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pantothenic acid

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https://www.readbyqxmd.com/read/29775480/titan-cells-formation-in-cryptococcus-neoformans-is-finely-tuned-by-environmental-conditions-and-modulated-by-positive-and-negative-genetic-regulators
#1
Benjamin Hommel, Liliane Mukaremera, Radames J B Cordero, Carolina Coelho, Christopher A Desjardins, Aude Sturny-Leclère, Guilhem Janbon, John R Perfect, James A Fraser, Arturo Casadevall, Christina A Cuomo, Françoise Dromer, Kirsten Nielsen, Alexandre Alanio
The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> 10 μm and up to 100 μm). We found and optimized in vitro conditions that produce titan cells in order to identify the ancestry of titan cells, the environmental determinants, and the key gene regulators of titan cell formation. Titan cells generated in vitro harbor the main characteristics of titan cells produced in vivo including their large cell size (>10 μm), polyploidy with a single nucleus, large vacuole, dense capsule, and thick cell wall...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29751077/procyanidin-b2-protects-against-d-galactose-induced-mimetic-aging-in-mice-metabolites-and-microbiome-analysis
#2
Ying Xiao, Jialin Dong, Zhiting Yin, Qiguo Wu, Yiming Zhou, Xiaoli Zhou
To elucidate the possible mechanisms for the preventive effect of procyanidin B2 on aging, a combined analysis of metabolic profile and gut microbiome was carried out in the present study. The mimetic aged mice induced by d-galactose injection (500 mg/kg, sc daily), and the preventive group was fed with the diet plus 0.2% procyanidin B2. After 7 weeks of treatment, the spatial memory was assayed using the Morris water maze test. Procyanidin B2 significantly ameliorated the impaired memory and antioxidant abilities induced by d-galactose...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29737393/a-highly-active-pantothenate-synthetase-from-corynebacterium-glutamicum-enables-the-production-of-d-pantothenic-acid-with-high-productivity
#3
Fitsum Tigu, Junli Zhang, Guoxia Liu, Zhen Cai, Yin Li
D-Pantothenic acid (vitamin B5 ) has wide applications in the feed, food, chemical, and pharmaceutical industries. Its biological production routes which employ pantothenate synthetase (PS) as the key enzyme are attractive since they avoid the tedious and time-consuming optical resolution process. However, little data is available on the activity and kinetics of this enzyme, hampering the rational selection of an efficient enzyme for the biological production of D-pantothenic acid. In this study, six phylogenetically distant PS-encoding genes, from Escherichia coli, Corynebacterium glutamicum, Bacillus subtilis, Bacillus thuringiensis, Bacillus cereus, and Enterobacter cloacae, were expressed in E...
May 8, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29729635/an-integrative-investigation-of-the-therapeutic-mechanism-of-ainsliaea-fragrans-champ-in-cervicitis-using-liquid-chromatography-tandem-mass-spectrometry-based-on-a-rat-plasma-metabolomics-strategy
#4
Xiaoyong Zhang, Mingzhen He, Shuangxia Lei, Bei Wu, Ting Tan, Hui Ouyang, Wen Xu, Yulin Feng
Cervicitis is an extremely common gynecological disease and can be induced by diverse factors such as Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium infections. Long-term unhealed cervicitis may lead to a series of diseases including endometritis, salpingitis, pelvic inflammatory disease, and chorioamnionitis. However, the pathogenesis of cervicitis remains unknown. Ainsliaea fragrans Champ. (AFC) has been widely used in clinical treatment of cervicitis. In the present study, we performed an integrative investigation involving histopathology analysis and non-target plasma metabolomics analysis in a cervicitis rat model induced by phenol mucilage, using ultra-performance liquid chromatography coupled with a tandem quadrupole time-of-flight mass spectrometry approach...
April 27, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29682906/profiles-of-streptococcus-thermophilus-mn-zlw-002-nutrient-requirements-in-controlled-ph-batch-fermentations
#5
Gefei Liu, Yali Qiao, Yanjiao Zhang, Cong Leng, Jiahui Sun, Hongyu Chen, Yan Zhang, Aili Li, Zhen Feng
This study aimed to evaluate the profiles of Streptococcus thermophilus nutrient requirements to guide the design of media for high cell density culturing. The growth kinetics, physiological state, and nutrient requirement profiles of S. thermophilus were analyzed in chemically defined media. The results showed that the intracellular ATP concentration, H+ -ATPase activity, NADH/NAD+ , and NH3 concentrations varied with intracellular pH. The nutrient components with the highest amounts required were Leu and Asp; ascorbic acid and p-amino benzoic acid; K+ and PO4 3- ; and guanine and uracil...
