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https://www.readbyqxmd.com/read/29667763/prospective-randomized-study-of-sexual-function-in-men-taking-dutasteride-for-the-treatment-of-androgenetic-alopecia
#1
Tsen-Fang Tsai, Gwang Seong Choi, Beom Joon Kim, Moon-Bum Kim, Chi Fai Ng, Puja Kochhar, Stacy Jasper, Betsy Brotherton, Barbara Orban, Zrinka Lulic
Treatment with 5α-reductase inhibitors has been associated with sexual adverse events such as impotence (erectile dysfunction) and decreased libido. The primary objective of this study was to evaluate adverse events related to sexual function, based on their frequency, duration, persistence and associated treatment discontinuations, in men treated with dutasteride for androgenetic alopecia. Participants were randomized to receive double-blind dutasteride 0.5 mg or placebo once daily for 24 weeks, followed by open-label dutasteride 0...
April 18, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29667543/assessment-of-parents-guardians-initial-comprehension-and-1-day-recall-of-elements-of-informed-consent-within-a-mozambican-study-of-pediatric-bacteremia
#2
Ezequiel B Ossemane, Troy D Moon, Jahit Sacarlal, Esperança Sevene, Darlene Kenga, Wu Gong, Elizabeth Heitman
Participants' understanding of key elements of a research protocol is essential to their ethical enrollment in the study. Ongoing participation should be based on continued comprehension and consent, which presumes a high degree of recall. Many obstacles can prevent full understanding of information about the research protocol. This study's aim was to evaluate the comprehension and 1-day recall of the elements of informed consent by the parents/guardians of children enrolled in a clinical study in Mozambique...
April 1, 2018: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/29666796/plc%C3%AE-induced-ca-2-oscillations-in-mouse-eggs-involve-a-positive-feedback-cycle-of-ca-2-induced-insp-3-formation-from-cytoplasmic-pip-2
#3
Jessica R Sanders, Bethany Ashley, Anna Moon, Thomas E Woolley, Karl Swann
Egg activation at fertilization in mammalian eggs is caused by a series of transient increases in the cytosolic free Ca2+ concentration, referred to as Ca2+ oscillations. It is widely accepted that these Ca2+ oscillations are initiated by a sperm derived phospholipase C isoform, PLCζ that hydrolyses its substrate PIP2 to produce the Ca2+ releasing messenger InsP3 . However, it is not clear whether PLCζ induced InsP3 formation is periodic or monotonic, and whether the PIP2 source for generating InsP3 from PLCζ is in the plasma membrane or the cytoplasm...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29666368/a-large-planetary-body-inferred-from-diamond-inclusions-in-a-ureilite-meteorite
#4
Farhang Nabiei, James Badro, Teresa Dennenwaldt, Emad Oveisi, Marco Cantoni, Cécile Hébert, Ahmed El Goresy, Jean-Alix Barrat, Philippe Gillet
Planetary formation models show that terrestrial planets are formed by the accretion of tens of Moon- to Mars-sized planetary embryos through energetic giant impacts. However, relics of these large proto-planets are yet to be found. Ureilites are one of the main families of achondritic meteorites and their parent body is believed to have been catastrophically disrupted by an impact during the first 10 million years of the solar system. Here we studied a section of the Almahata Sitta ureilite using transmission electron microscopy, where large diamonds were formed at high pressure inside the parent body...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29666179/increasing-trends-in-hospital-care-burden-of-atrial-fibrillation-in-korea-2006-through-2015
#5
Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
OBJECTIVE: Temporal changes in the healthcare burden of atrial fibrillation (AF) are less well known in rapidly ageing Asian countries. We examined trends in hospitalisations, costs, treatment patterns and outcomes related to AF in Korea. METHODS: Using the National Health Insurance Service (NHIS) database involving the entire adult Korean population (n=41 701 269 in 2015), we analysed a nationwide AF cohort representing 931 138 patients with AF. We studied all hospitalisations due to AF from 2006 to 2015...
April 17, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29665674/hippo-signaling-circuit-and-divergent-tissue-growth-in-mammalian-eye
#6
Kyeong Hwan Moon, Jin Woo Kim
Vertebrate organ development is accompanied by demarcation of tissue compartments, which grow coordinately with their neighbors. Hence, perturbing the coordinative growth of neighboring tissue compartments frequently results in organ malformation. The growth of tissue compartments is regulated by multiple intercellular and intracellular signaling pathways, including the Hippo signaling pathway that limits the growth of various organs. In the optic neuroepithelial continuum, which is partitioned into the retina, retinal pigment epithelium (RPE) and ciliary margin (CM) during eye development, the Hippo signaling activity operates differentially, as it does in many tissues...
