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NGAL review

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https://www.readbyqxmd.com/read/28076311/biomarkers-of-acute-kidney-injury-the-pathway-from-discovery-to-clinical-adoption
#1
Kianoush Kashani, Wisit Cheungpasitporn, Claudio Ronco
Acute kidney injury (AKI) is a common complication of critical illnesses and has a significant impact on outcomes, including mortality and morbidities. Unfortunately, apart from prophylactic measures, no effective treatment for this syndrome is known. Therefore, early recognition of AKI not only can provide better opportunities for preventive interventions, but also opens many gates for research and development of effective therapeutic options. Over the last few years, several new AKI biomarkers have been discovered and validated to improve early detection, differential diagnosis, and differentiation of patients into risk groups for progressive renal failure, need for renal replacement therapy (RRT), or death...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28013112/urine-interleukin-18-and-lipocalin-2-are-biomarkers-of-acute-tubular-necrosis-in-patients-with-cirrhosis-a-systematic-review-and-meta-analysis
#2
Jeremy Puthumana, Xavier Ariza, Justin M Belcher, Isabel Graupera, Pere Ginès, Chirag R Parikh
BACKGROUND & AIMS: Acute kidney injury (AKI) is a common complication in patients with cirrhosis that increases mortality. The most common causes of AKI in these patients are prerenal azotemia, acute tubular necrosis (ATN), and hepatorenal syndrome; it is important to determine the etiology of AKI to select the proper treatment and predict patient outcome. Urine biomarkers could be used to differentiate between patients with ATN and functional causes of AKI. We performed a systemic review and meta-analysis of published studies to determine whether urine levels of interleukin 18 (IL18) and lipocalin 2 (LCN2 or NGAL) associate with development of ATN in patients with cirrhosis...
December 21, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27907168/are-urinary-tubular-injury-markers-useful-in-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#3
Le-Ting Zhou, Lin-Li Lv, Ming-Ming Pan, Yu-Han Cao, Hong Liu, Ye Feng, Hai-Feng Ni, Bi-Cheng Liu
BACKGROUND: Adverse outcome of chronic kidney disease, such as end stage renal disease, is a significant burden on personal health and healthcare costs. Urinary tubular injury markers, such as NGAL, KIM-1 and NAG, could provide useful prognostic value for the early identification of high-risk patients. However, discrepancies between recent large prospective studies have resulted in controversy regarding the potential clinical value of these markers. Therefore, we conducted the first meta-analysis to provide a more persuasive argument to this debate...
2016: PloS One
https://www.readbyqxmd.com/read/27906719/diagnosis-of-cardiac-surgery-associated-acute-kidney-injury-from-functional-to-damage-biomarkers
#4
Wim Vandenberghe, Jorien De Loor, Eric A J Hoste
PURPOSE OF REVIEW: Acute kidney injury (AKI) occurs in up to 30% after cardiac surgery and is associated with adverse outcome. Currently, cardiac surgery-associated acute kidney injury (CSA-AKI) is diagnosed by Kidney Disease: Improving Global Outcomes criteria based on creatinine and urine output. To detect and treat AKI earlier, various biomarkers have been evaluated. This review addresses the current position of the two damage biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and [TIMP-2] [IGFBP7] in clinical practice...
February 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27771693/kidney-injury-marker-1-and-neutrophil-gelatinase-associated-lipocalin-in-chronic-kidney-disease
#5
Esmeralda Castillo-Rodriguez, Raul Fernandez-Prado, Catalina Martin-Cleary, Maria Soledad Pizarro-Sánchez, Maria Dolores Sanchez-Niño, Ana Belen Sanz, Beatriz Fernandez-Fernandez, Alberto Ortiz
The current categorization of chronic kidney disease (CKD) is based on biomarkers of the glomerular function (estimated glomerular filtration rate, eGFR) and injury (urinary albumin creatinine ratio, UACR) and provides information on the risk of death and of progression of kidney disease. However, there are gaps in knowledge regarding the risk stratification of elderly patients with eGFR 45-60 ml/min/1.73 m2 and of younger patients with higher eGFR but physiological albuminuria. In this regard, most of the kidney cell mass is composed of tubules...
