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Meibomian gland disease

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https://www.readbyqxmd.com/read/29452004/review-of-literature-on-measurements-of-non-invasive-break-up-times-lipid-morphology-and-tear-meniscal-height-using-commercially-available-hand-held-instruments
#1
Louis Tong, Lim Shee Teng
Purpose/aims: Dry eye is a common multi-factorial disease characterized by tearfilm dysfunction. Diagnosis of dry eye requires documentation of tear status with non-invasive tear break up times (NIBUT), tear meniscal height (TMH), and tearfilm lipid layer. These parameters objectively assess tear stability and indirectly, the functional impact of meibomian gland dysfunction. While it is obvious that portable instrumentation gives broader access than fixed instrumentation, its value would be limited if it is unreliable and its precision and accuracy substantially worse than fixed instruments...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29438123/relationships-between-meibomian-gland-loss-and-age-sex-and-dry-eye
#2
Heiko Pult
PURPOSE: This study evaluated relationships between meibomian gland loss (MGL) and age, sex, and dry eye. METHODS: Dry eye and MGL of the lower eyelid was evaluated from 112 randomly selected subjects (66 women; mean age 62.8; SD ±15.7; and age range: 19-89 years) from Horst Riede GmbH, Weinheim, Germany. In addition, subjects were grouped into dry eye and non-dry eye by the Ocular Surface Disease Index (OSDI) score, lid-parallel conjunctival folds and non-invasive break-up time...
February 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29429299/-research-progress-of-intense-pulsed-light-treatment-on-meibomian-gland-dysfunction-and-relevant-dry-eye-diseases
#3
W J Song, X M Yan
Intense pulsed light (IPL) is a broad spectrum incoherent light which is produced by high-output xenon lamp. Since the invention of the first-generation IPL in 1994, IPL technology has been developing rapidly and extensively utilized in multiple fields relevant to dermatology across the world. In 2004, the fourth-generation IPL system was introduced with the optimal pulse technology (OPT) and has soon been used for cosmetic purposes all over the world. In 2002, Dr. Toyos found that the meibomian gland dysfunction (MGD) and dye eye disease (DED)symptoms of the rosacea patients who received IPL treatment have been improving significantly, therefore he started to explore the application of IPL system to treatment of dry eye disease...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29401594/very-long-chain-tear-film-lipids-produced-by-fatty-acid-elongase-elovl1-prevent-dry-eye-disease-in-mice
#4
Takayuki Sassa, Masato Tadaki, Hiroshi Kiyonari, Akio Kihara
Lipids secreted from the meibomian gland (meibum) form the superficial layer of the tear film and prevent water evaporation from the ocular surface and infection. Here, we identified the fatty acid (FA) elongases responsible for the synthesis of very long-chain FAs (VLCFAs) that constitute the meibum lipids. Elongation of VLCFAs (ELOVL)1 is primarily responsible for the production of saturated VLCFAs, whereas ELOVL1, ELOVL3, and ELOVL4 redundantly participate in the synthesis of monounsaturated VLCFAs. Gene disruption of Elovl1 in mice shortened acyl moieties in the 2 major meibum lipids: cholesteryl esters and wax esters...
January 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29401160/meibomian-gland-features-and-conjunctival-goblet-cell-density-in-glaucomatous-patients-controlled-with-prostaglandin-timolol-fixed-combinations-a-case-control-cross-sectional-study
#5
Luca Agnifili, Rodolfo Mastropasqua, Vincenzo Fasanella, Lorenza Brescia, Barbara Scatena, Francesco Oddone, Leonardo Mastropasqua
PURPOSE: To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs). METHODS: In this cross-sectional study, sixty Caucasian patients treated with PTFCs, fifteen with latanoprost+timolol (L+T) unfixed combination, and fifteen controls were enrolled. Patients underwent the Ocular Surface Disease Index (OSDI) questionnaire, tear film break-up time (BUT), corneal staining, Schirmer test I (STI), and IVCM of MGs and goblet cells (GCs)...
