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https://www.readbyqxmd.com/read/28226872/multimodel-quantitative-analysis-of-somatosensory-evoked-potentials-after-cardiac-arrest-with-graded-hypothermia
#1
Leanne Moon Young, Rishabh Choudhary, Xiaofeng Jia, Leanne Moon Young, Rishabh Choudhary, Xiaofeng Jia, Xiaofeng Jia, Leanne Moon Young, Rishabh Choudhary
Cardiac arrest (CA) is one of the most prominent causes of morbidity and mortality in adults. Therapeutic hypothermia (TH) is a recommended treatment to improve survival and functional outcome following CA, however, it is unclear what degree of TH is most beneficial. It has been suggested that TH of 33°C provides no survival or outcome benefits over TH of 36°C. Additionally, there is a lack of verified objective quantitative prognostic tools for comatose CA patients under TH. In this study, we calculated three quantitative markers of somatosensory evoked potentials (SSEP) to examine their potential to track recovery in the early period following CA under graded TH...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226731/automatic-detection-of-hemorrhage-and-surgical-instrument-in-laparoscopic-surgery-image
#2
Kyungmin Jo, Bareum Choi, Songe Choi, Youngjin Moon, Jaesoon Choi, Kyungmin Jo, Bareum Choi, Songe Choi, Youngjin Moon, Jaesoon Choi, Songe Choi, Jaesoon Choi, Bareum Choi, Youngjin Moon, Kyungmin Jo
In this paper, we propose a new method for detecting hemorrhage areas and surgical instruments in robot-assisted laparoscopic surgery images. The proposed scheme utilizes CIELAB information to identify a region of interest (ROI) and segment it. Histogram equalization and Otsu's method are also adopted to compute the detection threshold. Detection is performed automatically and additional adjustment of parameters is not needed. Experiments to verify the proposed algorithm were conducted using actual robot-assisted laparoscopic surgery images...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226509/design-of-a-dual-slot-antenna-for-small-animal-microwave-ablation-studies
#3
Tyler J Moon, Christopher L Brace, Tyler J Moon, Christopher L Brace, Christopher L Brace, Tyler J Moon
This study presents the development of a dual-slot antenna for small animal tumor ablation. By using a dual-slot design at 8 GHz, it was hypothesized that smaller and more spherical ablations can be produced. After computer-aided design optimization, antennas were fabricated and ablations performed at 5-20 W for 15-120 s with the objective of creating ablations with a diameter/length aspect ratio of at least 0.9. The new dual-slot design at 8 GHz created significantly more spherical ablations than a commercial antenna at 2...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226499/origami-microfluidic-paper-analytical-devices-ompad-for-sensing-and-diagnostics
#4
Meera Punjiya, Chung Hee Moon, Yu Chen, Sameer Sonkusale, Meera Punjiya, Chung Hee Moon, Yu Chen, Sameer Sonkusale, Yu Chen, Chung Hee Moon, Sameer Sonkusale, Meera Punjiya
Recent research activities in the area of low-cost sensing and diagnostics that are realized on cellulosic paper substrate are presented. First a three-dimensional origami paper-based analytical device (omPAD) with multiple electrochemical sensors, an integrated sample reservoir and tight integration with a custom CMOS potentiostat is presented. Second, an optical sensor array with built-in microfluidic channel for sample delivery is presented. The sensors are fabricated using a combination of wax printing and screen-printing using a solution based approach in ambient conditions without the need for expensive fabrication equipment or a cleanroom...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226202/predictors-of-acute-myocarditis-in-complicated-scrub-typhus-an-endemic-province-in-the-republic-of-korea
#5
Jung Yeon Chin, Ki-Woon Kang, Kyung Min Moon, Jongwoo Kim, Yu Jeong Choi
Background/Aims: Scrub typhus is known as a self-limited infectious disease. Cardiac complication is uncommon and usually not life-threatening. Until now, few cases of fulminant myocarditis by scrub typhus have been reported. So, we investigated incidence and predictors of acute myocarditis in severe scrub typhus. Methods: We retrospectively reviewed 89 patients among 91 scrub typhus confirmed patients who examined an echocardiogram and cardiac biomarkers from 2005 to 2015 in the intensive care unit at our hospital...
