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https://www.readbyqxmd.com/read/29137806/a-novel-multimodal-computational-system-using-near-infrared-spectroscopy-predicts-the-need-for-ecmo-initiation-in-neonates-with-congenital-diaphragmatic-hernia
#1
Stephanie M Cruz, Patricio E Lau, Craig G Rusin, Candace C Style, Darrell L Cass, Caraciolo J Fernandes, Timothy C Lee, Christopher J Rhee, Sundeep Keswani, Rodrigo Ruano, Stephen E Welty, Oluyinka O Olutoye
BACKGROUND/PURPOSE: The purpose of this study was to develop a computational algorithm that would predict the need for ECMO in neonates with congenital diaphragmatic hernia (CDH). METHODS: CDH patients from August 2010 to 2016 were enrolled in a study to continuously measure cerebral tissue oxygen saturation (cStO2) of left and right cerebral hemispheres. NIRS devices utilized were FORE-SIGHT, CASMED and INVOS 5100, Somanetics. Using MATLAB©, a data randomization function was used to deidentify and blindly group patient's data files as follows: 12 for the computational model development phase (6 ECMO and 6 non-ECMO) and the remaining patients for the validation phase...
October 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29131125/splanchnic-cerebral-oxygenation-ratio-decreases-during-enteral-feedings-in-anemic-preterm-infants-observations-under-near-infrared-spectroscopy
#2
Katherine Braski, Kimberlee Weaver-Lewis, Manndi Loertscher, Qian Ding, Xiaoming Sheng, Mariana Baserga
BACKGROUND: Anemia is common in premature infants. Due to risks with red blood cell transfusions, many anemic infants are not transfused. The implications of this pathophysiologic status, especially at times of increased metabolic demand (enteral feedings), is not well understood. Near-infrared spectroscopy (NIRS) allows for the noninvasive determination of regional oxygen saturations (rSO2) in tissues such as the brain and mesentery, giving insight into their oxygen sufficiency. OBJECTIVE: We tested the hypothesis that during enteral feedings very low birth weight (VLBW) infants with a hematocrit ≤28% will experience a decrease in splanchnic rSO2 and splanchnic-cerebral oxygenation ratio (SCOR)...
November 8, 2017: Neonatology
https://www.readbyqxmd.com/read/28981572/spinal-anaesthesia-in-neonates-and-infants-what-about-the-cerebral-oxygen-saturation
#3
C Sola, L Hertz, S Bringuier, P De La Arena, C Macq, S Deziel-Malouin, O Raux, C Dadure
Background: Spinal Anaesthesia (SA) has been firmly established as an efficient and safe technique, with minimal cardio-respiratory disturbance when administered in the neonatal period. Our objective was to assess the haemodynamic consequences of SA in infants, particularly its impact on cerebral perfusion using near-infrared spectroscopy (NIRS)-based cerebral oximetry (rSco2). Methods: All infants up to 60 weeks' postmenstrual age, whether formerly preterm or not, and undergoing spinal anaesthesia, were enrolled...
November 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28963396/a-novel-microglial-subset-plays-a-key-role-in-myelinogenesis-in-developing-brain
#4
Agnieszka Wlodarczyk, Inge R Holtman, Martin Krueger, Nir Yogev, Julia Bruttger, Reza Khorooshi, Anouk Benmamar-Badel, Jelkje J de Boer-Bergsma, Nellie A Martin, Khalad Karram, Isabella Kramer, Erik Wgm Boddeke, Ari Waisman, Bart Jl Eggen, Trevor Owens
Microglia are resident macrophages of the central nervous system that contribute to homeostasis and neuroinflammation. Although known to play an important role in brain development, their exact function has not been fully described. Here, we show that in contrast to healthy adult and inflammation-activated cells, neonatal microglia show a unique myelinogenic and neurogenic phenotype. A CD11c(+) microglial subset that predominates in primary myelinating areas of the developing brain expresses genes for neuronal and glial survival, migration, and differentiation...
September 28, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28960522/near-infrared-spectroscopy-is-a-promising-noninvasive-technique-for-monitoring-the-effects-of-feeding-regimens-on-the-cerebral-and-splanchnic-regions
#5
Alice Grometto, Benedetta Pizzo, Maria Chiara Strozzi, Francesca Gazzolo, Diego Gazzolo
AIM: The effects of different milk and, or, administration regimens on cerebro-splanchnic perfusion are still a matter of debate. We investigated the effects of the bolus administration of breast milk or formula on cerebro-splanchnic oximetry, function and perfusion, assessed by near-infrared spectroscopy (NIRS). METHODS: This observational study of 30 infants fed with breast (n = 15) or formula (n = 15) milk, and matched for gestational age and birth weight, was carried out in the neonatal intensive care unit of the C Arrigo Children's Hospital, Alessandria, Italy, a tertiary-level referral centre, from October 2015 to December 2016...
