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JOURNAL ARTICLE
Isaac Ignacio-Rodríguez, Roberto Barcala-Furelos, Ezequiel Rey, Marcos Sanmartín-Montes
Coastal environments present dynamic challenges necessitating rapid and efficient responses during aquatic emergencies. Lifeguards, as pivotal links in the intervention chain, rely on various tools, with rescue time being paramount. The choice of fins, specifically long versus short ones, plays a critical role in optimizing lifeguard performance during rescues. This randomized cross-over study explores the impact of flipper size on ocean rescues, employing a sample of 14 lifeguards. Long fins (LFs) and short fins (SFs) were compared in terms of rescue time (RT) and physiological load (PL)...
April 19, 2024: Journal of Functional Morphology and Kinesiology
#2
JOURNAL ARTICLE
Isabel E Sánchez-Adriá, Gemma Sanmartín, Jose A Prieto, Francisco Estruch, Francisca Randez-Gil
The increasing popularity of home brewing and the fast evolution of craft beer companies have fuelled the interest in novel yeasts as the main actors diversifying the beer portfolio. Here, we have characterized the thermal tolerance and brewing-related features of two sourdough (SD) isolates of Saccharomyces cerevisiae , SDy01 and SDy02, at different temperatures, 20 and 37 °C, comparing them with commercial brew strains, AaB and kNB. The SD strains exhibited tolerance to the main brewing-related stress conditions and increased growth rates and lower lag phases than the reference beer strains at both temperatures...
March 29, 2024: Foods (Basel, Switzerland)
#3
REVIEW
Pablo García Molina, Adrian Saura-Sanmartin, Jose Berna, Jose Antonio Teruel, Jose Luis Muñoz Muñoz, Jose Neptuno Rodríguez López, Francisco García Cánovas, Francisco García Molina
Tyrosinase is a copper oxidase enzyme which catalyzes the first two steps in the melanogenesis pathway, L-tyrosine to L-dopa conversion and, then, to o-dopaquinone and dopachrome. Hypopigmentation and, above all, hyperpigmentation issues can be originated depending on their activity. This enzyme also promotes the browning of fruits and vegetables. Therefore, control of their activity by regulators is research topic of great relevance. In this work, we consider the use of inhibitors of monophenolase and diphenolase activities of the enzyme in order to accomplish such control...
April 10, 2024: International Journal of Biological Macromolecules
#4
JOURNAL ARTICLE
Enrique Dorronzoro-Zubiete, Jesús Castro-Marrero, Jorge Ropero, José Luis Sevillano-Ramos, María Dolores Hernández, Ramon Sanmartin Sentañes, Jose Alegre-Martin, Patricia Launois-Obregón, Isabel Martin-Garrido, Asuncion Luque Budia, Juan R Lacalle-Remigio, Luis Béjar Prado, Octavio Rivera Romero
BACKGROUND: Fatigue is the most common symptom in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID, impacting patients' quality of life; however, there is currently a lack of evidence-based context-aware tools for fatigue self-management in these populations. OBJECTIVE: This study aimed to (1) address fatigue in ME/CFS and long COVID through the development of digital mobile health solutions for self-management, (2) predict perceived fatigue severity using real-time data, and (3) assess the feasibility and potential benefits of personalized digital mobile health solutions...
April 12, 2024: JMIR Research Protocols
#5
JOURNAL ARTICLE
Joan Carles Domingo, Federica Battistini, Begoña Cordobilla, Maria Cleofé Zaragozá, Ramón Sanmartin-Sentañes, Jose Alegre-Martin, Trinitat Cambras, Jesus Castro-Marrero
BACKGROUND: Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers and illness severity in these conditions. METHODS: This single-site, prospective, cross-sectional, pilot cohort study aimed to distinguish between the two patient populations by using self-reported outcome measures and circulating biomarkers of endothelial function and systemic inflammation status...