April 11, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29665628/effect-of-topical-propolis-on-wound-healing-process-after-tonsillectomy-randomized-controlled-study
#7
Jeong Hwan Moon, Min Young Lee, Young-Jun Chung, Chung-Ku Rhee, Sang Joon Lee
Objectives: The post-tonsillectomy pain and post-tonsillectomy hemorrhage are the two main problems after tonsillectomy. The aim of this study was to investigate the beneficial effects of water soluble ethanol extract propolis on post-tonsillectomy patient. Methods: One hundred and thirty patients who underwent tonsillectomy or adenotonsillectomy were randomly divided into the control and propolis groups, each including 65 patients. The propolis group was applied with propolis orally immediately after surgery and by gargle...
December 28, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29665206/defect-free-highly-uniform-washable-transparent-electrodes-induced-by-selective-light-irradiation
#8
Zhaoyang Zhong, Kyoohee Woo, Inhyuk Kim, Hyuntae Kim, Pyeongsam Ko, Dongwoo Kang, Sin Kwon, Hyunchang Kim, Hongseok Youn, Jooho Moon
A simple route to fabricate defect-free Ag-nanoparticle-carbon-nanotube composite-based high-resolution mesh flexible transparent conducting electrodes (FTCEs) is explored. In the selective photonic sintering-based patterning process, a highly soft rubber or thin plastic substrate is utilized to achieve close and uniform contact between the composite layer and photomask, with which uniform light irradiation can be obtained with diminished light diffraction. This well-controlled process results in developing a fine and uniform mesh pattern (≈12 μm)...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29665013/planhab-hypoxia-does-not-worsen-the-impairment-of-skeletal-muscle-oxidative-function-induced-by-bed-rest-alone
#9
Desy Salvadego, Michail E Keramidas, Roger Kölegård, Lorenza Brocca, Stefano Lazzer, Irene Mavelli, Jörn Rittweger, Ola Eiken, Igor B Mekjavic, Bruno Grassi
KEY POINTS: Superposition of hypoxia on 21 day bed rest did not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone. A significant impairment of maximal oxidative performance was identified downstream of cardiovascular O2 delivery, involving both the intramuscular matching between O2 supply and utilization and mitochondrial respiration. These chronic adaptations appear to be relevant in terms of exposure to spaceflights and reduced gravity habitats (Moon or Mars), as characterized by low gravity and hypoxia, in patients with chronic diseases characterized by hypomobility/immobility and hypoxia, as well as in ageing...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29664949/correction-accuracy-of-a-screening-tool-for-medication-adherence-a-systematic-review-and-meta-analysis-of-the-morisky-medication-adherence-scale-8
#10
Sun Jae Moon, Weon-Young Lee, Jin Seub Hwang, Yeon Pyo Hong, Donald E Morisky
[This corrects the article DOI: 10.1371/journal.pone.0187139.].
2018: PloS One
https://www.readbyqxmd.com/read/29664377/characterization-of-clinical-isolates-of-bartonella-henselae-strains-south-korea
#11
Hea Yoon Kwon, Young Kyoung Park, Sun Myoung Lee, Ji Hyeon Baek, Jae-Seung Kang, Moon-Hyun Chung, Eun Ji Kim, Jin-Soo Lee
Bartonella henselae, a gram-negative bacterium, is a common causative agent of zoonotic infections. We report 5 culture-proven cases of B. henselae infection in South Korea. By alignment of the 16S rRNA sequences and multilocus sequencing typing analysis, we identified all isolates as B. henselae Houston-1 strain, which belongs to sequence type 1.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29663867/coiled-coil-and-leucine-rich-repeat-domain-of-the-potyvirus-resistance-protein-pvr4-has-distinct-role-in-signaling-and-pathogen-recognition
#12
Saet-Byul Kim, Hye-Young Lee, Eun-Hye Choi, Eunsook Park, Jihyun Kim, Ki-Beom Moon, Hyun-Soon Kim, Doil Choi
The pepper Pvr4 encoding coiled-coil (CC) nucleotide-binding (NB) leucine-rich repeat (LRR) protein (CC-NLR) confer hypersensitive resistance (HR) to potyviruses, including Pepper mottle virus (PepMoV) by recognizing the viral avirulence protein, NIb. To figure out the Pvr4-mediated HR mechanism, we analyzed the signaling component genes and structure-function relationships of Pvr4 using chimeras and deletion mutants in Nicotiana benthamiana. Molecular chaperone components including HSP90, SGT1 and RAR1 were required, while plant hormones and mitogen-activated protein (MAP) kinase signaling components had little effect on Pvr4-NIb-mediated HR cell death...