September 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28958087/neonatal-sleep-wake-analyses-predict-18-month-neurodevelopmental-outcomes
#6
R A Shellhaas, J W Burns, F Hassan, M D Carlson, J D E Barks, R D Chervin
Objectives: The neurological examination of critically ill neonates is largely limited to reflexive behavior. The exam often ignores sleep-wake physiology that may reflect brain integrity and influence long-term outcomes. We assessed whether polysomnography and concurrent cerebral near-infrared spectroscopy (NIRS) might improve prediction of 18-month neurodevelopmental outcomes. Methods: Term newborns with suspected seizures underwent standardized neurologic examinations to generate Thompson scores, and had 12-hour bedside polysomnography with concurrent cerebral NIRS...
August 29, 2017: Sleep
https://www.readbyqxmd.com/read/28869278/cerebral-near-infrared-spectroscopy-monitoring-for-prevention-of-brain-injury-in-very-preterm-infants
#7
REVIEW
Simon Hyttel-Sorensen, Gorm Greisen, Bodil Als-Nielsen, Christian Gluud
BACKGROUND: Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants. Cerebral near-infrared spectroscopy (NIRS) enables continuous estimation of cerebral oxygenation. This diagnostic method coupled with appropriate interventions if NIRS is out of normal range (that is cerebral oxygenation within the 55% to 85% range) may offer benefits without causing more harms. Therefore, NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of randomised clinical trials and quasi-randomised studies...
September 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28856710/cerebral-oxygenation-measured-by-near-infrared-spectroscopy-correlates-with-arterial-oxygenation-only-poorly-in-preterm-infants-a-strength-of-that-technology
#8
Berndt Urlesberger, Gerhard Pichler
We read with interest the article by Hunter et al, titled "Cerebral oxygenation as measured by near-infrared spectroscopy in neonatal intensive care: correlation with arterial oxygenation". We agree that cerebral oxygenation only correlates poorly with the arterial oxygenation in preterm infants. We do not agree with the authors conclusions that this is a disadvantage of near-infrared spectroscopy (NIRS) and that "strong correlation between rScO2 and ABG parameters such as SaO2, SpO2 and PaCO2 would have provided more clinically meaningful implications...
August 30, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28840165/in-vivo-measure-of-neonate-brain-optical-properties-and-hemodynamic-parameters-by-time-domain-near-infrared-spectroscopy
#9
Lorenzo Spinelli, Lucia Zucchelli, Davide Contini, Matteo Caffini, Jacques Mehler, Ana Fló, Alissa L Ferry, Luca Filippin, Francesco Macagno, Luigi Cattarossi, Alessandro Torricelli
By exploiting a multichannel portable instrument for time-domain near-infrared spectroscopy (TD-NIRS), we characterized healthy neonates' brains in term of optical properties and hemodynamic parameters. In particular, we assessed the absolute values of the absorption and reduced scattering coefficients at two wavelengths, together with oxy-, deoxy- and total hemoglobin concentrations, and the blood oxygen saturation of the neonates' brains. In this study, 33 healthy full-term neonates were tested, obtaining the following median values: 0...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/28823017/near-infrared-spectroscopy-monitoring-during-immediate-transition-after-birth-time-to-obtain-cerebral-tissue-oxygenation
#10
Evelyn Ziehenberger, Berndt Urlesberger, Corinna Binder-Heschl, Bernhard Schwaberger, Nariae Baik-Schneditz, Gerhard Pichler
Feasibility of cerebral tissue oxygenation measurements immediately after birth has been published starting with first values 2 min after birth. Aim of this study was to evaluate, the time periods from birth and from arrival at the resuscitation table to obtain the first cerebral tissue oxygenation values with two different near infrared spectroscopy (NIRS) devices. The present study is an analysis of exploratory parameters of two prospective observational studies. Cerebral tissue oxygen saturation was measured by the NIRO 200NX measuring "cerebral-tissue-oxygenation-index" (cTOI) or the INVOS5100C measuring "cerebral-regional-oxygen-saturation" (crSO2)...
