Ran Zhuo, Zimu Zhang, Yanling Chen, Gen Li, Shibei Du, Xinyi Guo, Randong Yang, Yanfang Tao, Xiaolu Li, Fang Fang, Yi Xie, Di Wu, Yang Yang, Chun Yang, Hongli Yin, Guanghui Qian, Hairong Wang, Juanjuan Yu, Siqi Jia, Frank Zhu, Chenxi Feng, Jianwei Wang, Yunyun Xu, Zhiheng Li, Lei Shi, Xiaodong Wang, Jian Pan, Jian Wang
Super enhancers (SEs) are genomic regions comprising multiple closely spaced enhancers, typically occupied by a high density of cell-type-specific master transcription factors (TFs) and frequently enriched in key oncogenes in various tumors, including neuroblastoma (NB), one of the most prevalent malignant solid tumors in children originating from the neural crest. Cyclin-dependent kinase 5 regulatory subunit-associated protein 3 (CDK5RAP3) is a newly identified super-enhancer-driven gene regulated by master TFs in NB; however, its function in NB remains unclear...
April 16, 2024: Cancer Letters