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https://www.readbyqxmd.com/read/27900778/predicting-post-traumatic-stress-disorder-treatment-response-in-refugees-multilevel-analysis
#1
Joris F G Haagen, F Jackie June Ter Heide, Trudy M Mooren, Jeroen W Knipscheer, Rolf J Kleber
OBJECTIVES: Given the recent peak in refugee numbers and refugees' high odds of developing post-traumatic stress disorder (PTSD), finding ways to alleviate PTSD in refugees is of vital importance. However, there are major differences in PTSD treatment response between refugees, the determinants of which are largely unknown. This study aimed at improving PTSD treatment for adult refugees by identifying PTSD treatment response predictors. DESIGN: A prospective longitudinal multilevel modelling design was used to predict PTSD severity scores over time...
November 30, 2016: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/27876507/exercise-induced-cytokine-changes-in-antigen-stimulated-whole-blood-cultures-compared-to-serum
#2
C Pilat, K Krüger, T Frech, F C Mooren
Strenuous exercise is followed by an elevation of many cytokines with inflammation regulating properties. Since most cytokines act at pico- or nanomolar concentrations many investigations failed to detect their concentrations in vivo. Hence, the aim of this study was to evaluate the significance of cytokine measurements (IL-1β, TNF-α, IL-1ra, IL-6, CCL2 and CXCL8) in a stimulated whole-blood culture (sWBC) compared to serum with respect to their exercise-induced kinetics and detection rates. 40 male volunteers (age: 25,5 ± 4,3 years, BMI: 24,00 ± 2,24, VO2peak: 46,9 ± 4,1 ml/kg x min) performed 60 minutes of intensive bicycle exercise (80% VO2peak)...
November 19, 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27861303/risk-factors-clinical-features-and-treatment-outcomes-of-recurrent-mooren-ulcers-in-china
#3
Yanling Dong, Yangyang Zhang, Lixin Xie, Jianmei Ren
PURPOSE: To investigate risk factors, clinical features, and treatment outcomes of recurrent Mooren ulcers in China. METHODS: Medical records of 139 patients (173 eyes) with Mooren ulcers, including 37 patients (38 eyes) with recurrence, were retrospectively reviewed. Clinical features and treatment outcomes were evaluated. The risk factors for ulcer recurrence were analyzed with logistic regression; the cumulative risk of recurrence was assessed with Kaplan-Meier analysis...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27796668/upregulation-of-nlrp3-inflammasome-components-in-mooren-s-ulcer
#4
Zhiyuan Li, Chao Wei, Shuang Wang, Ting Liu, Hualei Zhai, Weiyun Shi
PURPOSE: Mooren's ulcer (MU) is a peripheral corneal ulceration of presumed autoimmune etiology. NLRP3 inflammasome has been shown to be involved in a variety of autoimmune and auto-inflammatory diseases. However, the role of NLRP3 inflammasome in MU has not been investigated. Here, we evaluate the expression of NLRP3 inflammasome and its downstream inflammatory factors in human MU. METHODS: Conjunctival biopsy specimens were obtained from seven patients with MU and six healthy donors...
October 28, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27760270/degradation-of-visual-performance-with-increasing-levels-of-retinal-stray-light
#5
Marrie van der Mooren, Robert Rosén, Luuk Franssen, Linda Lundström, Patricia Piers
Purpose: To quantify the effect of induced stray light on halo size, luminance threshold, and contrast sensitivity. Methods: Retinal stray light was induced in five healthy subjects using different photographic filters. The stray light induced ranged from levels observed in intraocular lenses (IOLs) with glistenings (low) to cataract level (high). The visual impact was measured for halo size, luminance detection threshold, and contrast sensitivity with and without a glare source...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27755290/mooren-ulcer-in-a-child-wearing-orthokeratology-contact-lenses
#6
Jaeyoung Kim, Mee Kum Kim, Won Ryang Wee, Joo Youn Oh
PURPOSE: To report a case of Mooren ulcer that developed in a pediatric patient wearing orthokeratology overnight contact lenses. METHODS: Case report. RESULTS: A 10-year-old boy was referred to our clinic because of progressive peripheral corneal ulcer in the right eye, despite the intensive use of fortified antibiotic eye drops. The patient had been using overnight orthokeratology lenses for 4 months before presentation of corneal ulcer...
