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https://www.readbyqxmd.com/read/28454457/detection-of-circulating-tumor-cells-in-patients-with-non-small-cell-lung-cancer-using-a-size-based-platform
#1
Chung-Hee Sonn, Jong Ho Cho, Jae-Won Kim, Moon Sung Kang, Jinseon Lee, Jhingook Kim
The detection of circulating tumor cells (CTCs) is limited by the rarity of these cells in the peripheral blood of patients with cancer. Understanding tumor biology may be useful in the development of novel therapeutic strategies for patients with lung cancer. The present study evaluated a novel size-based filtration platform for enriching CTCs from patients with lung cancer. Blood samples were obtained from 82 patients with lung cancer for CTC analysis. CTC enrichment by size-based filtration was performed on 5-ml blood samples...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454399/inhibition-of-lung-cancer-growth-by-hangamdan-b-is-mediated-by-macrophage-activation-to-m1-subtype
#2
Hye-Rin Park, Eun-Ji Lee, Seong-Cheol Moon, Tae-Wook Chung, Keuk-Jun Kim, Hwa-Seung Yoo, Chong-Kwan Cho, Ki-Tae Ha
Re-education of tumor-associated macrophages (TAMs) toward antitumor effectors may be a promising therapeutic strategy for the successful treatment of cancer. HangAmDan-B (HAD-B), a herbal formula, has been used for stimulating immune function and activation of vital energy to cancer patients in traditional Korean Medicine. Previous studies have reported the anti-angiogenic and anti-metastatic effects of HAD-B; however, evidence on the immunomodulatory action of HAD-B was not demonstrated. In the present study, immunocompetent mice were used to demonstrate the suppression of the in vivo growth of allograft Lewis lung carcinoma (LLC) cells, by HAD-B...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454348/effects-of-ptcs-on-nonsense-mediated-mrna-decay-are-dependent-on-ptc-location
#3
Heegyum Moon, Xuexiu Zheng, Tiing Jen Loh, Ha Na Jang, Yongchao Liu, Da-Woon Jung, Darren R Williams, Haihong Shen
The récepteur d'origine nantais (RON) gene is a proto-oncogene that is responsible for encoding the human macrophage-stimulating protein (MSP) 1 receptor. MSP activation induces RON-mediated cell dissociation, migration and matrix invasion. Isoforms of RON that exclude exons 5 and 6 encode the RONΔ160 protein, which promotes cell transformation in vitro and tumor metastasis in vivo. Premature termination codons (PTCs) in exons activate the nonsense-mediated mRNA decay (NMD) signaling pathway. The present study demonstrated that PTCs at various locations in the alternative exons 5 and 6 could induce NMD of the majority of the spliced, or partially spliced, isoforms...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453789/serum-tumor-necrosis-factor-receptor-1-is-associated-with-trajectories-of-functional-status-the-northern-manhattan-study
#4
Mandip S Dhamoon, Ying-Kuen Cheung, Yeseon P Moon, Clinton B Wright, Joshua Z Willey, Ralph L Sacco, Mitchell S V Elkind
We hypothesized that tumor necrosis factor receptor-1 (TNFR1) levels are associated with long-term trajectories of functional status independently of vascular risk factors and stroke and myocardial infarction (MI) occurring during follow-up. In the Northern Manhattan Study, stroke-free individuals in northern Manhattan aged >40 years had annual assessments with the Barthel index (BI) for a median of 13 years. Baseline demographics, risk factors, and laboratory studies included TNFR1 (n = 1,863). Generalized estimating equation models estimated standardized associations between TNFR1 and 1) baseline functional status and 2) change in function over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression, and stroke and MI occurring during follow-up...
