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https://www.readbyqxmd.com/read/29667726/interventions-for-infantile-haemangiomas-of-the-skin
#1
REVIEW
Monica Novoa, Eulalia Baselga, Sandra Beltran, Lucia Giraldo, Ali Shahbaz, Hector Pardo-Hernandez, Ingrid Arevalo-Rodriguez
BACKGROUND: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. This is an update of a Cochrane Review first published in 2011...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29661689/cardiometabolic-risk-and-female-sexuality-part-ii-understanding-and-overcoming-gender-differences-the-key-role-of-an-adequate-methodological-approach
#2
REVIEW
Elisa Maseroli, Irene Scavello, Linda Vignozzi
INTRODUCTION: Although basic science and clinical research indicate that the vascular physiopathology of male and female sexual dysfunction (FSD) is similar, to date the association between FSD and cardiovascular (CV) diseases has been only marginally explored. AIM: To discuss the potential reasons for differences in the role of CV diseases and risk factors in sexual function in women vs men in the 2nd part of a 2-part review. METHODS: A thorough literature search of peer-reviewed publications on the topic was performed using the PubMed database...
April 13, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29657976/efficacy-of-additional-topical-betamethasone-in-persistent-cystoid-macular-oedema-after-carbonic-anhydrase-inhibitor-treatments-in-retinitis-pigmentosa
#3
Shohei Kitahata, Yasuhiko Hirami, Seiji Takagi, Cody Kime, Masashi Fujihara, Yasuo Kurimoto, Masayo Takahashi
Objective: We investigated the efficacy of additional topical betamethasone in persistent cystoid macular oedema (CMO) after carbonic anhydrase inhibitors (CAIs) therapy. Methods and analysis: This retrospective cohort study included 16 eyes of 10 patients with retinitis pigmentosa (RP). All patients were previously administered CAI for at least 3 months to treat CMO secondary to RP and lacking an effective reduction (≥11%) of central foveal thickness (CFT)...
2018: BMJ Open Ophthalmology
https://www.readbyqxmd.com/read/29656404/pyoderma-gangrenosum-in-an-infant-a-case-report-and-review-of-the-literature
#4
Lauren Crouse, Diana McShane, Dean S Morrell, Eveline Y Wu
Pyoderma gangrenosum is a neutrophilic dermatosis that is rare in infancy, with only 20 cases reported in the literature. We present a case of infantile pyoderma gangrenosum refractory to topical steroids, tacrolimus, and dapsone as well as systemic steroids and infliximab that is currently well controlled with the addition of oral tacrolimus. To our knowledge, this is the first report of the effective, safe use of oral tacrolimus in combination with infliximab for infantile pyoderma gangrenosum. We review all current cases of infantile pyoderma gangrenosum, as well as tacrolimus and its role in the treatment of this condition...
April 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29652210/idiopathic-central-nervous-system-inflammatory-disease-in-the-setting-of-hla-b27-uveitis
#5
Eric L Crowell, Margaret L Pfeiffer, Ankur A Kamdar, Mary K Koenig, Susan E Wittenberg, Emilio P Supsupin, Ore-Ofe O Adesina
PURPOSE: The purpose of the article is to describe a novel case of idiopathic central nervous system inflammatory disease with bilateral human leukocyte antigen (HLA)-B27-positive anterior uveitis. METHODS/RESULTS: A 15-year-old African American boy with bilateral HLA-B27-positive anterior uveitis controlled with topical and oral steroids for 8 months acutely developed headaches, left eyelid ptosis, and binocular diplopia. Imaging showed lesions in the right midbrain, superior colliculus, cerebellar peduncles, and cerebellar vermis and leptomeningeal enhancement along the vermian foliae...