February 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29392636/dry-eye-and-meibomian-gland-dysfunction-in-pseudophakic-bullous-keratopathy
#6
Melis Palamar, Pelin Kiyat, Ayse Yagci
PURPOSE: To evaluate dry eye tests and meibography of patients with pseudophakic bullous keratopathy (PBK). MATERIALS AND METHODS: Thirty-seven patients with PBK were included. The eyes with PBK were compared with the normal pseudophakic fellow eyes. All patients had undergone a detailed ophthalmic examination including corneal and conjunctival fluorescein staining and Oxford scoring, tear film breakup time, Schirmer 1 test, Ocular Surface Disease Index (OSDI) score assessment, lid margin abnormalities, upper and lower eyelid Meibomian gland evaluation using infrared captures of a biomicroscope...
February 1, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29385185/association-between-meibomian-gland-dysfunction-and-compliance-of-topical-prostaglandin-analogs-in-patients-with-normal-tension-glaucoma
#7
Tae Hee Lee, Mi Sun Sung, Hwan Heo, Sang Woo Park
PURPOSE: The aim of this study was to investigate the association between tear film and meibomian gland parameters in patients with normal tension glaucoma (NTG), who underwent topical prostaglandin analog (PGA) monotherapy, and medication compliance. METHODS: Ocular surface disease index (OSDI), Schirmer's test, tear film break-up time (TBUT), keratoepitheliopathy (KEP) score with fluorescein, and meibomian gland parameters were assessed in 45 eyes of 45 patients with NTG (NTG group), who received topical PGA monotherapy for more than 1 year...
2018: PloS One
https://www.readbyqxmd.com/read/29377842/effects-of-lipid-versus-sodium-hyaluronate-containing-eye-drops-on-optical-quality-and-ocular-surface-parameters-as-a-function-of-the-meibomian-gland-dropout-rate
#8
Kata Miháltz, Eva Maria Faschinger, Pia Veronika Vécsei-Marlovits
PURPOSE: To evaluate the effect of lipid- versus sodium hyaluronate-based eye drops on optical quality and ocular surface parameters. METHODS: Sixty eyes of 30 patients with mild-to-moderate dry eye disease were included in a prospective randomized study. Each patient received either lipid- or sodium hyaluronate-based eye drops. Ocular symptom scores, breakup time, Schirmer test, fluorescein staining, noncontact meibography, and aberrometry were evaluated before and after 3 months of therapy...
January 25, 2018: Cornea
https://www.readbyqxmd.com/read/29337006/relation-between-dietary-essential-fatty-acid-intake-and-dry-eye-disease-and-meibomian-gland-dysfunction-in-postmenopausal-women
#9
Jillian F Ziemanski, Lynn R Wolters, Lisa Jones-Jordan, Jason J Nichols, Kelly K Nichols
PURPOSE: To evaluate the relationship between omega-3 (n-3) and omega-6 (n-6) fatty acids with dry eye disease (DED) and meibomian gland dysfunction (MGD) DESIGN: Cross-sectional study METHODS: Postmenopausal women (n=439) underwent a clinical evaluation and completed the Vio Food Frequency Questionnaire to estimate their dietary intake of n-3s and n-6s. Subjects were categorized into two binary classifications based upon whether or not they had (1) DED and (2) MGD. Mean intake of dietary fatty acids were compared with two-sample t-tests...
January 11, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29300267/ocular-surface-workup-with-automated-noninvasive-measurements-for-the-diagnosis-of-meibomian-gland-dysfunction
#10
Giuseppe Giannaccare, Luca Vigo, Marco Pellegrini, Stefano Sebastiani, Francesco Carones
PURPOSE: To analyze diagnostic performance of an ocular surface workup based on automated noninvasive measurements in the diagnosis of meibomian gland dysfunction (MGD). METHODS: Two hundred ninety-eight eyes of 149 patients with MGD and 54 eyes of 27 control patients were analyzed. Ocular Surface Disease Index (OSDI), noninvasive breakup time (BUT), lipid layer thickness, meibomian gland loss, and tear osmolarity were calculated. The correlations among variables in the MGD group were analyzed...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29286952/prevalence-of-meibomian-gland-atrophy-in-a-pediatric-population
#11
Preeya K Gupta, Madelyn N Stevens, Namita Kashyap, Yos Priestley
PURPOSE: To report the prevalence of meibomian gland atrophy and gland tortuosity in a pediatric population. METHODS: Participants who presented with no history of dry eye disease or meibomian gland dysfunction were recruited from the Duke University Eye Center. Meibography was performed and subjective symptoms were assessed through the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire. Grading of images was assessed by a masked rater using a previously validated 5-point meiboscale (0-4) for gland atrophy and a 3-point scale for gland tortuosity (0-2)...