April 22, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29669219/biotin-and-pantothenic-acid-over-supplementation-to-conditional-slc5a6-ko-mice-prevents-the-development-of-intestinal-mucosal-abnormalities-and-growth-defects
#6
Subrata Sabui, Rubina Kapadia, Abhisek Ghosal, Michael Schneider, Nils Lambrecht, Hamid M Said
Intestinal absorption of the water-soluble vitamins, biotin and pantothenic acid is carrier-mediated and involves the sodium-dependent multivitamin transporter (SMVT; product of the SLC5A6 gene). We recently observed that intestinal-specific (conditional) knockout of the mouse Slc5a6 gene (SMVT-cKO) is associated with growth retardation, the development of spontaneous and severe inflammation, abnormal histology in the large intestine, altered gut permeability, and early death. Our aim in this study was to examine the possibility that biotin and pantothenic acid over-supplementation (BPS) of the SMVT-cKO mice could reverse the above-described abnormalities...
April 18, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29658313/metabonomic-analysis-of-toxic-action-of-long-term-low-level-exposure-to-acrylamide-in-rat-serum
#7
C Cao, H Shi, M Zhang, L Bo, L Hu, S Li, S Chen, S Jia, Y J Liu, Y L Liu, X Zhao, L Zhang
This study assessed the effects of long-term, low-dose acrylamide (AA) administration in rats using ultra-performance liquid chromatography-mass spectrometry. Forty male Wistar rats were randomly divided into the following four groups: control, low-dose AA (0.2 mg/kg BW), middle-dose AA (1 mg/kg BW), and high-dose AA (5 mg/kg BW). AA was administered to rats via drinking water ad libitum. After 16-week treatment, rat serum was collected for metabonomic analysis. Biochemical tests were further conducted to verify metabolic alterations...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29656731/validity-of-an-ffq-to-measure-nutrient-and-food-intakes-in-tanzania
#8
Rachel M Zack, Kahema Irema, Patrick Kazonda, Germana H Leyna, Enju Liu, Susan Gilbert, Zohra Lukmanji, Donna Spiegelman, Wafaie Fawzi, Marina Njelekela, Japhet Killewo, Goodarz Danaei
OBJECTIVE: FFQ are often used to estimate food and nutrient intakes to rank individuals by their level of intake. We evaluated the relative validity of a semi-quantitative FFQ created for use in Tanzania by comparing it with two 24 h diet recalls. DESIGN: We measured relative validity of the FFQ with deattenuated energy-adjusted rank correlations for nutrients, deattenuated rank correlations for food groups, and performed a cross-classification analysis of energy-adjusted nutrient quartiles using percentage of agreement and Bland-Altman analysis...
April 16, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29626155/protein-coalation-and-antioxidant-function-of-coenzyme-a-in-prokaryotic-cells
#9
Yugo Tsuchiya, Alexander Zhyvoloup, Jovana Bakovic, Naam Thomas, Bess Yi Kun Yu, Sayoni Das, Christine Orengo, Clare Newell, John Ward, Giorgio Saladino, Federico Comitani, Francesco L Gervasio, Oksana M Malanchuk, Antonina I Khoruzhenko, Valeriy Filonenko, Sew Yeu Peak-Chew, Mark Skehel, Ivan Gout
In all living organisms, Coenzyme A (CoA) is an essential cofactor with a unique design allowing it to function as an acyl group carrier and a carbonyl-activating group in diverse biochemical reactions. It is synthesized in a highly conserved process in prokaryotes and eukaryotes that requires pantothenic acid (vitamin B5), cysteine and ATP. CoA and its thioester derivatives are involved in major metabolic pathways, allosteric interactions and the regulation of gene expression. A novel unconventional function of CoA in redox regulation has been recently discovered in mammalian cells and termed protein CoAlation...