April 17, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29663701/efficacy-and-safety-of-retinaldehyde-0-1-and-0-05-creams-used-to-treat-photoaged-skin-a-randomized-double-blind-controlled-trial
#13
Hyuck Sun Kwon, Ji Hae Lee, Gyong Moon Kim, Jung Min Bae
BACKGROUND: Although topical retinoic acid effectively restores photoaged skin, the associated irritation limits the utility of the material. Retinaldehyde (RAL) is the natural precursor of retinoic acid and can also be used to treat photoaged skin; the safety profile is good. AIMS: To evaluate the efficacy and safety of new anti-aging creams containing RAL at 0.1% and 0.05% used to treat photoaged skin. PATIENTS AND METHODS: We enrolled 40 female Korean volunteers who applied RAL 0...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29663332/enhanced-isobutanol-production-from-acetate-by-combinatorial-overexpression-of-acetyl-coa-synthetase-and-anaplerotic-enzymes-in-engineered-escherichia-coli
#14
Hun-Suk Song, Hyung-Min Seo, Jong-Min Jeon, Yu-Mi Moon, Ju Won Hong, Yoon Gi Hong, Shashi Kant Bhatia, Jungoh Ahn, Hongweon Lee, Wooseong Kim, Yong-Cheol Park, Kwon Young Choi, Yun-Gon Kim, Yung-Hun Yang
Acetic acid is an abundant material that can be used as a carbon source by microorganisms. Despite its abundance, its toxicity and low energy content make it hard to utilize as a sole carbon source for biochemical production. To increase acetate utilization and isobutanol production with engineered Escherichia coli, the feasibility of utilizing acetate and metabolic engineering was investigated. The expression of acs, pckA, and maeB increased isobutanol production by up to 26%, and the addition of TCA cycle intermediates indicated that the intermediates can enhance isobutanol production...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29662869/a-case-of-adult-t-cell-leukemia-lymphoma-in-korea
#15
Yong-Moon Lee, Jin-Man Kim
No abstract text is available yet for this article.
March 2018: Blood Research
https://www.readbyqxmd.com/read/29662562/the-predictive-values-of-lesion-size-f-18-fdg-avidity-and-i-131-avidity-for-the-clinical-outcome-of-i-131-treatment-in-patients-with-metastatic-differentiated-thyroid-carcinoma-only-in-the-lung
#16
Joon Ho Choi, Byung Hyun Byun, Ilhan Lim, Hansol Moon, Jihyun Park, Kyoung Jin Chang, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
Purpose: We aimed to evaluate the prognostic values of radiography, F-18 FDG PET, and I-131 whole body scans in patients with lung-only metastasis from differentiated thyroid carcinoma (DTC). Methods: Between 1998 and 2013, we included 31 patients (F: 26, M: 5) with lung-only metastasis from DTC who had been treated with I-131 and underwent PET. Lung metastasis was categorized according to the size (macronodular ≥1.0 cm vs. micronodular <1.0 cm), FDG avidity (avid vs...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662144/selection-of-stable-reference-genes-for-rt-qpcr-in-rhodococcus-opacus-pd630
#17
Drew M DeLorenzo, Tae Seok Moon
Rhodococcus opacus PD630 is a gram-positive bacterium with promising attributes for the conversion of lignin into valuable fuels and chemicals. To develop an organism as a cellular factory, it is necessary to have a deep understanding of its metabolism and any heterologous pathways being expressed. For the purpose of quantifying gene transcription, reverse transcription quantitative PCR (RT-qPCR) is the gold standard due to its sensitivity and reproducibility. However, RT-qPCR requires the use of reference genes whose expression is stable across distinct growth or treatment conditions to normalize the results...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661870/amikacin-inhalation-as-salvage-therapy-for-refractory-nontuberculous-mycobacterial-lung-disease
#18
Byung Woo Jhun, Bumhee Yang, Seong Mi Moon, Hyun Lee, Hye Yun Park, Kyeongman Jeon, O Jung Kwon, Jungmin Ahn, Il Joon Moon, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Although guidelines recommend amikacin (AMK) inhalation therapy for difficult-to-treat nontuberculous mycobacterial lung disease (NTM-LD), data are limited regarding the safety and clinical efficacy of this salvage therapy. We retrospectively evaluated treatment outcomes of 77 patients with refractory NTM-LD caused by Mycobacterium abscessus complex (MABC) or M. avium complex (MAC) who initiated AMK inhalation therapy between February 2015 and June 2016. MABC was the most common etiology (n = 48, 62%), followed by MAC (n = 20, 26%) and mixed infections (n = 9, 12%)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29661543/lunar-and-climatic-effects-on-boar-ejaculate-traits
#19
Josué Chinchilla-Vargas, Karl Kerns, Max F Rothschild
There is evidence that phases of the moon affect wild animal behaviors including reproduction. There is, however, little evidence of moon phase effects on domestic livestock reproduction. This study investigated the effects of moon phase and climatic variables on boar ejaculate traits. Records of 4149 semen collections from boars of nine different breeds at one boar stud were used. The response variables were volume of ejaculate, concentration of sperm in the ejaculate, and number of doses obtained per ejaculate...
April 6, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29661264/outbreak-of-hepatitis-a-virus-infection-among-adult-patients-of-a-mental-hospital-los-angeles-county-2017
#20
Curtis Croker, Susan Hathaway, Amy Marutani, Margilane Hernandez, Crystal Cadavid, Shobita Rajagopalan, Bessie Hwang, Moon Kim
No abstract text is available yet for this article.
April 17, 2018: Infection Control and Hospital Epidemiology
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