December 1, 2017: Cornea
https://www.readbyqxmd.com/read/29282195/chloracne-in-a-farming-family
#12
Pragya Kushwaha, Harish Kumar, Sandeep Kulkarni, Ashok Ghorpade
An 11-year-old boy presented with a 1-year history of multiple comedonal lesions distributed over his body. The lesions (Figure 1) were densely distributed throughout his body. Ophthalmologic examination revealed hyperpigmented conjunctival mucosae and enlarged meibomian glands (Figure 2). His nails were also hyperpigmented. In addition, he had been coughing and had a fever, each present for a month. Significant laboratory studies included mild anemia (hemoglobin 11.6 gm%) and leukocytosis of 20,800. A chest x-ray was suggestive of interstitial lung disease...
2017: Skinmed
https://www.readbyqxmd.com/read/29240600/meibomian-gland-performance-in-glaucomatous-patients-with-long-term-instillation-of-iop-lowering-medications
#13
Wan-Hua Cho, Ing-Chou Lai, Po-Chiung Fang, Chun-Chih Chien, Shin-Ling Tseng, Yu-Hsuan Lai, Yu-Ting Huang, Ming-Tse Kuo
PURPOSE: To investigate the meibomian gland (MG) performance in patients with glaucoma under topical intraocular pressure (IOP)-lowering medications. METHODS: This was a cross-sectional case-control study. Patients with glaucoma under different dosages and instillation periods of topical IOP-lowering medications were included. A total of 30 eyes out of 30 healthy participants and 85 eyes out of 85 patients with glaucoma were analyzed. The burden of instilling anti-glaucoma agents (BAG) was simply scored for each participant based on the number, formula, frequency, and duration of topical IOP-lowering medications used...
December 13, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29234088/tear-proteome-analysis-in-ocular-surface-diseases-using-label-free-lc-ms-ms-and-multiplexed-microarray-biomarker-validation
#14
Javier Soria, Arantxa Acera, Jesús Merayo-LLoves, Juan A Durán, Nerea González, Sandra Rodriguez, Nikitas Bistolas, Soeren Schumacher, Frank F Bier, Harald Peter, Walter Stöcklein, Tatiana Suárez
We analyzed the tear film proteome of patients with dry eye (DE), meibomian gland dysfunction (MGD), and normal volunteers (CT). Tear samples were collected from 70 individuals. Of these, 37 samples were analyzed using spectral-counting-based LC-MS/MS label-free quantitation, and 33 samples were evaluated in the validation of candidate biomarkers employing customized antibody microarray assays. Comparative analysis of tear protein profiles revealed differences in the expression levels of 26 proteins, including protein S100A6, annexin A1, cystatin-S, thioredoxin, phospholipase A2, antileukoproteinase, and lactoperoxidase...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232760/the-association-of-keratoconus-with-blepharitis
#15
Dina Mostovoy, Shlomo Vinker, Michael Mimouni, Yakov Goldich, Shmuel Levartovsky, Igor Kaiserman
BACKGROUND: Identifying potentially treatable risk factors for the progression of keratoconus is of great importance. The purpose of this study was to determine the association between blepharitis and keratoconus. METHODS: In this prospective, comparative, observational study, 50 keratoconus participants from the central district of the Clalit Health Services Health Maintenance Organization in Israel underwent comprehensive eye examination. Seventy-two healthy medical personnel of similar ages were randomly chosen as a control group...