April 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28453766/comparable-immune-function-inhibition-by-the-infliximab-biosimilar-ct-p13-implications-for-treatment-of-inflammatory-bowel-disease
#5
Ki Jung Lim, So Jung Lee, Sunghwan Kim, Su Yeon Lee, Min Seob Lee, Yoon A Park, Eun Jin Choi, Eun Beom Lee, Hwang Keun Jun, Jong Moon Cho, SooYoung Lee, Ki Sung Kwon, Byung Pil Lim, Myung-Shin Jeon, Eui Cheol Shin, Yong Sung Choi, Ella Fudim, Orit Picard, Miri Yavzori, Shomron Ben-Horin, Shin Jae Chang
Background and Aims: CT-P13 is the first biosimilar monoclonal antibody to infliximab, and was recently approved in the European Union, Japan, Korea, and USA for all six indications of infliximab. However, studies directly assessing the biologic activity of CT-P13 versus inflximab in the context of inflammatory bowel disease [IBD] are still scanty. In the present study, we aimed to compare the biological activities of CT-P13 and infliximab with specific focus on intestinal cells so as to gain insight into the potential biosimilarity of these two agents for treatment of IBD...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28449566/dose-trends-of-aripiprazole-from-2004-to-2014-in-psychiatric-inpatients-in-korea
#6
Young Sup Woo, In Hee Shim, Sang-Yeol Lee, Dae-Bo Lee, Moon-Doo Kim, Young-Eun Jung, Jonghun Lee, Seunghee Won, Duk-In Jon, Won-Myong Bahk
Objective: Although aripiprazole has been widely used to treat various psychiatric disorders, little is known about the adequate dosage for Asian patients in clinical practice. Hence, we evaluated the initial and maximum doses of aripiprazole from 2004 to 2014 to estimate the appropriate dosage for Korean psychiatric inpatients in clinical practice. Methods: In this retrospective study, we reviewed the medical records of patients who were hospitalized in five university hospitals in Korea from March 2004 to December 2014...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449427/trichuris-trichiura-infection-in-north-korean-defector-resulted-in-chronic-abdominal-pain-and-growth-retardation
#7
Jong Bin Kim, Kwang Il Seo, Won Moon
Trichuris trichiura infection is a common helminth infection, which is transmitted via soil, with worldwide distribution, especially in rural areas of developing countries. Occasionally, sporadic cases occur in non-endemic, developed areas due to the widespread of immigration. We experienced a case of Trichuris dysentery syndrome in a young North Korean defector, who had been suffering from chronic abdominal pain for 10 years. He is relatively short and thin compared with his older brother. Unexpectedly, the diagnosis, made by a colonoscopy, revealed numerous, small, white, and gently moving worms at the cecum and ascending colon...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28449425/-the-clinical-significance-of-serum-alpha-fetoprotein-in-diagnosing-hepatocellular-carcinoma-in-a-health-screening-population
#8
Young Sun Ko, Joo Hwan Bae, Dong Hyun Sinn, Geum Youn Gwak, Wonseok Kang, Yong Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Background/Aims: Serum alpha-fetoprotein (AFP) measurement is commonly included in a health check-up program in Korea. However, its benefits remain uncertain. We analyzed whether AFP measurement should be included in a general health check-up program to screen for hepatocellular carcinoma (HCC). Methods: A total of 36,552 adults aged 18 years or older-who participated in a routine health examination including AFP determination between January 2009 and December 2009 at the Health Promotion Center, Samsung Medical Center, South Korea-were analyzed...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28449422/the-effect-of-anti-reflux-therapy-on-patients-diagnosed-with-minor-disorders-of-peristalsis-in-high-resolution-manometry
#9
Joonho Jeong, Sung Eun Kim, Moo In Park, Seun Ja Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Youn Jung Choi, Jun Yeob Lee, Young Dal Lee
Background/Aims: Minor disorders of peristalsis are esophageal motility disorders categorized by the Chicago Classification (CC), version 3.0, which was announced in 2014. This study evaluated the efficacy of anti-reflux therapy in patients with minor peristaltic disorders. Methods: Patients with minor peristaltic disorders in accordance with CC v3.0 were included. We reviewed the medical records of patients with esophageal high-resolution manometry findings, and investigated the demographic and clinical information as well as the medical therapy...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28449187/distinctive-clinical-characteristics-and-favorable-outcomes-in-patients-with-large-granular-lymphocytosis-after-allo-hct-12-years-follow-up-data
#10
Marc Poch Martell, Nada Hamad, Elizabeth Shin, Joon Ho Moon, Sang Kyun Sohn, Jieun Uhm, Fotios V Michelis, Auro Viswabandya, Jeffrey H Lipton, Hans A Messner, Dennis Dong Hwan Kim
An increase in large granular lymphocytes (LGL) is frequently seen in patients following allogeneic hematopoietic cell transplantation (allo-HCT) and it has been associated with better outcomes in some reports. We assessed 826 consecutive patients at our institution with over 12 years of follow-up for the occurrence of LGL lymphocytosis after allo-HCT. The 3 year cumulative incidence of LGL lymphocytosis was 14.5% with a median duration of over 3.5 years. The developmnet of LGL lymphocytosis was strongly correlated with CMV viremia and GVHD...