April 6, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29624868/design-synthesis-and-in-vitro-anti-tubercular-activity-of-1-2-3-triazolyl-dihydroquinoline-derivatives
#10
Saleha Banu, Rajitha Bollu, Lingaiah Nagarapu, Jagadeesh Babu Nanubolu, Yogeswari Perumal, Dharmarajan Sriram, Shravan Kumar Gunda, Divyasphoorthi Vardhan
In the quest for new active molecules against Mycobacterium tuberculosis, a series of dihydroquinoline derivatives possessing triazolo substituents were efficiently synthesized using click chemistry. The structure of 6l was evidenced by X-ray crystallographic study. The newly synthesized compounds were evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC27294). The compounds 6a, 6g and 6j (MIC: 3.13 μg/mL) showed promising activity when compared to the first line drug such as ethambutol...
April 6, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29618338/optimal-dietary-patterns-designed-from-local-foods-to-achieve-maternal-nutritional-goals
#11
Jofrey Raymond, Neema Kassim, Jerman W Rose, Morris Agaba
BACKGROUND: Achieving nutritional requirements for pregnant and lactating mothers in rural households while maintaining the intake of local and culture-specific foods can be a difficult task. Deploying a linear goal programming approach can effectively generate optimal dietary patterns that incorporate local and culturally acceptable diets. The primary objective of this study was to determine whether a realistic and affordable diet that achieves nutritional goals for rural pregnant and lactating women can be formulated from locally available foods in Tanzania...
April 4, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29562658/association-between-dietary-intake-and-coronary-artery-calcification-in-non-dialysis-chronic-kidney-disease-the-progredir-study
#12
Alisson Diego Machado, Luz Marina Gómez, Dirce Maria Lobo Marchioni, Fernanda Silva Nogueira Dos Anjos, Maria Del Carmen Bisi Molina, Paulo Andrade Lotufo, Isabela Judith Martins Benseñor, Silvia Maria de Oliveira Titan
Coronary artery calcification (CAC) is a widespread condition in chronic kidney disease (CKD). Diet may play an important role in CAC, but this role is not clear. This study evaluated the association between macro-and micronutrient intakes and CAC in non-dialysis CKD patients. We analyzed the baseline data from 454 participants of the PROGREDIR study. Dietary intake was evaluated by a food frequency questionnaire. CAC was measured by computed tomography. After exclusion of participants with a coronary stent, 373 people remained for the analyses...
March 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29528727/suboptimal-vitamin-b-intakes-of-zambian-preschool-children-evaluation-of-24-hour-dietary-recalls
#13
Tyler J Titcomb, Samantha T Schmaelzle, Emily T Nuss, Jesse F Gregory, Sherry A Tanumihardjo
BACKGROUND: Hidden hunger affects individuals who chronically consume an inadequate intake of at least 1 micronutrient and is associated with low dietary diversity. Little data are available on dietary intake or status assessment of B vitamins among preschool children in Zambia. OBJECTIVES: The aim of this study was to assess 24-hour dietary recall records obtained from Zambian children aged 3 to 7 years for B vitamin intake in relation to adequacy and change over time in the same community...
January 1, 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29522513/fosmetpantotenate-re-024-a-phosphopantothenate-replacement-therapy-for-pantothenate-kinase-associated-neurodegeneration-mechanism-of-action-and-efficacy-in-nonclinical-models
#14
Daniel Elbaum, Maria G Beconi, Edith Monteagudo, Annalise Di Marco, Maria S Quinton, Kathryn A Lyons, Andrew Vaino, Steven Harper
In cells, phosphorylation of pantothenic acid to generate phosphopantothenic acid by the pantothenate kinase enzymes is the first step in coenzyme A synthesis. Pantothenate kinase 2, the isoform localized in neuronal cell mitochondria, is dysfunctional in patients with pantothenate kinase-associated neurodegeneration. Fosmetpantotenate is a phosphopantothenic acid prodrug in clinical development for treatment of pantothenate kinase-associated neurodegeneration, which aims to replenish phosphopantothenic acid in patients...
2018: PloS One
https://www.readbyqxmd.com/read/29503058/do-patterns-of-nutrient-intake-predict-self-reported-anxiety-depression-and-psychological-distress-in-adults-sepahan-study
#15
Amin Salehi-Abargouei, Ahmad Esmaillzadeh, Leila Azadbakht, Ammar Hassanzadeh Keshteli, Hamid Afshar, Awat Feizi, Christine Feinle-Bisset, Peyman Adibi
BACKGROUND & AIMS: Despite the growing evidence about dietary patterns, this study aimed at the association between patterns of nutrients intake and psychological disorders. METHODS: In this cross-sectional study, diet and psychological factors including anxiety, depression, and general health (GHQ) were assessed through self-administered questionnaires in 3846 Iranian adults. Daily intakes of 57 nutrients and bioactive compounds were calculated. Nutrient patterns (NPs) were derived using factor analysis...
