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https://www.readbyqxmd.com/read/29040626/a-dose-response-meta-analysis-of-chronic-arsenic-exposure-and-incident-cardiovascular-disease
#1
Katherine A Moon, Shilpi Oberoi, Aaron Barchowsky, Yu Chen, Eliseo Guallar, Keeve E Nachman, Mahfuzar Rahman, Nazmul Sohel, Daniela D'Ippoliti, Timothy J Wade, Katherine A James, Shohreh F Farzan, Margaret R Karagas, Habibul Ahsan, Ana Navas-Acien
Background: Consistent evidence at high levels of water arsenic (≥100 µg/l), and growing evidence at low-moderate levels (<100 µg/l), support a link with cardiovascular disease (CVD). The shape of the dose-response across low-moderate and high levels of arsenic in drinking water is uncertain and critical for risk assessment. Methods: We conducted a systematic review of general population epidemiological studies of arsenic and incident clinical CVD (all CVD, coronary heart disease (CHD) and stroke) with three or more exposure categories...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29037026/treatment-outcomes-of-extended-field-radiation-therapy-for-thoracic-superficial-esophageal-cancer
#2
Doo Yeul Lee, Sung Ho Moon, Kwan Ho Cho, Tae Hyun Kim, Moon Soo Kim, Jong Yeul Lee, Yang-Gun Suh
PURPOSE: To evaluate the efficacy and safety of extended-field radiation therapy for patients with thoracic superficial esophageal cancer (SEC). MATERIALS AND METHODS: From May 2007 to October 2016, a total of 24 patients with thoracic SEC (T1a and T1b) who underwent definitive radiotherapy and were analyzed retrospectively. The median total radiotherapy dose was 64 Gy (range, 54 to 66 Gy) in conventional fractionation. All 24 patients received radiotherapy to whole thoracic esophagus and 23 patients received elective nodal irradiation...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29037009/early-statins-after-intravenous-or-endovascular-recanalization-is-beneficial-regardless-of-timing-intensity-and-stroke-mechanism
#3
Han-Gil Jeong, Beom Joon Kim, Mi Hwa Yang, Moon-Ku Han, Hee-Joon Bae
No abstract text is available yet for this article.
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29036757/a-case-of-medullary-infarction-presented-initial-symptoms-similar-to-meniere-s-disease
#4
Jang Hee Park, Dong Hyun Kim, Jae Moon Sung, Chang Woo Kim
Fluctuating hearing loss and vertigo are the typical presentations of Meniere's disease. However, it is unusual that fluctuating hearing loss and vertigo are caused by vertebral artery occlusion or cerebral infarction. Here, we described the case of a 54-year-old male patient with hypertension and diabetes mellitus who presented with fluctuating hearing loss in his left ear and severe whirling-type dizziness without associated neurological signs or symptoms. Temporal magnetic resonance imaging (MRI) was normal...
October 17, 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29036712/comparison-of-cosmic-ray-environments-on-earth-moon-mars-and-in-spacecarft-using-phits
#5
Tatsuhiko Sato, Aiko Nagamatsu, Haruka Ueno, Ryuho Kataoka, Shoko Miyake, Kazuo Takeda, Koji Niita
Estimation of cosmic-ray doses is of great importance not only in aircrew and astronaut dosimetry but also in evaluation of background radiation exposure to public. We therefore calculated the cosmic-ray doses on Earth, Moon and Mars as well as inside spacecraft, using Particle and Heavy Ion Transport code System PHITS. The same cosmic-ray models and dose conversion coefficients were employed in the calculation to properly compare between the simulation results for different environments. It is quantitatively confirmed that the thickness of physical shielding including the atmosphere and soil of the planets is the most important parameter to determine the cosmic-ray doses and their dominant contributors...
September 29, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036407/prognostic-value-of-the-circumferential-resection-margin-and-its-definitions-in-esophageal-cancer-patients-after-neoadjuvant-chemoradiotherapy
#6
L Depypere, J Moons, T Lerut, G De Hertogh, C Peters, X Sagaert, W Coosemans, H Van Veer, P Nafteux
The accepted importance of a positive circumferential resection margin (CRM) (defined as R1 in the TNM classification) is based on histopathology of the resection specimen obtained after primary surgery in esophageal cancer patients. The aim of this study is to look for the prognostic value of CRM after neoadjuvant chemoradiotherapy and to compare the clinical significance of a histologically CRM < 1 mm from the cut margin (Royal College of Pathologists definition of R1) to a positive cut margin (College of American Pathologists definition of R1) and to ≥1 mm margin (R0) resections in patients with ypT3-esophageal tumors after neoadjuvant chemoradiotherapy...
