keyword
MENU ▼
Read by QxMD icon Read
search

pantothenic acid

keyword
https://www.readbyqxmd.com/read/28520815/metabolic-profiling-by-gas-chromatography-mass-spectrometry-of-energy-metabolism-in-high-fat-diet-fed-obese-mice
#1
Daxesh P Patel, Kristopher W Krausz, Cen Xie, Diren Beyoğlu, Frank J Gonzalez, Jeffrey R Idle
A novel, selective and sensitive single-ion monitoring (SIM) gas chromatography-mass spectrometry (GCMS) method was developed and validated for the determination of energy metabolites related to glycolysis, the tricarboxylic acid (TCA) cycle, glutaminolysis, and fatty acid β-oxidation. This assay used N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) containing 1% tert-butyldimethylchlorosilane (TBDMCS) as derivatizing reagent and was highly reproducible, sensitive, specific and robust. The assay was used to analyze liver tissue and serum from C57BL/6N obese mice fed a high-fat diet (HFD) and C57BL/6N mice fed normal chow for 8 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28505069/b-vitamin-intake-from-diet-and-supplements-and-breast-cancer-risk-in-middle-aged-women-results-from-the-prospective-nutrinet-sant%C3%A3-cohort
#2
Manon Egnell, Philippine Fassier, Lucie Lécuyer, Laurent Zelek, Marie-Paule Vasson, Serge Hercberg, Paule Latino-Martel, Pilar Galan, Mélanie Deschasaux, Mathilde Touvier
Experimental studies suggest a protective effect of B-vitamins on breast cancer risk, potentially modulated by alcohol intake. However, epidemiological studies are limited, especially regarding non-folate B-vitamins. Furthermore, few studies included quantitative assessment of supplemental intake. This prospective study aimed to investigate the associations between intakes of B-vitamins (dietary, supplemental, total) and breast cancer risk. 27,853 women aged ≥45 years from the NutriNet-Santé cohort (2009-2016) were included, with a median follow-up time of 4...
May 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28501405/short-communication-nutrient-consumption-patterns-of-lactobacillus-acidophilus-klds-1-0738-in-controlled-ph-batch-fermentations
#3
Xuepeng Lv, Gefei Liu, Xiaomei Sun, Hongyu Chen, Jiahui Sun, Zhen Feng
This work focused on elucidating the nutrient consumption patterns of Lactobacillus acidophilus to guide the design of media for high-cell-density culture. We investigated the nutrient consumption patterns of L. acidophilus KLDS 1.0738 in chemically defined media in controlled pH batch fermentations. The most abundantly consumed amino acids, vitamins, ions, and purines and pyrimidines were Glu and Gly, pyridoxine and nicotinamide, K(+) and PO4(3-), and guanine and uracil, respectively. The highest consumption rates for amino acids, vitamins, ions, and purines and pyrimidines were Asp and Arg, folic acid and pyridoxine, Fe(2+) and Mn(2+), and uracil and thymine, respectively...
May 10, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28490678/implications-of-us-nutrition-facts-label-changes-on-micronutrient-density-of-fortified-foods-and-supplements
#4
Michael I McBurney, Sonia Hartunian-Sowa, Nathan V Matusheski
The US FDA published new nutrition-labeling regulations in May 2016. For the first time since the implementation of the Nutrition Labeling and Education Act of 1990, the Daily Value (DV) for most vitamins will change, as will the units of measurement used in nutrition labeling for some vitamins. For some food categories, the Reference Amounts Customarily Consumed (RACCs) will increase to reflect portions commonly consumed on a single occasion. These regulatory changes are now effective, and product label changes will be mandatory beginning 26 July 2018...
May 10, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28489334/diagnosis-of-copan-by-whole-exome-sequencing-waking-up-a-sleeping-tiger-s-eye
#5
Christina Evers, Angelika Seitz, Birgit Assmann, Thomas Opladen, Stephanie Karch, Katrin Hinderhofer, Martin Granzow, Nagarajan Paramasivam, Roland Eils, Nicolle Diessl, Claus R Bartram, Ute Moog
Neurodegeneration with brain iron accumulation (NBIA) is a group of neurodegenerative disorders characterized by iron accumulation in the basal ganglia. Recently, mutations in CoA synthase (COASY) have been identified as a cause of a novel NBIA subtype (COASY Protein-Associated Neurodegeneration, CoPAN) in two patients with dystonic paraparesis, parkinsonian features, cognitive impairment, behavior abnormalities, and axonal neuropathy. COASY encodes an enzyme required for Coenzyme A (CoA) biosynthesis. Using whole exome sequencing (WES) we identified compound heterozygous COASY mutations in two siblings with intellectual disability, ataxic gait, progressive spasticity, and obsessive-compulsive behavior...
