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https://www.readbyqxmd.com/read/27852461/the-development-of-intensive-care-in-the-military-environment
#1
REVIEW
Matthew J Roberts
If the history of critical care is to be addressed, the starting point must be the fundamental and defining qualities of intensive care units. These are the concentration of the sickest patients in a defined area of the hospital, staffed by the personnel most able to care for them (by virtue of specialist training), and the application of the most advanced monitoring or therapeutic techniques available at the time. In the military environment, the ability to provide critical care to ill or injured servicemen has developed in tandem with the civilian experience, but the pressures of the austere environment of the battlefield have, at times, held back military medical services from providing the highest level of care that servicemen might deserve and, indeed, expect in civilian life...
October 2016: Journal of Anesthesia History
https://www.readbyqxmd.com/read/27822364/new-withanolides-with-trail-sensitizing-effect-from-physalis-pubescens-l
#2
Li-Xia Chen, Gui-Yang Xia, Hao He, Jian Huang, Feng Qiu, Xiao-Lin Zi
Physalis pubescens L. plant produces nutritious and healthy fruits, called husk tomato or hairy ground cherry. However, its bioactive components are largely unknown. Four new withanolide steroids (1-4) together with one known withanolide (5) were isolated from the extract of P. pubescens L. and their chemical structures were established by extensive spectroscopic analyses. Compounds 1, 3 and 5 showed potent growth inhibitory effects against four human renal cell carcinoma (RCC) cell lines (i.e. 786-O, A-498, Caki-2 and ACHN)...
2016: RSC Advances
https://www.readbyqxmd.com/read/27737327/the-coexistence-of-hypercalcemia-and-hypoglycemia-in-a-patient-with-a-renal-tumor-and-b-cell-lymphoma
#3
Jimena Soutelo, Sofía Moldes, Cielo Frisone, Laura Salvá, Cecilia Agostinis, Gabriel Faraj
Paraneoplastic syndromes are a heterogeneous group of malignant diseases caused by events which involve endocrine, immune and metabolic aspects and whose symptoms vary according to the substance produced and the primary tumor. Hypercalcemia is a frequent complication in cancer patients. Prognosis of cancer patients with hypercalcemia is usually poor. A factor called parathyroid hormone related peptide, whose actions are similar to those of the parathyroid hormone, is thought to be the most common cause of malignancy associated hypercalcemia...
October 10, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27686524/renal-cell-carcinoma-survival-and-body-mass-index-a-dose-response-meta-analysis-reveals-another-potential-paradox-within-a-paradox
#4
REVIEW
M Bagheri, J R Speakman, F Shemirani, K Djafarian
BACKGROUND: In healthy subjects increasing body mass index (BMI) leads to greater mortality from a range of causes. Following onset of specific diseases, however, the reverse is often found: called the 'obesity paradox'. But we recently observed the phenomenon called the 'paradox within the paradox' for stroke patients. OBJECTIVE: The objective of our study was to examine the effect of each unit increase in BMI on renal cancer-specific survival (CSS), cancer-specific mortality, overall survival (OS) and overall mortality...
November 16, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27680188/-immunooncology-in-urologic-cancers-current-status
#5
M-O Grimm
Immune checkpoint inhibitors are establishing itselves as a new systemic treatment option (in addition to chemotherapy and targeted therapy) for metastatic tumours. (Re)activating the immune system, these antibodies may lead to impressive remissions lasting for a long time in some patients. Regarding urological tumours, the anti-PD-1 antibody Nivolumab (Opdivo(®)) has been approved this year for advanced, previously treated renal cell carcinoma. In the United States, Atezolizumab (Tecentriq(®)) has been approved for metastatic urothelial carcinoma after platinum-based chemotherapy...