April 27, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28448573/correction-kidney-dysfunction-and-cerebral-microbleeds-in-neurologically-healthy-adults
#11
Sang Hyuck Kim, Dong Wook Shin, Jae Moon Yun, Ji Eun Lee, Jae-Sung Lim, Be Long Cho, Hyung-Min Kwon, Jin-Ho Park
[This corrects the article DOI: 10.1371/journal.pone.0172210.].
2017: PloS One
https://www.readbyqxmd.com/read/28448392/a-retrospective-study-to-evaluate-the-effect-of-concentration-of-hypertonic-saline-on-efficacy-and-safety-of-epidural-adhesiolysis
#12
Eun Joo Choi, Yong Jae Yoo, Pyung Bok Lee, Yong-Chul Kim, Sang Chul Lee, Jee Youn Moon
BACKGROUND: Percutaneous epidural adhesiolysis (PEA) is a minimally invasive procedure that is performed to relieve low back and/or lower limb pain secondary to adhesions or scarring in the epidural space that is refractory to conservative treatment. The optimal concentration of hypertonic saline might be an important factor in the safety and efficacy of PEA. We evaluated differences in the efficacy and safety of 2 concentrations of hypertonic saline (5% and 10%) used in lumbar PEA at our institutions in a retrospective study...
April 24, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28447440/addition-of-ipragliflozin-to-metformin-treatment-in-korean-patients-with-type-2-diabetes-mellitus-subgroup-analysis-of-a-phase-3-trial
#13
Kyung Wan Min, Bon Jeong Ku, Ji Hyun Lee, Min Seon Kim, Kyu Jeung Ahn, Moon Kyu Lee, Satoshi Kokubo, Satoshi Yoshida, Hyun Ji Cho, Bong Soo Cha
BACKGROUND: This is a subgroup analysis of Korean patients from a phase 3 clinical trial investigating the efficacy and safety of ipragliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin. METHODS: This multicenter, placebo-controlled, double-blind, parallel-group study was carried out between November 2011 and January 2013. Patients entered a 2-week placebo pretreatment period, followed by a 24-week treatment period with either ipragliflozin (50 mg/day) or placebo, while continuing metformin...
April 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28447438/diabetes-camp-as-continuing-education-for-diabetes-self-management-in-middle-aged-and-elderly-people-with-type-2-diabetes-mellitus
#14
So Young Park, Sun Young Kim, Hye Mi Lee, Kyu Yeon Hur, Jae Hyeon Kim, Moon Kyu Lee, Kang Hee Sim, Sang Man Jin
BACKGROUND: Despite the established benefits of diabetes camps for the continuing education of children with type 1 diabetes mellitus, little is known about the long-term metabolic benefits of diabetes camps for middle-aged and elderly people with type 2 diabetes mellitus (T2DM), especially in terms of glycosylated hemoglobin (HbA1c) variability. METHODS: The 1-year mean and variability of HbA1c before and after the diabetes camp was compared between the participants of the diabetes camp (n=57; median age 65 years [range, 50 to 86 years]; median diabetes duration 14 years [range, 1 to 48 years])...
