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https://www.readbyqxmd.com/read/29904830/migraine-and-cerebrovascular-disease-still-a-dangerous-connection
#1
Elio Clemente Agostoni, Marco Longoni
Migraine is a common type of headache in young adults, with an estimated prevalence of 4% before puberty and as high as 25% in women by their mid to late 30s. About one third of migraineurs experience transient neurological symptoms known as auras, which characterize a variant known as migraine with aura. Many evidences have shown an increased risk of vascular events in patients affected by migraine, particularly among women and among migraine patients with aura. Potential underlying mechanisms include endothelial dysfunction, hypercoagulability, platelet aggregation, vasospasm, cardiovascular risk factors, paradoxical embolism, spreading depolarization, shared genetic risk, use of non-steroidal anti-inflammatory drugs, and immobilization...
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29902648/maintenance-treatment-of-eosinophilic-esophagitis-with-swallowed-topical-steroids-alters-disease-course-over-a-5-year-follow-up-period-in-adult-patients
#2
Thomas Greuter, Ekaterina Safroneeva, Christian Bussmann, Luc Biedermann, Stephan R Vavricka, David A Katzka, Alain M Schoepfer, Alex Straumann
BACKGROUND & AIMS: Although swallowed topical corticosteroids (STCs) are effective in inducing remission of active eosinophilic esophagitis (EoE), there are few data on maintenance of long-term remission. We evaluated the long-term effectiveness of STC therapy for adults with EoE. METHODS: We performed a retrospective study using the Swiss EoE database. We analyzed data on 229 patients with EoE treated with STCs (175 male; mean age at diagnosis, 39±15 years; median time until diagnosis, 6 years) from 2000 through 2014...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29892141/delayed-complications-and-long-term-management-of-sulfur-mustard-poisoning-a-narrative-review-of-recent-advances-by-iranian-researchers-part-%C3%B0-%C3%B0-clinical-management-and-therapy
#3
REVIEW
Leila Etemad, Mohammad Moshiri, Mahdi Balali-Mood
The present study aimed to review and discuss the recommended and recently suggested protocols by Iranian researchers for a long-term treatment of delayed complications of sulfur mustard (DCSM) in veterans. As indicated clinically, patients who suffer from delayed ocular complications of sulfur mustard (DOCS) benefit from treatments for dry eyes, therapeutic contact lenses, amniotic membrane transplantation; blepharorrhaphy, tarsorrhaphy, limbal stem cell transplantation; corneal transplantation, topical steroids, and immunosuppressive...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29891159/late-onset-refractive-shift-after-small-aperture-corneal-inlay-implantation
#4
Alfredo Amigó, Paula Martinez-Sorribes, Margarita Recuerda
We present a series of 5 consecutive cases in which a small-aperture corneal inlay (Kamra ACI7000PDT) was uneventfully implanted in a corneal pocket created at a depth between 200 μm and 250 μm. Three months after surgery, all patients had good visual results, normal corneal surfaces, and adequate stromal healing. Between 6 months and 19 months after surgery, visually significant refractive changes appeared in the form of a hyperopic shift in 4 cases and a myopic shift in 1 case. Topical steroids were ineffective...
May 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29886559/novel-therapy-for-male-hypogonadism
#5
REVIEW
Robert Carrasquillo, Kevin Chu, Ranjith Ramasamy
PURPOSE OF REVIEW: Hypogonadism and the treatment of low testosterone is increasingly a subject of medical inquiry and controversy. The few treatments that are FDA-approved such as testosterone topicals, injections, and pellets create significant demand from patients for treatments with more convenient means of administration, fewer adverse effects, and the ability to maintain male fertility. Off-label drugs are in abundant use for low testosterone, including selective estrogen receptor modulators, gonadotropins, and aromatase inhibitors...
