keyword
https://read.qxmd.com/read/38536707/yoga-based-interventions-in-low-income-populations-a-scoping-review
#1
JOURNAL ARTICLE
Megha V Nagaswami, Robert B Saper, Chris C Streeter, Lisa Uebelacker, Grace Ding, Anika Dalvie, Richard Norton, David Mischoulon, Maren B Nyer
Introduction: The popularity of yoga has surged in recent years; however, yoga practitioners have remained a largely homogenous population. Research reflects that most practitioners are of a higher socioeconomic status. There are access barriers to yoga for lower income individuals, likely due to factors such as financial constraints and logistical challenges. The primary goal of this review was to synthesize literature on yoga research among low-income populations and better understand the feasibility and acceptability of such interventions...
March 27, 2024: J Integr Complement Med
https://read.qxmd.com/read/38536518/prognostic-modeling-in-early-rheumatoid-arthritis-reconsidering-the-predictive-role-of-disease-activity-scores
#2
JOURNAL ARTICLE
Alix Bird, Lauren Oakden-Rayner, Luke A Smith, Minyan Zeng, Shonket Ray, Susanna Proudman, Lyle J Palmer
OBJECTIVE: In this prospective cohort study, we provide several prognostic models to predict functional status as measured by the modified Health Assessment Questionnaire (mHAQ). The early adoption of the treat-to-target strategy in this cohort offered a unique opportunity to identify predictive factors using longitudinal data across 20 years. METHODS: A cohort of 397 patients with early RA was used to develop statistical models to predict mHAQ score measured at baseline, 12 months, and 18 months post diagnosis, as well as serially measured mHAQ...
March 27, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38532530/effects-of-eccentric-versus-concentric-strengthening-in-patients-with-subacromial-pain-syndrome-a-randomized-controlled-trial
#3
JOURNAL ARTICLE
Damla Karabay, Sevgi Sevi Yeşilyaprak, Mehmet Erduran, Cem Ozcan
BACKGROUND: Subacromial pain syndrome (SPS) is the most common cause of shoulder pain. Therapeutic exercise is the first-line treatment for SPS; however, the ideal exercise type remains unclear. Here, we compared the effects of eccentric and concentric strengthening in patients with SPS. HYPOTHESIS: Adding isolated eccentric strengthening to a multimodal physiotherapy program (MPP) would lead to greater improvements in outcomes compared with either MPP alone or adding isolated concentric strengthening to the MPP...
March 26, 2024: Sports Health
https://read.qxmd.com/read/38529017/tizanidine-advances-in-pharmacology-therapeutics-and-drug-formulations
#4
REVIEW
Ling-Ling Zhu, Yan-Hong Wang, Quan Zhou
BACKGROUND: Skeletal muscle relaxants (SMRs) are widely used in treating musculoskeletal conditions. All SMRs, with the exception of baclofen and tizanidine, are on the list of 2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults. In our geriatric practice, off-label use of tizanidine as preemptive analgesia drove us to find recent advances in its pharmacology and therapeutics. An update review of tizanidine was thus presented, aiming to bring the latest knowledge to clinicians and promote further research and practical exploration...
2024: Journal of Pain Research
https://read.qxmd.com/read/38524942/crisp-an-inpatient-pediatric-curriculum-for-family-medicine-residents-using-clinical-reasoning-and-illness-scripts
#5
JOURNAL ARTICLE
Gayatri B Madduri, Elizabeth L Torwekar, Shaban Demirel, Megan Durham, Kimberlee I Hauff, Rajat Kaul, Tristan Nichols, Noga L Ravid, Mason A Shaner, Caroline E Rassbach
INTRODUCTION: Clinical reasoning enables safe patient care and is an important competency in medical education but can be challenging to teach. Illness scripts facilitate clinical reasoning but have not been used to create pediatric curricula. METHODS: We created CRISP (Clinical Reasoning with Illness Scripts in Pediatrics), a curriculum comprising four 1-hour learning sessions that deliberately incorporated clinical reasoning concepts and illness scripts to organize how four common chief complaints were taught to family medicine residents on inpatient pediatric rotations...