September 27, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036083/continuous-digital-zooming-using-local-self-similarity-based-super-resolution-for-an-asymmetric-dual-camera-system
#7
Byeongho Moon, Soohwan Yu, Seungyong Ko, Seonhee Park, Joonki Paik
This paper presents a digital zooming method using a super-resolution (SR) algorithm based on the local self-similarity between the wide- and tele-view images acquired by an asymmetric dual camera system. The proposed SR algorithm consists of four steps: (i) registration of an optically zoomed image to the wide-view image, (ii) restoration of the central region of the zoomed wide-view image, (iii) restoration of the boundary region of the zoomed wide-view image, and (iv) fusion of the results from steps (ii) and (iii)...
June 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035895/a-large-anterior-mediastinal-mass
#8
Jonathan Stubblefield, Tiffany Moon, James Griffin
No abstract text is available yet for this article.
October 16, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29035838/effect-of-two-treatment-protocols-for-ketosis-on-the-resolution-postpartum-health-milk-yield-and-reproductive-outcomes-of-dairy-cows
#9
Jae-Kwan Jeong, In-Soo Choi, Sung-Ho Moon, Soo-Chan Lee, Hyun-Gu Kang, Young-Hun Jung, Soo-Bong Park, Ill-Hwa Kim
We determined the effect of ketosis treatment with propylene glycol (PG) or PG plus l-carnitine and methionine (Metabolase(®), Fatro, Bologna, Italy) on the resolution, postpartum health, milk yield, and reproductive performances of dairy cows. Blood from 475 Holstein cows was collected weekly until 4 weeks after calving to measure blood β-hydroxybutyrate (BHBA) concentrations. Cows with blood BHBA concentration ≥1.2 mmol/L were diagnosed with ketosis and were enrolled. One hundred and fifty cows diagnosed with ketosis were randomly assigned to three treatment groups (Day 0): (1) PG (300 g, PO) for 3 days (PG group, n = 50), (2) PG (300 g, PO) plus l-carnitine (1...
September 25, 2017: Theriogenology
https://www.readbyqxmd.com/read/29035736/mechanotransduction-of-human-pluripotent-stem-cells-cultivated-on-tunable-cell-derived-extracellular-matrix
#10
In Gul Kim, Chang-Hyun Gil, Joseph Seo, Soon-Jung Park, Ramesh Subbiah, Taek-Hee Jung, Jong Soo Kim, Young-Hoon Jeong, Hyung-Min Chung, Jong Ho Lee, Man Ryul Lee, Sung-Hwan Moon, Kwideok Park
Cell-derived matrices (CDM) are becoming an attractive alternative to conventional biological scaffolding platforms due to its unique ability to closely recapitulate a native extracellular matrix (ECM) de novo. Although cell-substrate interactions are recognized to be principal in regulating stem cell behavior, very few studies have documented the acclimation of human pluripotent stem cells (hPSCs) on pristine and altered cell-derived matrices. Here, we investigate crosslink-induced mechanotransduction of hPSCs cultivated on decellularized fibroblast-derived matrices (FDM) to explore cell adhesion, growth, migration, and pluripotency in various biological landscapes...
October 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/29035732/development-and-validation-of-an-automated-delirium-risk-assessment-system-auto-delras-implemented-in-the-electronic-health-record-system
#11
Kyoung-Ja Moon, Yinji Jin, Taixian Jin, Sun-Mi Lee
BACKGROUND: A key component of the delirium management is prevention and early detection. OBJECTIVE: To develop an automated delirium risk assessment system (Auto-DelRAS) that automatically alerts health care providers of an intensive care unit (ICU) patient's delirium risk based only on data collected in an electronic health record (EHR) system, and to evaluate the clinical validity of this system. DESIGN: Cohort and system development designs were used...
September 23, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29035500/reliable-multi-state-data-storage-with-low-power-consumption-by-selective-oxidation-of-pyramid-structured-resistive-memory
#12
Youngjin Kim, Hanhyeong Choi, Hyun S Park, Moon Sung Kang, Keun-Young Shin, Sang-Soo Lee, Jong Hyuk Park
Multilevel data storage using resistive random access memory (RRAM) has attracted significant attention for addressing the challenges associated with the rapid advances in information technologies. However, it is still difficult to secure reliable multilevel resistive switching of RRAM due to the stochastic and multiple formation of conductive filaments (CFs). Herein, we demonstrate that a single CF, derived from selective oxidation by a structured Cu active electrode, can solve the reliability issue. High-quality pyramidal Cu electrodes with a sharp tip are prepared via the template-stripping method...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29034928/boosting-up-the-electrical-performance-of-low-grade-pedot-pss-by-optimizing-non-ionic-surfactants
#13
Sunghee Kim, Sunghwan Cho, Su Jeong Lee, Gilwoon Lee, Minsik Kong, Sungmin Moon, Jae-Min Myoung, Unyong Jeong
Although PEDOT:PSS has already been applied to various electronic devices, commercialized PEDOT:PSS products having high conductivity are expensive, which is a considerable burden on device manufacturing. In this study, we optimize non-ionic surfactants mixed in a PEDOT:PSS solution to upgrade a low-grade product of low conductivity to the level of a high-grade product of high conductivity. This study systematically investigates the phase diagram, morphology, conductivity, and mechanical stability of the PEDOT:PSS films according to the hydrophilicity of non-ionic surfactants...