October 22, 2016: Nephron
https://www.readbyqxmd.com/read/27744618/plasma-neutrophil-gelatinase-associated-lipocalin-a-marker-of-acute-pyelonephritis-in-children
#6
Byung Kwan Kim, Hyung Eun Yim, Kee Hwan Yoo
OBJECTIVES: This study was designed to compare the diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin (NGAL) with procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) for predicting acute pyelonephritis (APN) in children with febrile urinary tract infections (UTIs). MATERIALS AND METHODS: In total, 138 children with febrile UTIs (APN 59, lower UTI 79) were reviewed retrospectively. Levels of NGAL, PCT, CRP, and WBCs in blood were measured on admission...
October 15, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27610713/neutrophils-in-ulcerative-colitis-a-review-of-selected-biomarkers-and-their-potential-therapeutic-implications
#7
Daniel Muthas, Anna Reznichenko, Clare A Balendran, Gerhard Böttcher, Ib Groth Clausen, Carina Kärrman Mårdh, Tomas Ottosson, Mohib Uddin, Thomas T MacDonald, Silvio Danese, Mark Berner Hansen
OBJECTIVES: This review article describes the role of neutrophils in mucosal injury and the resulting crypt abscesses characteristic of ulcerative colitis. We also review selected biomarkers for monitoring neutrophil presence and activity in the mucosa as well as their potential as therapeutic targets. MATERIAL: We have collated and selectively reviewed data on the most prominent well-established and emerging neutrophil-related biomarkers and potential therapeutic targets (calprotectin, lactoferrin, CXCR1, CXCR2, MMP-9, NGAL, elafin, HNE, pANCAs, MPO, CD16, CD177, CD64, HNPs, SLPI and PTX3) in ulcerative colitis...
February 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27457509/diabetic-nephropathy-in-type-1-diabetes-a-review-of-early-natural-history-pathogenesis-and-diagnosis
#8
Nektaria Papadopoulou-Marketou, George P Chrousos, Christina Kanaka-Gantenbein
Diabetic nephropathy constitutes a devastating complication in patients with type 1 diabetes mellitus, and its diagnosis is traditionally based on microalbuminuria. The aim of this review is to update through the medical literature the suggested early natural course of diabetic nephropathy, the theories behind the pathways of its pathogenesis, and its diagnosis. Poor glycemic control, dyslipidemia, smoking, advanced glycation end products, and environmental and genetic clues play an important role in the development of diabetic nephropathy...
July 25, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27293888/urinary-markers-of-tubular-injury-in-early-diabetic-nephropathy
#9
REVIEW
Temesgen Fiseha, Zemenu Tamir
Diabetic nephropathy (DN) is a common and serious complication of diabetes associated with adverse outcomes of renal failure, cardiovascular disease, and premature mortality. Early and accurate identification of DN is therefore of critical importance to improve patient outcomes. Albuminuria, a marker of glomerular involvement in early renal damage, cannot always detect early DN. Thus, more sensitive and specific markers in addition to albuminuria are needed to predict the early onset and progression of DN. Tubular injury, as shown by the detection of tubular injury markers in the urine, is a critical component of the early course of DN...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27275158/risk-factors-for-acute-kidney-injury-after-coronary-artery-bypass-surgery-and-its-detection-using-neutrophil-gelatinase-associated-lipocalin
#10
Oruç Alper Onk, Didem Onk, Fatih Ozcelik, Murat Gunay, Kultigin Turkmen
INTRODUCTION: Acute kidney injury (AKI) is an important complication of cardiac surgery due to its high mortality. The aim of the present study was to detect the factors leading to AKI in patients who underwent coronary artery bypass surgery (CABS) and also to determine the optimal timing for detecting AKI using the biomarker neutrophil gelatinase-associated lipocalin (NGAL). MATERIALS AND METHODS: The records of 375 patients who underwent CABS were reviewed in this case-control study...
