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Colorectal polypectomy

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https://www.readbyqxmd.com/read/29344790/prospective-analysis-of-delayed-colorectal-post-polypectomy-bleeding
#1
Soo-Kyung Park, Jeong Yeon Seo, Min-Gu Lee, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Hungdai Kim, Hyung Ook Kim, Kyung Uk Jung, Ho-Kyung Chun, Dong Il Park
BACKGROUNDS/AIMS: Although post-polypectomy bleeding is the most frequent complication after colonoscopic polypectomy, only few studies have investigated the incidence of bleeding prospectively. The aim of this study was to investigate the incidence of delayed post-polypectomy bleeding and its associated risk factors prospectively. METHODS: Patients who underwent colonoscopic polypectomy at Kangbuk Samsung Hospital from January 2013 to December 2014 were prospectively enrolled in this study...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29316779/double-balloon-endoscopy-after-incomplete-colonoscopy-and-its-comparison-with-computed-tomography-colonography
#2
Carlijn Hermans, Dennis van der Zee, Lennard Gilissen
Background/Aims: Because of the national screening program for colorectal carcinoma in The Netherlands, the number of colonoscopies has increased. In case of incomplete colonoscopy, computed tomography colonography (CTC) and double-balloon colonoscopy (DBc) are alternative options. This study evaluated cecal intubation rate and pathology detection rate in the previously unexplored part of the colon, complication rate of DBc, and CTC results after incomplete colonoscopy. Methods: Retrospective observational study in a tertiary referral hospital regarding DBc and CTC reports from cases with incomplete colonoscopy...
January 10, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29276220/metachronous-neoplasia-and-local-recurrence-after-colorectal-endoscopic-submucosal-dissection
#3
Daisuke Takei, Keita Harada, Shiho Takashima, Toshihiro Inokuchi, Asuka Nakarai, Yusaku Sugihara, Masanobu Takahara, Sakiko Hiraoka, Hiroyuki Okada
Several reports discussed colonoscopic surveillance after polypectomy and endoscopic mucosal resection (EMR) for colorectal polyps, but only a few reports focused on prognostic analyses, and none involved metachronous neoplasia after colorectal endoscopic submucosal dissection (ESD). We conducted the present study to assess the risk of adenoma recurrence requiring endoscopic treatment, and to establish appropriate post-ESD colonoscopic surveillance. We enrolled 116 patients who had undergone colorectal ESD at Okayama University Hospital between February 2008 and July 2014 and had been followed-up >12 months...
December 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29250580/a-prospective-comparison-of-cold-snare-polypectomy-using-traditional-or-dedicated-cold-snares-for-the-resection-of-small-sessile-colorectal-polyps
#4
Jeremy P Dwyer, Jonathan Y C Tan, Paul Urquhart, Robyn Secomb, Catherine Bunn, John Reynolds, Richard La Nauze, William Kemp, Stuart Roberts, Gregor Brown
Background and study aims:  The evidence for efficacy and safety of cold snare polypectomy is limited. The aim of this study was to assess the completeness of resection and safety of cold snare polypectomy, using either traditional or dedicated cold snares. Patients and methods:  This was a prospective, non-randomized study performed at a single tertiary hospital. Adult patients with at least one colorectal polyp (size ≤ 10 mm) removed by cold snare were included...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29249913/new-strategies-to-improve-polypectomy-during-colonoscopy
#5
Michael B Wallace
In the United States, colorectal cancer (CRC) is the second-leading cause of cancer-related deaths. The most effective strategy for prevention of CRC is to screen for and remove precancerous polyps. There are various ways to screen for CRC. In the United States, the most common method is colonoscopy. Polyps are classified primarily through pathology. Size is the primary risk factor for malignancy. In general, the bigger the polyp, the greater the risk for malignancy. There are 3 basic options for removal: standard polypectomy; advanced resection techniques, known as endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD); and surgical removal...