June 9, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29885775/atypical-presentation-of-diffuse-lamellar-keratitis-after-small-incision-lenticule-extraction-sterile-multifocal-inflammatory-keratitis
#6
Alastair Stuart, Dan Z Reinstein, Ryan S Vida, Timothy J Archer, Glenn Carp
We describe a case of atypical diffuse lamellar keratitis (DLK) following small-incision lenticule extraction (SMILE). The patient presented with multiple focal white infiltrates 1 day after routine small-incision lenticule extraction surgery. An interface washout was performed, and the patient was managed with intensive topical steroids. Potential infectious keratitis was also investigated (by culture and Gram stain) and treated aggressively with steroids and antibiotics. The cultures were all negative with no growth, and the focal infiltrates gradually resolved, with no relapses at the 15-month postoperative follow-up and a faint 0...
June 6, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29885539/intravenous-immunoglobulins-as-a-new-opportunity-to-treat-discoid-lupus-erythematosus-a-case-report-and-review-of-the-literature
#7
REVIEW
Sara Tenti, Marta Fabbroni, Virginia Mancini, Filomena Russo, Mauro Galeazzi, Antonella Fioravanti
Discoid lupus erythematosus (DLE) is a chronic dermatological disease that can lead to scarring, alopecia and dyspigmentation, if not properly treated. Actually, no drugs are specifically approved for the treatment of CLE, although the first-line therapy usually consists of photoprotection associated to topical or oral steroids, topical calcineurin inhibitors and hydroxychloroquine (HCQ). In cases of DLE refractory to these medications, many other agents have been employed, such as dapsone, methotrexate, azathioprine, cyclophosphamide, biologic drugs and Intravenous Immunoglobulin (IVIG)...
June 6, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29884087/the-importance-of-topical-steroids-after-adhesiolysis-in-erosive-lichen-planus-and-graft-versus-host-disease
#8
S Rajkumar, F Lewis, R Nath
The aim of this study was to assess the efficacy of a postoperative steroid regimen in maintaining vulvovaginal architecture and vaginal patency following surgical adhesiolysis in severe erosive lichen planus (ELP) and genital graft versus host disease (GVHD). Sixteen women applied potent topical steroids to the vulva and vagina from 48 hours after surgery. Sexual and urinary function and vulvovaginal anatomy were assessed at 6 weeks, 6, 12 and 24 months. All of the patients had failed sexual function due to vaginal stenosis...
June 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29876624/eosinophilic-esophagitis-an-underdiagnosed-cause-of-dysphagia-and-food-impaction-to-be-recognized-by-otolaryngologists
#9
REVIEW
C Górriz Gil, V Matallana Royo, Ó Álvarez Montero, A Rodríguez Valiente, C Fernández Manzano, B Conde García, J R García-Berrocal
Eosinophilic esophagitis (EoE) is a recently recognised pathologic entity whose prevalence has risen significantly since first being described in 1993. Defined as a chronic, local immune-mediated disease with predominant eosinophil infiltration, it is nowadays the leading cause of dysphagia and food bolus impaction in children and young adults. Genetic and environmental risk factors, and especially food antigens, trigger the disease and are in the focus of investigation as avoidance can cure three quarters of patients...
June 6, 2018: HNO
https://www.readbyqxmd.com/read/29875865/evaluation-of-combined-topical-ozone-and-steroid-therapy-in-management-of-oral-lichen-planus
#10
Basma Mostafa, Mai Zakaria
AIM: The present study aims to assess the therapeutic effect of the combination of topical ozone and steroid therapy in comparison to topical ozone alone versus topical steroid as a control in the management of atrophic - erosive oral lichen planus (OLP). METHODS: Sixty-six patients are having atrophic-erosive OLP were included in the study. They were randomly divided into three equal groups to be treated with topical corticosteroids alone (steroid group) as control, topical ozone alone (ozone group) or combination of topical steroids and ozone (combined group)...