2024: MedEdPORTAL Publications
https://read.qxmd.com/read/38524538/impact-of-the-addition-of-dexmedetomidine-to-patient-controlled-intravenous-analgesia-on-postoperative-pain-sleep-interaction-cycle-and-delirium-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
JOURNAL ARTICLE
Wenjie Xu, Yuxiang Zheng, Qing Wang, Zizheng Suo, Lingling Fang, Jing Yang, Shuai Li, Peng Li, Xixi Jia, Xiaoyan Liu, Hui Zheng, Cheng Ni
BACKGROUND: The reciprocal nexus between sleep and pain is well-documented, with the deleterious impact of operative trauma potentially playing a pivotal role in the dysregulation of this interplay, which could significantly contribute to the manifestation of postoperative delirium (POD). Studies have investigated the effect of adding dexmedetomidine (DEX) to patient-controlled intravenous analgesia (PCIA) pumps on postoperative pain-sleep interaction cycle and POD, but conclusions remained uncertain...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524518/efficacy-of-borneol-gypsum-in-skin-regeneration-and-pain-control-in-toxic-epidermal-necrolysis-a-case-report
#7
Lu-Wei Yang, Li-Juan Zhang, Bin-Bin Zhou, Xin-Yu Lin, Yu-Ting Chen, Xiao-Yu Qin, Hui-Ying Tian, Li-Li Ma, Ying Sun, Lin-Di Jiang
BACKGROUND: Toxic epidermal necrolysis (TEN) is a life-threatening dermatological emergency mainly induced by drug hypersensitivity reactions. Standard management includes discontinuation of culprit drug and application of immunomodulatory therapy. However, mortality remains high due to complications like septic shock and multiorgan failures. Innovative approaches for skin care are crucial. This report introduces borneol-gypsum, a traditional Chinese drug but a novel dressing serving as an adjuvant of TEN therapy, might significantly improve skin conditions and patient outcomes in TEN...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38524386/orthopaedic-hand-patient-support-systems-have-valuable-insight-to-patient-function-and-pain
#8
JOURNAL ARTICLE
E A Washnock-Schmid, Nicholas Livingston, Katie Latack, Nancy Wrobel, Charles S Day
Patient-reported outcome measures (PROs) are increasingly used in clinical assessment. Research on how patient support systems contribute to physician understanding of patient condition is limited. Thus, insights from significant others may provide value, especially when concerns exist regarding patient response validity. Patients recruited from the pre-operative environment undergoing orthopaedic hand procedures responded to PROMIS-Pain Interference (PI), PROMIS-Upper Extremity (UE), PROMIS-Depression (D), and QuickDASH...
2024: Journal of Patient Experience
https://read.qxmd.com/read/38524243/profile-of-caregiving-activities-and-association-with-physical-health-among-dementia-spousal-caregivers
#9
JOURNAL ARTICLE
Jinmyoung Cho, Laura P Sands, Alan B Stevens, Heather G Allore, Molly J Horstman
BACKGROUND AND OBJECTIVES: This study aims to identify patterns of caregiving intensity and assess associations between caregiving intensity and multidimensional physical health indicators and health behaviors among spousal caregivers of persons with Alzheimer's disease and related dementia. RESEARCH DESIGN AND METHODS: Using data from 152 spousal caregivers aged 65 and older, the intensity of their caregiving experience was measured as the number and frequency of health- and medical-related helping activities for their care recipient...
2024: Innovation in Aging
https://read.qxmd.com/read/38524044/naturopathic-interventions-for-reduction-of-perceived-pain-in-patients-suffering-from-arthritis-a-systematic-review-and-meta-analysis
#10
REVIEW
Himel Mondal, Satyalakshmi Komarraju, Sathyanath D, Shrikanth Muralidharan
Arthritis affects millions of lives with its pervasive effects on physical health and quality of life. Addressing the complexities of managing symptoms such as swelling, inflammation, and pain requires prolonged treatment. Naturopathy is a treatment method that enhances the body's innate ability to restore optimal health through a holistic approach including natural products and lifestyle modifications. This systematic review addresses the intersection of naturopathy and arthritis treatment to provide current evidence about its potential benefits...
February 2024: Curēus
https://read.qxmd.com/read/38521904/clinical-and-radiologic-outcomes-in-patients-with-meniscal-root-tears
#11
JOURNAL ARTICLE
Rawee Manatrakul, Maximilian Loeffler, Upasana U Bharadwaj, Gabby B Joseph, Drew Lansdown, Brian Feeley, Joe D Baal, Julio B Guimaraes, Thomas M Link
BACKGROUND: Meniscal root tears can lead to early knee osteoarthritis and pain. This study aimed (1) to compare clinical and radiological outcomes between patients who underwent arthroscopic meniscal root repair after meniscal root tears and those who received non-surgical treatment, and (2) to identify whether baseline MRI findings could be potential predictors for future treatment strategies. METHODS: Patients with meniscal root tears were identified from our picture archiving and communication system from 2016 to 2020...