April 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29645316/neuropeptide-and-steroid-hormone-mediators-of-neuroendocrine-regulation
#6
REVIEW
Ashley L Heck, Carlos C Crestani, Alonso Fernández-Guasti, Darwin O Larco, Artur Mayerhofer, Charles E Roselli
In order to maintain the health and wellbeing of all mammals, numerous aspects of physiology are controlled by neuroendocrine mechanisms. These mechanisms ultimately enable communication between neurons and glands throughout the body and are centrally mediated by neuropeptides and/or steroid hormones. A recent session at the International Workshop in Neuroendocrinology highlighted essential roles for some of these neuropeptide and steroid hormone mediators in the neuroendocrine regulation of stress-, reproduction-, and behavior- related processes...
April 12, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29630157/an-intensely-pruritic-pebbled-presentation
#7
Livia Francine Soriano, Conn McGrath, Mark Hawthorne, Arucha Linda Ekeowa-Anderson
Lichen amyloidosis (LA) is a form of primary localized cutaneous amyloidosis (PLCA) characterized by bilateral intensely itchy domed scaly hyperkeratotic papules. Lichen amyloidosis is rare and affects men more than women. It is uncommonly seen in the western world but more prevalent in Asia. These papules most typically affect the shins and occasionally the arms and torso. Lichen amyloidosis has been reported in association with autoimmune disorders and after prolonged exfoliation and friction of affected skin...
March 7, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29623252/intraocular-inflammation-in-a-case-of-bee-sting-injury
#8
Ekta Rishi, Pukhraj Rishi
A19-year-old man presented with decreased vision in the right eye following a bee sting injury, ten days back. Examination revealed conjunctival hyperemia at the site of the sting, anterior uveitis, vitritis, mild disc hyperemia, ocular hypotony, and striae at macula. Treatment was initiated elsewhere with topical antibiotics, steroid, and cycloplegic. Systemic steroids were added. Three weeks later, vitiritis resolved, intraocular pressure became normal and the vision improved from 20/60 to 20/20. However, a chorioretinal atrophy in the vicinity of the sting site was noted...
2018: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/29622703/immune-stromal-keratitis-a-rare-ocular-presentation-of-tuberculosis
#9
Deepali Singhal, Prafulla Kumar Maharana, Namrata Sharma, Jeewan S Titiyal
An 11-year-old female patient presented with diminution of vision in both the eyes for the last 4 days. She had redness, watering and photophobia for the past 11 days. Slit lamp examination revealed multiple disc-shaped corneal stromal infiltrates with an overlying epithelial defect and hypopyon in both the eyes. A provisional diagnosis of infective keratitis was made. The patient was started on empirical antimicrobial therapy. However, no improvement was noted over the next 72 hours. Microbiological examination of the corneal scraping from both the eyes was negative...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29619848/biological-treatment-for-psoriasis-and-the-risk-of-herpes-zoster-results-from-the-psoriasis-longitudinal-assessment-and-registry-psolar
#10
Guy Shalom, Luigi Naldi, Mark Lebwohl, Arjen Nikkels, Elke M G J de Jong, Steven Fakharzadeh, Kavitha G Goyal, Bhaskar Srivastava, Wayne Langholff, Claudia Galindo, Arnon D Cohen
PURPOSE: To describe the risk of herpes zoster (HZ) in patients with psoriasis and its relation to non-biologic systemic therapies or biologic treatment. MATERIALS AND METHODS: Psoriasis Longitudinal Assessment and Registry (PSOLAR) is an international, prospective, registry that follows adult patients with psoriasis eligible to receive non-biologic systemic therapies or biologic therapies. Mutually exclusive therapy cohorts were defined. HZ incident rates were calculated for each therapy cohort and rates between cohorts were compared using hazard ratios (HR) adjusted for potential confounders, in new users and prevalent-exposure patients...