August 19, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28796691/neonatal-outcomes-of-low-risk-late-preterm-twins-compared-with-late-preterm-singletons
#11
COMPARATIVE STUDY
Shimrit Yaniv Salem, Mia Kibel, Elizabeth Asztalos, Arthur Zaltz, Jon Barrett, Nir Melamed
OBJECTIVE: To test the hypothesis that the risk of neonatal morbidity among late-preterm twins is similar to that of late-preterm singletons. METHODS: We conducted a retrospective cohort study of all women with twin or singleton pregnancy who gave birth during the late-preterm period in a single tertiary center between 2008 and 2015. Neonatal outcomes of low-risk, late-preterm twins were compared with those of low-risk, late-preterm singletons. The primary outcome was the same primary composite respiratory morbidity variable that was used in the randomized controlled trial of Gyamfi-Bannerman et al on the administration of antenatal corticosteroids during the late-preterm period...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28764821/investigating-the-role-of-near-infrared-spectroscopy-in-neonatal-medicine
#12
Kaylee M Evans, Lori B Rubarth
Near-infrared spectroscopy (NIRS) is a clinical tool that provides a bedside method of noninvasively measuring continuous, "real-time" oxygen consumption and monitoring for potential ischemia of somatic tissues, particularly the brain, kidneys, and intestine in neonates. Although the concept of NIRS seems promising, its implementation into clinical practice has been inconsistent for various reasons, including difficulty in interpreting regional oxygen saturation (rSO2), the wide variation in types of NIRS monitors and probes, the cost of new equipment, different monitoring modalities, large discrepancies in both intra- and interindividual use, a lack of defined universal normative values, and little to no data on outcomes or potentially harmful interventions made based on rSO2 readings...
July 1, 2017: Neonatal Network: NN
https://www.readbyqxmd.com/read/28704822/prediction-of-outcome-in-neonates-with-hypoxic-ischemic-encephalopathy-ii-role-of-amplitude-integrated-electroencephalography-and-cerebral-oxygen-saturation-measured-by-near-infrared-spectroscopy
#13
Katharina Goeral, Berndt Urlesberger, Vito Giordano, Gregor Kasprian, Michael Wagner, Lisa Schmidt, Angelika Berger, Katrin Klebermass-Schrehof, Monika Olischar
BACKGROUND: Few data have been published on the combined use of amplitude-integrated electroencephalography (aEEG) and near-infrared spectroscopy (NIRS) for outcome prediction in neonates cooled for hypoxic-ischemic encephalopathy (HIE). OBJECTIVE: Our aim was to evaluate the predictive values and the most powerful predictive combinations of single aEEG and NIRS parameters and the respective cut-off values with regard to short-term outcomes in HIE II. METHODS: aEEG and NIRS were prospectively studied at the Medical University of Vienna in the first 102 h of life with regard to magnetic resonance imaging (MRI)...
2017: Neonatology
https://www.readbyqxmd.com/read/28685437/relation-between-eeg-activity-and-brain-oxygenation-in-preterm-neonates
#14
Alexander Caicedo, Liesbeth Thewissen, Anne Smits, Gunnar Naulaers, Karel Allegaert, Sabine Van Huffel
This study investigates the relationship between brain oxygenation, assessed by means of near infrared spectroscopy (NIRS), and brain function, assessed by means of electroencephalography (EEG). Using NIRS signals measuring the regional cerebral oxygen saturation (rScO2) and computing the fractional tissue oxygen extraction (FTOE), we compared how these variables relate to different features extracted from the EEG, such as the inter-burst interval (IBI) duration and amplitude, the amplitude of the EEG, and the amplitude of the burst...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28665923/noninvasive-continuous-cardiac-output-and-cerebral-perfusion-monitoring-in-term-infants-with-neonatal-encephalopathy-assessment-of-feasibility-and-reliability
#15
Eva Forman, Colm R Breatnach, Stephanie Ryan, Jana Semberova, Jan Miletin, Adrienne Foran, Afif El-Khuffash
BackgroundNoninvasive hemodynamic monitoring of infants with neonatal encephalopathy (NE) undergoing therapeutic hypothermia (TH) would be a potentially useful clinical tool. We aimed to assess the feasibility and reliability of noninvasive cardiac output monitoring (NICOM) and near-infrared spectroscopy (NIRS) in this cohort.MethodsNICOM and NIRS were commenced to measure cardiac output (CO), systemic vascular resistance (SVR), blood pressure (BP), and cerebral regional oxygen saturations (SctO2) during TH and rewarming...