February 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28225994/a-rare-case-of-ectopic-acth-syndrome-originating-from-malignant-renal-paraganglioma
#6
Esra Tutal, Demet Yılmazer, Taner Demirci, Evrim Cakır, Salih Sinan Gültekin, Bahadır Celep, Oya Topaloğlu, Erman Çakal
Ectopic adrenocorticotropic hormone (ACTH) syndrome is characterized by hypercortisolism due to the hypersecretion of a non-pituitary ACTH-secreting tumor leading to Cushing's syndrome. Only a few cases have been reported previously as causing ectopic ACTH related to paraganglioma. Herein, we present a case of Cushing's syndrome, in who was proved to be attributable to an ACTH-secreting renal malignant paraganglioma. A 40-year-old woman presented with a five-month history of newly diagnosed hypertension and diabetes, weakness, hyperpigmentation, oligomenorrhea, hirsutism, and acneiform lesions...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225807/increased-liver-specific-proteins-in-circulating-extracellular-vesicles-as-potential-biomarkers-for-drug-and-alcohol-induced-liver-injury
#7
Young-Eun Cho, Eun-Ju Im, Pyong-Gon Moon, Esteban Mezey, Byoung-Joon Song, Moon-Chang Baek
Drug- and alcohol-induced liver injury are a leading cause of liver failure and transplantation. Emerging evidence suggests that extracellular vesicles (EVs) are a source of biomarkers because they contain unique proteins reflecting the identity and tissue-specific origin of the EV proteins. This study aimed to determine whether potentially hepatotoxic agents, such as acetaminophen (APAP) and binge alcohol, can increase the amounts of circulating EVs and evaluate liver-specific EV proteins as potential biomarkers for liver injury...
2017: PloS One
https://www.readbyqxmd.com/read/28225631/conformational-changes-in-c-reactive-protein-affect-binding-to-curved-membranes-in-a-lipid-bilayer-model-of-the-apoptotic-cell-surface
#8
Aml Abd Alnaas, Carrie L Moon, Mitchell Alton, Scott M Reed, Michelle K Knowles
C-reactive protein (CRP) is a serum protein that binds to damaged membranes through a phosphatidylcholine binding site. The membrane binding process can initiate the complement immune response and facilitates the clearance of apoptotic cells, likely aiding in the protection of autoimmunity. The initiation of an immune response relies on a conformation change from a native, pentameric form to a modified form, where the modified form binds complement proteins (i.e. C1q) and regulatory proteins substantially better than the native form...
February 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28225364/preoperative-risk-factors-of-c5-nerve-root-palsy-after-laminectomy-and-fusion-in-patients-with-cervical-myelopathy-analysis-of-70-consecutive-patients
#9
Kyung-Soo Suk, Kyung-Chung Kang, Hak-Sun Kim, Seong-Hwan Moon, Hwan-Mo Lee, Jung-Ho Seo, Sung-Min Kim, Sung-Yub Jin, Pierre Mella
STUDY DESIGN: A retrospective study. OBJECTIVE: To identify preoperative risk factors causing cervical fifth nerve root palsy (C5 palsy) after laminectomy and fusion (LF). SUMMARY OF BACKGROUND DATA: It is well known that postoperative C5 palsy is not rare after cervical surgery. Although there remains controversy, C5 palsy is considered to be more common in patients who had LF than in those who had laminoplasty. However, the reason for the higher incidence of C5 palsy in patients with LF has been poorly understood...