April 5, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29618940/langerhans-cell-histiocytosis-with-hemorrhagic-uveitis-and-exudative-retinal-detachment
#11
Ranju Kharel Sitaula, Anadi Khatri
Bilateral intraocular involvement in Langerhans cell histiocytosis (LCH) is uncommon. A 15-year-old boy presented with painless decreased vision in right and painful left red eye of 2 weeks duration. Visual acuity was 20/500 and 20/200, respectively. A fixed dilated pupil with exudative retinal detachment was present in the right eye and hemorrhagic iris nodules with hyphema and hypopyon were seen in the left eye. Intraocular pressure was 12 and 31 mmHg, respectively, in each eye. Ocular symptoms were preceded by fever with multiple skin rashes, subcutaneous nodules, and lymph node enlargement...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29611499/case-report-paederus-dermatitis-in-the-returning-traveler
#12
Jacob W Pierce, Barry Rittman, Jillian E Raybould
Rash in the returned traveler can provide a diagnostic dilemma for clinicians, but a detailed history including epidemiologic exposures can allow prompt diagnosis of etiologies uncommon in the United States. One such disease is Paederus dermatitis, an irritant contact dermatitis related to exposure to the rove beetle characterized by bullous lesions with surrounding erythema. Although cases and outbreaks have commonly been reported throughout the world, they are rarely reported in travelers returning to the United States...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29610773/are-they-high-on-steroids-tailored-interventions-help-improve-screening-for-steroid-induced-hyperglycaemia-in-hospitalised-patients
#13
Punith Kempegowda, Alana C Livesey, Laura McFarlane-Majeed, Joht Singh Chandan, Theresa Smyth, Martha Stewart, Karen Blackwood, Michelle McMahon, Anitha Vijayan Melapatte, Sofia Salahuddin, Jonathan Webber, Sandip Ghosh
Steroid-induced hyperglycaemia (SIH) is a common adverse effect in patients both with and without diabetes. This project aimed to improve the screening and diagnosis of SIH by improving the knowledge of healthcare professionals who contribute to the management of SIH in hospitalised patients. Monitoring and diagnosis of SIH were measured in areas of high steroid use in our hospital from May 2016 to January 2017. Several interventions were implemented to improve knowledge and screening for SIH including a staff education programme for nurses, healthcare assistants and doctors...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29606120/angiolymphoid-hyperplasia-with-eosinophilia-a-case-report
#14
Alexey Youssef, Ali Ramez Hasan, Youssef Youssef, Lina Al-Soufi, Yahya Elshimali, Zuheir Alshehabi
BACKGROUND: Angiolymphoid hyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. CASE PRESENTATION: In this case, we report a 13-year-old Caucasian girl with bilateral, huge, protruding, and yellowish nostril masses which were peculiar in location and of gross appearance...
April 2, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29602601/dioscorea-zingiberensis-c-h-wright-an-overview-on-its-traditional-use-phytochemistry-pharmacology-clinical-applications-quality-control-and-toxicity
#15
REVIEW
Xinxin Zhang, Ming Jin, Nigatu Tadesse, Jun Dang, Tao Zhou, Hui Zhang, Sicen Wang, Zengjun Guo, Yoichiro Ito
ETHNOPHARMACOLOGICAL RELEVANCE: Dioscorea zingiberensis C. H. Wright (D. zingiberensis), Dioscoreaceae, is used extensively in traditional Chinese medicines. The aim of the current review paper is to give a comprehensive overview of the traditional usage and phytochemistry of the plant. Clinical studies performed and products prepared from the plant and active principles will be mentioned. In addition a review of the taxonomy of the genus Dioscorea is given. MATERIALS AND METHODS: A systematic search on literature has been performed in databases like Google Scholar, Science Direct, Scifinder, Web of Science, and in Chinese databases (China Knowledge Resource Integrated, i...