November 2017: Pediatric Research
https://www.readbyqxmd.com/read/28660179/monitoring-cerebral-and-renal-oxygenation-status-during-neonatal-digestive-surgeries-using-near-infrared-spectroscopy
#16
Jonathan Beck, Gauthier Loron, Claire Masson, Marie-Laurence Poli-Merol, Eliane Guyot, Camille Guillot, Nathalie Bednarek, Caroline François
BACKGROUND: Depending on the initial pathology, hypovolemia, intra-abdominal hypertension, and sepsis are often encountered in neonatal digestive surgery. Accurate newborn monitoring during and after surgery is essential to adapt resuscitation protocols. Near infrared spectroscopy (NIRS) is non-invasive and can detect hypoperfusion which indicates a low circulatory blood flow, regardless of the cause. OBJECTIVE: Evaluating changes in cerebral and renal regional oxygen saturation during neonatal digestive surgeries, conducted according to normal practices, with commonly used monitoring parameters...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28643877/cerebral-haemodynamic-response-to-somatosensory-stimulation-in-neonatal-lambs
#17
Shinji Nakamura, David W Walker, Flora Y Wong
KEY POINTS: Cerebral haemodynamic response to neural stimulation has been extensively studied in adults, but little is known about cerebral haemodynamic response in the fetal and neonatal brain. The present study describes the cerebral haemodynamic response measured by near infrared spectroscopy to somatosensory stimulation in newborn lambs, in comparison to recent findings in fetal sheep. The cerebral haemodynamic responses in the newborn lamb brain can involve an increase in oxyhaemoglobin (oxyHb), or a decrease of oxyHb suggestive of reduced perfusion and oxygenation...
September 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28599970/cerebral-near-infrared-spectroscopy-insensitively-detects-low-cerebral-venous-oxygen-saturations-after-stage-1-palliation
#18
Erin Rescoe, Xiaoqi Tang, Dorothy Alison Perry, Lynn A Sleeper, James A DiNardo, Barry D Kussman, John N Kheir
BACKGROUND: Measurement of cerebral venous oxyhemoglobin saturation (ScvO2) is considered a gold standard in assessing the adequacy of tissue oxygen delivery (DO2) after the stage 1 palliation (S1P), with SvO2 <30% often representing severely compromised DO2. Regional oxygenation index (rSO2) based on near-infrared resonance spectroscopy (NIRS) frequently is used to screen for compromised DO2, although its sensitivity to detect severe abnormalities in SvO2 is uncertain. METHODS: ScvO2 was measured by co-oximetry from the internal jugular vein as clinically indicated in 73 neonates after S1P...
September 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28511778/elevated-cranial-ultrasound-resistive-indices-are-associated-with-improved-neurodevelopmental-outcomes-one-year-after-pediatric-cardiac-surgery-a-single-center-pilot-study
#19
Christopher L Jenks, Ana Hernandez, Peter L Stavinoha, Michael C Morris, Fenghua Tian, Hanli Liu, Parvesh Garg, Joseph M Forbess, Joshua Koch
OBJECTIVE: To determine if a non-invasive, repeatable test can be used to predict neurodevelopmental outcomes in patients with congenital heart disease. METHODS: This was a prospective study of pediatric patients less than two months of age undergoing congenital heart surgery at the Children's Health Children's Medical Center at Dallas. Multichannel near-infrared spectroscopy (NIRS) was utilized during the surgery, and ultrasound (US) resistive indices (RI) of the major cranial vessels were obtained prior to surgery, immediately post-operatively, and prior to discharge...
July 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28486365/nonpresenting-dichorionic-twins-and-placental-vascular-malperfusion
#20
Eran Weiner, Michael Kahn, Kristine Giltvedt, Mia Kibel, Christopher Sherman, John Kingdom, Jon Barrett, Nir Melamed
OBJECTIVE: To explore the hypothesis that selective placental pathology affecting the nonpresenting twin is a significant contributory factor mediating the smaller size at birth of nonpresenting dichorionic twins. METHODS: We conducted a retrospective cohort study of all dichorionic twin deliveries in a single tertiary center between 2002 and 2015 where by departmental policy, all placentas from multifetal gestations are routinely sent for pathologic examination...
June 2017: Obstetrics and Gynecology
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