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https://www.readbyqxmd.com/read/29650812/-clinical-implementation-of-precision-medicine
#1
Shuta Tomida, Shinichi Toyooka
In the end of last year, the US Food and Drug Administration has announced the authorization of MSK-IMPACT(TM), clinical test based on multiplex cancer panel profiling for genetic mutations and other alterations in patients' tumors, while in Japan, NCC Oncopanel, domestic multiplex cancer panel, is scheduled to be clinically implemented as advanced medical care B in this coming spring, chasing the state of the art technology for cancer treatment. In this article, we outline a recently published roadmap for precision medicine in Japan, together with our years of experience on cancer diagnosis and treatment based on multiplex cancer panel at Okayama University Hospital and Okadai Biobank...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29572263/gender-differences-in-the-associations-of-body-mass-index-physical-fitness-and-tobacco-use-with-lower-extremity-musculoskeletal-injuries-among-new-us-army-soldiers
#2
Sheryl A Bedno, D Alan Nelson, Lianne M Kurina, Y Sammy Choi
BACKGROUND: Musculoskeletal (MSK) injuries are a leading cause of morbidity among US Army soldiers, especially among women and the newly enlisted. While extremes of body mass index (BMI), low physical fitness and tobacco use have been identified as risk factors, no prior studies have determined the combined effects of these risk factors or tested for gender differences in the associations. METHODS: We conducted a retrospective cohort study utilising the Stanford Military Data Repository to study all enlisted soldier accessions to the US Army between January 2011 and January 2014, with follow-up through December 2014 (n=238 772)...
March 23, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29339205/agreement-of-musculoskeletal-ultrasound-and-clinical-assessment-of-shoulder-impairment-in-manual-wheelchair-users-with-various-duration-of-spinal-cord-injury
#3
Margaret Finley, David Ebaugh, Thomas Trojian
OBJECTIVES: To determine (1) agreement of musculoskeletal ultrasound (MSK-US) findings of shoulder pathology and related shoulder special test results in individuals with varied durations of manual wheelchair (MWC) use after spinal cord injury (SCI); and (2) whether shoulder musculoskeletal impairments, per MSK-US and clinical examination, differed in individuals with SCI and varying durations of MWC use. DESIGN: Cross-sectional cohort study. SETTING: Laboratory setting...
April 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29246525/comparative-trends-in-utilization-of-mri-and-ultrasound-to-evaluate-nonspine-joint-disease-2003-to-2015
#4
Riti M Kanesa-Thasan, Levon N Nazarian, Laurence Parker, Vijay M Rao, David C Levin
PURPOSE: MRI and ultrasound (US) are effective diagnostic tools to evaluate extremities. In this study, we analyze utilization trends in musculoskeletal (MSK) US and MRI from 2003 to 2015 within the Medicare population. METHODS: Our data sources were the Medicare Part B Physician/Supplier Procedure Summary Master Files for 2003 to 2015. They cover all Medicare fee-for-service enrollees (37.5 million in 2015). Current Procedural Terminology codes for nonvascular, nonspine joint MRI and extremity US were selected and volumes within these codes were determined...
March 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29075524/diagnostic-errors-in-musculoskeletal-ultrasound-imaging-and-how-to-avoid-them
#5
REVIEW
Małgorzata Serafin-Król, Artur Maliborski
The article reviews the major challenges related to the principles of the correct technique of musculoskeletal ultrasound (MSK US). All the crucial aspects of correct MSK soft tissue diagnosis have been discussed, including equipment settings, use of recent image software innovations and ultrasound standoff pads, and correct transducer positioning. The importance of the fundamental principles of MSK US, facilitating good quality image and limiting the occurrence of artifacts, has been highlighted. The most common artifacts of the musculoskeletal system have been described, including those that diagnostically helpful, such as the presence of echo enhancement deep to a fluid-filled structure, or an acoustic shadow behind a calcification...
September 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28755330/a-critical-appraisal-of-the-quality-of-adult-musculoskeletal-ultrasound-guidelines-using-the-agree-ii-tool-an-euroaim-initiative
#6
Carmelo Messina, Bianca Bignotti, Alberto Tagliafico, Davide Orlandi, Angelo Corazza, Francesco Sardanelli, Luca Maria Sconfienza
OBJECTIVES: Our aim was to evaluate the quality of published guidelines on musculoskeletal ultrasound (MSK-US) for adults. METHODS: Between June and July 2016, we conducted an online search for MSK-US guidelines, which were evaluated by four independent readers blinded to each other using the AGREE II tool. A fifth independent reviewer calculated scores per each domain and agreement between reviewers' scores using the intraclass correlation coefficient (ICC). RESULTS: Five guidelines were included in this appraisal...
