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stearoyl desaturase

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https://www.readbyqxmd.com/read/28720051/plasma-and-amniotic-fluid-ppar%C3%AE-is-involved-in-the-lipid-metabolism-of-maternal-fetal-interface-cells
#1
Yan Cheng, Shuangping Liu, Ru Lin, Jue Wang, Ting Peng, Qingying Zhang, Haidong Cheng
OBJECTIVES: The aim of this study was at detecting the expression of peroxisome proliferator-activated receptor γ (PPARγ) in patients with gestational diabetes mellitus (GDM) and to investigate whether PPARγ regulates the lipid metabolism of maternal-fetal interface cells. METHODS: We detected the expression of PPARγ in the maternal plasma, fetal plasma and amniotic fluid of two groups of women with GDM or normal pregnancy using ELISA and western blot. Establish the cell models of the indirect coculture model and the separate culture model using BeWo cells and endometrial stromal cells (ESCs)...
July 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28710073/zinc-mediates-the-srebp-scd-axis-to-regulate-lipid-metabolism-in-caenorhabditis-elegans
#2
Jing-Jing Zhang, Jun-Jun Hao, Yu-Ru Zhang, Yan-Li Wang, Ming-Yi Li, Hui-Lai Miao, Xiao-Ju Zou, Bin Liang
Maintenance of lipid homeostasis is crucial for cells in response to lipid requirements or surplus. The SREBPs transcription factors play essential roles in regulating lipid metabolism and are associated with many metabolic diseases. However, SREBP regulation of lipid metabolism is still less understood. Here, we show that reduction of SBP-1, the only homologue of SREBPs in C. elegans, surprisingly leads to high level of zinc. On the contrary, zinc reduction by mutation of sur-7, encoding a member of the cation diffusion facilitator (CDF) family, restores the fat accumulation and fatty acid profile of sbp-1(ep79) mutant...
July 14, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28704514/feedback-activation-of-ampk-mediated-autophagy-acceleration-is-a-key-resistance-mechanism-against-scd1-inhibitor-induced-cell-growth-inhibition
#3
Akito Ono, Osamu Sano, Ken-Ichi Kazetani, Takamichi Muraki, Keisuke Imamura, Hiroyuki Sumi, Junji Matsui, Hidehisa Iwata
Elucidating the bioactive compound modes of action is crucial for increasing success rates in drug development. For anticancer drugs, defining effective drug combinations that overcome resistance improves therapeutic efficacy. Herein, by using a biologically annotated compound library, we performed a large-scale combination screening with Stearoyl-CoA desaturase-1 (SCD1) inhibitor, T-3764518, which partially inhibits colorectal cancer cell proliferation. T-3764518 induced phosphorylation and activation of AMPK in HCT-116 cells, which led to blockade of downstream fatty acid synthesis and acceleration of autophagy...
2017: PloS One
https://www.readbyqxmd.com/read/28693951/gene-silencing-of-stearoyl-acp-desaturase-enhances-the-stearic-acid-content-in-chlamydomonas-reinhardtii
#4
L de Jaeger, J Springer, E J H Wolbert, D E Martens, G Eggink, R H Wijffels
In this study, stearoyl-ACP desaturase (SAD), the enzyme that converts stearic acid into oleic acid, is silenced by artificial microRNA in the green microalga Chlamydomonas reinhardtii. Two different constructs, which target different positions on the mRNA of stearoyl-ACP desaturase, were tested. The mRNA levels for SAD were reduced after the silencing construct was induced. In one of the strains, the reduction in SAD mRNA resulted in a doubling of the stearic acid content in triacylglycerol molecules, which shows that stearic acid production in microalgae is possible...
June 30, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28676973/chronic-consumption-of-fructose-in-combination-with-trans-fatty-acids-but-not-with-saturated-fatty-acids-induces-nonalcoholic-steatohepatitis-with-fibrosis-in-rats
#5
Sugeedha Jeyapal, Uday Kumar Putcha, Venkata Surekha Mullapudi, Sudip Ghosh, Anil Sakamuri, Suryam Reddy Kona, Sai Santosh Vadakattu, Chandana Madakasira, Ahamed Ibrahim
PURPOSE: Consumption of Western diet high in fat and fructose has been attributed to the recent epidemic of nonalcoholic fatty liver disease (NAFLD). However, the impact of specific fatty acids on the progression of NAFLD to nonalcoholic steatohepatitis (NASH) is poorly understood. In the present study, we investigated the chronic effects of consumption of fructose in combination with saturated fatty acids (SFA) or trans fatty acids (TFA) on the development of NAFLD. METHODS: Male Sprague-Dawley rats were randomly assigned to six isocaloric starch/high fructose (44% of calories), high fat (39% calories) diet containing either starch-peanut oil, fructose-peanut oil, fructose-palmolein, fructose-clarified butter, fructose-coconut oil or fructose-partially hydrogenated vegetable oil and fed for 24 weeks...
