keyword
Keywords Hypothermia after out of hospi...

Hypothermia after out of hospital arrest

https://read.qxmd.com/read/37702779/-procedure-after-successful-cardiopulmonary-resuscitation-cooling-or-no-more-cooling
#21
REVIEW
Kevin Roedl, Sebastian Wolfrum, Stefan Kluge
Approximately 84 out of 100,000 inhabitants in Europe suffer from an out of hospital cardiac arrest (OHCA) each year. The mortality after cardiac arrest (CA) is high and is particularly determined by the predominant cardiogenic shock condition and hypoxic ischemic encephalopathy. For almost two decades hypothermic temperature control was the only neuroprotective intervention recommended in guidelines for postresuscitation care; however, recently published studies failed to demonstrate any improvement in the neurological outcome with hypothermia in comparison to strict normothermia in postresuscitation treatment...
October 2023: Inn Med (Heidelb)
https://read.qxmd.com/read/37634862/comparison-of-four-clinical-risk-scores-in-comatose-patients-after-out-of-hospital-cardiac-arrest
#22
JOURNAL ARTICLE
Simon Schmidbauer, Christian Rylander, Alain Cariou, Matt P Wise, Matthew Thomas, Thomas R Keeble, David Erlinge, Matthias Haenggi, Pedro D Wendel-Garcia, Jan Bělohlávek, Anders Morten Grejs, Niklas Nielsen, Hans Friberg, Josef Dankiewicz
BACKGROUND AND AIMS: Several different scoring systems for early risk stratification after out-of-hospital cardiac arrest have been developed, but few have been validated in large datasets. The aim of the present study was to compare the well-validated Out-of-hospital Cardiac Arrest (OHCA) and Cardiac Arrest Hospital Prognosis (CAHP)-scores to the less complex MIRACLE2- and Target Temperature Management (TTM)-scores. METHODS: This was a post-hoc analysis of the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial...
October 2023: Resuscitation
https://read.qxmd.com/read/37633944/neuropsychological-outcome-after-cardiac-arrest-results-from-a-sub-study-of-the-targeted-hypothermia-versus-targeted-normothermia-after-out-of-hospital-cardiac-arrest-ttm2-trial
#23
JOURNAL ARTICLE
Erik Blennow Nordström, Susanna Vestberg, Lars Evald, Marco Mion, Magnus Segerström, Susann Ullén, John Bro-Jeppesen, Hans Friberg, Katarina Heimburg, Anders M Grejs, Thomas R Keeble, Hans Kirkegaard, Hanna Ljung, Sofia Rose, Matthew P Wise, Christian Rylander, Johan Undén, Niklas Nielsen, Tobias Cronberg, Gisela Lilja
BACKGROUND: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was to investigate the relationship between cognitive performance and the associated factors of emotional problems, fatigue, insomnia, and cardiovascular risk factors following OHCA...
August 26, 2023: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/37629339/sex-difference-on-neurological-outcomes-and-post-cardiac-arrest-care-in-out-of-hospital-cardiac-arrest-patients-treated-with-targeted-temperature-management-post-hoc-study-of-a-prospective-multicenter-observational-cohort-study
#24
JOURNAL ARTICLE
Seon Yeong Park, Sang Hoon Oh, Sang Hyun Park, Jae Hun Oh, Soo Hyun Kim
Conflicting results regarding sex-based differences in the outcomes of out-of-hospital cardiac arrest (OHCA) patients have been reported. We aimed to evaluate the association between sex and neurological outcome as well as various in-hospital process in OHCA patients treated with targeted temperature management. We retrospectively analyzed a prospective registry data collected between October 2015 and December 2018. To evaluate the effect of sex on patient outcomes, we created various multivariable logistic regression models...
August 14, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37611576/-targeted-temperature-management-after-cardiac-arrest
#25
JOURNAL ARTICLE
Sandra Finkbeiner, Katrin Fink, Hans-Jörg Busch
Actively avoiding fever is the only possibility to improve neurological outcome after cardiac arrest. It is uncertain if and which patients benefit from a lower target temperature. The ERC Guidelines in 2021 recommended targeted temperature management (TTM) for all patients after in- and out-of-hospital cardiac arrest with a target temperature of 32-36 °C for at least 24 hours. These recommendations were updated in 2022 by the ERC/ESICM Guidelines suggesting to avoid fever only within the first 72 hours after the event...
