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https://www.readbyqxmd.com/read/27877133/decomposition-of-near-infrared-spectroscopy-signals-using-oblique-subspace-projections-applications-in-brain-hemodynamic-monitoring
#1
Alexander Caicedo, Carolina Varon, Borbala Hunyadi, Maria Papademetriou, Ilias Tachtsidis, Sabine Van Huffel
Clinical data is comprised by a large number of synchronously collected biomedical signals that are measured at different locations. Deciphering the interrelationships of these signals can yield important information about their dependence providing some useful clinical diagnostic data. For instance, by computing the coupling between Near-Infrared Spectroscopy signals (NIRS) and systemic variables the status of the hemodynamic regulation mechanisms can be assessed. In this paper we introduce an algorithm for the decomposition of NIRS signals into additive components...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27862979/cerebral-tissue-oxygenation-index-and-lactate-at-24-hours-postoperative-predict-survival-and-neurodevelopmental-outcome-after-neonatal-cardiac-surgery
#2
Safwat A Aly, David Zurakowski, Penny Glass, Kami Skurow-Todd, Richard A Jonas, Mary T Donofrio
IMPORTANCE: There are no well-established noninvasive biomarkers for identifying patients at risk for poor outcome after surgery for congenital heart disease. Few studies have assessed prognostic accuracy of cerebral tissue oxygenation index (cTOI) measured by near infrared spectroscopy (NIRS). OBJECTIVE: To assess the utility of noninvasive NIRS monitoring as a predictor of outcomes after neonatal cardiac surgery through measurement of cTOI. To examine the utility of noninvasive NIRS monitoring in combination with lactate concentration and inotropic score in prediction of outcomes after neonatal cardiac surgery...
November 10, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27741177/antenatal-corticosteroids-and-outcomes-of-small-for-gestational-age-neonates
#3
Nir Melamed, Alex Pittini, Jon Barrett, Jyotsna Shah, Eugene W Yoon, Brigitte Lemyre, Shoo K Lee, Kellie E Murphy, Prakesh S Shah
OBJECTIVE: To assess the association of antenatal corticosteroids and neonatal outcomes of preterm small-for-gestational-age (SGA) neonates and estimate whether the association is similar to that observed in appropriate-for-gestational-age (AGA) neonates. METHODS: We conducted a retrospective cohort study using data collected on singleton neonates born between 24 0/7 and 33 6/7 weeks of gestation and admitted to tertiary neonatal units in Canada between 2010 and 2014...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27699112/continuous-cerebral-hemodynamic-measurement-during-deep-hypothermic-circulatory-arrest
#4
David R Busch, Craig G Rusin, Wanda Miller-Hance, Kathy Kibler, Wesley B Baker, Jeffrey S Heinle, Charles D Fraser, Arjun G Yodh, Daniel J Licht, Kenneth M Brady
While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement...
September 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27526141/interrelationship-between-broadband-nirs-measurements-of-cerebral-cytochrome-c-oxidase-and-systemic-changes-indicates-injury-severity-in-neonatal-encephalopathy
#5
Gemma Bale, Subhabrata Mitra, Isabel de Roever, Marcus Chan, Alexander Caicedo-Dorado, Judith Meek, Nicola Robertson, Ilias Tachtsidis
Perinatal hypoxic ischaemic encephalopathy (HIE) is associated with severe neurodevelopmental problems and mortality. There is a clinical need for techniques to provide cotside assessment of the injury extent. This study aims to use non-invasive cerebral broadband near-infrared spectroscopy (NIRS) in combination with systemic physiology to assess the severity of HIE injury. Broadband NIRS is used to measure the changes in haemodynamics, oxygenation and the oxidation state of cytochrome c oxidase (oxCCO). We used canonical correlation analysis (CCA), a multivariate statistical technique, to measure the relationship between cerebral broadband NIRS measurements and systemic physiology...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27526136/changes-in-oxygenation-levels-precede-changes-in-amplitude-of-the-eeg-in-premature-infants
#6
