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Meibomian gland disease

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https://www.readbyqxmd.com/read/29883739/impact-of-blinking-on-ocular-surface-and-tear-film-parameters
#1
Michael T M Wang, Leslie Tien, Alicia Han, Jung Min Lee, Dabin Kim, Maria Markoulli, Jennifer P Craig
PURPOSE: To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology. METHODS: A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session. RESULTS: Overall, a higher proportion of participants exhibiting incomplete blinking fulfilled the TFOS DEWS II dry eye diagnostic criteria (64% versus 44%, p = 0...
June 5, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29870437/anatomic-considerations-in-thyroid-eye-disease
#2
Jonathan J Dutton
PURPOSE: To review and summarize the clinical findings in thyroid eye disease (TED) related to the unique anatomical structures of the eyelids and orbit. METHODS: A PubMed search was performed searching for anatomical relationships between eyelid and orbital anatomy and the clinical findings of TED. RESULTS: The major clinical findings associated with TED are varied. They typically involve both the eyelid and the orbit. In the eyelid, usual findings include upper eyelid retraction, contour abnormalities, eyelid edema, prolapsed orbital fat, conjunctival injection and chemosis, caruncular edema, and meibomian gland dysfunction...
May 10, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29847195/evaluating-the-novel-application-of-cyclosporine-0-1-in-ocular-surface-disease
#3
Konstadinos G Boboridis, Anastasios G P Konstas
Ocular surface disease (OSD) is a highly prevalent symptomatic condition caused by dry eye disease (DED), intrinsic, environmental, or iatrogenic causes. It affects patient's visual function and quality of life. Its pathophysiology is centered on tear hyperosmolarity, inflammation, and epithelial damage. Current management is suboptimal and includes artificial tear supplementation and short-term use of topical steroids in severe cases. The recent approval of cyclosporine 0.1% has transformed management strategies of severe DED and moderate-to-severe OSD...
May 30, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29805249/efficacy-of-intra-meibomian-gland-injection-of-the-anti-vegf-agent-bevacizumab-for-the-treatment-of-meibomian-gland-dysfunction-with-lid-margin-vascularity
#4
Xiaodan Jiang, Yuexin Wang, Huibin Lv, Yan Liu, Mingzhou Zhang, Xuemin Li
Purpose: To investigate the efficacy of a novel treatment - intra-meibomian gland (MG) injection of the anti-VEGF agent bevacizumab - for MG dysfunction (MGD) with eyelid-margin vascularity. Methods: A total of 26 eyes from 13 patients diagnosed with MGD and eyelid-margin vascularity were included in our study. Patients received intra-meibomian gland injections of bevacizumab (150 μL, 2.5 mg/0.1 mL) at multiple sites with a 29 G needle where telangiectasia was severe...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29801153/the-level-of-inflammatory-tear-cytokines-is-elevated-in-congenital-aniridia-and-associated-with-meibomian-gland-dysfunction
#5
Erlend C S Landsend, Øygunn A Utheim, Hilde R Pedersen, Hans Christian D Aass, Neil Lagali, Darlene A Dartt, Rigmor C Baraas, Tor P Utheim
Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate cytokine levels with ophthalmologic findings. Methods: We examined 35 patients with aniridia and 21 healthy controls. Tear fluid was collected with Schirmer I test and capillary tubes from each eye, and the concentration of 27 inflammatory cytokines determined using multiplex bead assay. Eyes of all participants were examined with tests for dry eye disease, including evaluation of meibomian glands (meibography)...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29789014/a-review-of-scoring-systems-for-ocular-involvement-in-chronic-cutaneous-bullous-diseases
#6
REVIEW
Brendon W H Lee, Jeremy C K Tan, Melissa Radjenovic, Minas T Coroneo, Dedee F Murrell
BACKGROUND: Epidermolysis bullosa (EB) and autoimmune blistering diseases (AIBD) describe a group of rare chronic dermatoses characterized by cutaneous fragility and blistering. Although uncommon, significant ocular surface disease (OSD) may occur in both and require ophthalmological assessment. Disease scoring systems have a critical role in providing objective and accurate assessment of disease severity. The objectives of this report were, firstly, to document the prevalence and severity of ocular involvement in EB/AIBD...
May 22, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29757849/ocular-surface-findings-in-patients-with-lichen-planopilaris
#7
Mehdi Gheisari, Sahar Dadkhahfar, Kaveh Fadakar, Reza Mahmoud Robati, Hamideh Moravvej, Mohammad Soleimani, Reza Mirshahi
PURPOSE: Lichen planopilaris (LPP) is a chronic lymphocytic- mediated disorder that selectively involves hair follicles, leading to cicatricial alopecia. The eyelash follicle and meibomian gland (MG) might also be involved in the disease process leading to ocular surface problems. METHODS: In this Cross-sectional case -control study, twenty-three patients with histologically confirmed LPP and 23 healthy controls were recruited in this controlled study. To quantify the signs and symptoms of LPP, we used the Lichen Planopilaris Activity Index...