October 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28720423/undergraduate-clinical-teaching-in-orthopedic-surgery-a-randomized-control-trial-comparing-the-effect-of-case-based-teaching-and-bedside-teaching-on-musculoskeletal-osce-performance
#7
Martin Kelly, Iain Feeley, Fiona Boland, John M O'Byrne
INTRODUCTION: Musculoskeletal (MSK) complaints are the second most common reason for a hospital outpatient appointment in the US, and account for 19.5% of general practice consultations. Previous studies have shown that passive teaching in medical school does not imbue students with an adequate degree of confidence in MSK evaluation. The aim of this study was to conduct a randomized control trial to compare the effect of the gold standard small group tutorial of bedside teaching against case-based teaching (CBT) in relation to orthopedic surgery in medical students...
January 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/28623421/comparison-of-dual-energy-ct-ultrasound-and-surface-measurement-for-assessing-tophus-dissolution-during-rapid-urate-debulking
#8
Dodji V Modjinou, Svetlana Krasnokutsky, Soterios Gyftopoulos, Virginia C Pike, Elaine Karis, Robert T Keenan, Kristen Lee, Daria B Crittenden, Jonathan Samuels, Michael H Pillinger
Tophaceous gout is painful and impairs quality of life. The optimal modality for assessing tophus resolution in response to urate-lowering treatment remains poorly defined. Using pegloticase as a model system for resolving tophi, we compared multiple imaging and physical diagnostic strategies for assessing tophus resolution. A 32-year-old subject with chronic refractory tophaceous gout was enrolled and received 6 months of pegloticase treatment. Measurements of tophi using vernier calipers (monthly), photographs and musculoskeletal ultrasound (MSK-US; every 3 months), and dual-energy CT (DECT) were compared...
September 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28389399/integrating-musculoskeletal-education-and-patient-care-at-medical-student-run-free-clinics
#9
Thomas McQuillan, Nate Wilcox-Fogel, Emily Kraus, Amy Ladd, Michael Fredericson
BACKGROUND: Student-run free clinics (SRFCs) have emerged as an important educational component of United States (U.S.) medical schools. Despite the prevalence of musculoskeletal (MSK) problems presenting to SRFCs, students and clinics are often unprepared to diagnose and to treat common MSK complaints. OBJECTIVE: We sought to determine the scope of diagnosis and treatment at a medical student-run free clinic specializing in musculoskeletal care using physical medicine and rehabilitation (PM&R) residents...
November 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27973548/the-chromatin-modifier-msk1-2-suppresses-endocrine-cell-fates-during-mouse-pancreatic-development
#10
Neha Bhat, Jeehye Park, Huda Y Zoghbi, J Simon C Arthur, Kenneth S Zaret
Type I diabetes is caused by loss of insulin-secreting beta cells. To identify novel, pharmacologically-targetable histone-modifying proteins that enhance beta cell production from pancreatic progenitors, we performed a screen for histone modifications induced by signal transduction pathways at key pancreatic genes. The screen led us to investigate the temporal dynamics of ser-28 phosphorylated histone H3 (H3S28ph) and its upstream kinases, MSK1 and MSK2 (MSK1/2). H3S28ph and MSK1/2 were enriched at the key endocrine and acinar promoters in E12...
2016: PloS One
https://www.readbyqxmd.com/read/27831746/the-interrelationship-of-common-clinical-movement-screens-establishing-population-specific-norms-in-a-large-cohort-of-military-applicants
#11
Sarah J de la Motte, Timothy C Gribbin, Peter Lisman, Anthony I Beutler, Patricia Deuster
CONTEXT:  Musculoskeletal injuries (MSK-Is) are a leading cause of missed duty time and morbidity in the military. Modifiable risk factors for MSK-Is, such as inadequate core stability, poor movement patterns, and dynamic balance deficits, have not been identified in military applicants on entering service. OBJECTIVE:  To establish normative functional movement data using a series of screens in military applicants entering basic training and explore relationships among several movement tests...
November 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27672904/poster-137-delayed-diagnosis-of-popliteal-artery-entrapment-mistaken-for-exertional-compartment-syndrome-novel-use-of-msk-us-to-improve-diagnostic-sensitivity-a-case-report
#12
Ilya Igolnikov, Matthew J Santiago, Kathryn T Gollotto
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27413444/effectiveness-of-an-interprofessional-and-multidisciplinary-musculoskeletal-training-program
#13
Michael J Battistone, Andrea M Barker, Marissa P Grotzke, J Peter Beck, Jeffery T Berdan, Jorie M Butler, Caroline K Milne, Tim Huhtala, Grant W Cannon
BACKGROUND: Musculoskeletal (MSK) problems are common, and a recent US Bone and Joint Initiative calls for new models of education and professional collaboration. Evidence of feasibility and acceptability of innovative methods are needed. OBJECTIVE: We assessed if an experimental immersion interdisciplinary MSK curriculum would be acceptable to residents from different specialties, be feasible within existing rotations, and be effective in strengthening clinical skills...