April 10, 2024: Journal of Translational Medicine
#6
REVIEW
María Teresa Fernández Figueras, Jacques Alzoghby-Abi Chaker, Miriam Fernandez-Parrado, Adriana García Herrera, María Garrido, Miguel Ángel Idoate Gastearena, Mar Llamas-Velasco, Carlos Monteagudo, José Onrubia, Noelia Pérez Muñoz, Juan José Ríos-Martín, José Luis Rodríguez Peralto, Eduardo Rozas Muñoz, Onofre Sanmartín, Ángel Santos-Briz, Carles Saus, José Manuel Suárez Peñaranda, Verónica Velasco Benito, María José Beato Merino, Ángel Fernandez-Flores
This is the second article in a two-part series published in this journal, in which we examine the histopathological characteristics, as well as the differential diagnosis, of the main entities that present as cystic and pseudocystic structures in cutaneous biopsy. In this second article, we address ciliated cutaneous cysts, branchial cysts, Bartholin's cysts, omphalomesenteric cysts, thymic cysts, thyroglossal duct cysts, synovial cysts, and median raphe cysts, as well as mucocele, ganglion, and auricular and digital myxoid pseudocysts...
2024: Revista Española de Patología
#7
JOURNAL ARTICLE
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Magdalena Andryszkiewicz, Laura Sanmartin Cabo, Ana Criado, Cristina Fernàndez-Fraguas, Yi Liu, Silvia Peluso, Rita Ferreira de Sousa, Andrew Chesson
This assessment addresses a food enzyme preparation consisting of the immobilised non-viable cells of the non-genetically modified bacterium identified by the applicant (Samyang Corporation) as Microbacterium foliorum strain SYG27B. This strain produces the enzyme D-psicose 3-epimerase (EC 5.1.3.30). The food enzyme preparation is used for the isomerisation of fructose to produce the speciality carbohydrate D-allulose (synonym D-psicose). Since the hazard identification and characterisation could not be made and the identity of the production organism could not be established, the Panel was unable to complete the assessment of this food enzyme preparation containing D-psicose 3-epimerase...
April 2024: EFSA journal
#8
JOURNAL ARTICLE
Julia Pastor-Fernández, Neus Sanmartín, Maria Manresa, Cédric Cassan, Pierre Pétriacq, Yves Gibon, Jordi Gamir, Beatriz Romero Rodriguez, Araceli G Castillo, Miguel Cerezo, Victor Flors, Paloma Sánchez-Bel
Plant defense peptides are paramount endogenous danger signals secreted after a challenge intensifying the plant immune response. The peptidic hormone Systemin (Sys) was shown to participate in resistance in several plant-pathosystems, although the mechanisms behind Sys-IR when exogenously applied remain elusive. We performed proteomic, metabolomic and enzymatic studies to decipher the Sys-induced changes in tomato plants either in the absence or the presence of Botrytis cinerea infection. Sys-treatments triggered direct proteomic rearrangement mostly involved in carbon metabolism and photosynthesis...
April 6, 2024: Journal of Experimental Botany
#9
JOURNAL ARTICLE
Eva Muñoz, Javier Cañueto Álvarez, Josep Oriol Bermejo Segú, Almudena García Castaño, Vanessa Gabriela Jerviz Guía, Ana María López López, Susana Puig Sardá, Onofre Sanmartín Jiménez, Ainara Soria Rivas, Paula Gratal, Teresa Pardo, Alvaro Rogado, Alfonso Berrocal
No abstract text is available yet for this article.
April 5, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#10
JOURNAL ARTICLE
Longitudinal Study of Different Progression Patterns in High-Risk Cutaneous Squamous Cell Carcinoma.
A Tejera-Vaquerizo, J Cañueto, Á Gómez-Tomás, J Santos-Juanes, S Ribero, G Avallone, A Jaka, C Ferrandiz-Pulido, A Toll, O Sanmartín
BACKGROUND AND OBJECTIVE: Cutaneous squamous cell carcinoma (cSCC) is the second leading cause of skin cancer mortality in Europe. Few studies have analyzed the different pathways of this tumor progression in its natural history. The main objective of this study was to analyze the different metastatic and progression pathways and their temporal occurrence in the evolution of cSCC. MATERIAL AND METHOD: We conducted a multicenter, retrospective, and observational study of consecutive high-risk sSCCs included in the SQUAMATA project...