May 10, 2018: Cornea
https://www.readbyqxmd.com/read/29708939/outcomes-of-thermal-pulsation-treatment-for-dry-eye-syndrome-in-patients-with-sjogren-disease
#8
Morgan R Godin, Sandra S Stinnett, Preeya K Gupta
PURPOSE: To evaluate the clinical outcomes of thermal pulsation treatment in patients with meibomian gland dysfunction (MGD) and dry eye secondary to Sjogren disease. METHODS: Twenty-four eyes from 13 patients with previously diagnosed Sjogren disease who presented to our institution with dry eye symptoms and had thermal pulsation treatment were prospectively followed up. Patients underwent comprehensive slit-lamp examination, including MGD grading, gland oil flow, corneal and conjunctival staining scores, and tear break-up time (TBUT)...
April 26, 2018: Cornea
https://www.readbyqxmd.com/read/29692600/a-novel-system-tearcare-%C3%A2-for-the-treatment-of-the-signs-and-symptoms-of-dry-eye-disease
#9
David Badawi
Purpose: The objective of this study was to evaluate the safety and effectiveness of the TearCare® System in adult patients with clinically significant dry eye disease (DED). Patients and methods: This was a prospective, single-center, randomized, parallel-group, clinical trial. Subjects with DED were randomized to either a single TearCare treatment conducted at the clinic or 4 weeks of daily warm compress (WC) therapy. The TearCare procedure consisted of 12 minutes of thermal eyelid treatment immediately followed by manual expression of the meibomian glands...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29675376/clinical-efficacy-of-combined-topical-0-05-cyclosporine-a-and-0-1-sodium-hyaluronate-in-the-dry-eyes-with-meibomian-gland-dysfunction
#10
Ho-Yun Kim, Ji-Eun Lee, Ha-Na Oh, Ju-Whan Song, Sang-Youp Han, Jong-Soo Lee
AIM: To investigate the efficacy of combined topical 0.05% cyclosporine A (CsA; Restasis® , Allergan pharmaceuticals, USA) and 0.1% sodium hyaluronate treatment in dry eyes with meibomian gland dysfunction (MGD). METHODS: In a retrospective analysis, 53 patients (106 eyes) with MGD were enrolled and performed lid warm massage for 10min daily and be instilled preservative free sodium hyaluronate 0.1% eye drops 4 times daily. Patients were divided into subjects treated with topical 0...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675375/the-association-between-demodex-infestation-and-ocular-surface-manifestations-in-meibomian-gland-dysfunction
#11
Xiao-Bo Zhang, Ying-Hui Ding, Wei He
AIM: To investigate the association between ocular demodex folliculorum infestation and ocular surface manifestations in meibomian gland dysfunction (MGD). METHODS: Eight-six patients with MGD were enrolled. All enrolled subjects were tested in the following sequence: ocular surface disease index (OSDI), slit-lamp biomicroscope examination, corneal surface regularity index (SRI) and surface asymmetry index (SAI), tear fluid collection, fluorescein tear film break-up time (F-BUT), corneal fluorescein staining (CFS), Schirmer I test (SIT) and demodex folliculorum counting...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29649988/the-function-and-morphology-of-meibomian-glands-in-patients-with-thyroid-eye-disease-a-preliminary-study
#12
Chia-Yu Wang, Ren-Wen Ho, Po-Chiung Fang, Hun-Ju Yu, Chun-Chih Chien, Chang-Chun Hsiao, Ming-Tse Kuo
BACKGROUND: To investigate function and morphology of the meibomian gland (MG) in patients with thyroid eye disease (TED). METHODS: In this prospective case series study, patients with unilateral or bilateral TED were consecutively enrolled. The diagnosis of TED was based on the typical orbital findings and/or radiographic evidence. The disease activity of TED was classified according to the clinical activity score (CAS). Degrees of lagophthalmos and exophthalmos, blinking rates, and results of the Schirmer test 1 were also recorded...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29627826/meibomian-gland-dysfunction-in-primary-and-secondary-sj%C3%A3-gren-syndrome
#13
David A Sullivan, Reza Dana, Rose M Sullivan, Kathleen L Krenzer, Afsun Sahin, Beril Arica, Yang Liu, Wendy R Kam, Athena S Papas, Jennifer M Cermak
PURPOSE: We hypothesized that women with primary (pSS) and secondary Sjögren syndrome (sSS; with systemic lupus erythematosus [SLE] or rheumatoid arthritis [RA]) have meibomian gland dysfunction (MGD). We sought to test our hypothesis. METHODS: Subjects with pSS, sSS + SLE, sSS + RA, and non-SS-related MGD were recruited from the Sjögren's Syndrome Foundation or outpatient clinics at Tufts University School of Dental Medicine or Brigham and Women's Hospital. The control population was recruited from the Greater Boston area...
2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29573862/-ocular-surface-aging-pathophysiology-and-consequences-for-management
#14
REVIEW
T Audelan, M Legrand, M M'Garrech, A-L Best, E Barreau, M Labetoulle, A Rousseau
All the components of the ocular surface and the lacrimal system are affected by aging. Aging induces lacrimal gland fibrosis, Meibomian gland dysfunction, loss of corneal sensitivity, decreased corneal cell density, impairment of immune defences, increased local inflammation associated with hormonal changes, conjunctivochalasis, lid abnormalities, etc. Furthermore, homeostasis of the ocular surface may be altered by various age-related systemic comorbidities and iatrogenic interventions. Altogether, aging is considered the most predominant risk factor for dry eye disease...