October 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29231190/lesions-of-all-types-exist-in-colon-polyps-of-all-sizes
#6
Kevin O Turner, Robert M Genta, Amnon Sonnenberg
OBJECTIVES: Although large polyps are known to harbor more advanced neoplasia than small polyps, the extent of the relationship between size and type is not fully known. The study aim was to establish benchmarks for the prevalence of different histologic polyp types among varying size categories. METHODS: The Miraca Life Sciences Database is an electronic repository of histopathologic patient records from private practices throughout the United States. We extracted the records of 483,998 unique patients who underwent colonoscopy with polypectomy between January 2008 and December 2014...
December 12, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29159277/development-of-a-porcine-model-for-assessment-of-mucosal-repair-following-endoscopic-resection-of-the-lower-gastrointestinal-tract
#7
Nicolas Etchepare, Jérémy Bregeon, Lucille Quénéhervé, Sami Haddara, Yann Touchefeu, Michel Neunlist, Emmanuel Coron
Background and aims:  Endoscopic mucosal resection (EMR) is widely performed for the treatment of colorectal polyps. However, the pathophysiological mechanisms of mucosal repair, including in situations at high risk of post-polypectomy bleeding, remain largely unknown. The objective of our study was to develop a porcine model of EMR in the lower gastrointestinal tract to monitor mucosal wound healing over time. Methods:  Under general anesthesia, five large wounds were created in the lower gastrointestinal tract at different times, i...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29157094/tead4-promotes-colorectal-tumorigenesis-via-transcriptionally-targeting-yap1
#8
Jia-Yin Tang, Chen-Yang Yu, Yu-Jie Bao, Lu Chen, Jinxian Chen, Sheng-Li Yang, Hao-Yan Chen, Jie Hong, Jing-Yuan Fang
TEAD4 (TEA domain family member 4) was recently revealed as an oncogenic character in tumorigenesis. However, its role remains unclear in colorectal tumorigenesis. Here, we firstly found that the expression level of TEAD4 was significantly elevated in clinical samples of colorectal adenomas (CRA) and correlated with the size and histological type of CRA. Moreover, patients with higher TEAD4 expression in normal colon mucosa are more prone to be recurrent after polypectomy. TEAD4 knockdown significantly inhibited colorectal cell proliferation in vitro and suppressed tumor growth in vivo...
November 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29151306/evaluation-of-risk-factors-for-the-recurrence-of-colorectal-polyps-and-colorectal-cancer
#9
Öztürk Ateş, Bülent Sivri, Saadettin Kılıçkap
Background/aim: Colorectal adenomatous polyps are precursors of colorectal cancer (CRC), which can be prevented with surveillance colonoscopy. This study aimed to assess risk factors for the recurrence of colorectal polyps and CRC following polypectomy. Materials and methods: In this single-center trial, a total of 510 patients who applied to the endoscopy unit of Hacettepe University Hospital for various reasons and who were diagnosed with at least one colorectal adenomatous polyp between 2000 and 2010 were retrospectively analyzed...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29122600/width-and-depth-of-resection-for-small-colorectal-polyps-hot-versus-cold-snare-polypectomy
#10
Sho Suzuki, Takuji Gotoda, Chika Kusano, Hisatomo Ikehara, Akihiro Sugita, Misa Yamauchi, Mitsuhiko Moriyama
BACKGROUND AND AIMS: Curability is associated with resection width and depth in polypectomy. We evaluated the resection width and depth achieved with hot snare polypectomy (HSP) and cold snare polypectomy (CSP) for small colorectal polyps. METHODS: In this single-center, prospective, randomized controlled study, patients with rectal or rectosigmoid polyps ≤10 mm in diameter were treated with HSP or CSP. Resection width was evaluated as mucosal defect size, measured immediately postprocedure and 1 day later...
November 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29105290/endoscopic-resection-of-large-colorectal-adenomas-clinical-experience-of-a-tertiary-referral-center
#11
Liat Mlynarsky, Shira Zelber-Sagi, Eliaz Miller, Revital Kariv
BACKGROUND: Colorectal cancer is a leading cause for cancer-related mortality. Adenomatous polyps are typically resected endoscopically to prevent cancer while giant and complex polyps are managed surgically. No criteria clearly define the indications for surgical versus endoscopic resection. AIM: To evaluate factors associated with short-term efficacy and safety of endoscopic resection of large (≥20mm) and giant (≥40mm) adenomas. METHODS: Consecutive cases with colonic adenomas larger than 20mm, resected endoscopically were included...
