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https://www.readbyqxmd.com/read/29667777/induced-pluripotent-stem-cell-derived-conditional-medium-promotes-leydig-cell-anti-apoptosis-and-proliferation-via-autophagy-and-wnt-%C3%AE-catenin-pathway
#1
Xiaoling Guo, Yong Chen, Tingting Hong, Xianwu Chen, Yue Duan, Chao Li, Renshan Ge
Leydig cell transplantation is a better alternative in the treatment of androgen-deficient males. The main purpose of this study was to investigate the effects of induced pluripotent stem cell-derived conditioned medium (iPS-CM) on the anti-apoptosis, proliferation and function of immature Leydig cells (ILCs), and illuminate the underlying mechanisms. ILCs were exposed to 200 μmol/L hydrogen peroxide (H2 O2 ) for 24 hours with or without iPS-CM treatments. Cell apoptosis was detected by flow cytometric analysis...
April 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29667499/breaking-the-silence-and-other-prevention-lessons-from-the-opioid-epidemic
#2
Paul E Terry
The goal of this editorial is to equip readers with opioid education resources that enable you to role model what it looks like to speak out about addiction. How are we doing as a profession speaking up about addiction? Stigma is commanded by a deep irony: where peer pressure is what likely keeps us quiet, peer support is what enables us to speak up. The "#MeToo" movement is an extraordinary example of the inertia needed to break open a taboo topic. From Hollywood celebrities to US women's gymnastics stars, it was clear that as more women spoke up about sexual harassment, well, the more women spoke out...
May 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29666544/efficiency-of-selected-food-ingredients-on-protein-efficiency-ratio-glycemic-index-and-in-vitro-digestive-properties
#3
M B Anusha, Naveen Shivanna, G Phani Kumar, K R Anilakumar
The human body on exposure to high-altitude, undergoes many physiological challenges. The cardiopulmonary reserves are favoured against the digestive system. Hence, the efficiency of digestion is compromised to a great extent, which leads to anorexia, hypophagia, epigastralgia, dyspepsia, nausea, and peptic ulcers. The present study was focused on in vitro digestive influence of selected food ingredients viz. cardamom, carom, cumin, coriander, fennel, fenugreek, ginger, pepper, star anise, turmeric, papaya, orange, pineapple, liquorice, valerian, and tarragon on the activities of digestive enzymes of rat pancreas, duodenum, and small intestine...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29665336/degradable-3d-printed-hydrogels-based-on-star-shaped-copolypeptides
#4
Robert Murphy, David P Walsh, Charles A Hamilton, Sally-Ann Cryan, Marc In Het Panhuis, Andreas Heise
We present a star copolypeptide based hydrogel ink capable of structural microfabrication using 3D extrusion printing. The material comprises an amphiphilic block copolymer structure of poly(benzyl-L-glutamate-b-L-valine), which spontaneously form hydrogels through hydrophobic interaction. The chemical design allows the bulk phase of the hydrogel to remain intact after application of shear due to its self-recovery behavior. It is demonstrated that the composition of the materials is ideally suited for 3D printing; with scaffolds capable of maintaining structural cohesion after extrusion...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29663431/a-novel-verification-method-using-a-plastic-scintillator-imagining-system-for-assessment-of-gantry-sag-in-radiotherapy
#5
Masato Tsuneda, Teiji Nishio, Akito Saito, Sodai Tanaka, Tatsuhiko Suzuki, Daisuke Kawahara, Keiichiro Matsushita, Aya Nishio, Shuichi Ozawa, Kumiko Karasawa, Yasushi Nagata
PURPOSE: High accuracy of the beam-irradiated position is required for high-precision radiation therapy such as stereotactic body radiation therapy (SBRT), volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT). Users generally perform the verification of the mechanical and radiation isocenters using the star shot test and the Winston Lutz test that allow evaluation of the displacement at the isocenter. However, these methods are unable to evaluate directly and quantitatively the sagging angle that is caused by the weight of the gantry itself along the gantry rotation axis...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29663000/structure-formation-in-soft-nanocolloids-liquid-drop-model
#6
A-K Doukas, C N Likos, P Ziherl
Using a model where soft nanocolloids such as spherical polymer brushes and star polymers are viewed as compressible liquid drops, we theoretically explore contact interactions between such particles. By numerically minimizing the phenomenological free energy consisting of bulk and surface terms, we find that at small deformations the drop-drop interaction is pairwise additive and described by a power law. We also propose a theory to describe the small-deformation regime, and the agreement is very good at all drop compressibilities...
