keyword
MENU ▼
Read by QxMD icon Read
search

pantothenic acid

keyword
https://www.readbyqxmd.com/read/28922393/a-set-of-nutrient-limitations-trigger-yeast-cell-death-in-a-nitrogen-dependent-manner-during-wine-alcoholic-fermentation
#1
Camille Duc, Martine Pradal, Isabelle Sanchez, Jessica Noble, Catherine Tesnière, Bruno Blondin
Yeast cell death can occur during wine alcoholic fermentation. It is generally considered to result from ethanol stress that impacts membrane integrity. This cell death mainly occurs when grape musts processing reduces lipid availability, resulting in weaker membrane resistance to ethanol. However the mechanisms underlying cell death in these conditions remain unclear. We examined cell death occurrence considering yeast cells ability to elicit an appropriate response to a given nutrient limitation and thus survive starvation...
2017: PloS One
https://www.readbyqxmd.com/read/28911222/a-ratiometric-fluorescent-probe-for-imaging-of-pantetheinase-in-living-cells
#2
Yiming Hu, Hongyu Li, Wen Shi, Huimin Ma
Pantetheinase, which catalyzes the cleavage of pantetheine to pantothenic acid (vitamin B5) and cysteamine, is involved in the regulation of oxidative stress, pantothenate recycling and cell migration. However, further elucidating the cellular function of this enzyme is largely limited by the lack of a suitable fluorescence imaging probe. By conjugating pantothenic acid with cresyl violet, herein we develop a new fluorescence probe CV-PA for the assay of pantetheinase. The probe not only possesses long analytical wavelengths but also displays linear ratiometric (I628/582 nm) fluorescence response to pantetheinase in the range of 5-400 ng/mL with a detection limit of 4...
September 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28857456/integration-of-transcriptomic-and-metabolomic-data-reveals-enhanced-steroid-hormone-biosynthesis-in-mouse-uterus-during-decidualization
#3
Ji-Long Liu, Wen-Qian Zhang, Miao Zhao, Ming-Yu Huang
It has been long recognized that decidualization is accompanied by significant changes in metabolic pathways. In the present study, we used the GC-TOF-MS approach to investigate the global metabolite profile changes associated with decidualization of mouse uterus on day 8 of pregnancy. We identified a total of 20 differentially accumulated metabolites, of which 9 metabolites were down-regulated and 11 metabolites were up-regulated. As expected, 7 differentially accumulated metabolites were involved in carbohydrate metabolism...
August 31, 2017: Proteomics
https://www.readbyqxmd.com/read/28780108/the-effect-of-bleaching-agents-on-the-degradation-of-vitamins-and-carotenoids-in-spray-dried-whey-protein-concentrate
#4
M A Stout, C W Park, M A Drake
Previous research has shown that bleaching affects flavor and functionality of whey proteins. The role of different bleaching agents on vitamin and carotenoid degradation is unknown. The objective of this study was to determine the effects of bleaching whey with traditional annatto (norbixin) by hydrogen peroxide (HP), benzoyl peroxide (BP), or native lactoperoxidase (LP) on vitamin and carotenoid degradation in spray-dried whey protein concentrate 80% protein (WPC80). An alternative colorant was also evaluated...
August 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28743678/the-saliva-exposome-for-monitoring-of-individuals-health-trajectories
#5
Vincent Bessonneau, Janusz Pawliszyn, Stephen M Rappaport
BACKGROUND: There is increasing evidence that environmental, rather than genetic, factors are the major causes of most chronic diseases. By measuring entire classes of chemicals in archived biospecimens, exposome-wide association studies (EWAS) are being conducted to investigate associations between a myriad of exposures received during life and chronic diseases. OBJECTIVES: Because the intraindividual variability in biomarker levels, arising from changes in environmental exposures from conception onwards, leads to attenuation of exposure-disease associations, we posit that saliva can be collected repeatedly in longitudinal studies to reduce exposure-measurement errors in EWAS...