September 2023: Deutsche Medizinische Wochenschrift
https://read.qxmd.com/read/37584195/temperature-management-for-comatose-adult-survivors-of-cardiac-arrest-a-science-advisory-from-the-american-heart-association
#26
REVIEW
Sarah M Perman, Jason A Bartos, Marina Del Rios, Michael W Donnino, Karen G Hirsch, Jacob C Jentzer, Peter J Kudenchuk, Michael C Kurz, Carolina B Maciel, Venu Menon, Ashish R Panchal, Jon C Rittenberger, Katherine M Berg
Targeted temperature management has been a cornerstone of post-cardiac arrest care for patients remaining unresponsive after return of spontaneous circulation since the initial trials in 2002 found that mild therapeutic hypothermia improves neurological outcome. The suggested temperature range expanded in 2015 in response to a large trial finding that outcomes were not better with treatment at 33° C compared with 36° C. In 2021, another large trial was published in which outcomes with temperature control at 33° C were not better than those of patients treated with a strategy of strict normothermia...
September 19, 2023: Circulation
https://read.qxmd.com/read/37559163/different-neuroprognostication-thresholds-of-neuron-specific-enolase-in-shockable-and-non-shockable-out-of-hospital-cardiac-arrest-a-prospective-multicenter-observational-study-in-korea-the-korhn-pro-registry
#27
MULTICENTER STUDY
Youn-Jung Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Byung Kook Lee, Won Young Kim
BACKGROUND: Serum neuron-specific enolase (NSE) is the only recommended biomarker for multimodal prognostication in postcardiac arrest patients, but low sensitivity of absolute NSE threshold limits its utility. This study aimed to evaluate the prognostic performance of serum NSE for poor neurologic outcome in out-of-hospital cardiac arrest (OHCA) survivors based on their initial rhythm and to determine the NSE cutoff values with false positive rate (FPR) < 1% for each group...
August 9, 2023: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/37548968/effects-of-hypothermia-vs-normothermia-on-societal-participation-and-cognitive-function-at-6-months-in-survivors-after-out-of-hospital-cardiac-arrest-a-predefined-analysis-of-the-ttm2-randomized-clinical-trial
#28
JOURNAL ARTICLE
Gisela Lilja, Susann Ullén, Josef Dankiewicz, Hans Friberg, Helena Levin, Erik Blennow Nordström, Katarina Heimburg, Janus Christian Jakobsen, Marita Ahlqvist, Frances Bass, Jan Belohlavek, Roy Bjørkholt Olsen, Alain Cariou, Glenn Eastwood, Hans Rune Fanebust, Anders M Grejs, Lisa Grimmer, Naomi E Hammond, Jan Hovdenes, Juraj Hrecko, Manuela Iten, Henriette Johansen, Thomas R Keeble, Hans Kirkegaard, Jean-Baptiste Lascarrou, Christoph Leithner, Mildred Eden Lesona, Anja Levis, Marco Mion, Marion Moseby-Knappe, Leanlove Navarra, Per Nordberg, Paolo Pelosi, Rachael Quayle, Christian Rylander, Helena Sandberg, Manoj Saxena, Claudia Schrag, Michal Siranec, Cassina Tiziano, Philippe Vignon, Pedro David Wendel-Garcia, Matt P Wise, Kim Wright, Niklas Nielsen, Tobias Cronberg
IMPORTANCE: The Targeted Hypothermia vs Targeted Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison of the 2 intervention regimens. OBJECTIVES: To investigate the effects of targeted hypothermia vs targeted normothermia on functional outcome with focus on societal participation and cognitive function in survivors 6 months after OHCA...
October 1, 2023: JAMA Neurology
https://read.qxmd.com/read/37537415/multiorgan-recovery-in-a-cadaver-body-using-mild-hypothermic-ecmo-treatment-in-a-murine-model
#29
JOURNAL ARTICLE
Nodir Madrahimov, Vitalii Mutsenko, Ruslan Natanov, Dejan Radaković, André Klapproth, Mohamed Hassan, Mathias Rosenfeldt, Florian Kleefeldt, Ivan Aleksic, Süleyman Ergün, Christoph Otto, Rainer G Leyh, Constanze Bening
BACKGROUND: Transplant candidates on the waiting list are increasingly challenged by the lack of organs. Most of the organs can only be kept viable within very limited timeframes (e.g., mere 4-6 h for heart and lungs exposed to refrigeration temperatures ex vivo). Donation after circulatory death (DCD) using extracorporeal membrane oxygenation (ECMO) can significantly enlarge the donor pool, organ yield per donor, and shelf life. Nevertheless, clinical attempts to recover organs for transplantation after uncontrolled DCD are extremely complex and hardly reproducible...
