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Xiaowei Hong, Ramkumar T Annamalai, Tyler S Kemerer, Cheri X Deng, Jan P Stegemann
Both static and time-dependent mechanical factors can have a profound impact on cell and tissue function, but it is challenging to measure the mechanical properties of soft materials at the scale which cells sense. Multimode ultrasound viscoelastography (MUVE) uses focused ultrasound pulses to both generate and image deformations within soft hydrogels non-invasively, at sub-millimeter resolution, and in 3D. The deformation and strain over time data are used to extract quantitative parameters that describe both the elastic and viscoelastic properties of the material...
June 2, 2018: Biomaterials
Siavash Kazemirad, Simon Bernard, Samuel Hybois, An Tang, Guy Cloutier
Ultrasound shear wave elastography methods are commonly used for estimation of mechanical properties of soft biological tissues in diagnostic medicine. A limitation of most currently used elastography methods is that they yield only the shear storage modulus ( G(') ) but not the loss modulus ( G('') ). Therefore, no information on viscosity or loss tangent (tan δ) is provided. In this paper, an ultrasound shear wave viscoelastography method is developed for model-independent quantification of frequency-dependent viscoelastic complex shear modulus of macroscopically homogeneous tissues...
September 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
John J Pitre, Leo B Koziol, Grant H Kruger, Alan Vollmer, Jonathan Ophir, Jean-Jacques Ammann, William F Weitzel, Joseph L Bull
Management of fluid overload in patients with end-stage renal disease represents a unique challenge to clinical practice because of the lack of accurate and objective measurement methods. Currently, peripheral edema is subjectively assessed by palpation of the patient's extremities, ostensibly a qualitative indication of tissue viscoelastic properties. New robust quantitative estimates of tissue fluid content would allow clinicians to better guide treatment, minimizing reactive treatment decision making. Ultrasound viscoelastography (UVE) can be used to estimate strain in viscoelastic tissue, deriving material properties that can help guide treatment...
September 2016: Ultrasound in Medicine & Biology
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