September 2016: Aktuelle Urologie
https://www.readbyqxmd.com/read/27566592/promising-pharmacological-profile-of-a-kunitz-type-inhibitor-in-murine-renal-cell-carcinoma-model
#6
Jean Gabriel de Souza, Katia Lp Morais, Eduardo Anglés-Cano, Pamela Boufleur, Evandro Sobroza de Mello, Durvanei Augusto Maria, Clarice Silvia Taemi Origassa, Hamilton de Campos Zampolli, Niels Olsen Saraiva Câmara, Carolina Maria Berra, Rosemary Viola Bosch, Ana Marisa Chudzinski-Tavassi
Renal cell carcinoma (RCC), also called kidney cancer or renal adenocarcinoma, is highly resistant to current treatments. It has been previously reported that a Kunitz-type inhibitor domain-containing protein, isolated from the salivary glands of the Amblyomma cajennense tick, triggers apoptosis in murine renal adenocarcinoma cells (Renca) by inhibiting the proteasome and endoplasmic reticulum stress. Of note, Amblyomin-X is the corresponding recombinant protein identified in the cDNA library from A. cajennense salivary glands...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27515408/telbivudine-therapy-for-chronic-hepatitis-b-a-journey-to-identify-super-responders-and-to-optimize-treatment-using-the-roadmap-model
#7
Jia-Horng Kao, Tarik Asselah, Xiao-Guang Dou, Kamal Hamed
Hepatitis B virus (HBV) infection is one of the most serious health problems worldwide with a high risk for cirrhosis and liver cancer. Several antiviral agents have been approved for the treatment of chronic hepatitis (CHB), leading to a rapid reduction in HBV DNA and normalization of serum alanine aminotransferase (ALT) levels. Telbivudine, a potent inhibitor of HBV replication, has been shown to be well tolerated. Due to the emergence of drug resistance, optimization strategies for telbivudine therapy have been shown to improve patient responses...
August 11, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27489720/use-of-remote-blood-releasing-system-for-red-cell-transfusion-in-hospice-care-center
#8
Kwok Ying Chan, Rock Yuk Yan Leung, Ka Chi Cheung, Clarence Lam, Eleanor Koo, Sylvia Ng
OBJECTIVES: It is quite common to have advanced cancer or end-stage renal disease patients for regular or even frequent blood transfusion in palliative care. However, due to geographical reason in some hospice centers, blood transfusion is sometimes difficult if blood bank is closed during non-office hour or not available. METHODS: Here, we reported a new blood releasing system, that is, remote blood releasing system, that could be used safely by nursing staff alone when the blood bank was closed during the night time and holiday...
2016: SAGE open medical case reports
https://www.readbyqxmd.com/read/27478825/elderly-and-nonelderly-use-of-a-dedicated-ambulance-corps-emergency-medical-services-in-taiwan
#9
Chien-Chia Huang, Wei-Lung Chen, Chien-Chin Hsu, Hung-Jung Lin, Shih-Bin Su, How-Ran Guo, Chien-Cheng Huang, Pi-Ching Chen
Backgrounds and Aim. Taiwan's population is gradually aging; however, there are no comparative data on emergency medical services (EMS) use between the elderly and nonelderly. Methods. We analyzed the emergency calls dealt with between January 1 and April 4, 2014, by EMS in one city in Taiwan. All calls were divided into two groups: elderly (≥65 years) and nonelderly (<65 years). Nontransport and transport calls were compared between the groups for demographic characteristics, transport time, reasons for calling EMS, vital signs, and emergency management...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27318796/the-development-of-immunotherapy-in-older-adults-new-treatments-new-toxicities
#10
REVIEW
Carole Helissey, Cécile Vicier, Stéphane Champiat
Monoclonal antibodies targeting immune checkpoint molecules CTLA-4, PD-1 or PD-L1 are emerging as promising anticancer therapeutics in multiple cancer subtypes resulting in remarkable and long-lasting clinical responses. These immune checkpoint blockers (ICBs) have already obtained approval for the treatment of patients with metastatic melanoma, advanced/refractory non-small cell lung cancer and renal cell cancer. ICBs enhance immune responses against cancer cells but can also lead to inflammatory side effects called immune-related adverse events (irAEs)...
