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Meibomian gland disease

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https://www.readbyqxmd.com/read/28448672/correlation-between-the-inflammatory-marker-hla-dr-and-signs-and-symptoms-in-moderate-to-severe-dry-eye-disease
#1
Françoise Brignole-Baudouin, Luisa Riancho, Dahlia Ismail, Maëva Deniaud, Mourad Amrane, Christophe Baudouin
Purpose: To investigate correlations of the inflammatory HLA-DR marker with clinical signs and symptoms commonly used to assess dry eye disease (DED) severity. Methods: Baseline data were collected from three clinical studies conducted on moderate to severe DED patients. Characteristics of DED were analyzed and correlations were performed in 311 patients. Data were analyzed after treatment with 1 mg/mL cyclosporine (CsA) and vehicle. We quantified HLA-DR by flow cytometry in impression cytology specimens...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28440253/evaluation-of-meibomian-gland-and-tear-film-changes-in-patients-with-pterygium
#2
Fen Ye, Fen Zhou, Yuan Xia, Xiaomin Zhu, Yan Wu, Zhenping Huang
BACKGROUND: Recent studies have demonstrated that pterygium has a close relationship with dry eye disease. This study is to determine abnormalities in meibomian gland and tear function in patients with pterygium and to assess the relationship between the variables. MATERIALS AND METHODS: Forty eyes from forty patients with primary nasal pterygium and forty eyes from forty volunteers without ocular pathologies were enrolled in this study. Ocular surface disease index scores, meibomian gland expression scores, lid margin abnormality scores, meiboscore, tear film breakup time (BUT), Schirmer test (SIT) value, and the lower tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) using Fourier domain optical coherence were performed...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28410360/estimation-of-prevalence-of-meibomian-gland-dysfunction-in-japan
#3
Shiro Amano, Kenji Inoue
PURPOSE: To estimate the prevalence of meibomian gland dysfunction (MGD) in the Japanese population using new diagnostic criteria, including lid margin abnormalities and signs of occlusion of the meibomian gland orifices as essential signs. METHODS: The participants were consecutive patients scheduled for cataract surgery at Inouye Eye Hospital. All participants were aged 50 years or older. The participants completed a symptoms questionnaire and underwent a comprehensive slit-lamp examination...
April 12, 2017: Cornea
https://www.readbyqxmd.com/read/28384900/efficacy-of-green-tea-extract-for-treatment-of-dry-eye-and-meibomian-gland-dysfunction-a-double-blind-randomized-controlled-clinical-trial-study
#4
Mahmood Nejabat, Salehi Ali Reza, Mehdi Zadmehr, Masoud Yasemi, Zahra Sobhani
INTRODUCTION: With an incidence rate of 9%, dry eye is a common problem of the ocular surface, especially in patients more than 40-year-old. Green tea extract has anti-oxidative, anti-bacterial, anti-androgen, and immunomodulatory properties. AIM: To evaluate the efficacy of green tea extract for treatment of patients with dry eye and Meibomian Gland Dysfunction (MGD). MATERIALS AND METHODS: In a double-blind randomized controlled clinical trial, 60 patients were selected within the age range of 30 to 70 years, and divided into two groups by blocked randomization method...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28368991/ocular-surface-parameters-predicting-patient-satisfaction-after-a-single-vectored-thermal-pulsation-procedure-for-management-of-symptomatic-meibomian-gland-dysfunction
#5
Allister Gibbons, Daniel Waren, Nilufer Yesilirmak, Kendra Davis, Felipe Valenzuela, Juan C Murillo, Victor L Perez
PURPOSE: To evaluate the ocular surface parameters that could predict patient satisfaction after single application of vectored thermal pulsation (VTP). METHODS: This is a retrospective interventional case series; it included consecutive patients who underwent bilateral VTP for management of symptomatic meibomian gland dysfunction (MGD). Patients received a full ocular surface evaluation. The outcome was patient subjective improvement during the first 3-4 months after 3 follow-up visits...
March 31, 2017: Cornea
https://www.readbyqxmd.com/read/28363775/the-human-meibomian-gland-epithelial-cell-line-as-a-model-to-study-meibomian-gland-dysfunction
#6
REVIEW
Ulrike Hampel, Fabian Garreis
The meibomian gland dysfunction (MGD) is the leading cause of dry eye disease (DED) throughout the world. The investigation of MGD lacks suitable in vivo and in vitro models. In 2010 a human meibomian gland epithelial cell line (HMGEC) was established, so far the only available meibomian gland cell line. The characterization of HMGEC is of major importance to clarify its suitability for studying the meibomian gland (patho)physiology in vitro. The current culture protocol and new concepts of HMGEC culture will be compared...