July 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28739188/the-long-term-relationship-between-dietary-pantothenic-acid-vitamin-b5-intake-and-c-reactive-protein-concentration-in-adults-aged-40-years-and-older
#6
S Jung, M K Kim, B Y Choi
BACKGROUND AND AIMS: Low-grade inflammation, represented by minor C-reactive protein (CRP) elevation, has a critical role in the early stages of atherosclerosis, and pantothenic acid (PA) may have an antioxidant effect in inflammatory process. However, the long-term relationship between PA intake and CRP has not yet been studied. The objective of the present study was to evaluate the long-term relationship of PA intake to CRP concentration in healthy adults aged 40 years or older living in a rural area of South Korea...
September 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28676844/genetic-characterization-of-coenzyme-a-biosynthesis-reveals-essential-distinctive-functions-during-malaria-parasite-development-in-blood-and-mosquito
#7
Robert J Hart, Amanah Abraham, Ahmed S I Aly
Coenzyme A (CoA) is an essential universal cofactor for all prokaryotic and eukaryotic cells. In nearly all non-photosynthetic cells, CoA biosynthesis depends on the uptake and phosphorylation of vitamin B5 (pantothenic acid or pantothenate). Recently, putative pantothenate transporter (PAT) and pantothenate kinases (PanKs) were functionally characterized in P. yoelii. PAT and PanKs were shown to be dispensable for blood stage development, but they were essential for mosquito stages development. Yet, little is known about the cellular functions of the other enzymes of the CoA biosynthesis pathway in malaria parasite life cycle stages...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28656061/metabolomics-identifies-metabolic-markers-of-maturation-in-human-pluripotent-stem-cell-derived-cardiomyocytes
#8
Vijesh J Bhute, Xiaoping Bao, Kaitlin K Dunn, Kylie R Knutson, Eric C McCurry, Gyuhyung Jin, Wei-Hua Lee, Sarah Lewis, Akihiro Ikeda, Sean P Palecek
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despite these advances, hPSC-CMs exhibit an immature phenotype and are arrhythmogenic in vivo, necessitating development of strategies to mature these cells. hPSC-CMs undergo significant metabolic alterations during differentiation and maturation...
2017: Theranostics
https://www.readbyqxmd.com/read/28655181/pantothenate-auxotrophy-in-zymomonas-mobilis-zm4-is-due-to-a-lack-of-aspartate-decarboxylase-activity
#9
Jennifer R Gliessman, Timothy A Kremer, Amee A Sangani, Sara E Jones-Burrage, James B McKinlay
The bacterium Zymomonas mobilis naturally produces ethanol at near theoretical maximum yields, making it of interest for industrial ethanol production. Zymomonas mobilis requires the vitamin pantothenate for growth. Here we characterized the genetic basis for the Z. mobilis pantothenate auxotrophy. We found that this auxotrophy is due to the absence of a single gene, panD, encoding aspartate-decarboxylase. Heterologous expression of Escherichia coli PanD in Z. mobilis or supplementation of the growth medium with the product of PanD activity, β-alanine, eliminated the need for exogenous pantothenate...
July 6, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28641834/establishment-and-molecular-modeling-study-of-maltodextrin-based-synergistic-enantioseparation-systems-with-two-new-hydroxy-acid-chiral-ionic-liquids-as-additives-in-capillary-electrophoresis
#10
Xuan Yang, Yingxiang Du, Zijie Feng, Zongran Liu, Jingtang Li
Discovering more superior performance of ionic liquids for the separation science has triggered increasing interest. In this work, two new Hydroxy acid-based chiral ionic liquids (CILs) (tertramethylammonium-d-pantothenate (TMA-d-PAN), tertramethylammonium-d-quinate (TMA-d-QUI)) were designed and first used as additives to establish the maltodextrin-based synergistic systems for enantioseparation in capillary electrophoresis (CE). Compared to traditional single maltodextrin chiral separation system, significantly improved separations of all tested drugs in the CIL/Maltodextrin synergistic systems were obtained...