May 20, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29864953/plant-derived-anticancer-agents-a-green-approach-towards-skin-cancers
#11
REVIEW
Shakeel Ijaz, Naveed Akhtar, Muhammad Shoaib Khan, Abdul Hameed, Muhammad Irfan, Muhammad Adeel Arshad, Sajid Ali, Muhammad Asrar
Plants have been used as medicinal agents since the origin of mankind. High cost and severe side effects associated with conventional chemotherapy has limited their general acceptability and fuel up the search for alternate options. The alternative treatment options like phytochemicals have come up with ease of availability and cost effectiveness. Owing to their general acceptance, safety, low side effects and multistep targeting in signal transduction pathways, plant derived phyto-constituents have promising anti-carcinogenic potential for skin related cancers...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29863219/practice-pattern-variation-in-pediatric-eosinophilic-esophagitis-in-the-carolinas-eoe-collaborative-a-research-model-in-community-and-academic-practices
#12
Kevin Z Huang, Elizabeth T Jensen, Hannah X Chen, Lisa E Landes, Kristen A McConnell, M Angie Almond, Douglas T Johnston, Raquel Durban, Laura Jobe, Carrie Frost, Sarah Donnelly, Brady Antonio, Anca M Safta, J Antonio Quiros, Jonathan E Markowitz, Evan S Dellon
OBJECTIVES: Differences in the initial management of pediatric eosinophilic esophagitis (EoE) by practice setting have not been well characterized. We aimed to characterize these differences for sites in the Carolinas EoE Collaborative (CEoEC), a multicenter network of academic and community practices. METHODS: We performed a retrospective cohort study of pediatric EoE patients at five CEoEC sites: University of North Carolina (UNC) Hospital, Charlotte Asthma and Allergy Specialists, Greenville Health Systems, Wake Forest Baptist Medical Center, and the Medical University of South Carolina Hospital...
June 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29861637/majocchi-s-granuloma-current-perspectives
#13
REVIEW
Hazal Boral, Murat Durdu, Macit Ilkit
Majocchi's granuloma (MG) is a rare fungal infection of the dermis that is mainly caused by dermatophytes (in ≥95% of cases); the most frequently identified cause is anthropophilic Trichophyton rubrum . In the rest of the cases, the causes are non-dermatophytic fungi such as Aspergillus species. This review aimed to provide information about the current perspectives on MG regarding its clinical characteristics, predisposing factors, laboratory diagnosis, and treatment strategies. Although the lower extremities were reported to be the most common site of infection, facial involvement has been predominant in the past 5 years...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29859203/biological-therapies-for-eosinophilic-gastrointestinal-diseases
#14
Joshua B Wechsler, Ikuo Hirano
The scientific basis and the clinical application of monoclonal antibody therapies that target specific immunologic pathways for eosinophilic gastrointestinal diseases (EGIDs) are areas of active interest. There is a growing recognition of a subset of patients with eosinophilic esophagitis, or EoE, whose disease does not respond well to topical steroids or elimination diets. In addition, long-term use of corticosteroids presents risks. Systemic therapy with a biologic agent offers potential advantages as a global approach that could limit the need for multiple, locally active medical therapies and allergen avoidance...
May 30, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29858524/use-of-a-national-database-to-assess-pediatric-emergency-care-across-u-s-emergency-departments
#15
Kenneth A Michelson, Todd W Lyons, Joel D Hudgins, Jason A Levy, Michael C Monuteaux, Jonathan A Finkelstein, Richard G Bachur
OBJECTIVES: Differences in emergency care for children exist between general and pediatric emergency departments (EDs). Some pediatric quality measures are available but are not routinely employed nationwide. We sought to create a short list of applied measures that would provide a starting point for EDs to measure pediatric emergency care quality, and to compare care between general and pediatric EDs for these measures. METHODS: Previously reported lists comprising 465 pediatric emergency care quality measures were reconciled...
