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https://www.readbyqxmd.com/read/29126782/feasibility-and-limitations-of-mitral-valve-repair-with-or-without-left-ventricular-reconstruction-in-non-ischemic-dilated-cardiomyopathy
#1
Yasushige Shingu, Tomonori Ooka, Hiroki Katoh, Tsuyoshi Tachibana, Suguru Kubota, Yoshiro Matsui
BACKGROUND: Although non-transplant surgical interventions for non-ischemic dilated cardiomyopathy (NIDCM) are relatively effective, their feasibility and limitations have not been fully elucidated. The aim of this study was to define the feasibility and limitations of mitral valve repair, with or without surgical ventricular reconstruction for patients with NIDCM in terms of postoperative low cardiac output syndrome (LOS). METHODS: Twenty non-transplant candidates (aged 57±13 years) with NIDCM and significant mitral regurgitation had undergone mitral valve repair combined with submitral procedures...
November 7, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29074465/comparison-of-three-dimensional-helical-axes-of-the-cervical-spine-between-in-vitro-and-in-vivo-testing
#2
René Jonas, Robert Demmelmaier, Steffen P Hacker, Hans-Joachim Wilke
BACKGROUND CONTEXT: The range of motion is a well-accepted parameter for the assessment and evaluation of cervical motion. However, more qualitative data of the kinematics of the cervical spine is needed for the development and success of cervical disc arthroplasty [1]. PURPOSE: The aim of this study was to provide basic information about helical axes of human cervical spine under in vitro conditions. Furthermore it should clarify whether the three-dimensional helical axes of cervical motion gained from in vitro experiments are in agreement with those gained from in vivo experiments and therefore to prove its reliability...
October 23, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29061576/sodium-glucose-cotransporter-2-inhibition-in-heart-failure-potential-mechanisms-clinical-applications-and-summary-of-clinical-trials
#3
REVIEW
Yuliya Lytvyn, Petter Bjornstad, Jacob A Udell, Julie A Lovshin, David Z I Cherney
Despite current established therapy, heart failure (HF) remains a leading cause of hospitalization and mortality worldwide. Novel therapeutic targets are therefore needed to improve the prognosis of patients with HF. The EMPA-REG OUTCOME trial ([Empagliflozin] Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) demonstrated significant reductions in mortality and HF hospitalization risk in patients with type 2 diabetes mellitus (T2D) and cardiovascular disease with the antihyperglycemic agent, empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor...
October 24, 2017: Circulation
https://www.readbyqxmd.com/read/29056408/effect-of-gravitational-gradients-on-cardiac-filling-and-performance
#4
Kazuaki Negishi, Allen G Borowski, Zoran B Popović, Neil L Greenberg, David S Martin, Michael W Bungo, Benjamin D Levine, James D Thomas
BACKGROUND: Gravity affects every aspect of cardiac performance. When gravitational gradients are at their greatest on Earth (i.e., during upright posture), orthostatic intolerance may ensue and is a common clinical problem that appears to be exacerbated by the adaptation to spaceflight. We sought to elucidate the alterations in cardiac performance during preload reduction with progressive upright tilt that are relevant both for space exploration and the upright posture, particularly the preload dependence of various parameters of cardiovascular performance...
October 19, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29053805/longitudinal-measures-of-deformation-are-associated-with-a-composite-measure-of-contractility-derived-from-pressure-volume-loop-analysis-in-children
#5
Shahryar M Chowdhury, Ryan J Butts, Carolyn L Taylor, Varsha M Bandisode, Karen S Chessa, Anthony M Hlavacek, Arni Nutting, Girish S Shirali, G Hamilton Baker
Aims: The relationship between echocardiographic measures of left ventricular (LV) systolic function and reference-standard measures have not been assessed in children. The objective of this study was to assess the validity of echocardiographic indices of LV systolic function via direct comparison to a novel composite measure of contractility derived from pressure-volume loop (PVL) analysis. Methods and results: Children with normal loading conditions undergoing routine left heart catheterization were prospectively enrolled...