April 17, 2018: Soft Matter
https://www.readbyqxmd.com/read/29662842/antioxidative-and-cholesterol-lowering-effects-of-lemon-essential-oil-in-hypercholesterolemia-induced-rabbits
#7
Hyunjoo Lee, Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
The cholesterol-lowering and anti-atherogenic effects of lemon essential oil (LEO) were investigated and compared with the effects of limonene. Owing to their volatility, both LEO and limonene were microencapsulated before preparation of the diet (20%, w/w). Hypercholesterolemia-induced rabbits were divided into 3 groups based on plasma total cholesterol (TC) levels and fed coating matrix (control group), LEO (LEO group), or limonene (Limonene group) for 8 weeks. LEO dose-dependently inhibited low-density lipoprotein oxidation in vitro ...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29661981/high-energy-astrophysics-and-the-search-for-sources-of-gravitational-waves
#8
P T O'Brien, P Evans
The dawn of the gravitational-wave (GW) era has sparked a greatly renewed interest into possible links between sources of high-energy radiation and GWs. The most luminous high-energy sources-gamma-ray bursts (GRBs)-have long been considered as very likely sources of GWs, particularly from short-duration GRBs, which are thought to originate from the merger of two compact objects such as binary neutron stars and a neutron star-black hole binary. In this paper, we discuss: (i) the high-energy emission from short-duration GRBs; (ii) what other sources of high-energy radiation may be observed from binary mergers; and (iii) how searches for high-energy electromagnetic counterparts to GW events are performed with current space facilities...
May 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29661980/the-prospects-of-pulsar-timing-with-new-generation-radio-telescopes-and-the-square-kilometre-array
#9
REVIEW
B W Stappers, E F Keane, M Kramer, A Possenti, I H Stairs
Pulsars are highly magnetized and rapidly rotating neutron stars. As they spin, the lighthouse-like beam of radio emission from their magnetic poles sweeps across the Earth with a regularity approaching that of the most precise clocks known. This precision combined with the extreme environments in which they are found, often in compact orbits with other neutron stars and white dwarfs, makes them excellent tools for studying gravity. Present and near-future pulsar surveys, especially those using the new generation of telescopes, will find more extreme binary systems and pulsars that are more precise 'clocks'...
May 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29661975/gravitational-waves-from-neutron-stars-and-asteroseismology
#10
Wynn C G Ho
Neutron stars are born in the supernova explosion of massive stars. Neutron stars rotate as stably as atomic clocks and possess densities exceeding that of atomic nuclei and magnetic fields millions to billions of times stronger than those created in laboratories on the Earth. The physical properties of neutron stars are determined by many areas of fundamental physics, and detection of gravitational waves can provide invaluable insights into our understanding of these areas. Here, we describe some of the physics and astrophysics of neutron stars and how traditional electromagnetic wave observations provide clues to the sorts of gravitational waves we expect from these stars...
May 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29661972/gravitational-wave-astronomy-delivering-on-the-promises
#11
B F Schutz
Now that LIGO and Virgo have begun to detect gravitational-wave events with regularity, the field of gravitational-wave astronomy is beginning to realize its promise. Binary black holes and, very recently, binary neutron stars have been observed, and we are already learning much from them. The future, with improved sensitivity, more detectors and detectors like LISA in different frequency bands, has even more promise to open a completely hidden side of the Universe to our exploration.This article is part of a discussion meeting issue 'The promises of gravitational-wave astronomy'...
May 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29660344/hyperhomocysteinemia-and-hyperandrogenemia-share-pcsk9-ldlr-pathway-to-disrupt-lipid-homeostasis-in-pcos
#12
Kalyani Mondal, Pratip Chakraborty, S N Kabir
Women with polycystic ovary syndrome (PCOS) are at increased risk of cardiovascular diseases (CVD); however, the independent role of PCOS in the incident CVD remains unknown. There are reports that hyperhomocysteinemia (HHcy), a potential cause of CVD, is frequently associated with PCOS. The present study investigates the independent attributes of hyperandrogenemia (HA), the integral associate of PCOS, and HHcy in causing atherogenic dyslipidemia. Twenty-five-day old rats were treated with homocysteine (Hcy) at 50 mg/kg/day dose level for 12 weeks...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29660255/trans-life-cycle-acclimation-to-experimental-ocean-acidification-affects-gastric-ph-homeostasis-and-larval-recruitment-in-the-sea-star-asterias-rubens
#13
Marian Y Hu, Etienne Lein, Markus Bleich, Frank Melzner, Meike Stumpp
AIM: Experimental simulation of near-future ocean acidification (OA) has been demonstrated to affect growth and development of echinoderm larval stages through energy allocation towards ion and pH compensatory processes. To date, it remains largely unknown how major pH regulatory systems and their energetics are affected by trans-generational exposure to near-future acidification levels. METHODS: Here we used the common sea star Asterias rubens in a reciprocal transplant experiment comprising different combinations of OA scenarios, in order to study trans-generational plasticity using morphological and physiological endpoints...