June 2, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29851766/management-of-paediatric-ulcerative-colitis-part-1-ambulatory-care-an-evidence-based-guideline-from-ecco-and-espghan
#16
Dan Turner, Frank M Ruemmele, Esther Orlanski-Meyer, Anne M Griffiths, Javier Martin de Carpi, Jiri Bronsky, Gabor Veres, Marina Aloi, Caterina Strisciuglio, Christian P Braegger, Amit Assa, Claudio Romano, Séamus Hussey, Michael Stanton, Mikko Pakarinen, Lissy de Ridder, Konstantinos Katsanos, Nick Croft, Victor Navas-López, David C Wilson, Sally Lawrence, Richard K Russell
BACKGROUND: The contemporary management of ambulatory ulcerative colitis (UC) continues to be challenging with ∼20% of children needing a colectomy within childhood years. We thus aimed to standardize daily treatment of paediatric UC and inflammatory bowel diseases (IBD)-unclassified through detailed recommendations and practice points. METHODS: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the Paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)...
May 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29850218/outcome-of-primary-nonpenetrating-deep-sclerectomy-in-patients-with-steroid-induced-glaucoma
#17
Abdelhamid Elhofi, Hany Ahmed Helaly
Purpose: To evaluate the outcome of primary nonpenetrating deep sclerectomy (NPDS) in patients with steroid-induced glaucoma. Methods: This was a retrospective interventional clinical study that included 60 eyes of 60 steroid-induced glaucoma patients that had undergone NPDS. Patients were followed up for 4 years. Data from the records was retrieved as regards corrected distance visual acuity (CDVA), intraocular pressure (IOP), visual field mean defect (dB), and number of antiglaucoma medications needed if any...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29850203/clinical-and-genetic-features-of-tubulointerstitial-nephritis-and-uveitis-syndrome-with-long-term-follow-up
#18
Hiroaki Kanno, Kyoko Ishida, Wataru Yamada, Ikumi Shiraki, Hiroki Murase, Yuka Yamagishi, Kiyofumi Mochizuki
Purpose: To investigate the clinical manifestations, prognosis, and HLA-type of tubulointerstitial nephritis and uveitis syndrome (TINU) with long-term follow-up. Methods: Clinical data of five patients with TINU were retrospectively reviewed. Results: The mean age was 15.8 years. The mean follow-up periods were 54.0 months. The initial subjective symptoms were bulbar injection (100%), ocular pain (80%), and blurred vision (60%). The medical department that the patients visited first was ophthalmology in 4 (80%) cases...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29847195/evaluating-the-novel-application-of-cyclosporine-0-1-in-ocular-surface-disease
#19
Konstadinos G Boboridis, Anastasios G P Konstas
Ocular surface disease (OSD) is a highly prevalent symptomatic condition caused by dry eye disease (DED), intrinsic, environmental, or iatrogenic causes. It affects patient's visual function and quality of life. Its pathophysiology is centered on tear hyperosmolarity, inflammation, and epithelial damage. Current management is suboptimal and includes artificial tear supplementation and short-term use of topical steroids in severe cases. The recent approval of cyclosporine 0.1% has transformed management strategies of severe DED and moderate-to-severe OSD...
May 30, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29807438/steroid-versus-antibiotic-drops-in-the-prevention-of-postoperative-myringotomy-tube-complications
#20
Sameer A Alvi, Joel W Jones, Paul Porter, Mollie Perryman, Karen Nelson, Carrie L Francis, Christopher G Larsen
OBJECTIVES: To determine the incidence of early postoperative tympanostomy tube insertion otorrhea and obstruction in pediatric patients receiving antibiotic ear drops with or without steroid perioperatively. METHODS: A retrospective chart review was performed on patients who underwent outpatient myringotomy and tube placement. Patients from June 2013 to February 2014 received ciprofloxacin/dexamethasone perioperatively while patients from May 2014 to April 2015 received ofloxacin...
May 1, 2018: Annals of Otology, Rhinology, and Laryngology
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