July 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/27081781/suppression-of-sik1-by-mir-141-in-human-ovarian-cancer-cell-lines-and-tissues
#14
Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Epithelial ovarian cancer (EOC), the sixth most common cancer in women worldwide, is the most commonly fatal gynecologic malignancy in developed countries. One of the main reasons for this is that relatively little was known about the molecular events responsible for the development of this highly aggressive disease. In the present study, we demonstrated that salt‑inducible kinase 1 (SIK1; which is also known as MSK/SIK/SNF1LK) was downregulated in ovarian cancer tissue samples. Using HEY ovarian cancer cells, we noted that SIK1 overexpression inhibited proliferation as well as cancer stem cell-associated traits...
June 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/26830280/ultrasound-examination-of-pediatric-musculoskeletal-diseases-and-neonatal-spine
#15
REVIEW
Alka Sudhir Karnik, Alpana Karnik, Alpana Joshi
Ultrasound (US) is a simple, non-invasive imaging modality which allows high-resolution imaging of the musculoskeletal (MSK) system. Its increasing popularity in pediatrics is due to the fact that it does not involve radiation, has an ability to visualize non-ossified cartilaginous and vascular structures, allows dynamic imaging and quick contralateral comparison. US is the primary imaging modality in some pediatric MSK conditions like infant hip in developmental dysplasia (DDH), hip joint effusion, epiphyseal trauma and evaluation of the neonatal spine...
June 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/26690019/resident-accuracy-of-electromyography-needle-electrode-placement-using-ultrasound-verification
#16
Kristopher Karvelas, Craig Ziegler, Monica E Rho
BACKGROUND: Electromyography (EMG) and musculoskeletal (MSK) ultrasound (US) are core learning objectives during physical medicine and rehabilitation (PM&R) training. However, there have been no prior studies using MSK US to assess the acquisition of EMG procedural skills during residency training. This study aims to demonstrate the differences in skillful needle placement between junior and senior physiatry residents. The integration of both EMG and MSK US may have tremendous potential for additional learning opportunities related to electrodiagnostic education...
August 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/26641833/feasibility-and-implementation-of-musculoskeletal-ultrasound-training-in-occupational-medicine-residency-education
#17
Yusef Sayeed, Antonella Marrocco, Keziah Sully, Charles Werntz, Anna Allen, Joseph Minardi
OBJECTIVE: This article aims to present the musculoskeletal (MSK) ultrasound (US) course, the objective measures of occupational medicine (OM) resident skill, and subjective opinions of OM residents regarding the MSK US course and MSK US in general. Also, to provide other OM residency programs information to help them develop this skill for their programs. METHODS: Didactic sessions based on American Institute of Ultrasound in Medicine (AIUM) guidelines were taught in modular format with subsequent practice-based workshops...
December 2015: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/26614546/proceedings-from-the-8th-annual-international-society-for-musculoskeletal-imaging-in-rheumatology-isemir-conference
#18
Orrin M Troum, Olga L Pimienta, Ewa Olech, Mikkel Østergaard, Ralf Thiele, Judy L Seraphine, George A W Bruyn, Charles Peterfy
The International Society for Musculoskeletal Imaging in Rheumatology (ISEMIR) was founded in 2005 with the goal of discussing matters related to imaging in rheumatology, particularly, validation, education, and use in both clinical practice and research. The field of musculoskeletal (MSK) imaging is continuously evolving; therefore, education for healthcare providers in this field is of paramount importance. ISEMIR's international faculty and world-renowned experts presented the newest information as it relates to the use of magnetic resonance imaging (MRI) and ultrasound (US) at the 8th annual ISEMIR meeting that took place on April 17-18 in Santa Monica, California...
June 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/26282389/musculoskeletal-medicine-is-underrepresented-in-the-american-medical-school-clinical-curriculum
#19
Benedict F DiGiovanni, Leigh T Sundem, Richard D Southgate, David R Lambert
BACKGROUND: Musculoskeletal (MSK) conditions are common, and their burden on the healthcare system is increasing as the general population ages. It is essential that medical students be well prepared to evaluate and treat MSK disorders in a confident manner as they enter the workforce. Recent studies and the American Association of Medical Colleges have raised concern that medical schools may not give sufficient instruction on this topic. Other authors have shown that preclinical instruction has increased over the past decade; however, it is unclear if required clinical instruction also has followed that trend...
April 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/26258970/-the-imaging-of-musculoskeletal-manifestations-and-complications-in-diabetes-mellitus
#20
Jindra Brtková
The musculoskeletal system is one of the major regions, where changes caused by diabetes mellitus (DM) are often encountered causing severe impairment of the quality of patients´ lives. These changes have therefore become an important focus of diagnostic and therapeutic procedures, with imaging methods - both plain radiography, computed tomography (CT), magnetic resonance imaging (MRI) and to a lesser extent ultrasound (US), being their cornerstones. In the article the images of musculoskeletal (MSK) manifestations of diabetes mellitus are presented, structured into changes directly caused by DM, metabolic consequences of DM, syndromes with increased coincidence with DM and septic complications...
June 2015: Vnitr̆ní Lékar̆ství
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