July 4, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28667176/mir-212-5p-suppresses-lipid-accumulation-by-targeting-fas-and-scd1
#6
Yajie Guo, Junjie Yu, Chunxia Wang, Kai Li, Bin Liu, Ying Du, Fei Xiao, Shanghai Chen, Feifan Guo
MicroRNAs, a class of small non-coding RNAs, are implicated in controlling a variety of biological processes. We have shown that leucine deprivation suppresses lipogenesis by inhibiting fatty acid synthase (FAS) expression in the liver previously; the aim of our current study is to investigate which kind of microRNA is involved in the regulation of FAS expression in response to leucine deprivation. Here, we indicated that microRNA-212-5p specifically binds to mouse FAS 3'UTR and inhibits its activity. Leucine deficiency significantly increased the mRNA levels of miR-212-5p in the livers of mice...
June 30, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28659893/live-probiotic-lactobacillus-johnsonii-bs15-promotes-growth-performance-and-lowers-fat-deposition-by-improving-lipid-metabolism-intestinal-development-and-gut-microflora-in-broilers
#7
Hesong Wang, Xueqin Ni, Xiaodan Qing, Dong Zeng, Min Luo, Lei Liu, Guangyao Li, Kangcheng Pan, Bo Jing
Numerous studies have focused on the beneficial effects of probiotics in animals. Even so, additional information should be obtained about the mechanisms by which a useful probiotic strain successfully exerts such beneficial effects. In this study, we evaluated the effect of the dietary supplementation of both live and disrupted Lactobacillus johnsonii (LJ) strain BS15 in broilers at different ages. Specifically, growth performance, lipid metabolism, gut microbiota, intestinal development, and digestive ability of the broilers were assessed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28650445/a-distinct-function-of-the-retinoblastoma-protein-in-the-control-of-lipid-composition-identified-by-lipidomic-profiling
#8
H Muranaka, A Hayashi, K Minami, S Kitajima, S Kohno, Y Nishimoto, N Nagatani, M Suzuki, L A N Kulathunga, N Sasaki, N Okada, T Matsuzaka, H Shimano, H Tada, C Takahashi
Here, by combining lipidomics with transcriptome analysis, we demonstrate that Rb depletion in mouse embryonic fibroblastss induces significant alterations in their lipid composition. We discovered that Rb depletion induced increase in lysophosphatidylserine, diacylglycerol (DAG), fatty acid (FA), acylcarnitine, phosphatidylcholine (PC), arachidonoyl ethanolamine, and decrease in phosphatidylglycerol, monoacylglycerol, without change in total lipid per protein levels. Analysis of the acyl chain composition of DAG, PC and phosphatidylserine revealed increase of saturated and mono-unsaturated acyl chains with specific carbon chain length...
June 26, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28647567/stearoyl-coa-desaturase-regulates-sorafenib-resistance-via-modulation-of-er-stress-induced-differentiation
#9
Mark Kin Fai Ma, Eunice Yuen Ting Lau, Doris Hoi Wing Leung, Jessica Lo, Nicole Pui Yu Ho, Lily Kwan Wai Cheng, Stephanie Ma, Chi Ho Lin, John A Copland, Jin Ding, Regina Cheuk Lam Lo, Irene Oi Lin Ng, Terence Kin Wah Lee
BACKGROUND & AIMS: We investigated the functional role and clinical significance of Stearoyl CoA desaturase-1 (SCD1) mediated endoplasmic reticulum (ER) stress in regulation of liver tumor-initiating cells (T-ICs) and sorafenib resistance, aiming to develop a novel therapeutic strategy against hepatocellular carcinomas (HCCs) METHODS: We evaluated the clinic-pathological relevance of SCD1 and its correlation with sorafenib resistance in large cohorts of HCC clinical samples by qPCR and immunohistochemical analyses...