April 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28447437/association-between-blood-mercury-level-and-visceral-adiposity-in-adults
#15
EDITORIAL
Seong Su Moon
No abstract text is available yet for this article.
April 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28447213/discordance-between-physician-and-patient-reported-disease-severity-in-adults-with-atopic-dermatitis-a-us-cross-sectional-survey
#16
Wenhui Wei, Peter Anderson, Abhijit Gadkari, Stuart Blackburn, Rachel Moon, James Piercy, Shashank Shinde, Jorge Gomez, Eric Ghorayeb
BACKGROUND: There is limited understanding of severity rating of atopic dermatitis in clinical practice. OBJECTIVES: To evaluate the agreement between physician- and patient-rated severity of atopic dermatitis. METHODS: Data were collected from the 2014 Adelphi US Atopic Dermatitis Disease Specific Programme, a cross-sectional survey of physicians and their patients with a history of moderate-to-severe atopic dermatitis; patients voluntarily completed a questionnaire...
April 26, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28447116/brain-changes-in-overweight-obese-and-normal-weight-adults-with-type-2-diabetes-mellitus
#17
Sujung Yoon, Hanbyul Cho, Jungyoon Kim, Do-Wan Lee, Geon Ha Kim, Young Sun Hong, Sohyeon Moon, Shinwon Park, Sunho Lee, Suji Lee, Sujin Bae, Donald C Simonson, In Kyoon Lyoo
AIMS/HYPOTHESIS: Overweight and obesity may significantly worsen glycaemic and metabolic control in type 2 diabetes. However, little is known about the effects of overweight and obesity on the brains of people with type 2 diabetes. Here, we investigate whether the presence of overweight or obesity influences the brain and cognitive functions during early stage type 2 diabetes. METHODS: This study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition...
April 27, 2017: Diabetologia
https://www.readbyqxmd.com/read/28446694/social-learning-and-the-demise-of-costly-cooperation-in-humans
#18
Maxwell N Burton-Chellew, Claire El Mouden, Stuart A West
Humans have a sophisticated ability to learn from others, termed social learning, which has allowed us to spread over the planet, construct complex societies, and travel to the moon. It has been hypothesized that social learning has played a pivotal role in making human societies cooperative, by favouring cooperation even when it is not favoured by genetical selection. However, this hypothesis lacks direct experimental testing, and the opposite prediction has also been made, that social learning disfavours cooperation...
April 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28445280/clinical-outcome-after-endoscopic-submucosal-dissection-for-early-gastric-cancer-of-absolute-and-expanded-indication
#19
Ju Seok Kim, Sun Hyung Kang, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
This study evaluated the clinical outcome of endoscopic submucosal dissection (ESD) in minute submucosa (SM) invasion or undifferentiated early gastric cancer (EGC) and analyzed factors related to local recurrence after ESD.We retrospectively reviewed the chart of EGC patients, who underwent ESD at our tertiary hospital between January 2009 and 2015. The patients' characteristics and clinical outcomes were compared among an absolute indication, minute SM invasion, and undifferentiated EGC group.Of 885 total patients, 729 composed the absolute indication group; 65, the differentiated, SM invasion group; and 51, the undifferentiated, confined mucosa group...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444154/infectivity-of-an-asymptomatic-patient-with-middle-east-respiratory-syndrome-coronavirus-infection
#20
Soo-Youn Moon, Jun Seong Son
During the MERS outbreak in Korea, one case of asymptomatic or mild MERS-CoV infection was noted. Eighty-two persons were exposed to the case without protection. They were isolated and RT-PCR and serology for MERS were performed. There was no transmission through an asymptomatic MERS case in this study.
April 22, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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