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https://www.readbyqxmd.com/read/28214042/erosive-pustular-dermatosis-of-the-scalp-clinical-trichoscopic-and-histopathologic-features-of-20-cases
#1
Michela Starace, Camilla Loi, Francesca Bruni, Aurora Alessandrini, Cosimo Misciali, Annalisa Patrizi, Bianca Maria Piraccini
BACKGROUND: Erosive pustular dermatosis of the scalp is a chronic eruption that leads to scarring alopecia. OBJECTIVE: The clinical, dermoscopic, and histopathological features and the course of the disease in 20 patients were reviewed and compared with the reports in the literature. METHODS: Gender, age at diagnosis, age at onset, duration, topography, predisposing factors, concomitant diseases, trichoscopy, histology, treatment, and outcome were taken into consideration...
February 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28205205/regression-of-cutaneous-xerosis-with-emollient-treatment-in-sub-saharan-african-patients
#2
Franck Boralevi, Alain-Patrice Meledie N'Djong, Pauline Yao Yoboue, Ousmane Faye, Mame Thierno Dieng, Sophie Coniquet, Félix Atadokpede, Pascal Antoine Niamba, Alain Delarue, Christine Cazeau
Emollients have proven effective in improving cutaneous xerosis in various populations; however, no clinical data are available for African patients. The observational study "Xerafrica" was conducted by dermatologists in seven sub-Saharan countries to assess the evolution of xerosis after an 8-week treatment with an emollient. Patients were children above 3 years or adults. Secondary objectives were to assess pruritus, improvement in symptoms, quality of life, satisfaction, and tolerance. An analysis of 185 patients was made...
February 16, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28196317/common-skin-conditions-in-children-noninfectious-rashes
#3
Brian Z Rayala, Dean S Morrell
Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Emollients and topical corticosteroids are first-line therapies. Topical calcineurin inhibitors are second-line, steroid-sparing drugs for certain conditions, such as face and eyelid eczema...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28194815/peristomal-psoriasis
#4
C Marshall, S Woodmansey, C C Lyon
BACKGROUND: Psoriasis is a common skin condition, affecting 1.3-2.2% of the population. The prevalence of psoriasis has previously been reported as 11.2% in patients with Crohn disease (CD) and 5.7% in patients with ulcerative colitis. AIM: To assess the prevalence of psoriasis around stoma sites and identify the most effective treatment. METHODS: A departmental database of all patients attendings stoma clinic was accessed between 1 May 2003 and 15 October 2015...
February 13, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28193616/assessing-the-effectiveness-of-topical-betamethasone-to-treat-chronic-chilblains-a-randomised-clinical-trial-in-primary-care
#5
Ibo H Souwer, Jacobus Hj Bor, Paul Smits, Antoine Lm Lagro-Janssen
BACKGROUND: GPs prescribe topical corticosteroids to patients with chronic chilblains despite poor evidence for their effectiveness. The authors of the current study therefore decided to assess the effectiveness of topical steroids in a primary care setting. AIM: To assess the effectiveness of topical application of betamethasone valerate 0.1% cream in patients with chronic chilblains. DESIGN AND SETTING: A placebo-controlled, double-blind, crossover, randomised clinical trial in a Dutch primary care setting...
February 13, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28192821/-eosinophilic-esophagitis-update-pathogenesis-diagnosis-and-therapy
#6
Ulrike von Arnim, S Miehlke, A Madisch, M Vieth, A Straumann, P Malfertheiner
Eosinophilic esophagitis (EoE) is a clinicopathological condition of the esophagus that has become increasingly recognised over the last decade. EoE represents a chronic immune-mediated inflammatory disease of the esophagus. In adults dysphagia is the predominant symptom. Upper gastrointestinal endoscopy is required in order to take biopsies from the esophagus. The diagnose is confirmed histologically by typical eosinophilic infiltration of the esophagus mucosa. Until now there is no approved therapy world-wide although we know that topic and systemic steroids are highly effective in EoE...
January 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28188242/diagnosis-of-endocrine-disease-steroid-hormone-analysis-in-diagnosis-and-treatment-of-dsd-position-paper-of-eu-cost-action-bm-1303-dsdnet
#7
Alexandra Kulle, Nils Krone, Paul-Martin Holterhus, Gerhard Schuler, Ronda Greaves, Anders Juul, Yolanda de Rijke, Michaela Hartmann, Alessandro Saba, Olaf Hiort, Stefan Wudy
Disorders or differences in sex development (DSD) comprise a heterogeneous group of conditions with an atypical sex development. For optimal diagnosis highly specialized laboratory analyses are required across European countries. Working group 3 of EU COST (European Cooperation in Science and Technology) Action BM 1303 "DSDnet" "Harmonisation of Laboratory Assessment" has developed recommendations on laboratory assessment for DSD regarding the use of technologies and analytes to be investigated. This position paper on steroid hormone analysis in diagnosis and treatment of DSD was compiled by a group of specialists in DSD and/or hormonal analysis, either from participating European Countries or international partner countries...