March 28, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29594973/clinical-and-therapeutic-aspects-of-linear-psoriasis-a-study-of-30-cases
#16
Matthieu Say, Franck Boralévi, Cédric Lenormand, Anne-Claire Bursztejn, Eric Estève, Alice Phan, Emmanuelle Bourrat, Jean-Philippe Lacour, Marie-Aleth Richard, Aurélie Acher, Denis Jullien, Nathalie Beneton, Vincent Descamps, Christine Bodemer, Marion Lagaude, Christine Chiaverini, Emmanuel Mahé
BACKGROUND: Psoriasis affects 2-4% of the population, with the most common clinical type being plaque psoriasis. The linear form of psoriasis is very rare. The literature on linear psoriasis (LP) consists of only case reports, and data are few. OBJECTIVE: This study aimed to better understand LP in a large-scale study. PATIENTS AND METHODS: We retrospectively retrieved the medical records from 14 French medical centers of patients newly diagnosed clinically with LP, with or without the support of histology, between 1 February and 31 July 2015...
March 29, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29593377/management-of-chronic-ocular-sarcoidosis-challenges-and-solutions
#17
REVIEW
Artemis Matsou, Konstantinos T Tsaousis
Background: Sarcoidosis constitutes one of the leading causes of ocular inflammation. Chronic ocular sarcoidosis can affect any segment of the eye and its adnexa, producing a wide range of clinical manifestations and severity. If left untreated, permanent visual impairment or even blindness may ensue. Treatment approaches vary from topical therapy to systemic agents that induce immunosuppression to different levels according to disease severity. Objective: To review the published literature on the management options for chronic ocular sarcoidosis and provide a comprehensive list of available treatment strategies, including the newer biologics...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29588822/candida-albicans-endophthalmitis-following-penetrating-keratoplasty-a-case-report
#18
Shahram Bamdad, Aidin Meshksar, Mohammad Mostafa Safarpour
Endophthalmitis is one of the most serious complications of intraocular surgeries, and Candida albicans constitutes the majority of cases of post penetrating keratoplasty (PK) endophthalmitis. The presenting case is a 21-year-old woman with known case of advanced keratoconus and vernal keratoconjunctivitis who underwent PK, and developed recalcitrant anterior uveitis and subsequent whitish lesion on the superonasal of the lens. She was on topical steroids with possible impression of Uretts Zavalia syndrome versus phacoantigenic uveitis following traumatic cataract up to the 50th day of post operation that manifested symptoms of frank endophthalmitis; and underwent deep vitrectomy, lensectomy, localized iridectomy and irrigation with diluted Imipenem and Amphotericin-B...
January 2018: Electronic Physician
https://www.readbyqxmd.com/read/29587518/prospective-controlled-trial-for-the-treatment-of-acne-keloidalis-nuchae-with-a-long-pulsed-neodymium-doped-yttrium-aluminum-garnet-laser
#19
Denise K Woo, German Treyger, Marsha Henderson, Richard H Huggins, Diane Jackson-Richards, Iltefat Hamzavi
BACKGROUND: Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis with limited interventions of both high efficacy and low morbidity. OBJECTIVE: To assess the efficacy of the long-pulsed 1064-nm neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser and topical steroids as a treatment for AKN compared to topical steroids alone. METHODS: We conducted a single-blinded, randomised, within-patient right-left controlled trial (n = 13)...
March 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29587260/verbascoside-alleviates-atopic-dermatitis-like-symptoms-in-mice-via-its-potent-anti-inflammatory-effect
#20
Yongxi Li, Haiyang Yu, Yan Jin, Min Li, Caijie Qu
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interplay between multiple genetic and environmental factors. The pathogenesis of AD remains incompletely understood. Treatment with topical steroids for chronic AD symptoms has severe side effects and so a new treatment is required. Verbascoside is a hydrophilic phenylethanoid glycoside with antioxidant, anti-inflammatory properties. METHODS: Verbascoside was evaluated in AD-like lesions induced by the repetitive and alternative application of 2,4-dinitrochlorobenzene (DNCB) in BALB/c mice...
March 27, 2018: International Archives of Allergy and Immunology
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