Wenqiang Li, Rui Chen, Laipeng Feng, Xinglun Dang, Jiewei Liu, Tengfei Chen, Jinfeng Yang, Xi Su, Luxian Lv, Tao Li, Zhijun Zhang, Xiong-Jian Luo
Anxiety disorders are the most prevalent mental disorders. However, the genetic etiology of anxiety disorders remains largely unknown. Here we conducted a genome-wide meta-analysis on anxiety disorders by including 74,973 (28,392 proxy) cases and 400,243 (146,771 proxy) controls. We identified 14 risk loci, including 10 new associations near CNTNAP5, MAP2, RAB9BP1, BTN1A1, PRR16, PCLO, PTPRD, FARP1, CDH2 and RAB27B. Functional genomics and fine-mapping pinpointed the potential causal variants, and expression quantitative trait loci analysis revealed the potential target genes regulated by the risk variants...
November 9, 2023: Nature Human Behaviour