August 4, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/37510819/lazarus-phenomenon-or-the-return-from-the-afterlife-what-we-know-about-auto-resuscitation
#30
REVIEW
Piotr Rzeźniczek, Agnieszka Danuta Gaczkowska, Anna Kluzik, Marcin Cybulski, Alicja Bartkowska-Śniatkowska, Małgorzata Grześkowiak
Autoresuscitation is a phenomenon of the heart during which it can resume its spontaneous activity and generate circulation. It was described for the first time by K. Linko in 1982 as a recovery after discontinued cardiopulmonary resuscitation (CPR). J.G. Bray named the recovery from death the Lazarus phenomenon in 1993. It is based on a biblical story of Jesus' resurrection of Lazarus four days after confirmation of his death. Up to the end of 2022, 76 cases (coming from 27 countries) of spontaneous recovery after death were reported; among them, 10 occurred in children...
July 15, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37466218/rapid-selective-and-homogeneous-brain-cooling-with-transnasal-flow-of-ambient-air-for-pediatric-resuscitation
#31
JOURNAL ARTICLE
Raymond C Koehler, Michael Reyes, C Danielle Hopkins, Jillian S Armstrong, Suyi Cao, Ewa Kulikowicz, Jennifer K Lee, Harikrishna Tandri
Neurologic outcome from out-of-hospital pediatric cardiac arrest remains poor. Although therapeutic hypothermia has been attempted in this patient population, a beneficial effect has yet to be demonstrated, possibly because of the delay in achieving target temperature. To minimize this delay, we developed a simple technique of transnasal cooling. Air at ambient temperature is passed through standard nasal cannula with an open mouth to produce evaporative cooling of the nasal passages. We evaluated efficacy of brain cooling with different airflows in different size piglets...
July 19, 2023: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/37455296/serum-proteome-profiles-in-patients-treated-with-targeted-temperature-management-after-out-of-hospital-cardiac-arrest
#32
JOURNAL ARTICLE
Gabriele Lileikyte, Anahita Bakochi, Ashfaq Ali, Marion Moseby-Knappe, Tobias Cronberg, Hans Friberg, Gisela Lilja, Helena Levin, Filip Årman, Sven Kjellström, Josef Dankiewicz, Christian Hassager, Johan Malmström, Niklas Nielsen
BACKGROUND: Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome profiles from unconscious patients admitted to hospital after out-of-hospital cardiac arrest according to temperature treatment and neurological outcome...
July 17, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/37326919/just-the-facts-management-of-return-of-spontaneous-circulation-after-out-of-hospital-cardiac-arrest
#33
JOURNAL ARTICLE
Hashim Kareemi, Ariel Hendin, Christian Vaillancourt
No abstract text is available yet for this article.
July 2023: CJEM
https://read.qxmd.com/read/37219970/the-effect-of-targeted-temperature-management-on-the-metabolome-following-out-of-hospital-cardiac-arrest
#34
JOURNAL ARTICLE
Rasmus Paulin Beske, Laust Emil Roelsgaard Obling, John Bro-Jeppesen, Niklas Nielsen, Martin Abild Steengaard Meyer, Jesper Kjaergaard, Pär Ingemar Johansson, Christian Hassager
Targeted temperature management (TTM) may moderate the injury from out-of-hospital cardiac arrest. Slowing the metabolism has been a suggested effect. Nevertheless, studies have found higher lactate levels in patients cooled to 33°C compared with 36°C even days from TTM cessation. Larger studies have not been performed on the TTM's effect on the metabolome. Accordingly, to explore the effect of TTM, we used ultra-performance liquid-mass spectrometry in a substudy of 146 patients randomized in the TTM trial to either 33°C or 36°C for 24 hours and quantified 60 circulating metabolites at the time of hospital arrival (T0 ) and 48 hours later (T48 )...
May 23, 2023: Therapeutic Hypothermia and Temperature Management
https://read.qxmd.com/read/37219575/prognostic-performance-of-initial-clinical-examination-in-predicting-good-neurological-outcome-in-cardiac-arrest-patients-treated-with-targeted-temperature-management
#35
JOURNAL ARTICLE
Ji-Sook Lee, Hyo Jin Bang, Chun Song Youn, Soo Hyun Kim, SangHyun Park, Hyo Joon Kim, Kyu Nam Park, Sang Hoon Oh
Prognostication studies of cardiac arrest patients have mainly focused on poor neurological outcomes. However, an optimistic prognosis for good outcome could provide both justification to maintain and escalate treatment and evidence-based support to persuade family members or legal surrogates after cardiac arrest. The aim of the study was to evaluate the utility of clinical examinations performed after return of spontaneous circulation (ROSC) in predicting good neurological outcomes in out-of-hospital cardiac arrest (OHCA) patients treated with targeted temperature management (TTM)...