November 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29104470/critical-role-of-p53-and-k-ras-in-the-diagnosis-of-early-colorectal-cancer-a-one-year-single-center-analysis
#12
Hui-Ying Lu, Ri-Tian Lin, Guang-Xi Zhou, Tian-Ming Yu, Zhan-Ju Liu
Background: Colorectal cancer (CRC) is strongly associated with colorectal polyps, which has become the third most common cancer in China. In the present study, we revealed the susceptible population and risk factors of colorectal polyps, and analyzed the expression of Ki-67, p53 and K-ras in the intestinal mucosa of patients with colorectal polyps in order to explore their significance in the detection and prognosis of CRC at an early stage. Materials and Methods: Total 801 cases of colorectal polyps were collected during endoscopic resection including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29103541/problematic-colorectal-polyps-is-it-cancer-and-what-do-i-need-to-do-about-it
#13
REVIEW
Maurice B Loughrey, Neil A Shepherd
Two issues commonly arise for pathologists reporting adenomatous polyps of the colorectum. Particularly problematic within large sigmoid colonic adenomas is the distinction between benign misplacement of epithelium into the submucosa and invasive malignancy. This distinction requires careful morphologic evaluation of key discriminatory features, assisted only rarely by the application of selected adjunctive immunohistochemistry. Following a diagnosis of adenocarcinoma within a polypectomy or other local excision specimen, systematic assessment is required of features that may indicate the risk of residual local and/or nodal neoplastic disease and inform management decision-making regarding the need for further endoscopic or surgical intervention...
December 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29089272/post-polypectomy-bleeding-after-colonoscopy-on-uninterrupted-aspirin-non-steroideal-antiflammatory-drugs-systematic-review-and-meta-analysis
#14
REVIEW
Flavia Pigò, Helga Bertani, Giuseppe Grande, Abate Federica, Sara Vavassori, Rita Luisa Conigliaro
BACKGROUND AND AIM: The aim of this systematic review and meta-analysis was to assess the risk of post-polypectomy bleeding (PPB) in patients that underwent colorectal polypectomy and exposed to ASA/NSAIDs. METHODS: Relevant publications were identified in MEDLINE/EMBASE for the period 1950-2016. Studies with specified ASA/NSAIDs exposure and bleeding rate were included. Study quality was ascertained according to Newcastle-Ottawa Scale. Forest plot was based on fixed or random effect models in relation to the heterogeneity...
October 18, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29082224/repeat-colonoscopy-within-6-months-after-initial-outpatient-colonoscopy-in-ontario-a-population-based-cross-sectional-study
#15
Lawrence Paszat, Rinku Sutradhar, Nancy N Baxter, Jill Tinmouth, Linda Rabeneck
BACKGROUND: The goal of this study is to examine utilization of early repeat colonoscopy ≤ 6 months after an index procedure. METHODS: We identified persons having repeat colonoscopy ≤ 6 months following outpatient colonoscopy without prior colonoscopy ≤ 5 years or prior diagnosis of colorectal cancer (CRC). We modeled repeat colonoscopy using a generalized estimating equation with an exchangeable correlation structure to account for clustering of patients by endoscopist...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29074726/outcomes-following-polypectomy-for-malignant-colorectal-polyps-are-similar-to-those-following-surgery-in-the-general-population
#16
Anthony Lopez, Anne-Marie Bouvier, Valérie Jooste, Vanessa Cottet, Gaëlle Romain, Jean Faivre, Sylvain Manfredi, Come Lepage
OBJECTIVE: Population-based studies on colorectal malignant polyps (MPs) are scarce. The aim of this study was to describe time trends in the incidence of colorectal MPs before and after the introduction of a colorectal mass-screening programmein 2003 and to assess outcomes (survival and recurrence) after endoscopic or surgical resection in patients with MPs. DESIGN: We included 411 patients with MPs diagnosed between 1982 and 2011 in a well-defined population. Age-standardised incidence rates were calculated...