Alexander Caicedo, Liesbeth Thewissen, Anne Smits, Gunnar Naulaers, Karel Allegaert, Sabine Van Huffel
Brain function is supported by an appropriate balance between the metabolic demand and the supply of nutrients and oxygen. However, the physiological principles behind the regulation of brain metabolism and demand in premature infants are unknown. Some studies found that changes in hemodynamic variables in this population precede changes in EEG activity; however, these studies only used descriptive statistics. This paper describes the relationship between changes in cerebral oxygenation, assessed by means of near-infrared spectroscopy (NIRS), and changes in EEG, using mathematical methods taken from information dynamics...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27467111/splanchnic-oxygenation-at-first-enteral-feeding-in-preterm-infants-correlation-with-feeding-intolerance
#7
Luigi Corvaglia, Silvia Martini, Barbara Battistini, Paola Rucci, Giacomo Faldella, Arianna Aceti
Preterm infants are at risk of developing gastrointestinal complications such as feeding intolerance (FI) and necrotizing enterocolitis. Near-infrared spectroscopy (NIRS) provides continuous monitoring of abdominal oxygenation (ArSO2) and could help to predict gastrointestinal complications in preterm neonates. In this prospective observational study, ArSO2 patterns at first enteral feed were evaluated by NIRS in 61 clinically stable preterm infants. Splanchnic-cerebral oxygenation ratio (SCOR), which is a marker of gut hypoxia, was also calculated...
June 21, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27420164/sucrose-for-analgesia-in-newborn-infants-undergoing-painful-procedures
#8
REVIEW
Bonnie Stevens, Janet Yamada, Arne Ohlsson, Sarah Haliburton, Allyson Shorkey
BACKGROUND: Administration of oral sucrose with and without non-nutritive sucking is the most frequently studied non-pharmacological intervention for procedural pain relief in neonates. OBJECTIVES: To determine the efficacy, effect of dose, method of administration and safety of sucrose for relieving procedural pain in neonates as assessed by validated composite pain scores, physiological pain indicators (heart rate, respiratory rate, saturation of peripheral oxygen in the blood, transcutaneous oxygen and carbon dioxide (gas exchange measured across the skin - TcpO2, TcpCO2), near infrared spectroscopy (NIRS), electroencephalogram (EEG), or behavioural pain indicators (cry duration, proportion of time crying, proportion of time facial actions (e...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27400016/outcomes-of-pregnancies-complicated-by-preterm-premature-rupture-of-membranes-between-20-and-24-weeks-of-gestation
#9
Mia Kibel, Elizabeth Asztalos, Jon Barrett, Michael S Dunn, Carly Tward, Alex Pittini, Nir Melamed
OBJECTIVE: To assess the natural history and contemporary outcomes in pregnancies complicated by previable preterm premature rupture of membranes (PROM). METHODS: Retrospective study of all women with a singleton or twin pregnancy admitted to a single tertiary referral center who experienced preterm PROM between 20 and 23 6/7 weeks of gestation during 2004-2014 and underwent expectant management. Women electing termination of pregnancy and pregnancies complicated by major fetal anomalies were excluded...
August 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27291495/t2-prepared-velocity-selective-labelling-a-novel-idea-for-full-brain-mapping-of-oxygen-saturation
#10
Thomas Alderliesten, Jill B De Vis, Petra M A Lemmers, Frank van Bel, Manon J N L Benders, Jeroen Hendrikse, Esben T Petersen
BACKGROUND AND AIM: Disturbances in cerebral oxygenation saturation (SO2) have been linked to adverse outcome in adults, children, and neonates. In intensive care, the cerebral SO2 is increasingly being monitored by Near-InfraRed Spectroscopy (NIRS). Unfortunately NIRS has a limited penetration depth. The "modified T2-prepared Blood Imaging of Oxygen Saturation" (T2-BIOS) MR sequence provides a step towards full brain SO2 measurement. MATERIALS AND METHODS: tissue SO2, and venous SO2 (SvO2) were obtained simultaneously by T2-BIOS during a respiratory challenge in ten healthy volunteers...