March 28, 2024: Actas Dermo-sifiliográficas
#11
JOURNAL ARTICLE
Charlotte Lanièce Delaunay, Iván Martínez-Baz, Noémie Sève, Lisa Domegan, Clara Mazagatos, Silke Buda, Adam Meijer, Irina Kislaya, Catalina Pascu, AnnaSara Carnahan, Beatrix Oroszi, Maja Ilić, Marine Maurel, Aryse Melo, Virginia Sandonis Martín, Camino Trobajo-Sanmartín, Vincent Enouf, Adele McKenna, Gloria Pérez-Gimeno, Luise Goerlitz, Marit de Lange, Ana Paula Rodrigues, Mihaela Lazar, Neus Latorre-Margalef, Gergő Túri, Jesús Castilla, Alessandra Falchi, Charlene Bennett, Virtudes Gallardo, Ralf Dürrwald, Dirk Eggink, Raquel Guiomar, Rodica Popescu, Maximilian Riess, Judit Krisztina Horváth, Itziar Casado, Mª Del Carmen García, Mariëtte Hooiveld, Ausenda Machado, Sabrina Bacci, Marlena Kaczmarek, Esther Kissling
BackgroundScarce European data in early 2021 suggested lower vaccine effectiveness (VE) against SARS-CoV-2 Omicron lineages than previous variants.AimWe aimed to estimate primary series (PS) and first booster VE against symptomatic BA.1/BA.2 infection and investigate potential biases.MethodsThis European test-negative multicentre study tested primary care patients with acute respiratory symptoms for SARS-CoV-2 in the BA.1/BA.2-dominant period. We estimated PS and booster VE among adults and adolescents (PS only) for all products combined and for Comirnaty alone, by time since vaccination, age and chronic condition...
March 2024: Euro Surveillance
#12
JOURNAL ARTICLE
Adrián Mosquera Orgueira, Olga Krali, Carlos Pérez Míguez, Andrés Peleteiro Raíndo, José Ángel Díaz Arias, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Manuel Fernández Sanmartín, Daniel Sinnet, Mats Heyman, Gudmar Lönnerholm, Ulrika Norén-Nyström, Kjeld Schmiegelow, Jessica Nordlund
Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatment outcomes, relapses still pose significant risks of mortality and long-term complications. To address this challenge, we employed a supervised machine learning technique, specifically random survival forests, to predict the risk of relapse and mortality using array-based DNA methylation data from a cohort of 763 pediatric ALL patients treated in Nordic countries. The relapse risk predictor (RRP) was constructed based on 16 CpG sites, demonstrating c-indexes of 0...
March 28, 2024: Clinical Epigenetics
#13
JOURNAL ARTICLE
Jorge Sánchez-SanMartín, Sebastián L Márquez, Giannina Espina, Rodrigo Cortés-Antiquera, Junsong Sun, Jenny M Blamey
Laccases are industrially relevant enzymes that have gained great biotechnological importance. To date, most are of fungal and mesophilic origin; however, enzymes from extremophiles possess an even greater potential to withstand industrial conditions. In this study, we evaluate the potential of a recombinant spore-coat laccase from the thermoalkaliphilic bacterium Bacillus sp. FNT (FNTL) to biodegrade antibiotics from the tetracycline, β-lactams, and fluoroquinolone families. This extremozyme was previously characterized as being thermostable and highly active in a wide range of temperatures (20-90 °C) and very versatile towards several structurally different substrates, including recalcitrant environmental pollutants such as PAHs and synthetic dyes...