April 16, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29657605/meta-analysis-of-the-efficacy-and-safety-of-pantoprazole-in-the-treatment-and-symptom-relief-of-patients-with-gastroesophageal-reflux-disease-pan-star
#14
Andrzej Dabrowski, Borut Štabuc, Leonid Lazebnik
Introduction: Proton pump inhibitors therapy success in the treatment of gastroesophageal reflux disease (GERD) is a difficult task because the extent of mucosal damage has no relation with the severity of the symptoms. Aim: To establish the efficacy of pantoprazole treatment in patients with erosive reflux disease (ERD) and in those with non-erosive reflux disease (NERD), by assessing symptom relief and quality of life. Treatment duration and adverse events associated with pantoprazole treatment were analysed...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29657452/impact-of-various-foot-arches-on-dynamic-balance-and-speed-performance-in-collegiate-short-distance-runners-a-cross-sectional-comparative-study
#15
Selvaraj Sudhakar, S Veena Kirthika, K Padmanabhan, G Mohan Kumar, C V Senthil Nathan, R Gopika, Asir John Samuel
Objective: To compare the impact of foot arches on dynamic balance and speed performance. Materials and methods: 30 collegiate male short distance runners were divided into three groups based on foot arches, high, neutral and low. Balance and speed performance were estimated based on scores of star excursion balance test (SEBT), 40 yard dash test and vertical jump test (VJT). Results: Significant improved scores (p < 0.001) were noted in SEBT, 40 yard dash test and VJT...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656522/hybrid-t-2-and-t-1-weighted-radial-acquisition-for-free-breathing-abdominal-examination
#16
Thomas Benkert, John P Mugler, David S Rigie, Daniel K Sodickson, Hersh Chandarana, Kai Tobias Block
PURPOSE: Most clinical MR examinations require acquisition of different image contrasts. For abdominal exams, the scans are conventionally performed as separate acquisitions using respiratory gating or repeated breath holding, which can be time-inefficient and challenging for patients. Here, a hybrid imaging approach is described that creates T2 - and T1 -weighted images from a single scan and allows for free-breathing acquisition. THEORY AND METHODS: T2 -weighted data is collected using 3D fast spin-echo (FSE) acquisition with motion-robust radial stack-of-stars sampling...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29652670/multi-layer-imager-design-for-mega-voltage-spectral-imaging
#17
Marios E Myronakis, Yue-Houng Hu, Rony Fueglistaller, Adam Wang, Paul Baturin, Pascal Huber, Daniel Morf, Josh M Star-Lack, Ross I Berbeco
The architecture of multi-layer imagers (MLIs) can be exploited to provide megavoltage spectral imaging (MVSPI) for specific imaging tasks. In the current work, we investigated bone suppression and gold fiducial contrast enhancement as two clinical tasks which could be improved with spectral imaging. A method based on analytical calculations that enables rapid investigation of MLI component materials and thicknesses was developed and validated against Monte Carlo computations. The figure of merit for task-specific imaging performance was the contrast-to-noise ratio (CNR) of the gold fiducial when the CNR of bone was equal to zero after a weighted subtraction of the signals obtained from each MLI layer...
April 13, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29651332/star-formation-at-z-2-481-in-the-lensed-galaxy-sdss-j1110-6459-star-formation-down-to-30-parsec-scales
#18
Traci L Johnson, Jane R Rigby, Keren Sharon, Michael D Gladders, Michael Florian, Matthew B Bayliss, Eva Wuyts, Katherine E Whitaker, Rachael Livermore, Katherine T Murray
We present measurements of the surface density of star formation, the star-forming clump luminosity function, and the clump size distribution function, for the lensed galaxy SGAS J111020.0+645950.8 at a redshift of z =2.481. The physical size scales that we probe, radii r = 30-50 pc, are considerably smaller scales than have yet been studied at these redshifts. The star formation surface density we find within these small clumps is consistent with surface densities measured previously for other lensed galaxies at similar redshift...
July 10, 2017: Astrophysical Journal. Letters
https://www.readbyqxmd.com/read/29650484/identification-of-new-tools-to-predict-surgical-performance-of-novices-using-a-plastic-surgery-simulator
#19
Roy Kazan, Alex Viezel-Mathieu, Shantale Cyr, Thomas M Hemmerling, Samuel J Lin, Mirko S Gilardino
OBJECTIVE: To identify new tools capable of predicting surgical performance of novices on an augmentation mammoplasty simulator. The pace of technical skills acquisition varies between residents and may necessitate more time than that allotted by residency training before reaching competence. Identifying applicants with superior innate technical abilities might shorten learning curves and the time to reach competence. The objective of this study is to identify new tools that could predict surgical performance of novices on a mammoplasty simulator...
April 9, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29649967/influence-of-maternal-and-own-genotype-at-tanning-dependence-related-snps-on-sun-exposure-in-childhood
#20
Jasmine Khouja, Sarah J Lewis, Carolina Bonilla
BACKGROUND: Research suggests there may be a genetic influence on the likelihood of becoming tanning dependent (TD). The way in which mothers regulate their children's sun exposure may be affected by being TD. We investigated the associations between single nucleotide polymorphisms (SNPs) related to being TD and early sun exposure. METHODS: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used. Associations between 17 TD related SNPs in children and their mothers and 10 sun exposure variables in children (assessed via questionnaire at age 8) were analyzed in logistic and ordinal logistic regressions...
April 12, 2018: BMC Medical Genetics
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