June 22, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28643621/linoleic-acid-%C3%AE-linolenic-acid-and-enterolactone-affect-lipid-oxidation-and-expression-of-lipid-metabolism-and-antioxidant-related-genes-in-hepatic-tissue-of-dairy-cows
#10
Émilie Fortin, Richard Blouin, Jérôme Lapointe, Hélène V Petit, Marie-France Palin
Although beneficial effects have been attributed to PUFA supplementation in high-yielding dairy cows, diets rich in PUFA may also increase oxidative stress in tissues such as the liver. To fully exploit the health benefits of PUFA, we believe that the addition of natural antioxidants could help in preventing oxidative damage. Using an in vitro precision-cut liver slices (PCLS) tissue culture system, we investigated the effects of different linoleic acid (LA, n-6):α-linolenic acid (ALA, n-3) ratios (LA:ALA ratio of 4, LA:ALA ratio of 15 and LA:ALA ratio of 25) in the presence or absence of the antioxidant enterolactone (ENL) on (1) the mRNA abundance of genes with key roles in hepatic lipid metabolism, oxidative stress response and inflammatory processes, (2) oxidative damages to lipids and proteins and (3) superoxide dismutase activity in early-lactating dairy cows...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28633686/polymorphisms-of-the-tnf-%C3%AE-gene-interact-with-plasma-fatty-acids-on-inflammatory-biomarker-profile-a-population-based-cross-sectional-study-in-s%C3%A3-o-paulo-brazil
#11
Erica Oki, Marina N Norde, Antônio A F Carioca, José M P Souza, Inar A Castro, Dirce M L Marchioni, Regina M Fisberg, Marcelo M Rogero
The aim of the present study was to investigate the relationship of four TNF-α SNP with inflammatory biomarkers and plasma fatty acids (FA), and the interaction among them in a population-based, cross-sectional study in São Paulo, Brazil. A total of 281 subjects, aged >19 and <60 years, participated in a cross-sectional, population-based study performed in Brazil. The following SNP spanning the TNF-α gene were genotyped: -238G/A (rs361525), -308G/A (rs1800629), -857C/T (rs1799724) and -1031T/C (rs1799964)...
June 21, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28628115/stearoyl-coa-desaturase-1-regulates-lung-cancer-stemness-via-stabilization-and-nuclear-localization-of-yap-taz
#12
A Noto, C De Vitis, M E Pisanu, G Roscilli, G Ricci, A Catizone, G Sorrentino, G Chianese, O Taglialatela-Scafati, D Trisciuoglio, D Del Bufalo, M Di Martile, A Di Napoli, L Ruco, S Costantini, Z Jakopin, A Budillon, G Melino, G Del Sal, G Ciliberto, R Mancini
This corrects the article DOI: 10.1038/onc.2017.75.
June 19, 2017: Oncogene
https://www.readbyqxmd.com/read/28627277/anti-acne-drugs-in-phase-1-and-2-clinical-trials
#13
REVIEW
Christos C Zouboulis, Clio Dessinioti, Fragkiski Tsatsou, Harald P M Gollnick
Despite the impressive increase of knowledge on acne etiology accumulated during the last 20 years, few efforts have been overtaken to introduce new therapeutic regiments targeting the ideal treatment of acne. The increasing emergence of microbial resistance associated with antibiotics, teratogenicity, particularly associated with systemic isotretinoin, and the need for an adverse drug profile, which can be tolerated by the patient, make the need of new pathogenesis relevant anti-acne agents an emerging issue...
July 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28626141/dietary-starfish-oil-prevents-hepatic-steatosis-and-hyperlipidemia-in-c57bl-6n-mice-fed-high-fat-diet
#14
Fumiaki Beppu, Haoqi Li, Kazuaki Yoshinaga, Toshiharu Nagai, Akihiko Yoshinda, Atsushi Kubo, Jota Kanda, Naohiro Gotoh
Starfish oil (SO) is characterized by functional lipids, including n-3 polyunsaturated fatty acid (both in the form of triacylglycerol and in the form of phospholipid), and carotenoids, which may exert beneficial effects on metabolic disorders in obesity-associated diseases. In the present study, the effect of SO on dysregulation of lipid metabolism was examined using C57BL/6N mice treated with high-fat (HF) diet. Mice were fed HF, HF with 2% SO, or HF with 5% SO diet for 8 weeks. Weight gain, blood glucose, serum and hepatic lipid contents, and hepatic fatty acid composition were measured...
June 13, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28621759/a-high-fructose-high-coconut-oil-diet-induces-dysregulating-expressions-of-hippocampal-leptin-and-stearoyl-coa-desaturase-and-spatial-memory-deficits-in-rats
#15
Ching-I Lin, Chu-Fu Shen, Tsui-Han Hsu, Shyh-Hsiang Lin
We investigated the effects of high-fructose-high-fat diets with different fat compositions on metabolic parameters, hippocampal-dependent cognitive function, and brain leptin (as well as stearoyl-CoA desaturase (SCD1) mRNA expressions). Thirty-two male Wistar rats were divided into 3 groups, a control group (n = 8), a high-fructose soybean oil group (37.5% of fat calories, n = 12), and a high-fructose coconut oil group (37.5% of fat calories, n = 12) for 20 weeks. By the end of the study, the coconut oil group exhibited significantly higher serum fasting glucose, fructosamine, insulin, leptin, and triglyceride levels compared to those of the control and soybean oil groups...