March 19, 2024: Biomolecules
#14
JOURNAL ARTICLE
Sarah M Mah, Mark Brown, Rachel C Colley, Laura C Rosella, Grant Schellenberg, Claudia Sanmartin
BACKGROUND: Small area estimation refers to statistical modelling procedures that leverage information or "borrow strength" from other sources or variables. This is done to enhance the reliability of estimates of characteristics or outcomes for areas that do not contain sufficient sample sizes to provide disaggregated estimates of adequate precision and reliability. There is growing interest in secondary research applications for small area estimates (SAEs). However, it is crucial to assess the analytic value of these estimates when used as proxies for individual-level characteristics or as distinct measures that offer insights at the area level...
March 20, 2024: Health Reports
#15
JOURNAL ARTICLE
Judit Algarra-Sahuquillo, Beatriz Llombart, Carlos Serra-Guillen, Onofre Sanmartin
No abstract text is available yet for this article.
March 22, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
#16
REVIEW
Marta Araujo-Castro, Paola Parra, Patricia Martín Rojas-Marcos, Miguel Paja Fano, Marga González Boillos, Eider Pascual-Corrales, Ana María García Cano, Jorge Gabriel Ruiz-Sanchez, Almudena Vicente Delgado, Emilia Gómez Hoyos, Rui Ferreira, Iñigo García Sanz, Mònica Recasens Sala, Rebeca Barahona San Millan, María José Picón César, Patricia Díaz Guardiola, Carolina M Perdomo, Laura Manjón-Miguélez, Rogelio García Centeno, Ángel Rebollo Román, Paola Gracia Gimeno, Cristina Robles Lázaro, Manuel Morales-Ruiz, María Calatayud, Simone Andree Furio Collao, Diego Meneses, Miguel Sampedro Nuñez, Verónica Escudero Quesada, Elena Mena Ribas, Alicia Sanmartín Sánchez, Cesar Gonzalvo Diaz, Cristina Lamas, María Del Castillo Tous, Joaquín Serrano Gotarredona, Theodora Michalopoulou Alevras, Eva María Moya Mateo, Felicia A Hanzu
PURPOSE: To compare the clinical and hormonal characteristics of patients with familial hyperaldosteronism (FH) and sporadic primary aldosteronism (PA). METHODS: A systematic review of the literature was performed for the identification of FH patients. The SPAIN-ALDO registry cohort of patients with no suspicion of FH was chosen as the comparator group (sporadic group). RESULTS: A total of 360 FH (246 FH type I, 73 type II, 29 type III, and 12 type IV) cases and 830 sporadic PA patients were included...
2024: Frontiers in Endocrinology
#17
JOURNAL ARTICLE
Nathalia Zini, Matheus Henrique Tavares Ávila, Natalia Morbi Cezarotti, Maisa Carla Pereira Parra, Cecília Artico Banho, Livia Sacchetto, Andreia Francesli Negri, Emerson Araújo, Cintia Bittar, Bruno Henrique Gonçalves de Aguiar Milhin, Victor Miranda Hernandes, Karina Rocha Dutra, Leonardo Agopian Trigo, Leonardo Cecílio da Rocha, Rafael Alves da Silva, Gislaine Celestino Dutra da Silva, Tamires Fernanda Pereira Dos Santos, Beatriz de Carvalho Marques, Andresa Lopes Dos Santos, Marcos Tayar Augusto, Natalia Franco Bueno Mistrão, Milene Rocha Ribeiro, Tauyne Menegaldo Pinheiro, Thayza Maria Izabel Lopes Dos Santos, Clarita Maria Secco Avilla, Victoria Bernardi, Caroline Freitas, Flora de Andrade Gandolfi, Hélio Correa Ferraz Júnior, Gabriela Camilotti Perim, Mirella Cezare Gomes, Pedro Henrique Carrilho Garcia, Rodrigo Sborghi Rocha, Tayna Manfrin Galvão, Eliane Aparecida Fávaro, Samuel Noah Scamardi, Karen Sanmartin Rogovski, Renan Luiz Peixoto, Luiza Benfatti, Leonardo Teixeira Cruz, Paula Patricia de Freitas Chama, Mânlio Tasso Oliveira, Aripuanã Sakurada Aranha Watanabe, Ana Carolina Bernardes Terzian, Alice de Freitas Versiani, Margareth Regina Dibo, Francisco Chiaravalotti-Neto, Scott Cameron Weaver, Cassia Fernanda Estofolete, Nikos Vasilakis, Mauricio Lacerda Nogueira
BACKGROUND: Chikungunya virus (CHIKV) has spread across Brazil with varying incidence rates depending on the affected areas. Due to cocirculation of arboviruses and overlapping disease symptoms, CHIKV infection may be underdiagnosed. To understand the lack of CHIKV epidemics in São José do Rio Preto (SJdRP), São Paulo (SP), Brazil, we evaluated viral circulation by investigating anti-CHIKV IgG seroconversion in a prospective study of asymptomatic individuals and detecting anti-CHIKV IgM in individuals suspected of dengue infection, as well as CHIKV presence in Aedes mosquitoes...