February 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28185668/effect-of-nebulized-budesonide-on-decreasing-the-recurrence-of-allergic-fungal-rhinosinusitis
#8
Qi Dai, Chen Duan, Quan Liu, Hongmeng Yu
OBJECTIVE: The aim of this study was to evaluate the clinical efficacy and the effects on decreasing the recurrence of AFRS (allergic fungal rhinosinusitis) of a budesonide inhalation suspension delivered via transnasal nebulization to patients following endoscopic sinus surgery. SUBJECTS AND METHODS: Thirty-five patients were recruited into this study. Final diagnoses were reached using Bent and Kuhn's criteria. The eligible patients were randomly divided into two groups: the budesonide transnasal nebulization group (group A) and the topical nasal steroids group (group B)...
February 1, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28182252/determining-effects-of-superfine-sheep-wool-in-infantile-eczema-dessine-a-randomized-paediatric-cross-over-study
#9
J C Su, R Dailey, M Zallmann, E Leins, L Taresch, S Donath, S S Heah, A J Lowe
INTRODUCTION: Despite limited evidence, woollen clothing has traditionally been considered to be an irritant that should be avoided by individuals with atopic dermatitis (AD). Wool fibres come in a range of diameters, and have beneficial thermodynamic and moisture transport properties. This study examines the effects of superfine merino wool on symptoms in participants with mild-moderate AD. METHODS: The trial was a 12-week randomized assessor-blinded cross-over prospective cohort study of 39 patients aged 4 weeks to 3 years with mild-moderate AD, comparing superfine merino wool ensembles with standard cotton clothing chosen by parents...
February 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28182149/anterior-segment-ischemia-after-strabismus-surgery
#10
Emine Seyhan Göçmen, Yonca Atalay, Özlem Evren Kemer, Hikmet Yavuz Sarıkatipoğlu
A 46-year-old male patient was referred to our clinic with complaints of diplopia and esotropia in his right eye that developed after a car accident. The patient had right esotropia in primary position and abduction of the right eye was totally limited. Primary deviation was over 40 prism diopters at near and distance. The patient was diagnosed with sixth nerve palsy and 18 months after trauma, he underwent right medial rectus muscle recession. Ten months after the first operation, full-thickness tendon transposition of the superior and inferior rectus muscles (with Foster suture) was performed...
January 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28178053/posterior-fourchette-fissure-resolution-after-injection-of-autologous-adipose-derived-regenerative-cells
#11
Katarina Andjelkov, Zoran Maricic
BACKGROUND: Posterior fourchette fissures can recur and become chronic despite multiple medical and surgical treatments. We report the case of a recurrent posterior fourchette fissure that resolved after subdermal injection with adipose-derived regenerative cells. CASE: A 44-year-old primiparous patient experienced severe dyspareunia for 10 years as a result of a recurrent posterior fourchette fissure that began after a vaginal delivery with episiotomy. She was treated unsuccessfully with topical antibiotics, estrogen, and steroids and ultimately with a perineoplasty at the age of 42 years...
February 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28170093/topical-treatments-for-blepharokeratoconjunctivitis-in-children
#12
REVIEW
Michael O'Gallagher, Catey Bunce, Melanie Hingorani, Frank Larkin, Stephen Tuft, Annegret Dahlmann-Noor
BACKGROUND: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia.Treatment of BKC is directed towards modification of meibomian gland disease and the bacterial flora of lid margin and conjunctiva, and control of ocular surface inflammation...
February 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28168623/a-report-of-two-cases-of-solid-facial-edema-in-acne
#13
Sarah Kuhn-Régnier, Joanna Mangana, Katrin Kerl, Jivko Kamarachev, Lars E French, Antonio Cozzio, Alexander A Navarini
INTRODUCTION: Solid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published. METHODS: We report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids. RESULTS: Both cases responded to oral isotretinoin, in one case combined with oral steroids...
February 6, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28165606/effect-of-topical-antiinflammatory-drugs-on-mechanical-behavior-of-rabbit-cornea
#14
Domenico Lepore, Roberto De Santis, Monica M Pagliara, Antonio Gloria, Olimpia Oliviero, Carlo Nucci, Giovanni Improta, Maria Triassi, Luigi Ambrosio
BACKGROUND: A variety of antiinflammatory therapies are employed to promote corneal wound healing. The effects of steroidal and nonsteroidal antiinflammatory drugs on the biomechanical properties of rabbit cornea were investigated over time using tensile tests. METHODS: Full-thickness incisions were made and used to analyze the effects of dexamethasone sodium phosphate 0.1% and diclofenac sodium 0.1% on corneal biomechanical properties during wound healing at 7, 14 and 21 days after surgery...