February 20, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28225083/antitumorigenic-effect-of-atmospheric-pressure-dielectric-barrier-discharge-on-human-colorectal-cancer-cells-via-regulation-of-sp1-transcription-factor
#10
Duksun Han, Jin Hyoung Cho, Ra Ham Lee, Woong Bang, Kyungho Park, Minseok S Kim, Jung-Hyun Shim, Jung-Il Chae, Se Youn Moon
Human colorectal cancer cell lines (HT29 and HCT116) were exposed to dielectric barrier discharge (DBD) plasma at atmospheric pressure to investigate the anticancer capacity of the plasma. The dose- and time-dependent effects of DBDP on cell viability, regulation of transcription factor Sp1, cell-cycle analysis, and colony formation were investigated by means of MTS assay, DAPI staining, propidium iodide staining, annexin V-FITC staining, Western blot analysis, RT-PCR analysis, fluorescence microscopy, and anchorage-independent cell transformation assay...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224644/clinical-effect-of-intratympanic-dexamethasone-injection-in-acute-unilateral-tinnitus-a-prospective-placebo-controlled-multicenter-study
#11
Hyun-Jin Lee, Min-Beom Kim, Shin-Young Yoo, Shi Nae Park, Eui-Cheol Nam, In Seok Moon, Ho-Ki Lee
OBJECTIVE: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin. STUDY DESIGN: A prospective, randomized, placebo-controlled, double-blinded, multicenter study. METHODS: Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28224059/identification-of-downy-mildew-resistance-gene-candidates-by-positional-cloning-in-maize-zea-mays-subsp-mays-poaceae
#12
Jae Yoon Kim, Jun-Cheol Moon, Hyo Chul Kim, Seungho Shin, Kitae Song, Kyung-Hee Kim, Byung-Moo Lee
PREMISE OF THE STUDY: Positional cloning in combination with phenotyping is a general approach to identify disease-resistance gene candidates in plants; however, it requires several time-consuming steps including population or fine mapping. Therefore, in the present study, we suggest a new combined strategy to improve the identification of disease-resistance gene candidates. METHODS AND RESULTS: Downy mildew (DM)-resistant maize was selected from five cultivars using a spreader row technique...
February 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28223757/attenuation-of-dickkopf-1-induced-hair-growth-inhibition-in-cultured-human-hair-follicles-by-tianeptine
#13
Hyun Sik Jeong, Mi Hee Kwack, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung
No abstract text is available yet for this article.
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223753/five-cases-of-phytophotodermatitis-caused-by-fig-leaves-and-relevant-literature-review
#14
Jin-Hwa Son, Hyunju Jin, Hyang-Suk You, Woo-Haing Shim, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
Phytophotodermatitis is a condition caused by sequential exposure to photosensitizing substances present in plants followed by ultraviolet light. Several plants (e.g., limes, celery, fig, and wild parsnip) contain furocoumarin compounds (psoralens). It is important for dermatologists to be aware of phytophotodermatitis because it may be misdiagnosed as cellulitis, tinea, or allergic contact dermatitis. We present five patients with a sharply defined erythematous swollen patch with bullae on both feet. They described soaking their feet in a fig leaves decoction to treat their underlying dermatologic diseases...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223742/insulin-like-growth-factor-1-increases-the-expression-of-inflammatory-biomarkers-and-sebum-production-in-cultured-sebocytes
#15
Hyojin Kim, Sun Young Moon, Mi Yeung Sohn, Weon Ju Lee
BACKGROUND: Acne vulgaris has been linked to the Western diet. Hyperglycemic diet increases insulin and insulin-like growth factor (IGF)-1. Deeper insights into IGF-1-mediated signal pathway are critical importance to understand the impact of Western diet. OBJECTIVE: We investigated the effect of IGF-1 on the expression of inflammatory biomarkers and sebum production in cultured sebocytes. METHODS: Polymerase chain reaction and enzyme-linked immunosorbent assay were performed to measure changes in the expression of inflammatory biomarkers including interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), IGF1R, IGFBP2, sterol response element-binding protein (SREBP), and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PI3KCA) after the treatment of cultured sebocytes with 10(-7) M or 10(-5) M IGF-1...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223739/effectiveness-of-specific-sublingual-immunotherapy-in-korean-patients-with-atopic-dermatitis