September 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27146870/-therapy-monitoring-and-management-of-adverse-events-in-pd-1-pd-l1-immune-checkpoint-inhibition
#11
H Oppel-Heuchel, M-O Grimm
Nivolumab was recently approved as the first inhibitor of the programmed death 1 (PD-1) receptor and its ligand (PD-L1) for the treatment of urological cancer, namely metastasized renal cell carcinoma after prior therapy. The use of this new immunotherapy requires special therapy monitoring and management of side effects. An increase of immune cells around the tumor can initially mimic progression (so-called pseudoprogression). Treatment-associated side effects of higher grade according to the common terminology criteria for adverse events (CTCAE grades 3 or 4) are relatively rare; however, new immune-mediated side effects can occur and affect the skin, liver (hepatitis), kidneys (nephritis), gastrointestinal tract (diarrhea and colitis), lungs (pneumonitis) and endocrine organs (hyperthyroidism, hypothyroidism and hypophysitis)...
May 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27119960/-renaissance-of-immuno-oncology-for-urological-tumors-current-status
#12
M-O Grimm, Y Winkler, I Fetter, H Oppel-Heuchel
With the advent of immune checkpoint inhibitors, immunotherapy has gained new importance in oncology. Current research is focused on the cytotoxic T‑lymphocyte antigen 4 (CTLA4), programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) immune checkpoints. The CTLA4 antibody ipilimumab (melanoma) as well as the PD-1 antibodies nivolumab (melanoma, non-small cell lung cancer and renal cell carcinoma) and pembrolizumab (melanoma) are approved for the treatment of metastatic disease in Europe. Immune checkpoint inhibitors (re)activate the immune system against cancer cells and appear to be more effective than current standards for many tumors...
May 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27111595/-case-report-on-treatment-of-metastatic-breast-cancer-with-trastuzumab-during-pregnancy
#13
R Rasenack, N Gaupp, B Rautenberg, E Stickeler, H Prömpeler
The increasing number of pregnant breast cancer patients calls for a therapy that is as efficient as possible. After 10 years of collecting data on pregnant breast cancer patients in the German Breast Group (GBG), proposals for diagnostic measures and therapy regarding this special situation have been developed on the basis of 500 observed cases. Chemotherapy is regarded as safe from the 14(th) week of gestation on, but it is strongly advised not to use trastuzumab. Adverse outcomes for the newborn were predominantly observed in cases of early preterms...
April 2016: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/27092549/metastatic-cancer-to-the-parotid
#14
Jonathan Clark, Steven Wang
In many regions of the world, the most common type of parotid malignancy is metastatic malignancy. Metastatic cutaneous squamous cell carcinoma and metastatic melanoma are the most common pathologies that metastasize to the parotid gland and cervical lymph nodes. Other more rare metastatic malignancies from cutaneous primary sites include Merkel cell carcinoma, pleomorphic sarcoma (previously called malignant fibrous histiocytoma) and metastatic basal cell carcinoma. Systemic metastases can also occur from tumors such as renal cell carcinoma...
2016: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/26982119/structural-transition-of-kidney-cystatin-in-dimethylnitrosamine-induced-renal-cancer-in-rats-identification-as-a-novel-biomarker-for-kidney-cancer-and-prognosis
#15
Anas Shamsi, Azaj Ahmed, Bilqees Bano
In our study renal cancer is induced in rats making use of dimethylnitrosamine (DMN). G1; Group 1 were control rats and G2; Group 2 rats were given a single intra-peritoneal injection of DMN of 50mg/kg body weight resulting in 100% incidences of renal tumors after 12 months. SEM and histopathology confirmed the presence of renal cancer in the DMN treated rats. Making use of ammonium sulphate precipitation and gel filtration chromatography on Sephacryl S-100HR column, a thiol protease inhibitor was isolated from kidney of control rats known as Rat kidney Cystatin (RKC) as well as from kidney of cancerous rat called as Cancerous Rat Kidney Cystatin (CRKC)...