June 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28620248/relative-gene-expression-of-fatty-acid-synthesis-genes-at-60-days-postpartum-in-bovine-mammary-epithelial-cells-of-surti-and-jafarabadi-buffaloes
#16
Mamta Janmeda, Vishnu Kharadi, Gaurav Pandya, Balkrishna Brahmkshtri, Umed Ramani, Kuldeep Tyagi
AIM: Aim of the study was to study the relative gene expression of genes associated with fatty acid synthesis at 60 days postpartum (pp) in bovine mammary epithelial cells (MECs) of Surti and Jafarabadi buffaloes. MATERIALS AND METHODS: A total of 10 healthy Surti and Jafarabadi buffaloes of each breed were selected at random from Livestock Research Station, Navsari and Cattle Breeding Farm, Junagadh, Gujarat, respectively, for this study. Milk sample was collected from each selected buffalo at day 60 pp from these two breeds to study relative gene expression of major milk fat genes using non-invasive approach of obtaining primary bovine MECs (pBMEC) from milk samples...
May 2017: Veterinary World
https://www.readbyqxmd.com/read/28579896/the-cytoprotective-effects-of-%C3%AE-17-fatty-acid-desaturase-on-injured-huvecs-and-its-underlying-mechanism
#17
Xiulan Zhang, Shixin Xia, Qiqi Xu, Jiandong Huang
Endothelium toxicity has been involved in early endothelial dysfunction to show the pathogenesis of multiple cardiovascular disease that shows atherosclerosis and its complications. Saturated free fatty acids are the main inducing factors of endothelial cell apoptosis and inflammatory cytokines. In humans, stearoyl-CoA desaturase 1 (SCD-1) is a restriction step to saturation to unsaturated fatty acid desaturation, which plays a beneficial role protecting endothelial cells against lipotoxicity. Δ-17 fatty acid desaturase (FAD) is a newly identified FAD which shares 55% identity at the amino acid level with SCD-1...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28571972/discovery-of-novel-and-potent-stearoyl-coenzyme-a-desaturase-1-scd1-inhibitors-as-anticancer-agents
#18
Keisuke Imamura, Naoki Tomita, Youichi Kawakita, Yoshiteru Ito, Kouji Ono, Noriyuki Nii, Tohru Miyazaki, Kazuko Yonemori, Michiko Tawada, Hiroyuki Sumi, Yoshihiko Satoh, Yukiko Yamamoto, Ikuo Miyahisa, Masako Sasaki, Yoshinori Satomi, Megumi Hirayama, Ryuichi Nishigaki, Hironobu Maezaki
A lead compound A was identified previously as an stearoyl coenzyme A desaturase (SCD) inhibitor during research on potential treatments for obesity. This compound showed high SCD1 binding affinity, but a poor pharmacokinetic (PK) profile and limited chemical accessibility, making it suboptimal for use in anticancer research. To identify potent SCD1 inhibitors with more promising PK profiles, we newly designed a series of 'non-spiro' 4, 4-disubstituted piperidine derivatives based on molecular modeling studies...
May 11, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28571749/altered-expression-of-epidermal-lipid-bio-synthesis-enzymes-in-atopic-dermatitis-skin-is-accompanied-by-changes-in-stratum-corneum-lipid-composition
#19
M O Danso, W Boiten, V van Drongelen, K M Gmelig, G Gooris, A El Ghalbzouri, S Absalah, R Vreeken, S Kezic, J van Smeden, A P M Lavrijsen, J A Bouwstra
BACKGROUND: The barrier dysfunction in atopic dermatitis (AD) skin correlates with stratum corneum (SC) lipid abnormalities including reduction of global lipid content, shorter ceramide (CER) as well as free fatty acid (FFA) chain length and altered CER subclass levels. However, the underlying cause of these changes in lipid composition has not been fully investigated. AIM: We investigated whether the expression of CER and FFA biosynthesis enzymes are altered in AD skin compared with control skin and determine whether changes in enzyme expression can be related with changes in lipid composition...
May 18, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28559474/a-low-fat-diet-enriched-in-fish-oil-increased-lipogenesis-and-fetal-outcome-of-c57bl-6-mice
#20
Olatunji A Akerele, Sukhinder K Cheema
There is clear evidence that nutritional strategy employed during pregnancy has profound influence on the offspring health outcomes. However, the effect of the quality and the quantity of maternal fat intake on maternal metabolic profile during different stages of pregnancy and its impact on pregnancy sustainability is not known. Female C57BL/6 mice (7 weeks old) were fed diets varying in the quantity of fat (5% vs 11%) for two weeks prior to mating and throughout pregnancy. The 5% fat diet was enriched with longer chain omega (n)-3 polyunsaturated fatty acids (PUFA) from fish oil...
August 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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