#16
Hyang-Suk You, Min-Young Yang, Gun-Wook Kim, Hyun-Ho Cho, Won-Jeong Kim, Je-Ho Mun, Margaret Song, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: Sublingual immunotherapy (SLIT) with house dust mites (HDM) preparation has recently been proven to be beneficial for treating allergic rhinitis and asthma. However, there has been no report regarding the efficacy and safety of SLIT in Korean patients with atopic dermatitis (AD). OBJECTIVE: We intended to investigate the efficacy and safety of SLIT in Korean patients with AD. METHODS: A total of 34 patients with AD and immunoglobulin E (IgE)-proven HDM sensitization (Class ≥3) were recruited...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223378/population-pharmacokinetic-analysis-of-doripenem-after-intravenous-infusion-in-korean-patients-with-acute-infections
#17
Dong-Hwan Lee, Yong Kyun Kim, Kyubok Jin, Myoung Joo Kang, Young-Don Joo, Yang Wook Kim, Young Soo Moon, Jae-Gook Shin, Sungmin Kiem
We investigated population pharmacokinetics (PK) of doripenem in Korean patients with acute infections, and determined an appropriate dosing regimen using a Monte-Carlo simulation for predicting pharmacodynamics (PD). Patients (n = 37) with a creatinine clearance (CLCR) of 20∼50 mL/min or >50 mL/min who received a 250-mg or 500-mg dose of doripenem over the course of one hour every eight hours, respectively, were included in this study. Blood samples were taken pre-dose and 0 h, 0.5 h, and 4-6 h after the fourth infusion...
February 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28223062/nivolumab-for-previously-treated-unresectable-metastatic-anal-cancer-nci9673-a-multicentre-single-arm-phase-2-study
#18
Van K Morris, Mohamed E Salem, Halla Nimeiri, Syma Iqbal, Preet Singh, Kristen Ciombor, Blase Polite, Dustin Deming, Emily Chan, James L Wade, Lianchun Xiao, Tanios Bekaii-Saab, Luis Vence, Jorge Blando, Armeen Mahvash, Wai Chin Foo, Chimela Ohaji, Manolo Pasia, Gail Bland, Aki Ohinata, Jane Rogers, Amir Mehdizadeh, Kimberly Banks, Richard Lanman, Robert A Wolff, Howard Streicher, James Allison, Padmanee Sharma, Cathy Eng
BACKGROUND: Squamous cell carcinoma of the anal canal (SCCA) is a rare malignancy associated with infection by human papillomavirus (HPV). No consensus treatment approach exists for the treatment of metastatic disease. Because intratumoral HPV oncoproteins upregulate immune checkpoint proteins such as PD-1 to evade immune-mediated cytotoxicity, we did a trial of the anti-PD-1 antibody nivolumab for patients with metastatic SCCA. METHODS: We did this single-arm, multicentre, phase 2 trial at ten academic centres in the USA...
February 17, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28222883/simplified-digital-workflow-for-dental-implant-restoration-on%C3%A2-a%C3%A2-stock%C3%A2-abutment-using-an-intraoral-scanner-a%C3%A2-dental%C3%A2-technique
#19
Jong-Eun Kim, Ji-Hyun Park, Hong-Seok Moon, June-Sung Shim
A straightforward digital restorative method based on a library of stock abutments is presented. Precisely scanned data of laboratory analog components of the stock abutment were obtained using a tabletop scanner to produce the library. The stock abutment and surrounding teeth, opposing arch, and occlusal information were recorded using an intraoral scanner. After transferring the scanned data to computer-aided design software, an appropriate library file for the abutment connected within the mouth was matched in order to design the prosthesis...
February 17, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28221283/comparison-of-acyclovir-and-famciclovir-for-ramsay-hunt-syndrome
#20
Ho Joong Kim, Junyang Jung, Sung Su Kim, Jae Yong Byun, Moon Suh Park, Seung Geun Yeo
OBJECTIVE: Although antiviral agents are widely used to treat Ramsay hunt syndrome (RHS), their relative effectiveness has not been assessed. This study retrospectively compared clinical outcomes in patients with RHS treated with the antiviral agents acyclovir and famciclovir. PATIENTS AND METHODS: This study involved 227 patients diagnosed with RHS from 2003 to 2015. Patients were treated with prednisolone plus acyclovir (n = 102) or famciclovir (n = 125)...
February 17, 2017: Otology & Neurotology
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