February 21, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29463319/performance-of-arma-chinensis-reared-on-an-artificial-diet-formulated-using-transcriptomic-methods
#16
D Y Zou, T A Coudron, L S Zhang, X S Gu, W H Xu, X L Liu, H H Wu
An artificial diet formulated for continuous rearing of the predator Arma chinensis was inferior to natural prey when evaluated using life history parameters. A transcriptome analysis identified differentially expressed genes in diet-fed and prey-fed A. chinensis that were suggestive of molecular mechanisms underlying the nutritive impact of the artificial diet. Changes in the diet formulation were made based on the transcriptome analysis and tested using life history parameters. The quantity of pig liver, chicken egg, tuna fish, biotin, nicotinamide, vitamin B6, thiamine, riboflavin, vitamin C, L-glutamine, and sucrose was reduced, and wheat germ oil, calcium pantothenate and folic acid were increased...
February 21, 2018: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/29438868/investigation-of-the-reverse-effect-of-danhong-injection-on-doxorubicin-induced-cardiotoxicity-in-h9c2-cells-insight-by-lc-ms-based-non-targeted-metabolomic-analysis
#17
Xiaojiao Yi, Junfeng Zhu, Jinghui Zhang, Yun Gao, Zhongjian Chen, Shihai Lu, Zongwei Cai, Yanjun Hong, Yongjiang Wu
Although Danhong injection (DHI) has been clearly shown to attenuate ischemic myocardial injury and improve heart function, there is no research regarding its role in doxorubicin (DOX)-induced cardiomyopathy. In this study, we aimed to investigate the reverse effect of DHI on DOX-induced cardiotoxicity in H9c2 cells. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay demonstrated that DHI had no cytotoxicity towards the relevant cell line unless the concentration was as high as 50 μL/mL...
April 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29407636/comparative-proteomic-profiling-of-human-dental-pulp-stem-cells-and-periodontal-ligament-stem-cells-under-in-vitro-osteogenic-induction
#18
He Wang, Dandan Ma, Xiaoyi Zhang, Shuaimei Xu, Tingting Ning, Buling Wu
OBJECTIVE: This study aimed to compare the proteomic profiling of human dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) under in vitro osteogenic induction, which imitates the microenvironment during osteo-/odontogenesis of DPSCs and PDLSCs. DESIGN: The proteomic profiles of osteoinduced DPSCs and PDLSCs from a single donor were compared using the isobaric tag for relative and absolute quantitation (iTRAQ) technique and subsequent bioinformatics analysis...
May 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29387383/nutritional-physicochemical-and-functional-properties-of-protein-concentrate-and-isolate-of-newly-developed-bambara-groundnut-vigna-subterrenea-l-cultivars
#19
Olaposi R Adeleke, Oladipupo Q Adiamo, Olumide S Fawale
Bambara groundnut is an indigenous African vegetable grown mainly for human food and animal feed due to its high protein content. Different factors like varieties and origin can influence the chemical composition of Bambara groundnut cultivars. Therefore, the aims of this study are to produce defatted flour and protein concentrate from newly developed Bambara groundnut cultivars [Accessions No: TVSU 5 - Bambara Groundnut White (BGW) and TVSU 146 - Bambara Groundnut Brown (BGB)] and compare their nutritional, physicochemical, and functional properties with market sample [Bambara groundnut commercial (BGC)]...
January 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/29382740/a-plastidial-pantoate-transporter-with-a-potential-role-in-pantothenate-synthesis
#20
Lili Huang, Michal Pyc, Saleh Alseekh, Donald R McCarty, Valérie de Crécy-Lagard, Jesse F Gregory, Christopher S Henry, Alisdair R Fernie, Robert T Mullen, Andrew D Hanson
The pantothenate (vitamin B5 ) synthesis pathway in plants is not fully defined because the subcellular site of its ketopantoate → pantoate reduction step is unclear. However, the pathway is known to be split between cytosol, mitochondria, and potentially plastids, and inferred to involve mitochondrial or plastidial transport of ketopantoate or pantoate. No proteins that mediate these transport steps have been identified. Comparative genomic and transcriptomic analyses identified Arabidopsis thaliana BASS1 (At1g78560) and its maize ( Zea mays ) ortholog as candidates for such a transport role...
February 28, 2018: Biochemical Journal
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