May 10, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28458291/similarities-of-water-soluble-vitamin-components-among-non-prescription-pharmaceutical-vitamin-products-generally-available-on-the-domestic-market
#6
Keiichiro Suzuki, Moeko Kojina, Tetsuya Aiba
 Similarities among non-prescription pharmaceutical vitamin products generally available in community pharmacies were examined based on their vitamin components, and a chart was constructed to differentiate products to assist in appropriate product choice. In the analysis of the similarities, two hundred and seventy-six data entries on vitamin products were extracted from the database on the package inserts of the pharmaceutical products provided by the Pharmaceuticals and Medical Devices Agency, and they were reviewed for the amounts of vitamins they contained, in which the B vitamins, or vitamin B1, B2, B6, B12, and niacin, were considered as well as vitamins C and E...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28448444/role-of-the-vanins-myeloperoxidase-axis-in-colorectal-carcinogenesis
#7
REVIEW
Francesco Mariani, Luca Roncucci
The presence of chronic inflammation in the colonic mucosa leads to an increased risk of cancer. Among proteins involved in the regulation of mucosal inflammation and that may contribute both to structural damage of the intestinal mucosa and to intestinal carcinogenesis, there are myeloperoxidase (MPO) and vanins. The infiltration of colonic mucosa by neutrophils may promote carcinogenesis through MPO, a key enzyme contained in the lysosomes of neutrophils that regulates local inflammation and the generation of reactive oxygen species (ROS) and mutagenic species...
April 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28425351/metabolic-changes-in-methomyl-poisoned-rats-treated-by-vitamin-e
#8
J Weng, B Cai, J Chen, B Chen, H Wu, C Wen, F Sun, L Hu, C Chen, X Wang, Z Wang
In this study, we developed a serum and urine metabolomic method based on gas chromatography-mass spectrometry (GC-MS) combination with biomedical results to evaluate the effect of vitamin E treatment on methomyl poisoning rats. The rats were divided into three groups: the control group, methomyl poisoning group, and vitamin E treatment group. Partial least squares discriminate analysis (PLS-DA) showed that methomyl poisoning induced metabolic perturbations. Compared to the control group, based on the urinary metabolomics data, the level of ribitol, l-proline, xylitol, hydrocinnamic acid, 11-cis-octadecenoic acid, octadecanoic acid, and hexadecanoic acid of methomyl poisoning group increased, while the level of 2,3,4-trihydroxybutyric acid, ethanimidic acid, pantothenic acid, and retinoic acid decreased...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28325140/vitamins-in-heart-failure-friend-or-enemy
#9
George Georgiopoulos, Christina Chrysohoou, Georgia Vogiatzi, Nikolaos Magkas, Ippokratis Bournelis, Sofia Bampali, Damien Gruson, Dimitris Tousoulis
BACKGROUND: The failing heart is characterized by a depleted metabolic energy reserve and the up-regulation of several molecular mechanisms leading to cardiac hypertrophy, inflammation, fibrosis, angiogenesis, and apoptosis. Dietary or non-dietary supplementation of vitamins could potentially benefit energy balance. OBJECTIVE: The objective of the present study was to evaluate all available information on vitamins supplementation in patients with chronic HF for possible beneficial effect on metabolic, inotropic, chronotropic and hemodynamic indices...
March 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28303787/screening-natural-content-of-water-soluble-b-vitamins-in-fish-enzymatic-extraction-hilic-separation-and-tandem-mass-spectrometric-determination
#10
Niladri Sekhar Chatterjee, K Ashok Kumar, K K Ajeeshkumar, K R Remya Kumari, K V Vishnu, Rangasamy Anandan, Suseela Mathew, C N Ravishankar
Despite the potential of LC with tandem MS (MS/MS) in improving sensitivity and selectivity, analytical methods are scarce for the determination of protein-bound and phosphorylated forms of B vitamins in food. This prompted us to develop a method for LC-MS/MS determination of naturally occurring nicotinamide, nicotinic acid, thiamine, pyridoxine, riboflavin, pantothenic acid, biotin, folic acid, and cyanocobalamin in fish. Baseline separation of the vitamins was achieved in a hydrophilic interaction LC condition...