June 2, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28629539/uplc-esi-qtof-ms-based-metabolomics-survey-on-the-toxicity-of-triptolide-and-detoxication-of-licorice
#11
Zhuo Wang, Jian-Qun Liu, Jin-Di Xu, He Zhu, Ming Kong, Guo-Hua Zhang, Su-Min Duan, Xiu-Yang Li, Guang-Fu Li, Li-Fang Liu, Song-Lin Li
Triptolide (TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory, immunosuppressive, and anticancer activities. TP is specially used for the treatment of awkward rheumatoid arthritis, but its clinical application is confined by intense side effects. It is reported that licorice can obviously reduce the toxicity of TP, but the detailed mechanisms involved have not been comprehensively investigated. The current study aimed to explore metabolomics characteristics of the toxic reaction induced by TP and the intervention effect of licorice water extraction (LWE) against such toxicity...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28592011/-gas-chromatography-mass-spectrometry-based-urinary-metabolomics-in-very-low-birth-weight-premature-infants
#12
S T Li, X L Huang, S G Wu, Y M Ma, C C Shi, X Xiao, H Hao
Objective: To investigate the urinary metabolic spectrum and pathways in very low birth weight (VLBW) premature infants. Method: A prospective case-control study was conducted to collect and compare the data of VLBW premature infants and full term infants from the Sixth Affiliated Hospital of Sun Yet-Sen University in 2014. Within 24 hours after birth, urine specimens in each group were collected. Metabolites of urine samples including amino acid, fatty acid and organic acid were detected using the urease pre-processing and gas chromatography mass spectrometry (GC-MS) technology...
June 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28587349/gut-flora-profiling-and-fecal-metabolite-composition-of-colorectal-cancer-patients-and-healthy-individuals
#13
Xiaoxue Wang, Jianping Wang, Benqiang Rao, Li Deng
Colorectal cancer is one of the most common types of cancer in the world and its morbidity and mortality rates are increasing due to alterations to human lifestyle and dietary habits. The relationship between human gut flora and colorectal cancer has attracted increasing attention. In the present study, a metabolic fingerprinting technique that combined pyrosequencing with gas chromatography-mass spectrometry was utilized to compare the differences in gut flora profiling and fecal metabolites between healthy individuals and patients with colorectal cancer...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28576495/metabolic-pathway-catalyzed-by-vanin-1-pantetheinase-plays-a-suppressive-role-in-influenza-virus-replication-in-human-alveolar-epithelial-a549-cells
#14
Nobuko Yamashita, Masato Yashiro, Hirohito Ogawa, Hikaru Namba, Nobuyuki Nosaka, Yousuke Fujii, Tsuneo Morishima, Hirokazu Tsukahara, Masao Yamada
Our previous analysis of gene expression profiles in the peripheral blood from patients with influenza A (H1N1) pdm09 pneumonia revealed elevated transcription levels of the vanin-1 (vascular non-inflammatory molecule 1, VNN1) gene, which encodes an epithelial ectoenzyme with pantetheinase activity involved in recycling coenzyme A. Here, to elucidate the role of VNN1 in influenza A virus (IAV) H1N1 infection, we investigated the change of VNN1 expression in the context of IAV infection and the effects of its related substances, i...