March 23, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38518466/a-case-report-on-appendicular-diverticulitis-eluding-traditional-diagnosis
#12
Midhun Mathew, Mohammed Fajar Al Sadiq, Vinod Gopalkrishna Pillai
INTRODUCTION AND IMPORTANCE: Diverticula of the vermiform appendix are rare entities. Although the pathogenesis and natural course of appendiceal diverticulitis (AD) are different from acute appendicitis, AD is treated like acute appendicitis because of similar clinical manifestations and low incidence. CASE PRESENTATION: We describe cases of two male patients of different ages who respectively underwent elective laparoscopic appendectomy and an emergent laparoscopic appendectomy in a multi-speciality hospital in Kerala, India...
March 19, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38517770/efficacy-of-ultrasound-guided-galvanic-electrolysis-technique-and-physical-therapy-in-patients-with-achilles-tendinopathy-a-pilot-randomised-controlled-trial
#13
JOURNAL ARTICLE
Marco Di Gesù, Angelo Alito, Daniele Borzelli, Domenico Romeo, Fabio Bonomolo, Dario Calafiore, Alessandro de Sire
BACKGROUND: Ultrasound-guided galvanic electrolysis technique (USGET) is an innovative mini-invasive intervention with the potential to optimise outcomes in the treatment of Achille's tendinopathy (AT). OBJECTIVE: The aim of this pilot study is to evaluate the efficacy of adding USGET to conventional eccentric exercise treatment in patients with chronic AT. METHODS: Inclusion criteria were patients with unilateral non-insertional AT, pain lasting > 3 months, aged 25-60 years...
February 28, 2024: Journal of Back and Musculoskeletal Rehabilitation
https://read.qxmd.com/read/38517648/identification-of-novel-potential-cathepsin-b-inhibitors-through-pharmacophore-based-virtual-screening-molecular-docking-and-dynamics-simulation-studies-for-the-treatment-of-alzheimer-s-disease
#14
JOURNAL ARTICLE
Jatin Jangra, Nilesh Gajanan Bajad, Ravi Singh, Ashok Kumar, Sushil Kumar Singh
Cathepsin B is a cysteine protease lysosomal enzyme involved in several physiological functions. Overexpression of the enzyme enhances its proteolytic activity and causes the breakdown of amyloid precursor protein (APP) into neurotoxic amyloid β (Aβ), a characteristic hallmark of Alzheimer's disease (AD). Therefore, inhibition of the enzyme is a crucial therapeutic aspect for treating the disease. Combined structure and ligand-based drug design strategies were employed in the current study to identify the novel potential cathepsin B inhibitors...
March 22, 2024: Molecular Diversity
https://read.qxmd.com/read/38514395/comparative-effectiveness-study-evaluating-outcomes-for-transforaminal-epidural-steroid-injections-performed-with-3-hypertonic-saline-or-normal-saline-in-lumbosacral-radicular-pain
#15
JOURNAL ARTICLE
Sithapan Munjupong, Wanwipha Malaithong, Ekasak Chantrapannik, Poomin Ratchano, Nuj Tontisirin, Steven P Cohen
BACKGROUND: Transforaminal epidural steroid injection (TFESI) are commonly employed to treat lumbosacral radiculopathy. Despite anti-inflammatory properties, the addition of 3% hypertonic saline has not been studied. OBJECTIVE: Compare the effectiveness of adding 0.9% NaCl (N-group) vs. 3% NaCl (H-group) in TFESI performed for lumbosacral radiculopathy. METHODS: This retrospective study compared TFESI performed with lidocaine, triamcinolone and 0...