June 29, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29030937/changes-in-blood-volume-indicators-and-dynamic-indicators-measured-with-transpulmonary-ultrasound-velocity-during-blood-depletion-and-repletion-in-a-neonatal-swine-model
#6
Manuel Martin-Flores, Alvaro F Cisternas, Robin D Gleed
BACKGROUND: Dynamic indicators such as pulse pressure and stroke volume variations can be measured to track changes in preload during hemorrhage, and evaluate fluid therapy. However, these dynamic indicators require mechanical ventilation, and might be affected by cardiac dysrhythmias and changes in vascular tone. Blood volume indicators may offer alternatives for assessing changes in volume status. AIMS: The aims of this study were to measure changes in blood volume indicators and dynamic indicators during removal of blood in two stages and subsequent blood replacement in anesthetized, mechanically ventilated, neonatal pigs...
November 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29019299/additional-mechanism-for-left-ventricular-dysfunction-chronic-pulmonary-regurgitation-decreases-left-ventricular-preload-in-patients-with-tetralogy-of-fallot
#7
Pekka Ylitalo, Eero Jokinen, Kirsi Lauerma, Miia Holmström, Olli M Pitkänen-Argillander
BACKGROUND: Right ventricular dysfunction in patients with tetralogy of Fallot and significant pulmonary regurgitation may lead to systolic dysfunction of the left ventricle due to altered ventricular interaction. We were interested in determining whether chronic pulmonary regurgitation affects the preload of the left ventricle. In addition, we wanted to study whether severe chronic pulmonary regurgitation would alter the preload of the left ventricle when compared with patients having preserved pulmonary valve annulus...
October 11, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28984705/the-crashing-patient-hemodynamic-collapse
#8
Hitesh Gidwani, Hernando Gómez
PURPOSE OF REVIEW: Rapid restoration of tissue perfusion and oxygenation are the main goals in the resuscitation of a patient with circulatory collapse. This review will focus on providing an evidence based framework of the technological and conceptual advances in the evaluation and management of the patient with cardiovascular collapse. RECENT FINDINGS: The initial approach to the patient in cardiovascular collapse continues to be based on the Ventilate-Infuse-Pump rule...
December 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28969770/a-ready-to-use-duplex-qpcr-to-detect-leishmania-infantum-dna-in-naturally-infected-dogs
#9
Rita de Cássia Pontello Rampazzo, Manuela da Silva Solcà, Liliane Celestino Sales Santos, Lais de Novaes Pereira, José Carlos Oliveira Guedes, Patrícia Sampaio Tavares Veras, Deborah Bittencourt Mothé Fraga, Marco Aurélio Krieger, Alexandre Dias Tavares Costa
Canine visceral leishmaniasis (CVL) is a systemic disease caused by Leishmania infantum. A precise CVL diagnosis would allow for a faster and more specific treatment. Quantitative PCR (qPCR) is a sensitive and specific technique that can diagnose CVL and also monitor parasite load in the animal during the course of the infection or treatment. The aim of this study was to develop a ready-to-use (gelified and freezer-free) duplex qPCR for the identification of infected animals. We combined a new qPCR protocol that detects the canine 18S rRNA gene with an existing protocol for L...
November 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28968479/biceps-tenodesis-biomechanical-assessment-of-3-arthroscopic-suprapectoral-techniques
#10
George Vestermark, David Hartigan, Dana Piasecki, James Fleischli, Susan M Odum, Nigel Zheng, Donald F D'Alessandro
Biceps tenodesis maintains the cosmetic appearance and length-tension relationship of the biceps with an associated predictable clinical outcome compared with tenotomy. Arthroscopic suprapectoral techniques are being developed to avoid the disadvantages of the open subpectoral approach. This study biomechanically compared 3 arthroscopic suprapectoral biceps tenodesis techniques performed with a suture anchor with lasso loop technique, an interference screw, and a compressive rivet. For a total of 15 randomized paired tests, 15 pairs of human cadaveric shoulders were used to test 1 technique vs another 5 times with 3 customized setups...