March 28, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28361356/-pathophysiology-of-atopic-blepharokeratoconjunctivitis
#7
T Lapp, P Maier, T Jakob, T Reinhard
Atopic dermatitis (AD) is a systemic inflammatory disease, which is characterized by pronounced eczema and pruritus. In addition to the involvement of the entire integument, the periocular lid skin and the surface of the eye are frequently involved. Ocular involvement may occur solely without dermatitis of facial or body skin. Pathophysiologically, besides a dysregulated immune response, genetic changes can occur in various dermal structural proteins which will lead to a disturbed skin barrier. Furthermore, there is a regular colonization with bacterial pathogens and an increased susceptibility for viral skin infections...
March 30, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28346280/conjunctivochalasis-and-related-factors-in-an-adult-population-of-iran
#8
Hassan Hashemi, Hadith Rastad, Mohammad Hassan Emamian, Akbar Fotouhi
OBJECTIVES: To determine the prevalence of conjunctivochalasis and its determinants in a middle-aged Iranian population. METHODS: This population-based study was conducted in the context of the second phase of Shahroud Eye Cohort Study in 2014. Of 4,737 participants aged 45 to 69 years who participated in the second phase, the data of 4,702 participants were available for this report. A diagnosis of conjunctivochalasis was made based on the physician's judgment on ophthalmic examinations...
March 24, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28338041/meibomian-gland-dysfunction-correlates-to-the-tear-film-instability-and-ocular-discomfort-in-patients-with-pterygium
#9
Huping Wu, Zhirong Lin, Fan Yang, Xie Fang, Nuo Dong, Shunrong Luo, Xumin Shang, Wei Li, Zuguo Liu
Pterygium is a very common disease in an eye clinic characterized by a benign proliferation of local conjunctiva that often crosses the limber of cornea and extends into corneal surface. Variety of studies has showed that pterygium is able to result in ocular discomfort and the change of ocular surface environment, such as dry eye. However, the link between abnormal tear film function and pterygium is controversial. Meibomian gland dysfunction (MGD) is a common cause of dry eye and ocular discomfort but is often neglected, which may be the missing link between dry eye and pterygium...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336260/the-analysis-of-human-conjunctival-epithelium-proteome-in-ocular-surface-diseases-using-impression-cytology-and-2d-dige
#10
Javier Soria, Arantxa Acera, Juan A Durán, Ana Boto-de-Los-Bueis, Almudena Del-Hierro-Zarzuelo, Nerea González, Rebeca Reigada, Tatiana Suárez
Conjunctival impression cytology samples from patients with meibomian gland dysfunction (MGD), dry eye (DE), and healthy subjects (CT) were collected for determination of the degree of squamous metaplasia (SM) by PAS-hematoxylin staining and for comparative proteomic analyses by 2D-DIGE. The protein spots with discriminant expression were identified by MALDI-TOF/TOF mass spectrometry. Three independent statistical studies were conducted: i). Analysis of differential protein expression between study groups: We observed increased expression of proteins S100A4, S100A8, retinal dehydrogenase-1, peroxiredoxin-1, annexin-A1, annexin-A2, α-enolase, and glutathione S-transferase-P in DE, whereas the highest expression of peroxiredoxin-6, actin cytoplasmic-1, peroxiredoxin-2, and heat shock protein HSP-90-α was observed in MGD; ii)...
March 20, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28321333/correlation-analysis-of-ocular-symptoms-and-signs-in-patients-with-dry-eye
#11
Hang Song, Mingzhou Zhang, Xiaodan Hu, Kaixiu Li, Xiaodan Jiang, Yan Liu, Huibin Lv, Xuemin Li
Purpose. To analyze the correlations between the ocular surface signs and symptoms in patients with dry eye. Methods. In this observational study, 176 dry eye patients, including 60 males and 116 females, were enrolled and their dry eye symptoms and ocular signs were observed. Partial correlation analysis was conducted between OSDI score and each ocular surface sign, and the correlations were further discussed in different age groups. Then multiple linear regression analysis was used to further explore the influence of these signs on OSDI score...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28316191/-in-vivo-confocal-microscopic-observation-of-corneal-changes-in-patients-with-chronic-stevens-johnson-syndrome-or-toxic-epidermal-necrolysis
#12
T T Gao, Y Li, J Liu, Q Long
Objective: To describe corneal alterations visible on in vivo confocal microscopy in patients with debilitating ocular sequelae caused by Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). Methods: Twenty-two eyes of 11 consecutive patients suffering from chronic SJS or TEN were studied using slit lamp and in vivo confocal microscopy in the Ophthalmology Outpatient Department of Peking Union Medical College Hospital from March 2014 to April 2015. Results: Dry eye with meibomian gland dysfunction (19 eyes of 10 patients, 86...
March 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28297170/meibomian-gland-disease-and-the-microbiotome-is-it-time-for-ocular-probiotics
#13
EDITORIAL
Stephanie Watson
No abstract text is available yet for this article.