October 26, 2017: Gut
https://www.readbyqxmd.com/read/29072082/chemoprevention-of-polyp-recurrence-with-curcumin-followed-by-silibinin-in-a-case-of-multiple-colorectal-adenomas
#17
Vicente Alfonso-Moreno, Antonio López-Serrano, Eduardo Moreno-Osset
Chemoprevention is a practical approach to reduce the risk of various cancers including colorectal cancer (CRC). The goal is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent its progression to CRC. Curcumin and silibinin prevent intestinal polyp formation in mice. Curcumin sensitizes silymarin to exert synergistic anticancer activity in colon cancer cells. Patients presenting with multiple colorectal adenomatous polyps (MCRA) have a high lifetime risk for CRC. We present a 57-year-old man with MCRA, without deleterious germline APC or MYH mutations...
October 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29046738/colorectal-cancer-incidence-in-path_mlh1-carriers-subjected-to-different-follow-up-protocols-a-prospective-lynch-syndrome-database-report
#18
Toni Seppälä, Kirsi Pylvänäinen, Dafydd Gareth Evans, Heikki Järvinen, Laura Renkonen-Sinisalo, Inge Bernstein, Elke Holinski-Feder, Paola Sala, Annika Lindblom, Finlay Macrae, Ignacio Blanco, Rolf Sijmons, Jacqueline Jeffries, Hans Vasen, John Burn, Sigve Nakken, Eivind Hovig, Einar Andreas Rødland, Kukatharmini Tharmaratnam, Wouter H de Vos Tot Nederveen Cappel, James Hill, Juul Wijnen, Mark Jenkins, Maurizio Genuardi, Kate Green, Fiona Lalloo, Lone Sunde, Miriam Mints, Lucio Bertario, Marta Pineda, Matilde Navarro, Monika Morak, Ian M Frayling, John-Paul Plazzer, Julian R Sampson, Gabriel Capella, Gabriela Möslein, Jukka-Pekka Mecklin, Pål Møller
BACKGROUND: We have previously reported a high incidence of colorectal cancer (CRC) in carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy including polypectomy. METHODS: The cohort included Finnish carriers enrolled in 3-yearly colonoscopy (n = 505; 4625 observation years) and carriers from other countries enrolled in colonoscopy 2-yearly or more frequently (n = 439; 3299 observation years). We examined whether the longer interval between colonoscopies in Finland could explain the high incidence of CRC and whether disease expression correlated with differences in population CRC incidence...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29042789/linked-color-imaging-combined-with-the-nice-classification-system-for-optical-diagnosis-of-colon-polyps-new-image-enhanced-endoscopic-technology-for-pathological-prediction
#19
Chi-Huan Wu, Tsung-Hsing Chen, Chen-Ming Hsu, Ming-Yao Su, Cheng-Tang Chiu, Ren-Chin Wu, Cheng-Chou Lai
INTRODUCTION: Linked-color imaging (LCI) is a recently developed system used in endoscopy. It creates clear and bright endoscopic images using short-wavelength, narrow-band laser light combined with white laser light. The illuminating light and signal processing emphasize slight color differences in abnormal regions that approximate the normal color of the mucosa. As a result, regions initially appearing red become a deeper shade of red, while regions originally appearing white become brighter, yet with natural tones...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28994567/underwater-endoscopic-mucosal-resection-uemr-an-alternative-for-removal-of-large-sessile-colorectal-polyps
#20
Dalbir S Sandhu, Ye J Lee, Henning Gerke
BACKGROUND AND AIMS: Large sessile/flat colonic polyps are traditionally removed by lift polypectomy. Underwater endoscopic mucosal resection (UEMR) is a novel technique where air is suctioned out and replaced by water to decompress the colon so that the flat lesions assumes a more polypoid shape facilitating its removal with the standard snare resection. We report the feasibility and safety in our series of patients utilizing this technique. PATIENTS AND METHODS: A retrospective, observational study of all patients who underwent removal of large colonic polyps (>10 mm) over a period of 3 years (January 2012 - January 2015) at a tertiary care center by UEMR were included in the study...
October 9, 2017: Minerva Gastroenterologica e Dietologica
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