March 14, 2024: PLoS Neglected Tropical Diseases
#18
REVIEW
Eduardo Angulo-Elizari, Andreina Henriquez-Figuereo, Cristina Morán-Serradilla, Daniel Plano, Carmen Sanmartín
Cancer encompasses a group of pathologies with common characteristics, high incidence, and prevalence in all countries. Although there are treatments available for this disease, they are not always effective or safe, often failing to achieve the desired results. This is why it is necessary to continue the search for new therapies. One of the strategies for obtaining new antitumor drugs is the use of 1,4-naphthoquinone as a scaffold in synthetic or natural products with antitumor activity. This review focuses on compiling studies related to the antitumor activity of 1,4-naphthoquinone and its natural and synthetic derivatives over the last 10 years...
February 23, 2024: European Journal of Medicinal Chemistry
#19
JOURNAL ARTICLE
Juan Sanchis, Héctor Bueno, Sergio García-Blas, Oriol Alegre, David Martí, Manuel Martínez-Sellés, Laura Domínguez-Pérez, Pablo Díez-Villanueva, Jose A Barrabés, Francisco Marín, Adolfo Villa, Marcelo Sanmartín, Cinta Llibre, Alessandro Sionís, Antoni Carol, Agustín Fernández-Cisnal, Elena Calvo, María José Morales, Jaime Elízaga, Iván Gómez, Fernando Alfonso, Bruno García Del Blanco, Francesc Formiga, Eduardo Núñez, Julio Núñez, Albert Ariza-Solé
IMPORTANCE: The MOSCA-FRAIL randomized clinical trial compared invasive and conservative treatment strategies in patients with frailty with non-ST-segment elevation myocardial infarction (NSTEMI). It showed no differences in the number of days alive and out of the hospital at 1 year. OBJECTIVE: To assess the outcomes of the MOSCA-FRAIL trial during extended follow-up. DESIGN, SETTING, AND PARTICIPANTS: The MOSCA-FRAIL randomized clinical trial was conducted at 13 hospitals in Spain between July 7, 2017, and January 9, 2021, and included 167 adults (aged ≥70 years) with frailty (Clinical Frailty Scale score ≥4) and NSTEMI...
March 4, 2024: JAMA Network Open
#20
JOURNAL ARTICLE
Lucia Billeci, Chiara Sanmartin, Alessandro Tonacci, Isabella Taglieri, Giuseppe Ferroni, Roberto Marangoni, Francesca Venturi
BACKGROUND: Any action capable of creating expectations about product quality would be able to modulate experienced pleasantness. In this context, during the 2022 edition of the Internet Festival (Pisa, Italy) a 'social experiment' was promoted to set up an affordable and reliable methodology based on wearable sensors to measure the emotions aroused in a live context on consumers by different kinds of wines. Therefore, 5 wines (two faulty ones and three high quality samples) were proposed to 50 non-selected consumers in an arousing context with live jazz music as background...
March 5, 2024: Journal of the Science of Food and Agriculture
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