May 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28259021/gas-chromatography-mass-spectrometry-profiles-of-urinary-organic-acids-in-healthy-captive-cheetahs-acinonyx-jubatus
#11
Adrian Stephen Wolferstan Tordiffe, Mari van Reenen, Fred Reyers, Lodewyk Jacobus Mienie
In captivity, cheetahs (Acinonyx jubatus) frequently suffer from several unusual chronic diseases that rarely occur in their free-ranging counterparts. In order to develop a better understanding of their metabolism and health we documented the urine organic acids of 41 apparently healthy captive cheetahs, in an untargeted metabolomic study, using gas chromatography-mass spectrometry. A total of 339 organic acids were detected and annotated. Phenolic compounds, thought to be produced by the anaerobic fermentation of aromatic amino acids in the distal colon, as well as their corresponding glycine conjugates, were present in high concentrations...
April 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28239413/improving-acetyl-coa-biosynthesis-in-saccharomyces-cerevisiae-via-the-overexpression-of-pantothenate-kinase-and-pdh-bypass
#12
Wenshan Liu, Bo Zhang, Rongrong Jiang
BACKGROUND: Acetyl-CoA is an important precursor in Saccharomyces cerevisiae. Various approaches have been adopted to improve its cytosolic level previously with the emphasis on engineering the "acetyl-" part of acetyl-CoA. To the best of our knowledge, there have been no reports on engineering the "-CoA" part so far. RESULTS: In this study, we had tried to engineer S. cerevisiae from both the "-CoA" part via pantothenate kinase overexpression (PanK from S. cerevisiae, the rate-limiting enzyme for CoA synthesis) and the "acetyl-"part through PDH bypass introduction (ALD6 from S...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28182848/simultaneous-determination-of-8-b-vitamins-in-rat-intestinal-perfusate-to-identify-effects-of-osmotic-pressures-on-absorptions
#13
Xiaobo Wang, Jian Xiao, Hui Zhou, Ying Qiu, Hui Peng, Yangyang Sun, Jiwen Zhang, Wei Qian, Lixin Sun
A rapid and accurate HPLC-DAD method was developed and validated to simultaneously determine eight B-vitamins (VBs, namely thiamine, riboflavin, niacinamide, calcium pantothenic, pyridoxine, biotin, folic acid, and cyanocobalamin) and phenolsulfonphthalein in rat intestinal perfusate. Chromatography separation was achieved using an Inertsil ODS-3 column (250 × 4.6 mm i.d., 5 µm) at the temperature of 40 °C. Gradient elution mode was applied at the flow rate of 1.0 mL/min with the mobile phase of acetonitrile-30 mM K2 HPO4 (pH 5...
February 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28109598/identification-and-analysis-of-the-expression-of-microrna-from-lactating-and-nonlactating-mammary-glands-of-the-chinese-swamp-buffalo
#14
Xiaoyan Cai, Qingyou Liu, Xiaoxi Zhang, Yanping Ren, Xiaocan Lei, Sheng Li, Qiuping Chen, Kai Deng, Ping Wang, Haihang Zhang, Deshun Shi
To study the role of microRNA (miR) in the lactation physiology of water buffalo, 2 multiparous dairy buffaloes (including an 8-yr-old buffalo that had been lactating for 3 mo, as well as a 10-yr-old nonlactating, nonpregnant buffalo) were used for miR library construction. The profile of differentially expressed miR in lactating and nonlactating mammary gland tissues of these water buffalo were investigated using Illumina-Solexa high-throughput sequencing technology (Illumina, San Diego, CA). The data identified 259 miR families, 359 mature miR, 363 pre-miR, 230 novel buffalo miR, and 5 buffalo-specific miR that were expressed in mammary tissues...
March 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28064091/dose-response-characteristics-of-clematis-triterpenoid-saponins-and-clematichinenoside-ar-in-rheumatoid-arthritis-rats-by-liquid-chromatography-mass-spectrometry-based-serum-and-urine-metabolomics
#15
Rui Li, Lin-Xiu Guo, Yi Li, Wen-Qi Chang, Jian-Qun Liu, Li-Fang Liu, Gui-Zhong Xin
Clematidis Radix et Rhizoma is a traditional Chinese medicine widely used for treating arthritic disease. Clematis triterpenoid saponins (TS) and clematichinenoside AR (C-AR) have been considered to be responsible for its antiarthritic effects. However, the underling mechanism is still unclear because of their low bioavailability. To address of this issue, metabolomics tools were performed to determine metabolic variations associated with rheumatoid arthritis (RA) and responses to Clematis TS, C-AR and positive drug (Triptolide, TP) treatments...