October 2, 2017: Orthopedics
https://www.readbyqxmd.com/read/28966921/echocardiographic-evaluation-of-hemodynamics-in-neonates-and-children
#11
REVIEW
Yogen Singh
Hemodynamic instability and inadequate cardiac performance are common in critically ill children. The clinical assessment of hemodynamic status is reliant upon physical examination supported by the clinical signs such as heart rate, blood pressure, capillary refill time, and measurement of the urine output and serum lactate. Unfortunately, all of these parameters are surrogate markers of cardiovascular well-being and they provide limited direct information regarding the adequacy of blood flow and tissue perfusion...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28953197/effect-of-impella-during-veno-arterial-extracorporeal-membrane-oxygenation-on-pulmonary-artery-flow-as-assessed-by-end-tidal-carbon-dioxide
#12
Jacob Eliet, Philippe Gaudard, Norddine Zeroual, Philippe Rouvière, Bernard Albat, Marc Mourad, Pascal H Colson
Peripheral veno-arterial extracorporeal membrane oxygenation (VA ECMO) exposes the patient to a pulmonary blood flow bypass and a left ventricle afterload increase. Impella, a catheter-mounted microaxial rotary pump, has been proposed for left ventricle (LV) unloading in combination with VA ECMO. In order to assess the effect of Impella on pulmonary flow and LV preload, we checked Doppler pulmonary artery velocity-time integral (pVTI) and LV diastolic diameter (LVED) by transesophageal echocardiography and end-tidal carbon dioxide (EtCO2) during a step-by-step increase in Impella flow (Impella ramp test)...
September 25, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28938032/efficacy-of-sealing-agents-on-preload-maintenance-of-screw-retained-implant-supported-prostheses
#13
Camila Berbel Seloto, Henrico Badaoui Strazzi Sahyon, Paulo Henrique Dos Santos, Juliana Aparecida Delben, Wirley Gonçalves Assunção
PURPOSE: The aim of this study was to evaluate the effect of sealing agents on preload maintenance of screw joints. MATERIALS AND METHODS: A total of four groups (n = 10 in each group) of abutment/implant systems, including external hexagon implants and antirotational UCLA abutments with a metallic collar in cobalt-chromium alloy, were assessed. In the control group (CG), no sealing agent was used at the abutment screw/implant interface. In the other groups, three different sealing agents were used at the abutment screw/implant interface: anaerobic sealing agent for medium torque (ASMT), anaerobic sealing agent for high torque (ASHT), and cyanoacrylate-based bonding agent (CYAB)...
September 22, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28937241/preejection-period-as-a-sympathetic-activity-index-a-role-of-confounding-factors
#14
J Krohova, B Czippelova, Z Turianikova, Z Lazarova, I Tonhajzerova, M Javorka
In previous studies, one of the systolic time intervals - preejection period (PEP) - was used as an index of sympathetic activity reflecting the cardiac contractility. However, PEP could be also influenced by several other cardiovascular variables including preload, afterload and diastolic blood pressure (DBP). The aim of this study was to assess the behavior of the PEP together with other potentially confounding cardiovascular system characteristics in healthy humans during mental and orthostatic stress (head-up tilt test - HUT)...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28934895/high-early-fluid-input-after-aneurysmal-subarachnoid-hemorrhage-combined-report-of-association-with-delayed-cerebral-ischemia-and-feasibility-of-cardiac-output-guided-fluid-restriction
#15
Leonie J M Vergouw, Mohamud Egal, Bas Bergmans, Diederik W J Dippel, Hester F Lingsma, Mervyn D I Vergouwen, Peter W A Willems, Annemarie W Oldenbeuving, Jan Bakker, Mathieu van der Jagt
BACKGROUND: Guidelines on the management of aneurysmal subarachnoid hemorrhage (aSAH) recommend euvolemia, whereas hypervolemia may cause harm. We investigated whether high early fluid input is associated with delayed cerebral ischemia (DCI), and if fluid input can be safely decreased using transpulmonary thermodilution (TPT). METHODS: We retrospectively included aSAH patients treated at an academic intensive care unit (2007-2011; cohort 1) or managed with TPT (2011-2013; cohort 2)...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28895094/fluid-loading-and-norepinephrine-infusion-mask-the-left-ventricular-preload-decrease-induced-by-pleural-effusion
#16
Kristian Borup Wemmelund, Viktor Kromann Ringgård, Simon Tilma Vistisen, Janus Adler Hyldebrandt, Erik Sloth, Peter Juhl-Olsen
BACKGROUND: Pleural effusion (PLE) may lead to low blood pressure and reduced cardiac output. Low blood pressure and reduced cardiac output are often treated with fluid loading and vasopressors. This study aimed to determine the impact of fluid loading and norepinephrine infusion on physiologic determinants of cardiac function obtained by ultrasonography during PLE. METHODS: In this randomised, blinded, controlled laboratory study, 30 piglets (21.9 ± 1.3 kg) had bilateral PLE (75 mL/kg) induced...
