anterior chamber...
July 2013: Veterinary Ophthalmology
Flávio Gaieta Holzchuh, Richard Yudi Hida, Bernardo Kaplan Moscovici, Marcos Bottene Villa Albers, Ruth Miyuki Santo, Newton Kara-José, Ricardo Holzchuh
PURPOSE: To report clinical outcomes of the treatment of ocular Demodex folliculorum with oral ivermectin. DESIGN: Noncomparative, interventional case series. METHODS: Setting. Institutional. Study Population. Twenty-four eyes of 12 patients (3 male and 9 female; mean age ± standard deviation, 50.4 ± 21.0 years) with refractory posterior blepharitis with the presence of D. folliculorum in lash samples were enrolled in this study. Intervention...
June 2011: American Journal of Ophthalmology
C Martinaud, T Gaillard, S Pons, B Fournier, P Brisou
We present a 73-year-old woman presented to our hospital with a 2 years history of eyes itching. The ophthalmological testing was normal. Physical examination revealed blepharitis and lesions acnea-like on mouth, nose and chest. Biological testing revealed no abnormalities. Histologic study and direct immunofluorescence on a cutaneous biopsy were no contributive. The research of an allergic origine was practised by cutaneous and serological tests and negative. An examination of eyelashes was performed and yielded Demodex...
November 2009: Annales de Biologie Clinique
P Nenoff, W Handrick, C Krüger, J Herrmann, B Schmoranzer, U Paasch
Ectoparasites or epidermal parasites include a very heterogenous group of infections of the outer layers of the skin. Worldwide the most common are scabies, lice, tungiasis, and hookworm-induced cutaneous larva migrans. In recent years, bed bug infestations in hotels or vacation homes seem to have become more frequent. Demodex folliculorum and Demodex brevis are found in the facial and scalp hair follicles in 95% of individuals. Classic Demodex folliculitis is often overlooked in differential diagnostic considerations...
September 2009: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Damian Czepita, Wanda Kuźna-Grygiel, Maciej Czepita, Andrzej Grobelny
INTRODUCTION: Intensive long-term studies of Demodex spp. (D.) and its role in chronic blepharits have been carried out in recent years by scientists from the Pomeranian Medical University in Szczecin. It has resulted in numerous publications, spurring a lot of interest worldwide. A few of the papers have been cited in leading American medical journals. In recent years many papers dealing with demodicosis of the eyelids have been published worldwide. Based on the growing interest in the role of Demodex spp...
2007: Annales Academiae Medicae Stetinensis
E Clyti, K Sayavong, K Chanthavisouk
INTRODUCTION: Demodex is a saprophyte parasite in mammals. In Man, it is associated with differing clinical profiles (rosacea-like dermatitis, folliculitis and blepharitis). We report a case of demodecidosis in an HIV-infected patient that was successfully treated with ivermectin. CASE REPORT: A man from Laos, infected by HIV and treated for glandular tuberculosis, presented with a prurigenous eruption on the face and the pre-sternal and interscapular areas. Direct examination of scraped product and histopathological examinations confirmed the diagnosis of demodecidosis...
May 2005: Annales de Dermatologie et de Vénéréologie
Blanca María Morfin Maciel
A 65-year old woman suffered from therapy resistant chronic blepharoconjunctivitis and rosacea, without improvement under therapy of systemic and topic antibiotics and topic steroids and antihistamines. Demodex folliculorum was found adhered to the hair bulb on microscopic examination. She received oral ivermectin with good response. Two months later demodicidosis recurred. Then she was treated with a combination of ivermectin and transfer factor with total remission. Demodex folliculorum considered as saprophytic mite may play a pathogenic role in ocular diseases...
November 2003: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
Diona Damian, Maureen Rogers
BACKGROUND: Demodex mites are almost ubiquitous on older adult skin but are infrequent in young children. In immunocompromised patients, demodicosis may be more frequent and severe, and systemic therapy may be needed to achieve clinical resolution. CASE REPORT: A six-year-old boy having maintenance chemotherapy for acute lymphoblastic leukemia presented with widespread erythema and scaling of the face. Skin scrapings were negative and the eruption worsened despite the completion of chemotherapy and the use of topical corticosteroids...
September 2003: International Journal of Dermatology
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