March 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28043624/new-insights-into-the-mechanism-of-action-of-pyrazinamide-implications-for-susceptibility-testing-and-future-regimens
#16
Richard M Anthony, Alice den Hertog, Mikael Mansjö, Jim Werngren
Pyrazinamide (PZA) is included in the 2016 World Health Organization multidrug-resistant tuberculosis treatment guidelines and is a key component of most ongoing clinical trials investigating novel antibiotic combinations. PZA resistance is associated with worse tuberculosis treatment outcomes. Unfortunately, for such an important drug, phenotypic susceptibility testing is extremely challenging. The exacting bacterial growth conditions required to induce susceptibility to the drug reduce the accuracy of the susceptibility assay, even in experienced laboratories, and widespread testing is not performed...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28029544/lc-ms-ms-method-for-quantitation-of-seven-biomarkers-in-human-plasma-for-the-assessment-of-insulin-resistance-and-impaired-glucose-tolerance
#17
Qibo Zhang, Lisa A Ford, Kelli D Goodman, Tiffany A Freed, Deirdre M Hauser, Jessie K Conner, Kate E T Vroom, Douglas R Toal
Early detection of insulin resistance (IR) and/or impaired glucose tolerance (IGT) is crucial for delaying and preventing the progression toward type 2 diabetes. We recently developed and validated a straightforward metabolite-based test for the assessment of IR and IGT in a single LC-MS/MS method. Plasma samples were diluted with isotopically-labeled internal standards and extracted by simple protein precipitation. The extracts were analyzed by LC-MS/MS for the quantitation of 2-hydroxybutyric acid (0.500-40...
October 24, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27999767/antimicrobial-efficacy-of-the-combination-of-chlorhexidine-digluconate-and-dexpanthenol
#18
Axel Kramer, Ojan Assadian, Torsten Koburger-Janssen
Objective: The objective of this standardised experimental study was to investigate the antimicrobial efficacy of the combination of chlorhexidine digluconate (CHX) and the anti-inflammatory pro-vitamin dexpanthenol, which stimulates wound-healing, in the form of Bepanthen(®) Antiseptic Wound Cream, in order to rule out possible antagonistic combination effects of CHX and the alcohol analogue of pantothenic acid (vitamin B5) dexpanthenol. Method: Testing was carried out using the quantitative suspension test at conditions simulating wound bio-burden...
2016: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/27966211/detection-of-pantothenic-acid-immunoreactive-neurons-in-the-rat-lateral-septal-nucleus-by-a-newly-developed-antibody
#19
Arturo Mangas, Javier Yajeya, Noelia Gonzalez, Marianne Husson, Michel Geffard, Rafael Coveñas
INTRODUCTION: The available immunohistochemical techniques have documented restricted distribution of vitamins in the mammalian brain. The aim of the study was to develop a highly specific antiserum directed against pantothenic acid to explore the presence of this vitamin in the mammalian brain. MATERIAL AND METHODS: According to ELISA tests, the anti-pantothenic acid antiserum used showed a good affinity (10-8 M) and specificity. The antiserum was raised in rabbits...
2016: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/27933994/serum-metabolomics-analysis-of-quercetin-against-acrylamide-induced-toxicity-in-rats
#20
Shuang Yang, Can Cao, Shuai Chen, Liyan Hu, Wei Bao, Haidan Shi, Xiujuan Zhao, Changhao Sun
The current study aimed to investigate whether quercetin plays a protective role in acrylamide (AA)-induced toxicity using a metabolomics approach. Rats were randomly divided into groups as follows: control, treated with AA [5 mg/kg body weight (bw)], treated with different dosages of quercetin (10 and 50 mg/kg bw, respectively), and treated with two dosages of quercetin plus AA. After a 16 week treatment, rat serum was collected for metabolomics analysis. Biochemical tests and examination of liver histopathology were further conducted to verify metabolic alterations...
December 7, 2016: Journal of Agricultural and Food Chemistry
keyword
keyword
113721
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"