October 13, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27745068/a-work-based-learning-approach-for-clinical-support-workers-on-mental-health-inpatient-wards
#7
Philip Kemp, Moorene Gilding, Khooseal Seewooruttun, Hannah Walsh
Background With a rise in the number of unqualified staff providing health and social care, and reports raising concerns about the quality of care provided, there is a need to address the learning needs of clinical support workers. This article describes a qualitative evaluation of a service improvement project that involved a work-based learning approach for clinical support workers on mental health inpatient wards. Aim To investigate and identify insights in relation to the content and process of learning using a work-based learning approach for clinical support workers...
September 14, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27676156/a-randomized-controlled-trial-examining-the-effects-of-16-weeks-of-moderate-to-intensive-cycling-and-honey-supplementation-on-lymphocyte-oxidative-dna-damage-and-cytokine-changes-in-male-road-cyclists
#8
Behzad Hajizadeh Maleki, Bakhtyar Tartibian, Frank C Mooren, Karsten Krüger, Leah Z FitzGerald, Mohammad Chehrazi
The aim of this study was to investigate whether honey supplementation (70g, ninety minutes before each training session) attenuates changes in lymphocyte counts, DNA damage, cytokines, antioxidative and peroxidative biomarkers following moderate-to-intensive exercise training in male road cyclists. Healthy nonprofessional cyclists (n=24, aged 17-26years) were randomly assigned to exercise+supplement (EX+S, n=12) and exercise (EX, n=12) groups for an experimental period of 16weeks. Moderate-to-intensive exercise training increased lymphocytes DNA damage, cytokines and peroxidative biomarkers as well as decreased antioxidative biomarkers in the EX group...
December 2016: Cytokine
https://www.readbyqxmd.com/read/27525377/exercise-affects-t-cell-function-via-modifying-intracellular-calcium-homeostasis
#9
Renyi Liu, Wei Fan, Karsten Krüger, Yu Xiao, Christian Pilat, Michael Seimetz, Robert Ringseis, Eveline Baumgart-Vogt, Klaus Eder, Norbert Weissmann, Frank-Christoph Mooren
PURPOSE: The study aimed to investigate the effects of chronic moderate exercise on regulation of intracellular calcium signaling as an important link to proliferation capacity in murine splenic T lymphocytes. METHODS: Male CD1 Swiss mice were randomly assigned either to a control group (CG) or an exercise group (EG). EG mice performed voluntary exercise for 3 months. Lymphocytes were isolated from murine spleens and intracellular calcium was determined using Fura-2(AM) and fluorescence spectrometry...
August 12, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27478305/effects-of-traumeel-tr14-on-exercise-induced-muscle-damage-response-in-healthy-subjects-a-double-blind-rct
#10
Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren
The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27465533/mst1-kinase-regulates-the-actin-bundling-protein-l-plastin-to-promote-t-cell-migration
#11
Xiaolu Xu, Xinxin Wang, Elizabeth M Todd, Emily R Jaeger, Jennifer L Vella, Olivia L Mooren, Yunfeng Feng, Jiancheng Hu, John A Cooper, Sharon Celeste Morley, Yina H Huang
Exploring the mechanisms controlling lymphocyte trafficking is essential for understanding the function of the immune system and the pathophysiology of immunodeficiencies. The mammalian Ste20-like kinase 1 (Mst1) has been identified as a critical signaling mediator of T cell migration, and loss of Mst1 results in immunodeficiency disease. Although Mst1 is known to support T cell migration through induction of cell polarization and lamellipodial formation, the downstream effectors of Mst1 are incompletely defined...
September 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27450147/management-of-severe-and-refractory-mooren-s-ulcers-with-rituximab
#12
Damien Guindolet, Clotilde Reynaud, Gaelle Clavel, Georges Belangé, Maycene Benmahmed, Serge Doan, Gilles Hayem, Isabelle Cochereau, Eric E Gabison
PURPOSE: Management of severe and refractory Mooren's ulcers is challenging as it encompasses tectonic surgical treatment and aggressive immunosuppressive therapies. Efficacy of rituximab in the management of severe Mooren's ulcers has never been reported. METHODS: Five patients (six eyes) from the Cornea and External Disorders department at the Rothschild Ophthalmologic Foundation (Paris, France) were treated for severe Mooren's ulcer unresponsive to conventional treatments between 2008 and 2016...