June 9, 2016: NeuroImage
https://www.readbyqxmd.com/read/27260974/the-role-of-antenatal-corticosteroids-in-twin-pregnancies-complicated-by-preterm-birth
#11
Nir Melamed, Jyotsna Shah, Eugene W Yoon, Ermelinda Pelausa, Shoo K Lee, Prakesh S Shah, Kellie E Murphy
BACKGROUND: Data regarding the effects of antenatal corticosteroids in twin pregnancies are limited because of the insufficient number of women with twins enrolled in randomized controlled trials on antenatal corticosteroids. Furthermore, the interpretation of available data is limited by the fact that the interval from the administration of antenatal corticosteroids to delivery is greater than 7 days in a large proportion of twins, a factor that has been shown to affect the efficacy of antenatal corticosteroids and has not been controlled for in previous studies...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27206637/near-infrared-spectroscopy-the-new-must-have-tool-in-the-intensive-care-unit
#12
REVIEW
Michael Stuart Green, Sankalp Sehgal, Rayhan Tariq
Standard hemodynamic monitoring such as blood pressure and pulse oximetry may only provide a crude estimation of organ perfusion in the critical care setting. Near-infrared spectroscopy (NIRS) is based on the same principle as a pulse oximeter and allows continuous noninvasive monitoring of hemoglobin oxygenation and deoxygenation and thus tissue saturation "StO2" This review aims to provide an overview of NIRS technology principles and discuss its current clinical use in the critical care setting. The study selection was performed using the PubMed database to find studies that investigated the use of NIRS in both the critical care setting and in the intensive care unit...
September 2016: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27083278/pregnancy-across-the-spectrum-of-chronic-kidney-disease
#13
REVIEW
Michelle A Hladunewich, Nir Melamad, Kate Bramham
Management of the pregnant woman with chronic kidney disease is difficult for both nephrologists and obstetricians. Prepregnancy counselling with respect to risk stratification, optimization of maternal health prior to pregnancy, as well as management of the many potential pregnancy-associated complications in this complex patient population remains challenging due to the paucity of large, well-designed clinical studies. Furthermore, the heterogeneity of disease and the relative infrequency of pregnancy, particularly in more advanced stages of chronic kidney disease, leaves many clinicians feeling ill prepared to manage these pregnancies...
May 2016: Kidney International
https://www.readbyqxmd.com/read/27039154/low-cerebral-activity-and-cerebral-oxygenation-during-immediate-transition-in-term-neonates-a-prospective-observational-study
#14
Anna Tamussino, Berndt Urlesberger, Nariae Baik, Bernhard Schwaberger, Corinna Binder-Heschl, Georg M Schmölzer, Alexander Avian, Gerhard Pichler
AIM: To analyze whether in term neonates during immediate transition after birth low cerebral activity measured by amplitude-integrated EEG (aEEG) is linked to cerebral regional oxygen saturation (crSO2) measured by near-infrared spectroscopy (NIRS). Additionally, the cerebral fractional tissue oxygen extraction (cFTOE) was calculated to analyze whether cerebral activity is linked to cFTOE. METHODS: A total of 244 term neonates delivered by primary cesarean section were studied...
June 2016: Resuscitation
https://www.readbyqxmd.com/read/26998592/classifying-neonatal-growth-outcomes-use-of-birth-weight-placental-evaluation-and-individualized-growth-assessment
#15
Russell L Deter, Khrystyna Levytska, Nir Melamed, Wesley Lee, John C P Kingdom
OBJECTIVE: To compare neonatal growth outcomes determined by birth weight (BW), placental assessment (Plac Assess) and individualized growth assessment (IGA). METHODS: This retrospective analysis was carried out in 45 selected pregnancies at risk for fetal growth restriction. Serial fetal biometry was carried out in the 2nd and 3rd trimester. First and second trimester placental biomarkers, 2nd trimester uterine artery (Ut A) velocimetry and postnatal placental pathology were evaluated as indicators of placental insufficiency...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26957401/postoperative-abdominal-nirs-values-predict-low-cardiac-output-syndrome-in-neonates
#16
Rhiannon L Hickok, Michael C Spaeder, John T Berger, Jennifer J Schuette, Darren Klugman
BACKGROUND: The development of low cardiac output syndrome (LCOS) after cardiopulmonary bypass (CPB) occurs in up to 25% of neonates and is associated with increased morbidity. Invasive cardiac output monitors such as pulmonary artery catheters have limited availability and are costly. Near-infrared spectroscopy (NIRS) is a noninvasive tool for monitoring regional oxygenation in neonates in the cardiac intensive care unit (CICU). We hypothesize that anterior abdominal NIRS may aid in the early identification of LCOS after cardiac surgery...