March 16, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/26874776/management-of-toxicities-of-immune-checkpoint-inhibitors
#16
REVIEW
Lavinia Spain, Stefan Diem, James Larkin
Immune checkpoint inhibition with the anti-CTLA-4 antibody ipilimumab and the anti-PD-1 antibodies nivolumab and pembrolizumab has improved survival in metastatic melanoma, lung cancer and renal cancer. Use of these agents holds promise in other malignancies. The augmented immune response enabled by these agents has led to a particular group of side effects called immune-related adverse events (irAEs). The main irAEs include diarrhea, colitis, hepatitis, skin toxicities and endocrinopathies such as hypophysitis and thyroid dysfunction...
March 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/26759245/identification-of-dna-methylation-independent-epigenetic-events-underlying-clear-cell-renal-cell-carcinoma
#17
Elinne Becket, Sameer Chopra, Christopher E Duymich, Justin J Lin, Jueng Soo You, Kurinji Pandiyan, Peter W Nichols, Kimberly D Siegmund, Jessica Charlet, Daniel J Weisenberger, Peter A Jones, Gangning Liang
Alterations in chromatin accessibility independent of DNA methylation can affect cancer-related gene expression, but are often overlooked in conventional epigenomic profiling approaches. In this study, we describe a cost-effective and computationally simple assay called AcceSssIble to simultaneously interrogate DNA methylation and chromatin accessibility alterations in primary human clear cell renal cell carcinomas (ccRCC). Our study revealed significant perturbations to the ccRCC epigenome and identified gene expression changes that were specifically attributed to the chromatin accessibility status whether or not DNA methylation was involved...
April 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/26726440/quantum-dot-bead-dna-probe-based-hybridization-fluorescence-assays-on-microfluidic-chips
#18
Seshadri Reddy Ankireddy, Jongsung Kim
The development of chip-based, quantum dot (QD)-bead-DNA conjugate probes for hybridization detection is a prime research focus in the field of microfluidics. QD-Bead-DNA probe-based hybridization detection methods are often called "bead-based assays," and their success is substantially influenced by the dispensing and manipulation capabilities of microfluidic technology. Met was identified as a prognostic marker in different cancers including lung, renal, liver, head and neck, stomach, and breast. In this report, the cancer causing Met gene was detected with QDs attached to polystyrene microbeads...
October 2015: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/26474388/suppression-of-mitochondrial-respiration-with-auraptene-inhibits-the-progression-of-renal-cell-carcinoma-involvement-of-hif-1%C3%AE-degradation
#19
Yunseon Jang, Jeongsu Han, Soo Jeong Kim, Jungim Kim, Min Joung Lee, Soyeon Jeong, Min Jeong Ryu, Kang-Sik Seo, Song-Yi Choi, Minho Shong, Kyu Lim, Jun Young Heo, Gi Ryang Kweon
Renal cell carcinoma (RCC) progression resulting from the uncontrolled migration and enhanced angiogenesis is an obstacle to effective therapeutic intervention. Tumor metabolism has distinctive feature called Warburg effect, which enhances the aerobic glycolysis rapidly supplying the energy for migration of tumor. To manipulate this metabolic change characteristic of aggressive tumors, we utilized the citrus extract, auraptene, known as a mitochondrial inhibitor, testing its anticancer effects against the RCC4 cell line...
November 10, 2015: Oncotarget
https://www.readbyqxmd.com/read/26411549/postoperative-surveillance-imaging-for-patients-undergoing-nephrectomy-for-renal-cell-carcinoma
#20
REVIEW
Eric H Kim, Seth A Strope
The American Urological Association and the National Comprehensive Cancer Network guidelines regarding postoperative surveillance for renal cell carcinoma (RCC) have provided a standardized framework for imaging following nephrectomy. These stage-stratified recommendations are based on retrospective studies that identified the timeline and location of RCC recurrences. However, the simplified and generalizable protocols offered by the American Urological Association and the National Comprehensive Cancer Network are not without limitations...
December 2015: Urologic Oncology
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