May 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27255130/hepatic-ischemia-reperfusion-injury-a-systematic-review-of-literature-and-the-role-of-current-drugs-and-biomarkers
#11
Marco Cannistrà, Michele Ruggiero, Alessandra Zullo, Giuseppe Gallelli, Simone Serafini, Mazzitelli Maria, Agostino Naso, Raffaele Grande, Raffaele Serra, Bruno Nardo
Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic IRI can seriously impair liver function, even producing irreversible damage, which causes a cascade of multiple organ dysfunction. Many factors, including anaerobic metabolism, mitochondrial damage, oxidative stress and secretion of ROS, intracellular Ca(2+) overload, cytokines and chemokines produced by KCs and neutrophils, and NO, are involved in the regulation of hepatic IRI processes...
September 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27017333/is-plasma-neutrophil-gelatinase-associated-lipocalin-a-predictive-biomarker-for-acute-kidney-injury-in-sepsis-patients-a-systematic-review-and-meta-analysis
#12
Sollip Kim, Hyun-Jung Kim, Hyeong-Sik Ahn, Ji Yang Song, Tae-Hyun Um, Chong-Rae Cho, Hoon Jung, Hyeon-Kyoung Koo, Joo Hyun Park, Sung-Soon Lee, Hye Kyeong Park
PURPOSE: Neutrophil gelatinase-associated lipocalin (NGAL) is a useful biomarker for early diagnosis of acute kidney injury (AKI). However, the diagnostic value of NGAL for predicting AKI in sepsis patients is unclear. METHODS: MEDLINE, EMBASE, and Cochrane Library databases were searched to identify research publications. RESULTS: Twelve studies from 9 countries including a total of 1582 patients, of whom 315 (19.9%) developed AKI, were included in the study; plasma NGAL levels were significantly higher in adult sepsis patients with AKI than in those without AKI (mean difference, 274...
June 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27011557/neutrophil-gelatinase-associated-lipocalin-ngal-as-a-biomarker-does-it-apply-in-abdominal-aortic-aneurysms-a-review-of-literature
#13
REVIEW
Georgios Karaolanis, Demetrios Moris, Viktoria-Varvara Palla, Euridiki Karanikola, Chris Bakoyiannis, Sotirios Georgopoulos
Neutrophil gelatinase associated lipocalin (NGAL) as a protein derived from neutrophils has recently been the field of investigation in a wide range of diseases (renal disease, coronary artery disease, etc). The MEDLINE/PubMed database was searched for publications with the medical subject heading "NGAL" and keywords "Abdominal aortic aneurysm (AAA)," "biomarker," and "growth". We restricted our search to date. In this review, we included 38 articles and abstracts that were accessible and available in English...
December 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/26952930/the-cardiac-surgery-associated-neutrophil-gelatinase-associated-lipocalin-csa-ngal-score-a-potential-tool-to-monitor-acute-tubular-damage
#14
Hilde R H de Geus, Claudio Ronco, Michael Haase, Laurent Jacob, Andrew Lewington, Jean-Louis Vincent
Acute kidney injury (AKI), defined as a rise in serum creatinine (functional AKI), is a frequent complication after cardiac surgery. The expression pattern of acute tubular damage biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) has been shown to precede functional AKI and, therefore, may be useful to identify very early tubular damage. The term subclinical AKI represents acute tubular damage in the absence of functional AKI (biomarker positivity without a rise in serum creatinine) and affects hard outcome measures...
June 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26882802/could-blood-neutrophil-gelatinase-associated-lipocalin-ngal-be-a-diagnostic-marker-for-acute-kidney-injury-in-neonates-a-systemic-review-and-meta-analysis
#15
REVIEW
Lina Jiang, Hong Cui
BACKGROUND: Blood neutrophil gelatinase-associated lipocalin (NGAL) has been shown to be helpful for acute kidney injury (AKI) in pediatric patients and adults. Whether this is true in neonates remains unclear. METHODS: A systemic review and diagnostic meta-analysis was performed. Keywords included blood NGAL/serum NGAL, neonate/newborn, and AKI/acute kidney failure. Eligible studies measured blood or serum NGAL levels in neonates with AKI (first 30 days of life)...