July 22, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27377816/forced-exercise-induced-osteoarthritis-is-attenuated-in-mice-lacking-the-small-leucine-rich-proteoglycan-decorin
#13
Tobias Gronau, Karsten Krüger, Carina Prein, Attila Aszodi, Isabel Gronau, Renato V Iozzo, Frank C Mooren, Hauke Clausen-Schaumann, Jessica Bertrand, Thomas Pap, Peter Bruckner, Rita Dreier
OBJECTIVE: Interterritorial regions of articular cartilage matrix are rich in decorin, a small leucine-rich proteoglycan and important structural protein, also involved in many signalling events. Decorin sequesters transforming growth factor β (TGFβ), thereby regulating its activity. Here, we analysed whether increased bioavailability of TGFβ in decorin-deficient (Dcn(-/-)) cartilage leads to changes in biomechanical properties and resistance to osteoarthritis (OA). METHODS: Unchallenged knee cartilage was analysed by atomic force microscopy (AFM) and immunohistochemistry...
July 4, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27369484/authors-reply
#14
F Jackie June Ter Heide, Trudy M Mooren, Ad de Jongh, Rolf J Kleber
No abstract text is available yet for this article.
July 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/27361486/apoptosis-of-t-cells-subpopulations-is-differently-affected-by-high-intensity-interval-exercise-compared-to-isocaloric-continuous-exercise-2917-june-3-2-15-pm-2-30-pm
#15
Karsten Krüger, Katharina Alack, Lena Mink, Elisabeth Pfeifer, Katharina Gindler, Torsten Frech, Frank C Mooren
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27361484/apoptosis-affects-mobilization-of-hematopoietic-progenitors-into-blood-after-exercise-2915-june-3-1-45-pm-2-00-pm
#16
Frank C Mooren, Karsten Krüger
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360382/effects-of-a-natural-combination-medicine-on-exercise-induced-muscle-soreness-1463-board-116-june-2-8-00-am-9-30-am
#17
Christian Pilat, Kerstin Muders, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Christine Scheibelhut, Frank-Christoph Mooren
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27347060/keratopathy-due-to-ophthalmic-drug-abuse-with-corneal-melting-and-perforation-presenting-as-mooren-like-ulcer-a-case-report
#18
Hui Wu, Yuan Hu, Xiao-Ru Shi, Feihong Xu, Chun-Ying Jiang, Rong Huang, Hui Jia
The present report describes the clinical course and treatment of a Mooren-like ulcer associated with abuse of topical anesthetics and dexamethasone. A 38-year-old male physician treated himself with lidocaine, tetracaine and dexamethasone (DEX) eye drops for severe pain and decline of vision in both eyes. After six months of treatment, his right cornea exhibited annular melting with full-thickness stromal infiltration at the limbus and central corneal haze. His left cornea was completely melted and exhibited iris prolapse...
July 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27339001/evolution-of-2009-h1n1-influenza-viruses-during-the-pandemic-correlates-with-increased-viral-pathogenicity-and-transmissibility-in-the-ferret-model
#19
Anna Otte, Anthony C Marriott, Carola Dreier, Brian Dove, Kyra Mooren, Thorsten R Klingen, Martina Sauter, Katy-Anne Thompson, Allan Bennett, Karin Klingel, Debby van Riel, Alice C McHardy, Miles W Carroll, Gülsah Gabriel
There is increasing evidence that 2009 pandemic H1N1 influenza viruses have evolved after pandemic onset giving rise to severe epidemics in subsequent waves. However, it still remains unclear which viral determinants might have contributed to disease severity after pandemic initiation. Here, we show that distinct mutations in the 2009 pandemic H1N1 virus genome have occurred with increased frequency after pandemic declaration. Among those, a mutation in the viral hemagglutinin was identified that increases 2009 pandemic H1N1 virus binding to human-like α2,6-linked sialic acids...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27315263/monitoring-and-evaluating-psychosocial-intervention-outcomes-in-humanitarian-aid
#20
Kaz de Jong, Cono Ariti, Saskia van der Kam, Trudy Mooren, Leslie Shanks, Giovanni Pintaldi, Rolf Kleber
Existing tools for evaluating psychosocial interventions (un-validated self-reporting questionnaires) are not ideal for use in non-Western conflict settings. We implement a generic method of treatment evaluation, using client and counsellor feedback, in 18 projects in non-Western humanitarian settings. We discuss our findings from the perspective of validity and suggestions for future research. A retrospective analysis is executed using data gathered from psychosocial projects. Clients (n = 7,058) complete two (complaints and functioning) rating scales each session and counsellors rate the client's status at exit...
2016: PloS One
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