March 21, 2024: Pain Medicine
https://read.qxmd.com/read/38513683/mri-guided-stereotactic-ablative-body-radiotherapy-versus-ct-guided-percutaneous-irreversible-electroporation-for-locally-advanced-pancreatic-cancer-crossfire-a-single-centre-open-label-randomised-phase-2-trial
#16
JOURNAL ARTICLE
Florentine E F Timmer, Bart Geboers, Alette H Ruarus, Laurien G P H Vroomen, Evelien A C Schouten, Susan van der Lei, Danielle J W Vos, Madelon Dijkstra, Hannah H Schulz, Joyce Bakker, Bente A T van den Bemd, Petrousjka M van den Tol, Robbert S Puijk, Birgit I Lissenberg-Witte, Tanja D de Gruijl, Jan J J de Vries, Frank J Lagerwaard, Hester J Scheffer, Anna M E Bruynzeel, Martijn R Meijerink
BACKGROUND: Pancreatic ductal adenocarcinoma is an aggressive disease with a dismal prognosis. Stage III locally advanced pancreatic cancer is considered unresectable and current palliative chemotherapy regimens only modestly improve survival. Guidelines suggest chemoradiation or stereotactic ablative body radiotherapy (SABR) could be beneficial in certain circumstances. Other local treatments such as irreversible electroporation could enhance patient outcomes by extending survival while preserving quality of life...
March 18, 2024: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/38511070/the-effects-of-exercise-and-intra-articular-injections-versus-exercise-alone-for-the-treatment-of-knee-osteoarthritis-a-scoping-review-of-the-evidence
#17
REVIEW
Sydney C Liles, Bradley Bley, Daniel K White
OBJECTIVE: Current treatment for knee Osteoarthritis (OA) includes exercise and intra-articular injections with corticosteroid (CS), hyaluronic acid (HA), etc., which address OA-related pain and functional limitation. While these interventions can be given together, little is known about the efficacy of a multi-modal approach. The purpose of this scoping review is to examine studies that compare combining exercise and intra-articular knee injections to exercise alone for the management of knee OA...
June 2024: Osteoarthritis and cartilage open
https://read.qxmd.com/read/38510875/effectiveness-of-arthroscopic-debridement-trapeziectomy-and-joint-replacement-for-trapeziometacarpal-joint-osteoarthritis-a-meta-analysis-of-pre-and-postoperative-pain-scores
#18
REVIEW
Kassem Ghayyad, Nikita Golovachev, Nathan Sarli, David Hirsch, Babak Shojaie, Amir R Kachooei
Trapeziometacarpal joint osteoarthritis (TMJO) affects up to 33% of postmenopausal women, leading to pain, reduced mobility, and grip strength, with initial treatments focusing on non-surgical options like injections, orthoses, and exercises before considering surgery. A major challenge in managing TMJO involves selecting the optimal surgical strategy that is customized to individual clinical conditions. This study aimed to compare the effectiveness of three common surgical interventions for TMJO in relieving pain, including arthroscopic debridement (AD), trapeziectomy (TRAP), and joint replacement (JR)...
February 2024: Curēus
https://read.qxmd.com/read/38509320/revolutionizing-brain-interventions-the-multifaceted-potential-of-histotripsy
#19
REVIEW
Yash Verma, Arosh S Perera Molligoda Arachchige
Histotripsy, a non-thermal ultrasound technique, holds significant promise in various applications within the realm of brain interventions. While its use for treating brain tumors is somewhat limited, focused ultrasound technology has been extensively investigated for a wide range of purposes within the brain, including disrupting the blood-brain barrier, supporting immunotherapy, addressing conditions like essential tremor, Parkinson's disease, Alzheimer's disease, epilepsy, and neuropathic pain. Research findings indicate that histotripsy can reduce tumor cells with fewer pulses, minimizing the risk of bleeding and cellular injury...
March 21, 2024: Neurosurgical Review
https://read.qxmd.com/read/38507844/in-silico-exploration-of-cb2-receptor-agonist-in-the-management-of-neuroinflammatory-conditions-by-pharmacophore-modeling
#20
JOURNAL ARTICLE
Shlok Bodke, Nachiket Joshi, Rajasekhar Reddy Alavala, Divya Suares
Endocannabinoid system plays a pivotal role in controlling neuroinflammation, and modulating this system may not only aid in managing symptoms of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy, Central and Peripheral neuropathic pain, but also, have the potential to target these diseases at an early-stage. In the present study, six different pharmacophore hypotheses were generated from Cannabidiol (CBD)-Cannabinoid Receptor subtype-2 (CB2) and then Zinc database was screened for identification of hit molecules...
March 10, 2024: Computational Biology and Chemistry
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