August 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28572924/physicochemical-functional-and-nutritional-characteristics-of-stabilized-rice-bran-form-tarom-cultivar
#15
Ali Rafe, Alireza Sadeghian, Seyedeh Zohreh Hoseini-Yazdi
Extrusion is a multistep thermal process which has been utilized in a wide spectrum of food preparations. The effect of extrusion processing on the physicochemical, nutritional, and functional properties of Tarom cultivar rice bran was studied. However, the color of rice bran was improved by extrusion processing, but the protein content was reduced in the stabilized rice bran, which can be related to the denaturation of protein. Extrusion had also a reduction significant effect on the phytic acid as well as vitamin E in rice bran...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28539709/multipathway-integrated-adjustment-mechanism-of-glycyrrhiza-triterpenes-curing-gastric-ulcer-in-rats
#16
Ying Wang, Shuai Wang, Yongrui Bao, Tianjiao Li, Xin Chang, Guanlin Yang, Xiansheng Meng
BACKGROUND: Gastric ulcer is a common chronic disease in human digestive system, which is difficult to cure, easy to relapse, and endangers human health seriously. Compared with western medicine, traditional Chinese medicine has a unique advantage in improving the general situation, stablizing medical condition, and with little side effects. Glycyrrhiza known as "king of all the medicine", has a range of pharmacological activities and is commonly used in a variety of proprietary Chinese medicines and formulations...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28520815/metabolic-profiling-by-gas-chromatography-mass-spectrometry-of-energy-metabolism-in-high-fat-diet-fed-obese-mice
#17
Daxesh P Patel, Kristopher W Krausz, Cen Xie, Diren Beyoğlu, Frank J Gonzalez, Jeffrey R Idle
A novel, selective and sensitive single-ion monitoring (SIM) gas chromatography-mass spectrometry (GCMS) method was developed and validated for the determination of energy metabolites related to glycolysis, the tricarboxylic acid (TCA) cycle, glutaminolysis, and fatty acid β-oxidation. This assay used N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) containing 1% tert-butyldimethylchlorosilane (TBDMCS) as derivatizing reagent and was highly reproducible, sensitive, specific and robust. The assay was used to analyze liver tissue and serum from C57BL/6N obese mice fed a high-fat diet (HFD) and C57BL/6N mice fed normal chow for 8 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28505069/b-vitamin-intake-from-diet-and-supplements-and-breast-cancer-risk-in-middle-aged-women-results-from-the-prospective-nutrinet-sant%C3%A3-cohort
#18
Manon Egnell, Philippine Fassier, Lucie Lécuyer, Laurent Zelek, Marie-Paule Vasson, Serge Hercberg, Paule Latino-Martel, Pilar Galan, Mélanie Deschasaux, Mathilde Touvier
Experimental studies suggest a protective effect of B-vitamins on breast cancer risk, potentially modulated by alcohol intake. However, epidemiological studies are limited, especially regarding non-folate B-vitamins. Furthermore, few studies included quantitative assessment of supplemental intake. This prospective study aimed to investigate the associations between intakes of B-vitamins (dietary, supplemental, total) and breast cancer risk. 27,853 women aged ≥45 years from the NutriNet-Santé cohort (2009-2016) were included, with a median follow-up time of 4...
May 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28501405/short-communication-nutrient-consumption-patterns-of-lactobacillus-acidophilus-klds-1-0738-in-controlled-ph-batch-fermentations
#19
Xuepeng Lv, Gefei Liu, Xiaomei Sun, Hongyu Chen, Jiahui Sun, Zhen Feng
This work focused on elucidating the nutrient consumption patterns of Lactobacillus acidophilus to guide the design of media for high-cell-density culture. We investigated the nutrient consumption patterns of L. acidophilus KLDS 1.0738 in chemically defined media in controlled pH batch fermentations. The most abundantly consumed amino acids, vitamins, ions, and purines and pyrimidines were Glu and Gly, pyridoxine and nicotinamide, K(+) and PO4(3-), and guanine and uracil, respectively. The highest consumption rates for amino acids, vitamins, ions, and purines and pyrimidines were Asp and Arg, folic acid and pyridoxine, Fe(2+) and Mn(2+), and uracil and thymine, respectively...
July 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28490678/implications-of-us-nutrition-facts-label-changes-on-micronutrient-density-of-fortified-foods-and-supplements
#20
Michael I McBurney, Sonia Hartunian-Sowa, Nathan V Matusheski
The US FDA published new nutrition-labeling regulations in May 2016. For the first time since the implementation of the Nutrition Labeling and Education Act of 1990, the Daily Value (DV) for most vitamins will change, as will the units of measurement used in nutrition labeling for some vitamins. For some food categories, the Reference Amounts Customarily Consumed (RACCs) will increase to reflect portions commonly consumed on a single occasion. These regulatory changes are now effective, and product label changes will be mandatory beginning 26 July 2018...
June 2017: Journal of Nutrition
keyword
keyword
113721
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"