May 19, 2023: Therapeutic Hypothermia and Temperature Management
https://read.qxmd.com/read/37218807/survival-with-good-neurological-outcome-despite-prolonged-cardiopulmonary-resuscitation-and-extreme-acidosis-after-out-of-hospital-cardiac-arrest-due-to-acute-myocardial-infarction-a-case-report-and-review-of-the-literature
#36
Sylvère Störmann, Kristina Busygina, Ralph Hein-Rothweiler, Julius Steffen, Stefanie Förderreuther, Nora Salein, Matthias W Angstwurm
We report the case of a 49-year-old male who suffered from a myocardial infarction with subsequent cardiac arrest. The emergency medical team began cardiopulmonary resuscitation, including defibrillation of ventricular fibrillation. Although a return of spontaneous circulation was achieved after approximately 30 min of continued efforts, the patient went back into cardiac arrest on the way to the hospital and resuscitation had to be resumed. On admission, the patient was severely acidotic with a pH of 6.67, lactatemia of 19 mmol/L, and pronounced hypercapnia (pCO2 127 mmHg)...
May 15, 2023: Clinics and Practice
https://read.qxmd.com/read/37178902/hypothermia-versus-normothermia-after-out-of-hospital-cardiac-arrest-the-effect-on-post-intervention-serum-concentrations-of-sedatives-and-analgesics-and-time-to-awakening
#37
RANDOMIZED CONTROLLED TRIAL
Martin Annborn, Ameldina Ceric, Ola Borgquist, Joachim During, Marion Moseby-Knappe, Anna Lybeck
BACKGROUND: This study investigated the association of two levels of targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) with administered doses of sedative and analgesic drugs, serum concentrations, and the effect on time to awakening. METHODS: This substudy of the TTM2-trial was conducted at three centers in Sweden, with patients randomized to either hypothermia or normothermia. Deep sedation was mandatory during the 40-hour intervention...
July 2023: Resuscitation
https://read.qxmd.com/read/37178901/validation-of-the-rcast-score-and-comparison-to-the-pcac-and-four-scores-for-prognostication-after-out-of-hospital-cardiac-arrest
#38
JOURNAL ARTICLE
Noah Kim, Eva Kitlen, Gabriella Garcia, Akhil Khosla, P Elliott Miller, Jennifer Johnson, Charles Wira, David M Greer, Emily J Gilmore, Rachel Beekman
AIM: Early, accurate outcome prediction after out-of-hospital cardiac arrest (OHCA) is critical for clinical decision-making and resource allocation. We sought to validate the revised post-Cardiac Arrest Syndrome for Therapeutic hypothermia (rCAST) score in a United States cohort and compare its prognostic performance to the Pittsburgh Cardiac Arrest Category (PCAC) and Full Outline of UnResponsiveness (FOUR) scores. METHODS: This is a single-center, retrospective study of OHCA patients admitted between January 2014-August 2022...
May 11, 2023: Resuscitation
https://read.qxmd.com/read/37133324/rewarming-young-children-after-drowning-associated-hypothermia-and-out-of-hospital-cardiac-arrest-analysis-using-the-case-report-guideline
#39
JOURNAL ARTICLE
Maya Caroline Andre, Raphael Nicolas Vuille-Dit-Bille, Andreas Berset, Jürg Hammer
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) is recommended in adults with drowning-associated hypothermia and out-of-hospital cardiac arrest (OHCA). Our experience of managing a drowned 2-year-old girl with hypothermia (23°C) and cardiac arrest (58 min) prompted this summary using the CAse REport (CARE) guideline to address the question of optimal rewarming procedure in such patients. DESIGN/PATIENTS: Following the CARE guideline, we identified 24 reports in the "PubMed database" describing children less than or equal to 6 years old with a temperature less than or equal to 28°C who had been rewarmed using conventional intensive care ± ECMO...
September 1, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/37104654/changes-in-practice-of-controlled-hypothermia-after-cardiac-arrest-in-the-past-20-years-a-critical-care-perspective
#40
JOURNAL ARTICLE
Niklas Nielsen, Hans Friberg
For 20 years, induced hypothermia and targeted temperature management have been recommended to mitigate brain injury and increase survival after cardiac arrest. On the basis of animal research and small clinical trials, the International Liaison Committee on Resuscitation strongly advocated hypothermia at 32-34 °C for 12-24 hours for comatose patients with out-of-hospital cardiac arrest with initial rhythm of ventricular fibrillation or nonperfusing ventricular tachycardia. The intervention was implemented worldwide...
June 15, 2023: American Journal of Respiratory and Critical Care Medicine
keyword
keyword
11376
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.