October 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29033867/sweeping-the-floor-or-putting-a-man-on-the-moon-how-to-define-and-measure-meaningful-work
#14
Jitske M C Both-Nwabuwe, Maria T M Dijkstra, Bianca Beersma
Meaningful work is integral to well-being and a flourishing life. The construct of "meaningful work" is, however, consistently affected by conceptual ambiguity. Although there is substantial support for arguments to maintain the status of conceptual ambiguity, we make a case for the benefits of having consensus on a definition and scale of meaningful work in the context of paid work. The objective of this article, therefore, was twofold. Firstly, we wanted to develop a more integrative definition of meaningful work...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29033567/nanoparticles-for-the-treatment-of-liver-fibrosis
#15
REVIEW
Suchithra Poilil Surendran, Reju George Thomas, Myeong Ju Moon, Yong Yeon Jeong
Chronic liver diseases represent a global health problem due to their high prevalence worldwide and the limited available curative treatment options. They can result from various causes, both infectious and noninfectious diseases. The application of nanoparticle (NP) systems has emerged as a rapidly evolving area of interest for the safe delivery of various drugs and nucleic acids for chronic liver diseases. This review presents the pathogenesis, diagnosis and the emerging nanoparticulate systems used in the treatment of chronic liver diseases caused by liver fibrosis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29033353/melanocyte-stem-cell-activation-and-translocation-initiate-cutaneous-melanoma-in-response-to-uv-exposure
#16
Hyeongsun Moon, Leanne R Donahue, Eunju Choi, Philip O Scumpia, William E Lowry, Jennifer K Grenier, Jerry Zhu, Andrew C White
Melanoma is one of the deadliest cancers, yet the cells of origin and mechanisms of tumor initiation remain unclear. The majority of melanomas emerge from clear skin without a precursor lesion, but it is unknown whether these melanomas can arise from melanocyte stem cells (MCSCs). Here we employ mouse models to define the role of MCSCs as melanoma cells of origin, demonstrate that MCSC quiescence acts as a tumor suppressor, and identify the extrinsic environmental and molecular factors required for the critical early steps of melanoma initiation...
October 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29033190/3d-modelling-of-radical-prostatectomy-specimens-developing-a-method-to-quantify-tumor-morphometry-for-prostate-cancer-risk-prediction
#17
Marcus C Hovens, Kevin Lo, Michael Kerger, John Pedersen, Timothy Nottle, Natalie Kurganovs, Andrew Ryan, Justin S Peters, Daniel Moon, Anthony J Costello, Niall M Corcoran, Matthew K H Hong
Prostate cancer displays a wide spectrum of clinical behaviour from biological indolence to rapidly lethal disease, but we remain unable to accurately predict an individual tumor's future clinical course at an early curable stage. Beyond basic dimensions and volume calculations, tumor morphometry is an area that has received little attention, as it requires the analysis of the prostate gland and tumor foci in three-dimensions. Previous efforts to generate three-dimensional prostate models have required specialised graphics units and focused on the spatial distribution of tumors for optimisation of biopsy strategies rather than to generate novel morphometric variables such as tumor surface area...
September 27, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29033094/necessity-of-axillary-scanning-after-negative-finding-on-both-mammography-and-subsequent-breast-ultrasound
#18
Inyoung Youn, Jung Hyun Yoon, Ji Hyun Youk, Hee Jung Moon, Min Jung Kim, Eun-Kyung Kim, Jai Kyung You
The purpose of our study was to assess the cancer detection rate and positive predictive value (PPV) for incidentally detected abnormal axillary lymph nodes with negative mammography and subsequent breast ultrasound (US). We included 7039 screened patients (mean age, 52 y) from January 2012 to March 2015 with negative mammography and subsequent breast US results. In two patients with positive lymph nodes, neither were from breast malignancy. The calculated cancer detection rate, PPV for biopsy and axillary biopsy rate was 0...
October 12, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29032941/ferritin-iron-regulators-pcbp1-and-ncoa4-respond-to-cellular-iron-status-in-developing-red-cells
#19
Moon-Suhn Ryu, Kari A Duck, Caroline C Philpott
Developing red blood cells exhibit multiple, redundant systems for regulating and coordinating the uptake of iron, the synthesis of heme, and the formation of hemoglobin during terminal differentiation. We recently described the roles of poly rC-binding protein (PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and iron release...
September 28, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/29032669/xp11-2-translocation-renal-cell-carcinoma-in-the-autosomal-dominant-polycystic-kidney-disease-patient-with-preserved-renal-function
#20
Hyuk Huh, Hyung Ah Jo, YongJin Yi, Seung Hyup Kim, Kyung Chul Moon, Curie Ahn, Hayne Cho Park
No abstract text is available yet for this article.
October 17, 2017: Korean Journal of Internal Medicine
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