December 12, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29199865/changes-in-the-meibomian-gland-after-exposure-to-intense-pulsed-light-in-meibomian-gland-dysfunction-mgd-patients
#16
Yue Yin, Ninghua Liu, Lan Gong, Nan Song
PURPOSE: To observe (1) changes in meibomian gland (MG) after exposure to intense pulsed light (IPL) and (2) to understand the mechanism by which IPL treats meibomian gland dysfunction (MGD) in patients. METHODS: A cohort study, including 35 MGD patients, was conducted. IPL treatment was administered in one group (IPL group; n = 18), and eyelid hygiene in another (control group; n = 17) for 3 months. All patients were given artificial tears during the treatment period...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29183042/expression-and-regulation-of-s100-fused-type-protein-hornerin-at-the-ocular-surface-and-lacrimal-apparatus
#17
Fabian Garreis, Janine Jahn, Katharina Wild, Daniel B Abrar, Martin Schicht, Jens-Michael Schröder, Friedrich Paulsen
Purpose: The S100 fused-type proteins hornerin (HRNR) and filaggrin-2 (FLG2) are members of the epidermal differentiation complex, which is involved in terminal differentiation of keratinocytes via cornification as well as maintenance of the epidermal antimicrobial barrier. We investigated the expression and possible regulation of HRNR and FLG2 at the ocular surface and in the lacrimal apparatus. Methods: Tissues of the lacrimal apparatus and ocular surface were analyzed systematically by means of RT-PCR, immunohistochemistry, and immuntransmission electron microscopy (iTEM) for their ability to express and produce HRNR and FLG2...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29169367/image-based-quantitative-analysis-of-tear-film-lipid-layer-thickness-for-meibomian-gland-evaluation
#18
Hyeonha Hwang, Hee-Jae Jeon, Kin Choong Yow, Ho Sik Hwang, EuiHeon Chung
BACKGROUND: Dry eye syndrome is one of the most common ocular diseases, and meibomian gland dysfunction (MGD) is the leading cause of evaporative dry eye syndrome. When the tear film lipid layer becomes thin due to obstructive or hyposecretory meibomian gland dysfunction, the excessive evaporation of the aqueous layer can occur, and this causes evaporative dry eye syndrome. Thus, measuring the lipid layer thickness (LLT) is essential for accurate diagnosis and proper treatment of evaporative dry eye syndrome...
November 23, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29150990/prevalence-of-dry-eye-disease-and-its-association-with-dyslipidemia
#19
Krishnamoorthy Rathnakumar, Kaliaperumal Ramachandran, Durairaj Baba, Venkatachalam Ramesh, Velusamy Anebaracy, Ramachandran Vidhya, Rajamanickam Vinothkumar, Ramamurthy Poovitha, Rajagopalan Geetha
BACKGROUND: Dry eye disease (DED) is a common ocular surface disease significantly affecting the quality of life of patients. The aim of our study is to focus on the prevalence of DED and to determine the relationship between dyslipidemia and DED. METHODS: The study was performed with the age group of 25-70 years, who attended the ophthalmology outpatient department at Sri Lakshmi Narayana Institute of Medical Sciences with complaints of dry eye. A standard questionnaire was taken, and tear film tests were performed to diagnose dry eye...
November 18, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29140823/single-center-retrospective-study-on-meibomian-gland-loss-in-patients-with-ocular-chronic-graft-versus-host-disease
#20
Lijuan Que, Xiaofeng Zhang, Mengmeng Li
OBJECTIVES: This study aimed to analyze the influencing factors of meibomian gland loss in patients with ocular chronic graft-versus-host disease (GVHD) and its correlation with other clinical ocular surface assessment indexes. METHODS: The clinical data of patients with ocular chronic GVHD from the ocular surface and corneal outpatient clinic of the First Affiliated Hospital of Soochow University were reviewed from June 2012 to June 2016. The relationship between the percentage of meibomian gland acinar area and the influencing factors, such as patient's sex, age, transplantation method, human leukocyte antigen (HLA) matching, the time when eye discomfort appeared after transplantation (month), and the severity of ocular chronic GVHD, was investigated...
November 14, 2017: Eye & Contact Lens
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