March 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28295626/mechanical-meibomian-gland-squeezing-combined-with-eyelid-scrubs-and-warm-compresses-for-the-treatment-of-meibomian-gland-dysfunction
#14
Hun Lee, Minseo Kim, Si Yoon Park, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
BACKGROUND: The aim was to investigate the efficacy of mechanical meibomian gland squeezing combined with eyelid scrubs and warm compresses in participants with moderate and severe meibomian gland dysfunction (MGD). METHODS: In this prospective, uncontrolled, open label, intervention study, 32 eyes of 32 participants with moderate and severe MGD were treated with mechanical squeezing of meibomian glands in combination with eyelid scrubs and warm compresses. We evaluated tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, biomicroscopic examination of lid margins and meibomian glands, Ocular Surface Disease Index (OSDI) questionnaire and tear film lipid layer thickness determined via an interferometer before initiating treatment and after one month of treatment...
March 12, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28284957/proteolytic-activity-in-the-meibomian-gland-implications-to-health-and-disease
#15
REVIEW
Pablo Argüeso
The function of the meibomian gland in the upper and lower eyelids is critical to maintaining homeostasis at the ocular surface. Highly specialized meibocytes within the gland must differentiate and accumulate intracellular lipid droplets that are released into the tear film following rupture of the cell membrane. Proteases and their inhibitors have been recognized as key players in remodeling extracellular matrices and promoting the normal integrity of glandular tissue. They modulate a wide range of biological processes, such as cell proliferation and differentiation, and can contribute to disease when aberrantly expressed...
March 8, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28282067/evaluation-of-dry-eye-and-meibomian-gland-dysfunction-with-meibography-in-vitiligo
#16
M Palamar, P Kiyat, I Ertam, A Yagci
PurposeTo evaluate the dry eye and meibomian gland dysfunction (MGD) of vitiligo patients with meibography.MethodsTwenty eyes of 20 vitiligo patients (Group 1) and 20 eyes of 20 healthy individuals (Group 2) were enrolled. All subjects had undergone a comprehensive ophthalmic examination including corneal and conjunctival fluorescein staining (Oxford scale scoring), tear film break-up time (T-BUT), Schirmer 1 test, Ocular Surface Disease Index (OSDI) score assessment, and upper and lower eyelid meibography using infrared captures of a biomicroscope (Topcon, SL-D701, IJssel, The Netherlands)...
March 10, 2017: Eye
https://www.readbyqxmd.com/read/28257381/effect-of-sleep-position-on-the-ocular-surface
#17
David Alevi, Henry D Perry, Alexander Wedel, Eric Rosenberg, Limor Alevi, Eric D Donnenfeld
PURPOSE: Dry eye disease is a multifactorial disease with numerous well-documented risk factors. However, to date, sleep position has not been associated with this condition. After observing patients in our practice, we believe that the sleep position in some cases may significantly affect dry eye and meibomian gland dysfunction (MGD). METHODS: This is a single-centered, cross-sectional, noninterventional, institutional review board-approved, single-masked, nonrandomized study of 100 patients whose complaints were related to dry eye disease and a control group of 25 age-matched asymptomatic patients...
May 2017: Cornea
https://www.readbyqxmd.com/read/28241316/clinic-based-study-on-meibomian-gland-dysfunction-in-japan
#18
Shiro Amano, Kenji Inoue
Purpose: To estimate the prevalence of meibomian gland dysfunction (MGD) in the Japanese population. Methods: We undertook a clinical study on the prevalence of MGD in Japan using the same diagnostic criteria as a previous population-based study conducted in Spanish Caucasians. The participants were consecutive patients scheduled for cataract surgery at Inouye Eye Hospital. All participants were aged 50 years or older. Patients completed a symptoms questionnaire and underwent a comprehensive slit-lamp examination...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28219733/meibocyte-differentiation-and-renewal-insights-into-novel-mechanisms-of-meibomian-gland-dysfunction-mgd
#19
REVIEW
Ho Sik Hwang, Geraint J Parfitt, Donald J Brown, James V Jester
This paper reviews our current understanding of age-related meibomian gland dysfunction (MGD) and the role of the nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARγ), in the regulation of meibomian gland function, meibocyte differentiation and lipid synthesis. The studies suggest that PPARγ is a master regulator of meibocyte differentiation and function, whose expression and nuclear signaling coupled with meibocyte renewal is altered during aging, potentially leading to atrophy of the meibomian gland as seen in clinical MGD...
February 17, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28211183/a-comparison-of-the-self-reported-dry-eye-practices-of-new-zealand-optometrists-and-ophthalmologists
#20
Ally L Xue, Laura E Downie, Susan E Ormonde, Jennifer P Craig
PURPOSE: The aim of this cross-sectional survey was to evaluate the self-reported clinical practices of New Zealand optometrists and ophthalmologists with respect to the diagnosis and management of dry eye disease. It also sought to compare these behaviours with the current research evidence base. METHODS: An anonymous survey was distributed electronically to New Zealand eye care clinicians (optometrists n = 614, ophthalmologists n = 113) to determine practitioner interest in dry eye disease, practice experience, practice modality, preferred diagnostic and management strategies, and information used to guide patient care...
March 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
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