February 4, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28161929/presumed-sterile-endophthalmitis-afer-intravitreal-triamcinolone-kenalog-more-common-and-less-benign-than-we-thought
#15
Angie H C Fong, Carmen K M Chan
PURPOSE: This study aimed to review the incidence and clinical outcome of presumed sterile endophthalmitis after the off-label use of intravitreal Kenalog injections (triamcinolone acetonide with 1.5% benzyl alcohol) and to compare it with the presumed sterile endophthalmitis incidence after intravitreal Kenacort-A (0.99% benzyl alcohol) at our center. DESIGN: This was a single-center, retrospective, consecutive, interventional case series of all patients who underwent intravitreal Kenalog injections at Hong Kong Eye Hospital from November 1, 2009, to July 31, 2012...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28161837/autologous-platelet-rich-plasma-prp-in-chronic-penile-lichen-sclerosus-the-impact-on-tissue-repair-and-patient-quality-of-life
#16
Francesco Casabona, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, Ilaria Baldelli
PURPOSE: Lichen sclerosus (LS) is a chronic inflammatory skin condition that frequently involves the anogenital region. Ongoing research is focused on finding more effective treatments for tissue repair and reducing symptoms. The aim of this study is to evaluate the effectiveness of platelet-rich plasma (PRP) local injections in penile LS. METHODS: Forty-five male patients affected by penile LS underwent injections of autologous PRP in the affected skin areas. Age at diagnosis and at first treatment, number of treatments, clinical conditions (phimosis, splitting, inflammation, synechiae, meatus stenosis), symptoms (pain, burning, itching), and functional impairment were considered...
February 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28156498/prevention-of-everolimus-exemestane-eve-exe-stomatitis-in-postmenopausal-pm-women-with-hormone-receptor-positive-hr-metastatic-breast-cancer-mbc-using-a-dexamethasone-based-mouthwash-mw-results-of-the-swish-trial
#17
J Thaddeus Beck, John A Glaspy, Julio Antonio Peguero, Timothy J Pluard, Navneet Dhillon, Leon C Hwang, Chaitali Singh Nangia, Ingrid A Mayer, Timothy F Meiller, Mark Steven Chambers, Ghulam Warsi, Robert William Sweetman, J Randy Sabo, Lasikas Seneviratne
: 189 Background: Stomatitis is a frequent adverse event (AE) associated with mTOR inhibition. In BOLERO-2 patients (pts) receiving EVE/EXE, all grade (Gr) stomatitis was 67%; 33% had Gr ≥ 2 and 8% Gr 3. Median time to ≥ Gr 2 onset was 15.5 days; incidence of new stomatitis (Gr ≥ 2) plateaued at 6 wks. In a meta-analysis, 89% of first stomatitis events occurred within 8 wks. Topical steroids are used to treat aphthous ulcers; anecdotal use as prophylaxis has been reported. METHODS: Eligibility included PM women with HR+ MBC prescribed EVE/EXE...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28151873/bimatoprost-induced-late-onset-choroidal-detachment-after-trabeculectomy-a-case-report-and-review-of-the-literature
#18
Shunsuke Nakakura, Asuka Noguchi, Hitoshi Tabuchi, Yoshiaki Kiuchi
BACKGROUND: Choroidal detachment (CD) is often observed at an early period particularly after trabeculectomy and glaucoma drainage implant surgery. However, topical antiglaucoma eye drop-induced CD is a rare complication. Here, we report a case of topical bimatoprost-induced late-onset CD after trabeculectomy and review the literature. CASE REPORT: A 74-year-old man who suffered from primary open-angle glaucoma underwent his initial trabeculectomy with mitomycin-C in the right eye...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28151588/safety-of-long-term-intranasal-budesonide-delivered-via-the-mucosal-atomization-device-for-chronic-rhinosinusitis
#19
Jamil Manji, Gurkaran Singh, Christopher Okpaleke, Anali Dadgostar, Fahad Al-Asousi, Ameen Amanian, Luis Macias-Valle, Andres Finkelstein, Mark Tacey, Andrew Thamboo, Amin Javer
BACKGROUND: Although short-term use (≤2 months) of atomized topical nasal steroids has been shown to be safe and effective, the long-term safety has yet to be demonstrated. The aim of this study was to determine the impact of long-term topical budesonide treatment via the mucosal atomization device (MAD) on the hypothalamic-pituitary-adrenal axis (HPAA) and intraocular pressure (IOP). METHODS: A cross-sectional study of patients with chronic rhinosinusitis (CRS), with or without nasal polyposis, managed with daily nasal budesonide via MAD was conducted at a tertiary rhinology center...
February 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28150904/rationally-developed-organic-salts-of-tolfenamic-acid-and-its-%C3%AE-alanine-derivatives-for-dual-purpose-anti-inflammatory-topical-gel-and-anti-cancer-agent
#20
Parthasarathi Dastidar, Rumana Parveen, Bommagani Sravanthi
A new series of primary ammonium monocarboxylate (PAM) salts of a non-steroidal-anti-Inflammatory-drug (NSAID) namely Tolfenamic acid (TA) and its β-alanine derivative was generated; nearly 67% of the salts in the series showed gelling ability with various solvents including water (biogenic solvent) and methyl salicylate (typically used for topical gel formulations). Gels were characterized by table top and dynamic rheology, electron microscopy etc. Structure-property correlation based on single crystal and powder X-ray diffraction data of several gelator and non-gelator salts revealed intriguing insights...
February 2, 2017: Chemistry, An Asian Journal
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