March 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/26942906/prediction-of-small-for-gestational-age-accuracy-of-different-sonographic-fetal-weight-estimation-formulas
#17
Rinat Gabbay-Benziv, Amir Aviram, Ron Bardin, Eran Ashwal, Nir Melamed, Liran Hiersch, Arnon Wiznitzer, Yariv Yogev, Eran Hadar
OBJECTIVE: To compare the accuracy of various sonographic estimated fetal weight (sEFW) formulas for the prediction of small for gestational age (SGA) neonates. METHODS: A retrospective analysis of 6,126 fetal biometrical measurements performed within 3 days of delivery. SGA prediction was evaluated for various sEFW formulas by calculating the sensitivity, specificity, positive/negative predictive value (PPV/NPV), likelihood ratio (+LR/-LR), overall accuracy and area under the receiver operating characteristic curve (AUC)...
March 5, 2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/26928149/induction-of-labor-before-40-weeks-is-associated-with-lower-rate-of-cesarean-delivery-in-women-with-gestational-diabetes-mellitus
#18
COMPARATIVE STUDY
Nir Melamed, Joel G Ray, Michael Geary, Daniel Bedard, Cathy Yang, Ann Sprague, Beth Murray-Davis, Jon Barrett, Howard Berger
BACKGROUND: In women with gestational diabetes mellitus, it is not clear whether routine induction of labor at <40 weeks of gestation is beneficial to mother and newborn infant. OBJECTIVE: The purpose of this study was to compare outcomes among women with gestational diabetes mellitus who had induction of labor at either 38 or 39 weeks with those whose pregnancy was managed expectantly. STUDY DESIGN: We included all women in Ontario, Canada, with diagnosed gestational diabetes mellitus who had a singleton hospital birth at ≥38 + 0 weeks of gestation between April 2012 and March 2014...
March 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26906178/which-anthropometric-measure-best-correlates-with-neonatal-fat-mass-at-birth
#19
Gal Dubnov-Raz, Moran Gal, Yeela Landau-Helman, Lihi Biderman, Romy Nir, Ayala Maayan-Metzger
Objective Body composition provides additional information than weight alone. There is currently no accepted anthropometric measure of adiposity in infants, yet weight and length data allow calculations of a wide array of indices. The study objective was to identify the anthropometric index which best correlates with neonatal adiposity, by examining the associations between neonatal fat mass and several anthropometric indices of newborn infants. Study Design The sum of skinfolds (SSF), birth weight, and birth length were measured in 94 healthy infants (58% males) born at term to healthy mothers...
July 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/26782252/characterizing-fluctuations-of-arterial-and-cerebral-tissue-oxygenation-in-preterm-neonates-by-means-of-data-analysis-techniques-for-nonlinear-dynamical-systems
#20
Stefan Kleiser, Marcin Pastewski, Tharindi Hapuarachchi, Cornelia Hagmann, Jean-Claude Fauchère, Ilias Tachtsidis, Martin Wolf, Felix Scholkmann
The cerebral autoregulatory state as well as fluctuations in arterial (SpO2) and cerebral tissue oxygen saturation (StO2) are potentially new relevant clinical parameters in preterm neonates. The aim of the present study was to test the investigative capabilities of data analysis techniques for nonlinear dynamical systems, looking at fluctuations and their interdependence. StO2, SpO2 and the heart rate (HR) were measured on four preterm neonates for several hours. The fractional tissue oxygenation extraction (FTOE) was calculated...
2016: Advances in Experimental Medicine and Biology
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