2015: Clinical Laboratory
https://www.readbyqxmd.com/read/26880194/diagnosis-and-prognosis-of-neutrophil-gelatinase-associated-lipocalin-for-acute-kidney-injury-with-sepsis-a-systematic-review-and-meta-analysis
#16
An Zhang, Ying Cai, Peng-Fei Wang, Jian-Ning Qu, Zhen-Chun Luo, Xiao-Dong Chen, Bin Huang, Yi Liu, Wen-Qi Huang, Jing Wu, Yue-Hui Yin
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as an early biomarker for prediction of acute kidney injury (AKI). However, the utility of NGAL to predict the occurrence of AKI in septic patients remains controversial. We performed a systematic review and meta-analysis to evaluate the evidence on diagnosis of sepsis AKI and the prediction of other clinical outcomes. METHOD: The MEDLINE, EMBASE, Cochrane Library, Wanfang, and CNKI databases were systematically searched up to August 19, 2015...
February 16, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26860999/evaluation-of-novel-biomarkers-of-acute-kidney-injury-the-possibilities-and-limitations
#17
Branislava Medić, Branislav Rovcanin, Katarina Savic Vujovic, Danilo Obradovic, Dusan Duric, Milica Prostran
Despite the recent findings concerning pathogenesis and novel therapeutic strategies, the mortality rate in patients with acute kidney injury (AKI) remains very high. Early detection of patients with impaired renal function may help to ensure more aggresive treatment and to improve clinical outcome. Serum creatinine is still gold standard of kidney injury, although it is well known as an insensitive and unreliable biomarker (for example, its concentration does not increase significantly until about half of the kidney function is lost)...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26804756/current-paradigm-for-ischemia-in-kidney-surgery
#18
REVIEW
Maria C Mir, Nicola Pavan, Dipen J Parekh
PURPOSE: Partial nephrectomy is the accepted standard of care for treatment of patients with small renal masses. The primary goal while performing partial nephrectomy is cancer control with a secondary important goal of maximizing renal function preservation with minimal perioperative morbidity. Recent studies have highlighted the importance of renal parenchymal quality and quantity postoperatively rather than duration of ischemia in determining long-term renal function. We review the available data regarding perioperative renal function optimization with special interest in ischemia during partial nephrectomy, highlighting the controversies and establishing future lines of investigation...
June 2016: Journal of Urology
https://www.readbyqxmd.com/read/26671823/the-potential-of-lipocalin-2-ngal-as-biomarker-for-inflammatory-and-metabolic-diseases
#19
REVIEW
Vanessa Abella, Morena Scotece, Javier Conde, Rodolfo Gómez, Ana Lois, Jesús Pino, Juan J Gómez-Reino, Francisca Lago, Ali Mobasheri, Oreste Gualillo
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis...
2015: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/26525204/novel-roles-of-androgen-receptor-epidermal-growth-factor-receptor-tp53-regulatory-rnas-nf-kappa-b-chromosomal-translocations-neutrophil-associated-gelatinase-and-matrix-metalloproteinase-9-in-prostate-cancer-and-prostate-cancer-stem-cells
#20
REVIEW
William H Chappell, Stephen L Abrams, Kvin Lertpiriyapong, Timothy L Fitzgerald, Alberto M Martelli, Lucio Cocco, Dariusz Rakus, Agnieszka Gizak, David Terrian, Linda S Steelman, James A McCubrey
Approximately one in six men will be diagnosed with some form of prostate cancer in their lifetime. Over 250,000 men worldwide die annually due to complications from prostate cancer. While advancements in prostate cancer screening and therapies have helped in lowering this statistic, better tests and more effective therapies are still needed. This review will summarize the novel roles of the androgen receptor (AR), epidermal growth factor receptor (EGFR), the EGFRvIII variant, TP53, long-non-coding RNAs (lncRNAs), microRNAs (miRs), NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, (NGAL), matrix metalloproteinase-9 (MMP-9), the tumor microenvironment and cancer stem cells (CSC) have on the diagnosis, development and treatment of prostate cancer...
January 2016: Advances in Biological Regulation
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