March 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29563688/the-use-of-tea-tree-oil-in-treating-blepharitis-and-meibomian-gland-dysfunction
#15
Thuraya Noaman Maher
INTRODUCTION: Blepharitis and meibomian gland dysfunction are chronic inflammatory conditions with overlapping pathophysiology and symptomatology. Both microbial infection and seborrhea contribute to the pathophysiology and both may benefit from treatment with tea tree oil (TTO). We evaluated the therapeutic effect of eyelids scrubbing with TTO in a group of patients with lid margin disease. MATERIALS AND METHODS: Forty patients were recruited. Half of them received lid scrubbing with a TTO formula (Naviblef™) and the other half was treated by massage and cleansing...
January 2018: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29561352/meibomian-gland-dropout-in-hematological-patients-before-hematopoietic-stem-cell-transplantation
#16
Giuseppe Giannaccare, Francesca Bonifazi, Stefano Sebastiani, Mariarosaria Sessa, Marco Pellegrini, Mario Arpinati, Fabiana Moscardelli, Piera Versura, Emilio Campos
PURPOSE: To perform qualitative and quantitative analysis of meibomian gland (MG) dropout in hematological patients before hematopoietic stem cell transplantation (HSCT) and to correlate it with both ocular surface and hematological characteristics. METHODS: This prospective study included 46 consecutive patients undergoing HSCT and 30 age- and sex-matched healthy controls. Noninvasive meibography of the lower eyelid, meiboscore (Pult scale), Schirmer test type I, tear film breakup time, and corneal and conjunctival staining were measured...
March 20, 2018: Cornea
https://www.readbyqxmd.com/read/29543662/perioperative-ocular-parameters-associated-with-persistent-dry-eye-symptoms-after-cataract-surgery
#17
Young Joon Choi, Si Yoon Park, Ikhyun Jun, Moonjung Choi, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
PURPOSE: To evaluate perioperative dry eye (DE) syndrome and meibomian gland dysfunction (MGD) parameters associated with persistent DE symptoms after cataract surgery. METHODS: We enrolled patients who underwent uncomplicated cataract surgery without previous ocular comorbidities and previous use of ophthalmic treatment except for artificial tears at a single tertiary hospital. Lipid layer thickness, meibomian gland (MG) dropout, tear breakup time, Oxford staining score, lid margin abnormality, meibum quality, meibum expressibility, MG orifice obstruction, MGD stage, Ocular Surface Disease Index (OSDI), and Schirmer test score were prospectively assessed in order at baseline and 1 and 3 months postoperative...
June 2018: Cornea
https://www.readbyqxmd.com/read/29533687/assessment-of-tear-functions-in-patients-with-acne-rosacea-without-meibomian-gland-dysfunction
#18
Dilay Ozek, Özlem Evren Kemer, Ferda Artüz
PURPOSE: To evaluate the results of tear functions in acne rosacea. METHODS: This prospective study includes 64 eyes of 32 acne rosacea patients without blepharitis and meibomian gland dysfunction and 90 eyes of 45 patients as control group. Tear functions of all were evaluated with ocular surface disease index (OSDI) questionnaire, and measurements of tear osmolarity were performed by using TearLab, Schirmer I tests without anesthesia and fluorescein tear break-up time (TBUT)...
March 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29519880/meibomian-gland-dysfunction-and-keratopathy-are-associated-with-dry-eye-disease-in-aniridia
#19
Erlend Christoffer Sommer Landsend, Hilde Røgeberg Pedersen, Øygunn Aass Utheim, Jiaxin Xiao, Muhammed Yasin Adil, Behzod Tashbayev, Neil Lagali, Darlene Ann Dartt, Rigmor C Baraas, Tor Paaske Utheim
AIMS: To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort of patients with congenital aniridia. METHODS: Thirty-four Norwegian and one Danish subject with congenital aniridia and 21 healthy controls were examined. All subjects underwent an extensive dry eye examination, including evaluation of meibomian glands (MGs) by meibography, measurement of tear production and tear film osmolarity and grading of vital staining of the ocular surface...
March 8, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29505774/subtarsal-fibrosis-is-associated-with-ocular-surface-epitheliopathy-in-graft-versus-host-disease
#20
Ahmad Kheirkhah, Giulia Coco, Vannarut Satitpitakul, Reza Dana
PURPOSE: To evaluate occurrence of subtarsal fibrosis in patients with graft-vs-host disease (GVHD) and to determine its association with ocular surface epitheliopathy. DESIGN: Cross-sectional study. METHODS: We enrolled 40 patients with moderate or severe dry eye disease, including 20 patients with chronic ocular GVHD and 20 patients without (as the control group). All patients had a comprehensive ophthalmic assessment including evaluation for subtarsal fibrosis, corneal and conjunctival staining, tear break-up time (TBUT), and Schirmer test...
May 2018: American Journal of Ophthalmology
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