September 11, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28888229/changes-in-ankle-joint-motion-after-supramalleolar-osteotomy-a-cadaveric-model
#17
Hak Jun Kim, Eui Dong Yeo, Im Joo Rhyu, Soon-Hyuck Lee, Yeon Soo Lee, Young Koo Lee
BACKGROUND: Malalignment of the ankle joint has been found after trauma, by neurological disorders, genetic predisposition and other unidentified factors, and results in asymmetrical joint loading. For a medial open wedge supramalleolar osteotomy(SMO), there are some debates as to whether concurrent fibular osteotomy should be performed. We assessed the changes in motion of ankle joint and plantar pressure after supramalleolar osteotomy without fibular osteotomy. METHODS: Ten lower leg specimens below the knee were prepared from fresh-frozen human cadavers...
September 9, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28874030/synergistic-effects-of-remote-perconditioning-with-terminal-blood-cardioplegia-in-an-in-vivo-piglet-model
#18
Takayuki Abe, Kiyozo Morita, Gen Shinohara, Kazuhiro Hashimoto, Masako Nishikawa
OBJECTIVES: This study tested the hypothesis that remote perconditioning offers effective and synergistic cardioprotection to terminal warm blood cardioplegia for prompt ventricular recovery after prolonged cardioplegic arrest in an in vivo piglet model. METHODS: Twenty-four piglets were subjected to 120 min of single-dose cardioplegic arrest and were divided into 4 groups according to the mode of reperfusion: control (simple aortic unclamp), remote perconditioning, terminal warm blood cardioplegia or remote perconditioning + terminal warm blood cardioplegia; remote perconditioning (4 cycles of 5-min ischaemia-reperfusion of the lower limb) was applied prior to aortic unclamping...
September 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28870473/short-term-effects-of-a-low-glycemic-index-carob-containing-snack-on-energy-intake-satiety-and-glycemic-response-in-normal-weight-healthy-adults-results-from-two-randomized-trials
#19
Emilia Papakonstantinou, Nickolaos Orfanakos, Paul Farajian, Anastasia E Kapetanakou, Ifigenia P Makariti, Nikolaos Grivokostopoulos, Marie-Ann Ha, Panagiotis N Skandamis
OBJECTIVES: The potential positive health effects of carob-containing snacks are largely unknown. Therefore, the aims of these studies were to determine the glycemic index (GI) of a carob snack compared with chocolate cookie containing equal amounts of available carbohydrates and to compare the effects of a carob versus chocolate cookie preload consumed as snack before a meal on (a) short-term satiety response measured by subsequent ad libitum meal intake, (b) subjective satiety as assessed by visual analog scales and (c) postprandial glycemic response...
October 2017: Nutrition
https://www.readbyqxmd.com/read/28867649/synthesis-and-characterization-of-arginine-nipaam-hybrid-hydrogel-as-wound-dressing-in-vitro-and-in-vivo-study
#20
De-Qun Wu, Jie Zhu, Hua Han, Jun-Zhi Zhang, Fei-Fei Wu, Xiao-Hong Qin, Jian-Yong Yu
A multi-functional hybrid hydrogel P(M-Arg/NIPAAm) with temperature response, anti-protein adsorption and antibacterial properties was prepared and applied as wound dressing. The hydrogel was carried out by free radical copolymerization of methacrylate arginine (M-Arg) and N-isopropyl acrylamide (NIPAAm) monomers using N, N'-methylene bisacrylamide as a crosslinker, and ammonium persulfate/N, N, N', N'-tetramethylethylenediamine as the redox initiator. To endow the antimicrobial property, chlorhexidine diacetate (CHX) was preloaded into the hydrogel and polyhexamethylene guanidine phosphate (PHMG) was grafted on the hydrogel surface, respectively...
August 31, 2017: Acta Biomaterialia
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